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Identification
NameCephalexin
Accession NumberDB00567  (APRD00250)
TypeSmall Molecule
GroupsApproved
Description

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidNot AvailableNot Available
7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acidNot AvailableNot Available
7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acidNot AvailableNot Available
CefalexinNot AvailableINN
CefalexinaSpanishINN
CéfalexineFrenchINN
CefalexinumLatinINN
CelexinNot AvailableNot Available
CepastarNot AvailableNot Available
CepexinNot AvailableNot Available
CephacillinNot AvailableNot Available
CéphalexineFrenchNot Available
CeporexinNot AvailableNot Available
CEXNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Keflexcapsule250 mgoralShionogi Inc.1971-01-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Keflexcapsule500 mgoralShionogi Inc.1971-01-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Keflexcapsule750 mgoralShionogi Inc.1971-01-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Keflextablet250 mgoralPendopharm Division Of De Pharmascience IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Keflextablet500 mgoralPendopharm Division Of De Pharmascience IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Keflexpowder for suspension250 mgoralPendopharm Division Of De Pharmascience IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Keflexpowder for suspension125 mgoralPendopharm Division Of De Pharmascience IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cephalexintablet250 mgoralTeva Pharmaceuticals USA Inc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexintablet500 mgoralTeva Pharmaceuticals USA Inc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralTeva Pharmaceuticals USA Inc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralTeva Pharmaceuticals USA Inc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension125 mg/5mLoralTeva Pharmaceuticals USA Inc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralTeva Pharmaceuticals USA Inc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinsuspension125 mg/5mLoralWest ward Pharmaceutical Corp2009-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinsuspension250 mg/5mLoralWest ward Pharmaceutical Corp2009-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralWest ward Pharmaceutical Corp2006-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralWest ward Pharmaceutical Corp2006-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralLiberty Pharmaceuticals, Inc.2006-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralLiberty Pharmaceuticals, Inc.2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBlenheim Pharmacal, Inc.2010-06-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBlenheim Pharmacal, Inc.2010-09-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBlenheim Pharmacal, Inc.2010-09-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralBlenheim Pharmacal, Inc.2010-10-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBlenheim Pharmacal, Inc.2010-11-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBlenheim Pharmacal, Inc.2012-06-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBlenheim Pharmacal, Inc.2012-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBlenheim Pharmacal, Inc.2009-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralAmerican Antibiotics, Inc2011-06-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralAmerican Antibiotics, Inc2011-06-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralSTAT Rx USA LLC2007-12-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralSTAT Rx USA LLC2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralSTAT Rx USA LLC2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension125 mg/5mLoralSTAT Rx USA LLC2007-12-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralRebel Distributors Corp.2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralRebel Distributors Corp.2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralRebel Distributors Corp2010-09-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension125 mg/5mLoralRebel Distributors Corp2010-09-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralAidarex Pharmaceuticals LLC2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralAidarex Pharmaceuticals LLC2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinfor suspension250 mg/5mLoralAidarex Pharmaceuticals LLC2006-01-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralLake Erie Medical DBA Quality Care Products LLC2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralLake Erie Medical DBA Quality Care Products LLC1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralKaralex Pharma LLC2007-12-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralKaralex Pharma LLC2008-01-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension125 mg/5mLoralOrchid Pharma Inc2007-04-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralOrchid Pharma Inc2007-04-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralRebel Distributors Corp2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralRebel Distributors Corp2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension125 mg/5mLoralRebel Distributors Corp2007-12-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralAv Kare, Inc.2011-08-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralAv Kare, Inc.2011-08-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralSTAT Rx USA LLC2011-01-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralPd Rx Pharmaceuticals, Inc.2006-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralPd Rx Pharmaceuticals, Inc.2006-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralPd Rx Pharmaceuticals, Inc.2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralPd Rx Pharmaceuticals, Inc.2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralPd Rx Pharmaceuticals, Inc.2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralStrategic Pharmaceutical Solutions, Inc. Dba Vet Source2010-11-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralStrategic Pharmaceutical Solutions, Inc. Dba Vet Source2010-11-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralAv Pak2014-09-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralAv Pak2014-09-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralUnit Dose Services2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralUnit Dose Services2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralNorthwind Pharmaceuticals2014-06-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexintablet500 mgoralNorthwind Pharmaceuticals, LLC2014-07-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralNorthwind Pharmaceuticals, LLC2014-11-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralNorthwind Pharmaceuticals2014-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralGen Source Rx2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralGen Source Rx2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralGen Source Rx2011-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralGen Source Rx2011-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralH.J. Harkins Company, Inc.2005-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralH.J. Harkins Company, Inc.2006-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinfor suspension250 mg/5mLoralH.J. Harkins Company, Inc.2005-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralState of Florida DOH Central Pharmacy2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralA S Medication Solutions Llc2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralA S Medication Solutions Llc2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension125 mg/5mLoralA S Medication Solutions Llc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralA S Medication Solutions Llc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralA S Medication Solutions Llc1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralA S Medication Solutions Llc2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralPhysicians Total Care, Inc.2006-10-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralPhysicians Total Care, Inc.2004-12-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinsuspension125 mg/5mLoralPhysicians Total Care, Inc.1994-12-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinsuspension250 mg/5mLoralPhysicians Total Care, Inc.1993-06-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralPd Rx Pharmaceuticals, Inc.2011-01-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralPd Rx Pharmaceuticals, Inc.2011-01-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralLake Erie Medical DBA Quality Care Products LLC2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralLake Erie Medical DBA Quality Care Products LLC2012-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension125 mg/5mLoralOrchid Pharma Inc2011-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralOrchid Pharma Inc2011-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralGolden State Medical Supply, Inc.2011-01-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralGolden State Medical Supply, Inc.2011-01-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralGolden State Medical Supply, Inc.2005-02-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralGolden State Medical Supply, Inc.2005-02-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralCarlsbad Technology, Inc.2010-10-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralCarlsbad Technology, Inc.2010-10-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinsuspension125 mg/5mLoralCarlsbad Technology, Inc.2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinsuspension250 mg/5mLoralCarlsbad Technology, Inc.2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralREMEDYREPACK INC.2014-12-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralREMEDYREPACK INC.2015-01-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralREMEDYREPACK INC.2015-01-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralBelcher Pharmaceuticals, LLC2011-06-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralBelcher Pharmaceuticals, LLC2011-06-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralSun Pharmaceutical Industries Limited2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralSun Pharmaceutical Industries Limited2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralProficient Rx LP2006-01-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralProficient Rx LP1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralProficient Rx LP2012-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinsuspension125 mg/5mLoralRanbaxy Pharmaceuticals Inc.2001-10-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinsuspension250 mg/5mLoralRanbaxy Pharmaceuticals Inc.2001-10-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralAltura Pharmaceuticals, Inc.2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralAltura Pharmaceuticals, Inc.2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralReady Meds2012-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralReady Meds2012-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralTYA Pharmaceuticals2012-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralTYA Pharmaceuticals2006-01-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralTYA Pharmaceuticals2012-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralAurobindo Pharma Limited2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralAurobindo Pharma Limited2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralMed Vantx, Inc.1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralMed Vantx, Inc.2008-01-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralMed Vantx, Inc.2006-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralMed Vantx, Inc.2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralMed Vantx, Inc.1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralDispensing Solutions, Inc.2005-11-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralRed Pharm Drug Inc.2005-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralAscend Laboratories, LLC2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralAscend Laboratories, LLC2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule333 mgoralAscend Laboratories, LLC2012-06-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule750 mgoralAscend Laboratories, LLC2012-06-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralLupin Pharmaceuticals, Inc.2006-01-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralLupin Pharmaceuticals, Inc.2006-01-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinfor suspension125 mg/5mLoralLupin Pharmaceuticals, Inc.2006-01-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinfor suspension250 mg/5mLoralLupin Pharmaceuticals, Inc.2006-01-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexin USPsuspension125 mg/5mLoralJazeera Pharmaceutical2009-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexin USPsuspension250 mg/5mLoralJazeera Pharmaceutical2009-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralPreferred Pharmaceuticals, Inc.2014-05-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension125 mg/5mLoralPreferred Pharmaceuticals, Inc.2013-12-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinpowder, for suspension250 mg/5mLoralPreferred Pharmaceuticals, Inc.2013-12-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralPreferred Pharmaceuticals, Inc.2013-02-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralPreferred Pharmaceuticals, Inc.2010-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralPreferred Pharmaceuticals, Inc.2012-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralPreferred Pharmaceuticals, Inc.2012-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinfor suspension125 mg/5mLoralPreferred Pharmaceuticals, Inc.2012-01-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexinfor suspension250 mg/5mLoralPreferred Pharmaceuticals, Inc.2012-01-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule250 mgoralVirtus Pharmaceuticals, LLC2012-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cephalexincapsule500 mgoralVirtus Pharmaceuticals, LLC2012-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
AlcephinAlembic
AlexinDabur
AlsporinRenata
CefadinLife
CefalinBioFemme
CeforalTeva
CefovitVitamed
CelexinAtlantic
CephinGeneral Drugs House
CeporexinInvesti
FelexinRemedica
IbilexAlphapharm
KeforalSaiph
L-KeflexShionogi Seiyaku
LarixinTaisho Yakuhin
LonflexUnion
MadlexinMeiji
NufexGeneral Pharma
OriphexMaydsm Trading
OspexinSandoz
PalitrexGalenika
PyassanSanofi
SanaxinSandoz
SencephalinTakeda Pharmaceutical
SepexinHetero
ServisporSandoz
SialexinSiam Bheasach
SporicefRanbaxy
SporidexRanbaxy
SynclAsahi Kasei Pharma
TepaxinTakeda
UphalexinCCM
VoxximRoddensers
WinlexWinston
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Cefalexin Sodium
38932-40-0
Thumb
  • InChI Key: NZDYPHVJLWMLJI-CYJZLJNKSA-M
  • Monoisotopic Mass: 369.07592138
  • Average Mass: 369.371
DBSALT000261
Categories
CAS number15686-71-2
WeightAverage: 347.389
Monoisotopic: 347.093976737
Chemical FormulaC16H17N3O4S
InChI KeyZAIPMKNFIOOWCQ-UEKVPHQBSA-N
InChI
InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
IUPAC Name
(6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SMILES
[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=CC=C1)C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentN-acyl-alpha amino acids and derivatives
Alternative Parents
Substituents
  • N-acyl-alpha amino acid or derivatives
  • Cephem
  • Aralkylamine
  • Benzenoid
  • Monocyclic benzene moiety
  • Meta-thiazine
  • Tertiary carboxylic acid amide
  • Beta-lactam
  • Tertiary amine
  • Lactam
  • Carboxamide group
  • Azetidine
  • Azacycle
  • Organoheterocyclic compound
  • Dialkylthioether
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Hemithioaminal
  • Thioether
  • Monocarboxylic acid or derivatives
  • Enamine
  • Carboxylic acid
  • Carboximidic acid derivative
  • Carboximidic acid
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes; otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis; skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes; bone infections caused by Staphylococcus aureus and/or Proteus mirabilis; genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
PharmacodynamicsCephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic. It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations. It is effective against most gram-positive bacteria.
Mechanism of actionCephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.
AbsorptionWell absorbed from the gastrointestinal tract
Volume of distributionNot Available
Protein binding14%
Metabolism

No appreciable biotransformation in the liver (90% of the drug is excreted unchanged in the urine).

Route of eliminationCephalexin is excreted in the urine by glomerular filtration and tubular secretion. Studies showed that over 90% of the drug was excreted unchanged in the urine within 8 hours.
Half life1 hour
ClearanceNot Available
ToxicitySymptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. The oral median lethal dose of cephalexin in rats is >5000 mg/kg.
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.7537
Blood Brain Barrier-0.996
Caco-2 permeable-0.8956
P-glycoprotein substrateSubstrate0.786
P-glycoprotein inhibitor INon-inhibitor0.9033
P-glycoprotein inhibitor IINon-inhibitor0.9921
Renal organic cation transporterNon-inhibitor0.9485
CYP450 2C9 substrateNon-substrate0.8011
CYP450 2D6 substrateNon-substrate0.8308
CYP450 3A4 substrateNon-substrate0.5289
CYP450 1A2 substrateNon-inhibitor0.9242
CYP450 2C9 substrateNon-inhibitor0.9251
CYP450 2D6 substrateNon-inhibitor0.9359
CYP450 2C19 substrateNon-inhibitor0.922
CYP450 3A4 substrateNon-inhibitor0.831
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9303
Ames testNon AMES toxic0.6834
CarcinogenicityNon-carcinogens0.8861
BiodegradationNot ready biodegradable0.9812
Rat acute toxicity1.2715 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9971
hERG inhibition (predictor II)Non-inhibitor0.8686
Pharmacoeconomics
Manufacturers
  • Acs dobfar info sa
  • Apothecon inc div bristol myers squibb
  • Aurobindo pharma ltd inc
  • Barr laboratories inc
  • Belcher pharmaceuticals inc
  • Hikma pharmaceuticals
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lupin ltd
  • Orchid healthcare
  • Purepac pharmaceutical co
  • Ranbaxy laboratories ltd
  • Jerome stevens pharmaceuticals inc
  • Sun pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Yoshitomi pharmaceutical industries ltd
  • Yung shin pharmaceutical industrial co ltd
  • Middlebrook pharmaceuticals inc
  • Vitarine pharmaceuticals inc
  • Lex pharmaceuticals inc
  • Eli lilly and co
Packagers
Dosage forms
FormRouteStrength
Capsuleoral250 mg
Capsuleoral333 mg
Capsuleoral500 mg
Capsuleoral750 mg
For suspensionoral125 mg/5mL
For suspensionoral250 mg/5mL
Powder for suspensionoral125 mg
Powder for suspensionoral250 mg
Powder, for suspensionoral125 mg/5mL
Powder, for suspensionoral250 mg/5mL
Suspensionoral125 mg/5mL
Suspensionoral250 mg/5mL
Tabletoral250 mg
Tabletoral500 mg
Prices
Unit descriptionCostUnit
Cephalexin 250 mg/5ml Suspension 200ml Bottle32.76USD bottle
Cephalexin 250 mg/5ml Suspension 100ml Bottle19.66USD bottle
Cephalexin 125 mg/5ml Suspension 200ml Bottle16.39USD bottle
Cephalexin 125 mg/5ml Suspension 100ml Bottle15.99USD bottle
Keflex 500 mg capsule5.75USD capsule
Keflex 500 mg pulvule4.99USD each
Keflex 750 mg capsule3.34USD capsule
Cephalexin 500 mg tablet2.25USD tablet
Keflex 250 mg capsule2.2USD capsule
Keflex 250 mg pulvule1.85USD each
Cephalexin 500 mg capsule1.4USD capsule
Cephalexin 250 mg tablet1.17USD tablet
Cephalexin 250 mg capsule0.72USD capsule
Apo-Cephalex 500 mg Tablet0.47USD tablet
Novo-Lexin 500 mg Capsule0.47USD capsule
Novo-Lexin 500 mg Tablet0.47USD tablet
Nu-Cephalex 500 mg Tablet0.47USD tablet
Apo-Cephalex 250 mg Tablet0.24USD tablet
Novo-Lexin 250 mg Capsule0.24USD capsule
Novo-Lexin 250 mg Tablet0.24USD tablet
Nu-Cephalex 250 mg Tablet0.24USD tablet
Novo-Lexin 50 mg/ml Suspension0.14USD ml
Novo-Lexin 25 mg/ml Suspension0.09USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point326.8 °CNot Available
water solubility1789 mg/LNot Available
logP0.65HANSCH,C ET AL. (1995)
pKa4.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.297 mg/mLALOGPS
logP0.55ALOGPS
logP-2.1ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)3.45ChemAxon
pKa (Strongest Basic)7.44ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area112.73 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity88.97 m3·mol-1ChemAxon
Polarizability32.52 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Peter Faarup, “Method of preparing a sparingly soluble complex of cephalexin.” U.S. Patent US4003896, issued May, 1975.

US4003896
General ReferenceNot Available
External Links
ATC CodesJ01DB01
AHFS Codes
  • 08:12.06.04
PDB EntriesNot Available
FDA labelDownload (2.1 MB)
MSDSDownload (93.2 KB)
Interactions
Drug Interactions
Drug
ProbenecidProbenecid may increase the serum level of cephalexin.
Food Interactions
  • Take on empty stomach: 1 hour before or 2 hours after meals.

Targets

1. Penicillin-binding protein 3

Kind: protein

Organism: Streptococcus pneumoniae

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Penicillin-binding protein 3 Q75Y35 Details

References:

  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. Pubmed

2. Penicillin-binding protein 2a

Kind: protein

Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Penicillin-binding protein 2a Q8DNB6 Details

References:

  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. Pubmed
  2. Mitsuoka K, Kato Y, Kubo Y, Tsuji A: Functional expression of stereoselective metabolism of cephalexin by exogenous transfection of oligopeptide transporter PEPT1. Drug Metab Dispos. 2007 Mar;35(3):356-62. Epub 2006 Dec 1. Pubmed

3. Penicillin-binding protein 1b

Kind: protein

Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Penicillin-binding protein 1b Q7CRA4 Details

References:

  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. Pubmed

4. Penicillin-binding protein 2B

Kind: protein

Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Penicillin-binding protein 2B P0A3M6 Details

References:

  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. Pubmed

5. Penicillin-binding protein 1A

Kind: protein

Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Penicillin-binding protein 1A Q8DR59 Details

References:

  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. Pubmed

Enzymes

1. Cytochrome P450 2D6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

2. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Carriers

1. Serum albumin

Kind: protein

Organism: Human

Pharmacological action: no

Actions: other/unknown

Components

Name UniProt ID Details
Serum albumin P02768 Details

References:

  1. Bratlid D, Bergan T: Displacement of albumin-bound antimicrobial agents by bilirubin. Pharmacology. 1976;14(5):464-72. Pubmed

Transporters

1. Solute carrier family 22 member 5

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 5 O76082 Details

References:

  1. Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. Pubmed

2. Solute carrier family 15 member 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Solute carrier family 15 member 1 P46059 Details

References:

  1. Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH: Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem. 1995 Mar 24;270(12):6456-63. Pubmed
  2. Wenzel U, Gebert I, Weintraut H, Weber WM, Clauss W, Daniel H: Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. J Pharmacol Exp Ther. 1996 May;277(2):831-9. Pubmed
  3. Covitz KM, Amidon GL, Sadee W: Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res. 1996 Nov;13(11):1631-4. Pubmed
  4. Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL: CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50. Pubmed
  5. Guo A, Hu P, Balimane PV, Leibach FH, Sinko PJ: Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. J Pharmacol Exp Ther. 1999 Apr;289(1):448-54. Pubmed
  6. Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. Pubmed
  7. Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. Pubmed
  8. Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH: Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995 Oct 27;270(43):25672-7. Pubmed
  9. Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, Shiraga T, Miyamoto K, Takeda E, Higashida H, Tsuji A: The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine. J Pharm Pharmacol. 1997 Aug;49(8):796-801. Pubmed

3. Solute carrier family 15 member 2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 15 member 2 Q16348 Details

References:

  1. Liu W, Liang R, Ramamoorthy S, Fei YJ, Ganapathy ME, Hediger MA, Ganapathy V, Leibach FH: Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. Biochim Biophys Acta. 1995 May 4;1235(2):461-6. Pubmed
  2. Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH: Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995 Oct 27;270(43):25672-7. Pubmed
  3. Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. Pubmed
  4. Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. Pubmed

4. Solute carrier family 22 member 6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 6 Q4U2R8 Details

References:

  1. Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. Pubmed
  2. Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. Pubmed
  3. Uwai Y, Saito H, Inui K: Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone. Drug Metab Pharmacokinet. 2002;17(2):125-9. Pubmed

5. Solute carrier family 22 member 8

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 8 Q8TCC7 Details

References:

  1. Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. Pubmed

6. Multidrug and toxin extrusion protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Multidrug and toxin extrusion protein 1 Q96FL8 Details

References:

  1. Watanabe S, Tsuda M, Terada T, Katsura T, Inui K: Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6. Epub 2010 May 19. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:11