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Identification
NameLamotrigine
Accession NumberDB00555  (APRD00570)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionLamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. The exact way lamotrigine works is unknown. [Wikipedia]
Structure
Thumb
Synonyms
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
Lamictal
Lamotrigina
Lamotrigine
Lamotriginum
External Identifiers
  • BW 430 C
  • GW 273293
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Auro-lamotriginetablet150 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Auro-lamotriginetablet25 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Auro-lamotriginetablet100 mgoralAuro Pharma Inc2012-06-13Not applicableCanada
Dom-lamotriginetablet25 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-lamotriginetablet100 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-lamotriginetablet150 mgoralDominion PharmacalNot applicableNot applicableCanada
Lamictaltablet, chewable2 mg/1oralGlaxo Smith Kline Llc2000-10-12Not applicableUs
Lamictaltablet200 mg/1oralPhysicians Total Care, Inc.2007-05-27Not applicableUs
Lamictaltablet, chewable5 mg/1oralGlaxo Smith Kline Llc1998-09-04Not applicableUs
Lamictaltablet2 mgoralGlaxosmithkline Inc2001-09-13Not applicableCanada
Lamictaltablet100 mg/1oralRebel Distributors Corp1995-01-17Not applicableUs
Lamictaltablet25 mgoralGlaxosmithkline Inc1995-12-31Not applicableCanada
Lamictaltablet100 mg/1oralGlaxo Smith Kline Llc1995-01-17Not applicableUs
Lamictaltablet150 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not applicableUs
Lamictaltablet100 mg/1oralPd Rx Pharmaceuticals, Inc.1995-01-17Not applicableUs
Lamictaltablet100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not applicableUs
Lamictaltablet, chewable25 mg/1oralGlaxo Smith Kline Llc1998-09-03Not applicableUs
Lamictaltablet150 mg/1oralRebel Distributors Corp1995-01-17Not applicableUs
Lamictaltablet5 mgoralGlaxosmithkline Inc1999-06-02Not applicableCanada
Lamictaltablet150 mg/1oralGlaxo Smith Kline Llc1995-01-17Not applicableUs
Lamictaltablet25 mg/1oralPhysicians Total Care, Inc.2011-02-16Not applicableUs
LamictalkitGlaxo Smith Kline Llc2003-09-29Not applicableUs
Lamictaltablet150 mgoralGlaxosmithkline Inc1995-12-31Not applicableCanada
LamictalkitGlaxo Smith Kline Llc2003-09-29Not applicableUs
Lamictaltablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not applicableUs
Lamictaltablet200 mg/1oralGlaxo Smith Kline Llc1995-01-18Not applicableUs
Lamictaltablet100 mg/1oralPhysicians Total Care, Inc.2008-05-09Not applicableUs
Lamictaltablet100 mgoralGlaxosmithkline Inc1995-12-31Not applicableCanada
Lamictaltablet25 mg/1oralGlaxo Smith Kline Llc1996-08-15Not applicableUs
Lamictaltablet200 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not applicableUs
Lamictal - Tab 200mgtablet200 mgoralGlaxo Wellcome Inc.1995-12-312001-05-25Canada
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTtablet, orally disintegrating200 mg/1oralGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTtablet, orally disintegrating25 mg/1oralGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTtablet, orally disintegrating50 mg/1oralGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal ODTtablet, orally disintegrating100 mg/1oralGlaxo Smith Kline Llc2009-06-05Not applicableUs
Lamictal XRtablet, film coated, extended release300 mg/1oralGlaxo Smith Kline Llc2011-03-31Not applicableUs
Lamictal XRtablet, film coated, extended release200 mg/1oralGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release25 mg/1oralGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release250 mg/1oralGlaxo Smith Kline Llc2011-08-15Not applicableUs
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release50 mg/1oralGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRtablet, film coated, extended release100 mg/1oralGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not applicableUs
Lamotriginetablet150 mgoralSivem Pharmaceuticals Ulc2014-10-08Not applicableCanada
Lamotriginetablet100 mgoralSanis Health Inc2010-02-16Not applicableCanada
Lamotriginetablet200 mg/1oralRebel Distributors Corp2009-01-27Not applicableUs
Lamotriginetablet150 mgoralSanis Health Inc2010-02-16Not applicableCanada
Lamotriginetablet25 mgoralSivem Pharmaceuticals Ulc2014-10-08Not applicableCanada
Lamotriginetablet25 mg/1oralRebel Distributors Corp2009-01-27Not applicableUs
Lamotriginetablet100 mgoralSivem Pharmaceuticals Ulc2014-10-08Not applicableCanada
Lamotriginetablet150 mg/1oralRebel Distributors Corp2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralRebel Distributors Corp2009-01-27Not applicableUs
Lamotriginetablet25 mgoralSanis Health Inc2010-02-16Not applicableCanada
Lamotrigine-100tablet100 mgoralPro Doc Limitee2008-03-08Not applicableCanada
Lamotrigine-150tablet150 mgoralPro Doc Limitee2008-03-07Not applicableCanada
Lamotrigine-25tablet25 mgoralPro Doc Limitee2008-03-07Not applicableCanada
Mylan-lamotriginetablet25 mgoralMylan Pharmaceuticals Ulc2005-04-01Not applicableCanada
Mylan-lamotriginetablet100 mgoralMylan Pharmaceuticals Ulc2005-04-01Not applicableCanada
Mylan-lamotriginetablet150 mgoralMylan Pharmaceuticals Ulc2005-04-01Not applicableCanada
Nu-lamotriginetablet25 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lamotriginetablet100 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lamotriginetablet150 mgoralNu Pharm IncNot applicableNot applicableCanada
PHL-lamotriginetablet150 mgoralPharmel IncNot applicableNot applicableCanada
PHL-lamotriginetablet25 mgoralPharmel IncNot applicableNot applicableCanada
PHL-lamotriginetablet100 mgoralPharmel IncNot applicableNot applicableCanada
PMS-lamotriginetablet25 mgoralPharmascience Inc2003-04-14Not applicableCanada
PMS-lamotriginetablet100 mgoralPharmascience Inc2003-04-14Not applicableCanada
PMS-lamotriginetablet150 mgoralPharmascience Inc2003-04-14Not applicableCanada
Ratio-lamotriginetablet150 mgoralTeva Canada Limited2004-01-05Not applicableCanada
Ratio-lamotriginetablet25 mgoralTeva Canada Limited2002-08-28Not applicableCanada
Ratio-lamotriginetablet100 mgoralTeva Canada Limited2002-08-30Not applicableCanada
Teva-lamotriginetablet150 mgoralTeva Canada Limited2004-01-16Not applicableCanada
Teva-lamotriginetablet25 mgoralTeva Canada Limited2004-01-16Not applicableCanada
Teva-lamotriginetablet100 mgoralTeva Canada Limited2004-01-16Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lamotriginetablet150 mgoralApotex Inc2002-03-18Not applicableCanada
Apo-lamotriginetablet25 mgoralApotex Inc2002-03-18Not applicableCanada
Apo-lamotriginetablet100 mgoralApotex Inc2002-03-18Not applicableCanada
Lamotriginetablet25 mg/1oralUnit Dose Services2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralREMEDYREPACK INC.2014-03-04Not applicableUs
Lamotriginetablet150 mg/1oralDr.Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release200 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet, chewable25 mg/1oralJubilant Cadista Pharmaceuticals Inc.2011-03-20Not applicableUs
Lamotriginetablet200 mg/1oralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2011-06-08Not applicableUs
Lamotriginetablet, chewable5 mg/1oralCadila Healthcare Limited2009-01-23Not applicableUs
Lamotriginetablet, chewable25 mg/1oralAmerican Health Packaging2011-06-17Not applicableUs
Lamotriginetablet150 mg/1oralUpsher Smith Laboratories, Inc.2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralGlenmark Pharmaceuticals Inc., Usa2012-05-04Not applicableUs
Lamotriginetablet, orally disintegrating25 mg/1oralPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet, film coated, extended release50 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet, orally disintegrating50 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not applicableUs
Lamotriginetablet150 mg/1oralMylan Pharmaceuticals Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralNorth Star Rx Llc2013-01-01Not applicableUs
Lamotriginetablet25 mg/1oralAv Kare, Inc.2013-04-03Not applicableUs
Lamotriginetablet200 mg/1oralREMEDYREPACK INC.2013-05-09Not applicableUs
Lamotriginetablet150 mg/1oralREMEDYREPACK INC.2011-07-29Not applicableUs
Lamotriginetablet200 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lamotriginetablet, extended release200 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet150 mg/1oralHikma Pharmaceutical2011-04-19Not applicableUs
Lamotriginetablet25 mg/1oralProficient Rx LP2011-11-01Not applicableUs
Lamotriginetablet100 mg/1oralTYA Pharmaceuticals2011-11-01Not applicableUs
Lamotriginetablet25 mg/1oralAscend Laboratories, LLC2011-06-22Not applicableUs
LamotriginekitSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet250 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralMc Kesson Contract Packaging2013-05-13Not applicableUs
Lamotriginetablet, for suspension25 mg/1oralAlembic Pharmaceuticals Inc.2014-04-11Not applicableUs
Lamotriginetablet25 mg/1oralTeva Pharmaceuticals USA Inc2008-07-22Not applicableUs
LamotriginekitUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet, extended release50 mg/1oralTorrent Pharmaceuticals Limited2013-12-23Not applicableUs
Lamotriginetablet150 mg/1oralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not applicableUs
Lamotriginetablet100 mg/1oralCipla USA Inc.2010-11-01Not applicableUs
LamotriginekitPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet150 mg/1oralWest ward Pharmaceutical Corp2011-04-19Not applicableUs
Lamotriginetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-07-22Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2011-12-13Not applicableUs
Lamotriginetablet200 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralMylan Institutional Inc.2009-06-19Not applicableUs
Lamotriginetablet, film coated, extended release100 mg/1oralWilshire Pharmaceuticals, Inc.2014-03-17Not applicableUs
Lamotriginetablet, extended release300 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet100 mg/1oralClinical Solutions Wholesale, Llc2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralApotex Corp2009-01-27Not applicableUs
Lamotriginetablet, extended release100 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet150 mg/1oralAurobindo Pharma Limited2009-01-27Not applicableUs
Lamotriginetablet50 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralTorrent Pharmaceuticals Limited2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralAmerican Health Packaging2013-07-05Not applicableUs
Lamotriginetablet200 mg/1oralSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, chewable25 mg/1oralGlenmark Pharmaceuticals Inc., Usa2009-02-19Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2016-03-11Not applicableUs
Lamotriginetablet150 mg/1oralTeva Pharmaceuticals USA Inc2008-07-22Not applicableUs
Lamotriginetablet200 mg/1oralUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet, chewable25 mg/1oralCobalt Laboratories2009-07-29Not applicableUs
Lamotriginetablet200 mg/1oralAidarex Pharmaceuticals LLC2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2013-03-05Not applicableUs
Lamotriginetablet150 mg/1oralAv Pak2015-06-25Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-02-28Not applicableUs
Lamotriginetablet150 mg/1oralPhysicians Total Care, Inc.2012-01-04Not applicableUs
Lamotriginetablet25 mg/1oralCardinal Health2009-12-22Not applicableUs
Lamotriginetablet150 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralbryant ranch prepack2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralAv Kare, Inc.2013-04-03Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-04-22Not applicableUs
Lamotriginetablet25 mg/1oralMylan Institutional Inc.2009-03-02Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2014-05-19Not applicableUs
Lamotriginetablet200 mg/1oralDr.Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release100 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet25 mg/1oralApotex Corp2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralMc Kesson Packaging Sevices A Business Unit Of Mc Kesson Corporation2014-02-05Not applicableUs
Lamotriginetablet, chewable25 mg/1oralCadila Healthcare Limited2009-01-23Not applicableUs
Lamotriginetablet200 mg/1oralAmerican Health Packaging2014-08-28Not applicableUs
Lamotriginetablet200 mg/1oralUpsher Smith Laboratories, Inc.2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralGlenmark Pharmaceuticals Inc., Usa2012-05-04Not applicableUs
Lamotriginetablet, orally disintegrating50 mg/1oralPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet, film coated, extended release200 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet, orally disintegrating100 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not applicableUs
Lamotriginetablet200 mg/1oralMylan Pharmaceuticals Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralNorth Star Rx Llc2013-01-01Not applicableUs
Lamotriginetablet, extended release100 mg/1oralTorrent Pharmaceuticals Limited2013-12-23Not applicableUs
Lamotriginetablet200 mg/1oralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2011-08-23Not applicableUs
Lamotriginetablet, chewable5 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-02-04Not applicableUs
Lamotriginetablet100 mg/1oralPhysicians Total Care, Inc.2008-07-30Not applicableUs
Lamotriginetablet100 mg/1oralCardinal Health2009-09-22Not applicableUs
Lamotriginetablet200 mg/1oralHikma Pharmaceutical2011-04-19Not applicableUs
Lamotriginetablet100 mg/1oralbryant ranch prepack2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralAscend Laboratories, LLC2011-06-22Not applicableUs
Lamotriginetablet25 mg/1oralSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, chewable5 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-23Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2015-12-30Not applicableUs
Lamotriginetablet, chewable25 mg/1oralAvera Mc Kennan Hospital2015-04-16Not applicableUs
Lamotriginetablet, chewable25 mg/1oralTeva Pharmaceuticals USA Inc2006-06-29Not applicableUs
Lamotriginetablet25 mg/1oralUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet200 mg/1oralAurobindo Pharma Limited2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralTorrent Pharmaceuticals Limited2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralCipla USA Inc.2010-11-01Not applicableUs
LamotriginekitPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet100 mg/1oralWest ward Pharmaceutical Corp2011-04-19Not applicableUs
Lamotriginetablet100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-07-22Not applicableUs
Lamotriginetablet200 mg/1oralREMEDYREPACK INC.2013-04-22Not applicableUs
Lamotriginetablet100 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not applicableUs
Lamotriginetablet, film coated, extended release200 mg/1oralWilshire Pharmaceuticals, Inc.2014-03-17Not applicableUs
Lamotriginetablet, extended release25 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet150 mg/1oralClinical Solutions Wholesale2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2015-03-11Not applicableUs
Lamotriginetablet, extended release50 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet25 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-01-20Not applicableUs
Lamotriginetablet200 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralAmerican Health Packaging2013-07-05Not applicableUs
Lamotriginetablet25 mg/1oralUpsher Smith Laboratories, Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralGlenmark Pharmaceuticals Inc., Usa2012-05-04Not applicableUs
Lamotriginetablet, for suspension5 mg/1oralAlembic Pharmaceuticals Limited2016-01-29Not applicableUs
Lamotriginetablet, film coated, extended release25 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet200 mg/1oralTeva Pharmaceuticals USA Inc2008-07-22Not applicableUs
Lamotriginetablet25 mg/1oralMylan Pharmaceuticals Inc.2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralSTAT Rx USA LLC2010-12-07Not applicableUs
Lamotriginetablet100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-09Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-05-10Not applicableUs
Lamotriginetablet200 mg/1oralAv Pak2015-06-25Not applicableUs
Lamotriginetablet150 mg/1oralREMEDYREPACK INC.2013-03-27Not applicableUs
Lamotriginetablet25 mg/1oralDr.Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet100 mg/1oralCardinal Health2009-12-22Not applicableUs
Lamotriginetablet200 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not applicableUs
Lamotriginetablet, chewable5 mg/1oralMylan Pharmaceuticals Inc.2009-01-26Not applicableUs
Lamotriginetablet150 mg/1oralNorth Star Rx Llc2013-01-01Not applicableUs
Lamotriginetablet150 mg/1oralAv Kare, Inc.2013-04-03Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-02-08Not applicableUs
Lamotriginetablet100 mg/1oralMylan Institutional Inc.2009-03-02Not applicableUs
Lamotriginetablet, film coated, extended release25 mg/1oralWilshire Pharmaceuticals, Inc.2014-03-17Not applicableUs
Lamotriginetablet, chewable5 mg/1oralDr. Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release50 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet100 mg/1oralApotex Corp2009-01-27Not applicableUs
Lamotriginetablet, extended release25 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet25 mg/1oralAurobindo Pharma Limited2009-01-27Not applicableUs
Lamotriginetablet, chewable5 mg/1oralCarilion Materials Management2008-08-28Not applicableUs
Lamotriginetablet25 mg/1oralTorrent Pharmaceuticals Limited2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralPreferred Pharmaceuticals, Inc.2014-01-20Not applicableUs
Lamotriginetablet, orally disintegrating100 mg/1oralPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet, film coated, extended release300 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet, orally disintegrating200 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not applicableUs
Lamotriginetablet100 mg/1oralTeva Pharmaceuticals USA Inc2008-07-22Not applicableUs
Lamotriginetablet100 mg/1oralUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet, extended release200 mg/1oralTorrent Pharmaceuticals Limited2013-12-23Not applicableUs
Lamotriginetablet25 mg/1oralAidarex Pharmaceuticals LLC2009-01-27Not applicableUs
Lamotriginetablet, chewable25 mg/1oralREMEDYREPACK INC.2011-09-08Not applicableUs
Lamotriginetablet25 mg/1oralAv Pak2015-06-25Not applicableUs
Lamotriginetablet, chewable25 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-02-04Not applicableUs
Lamotriginetablet200 mg/1oralPhysicians Total Care, Inc.2008-12-05Not applicableUs
Lamotriginetablet25 mg/1oralCardinal Health2012-08-24Not applicableUs
Lamotriginetablet25 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralbryant ranch prepack2009-01-27Not applicableUs
Lamotriginetablet50 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralAscend Laboratories, LLC2011-06-22Not applicableUs
Lamotriginetablet100 mg/1oralSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, chewable25 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-23Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2016-03-04Not applicableUs
Lamotriginetablet200 mg/1oralDIRECT RX2015-01-01Not applicableUs
Lamotriginetablet, extended release300 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet, chewable5 mg/1oralAurobindo Pharma Limited2009-11-04Not applicableUs
Lamotriginetablet150 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
LamotriginekitTorrent Pharmaceuticals Limited2009-09-14Not applicableUs
Lamotriginetablet200 mg/1oralCipla USA Inc.2010-11-01Not applicableUs
LamotriginekitPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet25 mg/1oralWest ward Pharmaceutical Corp2011-04-19Not applicableUs
Lamotriginetablet150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-07-22Not applicableUs
Lamotriginetablet25 mg/1oralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not applicableUs
Lamotriginetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lamotriginetablet, extended release50 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet25 mg/1oralHikma Pharmaceutical2011-04-19Not applicableUs
Lamotriginetablet, extended release25 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet, chewable5 mg/1oralJubilant Cadista Pharmaceuticals Inc.2011-03-20Not applicableUs
Lamotriginetablet100 mg/1oralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2011-06-08Not applicableUs
Lamotriginetablet250 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralAmerican Health Packaging2013-07-05Not applicableUs
Lamotriginetablet100 mg/1oralUpsher Smith Laboratories, Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralGlenmark Pharmaceuticals Inc., Usa2012-05-04Not applicableUs
Lamotriginetablet, for suspension25 mg/1oralAlembic Pharmaceuticals Limited2016-01-29Not applicableUs
Lamotriginetablet, film coated, extended release100 mg/1oralActavis Pharma, Inc.2016-04-01Not applicableUs
Lamotriginetablet, orally disintegrating25 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not applicableUs
Lamotriginetablet100 mg/1oralMylan Pharmaceuticals Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralSTAT Rx USA LLC2010-12-07Not applicableUs
Lamotriginetablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-09Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2013-04-15Not applicableUs
Lamotriginetablet100 mg/1oralUnit Dose Services2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2013-05-07Not applicableUs
Lamotriginetablet100 mg/1oralDr.Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet200 mg/1oralREMEDYREPACK INC.2014-08-25Not applicableUs
Lamotriginetablet200 mg/1oralWest ward Pharmaceutical Corp2011-04-19Not applicableUs
Lamotriginetablet, chewable25 mg/1oralMylan Pharmaceuticals Inc.2009-01-26Not applicableUs
Lamotriginetablet200 mg/1oralNorth Star Rx Llc2013-01-01Not applicableUs
Lamotriginetablet200 mg/1oralAv Kare, Inc.2013-04-03Not applicableUs
Lamotriginetablet25 mg/1oralREMEDYREPACK INC.2013-02-27Not applicableUs
Lamotriginetablet150 mg/1oralMylan Institutional Inc.2009-06-19Not applicableUs
Lamotriginetablet, film coated, extended release50 mg/1oralWilshire Pharmaceuticals, Inc.2014-03-17Not applicableUs
Lamotriginetablet, chewable25 mg/1oralDr. Reddy's Laboratories Limited2009-01-29Not applicableUs
Lamotriginetablet, extended release300 mg/1oralWockhardt Limited2012-11-29Not applicableUs
Lamotriginetablet150 mg/1oralApotex Corp2009-01-27Not applicableUs
Lamotriginetablet, extended release200 mg/1oralWockhardt USA LLC.2012-11-29Not applicableUs
Lamotriginetablet100 mg/1oralAurobindo Pharma Limited2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralTorrent Pharmaceuticals Limited2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralCipla USA Inc.2010-11-01Not applicableUs
Lamotriginetablet, orally disintegrating200 mg/1oralPar Pharmaceutical Inc.2013-06-02Not applicableUs
Lamotriginetablet150 mg/1oralREMEDYREPACK INC.2016-03-11Not applicableUs
Lamotriginetablet, chewable5 mg/1oralTeva Pharmaceuticals USA Inc2006-08-28Not applicableUs
Lamotriginetablet150 mg/1oralUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet, chewable5 mg/1oralCobalt Laboratories2009-07-29Not applicableUs
Lamotriginetablet100 mg/1oralAidarex Pharmaceuticals LLC2011-11-01Not applicableUs
Lamotriginetablet200 mg/1oralREMEDYREPACK INC.2011-08-23Not applicableUs
Lamotriginetablet100 mg/1oralAv Pak2015-06-25Not applicableUs
Lamotriginetablet100 mg/1oralREMEDYREPACK INC.2013-02-22Not applicableUs
Lamotriginetablet25 mg/1oralPhysicians Total Care, Inc.2009-12-09Not applicableUs
Lamotriginetablet100 mg/1oralCardinal Health2012-08-24Not applicableUs
Lamotriginetablet100 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralbryant ranch prepack2009-01-27Not applicableUs
Lamotriginetablet100 mg/1oralCadila Healthcare Limited2009-01-27Not applicableUs
Lamotriginetablet200 mg/1oralAscend Laboratories, LLC2011-06-22Not applicableUs
Lamotriginetablet150 mg/1oralSandoz Inc2010-01-05Not applicableUs
Lamotriginetablet, chewable5 mg/1oralGlenmark Pharmaceuticals Inc., Usa2009-02-19Not applicableUs
Lamotriginetablet, extended release100 mg/1oralDr.Reddy's Laboratories Limited2013-06-20Not applicableUs
Lamotriginetablet100 mg/1oralHikma Pharmaceutical2011-04-19Not applicableUs
Lamotriginetablet100 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lamotriginetablet25 mg/1oralTYA Pharmaceuticals2011-11-01Not applicableUs
Lamotriginetablet, chewable25 mg/1oralAurobindo Pharma Limited2009-11-04Not applicableUs
Lamotriginetablet200 mg/1oralZydus Pharmaceuticals (USA) Inc.2009-01-27Not applicableUs
Lamotriginetablet, extended release25 mg/1oralTorrent Pharmaceuticals Limited2013-12-23Not applicableUs
Lamotriginetablet25 mg/1oralMc Kesson Contract Packaging2011-11-30Not applicableUs
Lamotriginetablet, for suspension5 mg/1oralAlembic Pharmaceuticals Inc.2014-04-11Not applicableUs
LamotriginekitUpsher Smith Laboratories, Inc.2011-02-28Not applicableUs
Lamotriginetablet200 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-07-22Not applicableUs
Lamotriginetablet100 mg/1oralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not applicableUs
Lamotriginetablet150 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-27Not applicableUs
Lamotriginetablet150 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not applicableUs
Lamotriginetablet25 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lamotrigine Extended Releasetablet250 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet25 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet300 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet50 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet100 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Lamotrigine Extended Releasetablet200 mg/1oralPar Pharmaceutical Inc.2013-01-18Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ConvulsanActavis
CrisometJuste
DafexPhoenix
DaksolPharmavita
DanoptinPliva
DezepilRafarm
ElmendosGlaxoSmithKline
EpilepaxIvax
EpimilIvax
EpiralZentiva
EpitecCipla Medpro
EpitrigineActavis
LabilenoGlaxoSmithKline
LambipolGlaxoSmithKline
LamectPharmaSwiss
LameptilSandoz
Lameptil SSandoz
LametecVitalchem
LamezIntas
Lamictal CDGlaxoSmithKline
LamictinGlaxoSmithKline
LamotrixGlenmark
LarigRowex
MedotriginMedochemie
MogineDouglas
TrimolepPsicofarma
TrogineRanbaxy
XebarinDr Reddys
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIU3H27498KS
CAS number84057-84-1
WeightAverage: 256.091
Monoisotopic: 255.007850663
Chemical FormulaC9H7Cl2N5
InChI KeyInChIKey=PYZRQGJRPPTADH-UHFFFAOYSA-N
InChI
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
IUPAC Name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
SMILES
NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassHalobenzenes
Direct ParentDichlorobenzenes
Alternative Parents
Substituents
  • 1,2-dichlorobenzene
  • Aminotriazine
  • 1,2,4-triazine
  • Imidolactam
  • Triazine
  • Primary aromatic amine
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Primary amine
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.
PharmacodynamicsLamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is also used in the treatment of depression and bipolar disorder. Lamotrigine is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Lamotrigine inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate.
Mechanism of actionOne proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. in vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels and/or calcium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate). Studies on lamotrigine show binding to sodium channels similar to local anesthetics.
Related Articles
Absorption98%
Volume of distribution
  • 0.9 to 1.3 L/kg
Protein binding55%
Metabolism

Hepatic

SubstrateEnzymesProduct
Lamotrigine
lamotrigine-2-N-glucuronideDetails
Route of eliminationNot Available
Half life25 +/- 10 hours (healthy individuals); 42.9 hours (chronic renal failure)
Clearance
  • Apparent plasma cl=0.44 mL/min/kg [healthy volunteers taking single-dose LAMICTAL]
  • Apparent plasma cl=0.58 mL/min/kg [healthy volunteers taking multiple-dose LAMICTAL]
  • Apparent plasma cl=0.30 mL/min/kg [healthy volunteers taking valproate and single-dose LAMICTAL]
  • Apparent plasma cl=0.18 mL/min/kg [healthy volunteers taking valproate and multiple-dose LAMICTAL]
  • Apparent plasma cl=1.1 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and single-dose LAMICTAL]
  • Apparent plasma cl=1.12 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and multiple-dose LAMICTAL]
ToxicityLD50=250 (mg/kg) (in rat, mice); LD50>640 orally (mg/kg) (in rat, mice) (Sawyer). Symptoms of overdose include decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, and rolling eyeballs.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9382
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.7155
P-glycoprotein inhibitor INon-inhibitor0.911
P-glycoprotein inhibitor IINon-inhibitor0.9604
Renal organic cation transporterNon-inhibitor0.8176
CYP450 2C9 substrateNon-substrate0.9162
CYP450 2D6 substrateNon-substrate0.9055
CYP450 3A4 substrateNon-substrate0.6862
CYP450 1A2 substrateNon-inhibitor0.611
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.7007
CYP450 2C19 inhibitorNon-inhibitor0.8594
CYP450 3A4 inhibitorNon-inhibitor0.7678
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5515
Ames testNon AMES toxic0.8202
CarcinogenicityNon-carcinogens0.7895
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.7556 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9168
hERG inhibition (predictor II)Non-inhibitor0.8735
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Glaxosmithkline
  • Aurobindo pharma ltd
  • Dr reddys laboratories ltd
  • Glenmark generics ltd
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Taro pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Zydus pharmaceuticals usa inc
  • Smithkline beecham corp
  • Smithkline beecham corp dba glaxosmithkline
  • Apotex inc
  • Cadista pharmaceuticals inc
  • Lupin ltd
  • Matrix laboratories ltd
  • Roxane laboratories inc
  • Torrent pharmaceuticals ltd
  • Upsher smith laboratories inc
  • Wockhardt ltd
Packagers
Dosage forms
FormRouteStrength
Kit
Tabletoral100 mg
Tabletoral150 mg
Tabletoral2 mg
Tabletoral25 mg
Tabletoral5 mg
Tablet, chewableoral2 mg/1
Tabletoral200 mg
Tablet, film coated, extended releaseoral100 mg/1
Tablet, film coated, extended releaseoral200 mg/1
Tablet, film coated, extended releaseoral25 mg/1
Tablet, film coated, extended releaseoral250 mg/1
Tablet, film coated, extended releaseoral300 mg/1
Tablet, film coated, extended releaseoral50 mg/1
Tabletoral100 mg/1
Tabletoral150 mg/1
Tabletoral200 mg/1
Tabletoral25 mg/1
Tablet, chewableoral25 mg/1
Tablet, chewableoral5 mg/1
Tablet, extended releaseoral100 mg/1
Tablet, extended releaseoral200 mg/1
Tablet, extended releaseoral25 mg/1
Tablet, extended releaseoral300 mg/1
Tablet, extended releaseoral50 mg/1
Tablet, for suspensionoral25 mg/1
Tablet, for suspensionoral5 mg/1
Tablet, orally disintegratingoral100 mg/1
Tablet, orally disintegratingoral200 mg/1
Tablet, orally disintegratingoral25 mg/1
Tablet, orally disintegratingoral50 mg/1
Tabletoral250 mg/1
Tabletoral300 mg/1
Tabletoral50 mg/1
Prices
Unit descriptionCostUnit
LaMICtal Starter 98 25 (84)-100(14)mg Kit Box556.69USD box
LaMICtal XR 200 mg 24 Hour tablet12.11USD tablet
Lamictal xr 200 mg tablet11.65USD tablet
LaMICtal XR 100 mg 24 Hour tablet11.36USD tablet
Lamictal xr 100 mg tablet10.92USD tablet
Lamictal xr 50 mg tablet10.2USD tablet
Lamictal 200 mg tablet7.44USD tablet
Lamictal odt start kt (orange)7.28USD tablet
Lamictal xr start kit (orange)7.28USD tablet
Lamictal odt 200 mg tablet6.95USD tablet
Lamictal odt 100 mg tablet5.82USD tablet
Lamotrigine 200 mg tablet5.78USD tablet
LaMICtal 25 mg Chew Tabs5.63USD tab
Lamictal odt 50 mg tablet5.46USD tablet
Lamictal tab start kit (green)5.46USD tablet
Lamictal 150 mg tablet5.38USD tablet
Lamictal odt 25 mg tablet5.1USD tablet
Lamictal xr 25 mg tablet5.1USD tablet
Lamictal 100 mg tablet4.72USD tablet
Lamotrigine tablet starter kit4.24USD tablet
Lamotrigine 150 mg tablet3.98USD tablet
Lamictal 25 mg tablet3.78USD tablet
Lamotrigine 100 mg tablet3.52USD tablet
LamoTRIgine 25 mg Chew Tabs3.33USD tab
LamoTRIgine 5 mg Chew Tabs3.18USD tab
Lamotrigine 25 mg tablet2.9USD tablet
Apo-Lamotrigine 150 mg Tablet1.31USD tablet
Mylan-Lamotrigine 150 mg Tablet1.31USD tablet
Novo-Lamotrigine 150 mg Tablet1.31USD tablet
Pms-Lamotrigine 150 mg Tablet1.31USD tablet
Ratio-Lamotrigine 150 mg Tablet1.31USD tablet
Apo-Lamotrigine 100 mg Tablet0.88USD tablet
Mylan-Lamotrigine 100 mg Tablet0.88USD tablet
Novo-Lamotrigine 100 mg Tablet0.88USD tablet
Pms-Lamotrigine 100 mg Tablet0.88USD tablet
Ratio-Lamotrigine 100 mg Tablet0.88USD tablet
Apo-Lamotrigine 25 mg Tablet0.22USD tablet
Mylan-Lamotrigine 25 mg Tablet0.22USD tablet
Novo-Lamotrigine 25 mg Tablet0.22USD tablet
Pms-Lamotrigine 25 mg Tablet0.22USD tablet
Ratio-Lamotrigine 25 mg Tablet0.22USD tablet
Lamictal 5 mg Chewable Tablet0.18USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2277722 No2001-03-272012-01-29Canada
US5698226 No1995-07-292012-07-29Us
US7919115 No2009-01-042029-01-04Us
US8637512 No2008-06-142028-06-14Us
US8840925 No2008-07-022028-07-02Us
US9144547 No2003-09-222023-09-22Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point216-218 °C (uncorr)Not Available
logP2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.488 mg/mLALOGPS
logP1.87ALOGPS
logP1.93ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)14.98ChemAxon
pKa (Strongest Basic)5.87ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area90.71 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity66.62 m3·mol-1ChemAxon
Polarizability23.1 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Grahame Roy Lee, “Process for the preparation of lamotrigine.” U.S. Patent US5925755, issued January, 1981.

US5925755
General References
  1. Backonja M: Neuromodulating drugs for the symptomatic treatment of neuropathic pain. Curr Pain Headache Rep. 2004 Jun;8(3):212-6. [PubMed:15115640 ]
  2. Barbosa L, Berk M, Vorster M: A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J Clin Psychiatry. 2003 Apr;64(4):403-7. [PubMed:12716240 ]
  3. Jensen TS: Anticonvulsants in neuropathic pain: rationale and clinical evidence. Eur J Pain. 2002;6 Suppl A:61-8. [PubMed:11888243 ]
  4. Pappagallo M: Newer antiepileptic drugs: possible uses in the treatment of neuropathic pain and migraine. Clin Ther. 2003 Oct;25(10):2506-38. [PubMed:14667954 ]
  5. Tehrani SP, Daryaafzoon M, Bakhtiarian A, Ejtemaeemehr S, Sahraei H: The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9. [PubMed:19579915 ]
External Links
ATC CodesN03AX09
AHFS Codes
  • 28:12.92
PDB EntriesNot Available
FDA labelDownload (3.15 MB)
MSDSDownload (28.6 KB)
Interactions
Drug Interactions
Drug
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Lamotrigine.
2-mercaptobenzothiazoleThe risk or severity of adverse effects can be increased when 2-mercaptobenzothiazole is combined with Lamotrigine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Lamotrigine.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Lamotrigine.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Lamotrigine.
AcetaminophenThe serum concentration of Lamotrigine can be increased when it is combined with Acetaminophen.
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Lamotrigine.
AfatinibThe serum concentration of Lamotrigine can be increased when it is combined with Afatinib.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Lamotrigine.
AlbendazoleThe serum concentration of Lamotrigine can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Lamotrigine can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Lamotrigine can be increased when it is combined with Alectinib.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Lamotrigine.
AlfentanilThe serum concentration of Lamotrigine can be increased when it is combined with Alfentanil.
AlfentanilThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Alfentanil.
AlfuzosinAlfuzosin may increase the hypotensive activities of Lamotrigine.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Lamotrigine.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Lamotrigine.
AmantadineThe serum concentration of Lamotrigine can be increased when it is combined with Amantadine.
Aminohippuric acidThe serum concentration of Lamotrigine can be increased when it is combined with Aminohippuric acid.
AmiodaroneThe serum concentration of Lamotrigine can be decreased when it is combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Lamotrigine.
AmitriptylineThe serum concentration of Lamotrigine can be increased when it is combined with Amitriptyline.
AmitriptylineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Amitriptyline.
AmlodipineThe serum concentration of Lamotrigine can be increased when it is combined with Amlodipine.
AmobarbitalThe metabolism of Lamotrigine can be increased when combined with Amobarbital.
AmobarbitalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Amobarbital.
AmorolfineThe risk or severity of adverse effects can be increased when Amorolfine is combined with Lamotrigine.
AmoxapineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Lamotrigine.
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Lamotrigine.
AmprenavirThe serum concentration of Lamotrigine can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Lamotrigine can be increased when it is combined with Amsacrine.
AN2690The risk or severity of adverse effects can be increased when AN2690 is combined with Lamotrigine.
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Lamotrigine.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Lamotrigine.
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Lamotrigine.
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Lamotrigine.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Lamotrigine.
AstemizoleThe serum concentration of Lamotrigine can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Lamotrigine can be decreased when it is combined with Atazanavir.
AtenololThe serum concentration of Lamotrigine can be increased when it is combined with Atenolol.
AtorvastatinThe serum concentration of Lamotrigine can be increased when it is combined with Atorvastatin.
AtosibanThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Atosiban.
Atracurium besylateLamotrigine may increase the neuromuscular blocking activities of Atracurium besylate.
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Lamotrigine.
AzelastineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe serum concentration of Lamotrigine can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Lamotrigine can be increased when it is combined with Azithromycin.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Lamotrigine.
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Lamotrigine.
BarbitalThe metabolism of Lamotrigine can be increased when combined with Barbital.
BarbitalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Barbital.
BenzocaineThe serum concentration of Lamotrigine can be increased when it is combined with Benzocaine.
BenzocaineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Benzocaine.
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Lamotrigine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Lamotrigine.
BepridilThe serum concentration of Lamotrigine can be increased when it is combined with Bepridil.
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Lamotrigine.
BiperidenThe serum concentration of Lamotrigine can be increased when it is combined with Biperiden.
BosutinibThe serum concentration of Lamotrigine can be increased when it is combined with Bosutinib.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
BrimonidineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Lamotrigine.
BromocriptineThe serum concentration of Lamotrigine can be increased when it is combined with Bromocriptine.
BrompheniramineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Lamotrigine.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lamotrigine.
BuprenorphineThe serum concentration of Lamotrigine can be increased when it is combined with Buprenorphine.
BuprenorphineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Buprenorphine.
BuspironeThe serum concentration of Lamotrigine can be increased when it is combined with Buspirone.
BuspironeThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Buspirone.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Lamotrigine.
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Lamotrigine.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Lamotrigine.
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Lamotrigine.
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Lamotrigine.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Lamotrigine.
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Lamotrigine.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Lamotrigine.
CabazitaxelThe serum concentration of Lamotrigine can be increased when it is combined with Cabazitaxel.
CaffeineThe serum concentration of Lamotrigine can be increased when it is combined with Caffeine.
CanagliflozinThe serum concentration of Lamotrigine can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Lamotrigine can be increased when it is combined with Candesartan.
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Lamotrigine.
CaptoprilThe serum concentration of Lamotrigine can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Lamotrigine can be decreased when it is combined with Carbamazepine.
CarbamazepineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Carbamazepine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lamotrigine.
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Lamotrigine.
CarvedilolCarvedilol may increase the hypotensive activities of Lamotrigine.
CaspofunginThe serum concentration of Lamotrigine can be increased when it is combined with Caspofungin.
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Lamotrigine.
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Lamotrigine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lamotrigine.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lamotrigine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Lamotrigine.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Lamotrigine.
ChloroquineThe serum concentration of Lamotrigine can be increased when it is combined with Chloroquine.
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Lamotrigine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Chlorphenamine.
ChlorpromazineThe serum concentration of Lamotrigine can be increased when it is combined with Chlorpromazine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Lamotrigine can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Lamotrigine can be increased when it is combined with Chlorprothixene.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Lamotrigine.
CholesterolThe serum concentration of Lamotrigine can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Lamotrigine can be decreased when it is combined with Cholic Acid.
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Lamotrigine.
CilazaprilThe serum concentration of Lamotrigine can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Lamotrigine can be decreased when it is combined with Cimetidine.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Lamotrigine.
CiprofloxacinThe serum concentration of Lamotrigine can be increased when it is combined with Ciprofloxacin.
CitalopramThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Citalopram.
CitalopramThe serum concentration of Lamotrigine can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Lamotrigine can be increased when it is combined with Clarithromycin.
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Lamotrigine.
ClidiniumThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Lamotrigine.
ClofazimineThe serum concentration of Lamotrigine can be increased when it is combined with Clofazimine.
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Lamotrigine.
ClomipramineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Clomipramine.
ClomipramineThe serum concentration of Lamotrigine can be increased when it is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Clonidine.
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Lamotrigine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Lamotrigine.
ClotrimazoleThe serum concentration of Lamotrigine can be decreased when it is combined with Clotrimazole.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Lamotrigine.
CobicistatThe serum concentration of Lamotrigine can be increased when it is combined with Cobicistat.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Lamotrigine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Lamotrigine.
ColchicineThe serum concentration of Lamotrigine can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Lamotrigine can be increased when it is combined with Colforsin.
CrizotinibThe serum concentration of Lamotrigine can be increased when it is combined with Crizotinib.
CyclizineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Lamotrigine.
CyclophosphamideThe serum concentration of Lamotrigine can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Lamotrigine can be decreased when it is combined with Cyclosporine.
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Lamotrigine.
DaclatasvirThe serum concentration of Lamotrigine can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Lamotrigine can be increased when it is combined with Dactinomycin.
DantroleneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Lamotrigine.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Lamotrigine.
DapoxetineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Dapoxetine.
DasatinibThe serum concentration of Lamotrigine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Lamotrigine can be decreased when it is combined with Daunorubicin.
Decanoic AcidThe risk or severity of adverse effects can be increased when Decanoic Acid is combined with Lamotrigine.
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Lamotrigine.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Lamotrigine.
DesipramineThe serum concentration of Lamotrigine can be increased when it is combined with Desipramine.
DesipramineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Desipramine.
DesloratadineThe serum concentration of Lamotrigine can be increased when it is combined with Desloratadine.
DesloratadineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Desloratadine.
DesmopressinThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Desmopressin.
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Lamotrigine.
DexamethasoneThe serum concentration of Lamotrigine can be decreased when it is combined with Dexamethasone.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Lamotrigine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Lamotrigine.
DextromethorphanThe serum concentration of Lamotrigine can be increased when it is combined with Dextromethorphan.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Lamotrigine.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Lamotrigine.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Lamotrigine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Lamotrigine.
DiclofenacThe serum concentration of Lamotrigine can be increased when it is combined with Diclofenac.
DifenoxinThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Difenoxin.
DigoxinThe serum concentration of Lamotrigine can be decreased when it is combined with Digoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Lamotrigine.
DihydroergotamineThe serum concentration of Lamotrigine can be increased when it is combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Lamotrigine.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Lamotrigine.
DiltiazemThe serum concentration of Lamotrigine can be increased when it is combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lamotrigine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Lamotrigine.
DipyridamoleThe serum concentration of Lamotrigine can be increased when it is combined with Dipyridamole.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Lamotrigine.
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Lamotrigine.
DoxazosinDoxazosin may increase the hypotensive activities of Lamotrigine.
DoxepinThe serum concentration of Lamotrigine can be increased when it is combined with Doxepin.
DoxepinThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Doxepin.
DoxorubicinThe serum concentration of Lamotrigine can be decreased when it is combined with Doxorubicin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
DoxylamineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Lamotrigine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
DronedaroneThe serum concentration of Lamotrigine can be increased when it is combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Lamotrigine.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Lamotrigine.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Lamotrigine.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Lamotrigine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Lamotrigine.
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Lamotrigine.
EfavirenzThe serum concentration of Lamotrigine can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Efavirenz.
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Lamotrigine.
ElbasvirThe serum concentration of Lamotrigine can be increased when it is combined with Elbasvir.
EnalaprilThe serum concentration of Lamotrigine can be increased when it is combined with Enalapril.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Lamotrigine.
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Lamotrigine.
EnzalutamideThe serum concentration of Lamotrigine can be increased when it is combined with Enzalutamide.
ErgonovineThe serum concentration of Lamotrigine can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Lamotrigine can be increased when it is combined with Ergotamine.
ErythromycinThe serum concentration of Lamotrigine can be decreased when it is combined with Erythromycin.
EscitalopramThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Lamotrigine.
EstramustineThe serum concentration of Lamotrigine can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Lamotrigine can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Lamotrigine can be decreased when it is combined with Estrone.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Lamotrigine.
EthanolLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Lamotrigine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Lamotrigine.
EthosuximideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Lamotrigine.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Lamotrigine.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Lamotrigine.
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Lamotrigine.
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Lamotrigine.
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Lamotrigine.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Lamotrigine.
EtoperidoneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Etoperidone.
EtoposideThe serum concentration of Lamotrigine can be increased when it is combined with Etoposide.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Lamotrigine.
EtravirineThe serum concentration of Lamotrigine can be increased when it is combined with Etravirine.
EzogabineThe serum concentration of Lamotrigine can be decreased when it is combined with Ezogabine.
EzogabineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Felbamate.
FelodipineThe serum concentration of Lamotrigine can be increased when it is combined with Felodipine.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Lamotrigine.
FenfluramineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fenfluramine.
FentanylThe serum concentration of Lamotrigine can be increased when it is combined with Fentanyl.
FentanylThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fentanyl.
FexofenadineThe serum concentration of Lamotrigine can be increased when it is combined with Fexofenadine.
FexofenadineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fexofenadine.
FidaxomicinThe serum concentration of Lamotrigine can be increased when it is combined with Fidaxomicin.
FlibanserinThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Flibanserin.
FluconazoleThe serum concentration of Lamotrigine can be increased when it is combined with Fluconazole.
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Lamotrigine.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Lamotrigine.
FlunarizineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Lamotrigine.
FluoxetineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fluoxetine.
FluoxetineThe serum concentration of Lamotrigine can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Lamotrigine can be increased when it is combined with Flupentixol.
FlupentixolThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Flupentixol.
FluphenazineThe serum concentration of Lamotrigine can be increased when it is combined with Fluphenazine.
FluphenazineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fluphenazine.
FlurazepamThe serum concentration of Lamotrigine can be increased when it is combined with Flurazepam.
FlurazepamThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Lamotrigine.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fluvoxamine.
FluvoxamineThe serum concentration of Lamotrigine can be increased when it is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Lamotrigine.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Lamotrigine.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Lamotrigine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Lamotrigine.
GefitinibThe serum concentration of Lamotrigine can be increased when it is combined with Gefitinib.
GenisteinThe serum concentration of Lamotrigine can be increased when it is combined with Genistein.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lamotrigine.
GlyburideThe serum concentration of Lamotrigine can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Lamotrigine can be increased when it is combined with Glycerol.
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Lamotrigine.
Gramicidin DThe serum concentration of Lamotrigine can be increased when it is combined with Gramicidin D.
GrepafloxacinThe serum concentration of Lamotrigine can be increased when it is combined with Grepafloxacin.
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Lamotrigine.
GuanfacineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Lamotrigine.
HaloperidolThe serum concentration of Lamotrigine can be increased when it is combined with Haloperidol.
HaloperidolThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Haloperidol.
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Lamotrigine.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Lamotrigine.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Lamotrigine.
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Lamotrigine.
HexobarbitalThe metabolism of Lamotrigine can be increased when combined with Hexobarbital.
HexobarbitalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Hexobarbital.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Lamotrigine.
HydrocortisoneThe serum concentration of Lamotrigine can be increased when it is combined with Hydrocortisone.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Lamotrigine.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
HydroxyzineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Hydroxyzine.
IdelalisibThe serum concentration of Lamotrigine can be increased when it is combined with Idelalisib.
IloperidoneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Iloperidone.
ImatinibThe serum concentration of Lamotrigine can be increased when it is combined with Imatinib.
ImipramineThe serum concentration of Lamotrigine can be increased when it is combined with Imipramine.
ImipramineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Indalpine.
IndinavirThe serum concentration of Lamotrigine can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Lamotrigine can be increased when it is combined with Indomethacin.
IndoraminIndoramin may increase the hypotensive activities of Lamotrigine.
IsavuconazoniumThe serum concentration of Lamotrigine can be increased when it is combined with Isavuconazonium.
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Lamotrigine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Lamotrigine.
ItraconazoleThe serum concentration of Lamotrigine can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Lamotrigine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Lamotrigine can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Lamotrigine can be increased when it is combined with Ketamine.
KetamineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Lamotrigine.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Lamotrigine.
KetoconazoleThe serum concentration of Lamotrigine can be increased when it is combined with Ketoconazole.
LabetalolLabetalol may increase the hypotensive activities of Lamotrigine.
LansoprazoleThe serum concentration of Lamotrigine can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Lamotrigine can be increased when it is combined with Lapatinib.
LevetiracetamThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Lamotrigine.
LevocabastineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Levodopa.
LevofloxacinThe serum concentration of Lamotrigine can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Lamotrigine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Lamotrigine.
LevothyroxineThe serum concentration of Lamotrigine can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Lamotrigine can be increased when it is combined with Lidocaine.
LidocaineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Lidocaine.
LiothyronineThe serum concentration of Lamotrigine can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Lamotrigine can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Lamotrigine can be increased when it is combined with Lisinopril.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Lamotrigine.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Lamotrigine.
LomitapideThe serum concentration of Lamotrigine can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Lamotrigine can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Lamotrigine can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Lamotrigine can be increased when it is combined with Loratadine.
LoratadineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lamotrigine.
LosartanThe serum concentration of Lamotrigine can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Lamotrigine can be increased when it is combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Lamotrigine.
Lu AA21004The risk or severity of adverse effects can be increased when Lamotrigine is combined with Lu AA21004.
LumacaftorThe serum concentration of Lamotrigine can be decreased when it is combined with Lumacaftor.
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Lamotrigine.
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium hydroxide.
Magnesium oxideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium oxide.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium salicylate.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Magnesium Sulfate.
MaprotilineThe serum concentration of Lamotrigine can be increased when it is combined with Maprotiline.
MaprotilineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Maprotiline.
MebendazoleThe serum concentration of Lamotrigine can be increased when it is combined with Mebendazole.
MeclizineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Lamotrigine.
MefloquineThe serum concentration of Lamotrigine can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Lamotrigine can be increased when it is combined with Megestrol acetate.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Lamotrigine.
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Lamotrigine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Lamotrigine.
MeprobamateThe serum concentration of Lamotrigine can be increased when it is combined with Meprobamate.
MeprobamateThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Meprobamate.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Lamotrigine.
MetaxaloneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Metaxalone.
MetforminThe serum concentration of Metformin can be increased when it is combined with Lamotrigine.
MethadoneThe serum concentration of Lamotrigine can be increased when it is combined with Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Methadone.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Lamotrigine.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Lamotrigine.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Lamotrigine.
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Lamotrigine.
MethohexitalThe metabolism of Lamotrigine can be increased when combined with Methohexital.
MethohexitalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Methohexital.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Lamotrigine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Lamotrigine.
MethsuximideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Methsuximide.
MethylphenobarbitalThe metabolism of Lamotrigine can be increased when combined with Methylphenobarbital.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Methylphenobarbital.
MetoprololThe serum concentration of Lamotrigine can be increased when it is combined with Metoprolol.
MetyrosineLamotrigine may increase the sedative activities of Metyrosine.
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Lamotrigine.
MianserinThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Mianserin.
MibefradilThe serum concentration of Lamotrigine can be increased when it is combined with Mibefradil.
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Lamotrigine.
MiconazoleThe serum concentration of Lamotrigine can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Lamotrigine can be decreased when it is combined with Midazolam.
MidazolamThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Midazolam.
MifepristoneThe serum concentration of Lamotrigine can be decreased when it is combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Milnacipran.
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Lamotrigine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
MirtazapineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Lamotrigine.
MitomycinThe serum concentration of Lamotrigine can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Lamotrigine can be decreased when it is combined with Mitoxantrone.
MivacuriumLamotrigine may increase the neuromuscular blocking activities of Mivacurium.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Lamotrigine.
MonensinThe risk or severity of adverse effects can be increased when Monensin is combined with Lamotrigine.
MorphineThe serum concentration of Lamotrigine can be increased when it is combined with Morphine.
MorphineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Morphine.
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Lamotrigine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
NabiloneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Nabilone.
NafcillinThe metabolism of Lamotrigine can be increased when combined with Nafcillin.
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Lamotrigine.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Lamotrigine.
NaltrexoneThe serum concentration of Lamotrigine can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Lamotrigine can be increased when it is combined with Naringenin.
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Lamotrigine.
NefazodoneThe serum concentration of Lamotrigine can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Lamotrigine can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Lamotrigine can be increased when it is combined with Neostigmine.
NicardipineThe serum concentration of Lamotrigine can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Lamotrigine can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Lamotrigine can be increased when it is combined with Nilotinib.
NisoldipineThe serum concentration of Lamotrigine can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Lamotrigine can be increased when it is combined with Nitrazepam.
NitrazepamThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Nitrazepam.
NitrendipineThe serum concentration of Lamotrigine can be increased when it is combined with Nitrendipine.
NitroprussideLamotrigine may increase the hypotensive activities of Nitroprusside.
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lamotrigine.
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Lamotrigine.
NorethisteroneThe serum concentration of Lamotrigine can be decreased when it is combined with Norethisterone.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Lamotrigine.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Lamotrigine.
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Lamotrigine.
OlanzapineLamotrigine may increase the sedative activities of Olanzapine.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Lamotrigine.
OlopatadineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Olopatadine.
OmeprazoleThe serum concentration of Lamotrigine can be increased when it is combined with Omeprazole.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Lamotrigine.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Lamotrigine.
OrlistatThe serum concentration of Lamotrigine can be decreased when it is combined with Orlistat.
OrphenadrineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Lamotrigine.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Lamotrigine.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Lamotrigine.
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Lamotrigine.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Lamotrigine.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Lamotrigine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Lamotrigine.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Lamotrigine.
P-NitrophenolThe serum concentration of Lamotrigine can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Lamotrigine can be increased when it is combined with Paclitaxel.
pafuramidineThe risk or severity of adverse effects can be increased when pafuramidine is combined with Lamotrigine.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Lamotrigine.
Palmitic AcidThe serum concentration of Lamotrigine can be increased when it is combined with Palmitic Acid.
PantoprazoleThe serum concentration of Lamotrigine can be increased when it is combined with Pantoprazole.
ParaldehydeLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Lamotrigine.
ParoxetineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Paroxetine.
ParoxetineThe serum concentration of Lamotrigine can be increased when it is combined with Paroxetine.
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Lamotrigine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Lamotrigine.
PentobarbitalThe metabolism of Lamotrigine can be increased when combined with Pentobarbital.
PentobarbitalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Pentobarbital.
PerampanelThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Perampanel.
PerindoprilThe serum concentration of Lamotrigine can be increased when it is combined with Perindopril.
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Lamotrigine.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Lamotrigine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Lamotrigine.
PhenobarbitalThe metabolism of Lamotrigine can be increased when combined with Phenobarbital.
PhenobarbitalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Phenobarbital.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Lamotrigine.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Lamotrigine.
PimozideThe serum concentration of Lamotrigine can be increased when it is combined with Pimozide.
PimozideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Pimozide.
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Lamotrigine.
PipotiazineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Pizotifen.
Platelet Activating FactorThe serum concentration of Lamotrigine can be decreased when it is combined with Platelet Activating Factor.
PomalidomideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Pomalidomide.
PonatinibThe serum concentration of Lamotrigine can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Lamotrigine can be increased when it is combined with Posaconazole.
PramipexoleLamotrigine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Lamotrigine.
PravastatinThe serum concentration of Lamotrigine can be increased when it is combined with Pravastatin.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Lamotrigine.
PrazosinPrazosin may increase the hypotensive activities of Lamotrigine.
PrednisoneThe serum concentration of Lamotrigine can be increased when it is combined with Prednisone.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lamotrigine.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Lamotrigine.
PrimidoneThe metabolism of Lamotrigine can be increased when combined with Primidone.
PrimidoneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Primidone.
ProbenecidThe serum concentration of Lamotrigine can be increased when it is combined with Probenecid.
ProcainamideThe serum concentration of Procainamide can be increased when it is combined with Lamotrigine.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Lamotrigine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Lamotrigine.
ProgesteroneThe serum concentration of Lamotrigine can be decreased when it is combined with Progesterone.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Lamotrigine.
PromethazineThe serum concentration of Lamotrigine can be increased when it is combined with Promethazine.
PromethazineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Promethazine.
PropafenoneThe serum concentration of Lamotrigine can be increased when it is combined with Propafenone.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Lamotrigine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Lamotrigine.
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Lamotrigine.
PropranololThe serum concentration of Lamotrigine can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Lamotrigine can be increased when it is combined with Protriptyline.
ProtriptylineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Lamotrigine.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Lamotrigine.
QuercetinThe serum concentration of Lamotrigine can be increased when it is combined with Quercetin.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Lamotrigine.
QuinacrineThe serum concentration of Lamotrigine can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Lamotrigine can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Lamotrigine can be increased when it is combined with Quinine.
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Lamotrigine.
RamelteonThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Ramelteon.
RanitidineThe serum concentration of Lamotrigine can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Lamotrigine can be increased when it is combined with Ranolazine.
RapacuroniumLamotrigine may increase the neuromuscular blocking activities of Rapacuronium.
ReboxetineThe serum concentration of Lamotrigine can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Lamotrigine can be increased when it is combined with Regorafenib.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Lamotrigine.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Lamotrigine.
ReserpineThe serum concentration of Lamotrigine can be decreased when it is combined with Reserpine.
ReserpineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Reserpine.
RifampicinThe metabolism of Lamotrigine can be increased when combined with Rifampicin.
RilpivirineThe serum concentration of Lamotrigine can be increased when it is combined with Rilpivirine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Lamotrigine.
RitonavirThe serum concentration of Lamotrigine can be decreased when it is combined with Ritonavir.
RolapitantThe serum concentration of Lamotrigine can be increased when it is combined with Rolapitant.
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Lamotrigine.
RopiniroleLamotrigine may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Lamotrigine.
RotigotineLamotrigine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Lamotrigine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Lamotrigine.
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Lamotrigine.
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Lamotrigine.
SaquinavirThe serum concentration of Lamotrigine can be decreased when it is combined with Saquinavir.
ScopolamineThe serum concentration of Lamotrigine can be increased when it is combined with Scopolamine.
ScopolamineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Scopolamine.
SecobarbitalThe metabolism of Lamotrigine can be increased when combined with Secobarbital.
SecobarbitalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Secobarbital.
SelegilineThe serum concentration of Lamotrigine can be increased when it is combined with Selegiline.
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Lamotrigine.
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Lamotrigine.
SertralineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Sertraline.
SertralineThe serum concentration of Lamotrigine can be increased when it is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Lamotrigine.
SilodosinSilodosin may increase the hypotensive activities of Lamotrigine.
SimeprevirThe serum concentration of Lamotrigine can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Lamotrigine can be increased when it is combined with Simvastatin.
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Lamotrigine.
SirolimusThe serum concentration of Lamotrigine can be decreased when it is combined with Sirolimus.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Lamotrigine.
SorafenibThe serum concentration of Lamotrigine can be increased when it is combined with Sorafenib.
SpironolactoneThe serum concentration of Lamotrigine can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Lamotrigine can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Lamotrigine can be increased when it is combined with Staurosporine.
StiripentolThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Stiripentol.
StreptozocinThe serum concentration of Lamotrigine can be decreased when it is combined with Streptozocin.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Lamotrigine.
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Lamotrigine.
SulfinpyrazoneThe serum concentration of Lamotrigine can be increased when it is combined with Sulfinpyrazone.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Lamotrigine.
SumatriptanThe serum concentration of Lamotrigine can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Lamotrigine can be increased when it is combined with Sunitinib.
SuvorexantThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Suvorexant.
TacrineThe serum concentration of Lamotrigine can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Lamotrigine can be decreased when it is combined with Tacrolimus.
TamoxifenThe serum concentration of Lamotrigine can be decreased when it is combined with Tamoxifen.
TamsulosinTamsulosin may increase the hypotensive activities of Lamotrigine.
TapentadolThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Tasimelteon.
Taurocholic AcidThe serum concentration of Lamotrigine can be increased when it is combined with Taurocholic Acid.
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Lamotrigine.
TelmisartanThe serum concentration of Lamotrigine can be increased when it is combined with Telmisartan.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Lamotrigine.
TemsirolimusThe serum concentration of Lamotrigine can be increased when it is combined with Temsirolimus.
TerazosinTerazosin may increase the hypotensive activities of Lamotrigine.
TerbinafineThe risk or severity of adverse effects can be increased when Terbinafine is combined with Lamotrigine.
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Lamotrigine.
TerfenadineThe serum concentration of Lamotrigine can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Lamotrigine can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Lamotrigine can be increased when it is combined with Testosterone.
TetrabenazineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Lamotrigine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Lamotrigine.
ThalidomideLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Lamotrigine.
ThiamylalThe metabolism of Lamotrigine can be increased when combined with Thiamylal.
ThiamylalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Thiamylal.
ThiopentalThe metabolism of Lamotrigine can be increased when combined with Thiopental.
ThiopentalThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Thiopental.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Lamotrigine.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Lamotrigine.
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Lamotrigine.
TiagabineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Tiagabine.
TicagrelorThe serum concentration of Lamotrigine can be increased when it is combined with Ticagrelor.
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Lamotrigine.
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Lamotrigine.
TizanidineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Lamotrigine.
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Lamotrigine.
TolvaptanThe serum concentration of Lamotrigine can be increased when it is combined with Tolvaptan.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Lamotrigine.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Lamotrigine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Lamotrigine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Lamotrigine.
TrazodoneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Trazodone.
TrazodoneThe serum concentration of Lamotrigine can be decreased when it is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Lamotrigine.
TrifluoperazineThe serum concentration of Lamotrigine can be increased when it is combined with Trifluoperazine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Lamotrigine can be increased when it is combined with Triflupromazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Triflupromazine.
TrimazosinTrimazosin may increase the hypotensive activities of Lamotrigine.
TrimethoprimThe serum concentration of Lamotrigine can be decreased when it is combined with Trimethoprim.
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Lamotrigine.
TrimipramineThe serum concentration of Lamotrigine can be increased when it is combined with Trimipramine.
TrimipramineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Lamotrigine.
TroleandomycinThe serum concentration of Lamotrigine can be increased when it is combined with Troleandomycin.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Lamotrigine.
VenlafaxineThe serum concentration of Lamotrigine can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Lamotrigine can be decreased when it is combined with Verapamil.
VigabatrinThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Vilazodone.
VinblastineThe serum concentration of Lamotrigine can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Lamotrigine can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Lamotrigine can be increased when it is combined with Vinorelbine.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Lamotrigine.
VortioxetineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Lamotrigine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Lamotrigine.
ZiconotideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Zimelidine.
ZimelidineThe serum concentration of Lamotrigine can be increased when it is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Lamotrigine.
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Lamotrigine.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Lamotrigine.
ZonisamideThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Lamotrigine.
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Lamotrigine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Lamotrigine.
Food Interactions
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Gene Name:
SCN2A
Uniprot ID:
Q99250
Molecular Weight:
227972.64 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Lipkind GM, Fozzard HA: Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels. Mol Pharmacol. 2005 Dec;68(6):1611-22. Epub 2005 Sep 20. [PubMed:16174788 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Protein homodimerization activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
Gene Name:
UGT1A4
Uniprot ID:
P22310
Molecular Weight:
60024.535 Da
References
  1. Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP: Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35. doi: 10.3109/00498250903188985. [PubMed:19845433 ]
  2. Chen H, Yang K, Choi S, Fischer JH, Jeong H: Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17beta-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy. Drug Metab Dispos. 2009 Sep;37(9):1841-7. doi: 10.1124/dmd.109.026609. Epub 2009 Jun 22. [PubMed:19546240 ]
  3. Argikar UA, Remmel RP: Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica. 2009 May;39(5):355-63. doi: 10.1080/00498250902745082. [PubMed:19387891 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A3
Uniprot ID:
P35503
Molecular Weight:
60337.835 Da
References
  1. Argikar UA, Remmel RP: Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica. 2009 May;39(5):355-63. doi: 10.1080/00498250902745082. [PubMed:19387891 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Luna-Tortos C, Fedrowitz M, Loscher W: Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. doi: 10.1016/j.neuropharm.2008.08.032. Epub 2008 Sep 11. [PubMed:18824002 ]
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Drug created on June 13, 2005 07:24 / Updated on September 24, 2016 02:16