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Identification
Name Calcium Gluceptate
Accession Number DB00326 (APRD00841)
Type small molecule
Groups approved
Description

Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly.
Structure Thumb
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Display: 2D Structure | 3D Structure
Synonyms
  • Calcium glucoheptonate
  • Trimethylene chlorobromide
Brand names
  • Calcium Stanley
Brand name mixtures Not Available
Categories
  • Antihypocalcemic Agents
  • Antihypermagnesemic Agents
  • Electrolyte replenisher
  • Nutritional supplement, mineral
CAS number 29039-00-7
Weight Average: 490.425
Monoisotopic: 490.084675939
Chemical Formula C14H26CaO16
InChI Key InChIKey=FATUQANACHZLRT-KMRXSBRUSA-L
InChI
InChI=1S/2C7H14O8.Ca/c2*8-1-2(9)3(10)4(11)5(12)6(13)7(14)15;/h2*2-6,8-13H,1H2,(H,14,15);/q;;+2/p-2/t2*2-,3-,4+,5-,6?;/m11./s1
Plain Text
IUPAC Name
calcium bis((3R,4S,5R,6R)-2,3,4,5,6,7-hexahydroxyheptanoate)
SMILES
[Ca++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Organic
Classes
  • Carbohydrates
Substructures
  • Glycerol and Derivatives
  • Hydroxy Compounds
  • Anions
  • Acetates
  • Short-chain Hydroxy Acids
  • Carboxylic Acids and Derivatives
  • Alcohols and Polyols
  • Carbohydrates
  • Cations
Pharmacology
Indication For treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes.
Pharmacodynamics Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly. The bones serve as a storage site for the body's calcium. They are continuously giving up calcium to the bloodstream and then replacing it as the body's need for calcium changes from day to day. When there is not enough calcium in the blood to be used by the heart and other organs, your body will take the needed calcium from the bones. When you eat foods rich in calcium, the calcium will be restored to the bones and the balance between your blood and bones will be maintained.
Mechanism of action Calcium gluceptate replenishes the deminished levels of calcium in the body, returning them to normal levels.
Absorption Rapidly absorbed following oral administration.
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Symptoms of overdose include confusion, drowsiness (severe), high blood pressure, increased sensitivity of eyes or skin to light, irregular, fast, or slow heartbeat, and unusually large amount of urine or increased frequency of urination.
Affected organisms
  • Humans and other mammals
Pathways Not Available
Pharmacoeconomics
Manufacturers
  • Abbott laboratories pharmaceutical products div
  • Abraxis pharmaceutical products
  • Eli lilly and co
Packagers
Dosage forms
Form Route Strength
Solution Intravenous
Solution Oral
Prices
Unit description Cost Unit
Calcium gluceptate powder 12.69 USD g
Patents Not Available
Properties
State solid
Melting point Not Available
Experimental Properties
Property Value Source
water solubility Soluble PhysProp
Predicted Properties
Property Value Source
water solubility 3.98e+01 g/l ALOGPS
logP -1.91 ALOGPS
logP -4.04 ChemAxon Molconvert
logS -1.09 ALOGPS
pKa 12.47 ChemAxon Molconvert
hydrogen acceptor count 8 ChemAxon Molconvert
hydrogen donor count 6 ChemAxon Molconvert
polar surface area 161.51 ChemAxon Molconvert
rotatable bond count 12 ChemAxon Molconvert
refractivity 55.07 ChemAxon Molconvert
polarizability 19.35 ChemAxon Molconvert
References
Synthesis Reference Not Available
General Reference
  1. Drop LJ, Cullen DJ: Comparative effects of calcium chloride and calcium gluceptate. Br J Anaesth. 1980 May;52(5):501-5. Pubmed
External Links
Resource Link
KEGG Drug D00934 Link_out
PubChem Compound 62859 Link_out
PubChem Substance 46507233 Link_out
ChemSpider 56591 Link_out
PharmGKB PA448734 Link_out
Drug Product Database 0 Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries Not Available
FDA label Not Available
MSDS show (68.6 KB)
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Comments
Drug created on June 13, 2005 07:24 / Updated on January 12, 2011 14:20

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