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Identification
Name Bentoquatam
Accession Number DB00516 (APRD00819)
Type small molecule
Groups approved
Description

Bentoquatam is a topical medication intended to act as a shield against exposure to the irritating substance urushiol, found in plants such as poison ivy or poison oak. Bentoquatam contains bentonite, a clay, and is only effective as long as the film is visible on the skin.
Structure Thumb
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Synonyms Not Available
Brand names
  • Bentone 34
  • Ivy Block
  • IvyBlock
Brand name mixtures Not Available
Categories
  • Skin protectant, barrier (topical)
CAS number 1340-69-8
Weight Average: 180.0609
Monoisotopic: 179.925141211
Chemical Formula Al2H2O6Si
InChI Key InChIKey=SVPXDRXYRYOSEX-UHFFFAOYSA-N
InChI
InChI=1S/2Al.O2Si.H2O.3O/c;;1-3-2;;;;/h;;;1H2;;;
Plain Text
IUPAC Name
oxo[(oxoalumanyl)oxy]alumane silanedione hydrate
SMILES
O.O=[Si]=O.O=[Al]O[Al]=O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Inorganic
Classes
  • Inorganic Ions and Gases
Substructures
  • Inorganic Ions and Gases
Pharmacology
Indication Used to prevent or reduce the severity of allergic contact dermatitis due to urushiol, the allergenic resin of poison ivy, poison oak, and poison sumac.
Pharmacodynamics Bentoquatam protects the skin like a shield against poison ivy, poison oak, and poison sumac by physically blocking skin contact with their resin. The best protection against getting these conditions is to avoid contact with these plants. This medicine does not dry oozing and weeping caused by the rash of poison ivy, poison oak, or poison sumac.
Mechanism of action The mechanism of action is unknown. It is thought topically applied bentoquatam acts as a physical barrier that interferes with the adsorption of antigens onto the skin and reduces absorption of antigens into the skin. It probably does not work by modifying the systemic allergic response.
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Rare side effects include mild erythema (mild redness of skin).
Affected organisms
  • Humans and other mammals
Pathways Not Available
Pharmacoeconomics
Manufacturers
  • Standard homeopathic co
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Melting point Not Available
Experimental Properties
Property Value Source
water solubility Soluble PhysProp
Predicted Properties
Property Value Source
water solubility ALOGPS
logP ALOGPS
logP 2.47 ChemAxon Molconvert
logS ALOGPS
pKa ChemAxon Molconvert
hydrogen acceptor count 2 ChemAxon Molconvert
hydrogen donor count 0 ChemAxon Molconvert
polar surface area 43.37 ChemAxon Molconvert
rotatable bond count 2 ChemAxon Molconvert
refractivity 4.24 ChemAxon Molconvert
polarizability 6.44 ChemAxon Molconvert
References
Synthesis Reference Not Available
General Reference
  1. Scott MJ, Heumann MA, DeBruyckere DM, Brundage TW, Kohn MA: The feasibility of using skin protectant products and education to prevent poison oak. Wilderness Environ Med. 2002 Fall;13(3):206-8. Pubmed
External Links
Resource Link
PubChem Compound 517273 Link_out
PubChem Substance 46508055 Link_out
ChemSpider 451302 Link_out
PharmGKB PA448570 Link_out
Drug Product Database 0 Link_out
Drugs.com http://www.drugs.com/mtm/bentoquatam-topical.html Link_out
Wikipedia http://en.wikipedia.org/wiki/Bentoquatam Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries Not Available
FDA label Not Available
MSDS show (86.6 KB)
Interactions
Drug Interactions
Drug Interaction
Food Interactions Not Available
Comments
Drug created on June 13, 2005 07:24 / Updated on July 23, 2011 21:31

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.