| DrugBank ID |
Name |
Formula |
Weight |
DB00203
|
Sildenafil |
C22H30N6O4S |
474.5760 |
| Sildenafil Sildenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric ... |
DB00537
|
Ciprofloxacin |
C17H18FN3O3 |
331.3415 |
| ... bioavailability
Sildenafil The quinolone increases sildenafil levels
Sucralfate Formation of non-absorbable complexes
Theophylline The quinolone increases the effect of theophylline
Tizanidine ... |
DB00883
|
Isosorbide Dinitrate |
C6H8N2O8 |
236.1363 |
| ... antagonism of action
Methysergide Possible antagonism of action
Sildenafil Possible significant hypotension with this combination
Tadalafil Possible significant hypotension with this ... |
DB00727
|
Nitroglycerin |
C3H5N3O9 |
227.0865 |
| ... antagonism of action
Methysergide Possible antagonism of action
Sildenafil Possible significant hypotension with this combination
Tadalafil Possible significant hypotension with this ... |
DB01020
|
Isosorbide Mononitrate |
C6H9NO6 |
191.1388 |
| ... antagonism of action
Methysergide Possible antagonism of action
Sildenafil Possible significant hypotension with this combination
Tadalafil Possible significant hypotension with this ... |
DB00701
|
Amprenavir |
C25H35N3O6S |
505.6270 |
| ... The protease inhibitor increases the effect and toxicity of sildenafil
Simvastatin Amprenavir can possibly increase the statin toxicity
St. John's Wort St. John's Wort decreases the effect of ... |
DB01319
|
Fosamprenavir |
C25H36N3O9PS |
585.6070 |
| ... The protease inhibitor increases the effect and toxicity of sildenafil
Simvastatin Amprenavir can possibly increase the statin toxicity
St. John's Wort St. John's Wort decreases the effect of ... |
DB00220
|
Nelfinavir |
C32H45N3O4S |
567.7820 |
| ... toxicity
Rifampin Rifampin decreases the effect of nelfinavir
Sildenafil The protease inhibitor increases the effect and toxicity of sildenafil
Simvastatin Nelfinavir increases the effect and ... |
DB00224
|
Indinavir |
C36H47N5O4 |
613.7895 |
| ... symptoms
Saquinavir Possible antagonism of action
Sildenafil The protease inhibitor increases the effect and toxicity of sildenafil
St. John's Wort St. John's Wort decreases the effect of ... |
DB00501
|
Cimetidine |
C10H16N6S |
252.3390 |
| ... effect of quinidine
Rivastigmine Possible antagonism of action
Sildenafil Increases the effect and toxicity of sildenafil
Sufentanil Increases the effect of the narcotic
Tacrine Increases the ... |
DB01211
|
Clarithromycin |
C38H69NO13 |
747.9534 |
| ... combination
Sildenafil Increases the effect and toxicity of sildenafil
Simvastatin The macrolide possibly increases the statin toxicity
Sirolimus The macrolide increases sirolimus levels ... |
DB01072
|
Atazanavir |
C38H52N6O7 |
704.8555 |
| ... of atazanavir
Ritonavir Association with dose adjustment
Sildenafil Increases the effect and toxicity of sildenafil
Simvastatin Increased risk of myopathy/rhabdomyolysis
Sirolimus Increases ... |
DB01162
|
Terazosin |
C19H25N5O4 |
387.4329 |
| Sildenafil Increased risk of hypotension.
Sotalol Increased risk of hypotension. Initiate concomitant therapy cautiously.
Tadalafil Risk of significant hypotension with this association
Tamsulosin ... |
DB01026
|
Ketoconazole |
C26H28Cl2N4O4 |
531.4310 |
| ... Sildenafil The imidazole increases the effect and toxicity of sildenafil
Simvastatin Increased risk of myopathy/rhabdomyolysis
Sirolimus The imidazole increases the effect and toxicity of ... |
DB00199
|
Erythromycin |
C37H67NO13 |
733.9268 |
| ... Erythromycin increases the effect and toxicity of sibutramine
Sildenafil The macrolide increases the effect and toxicity of sildenafil
Simvastatin The macrolide possibly increases the statin ... |
DB01167
|
Itraconazole |
C35H38Cl2N8O4 |
705.6330 |
| ... Sildenafil The imidazole increases the effect and toxicity of sildenafil
Simvastatin Increased risk of myopathy/rhabdomyolysis
Simvastatin Increased risk of myopathy/rhabdomyolysis
Sirolimus ... |
DB00932
|
Tipranavir |
C31H33F3N2O5S |
602.6640 |
| ... administered with Ritonavir, may increase the concentration of Sildenafil. Alternate therapy should be considered.
Simvastatin Tipranavir, co-administered with Ritonavir, may increase the ... |
DB00976
|
Telithromycin |
C43H65N5O10 |
812.0037 |
| ... or monitor for changes in the therapeutic/adverse effects of Sildenafil if Telithromycin is initiated, discontinued or dose changed.
Simvastatin Telithromycin may possibly increase statin ... |