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Identification
NamePyridoxine
Accession NumberDB00165  (NUTR00002, APRD00204)
TypeSmall Molecule
GroupsApproved, Nutraceutical, Vet Approved
Description

Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]

Structure
Thumb
Synonyms
2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
3-Hydroxy-4,5-dimethylol-alpha-picoline
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
Pyridoxine
Pyridoxol
Vitamin B6
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
B6 400mg Ctr Tabtablet (extended-release)400 mgBioenergy Inc.1979-12-311998-06-03Canada
Cataplex F Tab 2mgtablet2 mgoralStandard Process Inc.Not applicableNot applicableCanada
Pyridoxine HCl Inj 100mg/mlliquid100 mgintramuscular; intravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Pyridoxine HCl Tab 100mgtablet100 mgEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada
Pyridoxine Hydrochloride Injection 100mg/mlsolution100 mgintramuscular; intravenousHospira Healthcare Corporation1981-12-31Not applicableCanada
Pyridoxine Hydrochloride Injection USP 100 mg/mlsolution100 mgintramuscular; intravenousAlveda Pharmaceuticals IncNot applicableNot applicableCanada
Pyridoxine Hydrochloride Injection, USPsolution100 mgintramuscular; intravenousMylan Pharmaceuticals Ulc2002-06-01Not applicableCanada
Vit B6 Ctr Srt 100mgtablet (extended-release)100 mgBioenergy Inc.1981-12-311998-06-03Canada
Vitamin B6 250 Mg Capsulescapsule250 mgoralSelf Health Resource CentreNot applicableNot applicableCanada
Vitamin B6 Tablettablet100 mgoralLeiner Health Products Inc.Not applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Pyridoxine Hydrochlorideinjection, solution100 mg/mLintramuscular; intravenousFresenius Kabi USA, LLC1972-08-14Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
B-6 500mg Continuous Releasedtablet (extended-release)500 mgoralGahler Enterprises Ltd.1981-12-312007-08-07Canada
B-6 Caps 250mgcapsule250 mgoralTwin Laboratories Inc.1995-12-311999-11-10Canada
B6 100mg Pyridoxine HCltablet100 mgoralWn Pharmaceuticals Ltd.2001-10-012009-09-28Canada
B6 25 Tab 25mgtablet25 mgoralLe Naturiste J.M.B. Inc.1990-12-311997-07-23Canada
B6 250 Caplet 250mgtablet250 mgoralHealth Wise Nutrition Inc.1996-11-131997-08-07Canada
B6 Cap 100mgcapsule100 mgoralGahler Enterprises Ltd.1989-12-312008-07-17Canada
B6 Pyridoxine HCl Tab 50mgtablet50 mgoralGahler Enterprises Ltd.1984-12-312008-07-17Canada
B6 Tab 100mgtablet100 mgoralAlbi Naturals1979-12-312008-07-17Canada
B6 Tablets 100mgtablet100 mgoralGahler Enterprises Ltd.1988-12-312008-07-17Canada
Formula A.L.- Tab 17mgtablet17 mgoralAbundance Marketing Ltd.1996-11-051999-08-06Canada
Formule No 202 Profil Tab 8.45gmtablet8.45 mgoralPharmalab Inc.1987-12-312001-07-30Canada
Hi Potency Klb6 Tab 17mgtablet17 mgoralSwiss Herbal Remedies Ltd.1981-12-312003-09-10Canada
Klb 6 Tabtablet6 mgoralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Klb 6 Tab 8.33mgtablet8.33 mgoralPure Life International Prods Inc.1992-12-312001-08-07Canada
Klb6 Tablets 17mgtablet17 mgoralGahler Enterprises Ltd.1988-12-312002-07-17Canada
Lgb-dtx Tab 10mgtablet10 mgoralMetagenics, Inc.1989-12-312002-10-07Canada
Linum B6 Tab 2mgtablet2 mgoralStandard Process Inc.Not applicableNot applicableCanada
Nutrol-B6 Tab 100mgtablet100 mgoralRolmex International Inc.1989-12-311997-08-08Canada
Pyridoxen Tab 50mgtablet50 mgoralSantÉ Naturelle (Ag) LtÉe1987-12-311999-08-18Canada
Pyridoxinetablet250 mgoralSeroyal International Inc.1988-12-312009-07-06Canada
Pyridoxine HCl Tab 25mgtablet25 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Pyridoxine HCl Tab 25mgtablet25 mgoralSwiss Herbal Remedies Ltd.1971-12-312003-09-10Canada
Pyridoxine HCl Tab 50mgtablet50 mgoralSwiss Herbal Remedies Ltd.1989-12-312004-09-03Canada
Pyridoxine-S Tab 50mgtablet50 mgoralNutri West Products Ltd.1993-12-311997-08-05Canada
Super Klb6 Tab 17mgtablet17 mgoralAlbi Imports Ltd.1981-12-311996-09-09Canada
Super Klb6 Tab 17mgtablet17 mgoralCountry Health Laboratories Ltd.1981-12-312001-07-27Canada
Vit B6 Pyridoxine HCl Tab 50mg USPtablet50 mgoralPure Life International Prods Inc.1992-12-312001-08-07Canada
Vit B6 Tab 250mgtablet250 mgoralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Vita-doxine Cap 250mgcapsule250 mgoralLes Laboratoires Vachon Inc.1990-12-312001-08-07Canada
Vitamin B-6 50 Mg Tablettablet50 mgoralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Vitamin B-6 100mgcapsule100 mgoralNutraceutical Corporation2003-10-012007-08-02Canada
Vitamin B-6 100mg Tabtablet100 mgoralPharmavite Llc1993-12-312006-07-05Canada
Vitamin B-6 17mg Tabtablet17 mgoralPharmavite Llc1993-12-311998-09-08Canada
Vitamin B-6 200mgcapsule200 mgoralNutraceutical Corporation2003-09-022006-08-02Canada
Vitamin B-6 Tab 200mgtablet200 mgoralNutri West Products Ltd.1988-12-312002-06-14Canada
Vitamin B6tablet250 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1983-12-312002-07-31Canada
Vitamin B6 50mg Tabtablet50 mgoralNutricorp International1993-12-312009-08-05Canada
Vitamin B6 100 mgcapsule100 mgoralHolista Health (Canada) Inc.2002-11-132008-07-17Canada
Vitamin B6 100 Mg USPtablet100 mgoralAccurex Health Care Manufacturing Inc.2002-06-262009-07-31Canada
Vitamin B6 100mgtablet100 mgoralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin B6 100mg Caplettablet100 mgoralHealth Wise Nutrition Inc.1994-12-312002-07-18Canada
Vitamin B6 100mg Tabtablet100 mgoralJamieson Laboratories Ltd1994-12-311996-09-10Canada
Vitamin B6 200mgtablet200 mgoralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin B6 50mgtablet50 mgoralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin B6 Cap 250mgcapsule250 mgoralQuest Vitamins A Div Of Purity Life Health Products1980-12-312002-07-29Canada
Vitamin B6 Capsules 100mgcapsule100 mgoralQuest Vitamins A Div Of Purity Life Health Products1989-12-312001-07-06Canada
Vitamin B6 Capsules 3.5mgcapsule3.5 mgoralVita Health Products Inc1990-12-311997-08-18Canada
Vitamin B6 Tab 100mgtablet100 mgoralWampole Brands1979-12-312004-06-29Canada
Vitamin B6 Tab 100mgtablet100 mgoralShoppers Drug Mart Inc.1980-12-311997-08-15Canada
Vitamin B6 Tab 100mgtablet100 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1980-12-312002-07-31Canada
Vitamin B6 Tab 100mgtablet100 mgoralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Vitamin B6 Tab 100mgtablet100 mgoralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
Vitamin B6 Tab 100mg USPtablet100 mgoralAlive Vitamins1987-12-311997-08-11Canada
Vitamin B6 Tab 250mgtablet250 mgoralNutri Dyn Products Ltd.1976-12-311997-08-22Canada
Vitamin B6 Tab 250mgtablet250 mgoralVita Health Products Inc1985-12-312005-07-20Canada
Vitamin B6 Tab 25mgtablet25 mgoralVita Health Products Inc1975-12-312002-07-31Canada
Vitamin B6 Tab 25mgtablet25 mgoralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1978-12-312002-07-29Canada
Vitamin B6 Tab 25mgtablet25 mgoralAvacare, Division Of Jeunique International Inc.1985-12-311996-09-09Canada
Vitamin B6 Tab 25mgtablet25 mgoralAlbi Naturals1979-12-312008-07-17Canada
Vitamin B6 Tab 50mgtablet50 mgoralQuest Vitamins A Div Of Purity Life Health Products1977-12-312001-07-06Canada
Vitamin B6 Tab 50mgtablet50 mgoralVita Health Products Inc1977-12-312008-08-05Canada
Vitamin B6 Tab 50mgtablet50 mgoralNutristar Health Products (1987) Inc.1980-12-311996-09-09Canada
Vitamin B6 Tablets 250mgtablet250 mgoralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Vitamin B6 Tablets-250mgtablet250 mgoralDa Vinci Laboratories, Division Of Foodscience Corporation2002-06-172007-07-18Canada
Vitamine B6 100 Mg - Tablettablet100 mgoralNobel Pharm Enr.1995-12-312001-10-15Canada
Vitamine B6 100mgtablet100 mgoralGamme Nature1990-12-312004-07-26Canada
Vitamine B6 25mg Comprimetablet25 mgoralBio Vita1988-03-231997-08-07Canada
Vitamine B6 Tab 100mg USPtablet100 mgoralLaboratoire Lalco Inc.1986-12-312004-07-26Canada
Vitamine B6 Tab 250mgtablet250 mgoralLes Produits Gerbex Inc.1985-12-311997-08-11Canada
Vitamine B6 Tab 25mg USP Chewabletablet25 mgoralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Unapproved/Other Products Not Available
International Brands
NameCompany
BecilanNot Available
BeesixNot Available
BenadonNot Available
BonasanitNot Available
Hexa-BetalinNot Available
HexobionNot Available
NestrexNot Available
Brand mixtures
NameLabellerIngredients
A.R.T.H. Away FormulaAbundance Marketing Ltd.
Acetabolan III Vitamin and Mineral SupplementIovate Health Sciences International Inc.
Acetabolan-II Vitamin and Mineral SupplementIovate Health Sciences International Inc.
Active FeGm Pharmaceuticals, Inc.
AcvAbundance Marketing Ltd.
Adrenogist TabPure Life International Prods Inc.
Advanced 2000 CapsulesBody Gold, A Division Of Pep Products, Inc.
AlertonicOdan Laboratories Ltd
Allbee With C 550 CapWhitehall Robins Inc.
Allbee With Vitamin C CapWhitehall Robins Inc.
Alsimine W Vitamins A DAlsi Cie Ltee
Am CapsNew Vision Nutritionals Company
American Eagle Energizer Plus Vitamin Supplement DrinkP.S.W.C. Co., Inc.
American Plus Energy & Vitamin DrinkP.S.W.C. Co., Inc.
Animi-3PBM Pharmaceuticals, Inc
Animi-3 With Vitamin DPBM Pharmaceuticals, Inc
AntlervironClassical Remedia Ltd
Aqua-S SupplementGarden State Nutritionals
Av-vite FbAv Kare, Inc.
B 50 CapsulesRheingold Food International Ltd.
B 6 PlusAnabolic Laboratories Inc.
B C Antistress CapLes Laboratoires Bio SantÉ Inc.
B Complex 25mg Vitamin SupplementGarden State Nutritionals
B Complex 50 Vitamin CapBioforce Canada Inc.
B Complex 50+ CapletHealth Wise Nutrition Inc.
B Complex 500 TabNobel Pharm Enr.
B Complex Plus C 300mg TabNutricorp International
B Complex TabletsGolden Neo Life Diamite International, Limited
B Complex W C and B12 InjE L Stickley And Co Ltd.
B Complex W C Forte CapEverest Pharmaceuticals Ltd.
B Complex W Vit C W Non-med Yeast&liver TabPharmavite Llc
B Complex W Vitamin C Fortis CapShoppers Drug Mart Inc.
B Complex With C 300mgVita Health Products Inc
B Complex With C 300mg TabPharmavite Llc
B Complex With C 550mgVita Health Products Inc
B Compound 50mg TabGahler Enterprises Ltd.
B Plus C 300 mgVita Health Products Inc
B Plus C 300mg Timed ReleaseVita Health Products Inc
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
B Totum 500Desbergers LtÉe, Division Of Technilab Inc.
B VirolRolmex International Inc.
B With C 500 CapPharmetics (2011) Inc
B-100 CapsNow Foods
B-100 Complex TabletsViva Pharmaceutical Inc.
B-100 Hi Potency B Vitamins TabNatrol, Inc.
B-100 Vitamin SupplementGarden State Nutritionals
B-50 ComplexVita Health Products Inc
B-50 Complex TabVita Health Products Inc
B-50 Hi Potency B Vitamins TabNatrol, Inc.
B-complexEnrich International
B-complex 100Great Earth Companies, Inc.
B-complex 50Great Earth Companies, Inc.
B-complex TabNature's Sunshine Products Of Canada Ltd.
B-complex TabletsShaklee Canada Inc
B-complex With Vitamin C, Biotin, Folic AcidWn Pharmaceuticals Ltd.
B-complex-50 TabJr Carlson Labs Inc
B-nexaUpsher Smith Laboratories, Inc.
B-plexWn Pharmaceuticals Ltd.
B-plex 100Merit Pharmaceutical
B-plus - TabChampion's Choice Advanced Nutrition Inc.
B50 B Complex TabNutristar Health Products (1987) Inc.
B50 ComplexPreferred Nutrition Inc.
B6 Plus TabVita Health Products Inc
B6-niacinamide TabStandard Process Inc.
B6, B12 & Folic AcidNatural Factors Nutritional Products Ltd.
B6, B12 & Folic Acid Multi-vitamin TabletsWampole Brands
BacminMarnel Pharmaceuticals, Inc.
BaisixProdemdis Enr.
Balanced B 125 SrtAnabolic Laboratories Inc.
Balanced B-100 B-complex Vitamins TabPharmavite Llc
Balanced B-100 Timed ReleasePharmavite Llc
Balanced B-50 B-complex Vitamins TabPharmavite Llc
Balanced B-50 B-complex Vitamins, Timed RelePharmavite Llc
Balanced B-50 ComplexLeiner Health Products Inc.
Balanced B-complex Vit + Vit C&e TabPharmavite Llc
Balanced B100Hall Laboratories, Ltd.
Balanced B50 ComplexHall Laboratories, Ltd.
Beautel Supplement De Vitamines Et MineralNobel Pharm Enr.
Beminal W C Fortis InjAyerst Laboratories
Beminal With C Fortis CapWyeth Ayerst Canada Inc.
Beminal With C Fortis PwsWyeth Ayerst Canada Inc.
Bev B-150Beverly International Nutrition
Bio-fenLisa & Gerry Freundl
Bugs Bunny and Friends Multiple VitaminsBayer Inc Consumer Care
Bugs Bunny Chew Multi Vit Plus IronMiles Canada Inc. Consumer Health Care Division
C 106 TabNf Formulas Inc.
C-apnto-B6 Vitamins W Magnesium TabMetagenics, Inc.
C-B ComplexAvacare, Division Of Jeunique International Inc.
C-forcePrairie Naturals
C-nate DHACenturion Labs, Llc
C.A.G. TabNutrition For Life International
C.R.T. X Multivitamin & Mineral Powder MixMetaform Ltd.
Cal M TabAnabolic Laboratories Inc.
Calcium Folic Acid Plus D ChewableAcella Pharmaceuticals, LLC
CarbawayAbundance Marketing Ltd.
Carthaphy CapProduits Phyto Inc.
Cda-21 Vitamins With Non-medicinal Probiotic ComplexRx Vitamins Inc.
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Chela Zinc PlusNu Life Nutrition Ltd.
Chew.multiple Vits.with Extra C for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vit Plus Iron for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Extra CRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Iron TabRandle Pharmaceutical Inc.
Chewable Multiple Vitamins TabRandle Pharmaceutical Inc.
Chewable MultivitaminsWn Pharmaceuticals Ltd.
Chewable Multivitamins Plus IronWn Pharmaceuticals Ltd.
Children's Chewable Multi Vit W IronShoppers Drug Mart Inc.
Children's Chewable Multi VitaminsShoppers Drug Mart Inc.
Children's Chewable Multi Vitamins With Iron TabletsVita Health Products Inc
Children's Chewable Multi-vitaminWn Pharmaceuticals Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Multiple Vit.plus IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins - TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)Pharmetics (2011) Inc
Children's Vitamins ChewableVita Health Products Inc
Children's Vitamins W Iron ChewableVita Health Products Inc
Childrens Chew Multi Vitamin TabNutristar Health Products (1987) Inc.
Childrens Chewable Multiple VitaminsKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins Plus FeKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins TabPharmavite Llc
Childrens Chewable MultivitaminsRandle Labs Inc.
Childrens Chewable Multivitamins W IronRandle Labs Inc.
Childrens Chewable Vitamin TabPharmetics (2011) Inc
Childrens Chewable VitaminsD.C. Labs Limited
Childrens Multiple Vit and Min Chew TabCountry Health Laboratories Ltd.
Citranatal B-calmMission Pharmacal Company
Citranatal DHAMission Pharmacal Company
Citranatal Harmony 3.0Mission Pharmacal Company
Citranatal RxMission Pharmacal Company
Complete Mega BGahler Enterprises Ltd.
Complex-75Frega Inc.
Complexe B 75mgPharmalab Inc.
Complexe B Compose 75Les Laboratoires Bio SantÉ Inc.
Complexe B-75Frega Inc.
Concept DHAUs Pharmaceutical Corporation
Concept ObUs Pharmaceutical Corporation
Croq-vit Pour EnfantsNutrivac Ltee
CyroplexTherapeutic Foods Co.
Daily Energy Brand B-complexEnzymatic Therapy (Canada) Inc.
Dermagran Moisturizing SprayCanadian Medical Supply Inc.
Dia-viteR & D Laboratories Inc.
DiaplexNephro Tech, Inc.
DiclectinDuchesnay Inc
DiclegisDuchesnay Usa, Inc.
DivistaUs Pharmaceutical Corporation
Dp 2000Pep Products Inc.
Dynam Ampoule Et TabletCardinaux Enrg Les Produits Naturels
E.V.C. Vitamins TabSisu Inc.
Efferlife Multivitamins and MineralsNaturale Science Inc.
Energy 80 Prolonged Release TabSportscience Labs Inc.
Enviroflex - TabEnviro Tech International Canada
EscaviteGm Pharmaceuticals, Inc.
Essential B TabletsGeneral Nutrition Canada Inc.
Evc - LiqSisu Inc.
Evc Liquid Vitamins A,c,b6 With Beta Caro&znNf Formulas Inc.
Everyday Multiple VitaminsD.C. Labs Limited
Everyday Multiple Vitamins With IronD.C. Labs Limited
Extra-virt Plus DHAVirtus Pharmaceuticals LLC
Ez-flexMetagenics, Inc.
Fabb TabletsMidlothian Laboratories
Fem - ControlMetagenics, Inc.
Fem - F.S. FormulaMetagenics, Inc.
Fem - PmtMetagenics, Inc.
Feminex 300 TabSantÉ Naturelle (Ag) LtÉe
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Femitab TabLe Groupe Prodeal Ltee
Ferra Naka Plus VitaminsNaka Sales Ltd.
Flinstones Multiple Plus IronMiles Canada Inc. Consumer Health Care Division
Flintstones Multiple VitaminsBayer Inc Consumer Care
Flintstones Multiple Vitamins Plus IronBayer Inc Consumer Care
Flintstones Multiple Vitamins TabMiles Canada Inc. Consumer Health Care Division
Flintstones W Extra C TabMiles Canada Inc. Consumer Health Care Division
Floradix Formula LiqFlora Manufacturing And Distributing Ltd.
Floravit - SyrFlora Manufacturing And Distributing Ltd.
FlorivaBon Geo Pharmaceuticals, Inc.
Floriva PlusBon Geo Pharmaceuticals, Inc.
FolbicNcs Health Care Of Ky, Inc Dba Vangard Labs
FolcapsMidlothian Laboratories
Folcaps Care OneMidlothian Laboratories
Folcaps Omega-3Midlothian Laboratories
Folet OnePronova Corporation
Foltabs 800Midlothian Laboratories
Foltabs PrenatalMidlothian Laboratories
For Kids Only Chewable Multivit. Plus IronKsl Pharmaceuticals
For Kids Only Chewable Multivitamins - TabKsl Pharmaceuticals
Formula 6100 CapStandard Process Inc.
Formula Adr-vitamin B2,b6 W Calpan TabMetagenics, Inc.
Formula BPNutrivention Nutritional Products
Formula Ch. Les.Abundance Marketing Ltd.
Formula CmNutrivention Nutritional Products
Formula CnBalance Plus, Inc.
Formula D.S.Golden Pride International
Formula Est'ro Tab SupportBalance Plus, Inc.
Formula Fm Vitamins & Minerals TabMetagenics, Inc.
Formula Im-vitamins and Minerals TabMetagenics, Inc.
Formula JsNutrivention Nutritional Products
Formula LfNumark Laboratories, Inc.
Formula O-care Vitamin and Mineral SupplementFor Mor International Inc.
Formula Pro-BBalance Plus, Inc.
Formula R TabMetagenics, Inc.
Formula WbNutrivention Nutritional Products
Fortamines 10 CapsulesRougier Pharma Division Of Ratiopharm Inc
Fortamines-10 ComprimesRougier Pharma Division Of Ratiopharm Inc
Fortaplex InjKripps Pharmacy Ltd.
Fortistress TabSantÉ Naturelle (Ag) LtÉe
Forty Plus Vitamin SupplementGarden State Nutritionals
Fusion Activator Formula TabL & S Research Corporation
Garfield Chewable Multivits Plus Iron TabWhitehall Robins Inc.
Geritol LiquidGlaxosmithkline Consumer Healthcare Inc.
Gestamine ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
H. Formula - TabAbundance Marketing Ltd.
Harvest Of Values All B Complex TabHillestad Pharmaceuticals Usa
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemenatal ObWh Nutritionals, Llc
Hi Potency B Complex W Chelated MineralsKlaire Labs Inc.
Hi Potency B52 B Complex TabCountry Health Laboratories Ltd.
Hi Potency Balanced B-100 Complex - TabLeiner Health Products Inc.
Hi Potency Stress B Tension With CLee Adams Laboratories
High Potency Vitamin B Complex + C TabVita Health Products Inc
Hill.viteHillestad Pharmaceuticals Usa
Homosistrol CapsulesMacromed Pharmicia Inc.
Hypo Vites TabPharmetics (2011) Inc
Iberet 500Abbott Laboratories, Limited
Inatal AdvanceNnodum Pharmaceuticals
Inatal UltraNnodum Pharmaceuticals
Infantol DropsChurch & Dwight Canada Corp
Insur-all Vitamin SupplementGarden State Nutritionals
Integra PlusUs Pharmaceutical Corporation
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoQuest Vitamins A Div Of Purity Life Health Products
Iron Polysaccharides Folic Acid DHAVirtus Pharmaceuticals LLC
Iron Vitamins B6,b12,c,folic Acid TabLaboratoire Lalco Inc.
Isotamine B 300Valeant Canada Lp Valeant Canada S.E.C.
Isotonix Advanced B-complex Vitamins With Potassium and MagnesiumMarket America, Inc.
Kanga Sport Vitamins B & C Plus MineralsLacombe Drugs (1992) Ltd
Kanga-B Vitamin B Group + CLacombe Drugs (1992) Ltd
Kanga-kid Multi-vitamin & MineralLacombe Drugs (1992) Ltd
Kanga-kid Vitamins & IronLacombe Drugs (1992) Ltd
Kanga-V Multivitamins & MineralsLacombe Drugs (1992) Ltd
Kenwood Liquid SupplementKenwood Laboratories (Division Of Bradley Pharmaceuticals)
Kid's Choice Children's Chewable Vitamins - TabVita Health Products Inc
Kidmag Vitamins W Magnesium TabMetagenics, Inc.
Kids Stuff TabletsVita Health Products Inc
Kids Stuff With Iron TabletsVita Health Products Inc
Kimchi Vitamin Chewable MultivitaminTobico
KindervitesHerbalife International Of America, Inc.
Kmg PlusSeroyal International Inc.
Lipo-B-C TabMetagenics, Inc.
LipovitanP.S.W.C. Co., Inc.
Liqui B ComplexTwin Laboratories Inc.
Liqui B Complex PlusTwin Laboratories Inc.
Liqui Infant VitaminsTwin Laboratories Inc.
Liqui VitaTwin Laboratories Inc.
Liquid B Complex 50Jamieson Laboratories Ltd
Livron Plus AmpouleMedic Laboratory LtÉe
Livron Plus TabMedic Laboratory LtÉe
Low Potency B Complex TabFlora Manufacturing And Distributing Ltd.
Lysamine Diet Supp Amp-tabWelcker Lyster Ltd., Division Of Technilab Inc.
M.V.I. 12Aventis Pharma Inc
M.V.I. PaediatricAventis Pharma Inc
M.V.I. PediatricHospira Worldwide, Inc.
Magnesium 50mg With Vitamin B6 TabJamieson Laboratories Ltd
Maltlevol 12 LiqCarter Horner Corp.
Maltlevol LiqCarter Horner Corp.
Maxi 10 TabDesbergers LtÉe, Division Of Technilab Inc.
Mega 13 Multivitamin FormulaVita Health Products Inc
Megavites TabIcn Canada Ltd.
Meplex T 750Medic Laboratory LtÉe
Meth-X Vitamin and Mineral SupplementDymatize Enterprises Inc.
Min-chex CapStandard Process Inc.
Mini-B TabTwin Laboratories Inc.
Mnps Formula SupplementGarden State Nutritionals
Mor-vites TabPharmetics (2011) Inc
Multi 12 InjectionSandoz Canada Incorporated
Multi BSeroyal International Inc.
Multi Enfants TabVitalab
Multi RolRolmex International Inc.
Multi Vitamin & MineralsWn Pharmaceuticals Ltd.
Multi Vitamin and FluorideLibertas Pharma, Inc.
Multi Vitamin Drops With FluorideSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride and IronSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride With IronStratus Pharmaceuticals
Multi Vitamin Plus IronWn Pharmaceuticals Ltd.
Multi Vitamin With FluorideQualitest Pharmaceuticals
Multi Vitamin, Iron and FluorideLibertas Pharma, Inc.
Multi Vitamins & MineralsWn Pharmaceuticals Ltd.
Multi Vite Liq AdultPharmetics (2011) Inc
Multi Vite Liq JuniorPharmetics (2011) Inc
Multi-11Sandoz Canada Incorporated
Multi-12 PediatricSabex Inc
Multi-12/k1 PediatricSandoz Canada Incorporated
Multi-vit With FluorideQualitest Pharmaceuticals
Multi-vit With Fluoride and IronQualitest Pharmaceuticals
Multi-vitaminLLC Federal Solutions
Multi-vitamin FluorideStratus Pharmaceuticals
Multi-vitamin Fluoride and Iron DropsBoca Pharmacal, LLC
Multi-vitamin Fluoride DropsH.J. Harkins Company, Inc.
Multi-vitamin With FluorideGolden State Medical Supply, Inc.
Multi-vitamines Enfants ComprimeHerbes Universelles Inc.
Multi-vitaminsWn Pharmaceuticals Ltd.
Multi-vitamins With MineralsWn Pharmaceuticals Ltd.
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamin TabAdams Labs Ltd.
Multiple VitaminsGfr Pharma Ltd.
Multiple Vitamins and Minerals TabRandle Labs Inc.
Multiple Vitamins Plus Iron for WomenPharmetics (2011) Inc
Multiple Vitamins Plus Iron TabHall Laboratories, Ltd.
Multiple Vitamins TabRandle Labs Inc.
Multiple Vitamins W Iron TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins W Minerals TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc
MultisolLes Laboratoires Vachon Inc.
Multivit-liqPharmalab Inc.
MultivitaminLaboratoires Confab Inc
Multivitamin With FluorideSancilio & Company Inc
MultivitaminesRolmex International Inc.
Multivitamines Et MinerauxLe Groupe M. Vachon Inc.
Multivitamines Plus Fer Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamines Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
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NephrocapsCardinal Health
Nexa PlusUpsher Smith Laboratories, Inc.
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Perioe Lucky Fresh - Cavity CareLG Household and Healthcare, Inc.
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Pnv Prenatal Vitamin Plus Vitamin ASancilio & Company Inc
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Prefera Ob Plus DHAAlaven Pharmaceutical LLC
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Prenate RestoreAvion Pharmaceuticals, Llc
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Surbex 500 FilmtabAbbott Laboratories, Limited
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Virt-bal DHA PlusVirtus Pharmaceuticals
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Salts
Name/CASStructureProperties
Pyridoxine hydrochloride
58-56-0
Thumb
  • InChI Key: ZUFQODAHGAHPFQ-UHFFFAOYSA-N
  • Monoisotopic Mass: 205.050570962
  • Average Mass: 205.639
DBSALT000151
Categories
UNIIKV2JZ1BI6Z
CAS number65-23-6
WeightAverage: 169.1778
Monoisotopic: 169.073893223
Chemical FormulaC8H11NO3
InChI KeyInChIKey=LXNHXLLTXMVWPM-UHFFFAOYSA-N
InChI
InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
IUPAC Name
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
SMILES
CC1=C(O)C(CO)=C(CO)C=N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pyridoxines. These are pyridoxal derivatives in which the carbaldehyde group at position 2 of the pyridoxal moiety is replaced by a hydroxymethyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPyridoxines
Direct ParentPyridoxines
Alternative Parents
Substituents
  • Pyridoxine
  • Methylpyridine
  • Hydroxypyridine
  • Heteroaromatic compound
  • Azacycle
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
PharmacodynamicsVitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Mechanism of actionVitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Related Articles
AbsorptionThe B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
Volume of distributionNot Available
Protein binding22%
Metabolism

Hepatic.

Route of eliminationNot Available
Half life15-20 days
ClearanceNot Available
ToxicityOral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
HypophosphatasiaDiseaseSMP00503
Vitamin B6 MetabolismMetabolicSMP00017
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9728
Blood Brain Barrier+0.6889
Caco-2 permeable-0.8958
P-glycoprotein substrateNon-substrate0.5579
P-glycoprotein inhibitor INon-inhibitor0.9723
P-glycoprotein inhibitor IINon-inhibitor0.9221
Renal organic cation transporterNon-inhibitor0.8177
CYP450 2C9 substrateNon-substrate0.7386
CYP450 2D6 substrateNon-substrate0.781
CYP450 3A4 substrateNon-substrate0.7104
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8648
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.695
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9418
BiodegradationNot ready biodegradable0.5678
Rat acute toxicity1.6573 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8454
hERG inhibition (predictor II)Non-inhibitor0.8734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Eli lilly and co
  • Akorn inc
  • App pharmaceuticals llc
  • Bel mar laboratories inc
  • Dell laboratories inc
  • Elkins sinn div ah robins co inc
  • Luitpold pharmaceuticals inc
  • Watson laboratories inc
Packagers
Dosage forms
FormRouteStrength
Liquid; capsuleoral
Elixiroral
Tablet (extended-release)oral500 mg
Injection, solutionintramuscular; intravenous
Tablet (extended-release)400 mg
Powder for solutionintramuscular; intravenous
Powder for solutionintravenous
Waferoral
Tabletoral2 mg
Tabletoral
Spraytopical
Tablet (delayed-release)oral
Tablet, delayed releaseoral
Tablet (extended-release)oral
Syruporal
Tabletoral8.45 mg
Liquidintramuscular; intravenous
Powderoral
Dropsoral
Tabletoral6 mg
Tabletoral8.33 mg
Tabletoral10 mg
Liquidintravenous
Injection, powder, lyophilized, for solutionintravenous
Liquid; tabletoral
Solution/ dropsoral
Solutionintravenous
Liquidoral
Solutionoral
Tablet, chewableoral
Capsule, gelatin coatedoral
Solutionintramuscular; intravenous
Capsuleoral
Pastedental
Tablet, coatedoral
Liquidintramuscular; intravenous100 mg
Tablet100 mg
Injection, solutionintramuscular; intravenous100 mg/mL
Solutionintramuscular; intravenous100 mg
Tablet (effervescent)oral
Powder for solutionoral
Capsule (sustained-release)oral
Kit
Tablet (extended-release)
Tablet (extended-release)100 mg
Tabletoral50 mg
Capsuleoral250 mg
Tablet
Capsule, liquid filledoral
Injectionintravenous
Capsule
Capsuleoral100 mg
Tabletoral17 mg
Capsuleoral200 mg
Tabletoral200 mg
Capsuleoral3.5 mg
Tabletoral250 mg
Tabletoral100 mg
Tabletoral25 mg
Tablet, film coatedoral
Lozengeoral
Prices
Unit descriptionCostUnit
Pyridoxine HCl 100 50 mg tablet Bottle12.99USD bottle
Pyridoxine HCl 100 mg/ml vial11.69USD vial
Pyridoxine 100 mg/ml vial10.79USD ml
Pyridoxine hcl crystals6.94USD g
Pyridoxine 500 mg tablet0.18USD tablet
Pyridoxine 25 mg tablet0.14USD tablet
Neuro k 500 mg tablet0.13USD tablet
Pyridoxine 250 mg tablet0.13USD tablet
CVS Pharmacy vitamin b-6 200 mg tablet0.07USD tablet
Neuro-k 250 mg tablet0.06USD tablet
Pyridoxine 50 mg tablet0.06USD tablet
Vitamin b-6 100 mg tablet0.04USD tablet
CVS Pharmacy vitamin b-6 100 mg tablet0.03USD tablet
Pyridoxine 100 mg tablet0.03USD tablet
Vitamin b6 50 mg tablet0.03USD tablet
Vitamin b-6 50 mg tablet0.03USD tablet
CVS Pharmacy vitamin b-6 50 mg tablet0.02USD tablet
Vitamin b-6 25 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6340695 No2001-06-212021-06-21Us
US7560122 No1999-01-252019-01-25Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point159-162 °CPhysProp
water solubility2.2E+005 mg/LNot Available
logP-0.77SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility16.1 mg/mLALOGPS
logP-0.57ALOGPS
logP-0.95ChemAxon
logS-1ALOGPS
pKa (Strongest Acidic)9.4ChemAxon
pKa (Strongest Basic)5.58ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area73.58 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity44.11 m3·mol-1ChemAxon
Polarizability17.11 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-000t-0940000000-30b4702623a6d8fcb4bbView in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)splash10-001j-0690000000-0581e2b42fa48c1ea498View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-00di-9330000000-32929ff06762b9f5887fView in MoNA
GC-MSGC-MS Spectrum - GC-MS (3 TMS)splash10-001i-0490000000-34a09ddbbb462aeb02a6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0vi0-0900000000-bd0de86c072765a5caadView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-3900000000-2018b406a3c75213b733View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0059-9200000000-e69bb531deb2a103a476View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-80) , Positivesplash10-0f6x-9400000000-77c43a946c4ae1abf3b9View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-014i-0900000000-479d4492cc8d634fa366View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-0udi-0900000000-486d6a4e5e1a731b7c54View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-05fr-0900000000-4ef09ce9c04561a1085eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-0ab9-1900000000-3298adf6db36689d5d43View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-0a6r-7900000000-6711954ee96f08344434View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-00di-0900000000-234e90d43a7febd7a098View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-0udi-0900000000-137080765c0035b45258View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-001i-0900000000-882ee900a8bba08e2c7cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-003r-8900000000-e0e11797b63cea991d81View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-0059-9100000000-c25384179219411af02cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0ue9-0900000000-c0e149ce890192397b7fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0v4i-0900000000-f9f378af3d47ab006806View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0uk9-0900000000-eab5b3411261744df750View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0ue9-0900000000-cc4dc8719602182ef1ebView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-5900000000-1c2637733578fcdd7c6aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0900000000-e89cc69d8b21012ff982View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-059i-0900000000-0ad8d09e042015cb2e33View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-9500000000-577a3d87899ca47d539fView in MoNA
MSMass Spectrum (Electron Ionization)splash10-1003-6900000000-1237eaf82dfadfd54d4bView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Harumi Kita, “Production of pyridoxine.” U.S. Patent US4339586, issued October, 1972.

US4339586
General ReferencesNot Available
External Links
ATC CodesA11HA02
AHFS Codes
  • 88:08.00
  • 92:02.00*
PDB Entries
FDA labelNot Available
MSDSDownload (51.5 KB)
Interactions
Drug Interactions
Drug
AltretamineThe therapeutic efficacy of Altretamine can be decreased when used in combination with Pyridoxine.
AmobarbitalThe metabolism of Amobarbital can be increased when combined with Pyridoxine.
ButabarbitalThe metabolism of Butabarbital can be increased when combined with Pyridoxine.
ButethalThe metabolism of Butethal can be increased when combined with Pyridoxine.
FosphenytoinThe metabolism of Fosphenytoin can be increased when combined with Pyridoxine.
HeptabarbitalThe metabolism of Heptabarbital can be increased when combined with Pyridoxine.
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Pyridoxine.
LevodopaThe therapeutic efficacy of Levodopa can be decreased when used in combination with Pyridoxine.
MethohexitalThe metabolism of Methohexital can be increased when combined with Pyridoxine.
PentobarbitalThe metabolism of Pentobarbital can be increased when combined with Pyridoxine.
PhenobarbitalThe metabolism of Phenobarbital can be increased when combined with Pyridoxine.
PhenytoinThe metabolism of Phenytoin can be increased when combined with Pyridoxine.
PrimidoneThe metabolism of Primidone can be increased when combined with Pyridoxine.
SecobarbitalThe metabolism of Secobarbital can be increased when combined with Pyridoxine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
ligand
General Function:
Zinc ion binding
Specific Function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Gene Name:
PDXK
Uniprot ID:
O00764
Molecular Weight:
35102.105 Da
References
  1. Adams JB, George F, Audhya T: Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006 Jan-Feb;12(1):59-63. [PubMed:16494569 ]
  2. Newman JA, Das SK, Sedelnikova SE, Rice DW: The crystal structure of an ADP complex of Bacillus subtilis pyridoxal kinase provides evidence for the parallel emergence of enzyme activity during evolution. J Mol Biol. 2006 Oct 20;363(2):520-30. Epub 2006 Aug 12. [PubMed:16978644 ]
  3. Kim SY, An JJ, Kim DW, Choi SH, Lee SH, Hwang SI, Kwon OS, Kang TC, Won MH, Cho SW, Park J, Eum WS, Lee KS, Choi SY: Tat-mediated protein transduction of human brain pyridoxine-5-P oxidase into PC12 cells. J Biochem Mol Biol. 2006 Jan 31;39(1):76-83. [PubMed:16466641 ]
  4. Nagahashi Y, Tazoe M, Hoshino T: Cloning of the pyridoxine 5'-phosphate phosphatase gene (pdxP) and vitamin B6 production in pdxP recombinant Sinorhizobium meliloti. Biosci Biotechnol Biochem. 2008 Feb;72(2):421-7. Epub 2008 Feb 7. [PubMed:18256491 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Tangjarukij C, Navasumrit P, Zelikoff JT, Ruchirawat M: The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. J Immunotoxicol. 2009 Sep;6(3):147-60. doi: 10.1080/15476910903083866. [PubMed:19637937 ]
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Drug created on June 13, 2005 07:24 / Updated on May 25, 2016 02:16