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Identification
NameLamotrigine
Accession NumberDB00555  (APRD00570)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. The exact way lamotrigine works is unknown. [Wikipedia]

Structure
Thumb
Synonyms
SynonymLanguageCode
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazineNot AvailableNot Available
LamictalNot AvailableNot Available
LamotriginaSpanishINN
LamotrigineFrench/GermanINN
LamotriginumLatinINN
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lamictaltablet, chewable5 mgoralGlaxo Smith Kline Llc1998-09-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet, chewable25 mgoralGlaxo Smith Kline Llc1998-09-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
LamictalkitGlaxo Smith Kline Llc2003-09-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet25 mgoralGlaxo Smith Kline Llc1996-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet100 mgoralGlaxo Smith Kline Llc1995-01-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet150 mgoralGlaxo Smith Kline Llc1995-01-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet200 mgoralGlaxo Smith Kline Llc1995-01-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet, chewable2 mgoralGlaxo Smith Kline Llc2000-10-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRtablet, film coated, extended release25 mgoralGlaxo Smith Kline Llc2009-07-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRtablet, film coated, extended release50 mgoralGlaxo Smith Kline Llc2009-07-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRtablet, film coated, extended release100 mgoralGlaxo Smith Kline Llc2009-07-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRtablet, film coated, extended release200 mgoralGlaxo Smith Kline Llc2009-07-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRkitGlaxo Smith Kline Llc2009-07-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRtablet, film coated, extended release300 mgoralGlaxo Smith Kline Llc2011-03-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal ODTtablet, orally disintegrating25 mgoralGlaxo Smith Kline Llc2009-06-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal ODTtablet, orally disintegrating50 mgoralGlaxo Smith Kline Llc2009-06-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal ODTtablet, orally disintegrating100 mgoralGlaxo Smith Kline Llc2009-06-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal ODTtablet, orally disintegrating200 mgoralGlaxo Smith Kline Llc2009-06-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal ODTkitGlaxo Smith Kline Llc2009-06-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictal XRtablet, film coated, extended release250 mgoralGlaxo Smith Kline Llc2011-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
LamictalkitGlaxo Smith Kline Llc2003-09-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralRebel Distributors Corp2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet100 mgoralRebel Distributors Corp1995-01-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet150 mgoralRebel Distributors Corp1995-01-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralRebel Distributors Corp2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralRebel Distributors Corp2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralRebel Distributors Corp2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet100 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet25 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet200 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet150 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet25 mgoralPhysicians Total Care, Inc.2011-02-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet100 mgoralPhysicians Total Care, Inc.2008-05-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet200 mgoralPhysicians Total Care, Inc.2007-05-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet100 mgoralPd Rx Pharmaceuticals, Inc.1995-01-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamictaltablet100 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamictaltablet25 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamictaltablet150 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamictaltablet5 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamictaltablet2 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lamotriginetablet25 mgoralTeva Pharmaceuticals USA Inc2008-07-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralTeva Pharmaceuticals USA Inc2006-06-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralTeva Pharmaceuticals USA Inc2008-07-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralTeva Pharmaceuticals USA Inc2006-08-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralTeva Pharmaceuticals USA Inc2008-07-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralTeva Pharmaceuticals USA Inc2008-07-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, orally disintegrating25 mgoralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, orally disintegrating50 mgoralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, orally disintegrating100 mgoralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, orally disintegrating200 mgoralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2015-01-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralWest ward Pharmaceutical Corp2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralWest ward Pharmaceutical Corp2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralWest ward Pharmaceutical Corp2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralWest ward Pharmaceutical Corp2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
LamotriginekitUpsher Smith Laboratories, Inc.2011-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
LamotriginekitUpsher Smith Laboratories, Inc.2011-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralUpsher Smith Laboratories, Inc.2011-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralUpsher Smith Laboratories, Inc.2011-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralUpsher Smith Laboratories, Inc.2011-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralUpsher Smith Laboratories, Inc.2011-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralMylan Pharmaceuticals Inc.2012-10-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralMylan Pharmaceuticals Inc.2012-10-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralMylan Pharmaceuticals Inc.2012-10-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralMylan Pharmaceuticals Inc.2012-10-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralMylan Pharmaceuticals Inc.2009-01-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralMylan Pharmaceuticals Inc.2009-01-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
LamotriginekitSandoz Inc2010-01-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralSandoz Inc2010-01-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralSandoz Inc2010-01-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralSandoz Inc2010-01-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralSandoz Inc2010-01-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralUpsher Smith Laboratories, Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralUpsher Smith Laboratories, Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralUpsher Smith Laboratories, Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralUpsher Smith Laboratories, Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralTorrent Pharmaceuticals Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralTorrent Pharmaceuticals Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralTorrent Pharmaceuticals Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralTorrent Pharmaceuticals Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
LamotriginekitTorrent Pharmaceuticals Limited2009-09-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release25 mgoralTorrent Pharmaceuticals Limited2013-12-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release50 mgoralTorrent Pharmaceuticals Limited2013-12-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release100 mgoralTorrent Pharmaceuticals Limited2013-12-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release200 mgoralTorrent Pharmaceuticals Limited2013-12-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralCobalt Laboratories2009-07-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralCobalt Laboratories2009-07-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralSTAT Rx USA LLC2010-12-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralSTAT Rx USA LLC2010-12-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralNorth Star Rx Llc2013-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralNorth Star Rx Llc2013-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralNorth Star Rx Llc2013-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralNorth Star Rx Llc2013-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralREMEDYREPACK INC.2011-12-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralREMEDYREPACK INC.2013-04-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralUnichem Pharmaceuticals (USA), Inc.2011-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralAidarex Pharmaceuticals LLC2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralAidarex Pharmaceuticals LLC2011-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralAidarex Pharmaceuticals LLC2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralAv Kare, Inc.2013-04-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralAv Kare, Inc.2013-04-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralAv Kare, Inc.2013-04-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralAv Kare, Inc.2013-04-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralPd Rx Pharmaceuticals, Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralPd Rx Pharmaceuticals, Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralPd Rx Pharmaceuticals, Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralPd Rx Pharmaceuticals, Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralREMEDYREPACK INC.2011-09-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralREMEDYREPACK INC.2011-07-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralREMEDYREPACK INC.2011-08-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralREMEDYREPACK INC.2011-09-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralREMEDYREPACK INC.2011-08-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralREMEDYREPACK INC.2011-08-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralREMEDYREPACK INC.2013-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralREMEDYREPACK INC.2013-05-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralREMEDYREPACK INC.2013-04-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralREMEDYREPACK INC.2013-05-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralREMEDYREPACK INC.2013-04-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralREMEDYREPACK INC.2013-02-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralREMEDYREPACK INC.2013-02-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralUnit Dose Services2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralUnit Dose Services2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralMylan Institutional Inc.2009-03-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralMylan Institutional Inc.2009-03-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralMylan Institutional Inc.2009-06-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralMylan Institutional Inc.2009-06-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralTaro Pharmaceuticals U.S.A., Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralTaro Pharmaceuticals U.S.A., Inc.2009-02-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralTaro Pharmaceuticals U.S.A., Inc.2009-02-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralREMEDYREPACK INC.2013-02-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralREMEDYREPACK INC.2013-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralREMEDYREPACK INC.2013-03-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralREMEDYREPACK INC.2013-05-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralREMEDYREPACK INC.2014-03-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralREMEDYREPACK INC.2014-05-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, film coated, extended release25 mgoralWilshire Pharmaceuticals, Inc.2014-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, film coated, extended release50 mgoralWilshire Pharmaceuticals, Inc.2014-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, film coated, extended release100 mgoralWilshire Pharmaceuticals, Inc.2014-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, film coated, extended release200 mgoralWilshire Pharmaceuticals, Inc.2014-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralPhysicians Total Care, Inc.2008-07-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralPhysicians Total Care, Inc.2008-12-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralPhysicians Total Care, Inc.2009-12-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralPhysicians Total Care, Inc.2012-01-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralDr.Reddy's Laboratories Limited2009-01-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralDr.Reddy's Laboratories Limited2009-01-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralDr.Reddy's Laboratories Limited2009-01-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralDr.Reddy's Laboratories Limited2009-01-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralDr. Reddy's Laboratories Limited2009-01-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralDr. Reddy's Laboratories Limited2009-01-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release300 mgoralDr.Reddy's Laboratories Limited2013-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release25 mgoralDr.Reddy's Laboratories Limited2013-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release50 mgoralDr.Reddy's Laboratories Limited2013-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release100 mgoralDr.Reddy's Laboratories Limited2013-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release200 mgoralDr.Reddy's Laboratories Limited2013-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralCardinal Health2009-09-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralCardinal Health2012-08-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralCardinal Health2012-08-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralCardinal Health2009-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralCardinal Health2009-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release25 mgoralWockhardt Limited2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release200 mgoralWockhardt Limited2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release100 mgoralWockhardt Limited2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release50 mgoralWockhardt Limited2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release300 mgoralWockhardt Limited2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralClinical Solutions Wholesale2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralHikma Pharmaceutical2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralHikma Pharmaceutical2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralHikma Pharmaceutical2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralHikma Pharmaceutical2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralJUBILANT CADISTA PHARMACEUTICALS, INC.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralJubilant Cadista Pharmaceuticals Inc.2011-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralJubilant Cadista Pharmaceuticals Inc.2011-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralApotex Corp2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralApotex Corp2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralApotex Corp2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralApotex Corp2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralREMEDYREPACK INC.2014-08-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralbryant ranch prepack2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralbryant ranch prepack2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralbryant ranch prepack2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralbryant ranch prepack2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2011-06-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2011-06-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralMc Kesson Packaging Sevices A Business Unit Of Mc Kesson Corporation2014-02-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release25 mgoralWockhardt USA LLC.2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release200 mgoralWockhardt USA LLC.2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release100 mgoralWockhardt USA LLC.2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release50 mgoralWockhardt USA LLC.2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, extended release300 mgoralWockhardt USA LLC.2012-11-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralTYA Pharmaceuticals2011-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralTYA Pharmaceuticals2011-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralCadila Healthcare Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet50 mgoralCadila Healthcare Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralCadila Healthcare Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralCadila Healthcare Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralCadila Healthcare Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet250 mgoralCadila Healthcare Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralCadila Healthcare Limited2009-01-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralCadila Healthcare Limited2009-01-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralAurobindo Pharma Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralAurobindo Pharma Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralAurobindo Pharma Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralAurobindo Pharma Limited2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralAurobindo Pharma Limited2009-11-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralAurobindo Pharma Limited2009-11-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralAscend Laboratories, LLC2011-06-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralAscend Laboratories, LLC2011-06-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralAscend Laboratories, LLC2011-06-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralAscend Laboratories, LLC2011-06-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralAmerican Health Packaging2013-07-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralAmerican Health Packaging2013-07-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralAmerican Health Packaging2013-07-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralAmerican Health Packaging2011-06-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralAmerican Health Packaging2014-08-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralCarilion Materials Management2008-08-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralZydus Pharmaceuticals (USA) Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet50 mgoralZydus Pharmaceuticals (USA) Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralZydus Pharmaceuticals (USA) Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralZydus Pharmaceuticals (USA) Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralZydus Pharmaceuticals (USA) Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet250 mgoralZydus Pharmaceuticals (USA) Inc.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralZydus Pharmaceuticals (USA) Inc.2009-01-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralZydus Pharmaceuticals (USA) Inc.2009-01-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable5 mgoralGlenmark Generics Inc., USA2009-02-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet, chewable25 mgoralGlenmark Generics Inc., USA2009-02-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralGlenmark Generics Inc., USA2012-05-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralGlenmark Generics Inc., USA2012-05-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralGlenmark Generics Inc., USA2012-05-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralGlenmark Generics Inc., USA2012-05-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralPreferred Pharmaceuticals, Inc.2014-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralCipla USA Inc.2010-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralCipla USA Inc.2010-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet150 mgoralCipla USA Inc.2010-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet200 mgoralCipla USA Inc.2010-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralMc Kesson Contract Packaging2011-11-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet100 mgoralMc Kesson Contract Packaging2013-05-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Lamotriginetablet25 mgoralSanis Health IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamotriginetablet100 mgoralSanis Health IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamotriginetablet150 mgoralSanis Health IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamotriginetablet25 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamotriginetablet100 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lamotriginetablet150 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Over the Counter ProductsNot Available
International Brands
NameCompany
ConvulsanActavis
CrisometJuste
DafexPhoenix
DaksolPharmavita
DanoptinPliva
DezepilRafarm
ElmendosGlaxoSmithKline
EpilepaxIvax
EpimilIvax
EpiralZentiva
EpitecCipla Medpro
EpitrigineActavis
LabilenoGlaxoSmithKline
LambipolGlaxoSmithKline
LamectPharmaSwiss
LameptilSandoz
Lameptil SSandoz
LametecVitalchem
LamezIntas
Lamictal CDGlaxoSmithKline
LamictinGlaxoSmithKline
LamotrixGlenmark
LarigRowex
MedotriginMedochemie
MogineDouglas
TrimolepPsicofarma
TrogineRanbaxy
XebarinDr Reddys
Brand mixtures
Brand NameIngredients
CionamatLamotrigine and Clonazepam
SaltsNot Available
Categories
CAS number84057-84-1
WeightAverage: 256.091
Monoisotopic: 255.007850663
Chemical FormulaC9H7Cl2N5
InChI KeyPYZRQGJRPPTADH-UHFFFAOYSA-N
InChI
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
IUPAC Name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
SMILES
NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassHalobenzenes
Direct ParentDichlorobenzenes
Alternative Parents
Substituents
  • 1,2-dichlorobenzene
  • Aminotriazine
  • 1,2,4-triazine
  • Imidolactam
  • Triazine
  • Primary aromatic amine
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Primary amine
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.
PharmacodynamicsLamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is also used in the treatment of depression and bipolar disorder. Lamotrigine is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Lamotrigine inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate.
Mechanism of actionOne proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. in vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels and/or calcium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate). Studies on lamotrigine show binding to sodium channels similar to local anesthetics.
Absorption98%
Volume of distribution
  • 0.9 to 1.3 L/kg
Protein binding55%
Metabolism

Hepatic

SubstrateEnzymesProduct
Lamotrigine
lamotrigine-2-N-glucuronideDetails
Route of eliminationNot Available
Half life25 +/- 10 hours (healthy individuals); 42.9 hours (chronic renal failure)
Clearance
  • Apparent plasma cl=0.44 mL/min/kg [healthy volunteers taking single-dose LAMICTAL]
  • Apparent plasma cl=0.58 mL/min/kg [healthy volunteers taking multiple-dose LAMICTAL]
  • Apparent plasma cl=0.30 mL/min/kg [healthy volunteers taking valproate and single-dose LAMICTAL]
  • Apparent plasma cl=0.18 mL/min/kg [healthy volunteers taking valproate and multiple-dose LAMICTAL]
  • Apparent plasma cl=1.1 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and single-dose LAMICTAL]
  • Apparent plasma cl=1.12 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and multiple-dose LAMICTAL]
ToxicityLD50=250 (mg/kg) (in rat, mice); LD50>640 orally (mg/kg) (in rat, mice) (Sawyer). Symptoms of overdose include decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, and rolling eyeballs.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9382
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.7155
P-glycoprotein inhibitor INon-inhibitor0.911
P-glycoprotein inhibitor IINon-inhibitor0.9604
Renal organic cation transporterNon-inhibitor0.8176
CYP450 2C9 substrateNon-substrate0.9162
CYP450 2D6 substrateNon-substrate0.9055
CYP450 3A4 substrateNon-substrate0.6862
CYP450 1A2 substrateNon-inhibitor0.611
CYP450 2C9 substrateNon-inhibitor0.9071
CYP450 2D6 substrateInhibitor0.7007
CYP450 2C19 substrateNon-inhibitor0.8594
CYP450 3A4 substrateNon-inhibitor0.7678
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5515
Ames testNon AMES toxic0.8202
CarcinogenicityNon-carcinogens0.7895
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.7556 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9168
hERG inhibition (predictor II)Non-inhibitor0.8735
Pharmacoeconomics
Manufacturers
  • Glaxosmithkline
  • Aurobindo pharma ltd
  • Dr reddys laboratories ltd
  • Glenmark generics ltd
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Taro pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Zydus pharmaceuticals usa inc
  • Smithkline beecham corp
  • Smithkline beecham corp dba glaxosmithkline
  • Apotex inc
  • Cadista pharmaceuticals inc
  • Lupin ltd
  • Matrix laboratories ltd
  • Roxane laboratories inc
  • Torrent pharmaceuticals ltd
  • Upsher smith laboratories inc
  • Wockhardt ltd
Packagers
Dosage forms
FormRouteStrength
Kit
Tabletoral100 mg
Tabletoral150 mg
Tabletoral2 mg
Tabletoral200 mg
Tabletoral25 mg
Tabletoral250 mg
Tabletoral5 mg
Tabletoral50 mg
Tablet, chewableoral2 mg
Tablet, chewableoral25 mg
Tablet, chewableoral5 mg
Tablet, extended releaseoral100 mg
Tablet, extended releaseoral200 mg
Tablet, extended releaseoral25 mg
Tablet, extended releaseoral300 mg
Tablet, extended releaseoral50 mg
Tablet, film coated, extended releaseoral100 mg
Tablet, film coated, extended releaseoral200 mg
Tablet, film coated, extended releaseoral25 mg
Tablet, film coated, extended releaseoral250 mg
Tablet, film coated, extended releaseoral300 mg
Tablet, film coated, extended releaseoral50 mg
Tablet, orally disintegratingoral100 mg
Tablet, orally disintegratingoral200 mg
Tablet, orally disintegratingoral25 mg
Tablet, orally disintegratingoral50 mg
Prices
Unit descriptionCostUnit
LaMICtal Starter 98 25 (84)-100(14)mg Kit Box556.69USD box
LaMICtal XR 200 mg 24 Hour tablet12.11USD tablet
Lamictal xr 200 mg tablet11.65USD tablet
LaMICtal XR 100 mg 24 Hour tablet11.36USD tablet
Lamictal xr 100 mg tablet10.92USD tablet
Lamictal xr 50 mg tablet10.2USD tablet
Lamictal 200 mg tablet7.44USD tablet
Lamictal odt start kt (orange)7.28USD tablet
Lamictal xr start kit (orange)7.28USD tablet
Lamictal odt 200 mg tablet6.95USD tablet
Lamictal odt 100 mg tablet5.82USD tablet
Lamotrigine 200 mg tablet5.78USD tablet
LaMICtal 25 mg Chew Tabs5.63USD tab
Lamictal odt 50 mg tablet5.46USD tablet
Lamictal tab start kit (green)5.46USD tablet
Lamictal 150 mg tablet5.38USD tablet
Lamictal odt 25 mg tablet5.1USD tablet
Lamictal xr 25 mg tablet5.1USD tablet
Lamictal 100 mg tablet4.72USD tablet
Lamotrigine tablet starter kit4.24USD tablet
Lamotrigine 150 mg tablet3.98USD tablet
Lamictal 25 mg tablet3.78USD tablet
Lamotrigine 100 mg tablet3.52USD tablet
LamoTRIgine 25 mg Chew Tabs3.33USD tab
LamoTRIgine 5 mg Chew Tabs3.18USD tab
Lamotrigine 25 mg tablet2.9USD tablet
Apo-Lamotrigine 150 mg Tablet1.31USD tablet
Mylan-Lamotrigine 150 mg Tablet1.31USD tablet
Novo-Lamotrigine 150 mg Tablet1.31USD tablet
Pms-Lamotrigine 150 mg Tablet1.31USD tablet
Ratio-Lamotrigine 150 mg Tablet1.31USD tablet
Apo-Lamotrigine 100 mg Tablet0.88USD tablet
Mylan-Lamotrigine 100 mg Tablet0.88USD tablet
Novo-Lamotrigine 100 mg Tablet0.88USD tablet
Pms-Lamotrigine 100 mg Tablet0.88USD tablet
Ratio-Lamotrigine 100 mg Tablet0.88USD tablet
Apo-Lamotrigine 25 mg Tablet0.22USD tablet
Mylan-Lamotrigine 25 mg Tablet0.22USD tablet
Novo-Lamotrigine 25 mg Tablet0.22USD tablet
Pms-Lamotrigine 25 mg Tablet0.22USD tablet
Ratio-Lamotrigine 25 mg Tablet0.22USD tablet
Lamictal 5 mg Chewable Tablet0.18USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada22777222001-03-272012-01-29
United States56982261995-07-292012-07-29
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point216-218 °C (uncorr)Not Available
logP2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.488 mg/mLALOGPS
logP1.87ALOGPS
logP1.93ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)14.98ChemAxon
pKa (Strongest Basic)5.87ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area90.71 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity66.62 m3·mol-1ChemAxon
Polarizability23.1 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Grahame Roy Lee, “Process for the preparation of lamotrigine.” U.S. Patent US5925755, issued January, 1981.

US5925755
General Reference
  1. Backonja M: Neuromodulating drugs for the symptomatic treatment of neuropathic pain. Curr Pain Headache Rep. 2004 Jun;8(3):212-6. Pubmed
  2. Barbosa L, Berk M, Vorster M: A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J Clin Psychiatry. 2003 Apr;64(4):403-7. Pubmed
  3. Jensen TS: Anticonvulsants in neuropathic pain: rationale and clinical evidence. Eur J Pain. 2002;6 Suppl A:61-8. Pubmed
  4. Pappagallo M: Newer antiepileptic drugs: possible uses in the treatment of neuropathic pain and migraine. Clin Ther. 2003 Oct;25(10):2506-38. Pubmed
  5. Tehrani SP, Daryaafzoon M, Bakhtiarian A, Ejtemaeemehr S, Sahraei H: The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9. Pubmed
External Links
ATC CodesN03AX09
AHFS Codes
  • 28:12.92
PDB EntriesNot Available
FDA labelDownload (3.15 MB)
MSDSDownload (28.6 KB)
Interactions
Drug Interactions
Drug
ButabarbitalBarbiturates like butabarbital may decrease the serum concentration of lamotrigine. There are separate patient management guidelines for patients age 12 and under and for patients older than 12 years of age. Monitor for decreased serum concentrations/therapeutic effects of lamotrigine if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased.
ButalbitalBarbiturates such as butalbital may decrease the serum concentration of lamotrigine. There are separate management guidelines for patients age 12 and under and for patients older than 12 years of age. Please refer to the current approved prescribing information for additional information. Monitor for decreased serum concentrations/therapeutic effects of lamotrigine if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased.
CarbamazepineLamotrigine may increase the adverse effects of carbamazepine by increasing the concentration of its active metabolite, carbamazepine-epoxide. Carbamazepine may decrease the therapeutic effect of lamotrigine by increasing its metabolism. Lamotrigine doses should be adjusted accordingly. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinue or doses are changed.
ClozapineLamotrigine increases the effect and toxicity of clozapine
DesogestrelThe oral contraceptive decreases the effect of lamotrigine
Ethinyl EstradiolThe oral contraceptive decreases the effect of lamotrigine
EthotoinPhenytoin may reduce levels of lamotrigine
EzogabineIn healthy adults, the AUCs of lamotrigine and ezogabine were both increased. The clinical significance of this is still unknown. Multiple doses of ezogabine also increase the clearance and decrease the terminal half-life of lamotrigine.
FosphenytoinPhenytoin may reduce levels of lamotrigine
MephenytoinPhenytoin may reduce levels of lamotrigine
MestranolThe oral contraceptive decreases the effect of lamotrigine
MethsuximideMethsuximide decreases the effect of lamotrigine
NorethindroneThe oral contraceptive decreases the effect of lamotrigine
PhenytoinPhenytoin may reduce levels of lamotrigine
RifampicinRifampin decreases levels of lamotrigine
ThiopentalThiopental may increase the metabolism and clearance of Lamotrigine. Monitor for decreased therapeutic effect of Lamotrigine if Thiopental is initiated.
TriprolidineThe CNS depressants, Triprolidine and Lamotrigine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Valproic AcidValproic acid may increase the adverse effects of Lamotrigine by increasing Lamotrigine serum concentration. The Lamotrigine dose should be reduced by 50% during concomitant therapy. Monitor for changes in Lamotrigine therapeutic and adverse effects if Valproic acid is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.

Targets

1. Sodium channel protein type 2 subunit alpha

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Sodium channel protein type 2 subunit alpha Q99250 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Lipkind GM, Fozzard HA: Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels. Mol Pharmacol. 2005 Dec;68(6):1611-22. Epub 2005 Sep 20. Pubmed

Enzymes

1. UDP-glucuronosyltransferase 1-4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-4 P22310 Details

References:

  1. Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP: Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35. Pubmed
  2. Chen H, Yang K, Choi S, Fischer JH, Jeong H: Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17beta-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy. Drug Metab Dispos. 2009 Sep;37(9):1841-7. Epub 2009 Jun 22. Pubmed
  3. Argikar UA, Remmel RP: Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica. 2009 May;39(5):355-63. Pubmed

2. UDP-glucuronosyltransferase 1-3

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-3 P35503 Details

References:

  1. Argikar UA, Remmel RP: Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica. 2009 May;39(5):355-63. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Luna-Tortos C, Fedrowitz M, Loscher W: Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. Epub 2008 Sep 11. Pubmed

Comments
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:11