Showing BioInteractions for Tetrahydrofolic acid (DB00116)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a C-1-tetrahydrofolate synthase, cytoplasmic cofactor | ||
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial cofactor | ||
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Aminomethyltransferase, mitochondrial cofactor | ||
| 1 | Aminomethyltransferase, mitochondrial substrates | Glycine |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Cytosolic 10-formyltetrahydrofolate dehydrogenase cofactor | ||
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Methionine synthase cofactor | ||
| 1 | Methionine synthase cofactors | Cyanocobalamin, Hydroxocobalamin, Levomefolic acid, Mecobalamin |
| 2 | Methionine synthase substrates | Levomefolic acid |
| 3 | Methionine synthase antagonists | Thimerosal |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Formimidoyltransferase-cyclodeaminase cofactor | ||
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Bifunctional purine biosynthesis protein PURH cofactor | ||
| 1 | Bifunctional purine biosynthesis protein PURH inhibitors | Methotrexate, Pemetrexed |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Serine hydroxymethyltransferase, cytosolic cofactor | ||
| 1 | Serine hydroxymethyltransferase, cytosolic inhibitors | Mimosine |
| 2 | Serine hydroxymethyltransferase, cytosolic cofactors | Pyridoxal phosphate |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Serine hydroxymethyltransferase, mitochondrial cofactor | ||
| 1 | Serine hydroxymethyltransferase, mitochondrial cofactors | Pyridoxal phosphate |
| 2 | Serine hydroxymethyltransferase, mitochondrial ligands | Artenimol |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Methylenetetrahydrofolate reductase cofactor | ||
| 1 | Methylenetetrahydrofolate reductase cofactors | Cyanocobalamin, Riboflavin |
| 2 | Methylenetetrahydrofolate reductase inhibitors | Methionine |
| 3 | Methylenetetrahydrofolate reductase substrates | Benazepril, Fluorouracil, Folic acid, Menadione, Methotrexate |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Serine hydroxymethyltransferase cofactor | ||
| 1 | Serine hydroxymethyltransferase cofactors | Pyridoxal phosphate |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Tetrahydrofolic acid is a Methionyl-tRNA formyltransferase, mitochondrial cofactor | ||