| DrugBank ID |
Name |
Formula |
Weight |
DB00700
|
Eplerenone |
C24H30O6 |
414.4914 |
| Eplerenone Eplerenone Pathway SMP00135 Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone ... |
DB01344
|
Polystyrene sulfonate |
C8H7CaO3S |
223.2820 |
| ... renal impairment
Calcium Risk of alkalosis in renal impairment
Eplerenone Risk of alkalosis in renal impairment
Magnesium Risk of alkalosis in renal impairment
Potassium Risk of alkalosis in ... |
DB01345
|
Potassium |
K |
39.0983 |
| ... risk of hyperkaliemia
Enalapril Increased risk of hyperkaliemia
Eplerenone This association presents an increased risk of hyperkaliemia
Eprosartan Increased risk of hyperkaliemia
Forasartan ... |
DB00196
|
Fluconazole |
C13H12F2N6O |
306.2708 |
| ... Possible ergotism and severe ischemia with this combination
Eplerenone This CYP3A4 inhibitor increases the effect and toxicity of eplerenone
Ergotamine Possible ergotism and severe ischemia ... |
DB01149
|
Nefazodone |
C25H32ClN5O2 |
470.0070 |
| ... Eplerenone Nefazodone increases the effect and toxicity of eplerenone
Ergotamine Possible ergotism and severe ischemia with this combination
Erlotinib This CYP3A4 inhibitor increases levels ... |
DB00384
|
Triamterene |
C12H11N7 |
253.2626 |
| ... risk of hyperkaliemia
Enalapril Increased risk of hyperkaliemia
Eplerenone This association presents an increased risk of hyperkaliemia
Eprosartan Increased risk of hyperkaliemia
Forasartan ... |
DB00594
|
Amiloride |
C6H8ClN7O |
229.6270 |
| ... effect of quinidine
Enalapril Increased risk of hyperkaliemia
Eplerenone The association presents an ncreased risk of hyperkaliemia
Eprosartan Increased risk of hyperkaliemia
Forasartan ... |
DB00220
|
Nelfinavir |
C32H45N3O4S |
567.7820 |
| ... inhibitor increases the effect and toxicity of eletriptan
Eplerenone The protease inhibitor increases the effect and toxicity of eplerenone
Ergotamine Nelfinavir increases the effect and ... |
DB01211
|
Clarithromycin |
C38H69NO13 |
747.9534 |
| ... This macrolide increases the effect and toxicity of eletriptan
Eplerenone This macrolide increases the effect and toxicity of eplerenone
Ergotamine Risk of ergotism and severe ischemia with ... |
DB01356
|
Lithium |
Li |
6.9410 |
| ... The ACE inhibitor increases serum levels of lithium
Eplerenone Eplerenone increases serum levels of lithium
Eprosartan The ARB increases serum levels of lithium
Etoricoxib Etoricoxib increases ... |
DB01026
|
Ketoconazole |
C26H28Cl2N4O4 |
531.4310 |
| ... inhibitor increases the effect and toxicity of the triptan
Eplerenone The imidazole increases the effect and toxicity of eplerenone
Ergotamine Possible ergotism and sever ischemia with this ... |
DB00199
|
Erythromycin |
C37H67NO13 |
733.9268 |
| ... The macrolide increases the effect and toxicity of eletriptan
Eplerenone This CYP3A4 inhibitor increases the effect and toxicity of eplerenone
Ergonovine Possible ergotism and severe ischemia ... |
DB01167
|
Itraconazole |
C35H38Cl2N8O4 |
705.6330 |
| ... Eplerenone The imidazole increases the effect and toxicity of eplerenone
Ergotamine Possible ergotism and severe ischemia with this combination
Erlotinib This potent CYP3A4 inhibitor increases ... |
DB00976
|
Telithromycin |
C43H65N5O10 |
812.0037 |
| ... or monitor for changes in the therapeutic/adverse effects of Eplerenone if Telithromycin is initiated, discontinued or dose changed.
Ergoloid mesylate Telithromycin may reduce clearance of ... |
DB00519
|
Trandolapril |
C24H34N2O5 |
430.5372 |
| Monitor Trandolapril efficacy.
Eplerenone Increased risk of hyperkalemia. Monitor serum potassium levels.
Epoprostenol The prostacyclin analogue, Epoprostenol, may increase the hypotensive effect ... |
DB00374
|
Treprostinil |
C23H34O5 |
390.5131 |
| Monitor for increased bleeding during concomitant thearpy.
Eplerenone Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Eprosartan Additive hypotensive effect. |