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Accession NumberDB00094  (BIOD00104, BTD00104)

Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Urofollitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Urofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF).

Protein structureDb00094
Protein chemical formulaC42H65N11O12S2
Protein average weight980.162 Da
>Alpha chain
>Beta chain
Download FASTA Format
Follicle Stimulating Hormone
Follicle-stimulating hormone beta subunit
Follitropin beta chain precursor
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BravellekitsubcutaneousFerring Pharmaceuticals Inc.2002-05-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Bravellepowder for solution75 unitintramuscular; subcutaneousFerring Inc2005-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Metrodin 75 I.U.powder for solution75 unitintramuscularIndustria Farmaceutica Serono Spa1988-12-311999-08-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription ProductsNot Available
Over the Counter ProductsNot Available
International Brands
FertinexSerono S.A.
MetrodinSerum Inst.
Brand mixtures
Fertinorm Hp 150 - Pws Diluent Im ScEmd Serono A Division Of Emd Inc Canada
Fertinorm Hp 75 - Pws Diluent Im ScEmd Serono A Division Of Emd Inc Canada
Humegon Inj 75 I.U.Organon Canada Ltd Ltee
Pergonal 75 I.U.Emd Serono A Division Of Emd Inc Canada
SaltsNot Available
CAS number146479-72-3
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
IndicationFor treatment of female infertility
PharmacodynamicsUsed for the treatment of female infertility, urofollitropin or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of urofollitropin is the primary hormone responsible for follicular recruitment and development.
Mechanism of actionFSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
Volume of distribution

Time to peak in plasma:
IM: 17 hours (single dose), 11 hours (multiple doses)
SubQ: 21 hours (single dose), 10 hours (multiple doses)

Protein bindingNot Available
MetabolismNot Available
Route of eliminationVia liver and kidneys
Half lifeCirculation half life of 3-4 hours, elimination half life of 35-40 hours
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
  • Serono laboratories inc
  • Ferring pharmaceuticals inc
Dosage forms
Powder for solutionintramuscular; subcutaneous75 unit
Kit; liquid; powder for solutionintramuscular; subcutaneous
Liquid; powder for solutionintramuscular; subcutaneous
Liquid; powder for solutionintramuscular
Powder for solutionintramuscular75 unit
Powder for solutionintramuscular
Unit descriptionCostUnit
Fertinex 75 unit Solution103.85USD vial
Bravelle 75 unit vial93.85USD vial
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
CountryPatent NumberApprovedExpires (estimated)
United States57670671995-06-162015-06-16
Experimental Properties
melting point55 °CForastieri, H., Ingham, K.C. J. Biol. Chem. 257:7976-7981 (1982)
hydrophobicity-0.330Not Available
isoelectric point7.50Not Available
Synthesis ReferenceNot Available
General References
  1. Goa KL, Wagstaff AJ: Follitropin alpha in infertility: a review. BioDrugs. 1998 Mar;9(3):235-60. Pubmed
    #Lexicomp. Urofollitropin. N.p., 2014. Web. 11 Nov. 2014.
External Links
ATC CodesG03GA04
AHFS Codes
  • 68:18.00
PDB Entries
FDA labelDownload (174 KB)
MSDSNot Available
Drug InteractionsNo interactions found.
Food InteractionsNot Available


1. Follicle-stimulating hormone receptor

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: agonist


Name UniProt ID Details
Follicle-stimulating hormone receptor P23945 Details


  1. Layman LC: Mutations in the follicle-stimulating hormone-beta (FSH beta) and FSH receptor genes in mice and humans. Semin Reprod Med. 2000;18(1):5-10. Pubmed
  2. Leng N, Dattatreyamurty B, Reichert LE Jr: Identification of amino acid residues 300-315 of the rat FSH receptor as a hormone binding domain: evidence for its interaction with specific regions of FSH beta-subunit. Biochem Biophys Res Commun. 1995 May 16;210(2):392-9. Pubmed
  3. Santa Coloma TA, Dattatreyamurty B, Reichert LE Jr: A synthetic peptide corresponding to human FSH beta-subunit 33-53 binds to FSH receptor, stimulates basal estradiol biosynthesis, and is a partial antagonist of FSH. Biochemistry. 1990 Feb 6;29(5):1194-200. Pubmed
  4. Dattatreyamurty B, Reichert LE Jr: Identification of regions of the follitropin (FSH) beta-subunit that interact with the N-terminus region (residues 9-30) of the FSH receptor. Mol Cell Endocrinol. 1993 May;93(1):39-46. Pubmed
  5. Lindau-Shepard B, Roth KE, Dias JA: Identification of amino acids in the C-terminal region of human follicle-stimulating hormone (FSH) beta-subunit involved in binding to human FSH receptor. Endocrinology. 1994 Sep;135(3):1235-40. Pubmed
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on January 14, 2016 10:24