Showing BioInteractions for Icosapent (DB00159)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 9

	Interacting Group	Interacting Drugs
	Icosapent is a Prostaglandin G/H synthase 2 inhibitor
1	Prostaglandin G/H synthase 2 inhibitors	Aceclofenac, Acetaminophen, Acetylsalicylic acid, Aminosalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Cannabidiol, Capsaicin, Carprofen, Celecoxib, Chlorphenesin, Choline magnesium trisalicylate, Cimicoxib, Cisplatin, Clodronic acid, Dexibuprofen, Dexketoprofen, Diclofenac, Diflunisal, Drospirenone, Droxicam, Etodolac, Etoricoxib, Fenoprofen, Fish oil, Flurbiprofen, Ginseng, Ibuprofen, Indomethacin, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Medical Cannabis, Mefenamic acid, Meloxicam, Mesalazine, Morniflumate, Nabiximols, Nabumetone, Naproxen, Nepafenac, Niflumic acid, Nimesulide, Oxaprozin, Parecoxib, Phenylbutazone, Piroxicam, Pomalidomide, Resveratrol, Rofecoxib, Salicylic acid, Salsalate, Seliciclib, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Triamcinolone, Trolamine salicylate, Valdecoxib
2	Prostaglandin G/H synthase 2 negative modulators	Lenalidomide
3	Prostaglandin G/H synthase 2 antagonists	Acemetacin, Alclofenac, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Thalidomide, Tolfenamic acid
4	Prostaglandin G/H synthase 2 substrates	Dapsone, Etoposide, Omega-3 fatty acids, Omega-6 fatty acids, Thalidomide
5	Prostaglandin G/H synthase 2 inducers	Aldesleukin, Bryostatin 1, Bumetanide, Desmopressin, Drospirenone, Nonoxynol-9, Prasterone sulfate, Risedronic acid, Sapropterin, Sar9, Met (O2)11-Substance P, Semaxanib, Tafluprost

	Interacting Group	Interacting Drugs
	Icosapent is a Prostaglandin G/H synthase 1 inhibitor
1	Prostaglandin G/H synthase 1 inhibitors	Aceclofenac, Acetaminophen, Acetylsalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Cannabidiol, Carprofen, Choline magnesium trisalicylate, Dexibuprofen, Dexketoprofen, Diclofenac, Diethylcarbamazine, Diflunisal, Dihomo-gamma-linolenic acid, Droxicam, Etodolac, Fenoprofen, Flurbiprofen, Hyperforin, Ibuprofen, Indomethacin, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Medical Cannabis, Mefenamic acid, Meloxicam, Mesalazine, Nabiximols, Nabumetone, Naproxen, Nepafenac, Nitroaspirin, Oxaprozin, Phenylbutazone, Piroxicam, Resveratrol, Salicylic acid, Salsalate, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Trolamine salicylate
2	Prostaglandin G/H synthase 1 inducers	Desmopressin, Minoxidil
3	Prostaglandin G/H synthase 1 substrates	Candesartan, Candesartan cilexetil, Chlorpropamide, Dapsone, Diazepam, Diphenhydramine, Dronabinol, Eletriptan, Etoposide, Hexobarbital, Ifosfamide, Imatinib, Irbesartan, Ketamine, Ketobemidone, Montelukast, Nateglinide, Rofecoxib, Rosiglitazone, Seratrodast, Terbinafine, Thalidomide, Trabectedin, Valproic acid, Voriconazole, Zafirlukast, Zaltoprofen, Zileuton, Zopiclone
4	Prostaglandin G/H synthase 1 antagonists	Acemetacin, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Tolfenamic acid, Triflusal

	Interacting Group	Interacting Drugs
	Icosapent is a Free fatty acid receptor 1 agonist

	Interacting Group	Interacting Drugs
	Icosapent is a Fatty acid desaturase 1 agonist
1	Fatty acid desaturase 1 ligands	alpha-Linolenic acid, Evening primrose oil
2	Fatty acid desaturase 1 substrates	Omega-6 fatty acids, Vayarin

	Interacting Group	Interacting Drugs
	Icosapent is a Long-chain-fatty-acid--CoA ligase 4 inducer
1	Long-chain-fatty-acid--CoA ligase 4 inhibitors	Rosiglitazone, Troglitazone

	Interacting Group	Interacting Drugs
	Icosapent is a Sodium/calcium exchanger 1 inhibitor
1	Sodium/calcium exchanger 1 inhibitors	Dronedarone
2	Sodium/calcium exchanger 1 substrates	Calcium citrate, Calcium Phosphate
3	Sodium/calcium exchanger 1 inducers	Strontium chloride Sr-89

	Interacting Group	Interacting Drugs
	Icosapent is a Peroxisome proliferator-activated receptor gamma agonist
1	Peroxisome proliferator-activated receptor gamma agonists	Aleglitazar, Amiodarone, Balsalazide, Bezafibrate, Darglitazone, Flufenamic acid, Glipizide, Isoflavone, Mesalazine, Mitiglinide, Nateglinide, Pioglitazone, Repaglinide, Rosiglitazone, Sulfasalazine, Troglitazone
2	Peroxisome proliferator-activated receptor gamma partial agonists	AMG-131, Telmisartan
3	Peroxisome proliferator-activated receptor gamma activators	Cannabidiol, Dexibuprofen, Ibuprofen, Indomethacin, Lobeglitazone
4	Peroxisome proliferator-activated receptor gamma ligands	Capric acid, Doconexent, Oleic Acid, Omega-3 fatty acids
5	Peroxisome proliferator-activated receptor gamma modulators	Clofazimine

	Interacting Group	Interacting Drugs
	Icosapent is a Peroxisome proliferator-activated receptor delta agonist
1	Peroxisome proliferator-activated receptor delta agonists	Bezafibrate, Cardarine, Glycerin, Treprostinil
2	Peroxisome proliferator-activated receptor delta negative modulators	Sulindac

	Interacting Group	Interacting Drugs
	Icosapent is a Transient receptor potential cation channel subfamily V member 1 inducer
1	Transient receptor potential cation channel subfamily V member 1 inhibitors	alpha-Linolenic acid
2	Transient receptor potential cation channel subfamily V member 1 inducers	Aspartame
3	Transient receptor potential cation channel subfamily V member 1 agonists	(S)-camphor, Camphor, Cannabidivarin, Capsaicin, Capsicum oleoresin, Nonivamide, Tramadol, Zucapsaicin
4	Transient receptor potential cation channel subfamily V member 1 activators	(S)-camphor, Acetaminophen, Camphor, Cannabidiol, Capsicum oleoresin, Zucapsaicin
5	Transient receptor potential cation channel subfamily V member 1 antagonists	Propacetamol