Showing BioInteractions for Indomethacin (DB00328)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Indomethacin is a Prostaglandin G/H synthase 1 inhibitor
1	Prostaglandin G/H synthase 1 inhibitors	Aceclofenac, Acetaminophen, Acetylsalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Cannabidiol, Carprofen, Choline magnesium trisalicylate, Dexibuprofen, Dexketoprofen, Diclofenac, Diethylcarbamazine, Diflunisal, Dihomo-gamma-linolenic acid, Droxicam, Etodolac, Fenoprofen, Flurbiprofen, Hyperforin, Ibuprofen, Icosapent, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Medical Cannabis, Mefenamic acid, Meloxicam, Mesalazine, Nabiximols, Nabumetone, Naproxen, Nepafenac, Nitroaspirin, Oxaprozin, Phenylbutazone, Piroxicam, Resveratrol, Salicylic acid, Salsalate, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Trolamine salicylate
2	Prostaglandin G/H synthase 1 inducers	Desmopressin, Minoxidil
3	Prostaglandin G/H synthase 1 substrates	Candesartan, Candesartan cilexetil, Chlorpropamide, Dapsone, Diazepam, Diphenhydramine, Dronabinol, Eletriptan, Etoposide, Hexobarbital, Ifosfamide, Imatinib, Irbesartan, Ketamine, Ketobemidone, Montelukast, Nateglinide, Rofecoxib, Rosiglitazone, Seratrodast, Terbinafine, Thalidomide, Trabectedin, Valproic acid, Voriconazole, Zafirlukast, Zaltoprofen, Zileuton, Zopiclone
4	Prostaglandin G/H synthase 1 antagonists	Acemetacin, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Tolfenamic acid, Triflusal

	Interacting Group	Interacting Drugs
	Indomethacin is a Prostaglandin G/H synthase 2 inhibitor
1	Prostaglandin G/H synthase 2 inhibitors	Aceclofenac, Acetaminophen, Acetylsalicylic acid, Aminosalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Cannabidiol, Capsaicin, Carprofen, Celecoxib, Chlorphenesin, Choline magnesium trisalicylate, Cimicoxib, Cisplatin, Clodronic acid, Dexibuprofen, Dexketoprofen, Diclofenac, Diflunisal, Drospirenone, Droxicam, Etodolac, Etoricoxib, Fenoprofen, Fish oil, Flurbiprofen, Ginseng, Ibuprofen, Icosapent, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Medical Cannabis, Mefenamic acid, Meloxicam, Mesalazine, Morniflumate, Nabiximols, Nabumetone, Naproxen, Nepafenac, Niflumic acid, Nimesulide, Oxaprozin, Parecoxib, Phenylbutazone, Piroxicam, Pomalidomide, Resveratrol, Rofecoxib, Salicylic acid, Salsalate, Seliciclib, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Triamcinolone, Trolamine salicylate, Valdecoxib
2	Prostaglandin G/H synthase 2 negative modulators	Lenalidomide
3	Prostaglandin G/H synthase 2 antagonists	Acemetacin, Alclofenac, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Thalidomide, Tolfenamic acid
4	Prostaglandin G/H synthase 2 substrates	Dapsone, Etoposide, Omega-3 fatty acids, Omega-6 fatty acids, Thalidomide
5	Prostaglandin G/H synthase 2 inducers	Aldesleukin, Bryostatin 1, Bumetanide, Desmopressin, Drospirenone, Nonoxynol-9, Prasterone sulfate, Risedronic acid, Sapropterin, Sar9, Met (O2)11-Substance P, Semaxanib, Tafluprost

	Interacting Group	Interacting Drugs
	Indomethacin is a Phospholipase A2, membrane associated inhibitor
1	Phospholipase A2, membrane associated inhibitors	Diclofenac, Ginkgo biloba, Suramin

	Interacting Group	Interacting Drugs
	Indomethacin is a Prostaglandin reductase 2 inhibitor

	Interacting Group	Interacting Drugs
	Indomethacin is a Lactoylglutathione lyase inhibitor

	Interacting Group	Interacting Drugs
	Indomethacin is a Peroxisome proliferator-activated receptor gamma activator
1	Peroxisome proliferator-activated receptor gamma agonists	Aleglitazar, Amiodarone, Balsalazide, Bezafibrate, Darglitazone, Flufenamic acid, Glipizide, Icosapent, Isoflavone, Mesalazine, Mitiglinide, Nateglinide, Pioglitazone, Repaglinide, Rosiglitazone, Sulfasalazine, Troglitazone
2	Peroxisome proliferator-activated receptor gamma partial agonists	AMG-131, Telmisartan
3	Peroxisome proliferator-activated receptor gamma activators	Cannabidiol, Dexibuprofen, Ibuprofen, Lobeglitazone
4	Peroxisome proliferator-activated receptor gamma ligands	Capric acid, Doconexent, Oleic Acid, Omega-3 fatty acids
5	Peroxisome proliferator-activated receptor gamma modulators	Clofazimine

	Interacting Group	Interacting Drugs
	Indomethacin is a Peroxisome proliferator-activated receptor alpha agonist
1	Peroxisome proliferator-activated receptor alpha agonists	Aleglitazar, Amiodarone, Bezafibrate, Cardarine, Clofibrate, Fenofibrate, Fenofibric acid, Gemfibrozil, Isoflavone, Myrrh
2	Peroxisome proliferator-activated receptor alpha activators	Fenoprofen, Flufenamic acid, Ibuprofen, Leukotriene B4, Omega-3 fatty acids, Prasterone, Soybean oil
3	Peroxisome proliferator-activated receptor alpha ligands	Doconexent

	Interacting Group	Interacting Drugs
	Indomethacin is a Aldo-keto reductase family 1 member C3 inhibitor
1	Aldo-keto reductase family 1 member C3 inducers	Androstenedione
2	Aldo-keto reductase family 1 member C3 substrates	Doxorubicin, Fenofibrate, Glycyrrhizic acid, Oxcarbazepine

	Interacting Group	Interacting Drugs
	Indomethacin is a Cytochrome P450 2C19 substrate
1	Cytochrome P450 2C19 substrates	(R)-warfarin, (S)-Warfarin, Acenocoumarol, Adinazolam, Albendazole, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Bupivacaine, Cannabidiol, Capravirine, Carisoprodol, Cenobamate, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clobazam, Clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Dexibuprofen, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Doxazosin, Doxepin, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esketamine, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Fedratinib, Fenfluramine, Flunitrazepam, Fluoxetine, Formoterol, Fosphenytoin, Gliclazide, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Hydrocodone, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Lonafarnib, Loratadine, Lorcaserin, Lorlatinib, Lovastatin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Methadone, Methsuximide, Methylene blue, Methylphenobarbital, Moclobemide, Nabiximols, Nebivolol, Nelfinavir, Nicotine, Nilutamide, Norethisterone, Nortriptyline, Oliceridine, Omeprazole, Ospemifene, Oxiconazole, Oxymetazoline, Pantoprazole, Paroxetine, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Pirfenidone, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Rilpivirine, Romidepsin, Rupatadine, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Simvastatin, St. John's Wort, Stiripentol, Tamoxifen, Tapentadol, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Triclabendazole, Trimethadione, Trimipramine, Valproic acid, Verapamil, Vilazodone, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Zolpidem, Zonisamide
2	Cytochrome P450 2C19 inhibitors	Abiraterone, Alpelisib, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Avasimibe, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Casimersen, Cenobamate, Chloramphenicol, Cimetidine, Cisapride, Citalopram, Clascoterone, Clevidipine, Clinafloxacin, Clozapine, Curcumin sulfate, Cyclosporine, Dabrafenib, Delavirdine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Duloxetine, Elexacaftor, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Esomeprazole, Ethambutol, Ethanol, Ethinylestradiol, Etoricoxib, Etravirine, Felbamate, Fenofibrate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gestodene, Idelalisib, Imipramine, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Letrozole, Lobeglitazone, Lonafarnib, Lopinavir, Loratadine, Losartan, Luliconazole, Lynestrenol, Manidipine, Memantine, Menadione, Mephenytoin, Methimazole, Methsuximide, Methylene blue, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Osilodrostat, Oxcarbazepine, Pantoprazole, Phenelzine, Piperaquine, Progesterone, Quinine, Rabeprazole, Rifamycin, Rilpivirine, Rucaparib, Safinamide, Seproxetine, Sertraline, Sildenafil, Sitaxentan, Somapacitan, Somatotropin, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Tirbanibulin, Topiramate, Topiroxostat, Tranylcypromine, Triclabendazole, Troglitazone, Ubrogepant, Valproic acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3	Cytochrome P450 2C19 inducers	Acetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Betamethasone, Budesonide, Carbamazepine, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enzalutamide, Hydrocortisone, Hydroxyprogesterone caproate, Letermovir, Lumacaftor, Methylprednisolone, Midostaurin, Nelfinavir, Norethisterone, Opicapone, Phenobarbital, Phenytoin, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, St. John's Wort

	Interacting Group	Interacting Drugs
	Indomethacin is a Cytochrome P450 2C19 inhibitor
1	Cytochrome P450 2C19 substrates	(R)-warfarin, (S)-Warfarin, Acenocoumarol, Adinazolam, Albendazole, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Bupivacaine, Cannabidiol, Capravirine, Carisoprodol, Cenobamate, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clobazam, Clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Dexibuprofen, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Doxazosin, Doxepin, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esketamine, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Fedratinib, Fenfluramine, Flunitrazepam, Fluoxetine, Formoterol, Fosphenytoin, Gliclazide, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Hydrocodone, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Lonafarnib, Loratadine, Lorcaserin, Lorlatinib, Lovastatin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Methadone, Methsuximide, Methylene blue, Methylphenobarbital, Moclobemide, Nabiximols, Nebivolol, Nelfinavir, Nicotine, Nilutamide, Norethisterone, Nortriptyline, Oliceridine, Omeprazole, Ospemifene, Oxiconazole, Oxymetazoline, Pantoprazole, Paroxetine, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Pirfenidone, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Rilpivirine, Romidepsin, Rupatadine, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Simvastatin, St. John's Wort, Stiripentol, Tamoxifen, Tapentadol, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Triclabendazole, Trimethadione, Trimipramine, Valproic acid, Verapamil, Vilazodone, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Zolpidem, Zonisamide
2	Cytochrome P450 2C19 inhibitors	Abiraterone, Alpelisib, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Avasimibe, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Casimersen, Cenobamate, Chloramphenicol, Cimetidine, Cisapride, Citalopram, Clascoterone, Clevidipine, Clinafloxacin, Clozapine, Curcumin sulfate, Cyclosporine, Dabrafenib, Delavirdine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Duloxetine, Elexacaftor, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Esomeprazole, Ethambutol, Ethanol, Ethinylestradiol, Etoricoxib, Etravirine, Felbamate, Fenofibrate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gestodene, Idelalisib, Imipramine, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Letrozole, Lobeglitazone, Lonafarnib, Lopinavir, Loratadine, Losartan, Luliconazole, Lynestrenol, Manidipine, Memantine, Menadione, Mephenytoin, Methimazole, Methsuximide, Methylene blue, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Osilodrostat, Oxcarbazepine, Pantoprazole, Phenelzine, Piperaquine, Progesterone, Quinine, Rabeprazole, Rifamycin, Rilpivirine, Rucaparib, Safinamide, Seproxetine, Sertraline, Sildenafil, Sitaxentan, Somapacitan, Somatotropin, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Tirbanibulin, Topiramate, Topiroxostat, Tranylcypromine, Triclabendazole, Troglitazone, Ubrogepant, Valproic acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3	Cytochrome P450 2C19 inducers	Acetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Betamethasone, Budesonide, Carbamazepine, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enzalutamide, Hydrocortisone, Hydroxyprogesterone caproate, Letermovir, Lumacaftor, Methylprednisolone, Midostaurin, Nelfinavir, Norethisterone, Opicapone, Phenobarbital, Phenytoin, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, St. John's Wort

	Interacting Group	Interacting Drugs
	Indomethacin is a UDP-glucuronosyltransferase 1-9 substrate
1	UDP-glucuronosyltransferase 1-9 substrates	Acetaminophen, Ambrisentan, Artenimol, Artesunate, Ataluren, Cabotegravir, Canagliflozin, Dabigatran etexilate, Dapagliflozin, Dexibuprofen, Diclofenac, Dolutegravir, Empagliflozin, Enasidenib, Entacapone, Ertugliflozin, Ethinylestradiol, Etodolac, Ezogabine, Febuxostat, Fenofibrate, Flurbiprofen, Formoterol, Fostamatinib, Gavestinel, Gemfibrozil, Glasdegib, Haloperidol, Ibuprofen, Irinotecan, Ketobemidone, Labetalol, Lumiracoxib, Mycophenolate mofetil, Mycophenolic acid, Naproxen, Nateglinide, Oxazepam, Oxymetazoline, Phenytoin, Propacetamol, Propofol, Regorafenib, Seratrodast, Sorafenib, Tapentadol, Topiroxostat, Troglitazone, Umifenovir, Vadimezan, Valdecoxib, Valproic acid, Vericiguat, Zileuton
2	UDP-glucuronosyltransferase 1-9 inhibitors	Deferasirox, Diflunisal, Eltrombopag, Fosphenytoin, Isavuconazole, Mefenamic acid, Methylene blue, Morniflumate, Niflumic acid, Phenytoin, Regorafenib, Rifampicin, Sorafenib, Umifenovir

	Interacting Group	Interacting Drugs
	Indomethacin is a Cytochrome P450 2C9 substrate
1	Cytochrome P450 2C9 inhibitors	Abemaciclib, Abiraterone, Acetyl sulfisoxazole, Agomelatine, Amiodarone, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atazanavir, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Black cohosh, Bortezomib, Candesartan, Capecitabine, Casimersen, Ceritinib, Cerivastatin, Cimetidine, Cisapride, Cisplatin, Clascoterone, Clevidipine, Clinafloxacin, Clopidogrel, Clotrimazole, Crisaborole, Curcumin, Curcumin sulfate, Cyclizine, Delavirdine, Dexloxiglumide, Diacerein, Diethylstilbestrol, Doconexent, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Epinephrine, Estrone sulfate, Ethambutol, Ethanol, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Imatinib, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Levofloxacin, Lifitegrast, Lobeglitazone, Lopinavir, Lumacaftor, Manidipine, Medical Cannabis, Medroxyprogesterone acetate, Mefenamic acid, Menadione, Methimazole, Methylene blue, Metronidazole, Miconazole, Midostaurin, Mifepristone, Modafinil, Nabilone, Nicardipine, Nifedipine, Nilotinib, Noscapine, Olanzapine, Opicapone, Oritavancin, Oxandrolone, Paroxetine, Pexidartinib, Phenylbutazone, Phenytoin, Pralsetinib, Pranlukast, Probenecid, Progesterone, Promethazine, Quinidine, Rabeprazole, Regorafenib, Rhein, Rifamycin, Rilpivirine, Rucaparib, Seproxetine, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Teniposide, Ticagrelor, Ticlopidine, Tienilic acid, Tirbanibulin, Tolcapone, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Ubrogepant, Valdecoxib, Valproic acid, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Zafirlukast, Zucapsaicin
2	Cytochrome P450 2C9 substrates	(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetohexamide, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Avanafil, Avapritinib, Azelastine, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Capecitabine, Capravirine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Clopidogrel, Clozapine, Coumarin, Cyclophosphamide, Dacomitinib, Dapagliflozin, Dapsone, Desogestrel, Dexibuprofen, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dorzolamide, Doxazosin, Doxepin, Dronabinol, Duloxetine, Eletriptan, Enasidenib, Enzalutamide, Erdafitinib, Esketamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Ethinylestradiol, Etodolac, Etoricoxib, Etravirine, Febuxostat, Fenfluramine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Haloperidol, Halothane, Hexobarbital, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Irbesartan, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Ketorolac, Lacosamide, Leflunomide, Lesinurad, Licofelone, Lidocaine, Lonafarnib, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Moclobemide, Montelukast, Nabiximols, Nabumetone, Naproxen, Nateglinide, Netupitant, Niclosamide, Nicotine, Norgestimate, Oliceridine, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Piperaquine, Pirfenidone, Piroxicam, Pitavastatin, Prasugrel, Primidone, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Ramelteon, Rimegepant, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Ruxolitinib, Salicylic acid, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Siponimod, Sitaxentan, Sulfamethoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Tranilast, Treprostinil, Tretinoin, Triclabendazole, Trifarotene, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Umbralisib, Umifenovir, Valdecoxib, Valproic acid, Valsartan, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3	Cytochrome P450 2C9 inducers	Alpelisib, Apalutamide, Aprepitant, Avatrombopag, Betamethasone, Bosentan, Budesonide, Carbamazepine, Dabrafenib, Dapsone, Delafloxacin, Enzalutamide, Fosaprepitant, Fosphenytoin, Hydrocortisone, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lumacaftor, Methylprednisolone, Midostaurin, Modafinil, Nelfinavir, Nevirapine, Nifedipine, Peginterferon alfa-2b, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Secobarbital, Vigabatrin, Warfarin
4	Cytochrome P450 2C9 inactivators	Suprofen

	Interacting Group	Interacting Drugs
	Indomethacin is a UDP-glucuronosyltransferase 1-1 substrate
1	UDP-glucuronosyltransferase 1-1 substrates	Abacavir, Acetaminophen, Alvocidib, Atorvastatin, Axitinib, Belinostat, Bictegravir, Binimetinib, Cabotegravir, Carvedilol, Cerivastatin, Deferasirox, Delafloxacin, Dexibuprofen, Dolutegravir, Eltrombopag, Elvitegravir, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethinylestradiol, Etoposide, Ezetimibe, Ezogabine, Febuxostat, Flurbiprofen, Fluvastatin, Fulvestrant, Furosemide, Fusidic acid, Gavestinel, Gemfibrozil, Glipizide, Indacaterol, Irinotecan, Ketoprofen, Labetalol, Letermovir, Levothyroxine, Liothyronine, Losartan, Lovastatin, Metronidazole, Migalastat, Minoxidil, Morphine, Muraglitazar, Mycophenolate mofetil, Mycophenolic acid, Naloxone, Naltrexone, Nintedanib, Norgestimate, Phenytoin, Propacetamol, Propofol, Raloxifene, Raltegravir, Sacituzumab govitecan, Selumetinib, Simvastatin, Suprofen, Tecovirimat, Tiagabine, Tramadol, Troglitazone, Valproic acid, Vericiguat, Zidovudine, Zonisamide
2	UDP-glucuronosyltransferase 1-1 inhibitors	Adenine, Atazanavir, Dacomitinib, Dasabuvir, Deferasirox, Eltrombopag, Enasidenib, Erlotinib, Ertugliflozin, Flunitrazepam, Flurbiprofen, Fostamatinib, Gemfibrozil, Glecaprevir, Indinavir, Ketoconazole, Nilotinib, Ombitasvir, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Probenecid, Propofol, Regorafenib, Rucaparib, Silibinin, Sodium aurothiomalate, Sorafenib, Ubrogepant, Valproic acid
3	UDP-glucuronosyltransferase 1-1 inducers	Carbamazepine, Desogestrel, Efavirenz, Ethinylestradiol, Nelfinavir, Phenobarbital, Phenytoin, Rifampicin, Testosterone propionate, Tipranavir, Zidovudine

	Interacting Group	Interacting Drugs
	Indomethacin is a UDP-glucuronosyltransferase 1-1 inhibitor
1	UDP-glucuronosyltransferase 1-1 substrates	Abacavir, Acetaminophen, Alvocidib, Atorvastatin, Axitinib, Belinostat, Bictegravir, Binimetinib, Cabotegravir, Carvedilol, Cerivastatin, Deferasirox, Delafloxacin, Dexibuprofen, Dolutegravir, Eltrombopag, Elvitegravir, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethinylestradiol, Etoposide, Ezetimibe, Ezogabine, Febuxostat, Flurbiprofen, Fluvastatin, Fulvestrant, Furosemide, Fusidic acid, Gavestinel, Gemfibrozil, Glipizide, Indacaterol, Irinotecan, Ketoprofen, Labetalol, Letermovir, Levothyroxine, Liothyronine, Losartan, Lovastatin, Metronidazole, Migalastat, Minoxidil, Morphine, Muraglitazar, Mycophenolate mofetil, Mycophenolic acid, Naloxone, Naltrexone, Nintedanib, Norgestimate, Phenytoin, Propacetamol, Propofol, Raloxifene, Raltegravir, Sacituzumab govitecan, Selumetinib, Simvastatin, Suprofen, Tecovirimat, Tiagabine, Tramadol, Troglitazone, Valproic acid, Vericiguat, Zidovudine, Zonisamide
2	UDP-glucuronosyltransferase 1-1 inhibitors	Adenine, Atazanavir, Dacomitinib, Dasabuvir, Deferasirox, Eltrombopag, Enasidenib, Erlotinib, Ertugliflozin, Flunitrazepam, Flurbiprofen, Fostamatinib, Gemfibrozil, Glecaprevir, Indinavir, Ketoconazole, Nilotinib, Ombitasvir, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Probenecid, Propofol, Regorafenib, Rucaparib, Silibinin, Sodium aurothiomalate, Sorafenib, Ubrogepant, Valproic acid
3	UDP-glucuronosyltransferase 1-1 inducers	Carbamazepine, Desogestrel, Efavirenz, Ethinylestradiol, Nelfinavir, Phenobarbital, Phenytoin, Rifampicin, Testosterone propionate, Tipranavir, Zidovudine

	Interacting Group	Interacting Drugs
	Indomethacin is a Liver carboxylesterase 1 substrate
1	Liver carboxylesterase 1 substrates	Capecitabine, Ciclesonide, Clopidogrel, Cocaine, Dabigatran etexilate, Fenofibrate, Homatropine, Irinotecan, Mycophenolate mofetil, Oseltamivir, Phenylacetic acid, Propoxycaine, Quinapril, Remdesivir, Remimazolam, Rufinamide, Selexipag, Tenofovir alafenamide, Trandolapril
2	Liver carboxylesterase 1 inhibitors	Benzocaine, Flupentixol, Mevastatin, Tamoxifen
3	Liver carboxylesterase 1 metabolizers	Filgotinib

	Interacting Group	Interacting Drugs
	Indomethacin is a UDP-glucuronosyltransferase 2B7 substrate
1	UDP-glucuronosyltransferase 2B7 substrates	Acemetacin, Ambrisentan, Anastrozole, Artenimol, Artesunate, Bempedoic acid, Carbamazepine, Carvedilol, Cenobamate, Codeine, Dabigatran etexilate, Dapagliflozin, Dexibuprofen, Dextromethorphan, Diclofenac, Empagliflozin, Enasidenib, Epirubicin, Ertugliflozin, Ethinylestradiol, Etodolac, Ezetimibe, Febuxostat, Flurbiprofen, Fluvastatin, Formoterol, Gemfibrozil, Hydromorphone, Ibuprofen, Ketorolac, Labetalol, Letrozole, Losartan, Lovastatin, Loxoprofen, Mitiglinide, Morphine, Mycophenolate mofetil, Mycophenolic acid, Nalmefene, Naproxen, Osilodrostat, Oxazepam, Pitavastatin, Silodosin, Simvastatin, Suprofen, Tamoxifen, Tapentadol, Troglitazone, Vadimezan, Valproic acid, Zaltoprofen, Zidovudine
2	UDP-glucuronosyltransferase 2B7 inhibitors	Chenodeoxycholic acid, Dovitinib, Flunitrazepam, Ketoconazole, Mefenamic acid, Umifenovir
3	UDP-glucuronosyltransferase 2B7 inducers	Phenobarbital

	Interacting Group	Interacting Drugs
	Indomethacin is a UDP-glucuronosyltransferase 2B7 inhibitor
1	UDP-glucuronosyltransferase 2B7 substrates	Acemetacin, Ambrisentan, Anastrozole, Artenimol, Artesunate, Bempedoic acid, Carbamazepine, Carvedilol, Cenobamate, Codeine, Dabigatran etexilate, Dapagliflozin, Dexibuprofen, Dextromethorphan, Diclofenac, Empagliflozin, Enasidenib, Epirubicin, Ertugliflozin, Ethinylestradiol, Etodolac, Ezetimibe, Febuxostat, Flurbiprofen, Fluvastatin, Formoterol, Gemfibrozil, Hydromorphone, Ibuprofen, Ketorolac, Labetalol, Letrozole, Losartan, Lovastatin, Loxoprofen, Mitiglinide, Morphine, Mycophenolate mofetil, Mycophenolic acid, Nalmefene, Naproxen, Osilodrostat, Oxazepam, Pitavastatin, Silodosin, Simvastatin, Suprofen, Tamoxifen, Tapentadol, Troglitazone, Vadimezan, Valproic acid, Zaltoprofen, Zidovudine
2	UDP-glucuronosyltransferase 2B7 inhibitors	Chenodeoxycholic acid, Dovitinib, Flunitrazepam, Ketoconazole, Mefenamic acid, Umifenovir
3	UDP-glucuronosyltransferase 2B7 inducers	Phenobarbital

	Interacting Group	Interacting Drugs
	Indomethacin is a Canalicular multispecific organic anion transporter 2 inhibitor
1	Canalicular multispecific organic anion transporter 2 inducers	Cisplatin, Metyrapone, Nifedipine, Omeprazole, Phenobarbital, Rifampicin
2	Canalicular multispecific organic anion transporter 2 inhibitors	Bempedoic acid, Cholic Acid, Conjugated estrogens, Doxorubicin, Etoposide, Glyburide, Methotrexate, Probenecid, Promethazine, Sulfinpyrazone, Taurocholic acid, Verapamil, Vincristine
3	Canalicular multispecific organic anion transporter 2 substrates	Belantamab mafodotin, Etoposide, Ezetimibe, Fexofenadine, Fluorouracil, Folic acid, Gadoxetic acid, Glutathione, Lamivudine, Methotrexate, Raloxifene, Taurocholic acid

	Interacting Group	Interacting Drugs
	Indomethacin is a Multidrug resistance-associated protein 4 inhibitor
1	Multidrug resistance-associated protein 4 substrates	Adefovir dipivoxil, Alprostadil, Atorvastatin, Cefazolin, Cyclic adenosine monophosphate, Dinoprostone, Fluciclovine (18F), Fluorouracil, Gadoxetic acid, Glutathione, Hydrochlorothiazide, Lamivudine, Mercaptopurine, Methotrexate, Nateglinide, Oseltamivir, Prasterone, Raloxifene, Rosuvastatin, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Zidovudine
2	Multidrug resistance-associated protein 4 inhibitors	Celecoxib, Cholic Acid, Conjugated estrogens, Cyclic adenosine monophosphate, Diclofenac, Dipyridamole, Flurbiprofen, Folic acid, Ibuprofen, Ketoprofen, Methotrexate, Probenecid, Promethazine, Remdesivir, Rofecoxib, Rucaparib, Sildenafil, Sorafenib, Sulfinpyrazone, Sunitinib, Taurocholic acid, Tioguanine, Ursodeoxycholic acid, Verapamil
3	Multidrug resistance-associated protein 4 binders	Meloxicam

	Interacting Group	Interacting Drugs
	Indomethacin is a Multidrug resistance-associated protein 6 inhibitor
1	Multidrug resistance-associated protein 6 inhibitors	Doxorubicin, Etoposide, Probenecid, Sulfinpyrazone, Vinblastine
2	Multidrug resistance-associated protein 6 substrates	Cisplatin, Dactinomycin, Daunorubicin, Doxorubicin, Etoposide, Teniposide

	Interacting Group	Interacting Drugs
	Indomethacin is a P-glycoprotein 1 substrate
1	P-glycoprotein 1 inducers	Acetylsalicylic acid, Aldosterone, Amiodarone, Amprenavir, Apalutamide, Atazanavir, Beclomethasone dipropionate, Betamethasone phosphate, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Colchicine, Cortisone acetate, Darunavir, Daunorubicin, Dexamethasone, Dexamethasone acetate, Diclofenac, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Hydrocortisone, Indinavir, Ivermectin, Levothyroxine, Liothyronine, Liotrix, Lopinavir, Lumacaftor, Methylprednisolone, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Phenobarbital, Platelet Activating Factor, Prednisolone phosphate, Prednisone, Progesterone, Propofol, Reserpine, Rifabutin, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Tipranavir, Trazodone, Vinblastine, Vincristine
2	P-glycoprotein 1 inhibitors	Abemaciclib, Acetaminophen, Afatinib, Alectinib, Alfentanil, Alpelisib, Amiodarone, Amlodipine, Amodiaquine, Amsacrine, Arsenic trioxide, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Axitinib, Azelastine, Azithromycin, Benzocaine, Bepridil, Berotralstat, Bicalutamide, Biricodar, Bisoprolol, Boceprevir, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carfilzomib, Carvedilol, Caspofungin, Ceftriaxone, Cethromycin, Cetirizine, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colforsin, Concanamycin A, Conivaptan, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dacomitinib, Dactinomycin, Darunavir, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexamethasone acetate, Dexniguldipine, Dexverapamil, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Dovitinib, Doxazosin, Doxorubicin, Dronabinol, Dronedarone, Duloxetine, Elacridar, Elagolix, Elbasvir, Elexacaftor, Emopamil, Enalapril, Enasidenib, Entrectinib, Enzalutamide, Erdafitinib, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Esomeprazole, Estramustine, Etoposide, Everolimus, Favipiravir, Fedratinib, Felodipine, Fentanyl, Fingolimod, Flibanserin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Galantamine, Gallopamil, Gefitinib, Genistein, Glasdegib, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Isavuconazole, Isavuconazonium, Istradefylline, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ketoconazole, Lamotrigine, Laniquidar, Lansoprazole, Lapatinib, Lasmiditan, Lenvatinib, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lonafarnib, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Lurbinectedin, Medroxyprogesterone acetate, Mefloquine, Megestrol acetate, Methadone, Methylene blue, Metronidazole, Mibefradil, Miconazole, Mifepristone, Mirabegron, Mitotane, Mitoxantrone, Naproxen, Nefazodone, Nelfinavir, Neratinib, Netupitant, Nicardipine, Niguldipine, Nilotinib, Nintedanib, Nisoldipine, Nitrendipine, Norethisterone, Norgestimate, Olaparib, Omeprazole, ONT-093, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Paroxetine, Pemigatinib, Pibrentasvir, Pimozide, Piperine, Polyethylene glycol, Polyethylene glycol 400, Ponatinib, Posaconazole, Pralsetinib, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Relugolix, Reserpine, Reversin 121, Rifamycin, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Salinomycin, Saquinavir, Sarecycline, Selegiline, Selpercatinib, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Tariquidar, Taurocholic acid, Telaprevir, Telmisartan, Temsirolimus, Tenofovir disoproxil, Tepotinib, Terazosin, Terfenadine, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Tezacaftor, Ticagrelor, Tipifarnib, Tipranavir, Tolvaptan, Trifluoperazine, Triflupromazine, Troleandomycin, Umbralisib, Upadacitinib, Valinomycin, Valspodar, Vandetanib, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voclosporin, Voxilaprevir, Zimelidine, Zonisamide, Zosuquidar
3	P-glycoprotein 1 substrates	Abemaciclib, Acebutolol, Acenocoumarol, Acetaminophen, Acetylsalicylic acid, Afatinib, Albendazole, Aldosterone, Alfuzosin, Aliskiren, Alitretinoin, alpha-Tocopherol acetate, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apremilast, Artesunate, Asunaprevir, Atazanavir, Atorvastatin, Avanafil, Avatrombopag, Axitinib, Azathioprine, Azithromycin, Baricitinib, Beclomethasone dipropionate, Belantamab mafodotin, Belinostat, Berotralstat, Betamethasone, Betamethasone phosphate, Betrixaban, Bisoprolol, Bortezomib, Bosutinib, Bromocriptine, Budesonide, Cabazitaxel, Cabergoline, Cabotegravir, Camptothecin, Canagliflozin, Capmatinib, Carfilzomib, Celecoxib, Ceritinib, Cerivastatin, Cethromycin, Cetirizine, Chloramphenicol succinate, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clindamycin, Clobazam, Clofazimine, Clomifene, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Cortisone acetate, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Daclatasvir, Dacomitinib, Dactinomycin, Dapagliflozin, Darolutamide, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquine, Dexamethasone, Dexamethasone acetate, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxepin, Doxorubicin, Duvelisib, Edoxaban, Elagolix, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Empagliflozin, Enasidenib, Enfortumab vedotin, Entrectinib, Epinastine, Erdafitinib, Erlotinib, Ertugliflozin, Erythromycin, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Everolimus, Ezetimibe, Fedratinib, Fesoterodine, Fexofenadine, Fidaxomicin, Filgotinib, Flecainide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fostemsavir, Gefitinib, Gemcitabine, Gilteritinib, Glasdegib, Glecaprevir, Gramicidin D, Grapiprant, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Hydroxyzine, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ixabepilone, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Larotrectinib, Lasmiditan, Ledipasvir, Lefamulin, Lemborexant, Lenalidomide, Lenvatinib, Letermovir, Letrozole, Levamlodipine, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Lonafarnib, Loperamide, Loratadine, Losartan, Lurbinectedin, Lusutrombopag, Medrysone, Mefloquine, Meperidine, Methotrexate, Methylene blue, Methylprednisolone, Metoclopramide, Mibefradil, Mirabegron, Mitoxantrone, Monensin, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nitrofurantoin, Nizatidine, Nortriptyline, Octreotide, Odanacatib, Olanzapine, Olaparib, Olopatadine, Omadacycline, Ombitasvir, Omeprazole, Opicapone, Osimertinib, Oxcarbazepine, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Panobinostat, Pantoprazole, Paritaprevir, Pazopanib, Pemigatinib, Pentazocine, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Platelet Activating Factor, Pomalidomide, Ponatinib, Posaconazole, Pralsetinib, Pravastatin, Prazosin, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Progesterone, Propranolol, Prucalopride, Quetiapine, Quinidine, Quinine, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Relugolix, Remdesivir, Reserpine, Revefenacin, Rhodamine 6G, Rifamycin, Rimegepant, Ripretinib, Risdiplam, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Selpercatinib, Selumetinib, Sildenafil, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Somatotropin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sulpiride, Sumatriptan, Tacrine, Tacrolimus, Talazoparib, Talinolol, Tamoxifen, Taurocholic acid, Tazemetostat, Technetium Tc-99m sestamibi, Tegaserod, Telaprevir, Temozolomide, Temsirolimus, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tepotinib, Testosterone propionate, Tezacaftor, Ticagrelor, Timolol, Tipranavir, Tolvaptan, Topiramate, Topotecan, Toremifene, Trastuzumab deruxtecan, Trastuzumab emtansine, Trilaciclib, Trimethoprim, Trimipramine, Tucatinib, Ubidecarenone, Ubrogepant, Umeclidinium, Upadacitinib, Valinomycin, Vardenafil, Vecuronium, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vericiguat, Vibegron, Vinblastine, Vincristine, Vinflunine, Vismodegib, Voclosporin, Voxilaprevir, Zanubrutinib, Zidovudine
4	P-glycoprotein 1 modulators	Acetylsalicylic acid, Avapritinib, Prazosin
5	P-glycoprotein 1 transporters	Ledipasvir, Tocopherol
6	P-glycoprotein 1 binders	Technetium Tc-99m tetrofosmin
7	P-glycoprotein 1 antagonists	Tocofersolan

	Interacting Group	Interacting Drugs
	Indomethacin is a P-glycoprotein 1 inhibitor
1	P-glycoprotein 1 inducers	Acetylsalicylic acid, Aldosterone, Amiodarone, Amprenavir, Apalutamide, Atazanavir, Beclomethasone dipropionate, Betamethasone phosphate, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Colchicine, Cortisone acetate, Darunavir, Daunorubicin, Dexamethasone, Dexamethasone acetate, Diclofenac, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Hydrocortisone, Indinavir, Ivermectin, Levothyroxine, Liothyronine, Liotrix, Lopinavir, Lumacaftor, Methylprednisolone, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Phenobarbital, Platelet Activating Factor, Prednisolone phosphate, Prednisone, Progesterone, Propofol, Reserpine, Rifabutin, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Tipranavir, Trazodone, Vinblastine, Vincristine
2	P-glycoprotein 1 inhibitors	Abemaciclib, Acetaminophen, Afatinib, Alectinib, Alfentanil, Alpelisib, Amiodarone, Amlodipine, Amodiaquine, Amsacrine, Arsenic trioxide, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Axitinib, Azelastine, Azithromycin, Benzocaine, Bepridil, Berotralstat, Bicalutamide, Biricodar, Bisoprolol, Boceprevir, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carfilzomib, Carvedilol, Caspofungin, Ceftriaxone, Cethromycin, Cetirizine, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colforsin, Concanamycin A, Conivaptan, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dacomitinib, Dactinomycin, Darunavir, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexamethasone acetate, Dexniguldipine, Dexverapamil, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Dovitinib, Doxazosin, Doxorubicin, Dronabinol, Dronedarone, Duloxetine, Elacridar, Elagolix, Elbasvir, Elexacaftor, Emopamil, Enalapril, Enasidenib, Entrectinib, Enzalutamide, Erdafitinib, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Esomeprazole, Estramustine, Etoposide, Everolimus, Favipiravir, Fedratinib, Felodipine, Fentanyl, Fingolimod, Flibanserin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Galantamine, Gallopamil, Gefitinib, Genistein, Glasdegib, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Isavuconazole, Isavuconazonium, Istradefylline, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ketoconazole, Lamotrigine, Laniquidar, Lansoprazole, Lapatinib, Lasmiditan, Lenvatinib, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lonafarnib, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Lurbinectedin, Medroxyprogesterone acetate, Mefloquine, Megestrol acetate, Methadone, Methylene blue, Metronidazole, Mibefradil, Miconazole, Mifepristone, Mirabegron, Mitotane, Mitoxantrone, Naproxen, Nefazodone, Nelfinavir, Neratinib, Netupitant, Nicardipine, Niguldipine, Nilotinib, Nintedanib, Nisoldipine, Nitrendipine, Norethisterone, Norgestimate, Olaparib, Omeprazole, ONT-093, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Paroxetine, Pemigatinib, Pibrentasvir, Pimozide, Piperine, Polyethylene glycol, Polyethylene glycol 400, Ponatinib, Posaconazole, Pralsetinib, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Relugolix, Reserpine, Reversin 121, Rifamycin, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Salinomycin, Saquinavir, Sarecycline, Selegiline, Selpercatinib, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Tariquidar, Taurocholic acid, Telaprevir, Telmisartan, Temsirolimus, Tenofovir disoproxil, Tepotinib, Terazosin, Terfenadine, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Tezacaftor, Ticagrelor, Tipifarnib, Tipranavir, Tolvaptan, Trifluoperazine, Triflupromazine, Troleandomycin, Umbralisib, Upadacitinib, Valinomycin, Valspodar, Vandetanib, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voclosporin, Voxilaprevir, Zimelidine, Zonisamide, Zosuquidar
3	P-glycoprotein 1 substrates	Abemaciclib, Acebutolol, Acenocoumarol, Acetaminophen, Acetylsalicylic acid, Afatinib, Albendazole, Aldosterone, Alfuzosin, Aliskiren, Alitretinoin, alpha-Tocopherol acetate, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apremilast, Artesunate, Asunaprevir, Atazanavir, Atorvastatin, Avanafil, Avatrombopag, Axitinib, Azathioprine, Azithromycin, Baricitinib, Beclomethasone dipropionate, Belantamab mafodotin, Belinostat, Berotralstat, Betamethasone, Betamethasone phosphate, Betrixaban, Bisoprolol, Bortezomib, Bosutinib, Bromocriptine, Budesonide, Cabazitaxel, Cabergoline, Cabotegravir, Camptothecin, Canagliflozin, Capmatinib, Carfilzomib, Celecoxib, Ceritinib, Cerivastatin, Cethromycin, Cetirizine, Chloramphenicol succinate, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clindamycin, Clobazam, Clofazimine, Clomifene, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Cortisone acetate, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Daclatasvir, Dacomitinib, Dactinomycin, Dapagliflozin, Darolutamide, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquine, Dexamethasone, Dexamethasone acetate, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxepin, Doxorubicin, Duvelisib, Edoxaban, Elagolix, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Empagliflozin, Enasidenib, Enfortumab vedotin, Entrectinib, Epinastine, Erdafitinib, Erlotinib, Ertugliflozin, Erythromycin, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Everolimus, Ezetimibe, Fedratinib, Fesoterodine, Fexofenadine, Fidaxomicin, Filgotinib, Flecainide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fostemsavir, Gefitinib, Gemcitabine, Gilteritinib, Glasdegib, Glecaprevir, Gramicidin D, Grapiprant, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Hydroxyzine, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ixabepilone, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Larotrectinib, Lasmiditan, Ledipasvir, Lefamulin, Lemborexant, Lenalidomide, Lenvatinib, Letermovir, Letrozole, Levamlodipine, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Lonafarnib, Loperamide, Loratadine, Losartan, Lurbinectedin, Lusutrombopag, Medrysone, Mefloquine, Meperidine, Methotrexate, Methylene blue, Methylprednisolone, Metoclopramide, Mibefradil, Mirabegron, Mitoxantrone, Monensin, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nitrofurantoin, Nizatidine, Nortriptyline, Octreotide, Odanacatib, Olanzapine, Olaparib, Olopatadine, Omadacycline, Ombitasvir, Omeprazole, Opicapone, Osimertinib, Oxcarbazepine, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Panobinostat, Pantoprazole, Paritaprevir, Pazopanib, Pemigatinib, Pentazocine, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Platelet Activating Factor, Pomalidomide, Ponatinib, Posaconazole, Pralsetinib, Pravastatin, Prazosin, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Progesterone, Propranolol, Prucalopride, Quetiapine, Quinidine, Quinine, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Relugolix, Remdesivir, Reserpine, Revefenacin, Rhodamine 6G, Rifamycin, Rimegepant, Ripretinib, Risdiplam, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Selpercatinib, Selumetinib, Sildenafil, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Somatotropin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sulpiride, Sumatriptan, Tacrine, Tacrolimus, Talazoparib, Talinolol, Tamoxifen, Taurocholic acid, Tazemetostat, Technetium Tc-99m sestamibi, Tegaserod, Telaprevir, Temozolomide, Temsirolimus, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tepotinib, Testosterone propionate, Tezacaftor, Ticagrelor, Timolol, Tipranavir, Tolvaptan, Topiramate, Topotecan, Toremifene, Trastuzumab deruxtecan, Trastuzumab emtansine, Trilaciclib, Trimethoprim, Trimipramine, Tucatinib, Ubidecarenone, Ubrogepant, Umeclidinium, Upadacitinib, Valinomycin, Vardenafil, Vecuronium, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vericiguat, Vibegron, Vinblastine, Vincristine, Vinflunine, Vismodegib, Voclosporin, Voxilaprevir, Zanubrutinib, Zidovudine
4	P-glycoprotein 1 modulators	Acetylsalicylic acid, Avapritinib, Prazosin
5	P-glycoprotein 1 transporters	Ledipasvir, Tocopherol
6	P-glycoprotein 1 binders	Technetium Tc-99m tetrofosmin
7	P-glycoprotein 1 antagonists	Tocofersolan

	Interacting Group	Interacting Drugs
	Indomethacin is a Multidrug resistance-associated protein 1 inhibitor
1	Multidrug resistance-associated protein 1 inhibitors	Abiraterone, Amprenavir, Atazanavir, Cannabidiol, Clofazimine, Conjugated estrogens, Daunorubicin, Diclofenac, Doxorubicin, Etoposide, Fingolimod, Genistein, Glutathione, Glyburide, Ibuprofen, Idarubicin, Indinavir, Ivermectin, Lamivudine, Medical Cannabis, Methotrexate, Mifepristone, Mitoxantrone, Myricetin, Nabiximols, Naringenin, Ofloxacin, Paclitaxel, Probenecid, Progesterone, Quercetin, Rifampicin, Ritonavir, Sulfinpyrazone, Taurocholic acid, Vandetanib, Vemurafenib, Verapamil, Vinblastine, Vincristine
2	Multidrug resistance-associated protein 1 inducers	Cholic Acid, Fingolimod, Phenobarbital, Quercetin, Ritonavir, Taurocholic acid, Vinblastine
3	Multidrug resistance-associated protein 1 substrates	Acemetacin, Aminohippuric acid, Atazanavir, Atorvastatin, Belantamab mafodotin, Dactinomycin, Daunorubicin, Docetaxel, Doxorubicin, Epirubicin, Etoposide, Fluorescein, Glutathione, Grepafloxacin, Irinotecan, Methotrexate, Mitoxantrone, Prasterone, Rhodamine 6G, Saquinavir, Saxagliptin, Technetium Tc-99m sestamibi, Trastuzumab deruxtecan, Vemurafenib, Vinblastine, Vincristine, Zoledronic acid

	Interacting Group	Interacting Drugs
	Indomethacin is a Solute carrier organic anion transporter family member 1A2 substrate
1	Solute carrier organic anion transporter family member 1A2 substrates	Aminohippuric acid, Atorvastatin, Bilastine, Budesonide, Bumetanide, Cholic Acid, Conjugated estrogens, Deoxycholic acid, Digoxin, Dinoprostone, Enalapril, Erythromycin, Fexofenadine, Glycochenodeoxycholic Acid, Levofloxacin, Levothyroxine, Lifitegrast, Liothyronine, Liotrix, Medrysone, Methotrexate, Mirabegron, Ouabain, Prasterone, Pravastatin, Rocuronium, Taurocholic acid, Ursodeoxycholic acid
2	Solute carrier organic anion transporter family member 1A2 inhibitors	Aldosterone, Betamethasone phosphate, Cholic Acid, Conjugated estrogens, Cortisone acetate, Deoxycholic acid, Dexamethasone, Dexamethasone acetate, Digitoxin, Erythromycin, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Everolimus, Glyburide, Glycochenodeoxycholic Acid, Hydrocortisone, Hydroxychloroquine, Ibuprofen, Indinavir, Ketoprofen, Lovastatin, Methyltestosterone, Naloxone, Naproxen, Nelfinavir, Ouabain, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Probenecid, Quinidine, Quinine, Rifampicin, Rifamycin, Ritonavir, Saquinavir, Simvastatin, Spironolactone, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tolbutamide, Ursodeoxycholic acid, Verapamil
3	Solute carrier organic anion transporter family member 1A2 inducers	Cholic Acid, Methyltestosterone, Sumatriptan, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid

	Interacting Group	Interacting Drugs
	Indomethacin is a Solute carrier organic anion transporter family member 1A2 inhibitor
1	Solute carrier organic anion transporter family member 1A2 substrates	Aminohippuric acid, Atorvastatin, Bilastine, Budesonide, Bumetanide, Cholic Acid, Conjugated estrogens, Deoxycholic acid, Digoxin, Dinoprostone, Enalapril, Erythromycin, Fexofenadine, Glycochenodeoxycholic Acid, Levofloxacin, Levothyroxine, Lifitegrast, Liothyronine, Liotrix, Medrysone, Methotrexate, Mirabegron, Ouabain, Prasterone, Pravastatin, Rocuronium, Taurocholic acid, Ursodeoxycholic acid
2	Solute carrier organic anion transporter family member 1A2 inhibitors	Aldosterone, Betamethasone phosphate, Cholic Acid, Conjugated estrogens, Cortisone acetate, Deoxycholic acid, Dexamethasone, Dexamethasone acetate, Digitoxin, Erythromycin, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Everolimus, Glyburide, Glycochenodeoxycholic Acid, Hydrocortisone, Hydroxychloroquine, Ibuprofen, Indinavir, Ketoprofen, Lovastatin, Methyltestosterone, Naloxone, Naproxen, Nelfinavir, Ouabain, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Probenecid, Quinidine, Quinine, Rifampicin, Rifamycin, Ritonavir, Saquinavir, Simvastatin, Spironolactone, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tolbutamide, Ursodeoxycholic acid, Verapamil
3	Solute carrier organic anion transporter family member 1A2 inducers	Cholic Acid, Methyltestosterone, Sumatriptan, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid

	Interacting Group	Interacting Drugs
	Indomethacin is a Solute carrier family 22 member 6 substrate
1	Solute carrier family 22 member 6 inhibitors	Acamprosate, Acetazolamide, Acetylsalicylic acid, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acamprosate, Acetylcysteine, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine

	Interacting Group	Interacting Drugs
	Indomethacin is a Solute carrier family 22 member 6 inhibitor
1	Solute carrier family 22 member 6 inhibitors	Acamprosate, Acetazolamide, Acetylsalicylic acid, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acamprosate, Acetylcysteine, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine

	Interacting Group	Interacting Drugs
	Indomethacin is a Solute carrier family 22 member 8 inhibitor
1	Solute carrier family 22 member 8 inhibitors	Acetylsalicylic acid, Acyclovir, Aminohippuric acid, Apalutamide, Artesunate, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Favipiravir, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Hydroflumethiazide, Ibuprofen, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Novobiocin, Osilodrostat, Ouabain, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rimegepant, Rosuvastatin, Rucaparib, Salicylic acid, Tafamidis, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Valproic acid, Zidovudine
2	Solute carrier family 22 member 8 inducers	Methyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3	Solute carrier family 22 member 8 substrates	Acamprosate, Acyclovir, Allopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Betamethasone phosphate, Budesonide, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cortisone acetate, Cyclic adenosine monophosphate, Dexamethasone, Dexamethasone acetate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Empagliflozin, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Hydroflumethiazide, Leucovorin, Levocarnitine, Medrysone, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Oxytetracycline, Pemetrexed, Piperacillin, Polythiazide, Pravastatin, Prednisolone phosphate, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Valproic acid, Zidovudine

	Interacting Group	Interacting Drugs
	Indomethacin is a Canalicular multispecific organic anion transporter 1 substrate
1	Canalicular multispecific organic anion transporter 1 inhibitors	5-methyltetrahydrofolic acid, Aminohippuric acid, Azithromycin, Cyclosporine, Daunorubicin, Ethinylestradiol, Etoposide, Furosemide, Fusidic acid, Glutathione, Glyburide, Grepafloxacin, Ivermectin, Letermovir, Lomefloxacin, Lonafarnib, Methotrexate, Norgestimate, Octreotide, Ofloxacin, Pranlukast, Probenecid, Quinidine, Reserpine, Simeprevir, Sorafenib, Sparfloxacin, Sulfinpyrazone, Sunitinib, Telmisartan, Tetrahydrofolic acid, Tricarbonyl(1,10-phenanthroline)rhenium(1+), Vinblastine, Vincristine
2	Canalicular multispecific organic anion transporter 1 substrates	Aminohippuric acid, Atorvastatin, Avibactam, Azithromycin, Belantamab mafodotin, Canagliflozin, Carbamazepine, Carboplatin, Cerivastatin, Conjugated estrogens, Docetaxel, Doxorubicin, Eluxadoline, Erythromycin, Etoposide, Ezetimibe, Fexofenadine, Fluvastatin, Gadoxetic acid, Glutathione, Indinavir, Irinotecan, Lovastatin, Methotrexate, Octreotide, Olmesartan, Oxaliplatin, Paclitaxel, Phenytoin, Pitavastatin, Pralatrexate, Pravastatin, Probenecid, Raloxifene, Ritonavir, Rosuvastatin, Saquinavir, Simeprevir, Simvastatin, Sulfasalazine, Sulfinpyrazone, Talinolol, Tamoxifen, Tenofovir disoproxil, Valsartan, Vasopressin, Vinblastine, Vincristine
3	Canalicular multispecific organic anion transporter 1 inducers	Arsenic trioxide, Cholic Acid, Cisplatin, Dexamethasone, Dexamethasone acetate, Eprosartan, Ethinylestradiol, Hyperforin, Nifedipine, Olmesartan, Phenobarbital, Quercetin, Rifampicin, Spironolactone, Taurocholic acid, Ursodeoxycholic acid, Vinblastine
4	Canalicular multispecific organic anion transporter 1 transporters	Indocyanine green acid form

	Interacting Group	Interacting Drugs
	Indomethacin is a Canalicular multispecific organic anion transporter 1 inhibitor
1	Canalicular multispecific organic anion transporter 1 inhibitors	5-methyltetrahydrofolic acid, Aminohippuric acid, Azithromycin, Cyclosporine, Daunorubicin, Ethinylestradiol, Etoposide, Furosemide, Fusidic acid, Glutathione, Glyburide, Grepafloxacin, Ivermectin, Letermovir, Lomefloxacin, Lonafarnib, Methotrexate, Norgestimate, Octreotide, Ofloxacin, Pranlukast, Probenecid, Quinidine, Reserpine, Simeprevir, Sorafenib, Sparfloxacin, Sulfinpyrazone, Sunitinib, Telmisartan, Tetrahydrofolic acid, Tricarbonyl(1,10-phenanthroline)rhenium(1+), Vinblastine, Vincristine
2	Canalicular multispecific organic anion transporter 1 substrates	Aminohippuric acid, Atorvastatin, Avibactam, Azithromycin, Belantamab mafodotin, Canagliflozin, Carbamazepine, Carboplatin, Cerivastatin, Conjugated estrogens, Docetaxel, Doxorubicin, Eluxadoline, Erythromycin, Etoposide, Ezetimibe, Fexofenadine, Fluvastatin, Gadoxetic acid, Glutathione, Indinavir, Irinotecan, Lovastatin, Methotrexate, Octreotide, Olmesartan, Oxaliplatin, Paclitaxel, Phenytoin, Pitavastatin, Pralatrexate, Pravastatin, Probenecid, Raloxifene, Ritonavir, Rosuvastatin, Saquinavir, Simeprevir, Simvastatin, Sulfasalazine, Sulfinpyrazone, Talinolol, Tamoxifen, Tenofovir disoproxil, Valsartan, Vasopressin, Vinblastine, Vincristine
3	Canalicular multispecific organic anion transporter 1 inducers	Arsenic trioxide, Cholic Acid, Cisplatin, Dexamethasone, Dexamethasone acetate, Eprosartan, Ethinylestradiol, Hyperforin, Nifedipine, Olmesartan, Phenobarbital, Quercetin, Rifampicin, Spironolactone, Taurocholic acid, Ursodeoxycholic acid, Vinblastine
4	Canalicular multispecific organic anion transporter 1 transporters	Indocyanine green acid form

	Interacting Group	Interacting Drugs
	Indomethacin is a ATP-binding cassette sub-family C member 11 inhibitor
1	ATP-binding cassette sub-family C member 11 inhibitors	Cyclic adenosine monophosphate, Probenecid, Taurocholic acid
2	ATP-binding cassette sub-family C member 11 substrates	Conjugated estrogens, Cyclic adenosine monophosphate, Folic acid, Methotrexate

	Interacting Group	Interacting Drugs
	Indomethacin is a Solute carrier family 22 member 11 inhibitor
1	Solute carrier family 22 member 11 inhibitors	Aminohippuric acid, Aspartame, Benzylpenicillin, Bumetanide, Caprylic acid, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Ceftriaxone, Cimetidine, Diclofenac, Dinoprostone, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Furosemide, Glutaric Acid, Ibuprofen, Ketoprofen, Lesinurad, Novobiocin, Oxytetracycline, Phenylbutazone, Piroxicam, Probenecid, Salicylic acid, Tetracycline
2	Solute carrier family 22 member 11 substrates	Aminohippuric acid, Conjugated estrogens, Hydrochlorothiazide, Levocetirizine, Methotrexate, Oxytetracycline, Pravastatin, Relebactam

	Interacting Group	Interacting Drugs
	Indomethacin is a Sodium/bile acid cotransporter substrate
1	Sodium/bile acid cotransporter inhibitors	Bulevirtide, Bumetanide, Cholic Acid, Conjugated estrogens, Cyclosporine, Ethinylestradiol, Probenecid, Progesterone, Remdesivir, Simeprevir, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid
2	Sodium/bile acid cotransporter substrates	Bumetanide, Cholic Acid, Deoxycholic acid, Glycochenodeoxycholic Acid, Liothyronine, Liotrix, Pitavastatin, Taurocholic acid, Thyroid, porcine, Ursodeoxycholic acid

	Interacting Group	Interacting Drugs
	Indomethacin is a Solute carrier family 22 member 7 substrate
1	Solute carrier family 22 member 7 inhibitors	Bumetanide, Cefalotin, Cefamandole, Cefoperazone, Cefotaxime, Cholic Acid, Cimetidine, Clarithromycin, Dinoprostone, Enalapril, Ganciclovir, Glyburide, Ketoprofen, Minocycline, Oxtriphylline, Oxytetracycline, Probenecid, Rifampicin, Testosterone, Tetracycline, Theophylline
2	Solute carrier family 22 member 7 substrates	Allopurinol, Aminohippuric acid, Cimetidine, Cyclic adenosine monophosphate, Dinoprostone, Docetaxel, Fluorouracil, Glutaric Acid, Methotrexate, Oxytetracycline, Pravastatin, Salicylic acid, Tegafur-uracil, Valproic acid, Zalcitabine
3	Solute carrier family 22 member 7 inducers	Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate

	Interacting Group	Interacting Drugs
	Indomethacin is a Solute carrier organic anion transporter family member 1B1 inhibitor
1	Solute carrier organic anion transporter family member 1B1 substrates	Ambrisentan, Asunaprevir, Atorvastatin, Axitinib, Belantamab mafodotin, Benzylpenicillin, Cerivastatin, Cholecystokinin, Cholic Acid, Clotrimazole, Cobimetinib, Conjugated estrogens, Cyclosporine, Digoxin, Dinoprostone, Elagolix, Eluxadoline, Empagliflozin, Erythromycin, Ezetimibe, Fexofenadine, Fimasartan, Fluvastatin, Gadoxetic acid, Gimatecan, Glecaprevir, Grazoprevir, Letermovir, Levomenol, Levosalbutamol, Liothyronine, Liotrix, Lovastatin, Methotrexate, Mycophenolate mofetil, Olmesartan, Ouabain, Paritaprevir, Penicillamine, Pitavastatin, Prasterone, Pravastatin, Raloxifene, Remdesivir, Repaglinide, Revefenacin, Rosuvastatin, Selexipag, Simeprevir, Simvastatin, Sumatriptan, Taurocholic acid, Technetium Tc-99m mebrofenin, Tenofovir alafenamide, Torasemide, Ubrogepant, Valsartan, Voxilaprevir
2	Solute carrier organic anion transporter family member 1B1 inhibitors	Acetylcysteine, Aminohippuric acid, Amprenavir, Artesunate, Asunaprevir, Atazanavir, Atorvastatin, Axitinib, Beclomethasone dipropionate, Bempedoic acid, Benzbromarone, Bezafibrate, Cabazitaxel, Candesartan, Caspofungin, Cerivastatin, Cholecystokinin, Cholic Acid, Clarithromycin, Clotrimazole, Cobicistat, Conjugated estrogens, Cyclosporine, Dabrafenib, Daclatasvir, Darolutamide, Darunavir, Diclofenac, Diethylstilbestrol, Digoxin, Dipyridamole, Dovitinib, Dronedarone, Elexacaftor, Eltrombopag, Eluxadoline, Enasidenib, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Everolimus, Fedratinib, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fostemsavir, Gemfibrozil, Genistein, Glecaprevir, Hyperforin, Idelalisib, Indinavir, Irinotecan, Istradefylline, Ivermectin, Ketoconazole, Lenvatinib, Levocarnitine, Levothyroxine, Lobeglitazone, Lonafarnib, Lopinavir, Lovastatin, Lurbinectedin, Mifepristone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Novobiocin, Nystatin, Opicapone, Osilodrostat, Ouabain, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Pioglitazone, Pitavastatin, Posizolid, Pralsetinib, Progesterone, Quercetin, Quinidine, Quinine, Remdesivir, Reserpine, Rifampicin, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rosiglitazone, Rosuvastatin, Rucaparib, Sacubitril, Saquinavir, Sildenafil, Silibinin, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Sulfasalazine, Tacrolimus, Taurocholic acid, Telaprevir, Telithromycin, Teriflunomide, Tipranavir, Tirbanibulin, Troglitazone, Ubrogepant, Upadacitinib, Valsartan, Valspodar, Velpatasvir, Venetoclax, Verapamil, Vinblastine, Vincristine, Voxilaprevir
3	Solute carrier organic anion transporter family member 1B1 inducers	Apalutamide, Cholic Acid, Taurocholic acid
4	Solute carrier organic anion transporter family member 1B1 weak inhibitors	Cobimetinib
5	Solute carrier organic anion transporter family member 1B1 transporters	Velpatasvir

	Interacting Group	Interacting Drugs
	Indomethacin is a Bile salt export pump substrate
1	Bile salt export pump inhibitors	Amiodarone, Bosentan, Celecoxib, Chlorpromazine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Erythromycin, Ethinylestradiol, Fusidic acid, Glyburide, Glycochenodeoxycholic Acid, Ketoconazole, Lenvatinib, Letermovir, Lopinavir, Nifedipine, Obeticholic acid, Olmesartan, Paclitaxel, Pralsetinib, Progesterone, Quinidine, Remdesivir, Reserpine, Rifampicin, Ritonavir, Simeprevir, Sulfamethoxazole, Tamoxifen, Tipranavir, Troglitazone, Ursodeoxycholic acid, Valinomycin, Vinblastine
2	Bile salt export pump substrates	Amiodarone, Astemizole, Atazanavir, Atenolol, Atorvastatin, Atropine, Belantamab mafodotin, Benzbromarone, Budesonide, Cefaclor, Cerivastatin, Cholic Acid, Clarithromycin, Clotrimazole, Cyclosporine, Daunorubicin, Diclofenac, Diethylstilbestrol, Digoxin, Dihydroergocristine, Dipyridamole, Disulfiram, Doxorubicin, Efavirenz, Erythromycin, Ezetimibe, Felodipine, Fenofibrate, Flucloxacillin, Fluorescein, Fluvoxamine, Glimepiride, Glipizide, Glyburide, Glycochenodeoxycholic Acid, Glycyrrhizic acid, Imatinib, Indinavir, Indocyanine green acid form, Isradipine, Loratadine, Losartan, Lovastatin, Mifepristone, Naproxen, Nefazodone, Nelfinavir, Nicardipine, Nitrendipine, Nitrofurantoin, Ofloxacin, Paclitaxel, Pilsicainide, Pitavastatin, Prasterone sulfate, Pravastatin, Ranolazine, Repaglinide, Rosiglitazone, Rosuvastatin, Saquinavir, Simvastatin, Spironolactone, Sulfinpyrazone, Taurocholic acid, Telmisartan, Terfenadine, Tinidazole, Tipranavir, Ursodeoxycholic acid, Vinblastine, Vincristine
3	Bile salt export pump inducers	Cholic Acid, Deoxycholic acid, Dexamethasone, Dexamethasone acetate, Obeticholic acid, Phenobarbital, Taurocholic acid, Ursodeoxycholic acid