| Identification | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Name | Serum albumin iodonated | |||||||||
| Accession Number | DB00064 (BIOD00089, BTD00089) | |||||||||
| Type | biotech | |||||||||
| Groups | approved | |||||||||
| Description | A diagnostic radiopharmaceutical containing iodinated I 131 albumin for intravenous imaging. Following intravenous injection, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly (2 days). Indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times |
|||||||||
| Protein structure |
Display: 3D Structure |
|||||||||
| Protein chemical formula | C2936H4624N786O889S41 | |||||||||
| Protein average weight | 66472.2000 | |||||||||
| Sequences |
>DB00064 sequence DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAE NCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEV DVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLP KLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTK VHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPA DLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKC CAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVST PTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTES LVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKAT KEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL FASTA |
|||||||||
| Synonyms |
|
|||||||||
| Synonyms |
|
|||||||||
| Salts | Not Available | |||||||||
| Brand names |
|
|||||||||
| Brand mixtures | Not Available | |||||||||
| Categories |
|
|||||||||
| CAS number | 9048-49-1 | |||||||||
| Taxonomy | ||||||||||
| Kingdom | Not Available | |||||||||
| Classes | Not Available | |||||||||
| Substructures | Not Available | |||||||||
| Pharmacology | ||||||||||
| Indication | For determination of total blood and plasma volumes | |||||||||
| Pharmacodynamics | Regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation. | |||||||||
| Mechanism of action | Serum albumin acts as a high molecular weight, very soluble osmolyte | |||||||||
| Absorption | Not Available | |||||||||
| Volume of distribution | Not Available | |||||||||
| Protein binding | Not Available | |||||||||
| Metabolism | Not Available | |||||||||
| Route of elimination | Not Available | |||||||||
| Half life | Not Available | |||||||||
| Clearance | Not Available | |||||||||
| Toxicity | Not Available | |||||||||
| Affected organisms |
|
|||||||||
| Pathways | Not Available | |||||||||
| Pharmacoeconomics | ||||||||||
| Manufacturers |
|
|||||||||
| Packagers | Not Available | |||||||||
| Dosage forms | Not Available | |||||||||
| Prices | Not Available | |||||||||
| Patents | Not Available | |||||||||
| Properties | ||||||||||
| State | liquid | |||||||||
| Melting point | 62 oC (Flora, K. et al., Biophys J. 75:1084-1096 (1998)) | |||||||||
| Experimental Properties |
|
|||||||||
| References | ||||||||||
| Synthesis Reference | Not Available | |||||||||
| General Reference | Not Available | |||||||||
| External Links |
|
|||||||||
| ATC Codes | Not Available | |||||||||
| AHFS Codes | Not Available | |||||||||
| PDB Entries | ||||||||||
| FDA label | Not Available | |||||||||
| MSDS | Not Available | |||||||||
| Interactions | ||||||||||
| Drug Interactions | Searched, but no interactions found. | |||||||||
| Food Interactions | Not Available | |||||||||
| Targets |
|---|
|
Pharmacological action: unknown
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues Organism class: humanUniProt ID: P02649  Gene: APOE Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References:
Pharmacological action: unknown
Major acute phase reactant. Apolipoprotein of the HDL complex Organism class: humanUniProt ID: P02735 Gene: SAA1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References:
3. AMBP protein Pharmacological action: unknownInter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, plasmin, and lysosomal granulocytic elastase Organism class: humanUniProt ID: P02760 Gene: AMBP Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: |
| Comments |
|---|
Drug created on June 13, 2005 07:24 / Updated on September 03, 2011 17:04