Showing BioInteractions for Valine (DB00161)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Valine is a Valine--tRNA ligase substrate | ||
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Valine is a Propionyl-CoA carboxylase beta chain, mitochondrial substrate | ||
| 1 | Propionyl-CoA carboxylase beta chain, mitochondrial cofactors | Biotin |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Valine is a Branched-chain-amino-acid aminotransferase, cytosolic substrate | ||
| 1 | Branched-chain-amino-acid aminotransferase, cytosolic cofactors | Pyridoxal phosphate |
| 2 | Branched-chain-amino-acid aminotransferase, cytosolic inhibitors | Gabapentin |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Valine is a Monocarboxylate transporter 10 inhibitor | ||
| 1 | Monocarboxylate transporter 10 inhibitors | Alanine, Arginine, Asparagine, Aspartic acid, Cysteine, Cystine, D-Alanine, D-Leucine, D-Phenylalanine, D-Serine, D-Tryptophan, D-Tyrosine, Droxidopa, Glutamic acid, Glycine, Histidine, Isoleucine, L-Glutamine, Lactic acid, Leucine, Levodopa, Liothyronine, Liotrix, Lysine, Methionine, Phenylalanine, Proline, Pyruvic acid, Serine, Threonine, Tryptophan, Tyrosine |
| 2 | Monocarboxylate transporter 10 substrates | 2-aminoisobutyric acid, beta-Alanine, D-Phenylalanine, Glutamic acid, Glycine, Histidine, Lactic acid, Lysine, Pyruvic acid |