Showing BioInteractions for Folic acid (DB00158)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting Group | Interacting Drugs | |
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Folic acid is a Folate receptor gamma binder |
Interacting Group | Interacting Drugs | |
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Folic acid is a Folate receptor beta binder | ||
1 | Folate receptor beta substrates | Methotrexate |
Interacting Group | Interacting Drugs | |
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Folic acid is a Methylenetetrahydrofolate reductase substrate | ||
1 | Methylenetetrahydrofolate reductase cofactors | Cyanocobalamin, Riboflavin, Tetrahydrofolic acid |
2 | Methylenetetrahydrofolate reductase inhibitors | Methionine |
3 | Methylenetetrahydrofolate reductase substrates | Benazepril, Fluorouracil, Menadione, Methotrexate |
Interacting Group | Interacting Drugs | |
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Folic acid is a Gamma-glutamyl hydrolase substrate | ||
1 | Gamma-glutamyl hydrolase substrates | Methotrexate |
Interacting Group | Interacting Drugs | |
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Folic acid is a Dihydrofolate reductase substrate | ||
1 | Dihydrofolate reductase inhibitors | Aminopterin, Lamotrigine, Methotrexate, Pemetrexed, Pralatrexate, Proguanil, Pyrimethamine, Trimetrexate |
2 | Dihydrofolate reductase substrates | Methotrexate, Trimetrexate |
Interacting Group | Interacting Drugs | |
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Folic acid is a Multidrug resistance-associated protein 4 inhibitor | ||
1 | Multidrug resistance-associated protein 4 substrates | Adefovir dipivoxil, Alprostadil, Atorvastatin, Cefazolin, Cyclic adenosine monophosphate, Dinoprostone, Fluciclovine (18F), Fluorouracil, Gadoxetic acid, Glutathione, Hydrochlorothiazide, Lamivudine, Mercaptopurine, Methotrexate, Nateglinide, Oseltamivir, Prasterone, Raloxifene, Rosuvastatin, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Zidovudine |
2 | Multidrug resistance-associated protein 4 inhibitors | Celecoxib, Cholic Acid, Conjugated estrogens, Cyclic adenosine monophosphate, Diclofenac, Dipyridamole, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Methotrexate, Probenecid, Promethazine, Remdesivir, Rofecoxib, Rucaparib, Sildenafil, Sorafenib, Sulfinpyrazone, Sunitinib, Taurocholic acid, Tioguanine, Ursodeoxycholic acid, Verapamil |
3 | Multidrug resistance-associated protein 4 binders | Meloxicam |
Interacting Group | Interacting Drugs | |
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Folic acid is a Canalicular multispecific organic anion transporter 2 substrate | ||
1 | Canalicular multispecific organic anion transporter 2 inducers | Cisplatin, Metyrapone, Nifedipine, Omeprazole, Phenobarbital, Rifampicin |
2 | Canalicular multispecific organic anion transporter 2 inhibitors | Bempedoic acid, Cholic Acid, Conjugated estrogens, Doxorubicin, Etoposide, Glyburide, Indomethacin, Methotrexate, Probenecid, Promethazine, Sulfinpyrazone, Taurocholic acid, Verapamil, Vincristine |
3 | Canalicular multispecific organic anion transporter 2 substrates | Belantamab mafodotin, Etoposide, Ezetimibe, Fexofenadine, Fluorouracil, Gadoxetic acid, Glutathione, Lamivudine, Methotrexate, Raloxifene, Taurocholic acid |
Interacting Group | Interacting Drugs | |
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Folic acid is a ATP-binding cassette sub-family C member 11 substrate | ||
1 | ATP-binding cassette sub-family C member 11 inhibitors | Cyclic adenosine monophosphate, Indomethacin, Probenecid, Taurocholic acid |
2 | ATP-binding cassette sub-family C member 11 substrates | Conjugated estrogens, Cyclic adenosine monophosphate, Methotrexate |
Interacting Group | Interacting Drugs | |
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Folic acid is a Proton-coupled folate transporter substrate | ||
1 | Proton-coupled folate transporter substrates | Levomefolic acid, Methotrexate |
2 | Proton-coupled folate transporter inhibitors | Methotrexate, Sulfasalazine |
Interacting Group | Interacting Drugs | |
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Folic acid is a Mitochondrial folate transporter/carrier substrate |