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Identification
NameCephalexin
Accession NumberDB00567  (APRD00250)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. [PubChem]

Structure
Thumb
Synonyms
(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid
7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid
Anhydrous cefalexin
Anhydrous cephalexin
Cefalexin
Cefalexin anhydrous
Cefalexina
Céfalexine
Cefalexinum
Cephalexin anhydrous
External Identifiers
  • LILLY-66873
  • S-6437
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cephalexin Tab 250mgtablet250 mgoralPro Doc Limitee1989-12-312012-07-23Canada
Cephalexin Tab 500mgtablet500 mgoralPro Doc Limitee1989-12-31Not applicableCanada
Dom-cephalexin - Tab 250mgtablet250 mgoralDominion Pharmacal1995-12-31Not applicableCanada
Dom-cephalexin - Tab 500mgtablet500 mgoralDominion Pharmacal1995-12-31Not applicableCanada
Dom-cephalexin 125 - Sus 125mg/5mlsuspension125 mgoralDominion Pharmacal1995-12-31Not applicableCanada
Dom-cephalexin 250 - Sus 250mg/5mlsuspension250 mgoralDominion Pharmacal1995-12-31Not applicableCanada
Keflexcapsule250 mg/1oralShionogi Inc.1971-01-04Not applicableUs
Keflextablet500 mgoralPendopharm Division Of De Pharmascience Inc1972-12-31Not applicableCanada
Keflexpowder for suspension250 mgoralPendopharm Division Of De Pharmascience Inc1971-12-31Not applicableCanada
Keflexpowder for suspension125 mgoralPendopharm Division Of De Pharmascience Inc1971-12-31Not applicableCanada
Keflexcapsule750 mg/1oralShionogi Inc.1971-01-04Not applicableUs
Keflextablet250 mgoralPendopharm Division Of De Pharmascience Inc1977-12-31Not applicableCanada
Keflexcapsule500 mg/1oralShionogi Inc.1971-01-04Not applicableUs
Nu-cephalex Tab 250mgtablet250 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-cephalex Tab 500mgtablet500 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Penta-cephalexin - 250mgtablet250 mgoralPentapharm Ltd.1997-06-252004-07-30Canada
Penta-cephalexin - 500mgtablet500 mgoralPentapharm Ltd.1997-06-252004-07-30Canada
PMS-cephalexin - Tab 250mgtablet250 mgoralPharmascience Inc1995-12-31Not applicableCanada
PMS-cephalexin - Tab 500mgtablet500 mgoralPharmascience Inc1995-12-31Not applicableCanada
PMS-cephalexin 125 - Sus 125mg/5mlsuspension125 mgoralPharmascience Inc1995-12-31Not applicableCanada
PMS-cephalexin 250 - Sus 250mg/5mlsuspension250 mgoralPharmascience Inc1995-12-31Not applicableCanada
Stcc-cephalexin -tab 250mgtablet250 mgoralStcc Inc.1995-12-312002-07-31Canada
Stcc-cephalexin -tab 500mgtablet500 mgoralStcc Inc.1995-12-312002-07-31Canada
Stcc-cephalexin 125 - Orl Sus 125mg/5mlsuspension125 mgoralStcc Inc.1995-12-312002-07-31Canada
Stcc-cephalexin 250 - Sus Orl 250mg/5mlsuspension250 mgoralStcc Inc.1995-12-312002-07-31Canada
Teva-cephalexincapsule250 mgoralTeva Canada Limited1979-12-31Not applicableCanada
Teva-cephalexintablet500 mgoralTeva Canada Limited1983-12-31Not applicableCanada
Teva-cephalexintablet250 mgoralTeva Canada Limited1983-12-31Not applicableCanada
Teva-cephalexincapsule500 mgoralTeva Canada Limited1979-12-31Not applicableCanada
Teva-cephalexin 125powder for suspension125 mgoralTeva Canada Limited1982-12-31Not applicableCanada
Teva-cephalexin 250powder for suspension250 mgoralTeva Canada Limited1982-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-cephalextablet250 mgoralApotex Inc1988-12-31Not applicableCanada
Apo-cephalextablet500 mgoralApotex Inc1988-12-31Not applicableCanada
Cephalexinpowder, for suspension125 mg/5mLoralRebel Distributors Corp2007-12-07Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2010-09-08Not applicableUs
Cephalexincapsule500 mg/1oralREMEDYREPACK INC.2015-01-24Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralProficient Rx LP1990-09-30Not applicableUs
Cephalexincapsule500 mg/1oralMed Vantx, Inc.1990-09-30Not applicableUs
Cephalexincapsule500 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-09Not applicableUs
Cephalexincapsule500 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Cephalexincapsule500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-01-12Not applicableUs
Cephalexincapsule250 mg/1oralAmerican Antibiotics, Inc2011-06-15Not applicableUs
Cephalexincapsule250 mg/1oralA S Medication Solutions Llc2005-11-16Not applicableUs
Cephalexincapsule500 mg/1oralAv Pak2014-09-12Not applicableUs
Cephalexincapsule250 mg/1oralBlenheim Pharmacal, Inc.2010-10-04Not applicableUs
Cephalexincapsule500 mg/1oralAv Kare, Inc.2011-08-11Not applicableUs
Cephalexincapsule250 mg/1oralA S Medication Solutions Llc2006-01-11Not applicableUs
Cephalexinpowder, for suspension125 mg/5mLoralPreferred Pharmaceuticals, Inc.2013-12-03Not applicableUs
Cephalexincapsule250 mg/1oralPreferred Pharmaceuticals Inc.2016-02-11Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralSTAT Rx USA LLC2007-12-04Not applicableUs
Cephalexintablet250 mg/1oralTeva Pharmaceuticals USA Inc1990-09-30Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralOrchid Pharma Inc2011-09-01Not applicableUs
Cephalexincapsule500 mg/1oralREMEDYREPACK INC.2015-06-19Not applicableUs
Cephalexincapsule500 mg/1oralProficient Rx LP2012-01-12Not applicableUs
Cephalexincapsule500 mg/1oralMed Vantx, Inc.2006-02-01Not applicableUs
Cephalexincapsule250 mg/1oralUnit Dose Services2010-06-21Not applicableUs
Cephalexincapsule250 mg/1oralA S Medication Solutions Llc2011-01-20Not applicableUs
Cephalexinfor suspension125 mg/5mLoralPreferred Pharmaceuticals, Inc.2012-01-10Not applicableUs
Cephalexincapsule250 mg/1oralBi Coastal Pharma International Llc2016-02-01Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralRebel Distributors Corp2010-09-21Not applicableUs
Cephalexinsuspension125 mg/5mLoralWest ward Pharmaceutical Corp2009-09-01Not applicableUs
Cephalexincapsule500 mg/1oralAmerican Health Packaging2015-06-05Not applicableUs
Cephalexincapsule500 mg/1oralDIRECT RX2014-01-01Not applicableUs
Cephalexincapsule250 mg/1oralReady Meds2012-01-12Not applicableUs
Cephalexincapsule250 mg/1oralAscend Laboratories, LLC2011-01-20Not applicableUs
Cephalexincapsule500 mg/1oralGen Source Rx2005-11-16Not applicableUs
Cephalexincapsule250 mg/1oralPhysicians Total Care, Inc.2006-10-30Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2009-12-22Not applicableUs
Cephalexincapsule500 mg/1oralPd Rx Pharmaceuticals, Inc.2011-01-20Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2005-11-16Not applicableUs
Cephalexincapsule250 mg/1oralRebel Distributors Corp2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2010-06-11Not applicableUs
Cephalexincapsule500 mg/1oralREMEDYREPACK INC.2015-01-24Not applicableUs
Cephalexincapsule500 mg/1oralProficient Rx LP2006-01-11Not applicableUs
Cephalexincapsule500 mg/1oralAurobindo Pharma Limited2005-11-16Not applicableUs
Cephalexinfor suspension250 mg/5mLoralLupin Pharmaceuticals, Inc.2006-01-11Not applicableUs
Cephalexincapsule500 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Cephalexincapsule500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralApotheca Inc.2008-01-18Not applicableUs
Cephalexincapsule250 mg/1oralA S Medication Solutions Llc2005-11-16Not applicableUs
Cephalexincapsule250 mg/1oralAv Pak2014-09-12Not applicableUs
Cephalexincapsule250 mg/1oralPreferred Pharmaceuticals, Inc.2012-03-05Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralOrchid Pharma Inc2007-04-12Not applicableUs
Cephalexincapsule500 mg/1oralRebel Distributors Corp.2005-11-16Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralTeva Pharmaceuticals USA Inc1990-09-30Not applicableUs
Cephalexincapsule250 mg/1oralAmerican Health Packaging2015-06-05Not applicableUs
Cephalexinsuspension250 mg/5mLoralDIRECT RX2014-01-01Not applicableUs
Cephalexincapsule500 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Cephalexincapsule500 mg/1oralAscend Laboratories, LLC2011-01-20Not applicableUs
Cephalexincapsule250 mg/1oralGen Source Rx2005-11-16Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2011-01-20Not applicableUs
Cephalexincapsule250 mg/1oralBlenheim Pharmacal, Inc.2010-09-08Not applicableUs
Cephalexincapsule250 mg/1oralPd Rx Pharmaceuticals, Inc.2011-01-20Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralRebel Distributors Corp2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralLiberty Pharmaceuticals, Inc.2005-11-16Not applicableUs
Cephalexincapsule500 mg/1oralREMEDYREPACK INC.2014-12-16Not applicableUs
Cephalexincapsule500 mg/1oralSun Pharmaceutical Industries Limited2010-06-21Not applicableUs
Cephalexincapsule250 mg/1oralAurobindo Pharma Limited2005-11-16Not applicableUs
Cephalexinfor suspension125 mg/5mLoralLupin Pharmaceuticals, Inc.2006-01-11Not applicableUs
Cephalexinfor suspension250 mg/5mLoralH.J. Harkins Company, Inc.2005-08-01Not applicableUs
Cephalexincapsule500 mg/1oralPd Rx Pharmaceuticals, Inc.2011-01-28Not applicableUs
Cephalexincapsule250 mg/1oralBlenheim Pharmacal, Inc.2015-09-15Not applicableUs
Cephalexincapsule500 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-08Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2012-01-12Not applicableUs
Cephalexincapsule500 mg/1oralVirtus Pharmaceuticals, LLC2012-01-12Not applicableUs
Cephalexincapsule250 mg/1oralAidarex Pharmaceuticals LLC2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralPreferred Pharmaceuticals, Inc.2012-03-05Not applicableUs
Cephalexinpowder, for suspension125 mg/5mLoralOrchid Pharma Inc2007-04-12Not applicableUs
Cephalexincapsule250 mg/1oralRebel Distributors Corp.2005-11-16Not applicableUs
Cephalexinpowder, for suspension125 mg/5mLoralTeva Pharmaceuticals USA Inc1990-09-30Not applicableUs
Cephalexincapsule500 mg/1oralGolden State Medical Supply, Inc.2005-02-24Not applicableUs
Cephalexincapsule500 mg/1oralDIRECT RX2015-01-01Not applicableUs
Cephalexincapsule250 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Cephalexincapsule500 mg/1oralRed Pharm Drug Inc.2005-12-01Not applicableUs
Cephalexincapsule500 mg/1oralNorthwind Pharmaceuticals2014-06-20Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralA S Medication Solutions Llc1990-09-30Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2012-08-01Not applicableUs
Cephalexincapsule500 mg/1oralPd Rx Pharmaceuticals, Inc.2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralLake Erie Medical DBA Quality Care Products LLC1990-09-30Not applicableUs
Cephalexincapsule250 mg/1oralLiberty Pharmaceuticals, Inc.2006-02-01Not applicableUs
Cephalexinsuspension250 mg/5mLoralCarlsbad Technology, Inc.2009-06-01Not applicableUs
Cephalexincapsule250 mg/1oralSun Pharmaceutical Industries Limited2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralTYA Pharmaceuticals2012-01-12Not applicableUs
Cephalexincapsule500 mg/1oralLupin Pharmaceuticals, Inc.2006-01-11Not applicableUs
Cephalexincapsule500 mg/1oralH.J. Harkins Company, Inc.2006-02-01Not applicableUs
Cephalexincapsule250 mg/1oralPd Rx Pharmaceuticals, Inc.2011-01-28Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2015-09-14Not applicableUs
Cephalexincapsule500 mg/1oralStrategic Pharmaceutical Solutions, Inc. Dba Vet Source2010-11-09Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2012-01-12Not applicableUs
Cephalexincapsule250 mg/1oralVirtus Pharmaceuticals, LLC2012-01-12Not applicableUs
Cephalexincapsule500 mg/1oralAidarex Pharmaceuticals LLC2010-06-21Not applicableUs
Cephalexinpowder, for suspension125 mg/5mLoralSTAT Rx USA LLC2007-12-07Not applicableUs
Cephalexincapsule500 mg/1oralTeva Pharmaceuticals USA Inc1990-09-30Not applicableUs
Cephalexincapsule250 mg/1oralGolden State Medical Supply, Inc.2005-02-24Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralREMEDYREPACK INC.2015-11-12Not applicableUs
Cephalexinsuspension250 mg/5mLoralRanbaxy Pharmaceuticals Inc.2001-10-29Not applicableUs
Cephalexincapsule500 mg/1oralDispensing Solutions, Inc.2005-11-16Not applicableUs
Cephalexincapsule500 mg/1oralNorthwind Pharmaceuticals, LLC2014-11-06Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralA S Medication Solutions Llc1990-09-30Not applicableUs
Cephalexincapsule250 mg/1oralBlenheim Pharmacal, Inc.2012-01-19Not applicableUs
Cephalexincapsule500 mg/1oralPd Rx Pharmaceuticals, Inc.2006-02-01Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralPreferred Pharmaceuticals, Inc.2010-06-21Not applicableUs
Cephalexincapsule500 mg/1oralOrchid Pharma Inc2008-01-18Not applicableUs
Cephalexinsuspension125 mg/5mLoralCarlsbad Technology, Inc.2009-06-01Not applicableUs
Cephalexincapsule500 mg/1oralBelcher Pharmaceuticals, LLC2011-06-15Not applicableUs
Cephalexincapsule250 mg/1oralTYA Pharmaceuticals2006-01-11Not applicableUs
Cephalexincapsule250 mg/1oralLupin Pharmaceuticals, Inc.2006-01-11Not applicableUs
Cephalexincapsule250 mg/1oralH.J. Harkins Company, Inc.2005-12-01Not applicableUs
Cephalexinsuspension250 mg/5mLoralPhysicians Total Care, Inc.1993-06-22Not applicableUs
Cephalexincapsule250 mg/1oralBlenheim Pharmacal, Inc.2014-08-18Not applicableUs
Cephalexincapsule250 mg/1oralStrategic Pharmaceutical Solutions, Inc. Dba Vet Source2010-11-09Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2012-01-12Not applicableUs
Cephalexincapsule500 mg/1oralVirtus Pharmaceuticals2015-06-02Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralREMEDYREPACK INC.2016-04-13Not applicableUs
Cephalexincapsule500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-20Not applicableUs
Cephalexincapsule250 mg/1oralWest ward Pharmaceutical Corp2006-02-01Not applicableUs
Cephalexincapsule250 mg/1oralTeva Pharmaceuticals USA Inc1990-09-30Not applicableUs
Cephalexincapsule500 mg/1oralGolden State Medical Supply, Inc.2011-01-28Not applicableUs
Cephalexincapsule500 mg/1oralREMEDYREPACK INC.2015-10-12Not applicableUs
Cephalexinsuspension125 mg/5mLoralRanbaxy Pharmaceuticals Inc.2001-10-29Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralMed Vantx, Inc.1990-09-30Not applicableUs
Cephalexintablet500 mg/1oralNorthwind Pharmaceuticals, LLC2014-07-18Not applicableUs
Cephalexinpowder, for suspension125 mg/5mLoralA S Medication Solutions Llc1990-09-30Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2012-06-27Not applicableUs
Cephalexincapsule250 mg/1oralPd Rx Pharmaceuticals, Inc.2006-02-01Not applicableUs
Cephalexincapsule250 mg/1oralA S Medication Solutions Llc2012-01-12Not applicableUs
Cephalexincapsule250 mg/1oralPreferred Pharmaceuticals, Inc.2013-02-05Not applicableUs
Cephalexincapsule250 mg/1oralOrchid Pharma Inc2007-12-12Not applicableUs
Cephalexincapsule500 mg/1oralSTAT Rx USA LLC2005-11-16Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Cephalexincapsule500 mg/1oralMedsource Pharmaceuticals2005-11-16Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2005-11-16Not applicableUs
Cephalexincapsule250 mg/1oralVirtus Pharmaceuticals2015-06-02Not applicableUs
Cephalexincapsule250 mg/1oralREMEDYREPACK INC.2016-04-12Not applicableUs
Cephalexinfor suspension250 mg/5mLoralAidarex Pharmaceuticals LLC2006-01-11Not applicableUs
Cephalexincapsule500 mg/1oralWest ward Pharmaceutical Corp2006-02-01Not applicableUs
Cephalexincapsule500 mg/1oralCarlsbad Technology, Inc.2010-10-15Not applicableUs
Cephalexincapsule250 mg/1oralBelcher Pharmaceuticals, LLC2011-06-15Not applicableUs
Cephalexincapsule250 mg/1oralTYA Pharmaceuticals2012-01-12Not applicableUs
Cephalexincapsule750 mg/1oralAscend Laboratories, LLC2012-06-04Not applicableUs
Cephalexincapsule500 mg/1oralGen Source Rx2011-12-01Not applicableUs
Cephalexinsuspension125 mg/5mLoralPhysicians Total Care, Inc.1994-12-09Not applicableUs
Cephalexincapsule250 mg/1oralA S Medication Solutions Llc2006-01-11Not applicableUs
Cephalexincapsule500 mg/1oralUnit Dose Services2010-06-21Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralPreferred Pharmaceuticals Inc.2016-02-01Not applicableUs
Cephalexincapsule250 mg/1oralAv Kare, Inc.2011-08-11Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2010-09-28Not applicableUs
Cephalexincapsule500 mg/1oralREMEDYREPACK INC.2015-05-22Not applicableUs
Cephalexincapsule250 mg/1oralProficient Rx LP2012-01-12Not applicableUs
Cephalexincapsule500 mg/1oralMed Vantx, Inc.2008-01-18Not applicableUs
Cephalexincapsule500 mg/1oralPreferred Pharmaceuticals, Inc.2014-05-28Not applicableUs
Cephalexincapsule500 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Cephalexinpowder, for suspension125 mg/5mLoralOrchid Pharma Inc2011-09-01Not applicableUs
Cephalexincapsule500 mg/1oralAmerican Antibiotics, Inc2011-06-15Not applicableUs
Cephalexincapsule250 mg/1oralGolden State Medical Supply, Inc.2011-01-28Not applicableUs
Cephalexincapsule250 mg/1oralREMEDYREPACK INC.2015-09-17Not applicableUs
Cephalexincapsule500 mg/1oralProficient Rx LP2008-01-18Not applicableUs
Cephalexincapsule500 mg/1oralMed Vantx, Inc.2005-11-16Not applicableUs
Cephalexincapsule500 mg/1oralNorthwind Pharmaceuticals2014-06-17Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2011-01-20Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2010-11-05Not applicableUs
Cephalexincapsule500 mg/1oralSTAT Rx USA LLC2011-01-28Not applicableUs
Cephalexincapsule250 mg/1oralA S Medication Solutions Llc2012-01-12Not applicableUs
Cephalexinpowder, for suspension250 mg/5mLoralPreferred Pharmaceuticals, Inc.2013-12-03Not applicableUs
Cephalexincapsule500 mg/1oralAvera Mc Kennan Hospital2015-03-09Not applicableUs
Cephalexincapsule250 mg/1oralSTAT Rx USA LLC2005-11-16Not applicableUs
Cephalexintablet500 mg/1oralTeva Pharmaceuticals USA Inc1990-09-30Not applicableUs
Cephalexincapsule500 mg/1oralPd Rx Pharmaceuticals, Inc.2011-01-20Not applicableUs
Cephalexincapsule500 mg/1oralA S Medication Solutions Llc2005-11-16Not applicableUs
Cephalexinfor suspension250 mg/5mLoralPreferred Pharmaceuticals, Inc.2012-01-10Not applicableUs
Cephalexincapsule500 mg/1oralBi Coastal Pharma International Llc2016-02-01Not applicableUs
Cephalexinpowder, for suspension125 mg/5mLoralRebel Distributors Corp2010-09-21Not applicableUs
Cephalexinsuspension250 mg/5mLoralWest ward Pharmaceutical Corp2009-09-01Not applicableUs
Cephalexincapsule250 mg/1oralCarlsbad Technology, Inc.2010-10-15Not applicableUs
Cephalexincapsule500 mg/1oralDIRECT RX2015-01-01Not applicableUs
Cephalexincapsule500 mg/1oralReady Meds2012-01-12Not applicableUs
Cephalexincapsule333 mg/1oralAscend Laboratories, LLC2012-06-04Not applicableUs
Cephalexincapsule250 mg/1oralGen Source Rx2011-12-01Not applicableUs
Cephalexincapsule500 mg/1oralPhysicians Total Care, Inc.2004-12-09Not applicableUs
Cephalexincapsule500 mg/1oralBlenheim Pharmacal, Inc.2013-10-03Not applicableUs
Cephalexin USPsuspension250 mg/5mLoralJazeera Pharmaceutical2009-09-01Not applicableUs
Cephalexin USPsuspension125 mg/5mLoralJazeera Pharmaceutical2009-09-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlcephinAlembic
AlexinDabur
AlsporinRenata
CefadinLife
CefalinBioFemme
CeforalTeva
CefovitVitamed
CelexinAtlantic
CephinGeneral Drugs House
CeporexinInvesti
FelexinRemedica
IbilexAlphapharm
KeforalSaiph
L-KeflexShionogi Seiyaku
LarixinTaisho Yakuhin
LonflexUnion
MadlexinMeiji
NufexGeneral Pharma
OriphexMaydsm Trading
OspexinSandoz
PalitrexGalenika
PyassanSanofi
SanaxinSandoz
SencephalinTakeda Pharmaceutical
SepexinHetero
ServisporSandoz
SialexinSiam Bheasach
SporicefRanbaxy
SporidexRanbaxy
SynclAsahi Kasei Pharma
TepaxinTakeda
UphalexinCCM
VoxximRoddensers
WinlexWinston
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Cefalexin hydrochloride
105879-42-3
Thumb
  • InChI Key: YHJDZIQOCSDIQU-OEDJVVDHSA-N
  • Monoisotopic Mass: 401.0812196
  • Average Mass: 401.86
DBSALT001473
Cefalexin monohydrate
23325-78-2
Thumb
  • InChI Key: AVGYWQBCYZHHPN-CYJZLJNKSA-N
  • Monoisotopic Mass: 365.104541898
  • Average Mass: 365.4
DBSALT001841
Cefalexin sodium
38932-40-0
Thumb
  • InChI Key: NZDYPHVJLWMLJI-CYJZLJNKSA-M
  • Monoisotopic Mass: 369.07592138
  • Average Mass: 369.371
DBSALT000261
Categories
UNII5SFF1W6677
CAS number15686-71-2
WeightAverage: 347.389
Monoisotopic: 347.093976737
Chemical FormulaC16H17N3O4S
InChI KeyInChIKey=ZAIPMKNFIOOWCQ-UEKVPHQBSA-N
InChI
InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
IUPAC Name
(6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SMILES
[H][C@]12SCC(C)=C(N1C(=O)[[email protected]]2NC(=O)[[email protected]](N)C1=CC=CC=C1)C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentN-acyl-alpha amino acids and derivatives
Alternative Parents
Substituents
  • N-acyl-alpha amino acid or derivatives
  • Cephem
  • Aralkylamine
  • Benzenoid
  • Monocyclic benzene moiety
  • Meta-thiazine
  • Tertiary carboxylic acid amide
  • Beta-lactam
  • Tertiary amine
  • Lactam
  • Carboxamide group
  • Azetidine
  • Azacycle
  • Organoheterocyclic compound
  • Dialkylthioether
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Hemithioaminal
  • Thioether
  • Monocarboxylic acid or derivatives
  • Enamine
  • Carboxylic acid
  • Carboximidic acid derivative
  • Carboximidic acid
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes; otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis; skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes; bone infections caused by Staphylococcus aureus and/or Proteus mirabilis; genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
PharmacodynamicsCephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic. It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations. It is effective against most gram-positive bacteria.
Mechanism of actionCephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.
Related Articles
AbsorptionWell absorbed from the gastrointestinal tract
Volume of distributionNot Available
Protein binding14%
Metabolism

No appreciable biotransformation in the liver (90% of the drug is excreted unchanged in the urine).

Route of eliminationCephalexin is excreted in the urine by glomerular filtration and tubular secretion. Studies showed that over 90% of the drug was excreted unchanged in the urine within 8 hours.
Half life1 hour
ClearanceNot Available
ToxicitySymptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. The oral median lethal dose of cephalexin in rats is >5000 mg/kg.
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.7537
Blood Brain Barrier-0.996
Caco-2 permeable-0.8956
P-glycoprotein substrateSubstrate0.786
P-glycoprotein inhibitor INon-inhibitor0.9033
P-glycoprotein inhibitor IINon-inhibitor0.9921
Renal organic cation transporterNon-inhibitor0.9485
CYP450 2C9 substrateNon-substrate0.8011
CYP450 2D6 substrateNon-substrate0.8308
CYP450 3A4 substrateNon-substrate0.5289
CYP450 1A2 substrateNon-inhibitor0.9242
CYP450 2C9 inhibitorNon-inhibitor0.9251
CYP450 2D6 inhibitorNon-inhibitor0.9359
CYP450 2C19 inhibitorNon-inhibitor0.922
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9303
Ames testNon AMES toxic0.6834
CarcinogenicityNon-carcinogens0.8861
BiodegradationNot ready biodegradable0.9812
Rat acute toxicity1.2715 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9971
hERG inhibition (predictor II)Non-inhibitor0.8686
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Acs dobfar info sa
  • Apothecon inc div bristol myers squibb
  • Aurobindo pharma ltd inc
  • Barr laboratories inc
  • Belcher pharmaceuticals inc
  • Hikma pharmaceuticals
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lupin ltd
  • Orchid healthcare
  • Purepac pharmaceutical co
  • Ranbaxy laboratories ltd
  • Jerome stevens pharmaceuticals inc
  • Sun pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Yoshitomi pharmaceutical industries ltd
  • Yung shin pharmaceutical industrial co ltd
  • Middlebrook pharmaceuticals inc
  • Vitarine pharmaceuticals inc
  • Lex pharmaceuticals inc
  • Eli lilly and co
Packagers
Dosage forms
FormRouteStrength
Capsuleoral250 mg/1
Capsuleoral333 mg/1
Capsuleoral500 mg/1
For suspensionoral125 mg/5mL
For suspensionoral250 mg/5mL
Powder, for suspensionoral125 mg/5mL
Powder, for suspensionoral250 mg/5mL
Suspensionoral125 mg/5mL
Suspensionoral250 mg/5mL
Tabletoral250 mg/1
Tabletoral500 mg/1
Tabletoral250 mg
Capsuleoral750 mg/1
Powder for suspensionoral125 mg
Powder for suspensionoral250 mg
Tabletoral500 mg
Suspensionoral125 mg
Suspensionoral250 mg
Capsuleoral250 mg
Capsuleoral500 mg
Prices
Unit descriptionCostUnit
Cephalexin 250 mg/5ml Suspension 200ml Bottle32.76USD bottle
Cephalexin 250 mg/5ml Suspension 100ml Bottle19.66USD bottle
Cephalexin 125 mg/5ml Suspension 200ml Bottle16.39USD bottle
Cephalexin 125 mg/5ml Suspension 100ml Bottle15.99USD bottle
Keflex 500 mg capsule5.75USD capsule
Keflex 500 mg pulvule4.99USD each
Keflex 750 mg capsule3.34USD capsule
Cephalexin 500 mg tablet2.25USD tablet
Keflex 250 mg capsule2.2USD capsule
Keflex 250 mg pulvule1.85USD each
Cephalexin 500 mg capsule1.4USD capsule
Cephalexin 250 mg tablet1.17USD tablet
Cephalexin 250 mg capsule0.72USD capsule
Apo-Cephalex 500 mg Tablet0.47USD tablet
Novo-Lexin 500 mg Capsule0.47USD capsule
Novo-Lexin 500 mg Tablet0.47USD tablet
Nu-Cephalex 500 mg Tablet0.47USD tablet
Apo-Cephalex 250 mg Tablet0.24USD tablet
Novo-Lexin 250 mg Capsule0.24USD capsule
Novo-Lexin 250 mg Tablet0.24USD tablet
Nu-Cephalex 250 mg Tablet0.24USD tablet
Novo-Lexin 50 mg/ml Suspension0.14USD ml
Novo-Lexin 25 mg/ml Suspension0.09USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point326.8 °CNot Available
water solubility1789 mg/LNot Available
logP0.65HANSCH,C ET AL. (1995)
pKa4.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.297 mg/mLALOGPS
logP0.55ALOGPS
logP-2.1ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)3.45ChemAxon
pKa (Strongest Basic)7.44ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area112.73 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity88.97 m3·mol-1ChemAxon
Polarizability32.52 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Peter Faarup, “Method of preparing a sparingly soluble complex of cephalexin.” U.S. Patent US4003896, issued May, 1975.

US4003896
General ReferencesNot Available
External Links
ATC CodesJ01DB01
AHFS Codes
  • 08:12.06.04
PDB EntriesNot Available
FDA labelDownload (2.1 MB)
MSDSDownload (93.2 KB)
Interactions
Drug Interactions
Drug
AcenocoumarolCephalexin may increase the anticoagulant activities of Acenocoumarol.
DicoumarolCephalexin may increase the anticoagulant activities of Dicoumarol.
MetforminThe serum concentration of Metformin can be increased when it is combined with Cephalexin.
Picosulfuric acidThe therapeutic efficacy of Sodium picosulfate can be decreased when used in combination with Cephalexin.
ProbenecidThe serum concentration of Cephalexin can be increased when it is combined with Probenecid.
WarfarinCephalexin may increase the anticoagulant activities of Warfarin.
ZincZinc can cause a decrease in the absorption of Cephalexin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc gluconateZinc gluconate can cause a decrease in the absorption of Cephalexin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc sulfateZinc sulfate can cause a decrease in the absorption of Cephalexin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Food Interactions
  • Take on empty stomach: 1 hour before or 2 hours after meals.

Targets

Kind
Protein
Organism
Streptococcus pneumoniae
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type d-ala-d-ala carboxypeptidase activity
Specific Function:
Not Available
Gene Name:
pbp3
Uniprot ID:
Q75Y35
Molecular Weight:
45209.84 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Transferase activity, transferring acyl groups
Specific Function:
Not Available
Gene Name:
pbp2a
Uniprot ID:
Q8DNB6
Molecular Weight:
80797.94 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
  2. Mitsuoka K, Kato Y, Kubo Y, Tsuji A: Functional expression of stereoselective metabolism of cephalexin by exogenous transfection of oligopeptide transporter PEPT1. Drug Metab Dispos. 2007 Mar;35(3):356-62. Epub 2006 Dec 1. [PubMed:17142565 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Transferase activity, transferring acyl groups
Specific Function:
Not Available
Gene Name:
pbp1b
Uniprot ID:
Q7CRA4
Molecular Weight:
89479.92 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Penicillin binding
Specific Function:
Not Available
Gene Name:
penA
Uniprot ID:
P0A3M6
Molecular Weight:
73872.305 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Penicillin binding
Specific Function:
Cell wall formation.
Gene Name:
pbpA
Uniprot ID:
Q8DR59
Molecular Weight:
79700.9 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other/unknown
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Bratlid D, Bergan T: Displacement of albumin-bound antimicrobial agents by bilirubin. Pharmacology. 1976;14(5):464-72. [PubMed:1031216 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. [PubMed:10636865 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Proton-dependent oligopeptide secondary active transmembrane transporter activity
Specific Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
Gene Name:
SLC15A1
Uniprot ID:
P46059
Molecular Weight:
78805.265 Da
References
  1. Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH: Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem. 1995 Mar 24;270(12):6456-63. [PubMed:7896779 ]
  2. Wenzel U, Gebert I, Weintraut H, Weber WM, Clauss W, Daniel H: Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. J Pharmacol Exp Ther. 1996 May;277(2):831-9. [PubMed:8627565 ]
  3. Covitz KM, Amidon GL, Sadee W: Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res. 1996 Nov;13(11):1631-4. [PubMed:8956326 ]
  4. Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL: CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50. [PubMed:10052994 ]
  5. Guo A, Hu P, Balimane PV, Leibach FH, Sinko PJ: Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. J Pharmacol Exp Ther. 1999 Apr;289(1):448-54. [PubMed:10087037 ]
  6. Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. [PubMed:15567297 ]
  7. Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. [PubMed:9374833 ]
  8. Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH: Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995 Oct 27;270(43):25672-7. [PubMed:7592745 ]
  9. Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, Shiraga T, Miyamoto K, Takeda E, Higashida H, Tsuji A: The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine. J Pharm Pharmacol. 1997 Aug;49(8):796-801. [PubMed:9379359 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Peptide:proton symporter activity
Specific Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.
Gene Name:
SLC15A2
Uniprot ID:
Q16348
Molecular Weight:
81782.77 Da
References
  1. Liu W, Liang R, Ramamoorthy S, Fei YJ, Ganapathy ME, Hediger MA, Ganapathy V, Leibach FH: Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. Biochim Biophys Acta. 1995 May 4;1235(2):461-6. [PubMed:7756356 ]
  2. Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH: Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995 Oct 27;270(43):25672-7. [PubMed:7592745 ]
  3. Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. [PubMed:9374833 ]
  4. Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. [PubMed:15567297 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. [PubMed:12005172 ]
  2. Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. [PubMed:10411577 ]
  3. Uwai Y, Saito H, Inui K: Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone. Drug Metab Pharmacokinet. 2002;17(2):125-9. [PubMed:15618660 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. [PubMed:12005172 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Monovalent cation:proton antiporter activity
Specific Function:
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport...
Gene Name:
SLC47A1
Uniprot ID:
Q96FL8
Molecular Weight:
61921.585 Da
References
  1. Watanabe S, Tsuda M, Terada T, Katsura T, Inui K: Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6. doi: 10.1124/jpet.110.169433. Epub 2010 May 19. [PubMed:20484555 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23