Showing BioInteractions for Pramipexole (DB00413)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 5
Transporter Mediated Interactions 2

	Interacting Group	Interacting Drugs
	Pramipexole is a Dopamine D3 receptor agonist
1	Dopamine D3 receptor antagonists	Amisulpride, Amoxapine, Aripiprazole, AS-8112, Asenapine, Blonanserin, Buspirone, Chlorprothixene, Clozapine, Domperidone, Flupentixol, Iloperidone, Methotrimeprazine, Olanzapine, Paliperidone, Pimozide, Remoxipride, Sulpiride, Yohimbine, Ziprasidone
2	Dopamine D3 receptor agonists	Apomorphine, Bromocriptine, Cabergoline, Captodiame, Cariprazine, Dopamine, Levodopa, Lisuride, Pergolide, Ropinirole, Rotigotine, Tianeptine
3	Dopamine D3 receptor partial agonists	Aripiprazole, Cariprazine, Dihydro-alpha-ergocryptine
4	Dopamine D3 receptor inverse agonists	Haloperidol
5	Dopamine D3 receptor ligands	Quetiapine, Sarizotan
6	Dopamine D3 receptor inhibitors	Chlorpromazine
7	Dopamine D3 receptor binders	Loxapine, Mianserin
8	Dopamine D3 receptor blockers	Tiapride

	Interacting Group	Interacting Drugs
	Pramipexole is a Dopamine D4 receptor agonist
1	Dopamine D4 receptor antagonists	Amoxapine, Aripiprazole, Asenapine, Bromocriptine, Buspirone, Clozapine, Flibanserin, Flupentixol, Iloperidone, Methotrimeprazine, Olanzapine, Paliperidone, Perospirone, Pipamperone, Remoxipride, Sulpiride, Ziprasidone
2	Dopamine D4 receptor agonists	Apomorphine, Cabergoline, Dopamine, Flibanserin, Levodopa, Lisuride, Pergolide, Ropinirole, Rotigotine
3	Dopamine D4 receptor partial agonists	Aripiprazole
4	Dopamine D4 receptor ligands	Quetiapine
5	Dopamine D4 receptor binders	Chlorpromazine, Loxapine

	Interacting Group	Interacting Drugs
	Pramipexole is a Dopamine D2 receptor agonist
1	Dopamine D2 receptor agonists	Amantadine, Apomorphine, Brexpiprazole, Bromocriptine, Cabergoline, Cariprazine, Dihydro-alpha-ergocryptine, Dopamine, Ergotamine, Ketamine, Lamotrigine, Levodopa, Lisuride, Memantine, Minaprine, Pergolide, Quinagolide, Ropinirole, Rotigotine
2	Dopamine D2 receptor antagonists	Acepromazine, Acetophenazine, Alizapride, Amisulpride, Amoxapine, Aripiprazole, AS-8112, Asenapine, Blonanserin, Bromopride, Buspirone, Carphenazine, Chlorpromazine, Chlorprothixene, Clozapine, Domperidone, Droperidol, Etoperidone, Flupentixol, Fluphenazine, Fluspirilene, Haloperidol, Iloperidone, JNJ-37822681, Loxapine, Lurasidone, Melperone, Memantine, Mesoridazine, Methotrimeprazine, Metoclopramide, Mianserin, Molindone, Nortriptyline, Olanzapine, Paliperidone, Perospirone, Perphenazine, Pimozide, Pipamperone, Pipotiazine, Prochlorperazine, Promazine, Promethazine, Propiomazine, Quetiapine, Raclopride, Remoxipride, Risperidone, Sertindole, Sulpiride, Tetrahydropalmatine, Thiethylperazine, Thioproperazine, Thioridazine, Thiothixene, Trifluoperazine, Triflupromazine, YKP-1358, Yohimbine, Ziprasidone, Zotepine, Zuclopenthixol
3	Dopamine D2 receptor partial agonists	Aripiprazole, Aripiprazole lauroxil, Brexpiprazole, Cariprazine, Ketamine, Lumateperone, Sarizotan
4	Dopamine D2 receptor inhibitors	Escitalopram, Lamotrigine, Tetrabenazine
5	Dopamine D2 receptor binders	Amphetamine, Desipramine, Imipramine, Maprotiline
6	Dopamine D2 receptor blockers	Tiapride

	Interacting Group	Interacting Drugs
	Pramipexole is a 5-hydroxytryptamine receptor 1A agonist
1	5-hydroxytryptamine receptor 1A partial agonists	Aripiprazole, Aripiprazole lauroxil, Brexpiprazole, Buspirone, Cariprazine, Perospirone, Quetiapine, Trazodone, Yohimbine
2	5-hydroxytryptamine receptor 1A agonists	5-methoxy-N,N-dimethyltryptamine, Apomorphine, Brexpiprazole, Bromocriptine, Cabergoline, Cannabidiol, Cariprazine, Cinitapride, Eletriptan, Ergotamine, Fenfluramine, Flibanserin, Lisuride, Lofexidine, Methysergide, Naluzotan, Naratriptan, Oxymetazoline, Pergolide, Rotigotine, SEP-363856, Sumatriptan, Tetrahydrocannabivarin, Vilazodone, Vortioxetine, Ziprasidone, Zolmitriptan
3	5-hydroxytryptamine receptor 1A antagonists	Acepromazine, Alprenolol, Alverine, Amoxapine, Asenapine, Chlorpromazine, Clozapine, Dosulepin, Doxepin, Iloperidone, Lurasidone, Molindone, Nefazodone, Nortriptyline, Paliperidone, Penbutolol, Pindolol, Pipotiazine, Pirlindole, Pizotifen, Quetiapine, Risperidone, Trazodone, Trimipramine
4	5-hydroxytryptamine receptor 1A inhibitors	Amitriptyline, Escitalopram, Tianeptine
5	5-hydroxytryptamine receptor 1A inducers	Amitriptyline
6	5-hydroxytryptamine receptor 1A binders	Desipramine, Dopamine, Loxapine
7	5-hydroxytryptamine receptor 1A activators	Imipramine
8	5-hydroxytryptamine receptor 1A blockers	Mianserin

	Interacting Group	Interacting Drugs
	Pramipexole is a Alpha-2A adrenergic receptor agonist
1	Alpha-2A adrenergic receptor agonists	4-Methoxyamphetamine, Amitriptyline, Apomorphine, Apraclonidine, Benzphetamine, Brimonidine, Bromocriptine, Clonidine, Dexmedetomidine, Dihydroergotamine, Dipivefrin, DL-Methylephedrine, Droxidopa, Ephedra sinica root, Epinephrine, Guanabenz, Guanfacine, Lofexidine, Metamfetamine, Moxonidine, Naphazoline, Norepinephrine, Oxymetazoline, Pseudoephedrine, Racepinephrine, Xylometazoline
2	Alpha-2A adrenergic receptor antagonists	Amitriptyline, Amoxapine, Aripiprazole, Asenapine, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Methotrimeprazine, Mianserin, Mirtazapine, Nefazodone, Paliperidone, Periciazine, Phenoxybenzamine, Phentolamine, Pipamperone, Pirlindole, Pizotifen, Quetiapine, Tolazoline, Trazodone, Yohimbine, Ziprasidone, Zuclopenthixol
3	Alpha-2A adrenergic receptor partial agonists	Ergotamine, Oxymetazoline
4	Alpha-2A adrenergic receptor binders	Loxapine, Prazosin
5	Alpha-2A adrenergic receptor inhibitors	Lamotrigine

	Interacting Group	Interacting Drugs
	Pramipexole is a Solute carrier family 22 member 2 substrate
1	Solute carrier family 22 member 2 inhibitors	Abemaciclib, Amantadine, Amiloride, Aminohippuric acid, Amiodarone, Apalutamide, Baricitinib, Bupropion, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Cisplatin, Clopidogrel, Cocaine, Desipramine, Dexchlorpheniramine maleate, Dinoprostone, Diphenhydramine, Disopyramide, Dolutegravir, Dopamine, Dronedarone, Enasidenib, Erdafitinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Famotidine, Flurazepam, Grepafloxacin, Guanidine, Histamine, Imatinib, Imipramine, Isavuconazole, Lamotrigine, Lenvatinib, Levofloxacin, Linagliptin, Metformin, Methylene blue, Metoprolol, Nicotine, Norepinephrine, Osilodrostat, Oxprenolol, Pemigatinib, Phenformin, Phenoxybenzamine, Pimagedine, Probenecid, Procainamide, Progesterone, Propranolol, Quinacrine, Quinidine, Quinine, Rimegepant, Salmeterol, Tafenoquine, Thiamine, Tirbanibulin, Trilaciclib, Tucatinib, Ubrogepant, Vandetanib, Varenicline
2	Solute carrier family 22 member 2 substrates	Agmatine, Amantadine, Choline, Choline salicylate, Cimetidine, Cisplatin, Dalfampridine, Dofetilide, Dopamine, Epinephrine, Guanfacine, Histamine, Lamivudine, Linagliptin, Memantine, Metformin, Nafamostat, Norepinephrine, Oxaliplatin, Ranitidine, Reserpine, Sulpiride, Terbutaline, Tetraethylammonium, Tipiracil, Varenicline

	Interacting Group	Interacting Drugs
	Pramipexole is a Solute carrier family 22 member 1 substrate
1	Solute carrier family 22 member 1 substrates	Acetylcholine, Acyclovir, Agmatine, Amantadine, Buformin, Choline, Choline salicylate, Cimetidine, Codeine, Dexchlorpheniramine maleate, Dopamine, Epinephrine, Formoterol, Ganciclovir, Guanfacine, Imatinib, Lamivudine, Lamotrigine, Metformin, Nafamostat, Nintedanib, Norepinephrine, Pancuronium, Phenformin, Prazosin, Quinine, Ranitidine, Rocuronium, Salmeterol, Spermidine, Spermine, Sulpiride, Thiamine, Tubocurarine
2	Solute carrier family 22 member 1 inhibitors	Acyclovir, Amantadine, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Clopidogrel, Codeine, Dacomitinib, Desipramine, Dexchlorpheniramine maleate, Disopyramide, Doxazosin, Dronedarone, Efavirenz, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Formoterol, Ganciclovir, Gilteritinib, Guanfacine, Guanidine, Indinavir, Lasmiditan, Levofloxacin, Linagliptin, Lurbinectedin, Nelfinavir, Nevirapine, Nicotine, Nintedanib, Osilodrostat, Palbociclib, Phenoxybenzamine, Pitolisant, Prazosin, Probenecid, Procainamide, Progesterone, Quinidine, Quinine, Ranitidine, Reserpine, Rucaparib, Salmeterol, Saquinavir, Tirbanibulin, Verapamil