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Identification
NameLamotrigine
Accession NumberDB00555  (APRD00570)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. The exact way lamotrigine works is unknown. [Wikipedia]

Structure
Thumb
Synonyms
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
Lamictal
Lamotrigina
Lamotrigine
Lamotriginum
External Identifiers
  • BW 430 C
  • GW 273293
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Auro-lamotriginetablet150 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Auro-lamotriginetablet100 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Auro-lamotriginetablet25 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Dom-lamotriginetablet25 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-lamotriginetablet150 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-lamotriginetablet100 mgoralDominion PharmacalNot applicableNot applicableCanada
Lamictaltablet2 mgoralGlaxosmithkline Inc2001-09-13Not applicableCanada
Lamictaltablet, chewable5 mg/1oralGlaxo Smith Kline Llc1998-09-04Not applicableUs
Lamictaltablet100 mg/1oralPhysicians Total Care, Inc.2008-05-09Not applicableUs
Lamictaltablet200 mg/1oralGlaxo Smith Kline Llc1995-01-18Not applicableUs
Lamictaltablet150 mg/1oralRebel Distributors Corp1995-01-17Not applicableUs
Lamictaltablet5 mgoralGlaxosmithkline Inc1999-06-02Not applicableCanada
Lamictaltablet25 mg/1oralPhysicians Total Care, Inc.2011-02-16Not applicableUs
Lamictaltablet150 mg/1oralGlaxo Smith Kline Llc1995-01-17Not applicableUs
Lamictaltablet100 mg/1oralRebel Distributors Corp1995-01-17Not applicableUs
Lamictaltablet25 mgoralGlaxosmithkline Inc1995-12-31Not applicableCanada
Lamictaltablet100 mg/1oralGlaxo Smith Kline Llc1995-01-17Not applicableUs
Lamictaltablet150 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not applicableUs
Lamictaltablet100 mgoralGlaxosmithkline Inc1995-12-31Not applicableCanada
Lamictaltablet200 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not applicableUs
Lamictaltablet25 mg/1oralGlaxo Smith Kline Llc1996-08-15Not applicableUs
LamictalkitGlaxo Smith Kline Llc2003-09-29Not applicableUs
Lamictaltablet150 mgoralGlaxosmithkline Inc1995-12-31Not applicableCanada
Lamictaltablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not applicableUs
LamictalkitGlaxo Smith Kline Llc2003-09-29Not applicableUs
Lamictaltablet100 mg/1oralPd Rx Pharmaceuticals, Inc.1995-01-17Not applicableUs
Lamictaltablet100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not applicableUs
Lamictaltablet, chewable25 mg/1oralGlaxo Smith Kline Llc1998-09-03Not applicableUs
Lamictaltablet200 mg/1oralPhysicians Total Care, Inc.2007-05-27Not applicableUs
Lamictaltablet, chewable2 mg/1oralGlaxo Smith Kline Llc2000-10-12Not applicableUs
Lamictal - Tab 200mgtablet200 mgoralGlaxo Wellcome Inc.1995-12-312001-05-25Canada
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTtablet, orally disintegrating200 mg/1oralGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTtablet, orally disintegrating100 mg/1oralGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTtablet, orally disintegrating50 mg/1oralGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTtablet, orally disintegrating25 mg/1oralGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release300 mg/1oralGlaxo Smith Kline Llc2011-03-31Not applicableUs
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release200 mg/1oralGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release100 mg/1oralGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release50 mg/1oralGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release250 mg/1oralGlaxo Smith Kline Llc2011-08-15Not applicableUs
Lamictal XRtablet, film coated, extended release25 mg/1oralGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamotriginetablet25 mg/1oralRebel Distributors Corp2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralRebel Distributors Corp2009-01-27Not applicableUs
Lamotriginetablet100 mgoralSanis Health Inc2010-02-16Not applicableCanada
Lamotriginetablet100 mgoralSivem Pharmaceuticals Ulc2014-10-08Not applicableCanada
Lamotriginetablet25 mgoralSivem Pharmaceuticals Ulc2014-10-08Not applicableCanada
Lamotriginetablet150 mg/1oralRebel Distributors Corp2009-01-27Not applicableUs
Lamotriginetablet25 mgoralSanis Health Inc2010-02-16Not applicableCanada
Lamotriginetablet100 mg/1oralRebel Distributors Corp2009-01-27Not applicableUs
Lamotriginetablet150 mgoralSanis Health Inc2010-02-16Not applicableCanada
Lamotriginetablet150 mgoralSivem Pharmaceuticals Ulc2014-10-08Not applicableCanada
Lamotrigine-100tablet100 mgoralPro Doc Limitee2008-03-08Not applicableCanada
Lamotrigine-150tablet150 mgoralPro Doc Limitee2008-03-07Not applicableCanada
Lamotrigine-25tablet25 mgoralPro Doc Limitee2008-03-07Not applicableCanada
Mylan-lamotriginetablet150 mgoralMylan Pharmaceuticals Ulc2005-04-01Not applicableCanada
Mylan-lamotriginetablet100 mgoralMylan Pharmaceuticals Ulc2005-04-01Not applicableCanada
Mylan-lamotriginetablet25 mgoralMylan Pharmaceuticals Ulc2005-04-01Not applicableCanada
Nu-lamotriginetablet100 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lamotriginetablet25 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lamotriginetablet150 mgoralNu Pharm IncNot applicableNot applicableCanada
PHL-lamotriginetablet150 mgoralPharmel IncNot applicableNot applicableCanada
PHL-lamotriginetablet100 mgoralPharmel IncNot applicableNot applicableCanada
PHL-lamotriginetablet25 mgoralPharmel IncNot applicableNot applicableCanada
PMS-lamotriginetablet150 mgoralPharmascience Inc2003-04-14Not applicableCanada
PMS-lamotriginetablet100 mgoralPharmascience Inc2003-04-14Not applicableCanada
PMS-lamotriginetablet25 mgoralPharmascience Inc2003-04-14Not applicableCanada
Ratio-lamotriginetablet25 mgoralTeva Canada Limited2002-08-28Not applicableCanada
Ratio-lamotriginetablet150 mgoralTeva Canada Limited2004-01-05Not applicableCanada
Ratio-lamotriginetablet100 mgoralTeva Canada Limited2002-08-30Not applicableCanada
Teva-lamotriginetablet100 mgoralTeva Canada Limited2004-01-16Not applicableCanada
Teva-lamotriginetablet25 mgoralTeva Canada Limited2004-01-16Not applicableCanada
Teva-lamotriginetablet150 mgoralTeva Canada Limited2004-01-16Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lamotriginetablet150 mgoralApotex Inc2002-03-18Not applicableCanada
Apo-lamotriginetablet100 mgoralApotex Inc2002-03-18Not applicableCanada
Apo-lamotriginetablet25 mgoralApotex Inc2002-03-18Not applicableCanada
LamotriginekitTorrent Pharmaceuticals Limited2009-09-14Not applicableUs
Lamotriginetablet25 mg/1oralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not applicableUs
Lamotriginetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lamotriginetablet150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-07-22Not applicableUs
Lamotriginetablet, extended release50 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet25 mg/1oralHikma Pharmaceutical2011-04-19Not applicableUs
Lamotriginetablet200 mg/1oralDIRECT RX2015-01-01Not applicableUs
Lamotriginetablet, extended release300 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet, chewable5 mg/1oralAurobindo Pharma Limited2009-11-04Not applicableUs
Lamotriginetablet150 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralCipla USA Inc.2010-11-01Not applicableUs
LamotriginekitPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet25 mg/1oralWest ward Pharmaceutical Corp2011-04-19Not applicableUs
Lamotriginetablet25 mg/1oralTeva Pharmaceuticals USA Inc2008-07-22Not applicableUs
LamotriginekitSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, extended release50 mg/1oralTorrent Pharmaceuticals Limited2013-12-23Not applicableUs
Lamotriginetablet150 mg/1oralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not applicableUs
Lamotriginetablet150 mg/1oralREMEDYREPACK INC.2011-07-29Not applicableUs
Lamotriginetablet200 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not applicableUs
LamotriginekitUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet25 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lamotriginetablet, extended release200 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet150 mg/1oralHikma Pharmaceutical2011-04-19Not applicableUs
Lamotriginetablet25 mg/1oralProficient Rx LP2011-11-01Not applicableUs
Lamotriginetablet100 mg/1oralTYA Pharmaceuticals2011-11-01Not applicableUs
Lamotriginetablet25 mg/1oralAscend Laboratories, LLC2011-06-22Not applicableUs
Lamotriginetablet250 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralMc Kesson Contract Packaging2013-05-13Not applicableUs
Lamotriginetablet, for suspension25 mg/1oralAlembic Pharmaceuticals Inc.2014-04-11Not applicableUs
Lamotriginetablet100 mg/1oralUpsher Smith Laboratories, Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralSTAT Rx USA LLC2010-12-07Not applicableUs
Lamotriginetablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-09Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2013-04-15Not applicableUs
Lamotriginetablet100 mg/1oralUnit Dose Services2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2013-05-07Not applicableUs
Lamotriginetablet100 mg/1oralMylan Pharmaceuticals Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralDr.Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release25 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet, chewable5 mg/1oralJubilant Cadista Pharmaceuticals Inc.2011-03-20Not applicableUs
Lamotriginetablet100 mg/1oralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2011-06-08Not applicableUs
Lamotriginetablet250 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralAmerican Health Packaging2013-07-05Not applicableUs
Lamotriginetablet100 mg/1oralGlenmark Pharmaceuticals Inc., Usa2012-05-04Not applicableUs
Lamotriginetablet, for suspension25 mg/1oralAlembic Pharmaceuticals Limited2016-01-29Not applicableUs
Lamotriginetablet, film coated, extended release100 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet, orally disintegrating25 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not applicableUs
Lamotriginetablet100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-07-22Not applicableUs
Lamotriginetablet, extended release25 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet150 mg/1oralClinical Solutions Wholesale2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2015-03-11Not applicableUs
Lamotriginetablet, extended release50 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet200 mg/1oralAurobindo Pharma Limited2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralCipla USA Inc.2010-11-01Not applicableUs
LamotriginekitPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet100 mg/1oralWest ward Pharmaceutical Corp2011-04-19Not applicableUs
Lamotriginetablet200 mg/1oralTorrent Pharmaceuticals Limited2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralREMEDYREPACK INC.2013-04-22Not applicableUs
Lamotriginetablet100 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not applicableUs
Lamotriginetablet, film coated, extended release200 mg/1oralWilshire Pharmaceuticals, Inc.2014-03-17Not applicableUs
Lamotriginetablet25 mg/1oralUpsher Smith Laboratories, Inc.2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralSTAT Rx USA LLC2010-12-07Not applicableUs
Lamotriginetablet100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-09Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-05-10Not applicableUs
Lamotriginetablet200 mg/1oralAv Pak2015-06-25Not applicableUs
Lamotriginetablet150 mg/1oralREMEDYREPACK INC.2013-03-27Not applicableUs
Lamotriginetablet25 mg/1oralMylan Pharmaceuticals Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralDr.Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet100 mg/1oralCardinal Health2009-12-22Not applicableUs
Lamotriginetablet200 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-01-20Not applicableUs
Lamotriginetablet200 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralAmerican Health Packaging2013-07-05Not applicableUs
Lamotriginetablet25 mg/1oralGlenmark Pharmaceuticals Inc., Usa2012-05-04Not applicableUs
Lamotriginetablet, for suspension5 mg/1oralAlembic Pharmaceuticals Limited2016-01-29Not applicableUs
Lamotriginetablet, film coated, extended release25 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet200 mg/1oralTeva Pharmaceuticals USA Inc2008-07-22Not applicableUs
Lamotriginetablet, extended release300 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet100 mg/1oralClinical Solutions Wholesale, Llc2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralApotex Corp2009-01-27Not applicableUs
Lamotriginetablet, extended release100 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet150 mg/1oralAurobindo Pharma Limited2009-01-27Not applicableUs
Lamotriginetablet50 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralCipla USA Inc.2010-11-01Not applicableUs
LamotriginekitPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet150 mg/1oralWest ward Pharmaceutical Corp2011-04-19Not applicableUs
Lamotriginetablet150 mg/1oralTorrent Pharmaceuticals Limited2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2011-12-13Not applicableUs
Lamotriginetablet200 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralMylan Institutional Inc.2009-06-19Not applicableUs
Lamotriginetablet, film coated, extended release100 mg/1oralWilshire Pharmaceuticals, Inc.2014-03-17Not applicableUs
Lamotriginetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-07-22Not applicableUs
Lamotriginetablet200 mg/1oralUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet150 mg/1oralPhysicians Total Care, Inc.2012-01-04Not applicableUs
Lamotriginetablet25 mg/1oralCardinal Health2009-12-22Not applicableUs
Lamotriginetablet150 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralbryant ranch prepack2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralAmerican Health Packaging2013-07-05Not applicableUs
Lamotriginetablet, chewable25 mg/1oralGlenmark Pharmaceuticals Inc., Usa2009-02-19Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2016-03-11Not applicableUs
Lamotriginetablet150 mg/1oralTeva Pharmaceuticals USA Inc2008-07-22Not applicableUs
Lamotriginetablet200 mg/1oralSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, chewable25 mg/1oralCobalt Laboratories2009-07-29Not applicableUs
Lamotriginetablet200 mg/1oralAidarex Pharmaceuticals LLC2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2013-03-05Not applicableUs
Lamotriginetablet150 mg/1oralAv Pak2015-06-25Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-02-28Not applicableUs
Lamotriginetablet, chewable25 mg/1oralDr. Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release300 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet150 mg/1oralApotex Corp2009-01-27Not applicableUs
Lamotriginetablet, extended release200 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet100 mg/1oralAurobindo Pharma Limited2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralCipla USA Inc.2010-11-01Not applicableUs
Lamotriginetablet, orally disintegrating200 mg/1oralPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet200 mg/1oralREMEDYREPACK INC.2014-08-25Not applicableUs
Lamotriginetablet200 mg/1oralWest ward Pharmaceutical Corp2011-04-19Not applicableUs
Lamotriginetablet100 mg/1oralTorrent Pharmaceuticals Limited2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralNorth Star Rx Llc2013-01-01Not applicableUs
Lamotriginetablet200 mg/1oralAv Kare, Inc.2013-04-03Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-02-27Not applicableUs
Lamotriginetablet150 mg/1oralMylan Institutional Inc.2009-06-19Not applicableUs
Lamotriginetablet, film coated, extended release50 mg/1oralWilshire Pharmaceuticals, Inc.2014-03-17Not applicableUs
Lamotriginetablet, chewable25 mg/1oralMylan Pharmaceuticals Inc.2009-01-26Not applicableUs
Lamotriginetablet25 mg/1oralPhysicians Total Care, Inc.2009-12-09Not applicableUs
Lamotriginetablet100 mg/1oralCardinal Health2012-08-24Not applicableUs
Lamotriginetablet100 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralbryant ranch prepack2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralAscend Laboratories, LLC2011-06-22Not applicableUs
Lamotriginetablet, chewable5 mg/1oralGlenmark Pharmaceuticals Inc., Usa2009-02-19Not applicableUs
Lamotriginetablet150 mg/1oralREMEDYREPACK INC.2016-03-11Not applicableUs
Lamotriginetablet, chewable5 mg/1oralTeva Pharmaceuticals USA Inc2006-08-28Not applicableUs
Lamotriginetablet150 mg/1oralSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, chewable5 mg/1oralCobalt Laboratories2009-07-29Not applicableUs
Lamotriginetablet100 mg/1oralAidarex Pharmaceuticals LLC2011-11-01Not applicableUs
Lamotriginetablet200 mg/1oralREMEDYREPACK INC.2011-08-23Not applicableUs
Lamotriginetablet100 mg/1oralAv Pak2015-06-25Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2013-02-22Not applicableUs
Lamotriginetablet150 mg/1oralUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet, chewable5 mg/1oralDr. Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release50 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet100 mg/1oralApotex Corp2009-01-27Not applicableUs
Lamotriginetablet, extended release25 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet25 mg/1oralAurobindo Pharma Limited2009-01-27Not applicableUs
Lamotriginetablet, chewable5 mg/1oralCarilion Materials Management2008-08-28Not applicableUs
Lamotriginetablet150 mg/1oralPreferred Pharmaceuticals, Inc.2014-01-20Not applicableUs
Lamotriginetablet, orally disintegrating100 mg/1oralPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet, film coated, extended release300 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet, orally disintegrating200 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not applicableUs
Lamotriginetablet25 mg/1oralTorrent Pharmaceuticals Limited2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralNorth Star Rx Llc2013-01-01Not applicableUs
Lamotriginetablet150 mg/1oralAv Kare, Inc.2013-04-03Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-02-08Not applicableUs
Lamotriginetablet100 mg/1oralMylan Institutional Inc.2009-03-02Not applicableUs
Lamotriginetablet, film coated, extended release25 mg/1oralWilshire Pharmaceuticals, Inc.2014-03-17Not applicableUs
Lamotriginetablet, chewable5 mg/1oralMylan Pharmaceuticals Inc.2009-01-26Not applicableUs
Lamotriginetablet200 mg/1oralPhysicians Total Care, Inc.2008-12-05Not applicableUs
Lamotriginetablet25 mg/1oralCardinal Health2012-08-24Not applicableUs
Lamotriginetablet25 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralbryant ranch prepack2009-01-27Not applicableUs
Lamotriginetablet50 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralAscend Laboratories, LLC2011-06-22Not applicableUs
Lamotriginetablet, chewable25 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-23Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2016-03-04Not applicableUs
Lamotriginetablet100 mg/1oralTeva Pharmaceuticals USA Inc2008-07-22Not applicableUs
Lamotriginetablet100 mg/1oralSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, extended release200 mg/1oralTorrent Pharmaceuticals Limited2013-12-23Not applicableUs
Lamotriginetablet25 mg/1oralAidarex Pharmaceuticals LLC2009-01-27Not applicableUs
Lamotriginetablet, chewable25 mg/1oralREMEDYREPACK INC.2011-09-08Not applicableUs
Lamotriginetablet25 mg/1oralAv Pak2015-06-25Not applicableUs
Lamotriginetablet, chewable25 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-02-04Not applicableUs
Lamotriginetablet100 mg/1oralUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet, orally disintegrating100 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not applicableUs
Lamotriginetablet200 mg/1oralUpsher Smith Laboratories, Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralNorth Star Rx Llc2013-01-01Not applicableUs
Lamotriginetablet100 mg/1oralAv Kare, Inc.2013-04-03Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-04-22Not applicableUs
Lamotriginetablet25 mg/1oralMylan Institutional Inc.2009-03-02Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2014-05-19Not applicableUs
Lamotriginetablet200 mg/1oralMylan Pharmaceuticals Inc.2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralDr.Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release100 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet25 mg/1oralApotex Corp2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralMc Kesson Packaging Sevices A Business Unit Of Mc Kesson Corporation2014-02-05Not applicableUs
Lamotriginetablet, chewable25 mg/1oralCadila Healthcare Limited2009-01-23Not applicableUs
Lamotriginetablet200 mg/1oralAmerican Health Packaging2014-08-28Not applicableUs
Lamotriginetablet200 mg/1oralGlenmark Pharmaceuticals Inc., Usa2012-05-04Not applicableUs
Lamotriginetablet, orally disintegrating50 mg/1oralPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet, film coated, extended release200 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet, extended release25 mg/1oralTorrent Pharmaceuticals Limited2013-12-23Not applicableUs
Lamotriginetablet100 mg/1oralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not applicableUs
Lamotriginetablet150 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lamotriginetablet200 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-07-22Not applicableUs
Lamotriginetablet, extended release100 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet100 mg/1oralHikma Pharmaceutical2011-04-19Not applicableUs
Lamotriginetablet100 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lamotriginetablet25 mg/1oralTYA Pharmaceuticals2011-11-01Not applicableUs
Lamotriginetablet, chewable25 mg/1oralAurobindo Pharma Limited2009-11-04Not applicableUs
Lamotriginetablet200 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralMc Kesson Contract Packaging2011-11-30Not applicableUs
Lamotriginetablet, for suspension5 mg/1oralAlembic Pharmaceuticals Inc.2014-04-11Not applicableUs
LamotriginekitUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet100 mg/1oralPhysicians Total Care, Inc.2008-07-30Not applicableUs
Lamotriginetablet100 mg/1oralCardinal Health2009-09-22Not applicableUs
Lamotriginetablet200 mg/1oralHikma Pharmaceutical2011-04-19Not applicableUs
Lamotriginetablet100 mg/1oralbryant ranch prepack2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralAscend Laboratories, LLC2011-06-22Not applicableUs
Lamotriginetablet, chewable5 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-23Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2015-12-30Not applicableUs
Lamotriginetablet, chewable25 mg/1oralAvera Mc Kennan Hospital2015-04-16Not applicableUs
Lamotriginetablet, chewable25 mg/1oralTeva Pharmaceuticals USA Inc2006-06-29Not applicableUs
Lamotriginetablet25 mg/1oralSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, extended release100 mg/1oralTorrent Pharmaceuticals Limited2013-12-23Not applicableUs
Lamotriginetablet200 mg/1oralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2011-08-23Not applicableUs
Lamotriginetablet, chewable5 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-02-04Not applicableUs
Lamotriginetablet25 mg/1oralUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet150 mg/1oralUpsher Smith Laboratories, Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralNorth Star Rx Llc2013-01-01Not applicableUs
Lamotriginetablet25 mg/1oralAv Kare, Inc.2013-04-03Not applicableUs
Lamotriginetablet200 mg/1oralREMEDYREPACK INC.2013-05-09Not applicableUs
Lamotriginetablet25 mg/1oralUnit Dose Services2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralREMEDYREPACK INC.2014-03-04Not applicableUs
Lamotriginetablet150 mg/1oralMylan Pharmaceuticals Inc.2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralDr.Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release200 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet, chewable25 mg/1oralJubilant Cadista Pharmaceuticals Inc.2011-03-20Not applicableUs
Lamotriginetablet200 mg/1oralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2011-06-08Not applicableUs
Lamotriginetablet, chewable5 mg/1oralCadila Healthcare Limited2009-01-23Not applicableUs
Lamotriginetablet, chewable25 mg/1oralAmerican Health Packaging2011-06-17Not applicableUs
Lamotriginetablet150 mg/1oralGlenmark Pharmaceuticals Inc., Usa2012-05-04Not applicableUs
Lamotriginetablet, orally disintegrating25 mg/1oralPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet, film coated, extended release50 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet, orally disintegrating50 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not applicableUs
Lamotrigine Extended Releasetablet100 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet250 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet50 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet25 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet200 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet300 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ConvulsanActavis
CrisometJuste
DafexPhoenix
DaksolPharmavita
DanoptinPliva
DezepilRafarm
ElmendosGlaxoSmithKline
EpilepaxIvax
EpimilIvax
EpiralZentiva
EpitecCipla Medpro
EpitrigineActavis
LabilenoGlaxoSmithKline
LambipolGlaxoSmithKline
LamectPharmaSwiss
LameptilSandoz
Lameptil SSandoz
LametecVitalchem
LamezIntas
Lamictal CDGlaxoSmithKline
LamictinGlaxoSmithKline
LamotrixGlenmark
LarigRowex
MedotriginMedochemie
MogineDouglas
TrimolepPsicofarma
TrogineRanbaxy
XebarinDr Reddys
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIU3H27498KS
CAS number84057-84-1
WeightAverage: 256.091
Monoisotopic: 255.007850663
Chemical FormulaC9H7Cl2N5
InChI KeyInChIKey=PYZRQGJRPPTADH-UHFFFAOYSA-N
InChI
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
IUPAC Name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
SMILES
NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassHalobenzenes
Direct ParentDichlorobenzenes
Alternative Parents
Substituents
  • 1,2-dichlorobenzene
  • Aminotriazine
  • 1,2,4-triazine
  • Imidolactam
  • Triazine
  • Primary aromatic amine
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Primary amine
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.
PharmacodynamicsLamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is also used in the treatment of depression and bipolar disorder. Lamotrigine is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Lamotrigine inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate.
Mechanism of actionOne proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. in vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels and/or calcium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate). Studies on lamotrigine show binding to sodium channels similar to local anesthetics.
Related Articles
Absorption98%
Volume of distribution
  • 0.9 to 1.3 L/kg
Protein binding55%
Metabolism

Hepatic

SubstrateEnzymesProduct
Lamotrigine
lamotrigine-2-N-glucuronideDetails
Route of eliminationNot Available
Half life25 +/- 10 hours (healthy individuals); 42.9 hours (chronic renal failure)
Clearance
  • Apparent plasma cl=0.44 mL/min/kg [healthy volunteers taking single-dose LAMICTAL]
  • Apparent plasma cl=0.58 mL/min/kg [healthy volunteers taking multiple-dose LAMICTAL]
  • Apparent plasma cl=0.30 mL/min/kg [healthy volunteers taking valproate and single-dose LAMICTAL]
  • Apparent plasma cl=0.18 mL/min/kg [healthy volunteers taking valproate and multiple-dose LAMICTAL]
  • Apparent plasma cl=1.1 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and single-dose LAMICTAL]
  • Apparent plasma cl=1.12 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and multiple-dose LAMICTAL]
ToxicityLD50=250 (mg/kg) (in rat, mice); LD50>640 orally (mg/kg) (in rat, mice) (Sawyer). Symptoms of overdose include decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, and rolling eyeballs.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9382
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.7155
P-glycoprotein inhibitor INon-inhibitor0.911
P-glycoprotein inhibitor IINon-inhibitor0.9604
Renal organic cation transporterNon-inhibitor0.8176
CYP450 2C9 substrateNon-substrate0.9162
CYP450 2D6 substrateNon-substrate0.9055
CYP450 3A4 substrateNon-substrate0.6862
CYP450 1A2 substrateNon-inhibitor0.611
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.7007
CYP450 2C19 inhibitorNon-inhibitor0.8594
CYP450 3A4 inhibitorNon-inhibitor0.7678
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5515
Ames testNon AMES toxic0.8202
CarcinogenicityNon-carcinogens0.7895
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.7556 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9168
hERG inhibition (predictor II)Non-inhibitor0.8735
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Glaxosmithkline
  • Aurobindo pharma ltd
  • Dr reddys laboratories ltd
  • Glenmark generics ltd
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Taro pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Zydus pharmaceuticals usa inc
  • Smithkline beecham corp
  • Smithkline beecham corp dba glaxosmithkline
  • Apotex inc
  • Cadista pharmaceuticals inc
  • Lupin ltd
  • Matrix laboratories ltd
  • Roxane laboratories inc
  • Torrent pharmaceuticals ltd
  • Upsher smith laboratories inc
  • Wockhardt ltd
Packagers
Dosage forms
FormRouteStrength
Kit
Tabletoral100 mg
Tabletoral150 mg
Tabletoral2 mg
Tabletoral25 mg
Tabletoral5 mg
Tablet, chewableoral2 mg/1
Tabletoral200 mg
Tablet, film coated, extended releaseoral100 mg/1
Tablet, film coated, extended releaseoral200 mg/1
Tablet, film coated, extended releaseoral25 mg/1
Tablet, film coated, extended releaseoral250 mg/1
Tablet, film coated, extended releaseoral300 mg/1
Tablet, film coated, extended releaseoral50 mg/1
Tabletoral100 mg/1
Tabletoral150 mg/1
Tabletoral200 mg/1
Tabletoral25 mg/1
Tablet, chewableoral25 mg/1
Tablet, chewableoral5 mg/1
Tablet, extended releaseoral100 mg/1
Tablet, extended releaseoral200 mg/1
Tablet, extended releaseoral25 mg/1
Tablet, extended releaseoral300 mg/1
Tablet, extended releaseoral50 mg/1
Tablet, for suspensionoral25 mg/1
Tablet, for suspensionoral5 mg/1
Tablet, orally disintegratingoral100 mg/1
Tablet, orally disintegratingoral200 mg/1
Tablet, orally disintegratingoral25 mg/1
Tablet, orally disintegratingoral50 mg/1
Tabletoral250 mg/1
Tabletoral300 mg/1
Tabletoral50 mg/1
Prices
Unit descriptionCostUnit
LaMICtal Starter 98 25 (84)-100(14)mg Kit Box556.69USD box
LaMICtal XR 200 mg 24 Hour tablet12.11USD tablet
Lamictal xr 200 mg tablet11.65USD tablet
LaMICtal XR 100 mg 24 Hour tablet11.36USD tablet
Lamictal xr 100 mg tablet10.92USD tablet
Lamictal xr 50 mg tablet10.2USD tablet
Lamictal 200 mg tablet7.44USD tablet
Lamictal odt start kt (orange)7.28USD tablet
Lamictal xr start kit (orange)7.28USD tablet
Lamictal odt 200 mg tablet6.95USD tablet
Lamictal odt 100 mg tablet5.82USD tablet
Lamotrigine 200 mg tablet5.78USD tablet
LaMICtal 25 mg Chew Tabs5.63USD tab
Lamictal odt 50 mg tablet5.46USD tablet
Lamictal tab start kit (green)5.46USD tablet
Lamictal 150 mg tablet5.38USD tablet
Lamictal odt 25 mg tablet5.1USD tablet
Lamictal xr 25 mg tablet5.1USD tablet
Lamictal 100 mg tablet4.72USD tablet
Lamotrigine tablet starter kit4.24USD tablet
Lamotrigine 150 mg tablet3.98USD tablet
Lamictal 25 mg tablet3.78USD tablet
Lamotrigine 100 mg tablet3.52USD tablet
LamoTRIgine 25 mg Chew Tabs3.33USD tab
LamoTRIgine 5 mg Chew Tabs3.18USD tab
Lamotrigine 25 mg tablet2.9USD tablet
Apo-Lamotrigine 150 mg Tablet1.31USD tablet
Mylan-Lamotrigine 150 mg Tablet1.31USD tablet
Novo-Lamotrigine 150 mg Tablet1.31USD tablet
Pms-Lamotrigine 150 mg Tablet1.31USD tablet
Ratio-Lamotrigine 150 mg Tablet1.31USD tablet
Apo-Lamotrigine 100 mg Tablet0.88USD tablet
Mylan-Lamotrigine 100 mg Tablet0.88USD tablet
Novo-Lamotrigine 100 mg Tablet0.88USD tablet
Pms-Lamotrigine 100 mg Tablet0.88USD tablet
Ratio-Lamotrigine 100 mg Tablet0.88USD tablet
Apo-Lamotrigine 25 mg Tablet0.22USD tablet
Mylan-Lamotrigine 25 mg Tablet0.22USD tablet
Novo-Lamotrigine 25 mg Tablet0.22USD tablet
Pms-Lamotrigine 25 mg Tablet0.22USD tablet
Ratio-Lamotrigine 25 mg Tablet0.22USD tablet
Lamictal 5 mg Chewable Tablet0.18USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2277722 No2001-03-272012-01-29Canada
US5698226 No1995-07-292012-07-29Us
US7919115 No2009-01-042029-01-04Us
US8637512 No2008-06-142028-06-14Us
US8840925 No2008-07-022028-07-02Us
US9144547 No2003-09-222023-09-22Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point216-218 °C (uncorr)Not Available
logP2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.488 mg/mLALOGPS
logP1.87ALOGPS
logP1.93ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)14.98ChemAxon
pKa (Strongest Basic)5.87ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area90.71 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity66.62 m3·mol-1ChemAxon
Polarizability23.1 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Grahame Roy Lee, “Process for the preparation of lamotrigine.” U.S. Patent US5925755, issued January, 1981.

US5925755
General References
  1. Backonja M: Neuromodulating drugs for the symptomatic treatment of neuropathic pain. Curr Pain Headache Rep. 2004 Jun;8(3):212-6. [PubMed:15115640 ]
  2. Barbosa L, Berk M, Vorster M: A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J Clin Psychiatry. 2003 Apr;64(4):403-7. [PubMed:12716240 ]
  3. Jensen TS: Anticonvulsants in neuropathic pain: rationale and clinical evidence. Eur J Pain. 2002;6 Suppl A:61-8. [PubMed:11888243 ]
  4. Pappagallo M: Newer antiepileptic drugs: possible uses in the treatment of neuropathic pain and migraine. Clin Ther. 2003 Oct;25(10):2506-38. [PubMed:14667954 ]
  5. Tehrani SP, Daryaafzoon M, Bakhtiarian A, Ejtemaeemehr S, Sahraei H: The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9. [PubMed:19579915 ]
External Links
ATC CodesN03AX09
AHFS Codes
  • 28:12.92
PDB EntriesNot Available
FDA labelDownload (3.15 MB)
MSDSDownload (28.6 KB)
Interactions
Drug Interactions
Drug
AcetaminophenThe metabolism of Lamotrigine can be increased when combined with Acetaminophen.
AmobarbitalThe metabolism of Lamotrigine can be increased when combined with Amobarbital.
AtazanavirThe serum concentration of Lamotrigine can be decreased when it is combined with Atazanavir.
Atracurium besylateLamotrigine may increase the neuromuscular blocking activities of Atracurium besylate.
AzelastineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Lamotrigine.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
BuprenorphineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
ButabarbitalThe metabolism of Lamotrigine can be increased when combined with Butabarbital.
ButalbitalThe metabolism of Lamotrigine can be increased when combined with Butalbital.
ButethalThe serum concentration of Lamotrigine can be decreased when it is combined with Butethal.
CaffeineThe metabolism of Lamotrigine can be increased when combined with Caffeine.
Calcium AcetateThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium Acetate.
Calcium carbonateThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium carbonate.
Calcium ChlorideThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium Chloride.
Calcium citrateThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium citrate.
Calcium gluconateThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium gluconate.
CarbamazepineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Carbamazepine.
ChlorotrianiseneThe serum concentration of Lamotrigine can be decreased when it is combined with Chlorotrianisene.
CimetidineThe serum concentration of Lamotrigine can be increased when it is combined with Cimetidine.
Cisatracurium besylateLamotrigine may increase the neuromuscular blocking activities of Cisatracurium besylate.
ClarithromycinThe metabolism of Lamotrigine can be decreased when combined with Clarithromycin.
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Lamotrigine.
DesmopressinThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Desmopressin.
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Lamotrigine.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Lamotrigine.
DoxazosinDoxazosin may increase the hypotensive activities of Lamotrigine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
EfavirenzThe serum concentration of Lamotrigine can be decreased when it is combined with Efavirenz.
ErythromycinThe metabolism of Lamotrigine can be decreased when combined with Erythromycin.
EthanolLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Lamotrigine.
EzogabineThe serum concentration of Lamotrigine can be decreased when it is combined with Ezogabine.
FluconazoleThe serum concentration of Lamotrigine can be increased when it is combined with Fluconazole.
FosphenytoinThe serum concentration of Lamotrigine can be decreased when it is combined with Fosphenytoin.
HeptabarbitalThe serum concentration of Lamotrigine can be decreased when it is combined with Heptabarbital.
HexobarbitalThe serum concentration of Lamotrigine can be decreased when it is combined with Hexobarbital.
HydrocodoneLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Lamotrigine.
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Lamotrigine.
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Lamotrigine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lamotrigine.
Magnesium chlorideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium chloride.
Magnesium citrateThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium citrate.
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium hydroxide.
Magnesium oxideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium oxide.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium salicylate.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone Acetate can be decreased when it is combined with Lamotrigine.
MefloquineThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Mefloquine.
MetforminThe serum concentration of Metformin can be increased when it is combined with Lamotrigine.
MethohexitalThe metabolism of Lamotrigine can be increased when combined with Methohexital.
MethotrimeprazineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetyrosineLamotrigine may increase the sedative activities of Metyrosine.
MianserinThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Mianserin.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
MirtazapineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
NafcillinThe metabolism of Lamotrigine can be increased when combined with Nafcillin.
NitroprussideLamotrigine may increase the hypotensive activities of Nitroprusside.
NorethisteroneThe serum concentration of Norethindrone can be decreased when it is combined with Lamotrigine.
OlanzapineLamotrigine may increase the sedative activities of Olanzapine.
OrlistatThe serum concentration of Lamotrigine can be decreased when it is combined with Orlistat.
OrphenadrineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
PancuroniumLamotrigine may increase the neuromuscular blocking activities of Pancuronium.
ParaldehydeLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Paroxetine.
PentobarbitalThe metabolism of Lamotrigine can be increased when combined with Pentobarbital.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
PhenobarbitalThe metabolism of Lamotrigine can be increased when combined with Phenobarbital.
PhenoxybenzaminePhenoxybenzamine may increase the hypotensive activities of Lamotrigine.
PhentolaminePhentolamine may increase the hypotensive activities of Lamotrigine.
PhenytoinThe serum concentration of Lamotrigine can be decreased when it is combined with Phenytoin.
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Lamotrigine.
PramipexoleLamotrigine may increase the sedative activities of Pramipexole.
PrazosinPrazosin may increase the hypotensive activities of Lamotrigine.
PrimidoneThe serum concentration of Lamotrigine can be decreased when it is combined with Primidone.
ProcainamideThe serum concentration of Procainamide can be increased when it is combined with Lamotrigine.
RifabutinThe serum concentration of Lamotrigine can be decreased when it is combined with Rifabutin.
RifampicinThe metabolism of Lamotrigine can be increased when combined with Rifampicin.
RifapentineThe serum concentration of Lamotrigine can be decreased when it is combined with Rifapentine.
RitonavirThe serum concentration of Lamotrigine can be decreased when it is combined with Ritonavir.
RocuroniumLamotrigine may increase the neuromuscular blocking activities of Rocuronium.
RopiniroleLamotrigine may increase the sedative activities of Ropinirole.
RotigotineLamotrigine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Lamotrigine.
SecobarbitalThe metabolism of Lamotrigine can be increased when combined with Secobarbital.
SilodosinSilodosin may increase the hypotensive activities of Lamotrigine.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
SulfisoxazoleThe metabolism of Lamotrigine can be decreased when combined with Sulfisoxazole.
SuvorexantLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TamsulosinTamsulosin may increase the hypotensive activities of Lamotrigine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
TelithromycinThe metabolism of Lamotrigine can be decreased when combined with Telithromycin.
TerazosinTerazosin may increase the hypotensive activities of Lamotrigine.
ThalidomideLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Lamotrigine.
VecuroniumLamotrigine may increase the neuromuscular blocking activities of Vecuronium.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Lamotrigine.
ZolpidemLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Gene Name:
SCN2A
Uniprot ID:
Q99250
Molecular Weight:
227972.64 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Lipkind GM, Fozzard HA: Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels. Mol Pharmacol. 2005 Dec;68(6):1611-22. Epub 2005 Sep 20. [PubMed:16174788 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Protein homodimerization activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
Gene Name:
UGT1A4
Uniprot ID:
P22310
Molecular Weight:
60024.535 Da
References
  1. Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP: Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35. doi: 10.3109/00498250903188985. [PubMed:19845433 ]
  2. Chen H, Yang K, Choi S, Fischer JH, Jeong H: Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17beta-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy. Drug Metab Dispos. 2009 Sep;37(9):1841-7. doi: 10.1124/dmd.109.026609. Epub 2009 Jun 22. [PubMed:19546240 ]
  3. Argikar UA, Remmel RP: Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica. 2009 May;39(5):355-63. doi: 10.1080/00498250902745082. [PubMed:19387891 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A3
Uniprot ID:
P35503
Molecular Weight:
60337.835 Da
References
  1. Argikar UA, Remmel RP: Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica. 2009 May;39(5):355-63. doi: 10.1080/00498250902745082. [PubMed:19387891 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Luna-Tortos C, Fedrowitz M, Loscher W: Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. doi: 10.1016/j.neuropharm.2008.08.032. Epub 2008 Sep 11. [PubMed:18824002 ]
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Drug created on June 13, 2005 07:24 / Updated on July 28, 2016 01:51