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Identification
NameClobazam
Accession NumberDB00349  (APRD00307)
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionClobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Structure
Thumb
Synonyms
1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
Clobazam
Clobazamum
External Identifiers
  • H 4723
  • HR 376
  • LM 2717
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Clobazam-10tablet10 mgoralPro Doc Limitee2003-12-09Not applicableCanada
Dom-clobazamtablet10 mgoralDominion Pharmacal2003-03-27Not applicableCanada
Frisium Tab 10mgtablet10 mgoralHoechst Canada Inc.1991-12-311996-08-29Canada
Frisium Tablet 10mgtablet10 mgoralLundbeck LLC1997-03-24Not applicableCanada
Frisium Tablets 10mgtablet10 mgoralHoechst Roussel Canada Inc.1994-12-311999-08-11Canada
Novo-clobazamtablet10 mgoralTeva Canada Limited1998-07-07Not applicableCanada
Ntp-clobazamtablet10 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Onfitablet5 mg/1oralLundbeck LLC2011-10-212016-02-28Us
Onfitablet10 mg/1oralLundbeck LLC2013-12-10Not applicableUs
Onfitablet10 mg/1oralLundbeck LLC2013-08-12Not applicableUs
Onfitablet20 mg/1oralLundbeck LLC2013-12-10Not applicableUs
Onfitablet20 mg/1oralLundbeck LLC2013-08-12Not applicableUs
Onfisuspension2.5 mg/mLoralLundbeck LLC2012-12-14Not applicableUs
PMS-clobazamtablet10 mgoralPharmascience Inc2001-11-16Not applicableCanada
Ratio-clobazamtablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited1998-11-302010-08-02Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-clobazam Tabletstablet10 mgoralApotex Inc2001-11-28Not applicableCanada
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AedonSanofi-Aventis
CastiliumSanofi-Aventis
ClobamSquare
ClobamaxSherfarma
FrisiumSanofi-Aventis
GrifoclobamChile
MystanDainippon Sumitomo
NoiafrenSanofi Aventis
SederlonaNot Available
UrbanilSanofi-Aventis
UrbanolSanofi-Aventis
UrbanylSanofi-Aventis
VeniumHudson
Brand mixturesNot Available
SaltsNot Available
Categories
UNII2MRO291B4U
CAS number22316-47-8
WeightAverage: 300.74
Monoisotopic: 300.066555377
Chemical FormulaC16H13ClN2O2
InChI KeyInChIKey=CXOXHMZGEKVPMT-UHFFFAOYSA-N
InChI
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
IUPAC Name
7-chloro-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione
SMILES
CN1C2=C(C=C(Cl)C=C2)N(C2=CC=CC=C2)C(=O)CC1=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub ClassNot Available
Direct ParentBenzodiazepines
Alternative Parents
Substituents
  • Benzodiazepine
  • Chlorobenzene
  • Para-diazepine
  • Benzenoid
  • 1,3-dicarbonyl compound
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Tertiary carboxylic acid amide
  • Tertiary amine
  • Lactam
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
PharmacodynamicsSimilar to other benzodiazepines, clobazam binds to the interface of the α and γ2-subunit of the GABA-A receptor. However, it is considered a partial agonist to GABA-A receptors which sets clobazam apart from 1,4-benzodiazepines which are full agonist. The significance of this difference is that one may experience less sedation with clobazam than with other benzodiazepines. Unlike the endogenous GABA ligand, clobazam binds allosterically to the GABA receptor to increase the frequency of the chloride channel opening and membrane permeability to chloride ions. Pharmacodynamic tolerance has been demonstrated in animal models.
Mechanism of actionClobazam binds at distinct binding sites associated with the chloride ionopore at the post-synaptic GABA receptor. These GABA receptors are in various locations in the CNS (limbic, reticular formation) and clobazam increases the duration of time for which the chloride ionopore is open. As a result, hyper polarization and stabilization of the membrane occur as the post-synaptic inhibitory effect of GABA is enhanced.
Related Articles
AbsorptionAfter oral administration of clobazam, it is almost completely absorbed (87% of dose). Bioavailability relative to solution was almost at 100%. Food does not affect absorption. Tmax = 1-3 hours.
Volume of distribution

Vdss = 100 L. This high volume of distribution suggests extensive distribution to body tissues.

Protein bindingClobazam is the primary circulating entity in the serum and is highly protein-bound (80-90%).
Metabolism

Clobazam is extensively metabolized in the liver via N-demethylation and hydroxylation. Clobazam has two major metabolites: N-desmethylclobazam (norclobazam) and 4'-hydroxyclobazam, the former of which is active. Norclobazam is one-fourth the potency of clobazam. The main enzyme that facilitates the process of N-demethylation is CYP3A4, and to a lesser extent by CYP2C19 and CYP2B6. Norclobazam itself is also metabolized via hydroxylation, primarily by CYP2C19. The formation of 4'-hydroxyclobazam is facilitated by CYP2C18 and CYP2C19. A factor in determining extent of metabolism is the genetic profile of the individual patient as CYP2C19 is a polymorphic enzyme.

SubstrateEnzymesProduct
Clobazam
norclobazamDetails
Clobazam
Not Available
4'-hydroxyclobazamDetails
Route of eliminationClobazam is eliminated via the urine (~94%) as metabolites.
Half lifeThe mean elimination half life of an oral dose of clobazam 40 mg is 32 hours. It's main metabolite, norclobazam, as a half life of 57 hours. The half life in adult patients with epilepsy are higher than those that are healthy.
Clearance

Median estimated clearance = 2.49 L/h

ToxicityThe most common adverse effects include somnolence, pyrexia, upper respiratory tract infection, and lethargy.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261
rs4244285 CYP2C19*2G > A/CClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.15483195
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.99
Blood Brain Barrier+0.9904
Caco-2 permeable+0.7487
P-glycoprotein substrateNon-substrate0.5733
P-glycoprotein inhibitor INon-inhibitor0.5462
P-glycoprotein inhibitor IINon-inhibitor0.9204
Renal organic cation transporterNon-inhibitor0.7373
CYP450 2C9 substrateNon-substrate0.7058
CYP450 2D6 substrateNon-substrate0.8607
CYP450 3A4 substrateSubstrate0.6871
CYP450 1A2 substrateNon-inhibitor0.6829
CYP450 2C9 inhibitorNon-inhibitor0.5296
CYP450 2D6 inhibitorNon-inhibitor0.8908
CYP450 2C19 inhibitorNon-inhibitor0.5791
CYP450 3A4 inhibitorInhibitor0.7008
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5308
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7846
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.7313 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9896
hERG inhibition (predictor II)Non-inhibitor0.8651
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Tabletoral10 mg
Suspensionoral2.5 mg/mL
Tabletoral10 mg/1
Tabletoral20 mg/1
Tabletoral5 mg/1
Prices
Unit descriptionCostUnit
Apo-Clobazam 10 mg Tablet0.23USD tablet
Novo-Clobazam 10 mg Tablet0.23USD tablet
Pms-Clobazam 10 mg Tablet0.23USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point180-182Hauptmann, K.H., Weber, K.-H., Zeile, K., Danneberg, P. and Giesemann, R.; South African Patent 68/0803; February 7,1968; assigned to Boehringer lngelheim GmbH, Germany.
water solubility188 mg/LNot Available
logP2.12HENCZI,M ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.164 mg/mLALOGPS
logP2.14ALOGPS
logP2.55ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)4.07ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area40.62 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity80.3 m3·mol-1ChemAxon
Polarizability30.07 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (11.4 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0pb9-6392000000-a76f30f353b3407df0c6View in MoNA
References
Synthesis Reference

Hauptmann, K.H., Weber, K.-H., Zeile, K., Danneberg, P. and Giesemann, R.; South African
Patent 68/0803; February 7,1968; assigned to Boehringer lngelheim GmbH, Germany.

General References
  1. Freche C: [Study of an anxiolytic, clobazam, in otorhinolaryngology in psychosomatic pharyngeal manifestations]. Sem Hop Ther. 1975 Apr;51(4):261-3. [PubMed:5777 ]
  2. Authors unspecified: Clobazam in treatment of refractory epilepsy: the Canadian experience. A retrospective study. Canadian Clobazam Cooperative Group. Epilepsia. 1991 May-Jun;32(3):407-16. [PubMed:2044502 ]
  3. Wildin JD, Pleuvry BJ, Mawer GE, Onon T, Millington L: Respiratory and sedative effects of clobazam and clonazepam in volunteers. Br J Clin Pharmacol. 1990 Feb;29(2):169-77. [PubMed:2106335 ]
  4. Kilpatrick C, Bury R, Fullinfaw R, Moulds R: Clobazam in the treatment of epilepsy. Clin Exp Neurol. 1987;23:139-44. [PubMed:3117456 ]
  5. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724 ]
  6. Yang LP, Scott LJ: Clobazam : in patients with Lennox-Gastaut syndrome. CNS Drugs. 2012 Nov;26(11):983-91. doi: 10.1007/s40263-012-0007-0. [PubMed:23034582 ]
  7. Walzer M, Bekersky I, Blum RA, Tolbert D: Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy. 2012 Apr;32(4):340-53. doi: 10.1002/j.1875-9114.2012.01028.x. Epub 2012 Mar 15. [PubMed:22422635 ]
External Links
ATC CodesN05BA09
AHFS Codes
  • 28:24.08
PDB EntriesNot Available
FDA labelDownload (595 KB)
MSDSDownload (57.5 KB)
Interactions
Drug Interactions
Drug
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Clobazam.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Clobazam.
AbirateroneThe metabolism of Clobazam can be decreased when combined with Abiraterone.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clobazam.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clobazam.
AcetaminophenThe serum concentration of Clobazam can be increased when it is combined with Acetaminophen.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Clobazam.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Clobazam.
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Clobazam.
AfatinibThe serum concentration of Clobazam can be increased when it is combined with Afatinib.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Clobazam.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Clobazam.
AlbendazoleThe serum concentration of Clobazam can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Clobazam can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Clobazam can be increased when it is combined with Alectinib.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Clobazam.
AlfentanilThe serum concentration of Clobazam can be increased when it is combined with Alfentanil.
AlfentanilThe risk or severity of adverse effects can be increased when Clobazam is combined with Alfentanil.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Clobazam.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Clobazam.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Clobazam.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clobazam.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Clobazam.
AmantadineThe serum concentration of Clobazam can be increased when it is combined with Amantadine.
Aminohippuric acidThe serum concentration of Clobazam can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Clobazam.
AmiodaroneThe serum concentration of Clobazam can be decreased when it is combined with Amiodarone.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Clobazam.
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Clobazam.
AmitriptylineThe serum concentration of Clobazam can be increased when it is combined with Amitriptyline.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Clobazam.
AmlodipineThe serum concentration of Clobazam can be increased when it is combined with Amlodipine.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Clobazam.
AmoxapineThe risk or severity of adverse effects can be increased when Clobazam is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Clobazam.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Clobazam.
AmprenavirThe serum concentration of Clobazam can be decreased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Clobazam.
AmsacrineThe serum concentration of Clobazam can be increased when it is combined with Amsacrine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Clobazam.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Clobazam.
AprepitantThe serum concentration of Clobazam can be increased when it is combined with Aprepitant.
AprindineThe metabolism of Aprindine can be decreased when combined with Clobazam.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Clobazam.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Clobazam.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Clobazam.
ArmodafinilThe metabolism of Clobazam can be decreased when combined with Armodafinil.
ArtemetherThe metabolism of Artemether can be decreased when combined with Clobazam.
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Clobazam.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Clobazam.
AstemizoleThe serum concentration of Clobazam can be increased when it is combined with Astemizole.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Clobazam.
AtazanavirThe serum concentration of Clobazam can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Clobazam can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Clobazam can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Clobazam can be increased when it is combined with Atorvastatin.
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Clobazam.
AzelastineClobazam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe serum concentration of Clobazam can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Clobazam can be increased when it is combined with Azithromycin.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Clobazam.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Clobazam.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Clobazam.
BenzocaineThe serum concentration of Clobazam can be increased when it is combined with Benzocaine.
BenzocaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Benzocaine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Clobazam.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Clobazam.
BepridilThe serum concentration of Clobazam can be increased when it is combined with Bepridil.
BepridilThe metabolism of Bepridil can be decreased when combined with Clobazam.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Clobazam.
BexaroteneThe serum concentration of Clobazam can be decreased when it is combined with Bexarotene.
BiperidenThe serum concentration of Clobazam can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Clobazam.
BoceprevirThe metabolism of Clobazam can be decreased when combined with Boceprevir.
BortezomibThe metabolism of Clobazam can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Clobazam can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Clobazam can be increased when it is combined with Bosutinib.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Clobazam.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Brexpiprazole is combined with Clobazam.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
BrimonidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Clobazam.
BromocriptineThe serum concentration of Clobazam can be increased when it is combined with Bromocriptine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Clobazam.
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Clobazam.
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clobazam.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Clobazam.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Clobazam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clobazam.
BuprenorphineThe serum concentration of Clobazam can be increased when it is combined with Buprenorphine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Clobazam.
BupropionThe metabolism of Bupropion can be decreased when combined with Clobazam.
BuspironeThe serum concentration of Clobazam can be increased when it is combined with Buspirone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Clobazam.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Clobazam.
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Clobazam.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Clobazam.
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Clobazam.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Clobazam.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Clobazam.
CabazitaxelThe serum concentration of Clobazam can be increased when it is combined with Cabazitaxel.
CaffeineThe serum concentration of Clobazam can be increased when it is combined with Caffeine.
CaffeineThe metabolism of Caffeine can be decreased when combined with Clobazam.
CanagliflozinThe serum concentration of Clobazam can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Clobazam can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Clobazam can be increased when it is combined with Captopril.
CaptoprilThe metabolism of Captopril can be decreased when combined with Clobazam.
CarbamazepineThe serum concentration of Clobazam can be decreased when it is combined with Carbamazepine.
CarbamazepineThe risk or severity of adverse effects can be increased when Clobazam is combined with Carbamazepine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clobazam.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Clobazam.
CarisoprodolThe risk or severity of adverse effects can be increased when Clobazam is combined with Carisoprodol.
CarteololThe metabolism of Carteolol can be decreased when combined with Clobazam.
CarvedilolThe serum concentration of Clobazam can be increased when it is combined with Carvedilol.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Clobazam.
CaspofunginThe serum concentration of Clobazam can be increased when it is combined with Caspofungin.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Clobazam.
CeritinibThe serum concentration of Clobazam can be increased when it is combined with Ceritinib.
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Clobazam.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Clobazam.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clobazam.
ChloramphenicolThe metabolism of Clobazam can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Clobazam.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clobazam.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clobazam.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Clobazam.
ChloroquineThe serum concentration of Clobazam can be increased when it is combined with Chloroquine.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Clobazam.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Clobazam.
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Clobazam.
ChlorpromazineThe serum concentration of Clobazam can be increased when it is combined with Chlorpromazine.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Clobazam.
ChlorpropamideThe serum concentration of Clobazam can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Clobazam can be increased when it is combined with Chlorprothixene.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Clobazam is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Clobazam.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Clobazam.
CholecalciferolThe metabolism of Clobazam can be decreased when combined with Cholecalciferol.
CholesterolThe serum concentration of Clobazam can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Clobazam can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Clobazam can be increased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Clobazam.
CimetidineThe serum concentration of Clobazam can be decreased when it is combined with Cimetidine.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Clobazam.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Clobazam.
CiprofloxacinThe serum concentration of Clobazam can be increased when it is combined with Ciprofloxacin.
CitalopramThe risk or severity of adverse effects can be increased when Clobazam is combined with Citalopram.
CitalopramThe serum concentration of Clobazam can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Clobazam can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Clobazam can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Clobazam is combined with Clemastine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Clobazam.
ClidiniumThe risk or severity of adverse effects can be increased when Clobazam is combined with Clidinium.
ClofazimineThe serum concentration of Clobazam can be increased when it is combined with Clofazimine.
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clobazam.
ClomipramineThe risk or severity of adverse effects can be increased when Clobazam is combined with Clomipramine.
ClomipramineThe serum concentration of Clobazam can be increased when it is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Clonazepam.
ClonidineThe metabolism of Clonidine can be decreased when combined with Clobazam.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Clobazam.
ClopidogrelThe metabolism of Clobazam can be decreased when combined with Clopidogrel.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Clobazam.
ClotrimazoleThe metabolism of Clobazam can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Clobazam.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Clobazam.
CobicistatThe serum concentration of Clobazam can be increased when it is combined with Cobicistat.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Clobazam.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Clobazam.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Clobazam.
ColchicineThe serum concentration of Clobazam can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Clobazam can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Clobazam can be increased when it is combined with Conivaptan.
CrizotinibThe metabolism of Clobazam can be decreased when combined with Crizotinib.
CyclizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cyclizine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Clobazam.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Clobazam.
CyclophosphamideThe serum concentration of Clobazam can be increased when it is combined with Cyclophosphamide.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Clobazam.
CyclosporineThe metabolism of Clobazam can be decreased when combined with Cyclosporine.
CyproheptadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cyproheptadine.
DabrafenibThe serum concentration of Clobazam can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Clobazam can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Clobazam can be increased when it is combined with Dactinomycin.
DantroleneThe risk or severity of adverse effects can be increased when Clobazam is combined with Dantrolene.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Clobazam.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Clobazam.
DapoxetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dapoxetine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Clobazam.
DarunavirThe metabolism of Clobazam can be decreased when combined with Darunavir.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Clobazam.
DasatinibThe serum concentration of Clobazam can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Clobazam can be decreased when it is combined with Daunorubicin.
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Clobazam.
DeferasiroxThe serum concentration of Clobazam can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Clobazam can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Clobazam.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Clobazam.
DesipramineThe serum concentration of Clobazam can be increased when it is combined with Desipramine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Clobazam.
DesloratadineThe serum concentration of Clobazam can be increased when it is combined with Desloratadine.
DesloratadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Clobazam.
DexamethasoneThe serum concentration of Clobazam can be decreased when it is combined with Dexamethasone.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dexbrompheniramine.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Clobazam.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Clobazam.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Clobazam.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Clobazam.
DextromethorphanThe serum concentration of Clobazam can be increased when it is combined with Dextromethorphan.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Clobazam.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Clobazam.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Clobazam.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clobazam.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Clobazam.
DiclofenacThe serum concentration of Clobazam can be increased when it is combined with Diclofenac.
DifenoxinThe risk or severity of adverse effects can be increased when Clobazam is combined with Difenoxin.
DigoxinThe serum concentration of Clobazam can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Clobazam.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Clobazam.
DihydroergotamineThe metabolism of Clobazam can be decreased when combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Clobazam.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Clobazam.
DiltiazemThe metabolism of Clobazam can be decreased when combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Clobazam is combined with Dimenhydrinate.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Clobazam.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Clobazam.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Clobazam.
DipyridamoleThe serum concentration of Clobazam can be increased when it is combined with Dipyridamole.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Clobazam.
DomperidoneThe metabolism of Domperidone can be decreased when combined with Clobazam.
DonepezilThe metabolism of Donepezil can be decreased when combined with Clobazam.
DopamineThe metabolism of Dopamine can be decreased when combined with Clobazam.
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Clobazam.
DoxazosinThe serum concentration of Clobazam can be increased when it is combined with Doxazosin.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Clobazam.
DoxepinThe serum concentration of Clobazam can be increased when it is combined with Doxepin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Clobazam.
DoxorubicinThe serum concentration of Clobazam can be decreased when it is combined with Doxorubicin.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Clobazam.
DoxycyclineThe metabolism of Clobazam can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
DoxylamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Clobazam.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
DronedaroneThe metabolism of Clobazam can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Clobazam.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Clobazam.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Clobazam.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Clobazam.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Clobazam.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Clobazam.
EfavirenzThe serum concentration of Clobazam can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Clobazam is combined with Efavirenz.
ElbasvirThe serum concentration of Clobazam can be increased when it is combined with Elbasvir.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Clobazam.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Clobazam.
EnalaprilThe serum concentration of Clobazam can be increased when it is combined with Enalapril.
EncainideThe metabolism of Encainide can be decreased when combined with Clobazam.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Clobazam.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Clobazam.
EntacaponeThe risk or severity of adverse effects can be increased when Clobazam is combined with Entacapone.
EnzalutamideThe serum concentration of Clobazam can be increased when it is combined with Enzalutamide.
EpinastineThe metabolism of Epinastine can be decreased when combined with Clobazam.
ErgonovineThe serum concentration of Clobazam can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Clobazam can be increased when it is combined with Ergotamine.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Clobazam.
ErythromycinThe metabolism of Clobazam can be decreased when combined with Erythromycin.
EscitalopramThe risk or severity of adverse effects can be increased when Clobazam is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Clobazam can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Clobazam.
EsomeprazoleThe metabolism of Clobazam can be decreased when combined with Esomeprazole.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Clobazam.
EstramustineThe serum concentration of Clobazam can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Clobazam can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Clobazam can be decreased when it is combined with Estrone.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Clobazam.
EthanolClobazam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Clobazam.
EthosuximideThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Clobazam.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Clobazam.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Clobazam.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Clobazam.
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Clobazam.
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clobazam.
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Clobazam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Clobazam.
EtoperidoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Etoperidone.
EtoposideThe serum concentration of Clobazam can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Clobazam.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Clobazam.
EtravirineThe serum concentration of Clobazam can be decreased when it is combined with Etravirine.
EzogabineThe risk or severity of adverse effects can be increased when Clobazam is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Clobazam is combined with Felbamate.
FelodipineThe serum concentration of Clobazam can be increased when it is combined with Felodipine.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Clobazam.
FenfluramineThe risk or severity of adverse effects can be increased when Clobazam is combined with Fenfluramine.
FentanylThe serum concentration of Clobazam can be increased when it is combined with Fentanyl.
FentanylThe risk or severity of adverse effects can be increased when Clobazam is combined with Fentanyl.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Clobazam.
FexofenadineThe serum concentration of Clobazam can be increased when it is combined with Fexofenadine.
FexofenadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Fexofenadine.
FidaxomicinThe serum concentration of Clobazam can be increased when it is combined with Fidaxomicin.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Clobazam.
FlecainideThe metabolism of Flecainide can be decreased when combined with Clobazam.
FlibanserinThe risk or severity of adverse effects can be increased when Clobazam is combined with Flibanserin.
FluconazoleThe metabolism of Clobazam can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Clobazam.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Clobazam.
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Clobazam.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Clobazam.
FluoxetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluoxetine.
FluoxetineThe serum concentration of Clobazam can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Clobazam can be increased when it is combined with Flupentixol.
FlupentixolThe risk or severity of adverse effects can be increased when Clobazam is combined with Flupentixol.
FluphenazineThe serum concentration of Clobazam can be increased when it is combined with Fluphenazine.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Clobazam.
FlurazepamThe serum concentration of Clobazam can be increased when it is combined with Flurazepam.
FlurazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Clobazam.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluticasone Propionate.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Clobazam.
FluvoxamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluvoxamine.
FluvoxamineThe metabolism of Clobazam can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Clobazam.
FosamprenavirThe metabolism of Clobazam can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Clobazam can be increased when it is combined with Fosaprepitant.
FosphenytoinThe risk or severity of adverse effects can be increased when Clobazam is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Clobazam.
Fusidic AcidThe serum concentration of Clobazam can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Clobazam.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Clobazam is combined with gabapentin enacarbil.
GalantamineThe metabolism of Galantamine can be decreased when combined with Clobazam.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Clobazam.
GefitinibThe serum concentration of Clobazam can be increased when it is combined with Gefitinib.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Clobazam.
GemfibrozilThe metabolism of Clobazam can be decreased when combined with Gemfibrozil.
GenisteinThe serum concentration of Clobazam can be increased when it is combined with Genistein.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clobazam.
GlyburideThe serum concentration of Clobazam can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Clobazam can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Clobazam can be increased when it is combined with Gramicidin D.
GranisetronThe metabolism of Granisetron can be decreased when combined with Clobazam.
GrepafloxacinThe serum concentration of Clobazam can be increased when it is combined with Grepafloxacin.
GuanfacineThe risk or severity of adverse effects can be increased when Clobazam is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Clobazam.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Clobazam.
HaloperidolThe serum concentration of Clobazam can be increased when it is combined with Haloperidol.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Clobazam.
HalothaneThe metabolism of Halothane can be decreased when combined with Clobazam.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Clobazam.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Clobazam.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Clobazam.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Clobazam.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Clobazam.
HydrocortisoneThe serum concentration of Clobazam can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Clobazam.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Clobazam.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
HydroxyzineThe risk or severity of adverse effects can be increased when Clobazam is combined with Hydroxyzine.
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Clobazam.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Clobazam.
IdelalisibThe serum concentration of Clobazam can be increased when it is combined with Idelalisib.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Clobazam.
IloperidoneThe risk or severity of adverse effects can be increased when Iloperidone is combined with Clobazam.
ImatinibThe metabolism of Clobazam can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Clobazam can be increased when it is combined with Imipramine.
ImipramineThe metabolism of Imipramine can be decreased when combined with Clobazam.
IndalpineThe risk or severity of adverse effects can be increased when Clobazam is combined with Indalpine.
IndinavirThe serum concentration of Clobazam can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Clobazam can be increased when it is combined with Indomethacin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Clobazam.
IsavuconazoniumThe metabolism of Clobazam can be decreased when combined with Isavuconazonium.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Clobazam.
IsoniazidThe metabolism of Clobazam can be decreased when combined with Isoniazid.
IsradipineThe metabolism of Clobazam can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Clobazam can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Clobazam can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Clobazam can be increased when it is combined with Ivermectin.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Clobazam.
KetamineThe serum concentration of Clobazam can be increased when it is combined with Ketamine.
KetamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Clobazam.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Clobazam.
KetoconazoleThe serum concentration of Clobazam can be increased when it is combined with Ketoconazole.
LabetalolThe metabolism of Labetalol can be decreased when combined with Clobazam.
LamotrigineThe risk or severity of adverse effects can be increased when Clobazam is combined with Lamotrigine.
LansoprazoleThe serum concentration of Clobazam can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Clobazam can be increased when it is combined with Lapatinib.
LevetiracetamThe risk or severity of adverse effects can be increased when Clobazam is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Clobazam.
LevocabastineThe risk or severity of adverse effects can be increased when Clobazam is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Levocetirizine.
LevodopaThe metabolism of Levodopa can be decreased when combined with Clobazam.
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Clobazam.
LevofloxacinThe serum concentration of Clobazam can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Clobazam.
LevomilnacipranThe risk or severity of adverse effects can be increased when Clobazam is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Clobazam.
LevothyroxineThe serum concentration of Clobazam can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Clobazam can be increased when it is combined with Lidocaine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Clobazam.
LiothyronineThe serum concentration of Clobazam can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Clobazam can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Clobazam can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Clobazam.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Clobazam.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Clobazam.
LomitapideThe serum concentration of Clobazam can be increased when it is combined with Lomitapide.
LomustineThe metabolism of Lomustine can be decreased when combined with Clobazam.
LoperamideThe serum concentration of Clobazam can be increased when it is combined with Loperamide.
LoperamideThe metabolism of Loperamide can be decreased when combined with Clobazam.
LopinavirThe serum concentration of Clobazam can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Clobazam can be increased when it is combined with Loratadine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Clobazam.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clobazam.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Clobazam.
LosartanThe serum concentration of Clobazam can be increased when it is combined with Losartan.
LovastatinThe metabolism of Clobazam can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Clobazam.
Lu AA21004The risk or severity of adverse effects can be increased when Clobazam is combined with Lu AA21004.
LuliconazoleThe serum concentration of Clobazam can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Clobazam can be decreased when it is combined with Lumacaftor.
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Clobazam.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Clobazam is combined with Magnesium Sulfate.
MaprotilineThe serum concentration of Clobazam can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Clobazam.
MebendazoleThe serum concentration of Clobazam can be increased when it is combined with Mebendazole.
MeclizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Clobazam.
MefloquineThe serum concentration of Clobazam can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Clobazam can be increased when it is combined with Megestrol acetate.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Clobazam.
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Clobazam.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Clobazam.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Clobazam.
MeprobamateThe serum concentration of Clobazam can be increased when it is combined with Meprobamate.
MeprobamateThe risk or severity of adverse effects can be increased when Clobazam is combined with Meprobamate.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Clobazam.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Clobazam.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Clobazam.
MetaxaloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Metaxalone.
MethadoneThe serum concentration of Clobazam can be increased when it is combined with Methadone.
MethadoneThe metabolism of Methadone can be decreased when combined with Clobazam.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clobazam.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Clobazam.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Clobazam.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Clobazam.
MethocarbamolThe risk or severity of adverse effects can be increased when Clobazam is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Clobazam.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Clobazam.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Clobazam.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Clobazam.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Clobazam.
MethsuximideThe risk or severity of adverse effects can be increased when Clobazam is combined with Methsuximide.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Clobazam.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Clobazam.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Clobazam.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Clobazam.
MetoprololThe serum concentration of Clobazam can be increased when it is combined with Metoprolol.
MetoprololThe metabolism of Metoprolol can be decreased when combined with Clobazam.
MetyrosineClobazam may increase the sedative activities of Metyrosine.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Clobazam.
MianserinThe therapeutic efficacy of Clobazam can be decreased when used in combination with Mianserin.
MianserinThe metabolism of Mianserin can be decreased when combined with Clobazam.
MibefradilThe serum concentration of Clobazam can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Clobazam can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Clobazam can be decreased when it is combined with Midazolam.
MidazolamThe risk or severity of adverse effects can be increased when Clobazam is combined with Midazolam.
MifepristoneThe metabolism of Clobazam can be decreased when combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Clobazam is combined with Milnacipran.
MinaprineThe metabolism of Minaprine can be decreased when combined with Clobazam.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Clobazam.
MirtazapineClobazam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Clobazam.
MitomycinThe serum concentration of Clobazam can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Clobazam can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Clobazam can be decreased when it is combined with Mitoxantrone.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Clobazam.
ModafinilThe serum concentration of Clobazam can be decreased when it is combined with Modafinil.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Clobazam.
MorphineThe serum concentration of Clobazam can be increased when it is combined with Morphine.
MorphineThe metabolism of Morphine can be decreased when combined with Clobazam.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
NabiloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Nabilone.
NafcillinThe serum concentration of Clobazam can be decreased when it is combined with Nafcillin.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Clobazam.
NaltrexoneThe serum concentration of Clobazam can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Clobazam can be increased when it is combined with Naringenin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Clobazam.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Clobazam.
NefazodoneThe serum concentration of Clobazam can be decreased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Clobazam.
NelfinavirThe serum concentration of Clobazam can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Clobazam can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Clobazam can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Clobazam.
NevirapineThe metabolism of Clobazam can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Clobazam can be increased when it is combined with Nicardipine.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Clobazam.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Clobazam.
NicotineThe metabolism of Nicotine can be decreased when combined with Clobazam.
NifedipineThe serum concentration of Clobazam can be decreased when it is combined with Nifedipine.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Clobazam.
NilotinibThe metabolism of Clobazam can be decreased when combined with Nilotinib.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Clobazam.
NisoldipineThe serum concentration of Clobazam can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Clobazam can be increased when it is combined with Nitrazepam.
NitrazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Nitrazepam.
NitrendipineThe serum concentration of Clobazam can be increased when it is combined with Nitrendipine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Clobazam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clobazam.
NorethisteroneThe serum concentration of Clobazam can be decreased when it is combined with Norethisterone.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Clobazam.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Clobazam.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Clobazam.
OlanzapineThe risk or severity of adverse effects can be increased when Clobazam is combined with Olanzapine.
OlaparibThe metabolism of Clobazam can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Olopatadine.
OmeprazoleThe serum concentration of Clobazam can be increased when it is combined with Omeprazole.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Clobazam.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Clobazam.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Clobazam.
OrlistatThe serum concentration of Clobazam can be decreased when it is combined with Orlistat.
OrphenadrineClobazam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Clobazam.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Clobazam.
OsimertinibThe serum concentration of Clobazam can be increased when it is combined with Osimertinib.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Clobazam.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Clobazam.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Clobazam.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Clobazam.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clobazam.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Clobazam.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Clobazam.
P-NitrophenolThe serum concentration of Clobazam can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Clobazam can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Clobazam can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Clobazam.
Palmitic AcidThe serum concentration of Clobazam can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Clobazam.
PantoprazoleThe serum concentration of Clobazam can be increased when it is combined with Pantoprazole.
ParaldehydeClobazam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Clobazam.
ParoxetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Paroxetine.
ParoxetineThe serum concentration of Clobazam can be increased when it is combined with Paroxetine.
PazopanibThe metabolism of Pazopanib can be decreased when combined with Clobazam.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Clobazam.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Clobazam.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Clobazam.
PerampanelThe risk or severity of adverse effects can be increased when Clobazam is combined with Perampanel.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Clobazam.
PerindoprilThe serum concentration of Clobazam can be increased when it is combined with Perindopril.
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Clobazam.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Clobazam.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Clobazam.
PethidineThe metabolism of Pethidine can be decreased when combined with Clobazam.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Clobazam.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Clobazam.
PhenforminThe metabolism of Phenformin can be decreased when combined with Clobazam.
PhenobarbitalThe serum concentration of Clobazam can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe risk or severity of adverse effects can be increased when Clobazam is combined with Phenobarbital.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Clobazam.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Clobazam.
PimozideThe serum concentration of Clobazam can be increased when it is combined with Pimozide.
PimozideThe risk or severity of adverse effects can be increased when Clobazam is combined with Pimozide.
PindololThe metabolism of Pindolol can be decreased when combined with Clobazam.
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Clobazam.
PiperazineThe metabolism of Piperazine can be decreased when combined with Clobazam.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Clobazam.
PipotiazineThe risk or severity of adverse effects can be increased when Pipotiazine is combined with Clobazam.
PizotifenThe risk or severity of adverse effects can be increased when Clobazam is combined with Pizotifen.
Platelet Activating FactorThe serum concentration of Clobazam can be decreased when it is combined with Platelet Activating Factor.
PomalidomideThe risk or severity of adverse effects can be increased when Clobazam is combined with Pomalidomide.
PonatinibThe serum concentration of Clobazam can be increased when it is combined with Ponatinib.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Clobazam.
PosaconazoleThe serum concentration of Clobazam can be increased when it is combined with Posaconazole.
PramipexoleClobazam may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Clobazam.
PravastatinThe serum concentration of Clobazam can be increased when it is combined with Pravastatin.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Clobazam.
PrazosinThe serum concentration of Clobazam can be increased when it is combined with Prazosin.
PrednisoneThe serum concentration of Clobazam can be increased when it is combined with Prednisone.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clobazam.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clobazam.
PrimidoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Primidone.
ProbenecidThe serum concentration of Clobazam can be increased when it is combined with Probenecid.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Clobazam.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Clobazam.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Clobazam.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Clobazam.
ProgesteroneThe serum concentration of Clobazam can be decreased when it is combined with Progesterone.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Clobazam.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Clobazam.
PromethazineThe serum concentration of Clobazam can be increased when it is combined with Promethazine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Clobazam.
PropafenoneThe serum concentration of Clobazam can be increased when it is combined with Propafenone.
PropafenoneThe metabolism of Propafenone can be decreased when combined with Clobazam.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clobazam.
PropofolThe metabolism of Propofol can be decreased when combined with Clobazam.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Clobazam.
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Clobazam.
PropranololThe serum concentration of Clobazam can be increased when it is combined with Propranolol.
PropranololThe metabolism of Propranolol can be decreased when combined with Clobazam.
ProtriptylineThe serum concentration of Clobazam can be increased when it is combined with Protriptyline.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Clobazam.
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Clobazam.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Clobazam.
QuazepamThe serum concentration of Clobazam can be increased when it is combined with Quazepam.
QuazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Quazepam.
QuercetinThe serum concentration of Clobazam can be increased when it is combined with Quercetin.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Clobazam.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Clobazam.
QuinacrineThe serum concentration of Clobazam can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Clobazam can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Clobazam can be increased when it is combined with Quinine.
QuinineThe metabolism of Quinine can be decreased when combined with Clobazam.
RamelteonThe risk or severity of adverse effects can be increased when Clobazam is combined with Ramelteon.
RanitidineThe serum concentration of Clobazam can be increased when it is combined with Ranitidine.
RanitidineThe metabolism of Ranitidine can be decreased when combined with Clobazam.
RanolazineThe serum concentration of Clobazam can be increased when it is combined with Ranolazine.
ReboxetineThe serum concentration of Clobazam can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Clobazam can be increased when it is combined with Regorafenib.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Clobazam.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Clobazam.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Clobazam.
repinotanThe metabolism of repinotan can be decreased when combined with Clobazam.
ReserpineThe serum concentration of Clobazam can be decreased when it is combined with Reserpine.
ReserpineThe risk or severity of adverse effects can be increased when Clobazam is combined with Reserpine.
RifabutinThe metabolism of Clobazam can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Clobazam can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Clobazam can be increased when combined with Rifapentine.
RilpivirineThe serum concentration of Clobazam can be increased when it is combined with Rilpivirine.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Clobazam.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Clobazam.
RitonavirThe serum concentration of Clobazam can be decreased when it is combined with Ritonavir.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Clobazam.
RolapitantThe serum concentration of Clobazam can be increased when it is combined with Rolapitant.
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Clobazam.
RopiniroleClobazam may increase the sedative activities of Ropinirole.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Clobazam.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Clobazam.
RotigotineClobazam may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Clobazam.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Clobazam.
SaquinavirThe serum concentration of Clobazam can be decreased when it is combined with Saquinavir.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Clobazam.
ScopolamineThe serum concentration of Clobazam can be increased when it is combined with Scopolamine.
ScopolamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Clobazam.
SelegilineThe serum concentration of Clobazam can be increased when it is combined with Selegiline.
SertindoleThe metabolism of Sertindole can be decreased when combined with Clobazam.
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Clobazam.
SertralineThe risk or severity of adverse effects can be increased when Clobazam is combined with Sertraline.
SertralineThe serum concentration of Clobazam can be increased when it is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Clobazam.
SildenafilThe metabolism of Clobazam can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Clobazam can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Clobazam can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Clobazam can be increased when it is combined with Simvastatin.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Clobazam.
SirolimusThe serum concentration of Clobazam can be decreased when it is combined with Sirolimus.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Clobazam.
SorafenibThe serum concentration of Clobazam can be increased when it is combined with Sorafenib.
SparteineThe metabolism of Sparteine can be decreased when combined with Clobazam.
SpironolactoneThe serum concentration of Clobazam can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Clobazam can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Clobazam can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Stiripentol can be increased when it is combined with Clobazam.
StiripentolThe risk or severity of adverse effects can be increased when Stiripentol is combined with Clobazam.
StreptozocinThe serum concentration of Clobazam can be decreased when it is combined with Streptozocin.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Clobazam.
SulfinpyrazoneThe serum concentration of Clobazam can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Clobazam can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Clobazam.
SumatriptanThe serum concentration of Clobazam can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Clobazam can be increased when it is combined with Sunitinib.
SuvorexantThe risk or severity of adverse effects can be increased when Clobazam is combined with Suvorexant.
TacrineThe serum concentration of Clobazam can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Clobazam can be decreased when it is combined with Tacrolimus.
TamoxifenThe serum concentration of Clobazam can be decreased when it is combined with Tamoxifen.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Clobazam.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Clobazam.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Clobazam.
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Clobazam.
TasimelteonThe risk or severity of adverse effects can be increased when Clobazam is combined with Tasimelteon.
Taurocholic AcidThe serum concentration of Clobazam can be increased when it is combined with Taurocholic Acid.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Clobazam.
TelaprevirThe metabolism of Clobazam can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Clobazam can be decreased when combined with Telithromycin.
TelmisartanThe serum concentration of Clobazam can be increased when it is combined with Telmisartan.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Clobazam.
TemsirolimusThe serum concentration of Clobazam can be increased when it is combined with Temsirolimus.
TerazosinThe serum concentration of Clobazam can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Clobazam can be increased when it is combined with Terfenadine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Clobazam.
TesmilifeneThe serum concentration of Clobazam can be decreased when it is combined with Tesmilifene.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Clobazam.
TestosteroneThe serum concentration of Clobazam can be increased when it is combined with Testosterone.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Clobazam.
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Clobazam.
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Clobazam.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Clobazam.
ThalidomideClobazam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Clobazam.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Clobazam.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Clobazam.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Clobazam.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Clobazam.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Clobazam.
ThiotepaThe metabolism of Clobazam can be decreased when combined with Thiotepa.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Clobazam.
TiagabineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tiagabine.
TicagrelorThe serum concentration of Clobazam can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Clobazam can be decreased when combined with Ticlopidine.
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Clobazam.
TimololThe metabolism of Timolol can be decreased when combined with Clobazam.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Clobazam.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Clobazam.
TizanidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tizanidine.
TocilizumabThe serum concentration of Clobazam can be decreased when it is combined with Tocilizumab.
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Clobazam.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Clobazam.
TolvaptanThe serum concentration of Clobazam can be increased when it is combined with Tolvaptan.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Clobazam.
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Clobazam.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Clobazam.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Clobazam.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Clobazam.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Clobazam.
TrazodoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Trazodone.
TrazodoneThe serum concentration of Clobazam can be decreased when it is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Clobazam.
TrifluoperazineThe serum concentration of Clobazam can be increased when it is combined with Trifluoperazine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Clobazam can be increased when it is combined with Triflupromazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Triflupromazine.
TrimethoprimThe serum concentration of Clobazam can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Clobazam can be increased when it is combined with Trimipramine.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Clobazam.
TriprolidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Triprolidine.
TroleandomycinThe serum concentration of Clobazam can be increased when it is combined with Troleandomycin.
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Clobazam.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Clobazam.
VenlafaxineThe metabolism of Clobazam can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Clobazam can be decreased when combined with Verapamil.
VigabatrinThe risk or severity of adverse effects can be increased when Clobazam is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Vilazodone.
VinblastineThe serum concentration of Clobazam can be decreased when it is combined with Vinblastine.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Clobazam.
VincristineThe serum concentration of Clobazam can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Clobazam can be increased when it is combined with Vinorelbine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Clobazam.
VoriconazoleThe metabolism of Clobazam can be decreased when combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Clobazam.
YohimbineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Yohimbine.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Clobazam.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Clobazam.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Clobazam.
ZiconotideThe risk or severity of adverse effects can be increased when Clobazam is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Zimelidine.
ZimelidineThe serum concentration of Clobazam can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Clobazam can be decreased when combined with Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Clobazam.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Clobazam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Clobazam.
ZonisamideThe risk or severity of adverse effects can be increased when Clobazam is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Clobazam.
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Clobazam.
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Clobazam.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Clobazam.
Food Interactions
  • Alcohol increases clobazam absorption by 50%.
  • Take without regard to meals.

Targets

Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular Weight:
55710.075 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
Other
General Function:
Neurotransmitter:sodium symporter activity
Specific Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A1
Uniprot ID:
P30531
Molecular Weight:
67073.0 Da
References
  1. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
Other
General Function:
Neurotransmitter:sodium symporter activity
Specific Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A11
Uniprot ID:
P48066
Molecular Weight:
70605.145 Da
References
  1. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23