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Identification
NameTriamcinolone
Accession NumberDB00620  (APRD00422)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)

Structure
Thumb
Synonyms
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
Fluoxyprednisolone
Tiamcinolonum
Triamcinolona
Triamcinolonum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Allernazespray, metered.5 mg/mLnasalLupin Pharmaceuticals2011-02-01Not applicableUs
Aristocort - Syr Orl 0.4mg/mlsyrup.4 mgoralGlades, Division Of Stiefel Canada Inc.1996-10-101997-08-05Canada
Aristocort - Tab 4mgtablet4 mgoralGlades, Division Of Stiefel Canada Inc.1998-05-112004-01-27Canada
Aristocort Ccream0.5 %topicalValeant Canada Lp Valeant Canada S.E.C.1997-10-21Not applicableCanada
Aristocort C Crm 0.5%cream5 mgtopicalLederle Cyanamid Canada Inc.1965-12-311997-08-14Canada
Aristocort D - Crm Top 0.025%cream.025 %topicalGlades, Division Of Stiefel Canada Inc.1996-10-101998-07-09Canada
Aristocort D Crm 0.025%cream.25 mgtopicalLederle Cyanamid Canada Inc.1974-12-311997-01-29Canada
Aristocort Forte - Liq Ia Im Isy 40mg/mlliquid40 mgintra-articular; intramuscular; intrasynovialGlades, Division Of Stiefel Canada Inc.1996-12-062000-12-04Canada
Aristocort Forte Inj 40mg/mlliquid40 mgintra-articular; intramuscular; intrasynovialLederle Cyanamid Canada Inc.1962-12-311997-01-29Canada
Aristocort Inj Intralesional 25mg/mlliquid25 mgintra-articular; intradermal; intramuscularLederle Cyanamid Canada Inc.1962-12-311997-01-29Canada
Aristocort Inj Intralesional-25mg/mlliquid25 mgintra-articular; intradermal; intramuscularGlades, Division Of Stiefel Canada Inc.1997-01-202001-08-21Canada
Aristocort Rointment0.1 %topicalValeant Canada Lp Valeant Canada S.E.C.1997-04-14Not applicableCanada
Aristocort Rcream0.1 %topicalValeant Canada Lp Valeant Canada S.E.C.1996-10-10Not applicableCanada
Aristocort Rointment0.1 %topicalValeant Canada Lp Valeant Canada S.E.C.1997-04-14Not applicableCanada
Aristocort R Crm 0.1%cream1 mgtopicalLederle Cyanamid Canada Inc.1965-12-311997-01-29Canada
Aristocort R Ont 0.1%ointment.1 %topicalLederle Cyanamid Canada Inc.1969-12-311997-08-14Canada
Aristocort Syr 2mg/5mlsyrup2 mgoralLederle Cyanamid Canada Inc.1960-12-311997-01-29Canada
Aristocort Tab 2mgtablet2 mgoralLederle Cyanamid Canada Inc.1958-12-311997-01-29Canada
Aristocort Tab 4mgtablet4 mgoralLederle Cyanamid Canada Inc.1958-12-311997-08-14Canada
Aristocort-tab 2mgtablet2 mgoralGlades, Division Of Stiefel Canada Inc.1997-01-202001-10-10Canada
Aristospaninjection, suspension20 mg/mLintra-articular; parenteralSandoz Inc1969-07-29Not applicableUs
Aristospaninjection, suspension5 mg/mLintralesional; parenteralSandoz Inc1969-07-29Not applicableUs
Aristospansuspension20 mgintra-articularValeo Pharma Inc1997-01-20Not applicableCanada
Aristospan Sus 20mg/mlsuspension20 mgintra-articularLederle Cyanamid Canada Inc.1975-12-311997-01-29Canada
Azmacortmetered-dose aerosol200 mcginhalationAventis Pharma Inc1989-12-312003-07-22Canada
Kenalogaerosol, spray.147 mg/gtopicalRanbaxy Laboratories Inc.2009-05-19Not applicableUs
Kenalog Cream 0.1%cream1 mgtopicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1959-12-312006-02-10Canada
Kenalog In Orabase 0.1%paste1 mgdentalBristol Myers Squibb Canada1961-12-312008-09-04Canada
Kenalog Ointment 0.1%ointment1 mgtopicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1958-12-312004-08-05Canada
Kenalog Ont 0.1%ointment1 mgtopicalSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.1958-12-311997-08-14Canada
Kenalog-10injection, suspension10 mg/mLintra-articular; intralesionalDispensing Solutions, Inc.2009-06-01Not applicableUs
Kenalog-10injection, suspension10 mg/mLintra-articular; intralesionalPhysicians Total Care, Inc.2000-05-02Not applicableUs
Kenalog-10injection, suspension10 mg/mLintra-articular; intralesionalE.R. Squibb & Sons, L.L.C.2009-06-01Not applicableUs
Kenalog-10 Injection 10mg/mlsuspension10 mgintra-articular; intrabursal; intradermal; intrasynovialBristol Myers Squibb Canada1966-12-31Not applicableCanada
Kenalog-40injection, suspension40 mg/mLintra-articular; intramuscularRebel Distributors2009-06-01Not applicableUs
Kenalog-40injection, suspension40 mg/mLintra-articular; intramuscularE.R. Squibb & Sons, L.L.C.2009-06-01Not applicableUs
Kenalog-40injection, suspension40 mg/mLintra-articular; intramuscularDispensing Solutions, Inc.2009-06-01Not applicableUs
Kenalog-40injection, suspension40 mg/mLintra-articular; intramuscularPhysicians Total Care, Inc.1996-06-11Not applicableUs
Kenalog-40injection, suspension40 mg/mLintramuscularREMEDYREPACK INC.2013-09-24Not applicableUs
Kenalog-40injection, suspension40 mg/mLintra-articular; intramuscularProficient Rx LP2009-06-01Not applicableUs
Kenalog-40injection, suspension40 mg/1intramuscularREMEDYREPACK INC.2013-04-11Not applicableUs
Kenalog-40injection, suspension40 mg/1intramuscularREMEDYREPACK INC.2013-04-11Not applicableUs
Kenalog-40 Injection 40mg/mlsuspension40 mgintra-articular; intramuscularBristol Myers Squibb Canada1973-12-31Not applicableCanada
Nasacortmetered-dose aerosol100 mcgnasalSanofi Aventis Canada Inc1992-12-312012-10-10Canada
Nasacort AQspray, metered dose55 mcgnasalSanofi Aventis Canada Inc1996-12-31Not applicableCanada
Nasacort AQspray, metered55 ug/1nasalSanofi Aventis U.S. Llc1996-05-20Not applicableUs
Oracort Dental Paste 0.1%paste.1 %dentalTaro Pharmaceuticals Inc1992-12-31Not applicableCanada
Scheinpharm Triamcine-A Inject.sus-40mg/mlsuspension40 mgintramuscularSchein Pharmaceutical Canada Inc.1996-09-202004-07-26Canada
Triaderm Crm 0.025%cream.025 %topicalTaro Pharmaceuticals Inc1979-12-31Not applicableCanada
Triaderm Crm 0.1%cream0.1 %topicalTaro Pharmaceuticals Inc1979-12-31Not applicableCanada
Triaderm Ont 0.025%ointment0.25 mgtopicalTaro Pharmaceuticals Inc1979-12-312001-08-21Canada
Triaderm Ont 0.1%ointment1 mgtopicalTaro Pharmaceuticals Inc1988-12-31Not applicableCanada
Triamcinolone Acetonidespray, metered55 ug/1nasalWinthrop U.S.2011-06-15Not applicableUs
Triamcinolone Acetonide Injectable Suspension USPsuspension40 mgintra-articular; intrabursal; intramuscularSandoz Canada Incorporated1997-03-26Not applicableCanada
Triamcinolone Acetonide Injectable Suspension USPsuspension10 mgintra-articular; intrabursal; intradermal; intrasynovialSandoz Canada Incorporated1997-03-26Not applicableCanada
Triamcinolone Acetonide Suspensionsuspension40 mgintra-articular; intramuscularSterimax Inc1993-12-31Not applicableCanada
Triamcinolone Acetonide Suspensionsuspension40 mgintra-articular; intramuscularSterimax Inc1993-12-31Not applicableCanada
Triamcinolone Diacetate Sus 40mg/mlsuspension40 mgintralesionalTaro Pharmaceuticals Inc1980-12-312001-08-21Canada
Triamcinolone Diacetate Suspensionsuspension40 mgintra-articular; intradermal; intralesional; intramuscularSterimax Inc1992-11-19Not applicableCanada
Triesencesuspension40 mgintravitrealAlcon Canada Inc2012-08-22Not applicableCanada
Triesenceinjection, suspension40 mg/mLophthalmicAlcon Laboratories, Inc.2007-11-15Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-triamcinolone AQspray, metered dose55 mcgnasalApotex IncNot applicableNot applicableCanada
Dermacinrx Silazone PakkitPure Tek Corporation2015-12-10Not applicableUs
Dermasorb Ta Complete KitkitCrown Laboratories2013-11-14Not applicableUs
DermazonekitShoreline Pharmaceuticals, Inc.2016-04-20Not applicableUs
Oralonepaste1 mg/gdentalTaro Pharmaceuticals U.S.A., Inc.1986-10-01Not applicableUs
Pediaderm TakitArbor Pharmaceuticals, Inc.2011-01-01Not applicableUs
Pediaderm Tacream1 mg/gtopicalArbor Pharmaceuticals, Inc.2010-09-01Not applicableUs
Silazone-IIkitPure Tek Corporation2016-01-20Not applicableUs
Triamcinolone Acetonideointment.25 mg/gtopicalG&W Laboratories, Inc.2015-09-10Not applicableUs
Triamcinolone Acetonideointment1 mg/gtopicalPhysicians Total Care, Inc.2006-09-18Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalA S Medication Solutions Llc1978-03-09Not applicableUs
Triamcinolone Acetonideointment5 mg/gtopicalProficient Rx LP2006-11-10Not applicableUs
Triamcinolone Acetonidespray, metered55 ug/1nasalTeva Pharmaceuticals USA Inc2011-06-15Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalH.J. Harkins Company, Inc.2006-09-28Not applicableUs
Triamcinolone Acetonidelotion.25 mg/mLtopicalVersa Pharm Incorporated2013-05-21Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalREMEDYREPACK INC.2013-12-03Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalUnit Dose Services1978-03-09Not applicableUs
Triamcinolone Acetonidepaste1 mg/gdentalPhysicians Total Care, Inc.2003-09-03Not applicableUs
Triamcinolone Acetonideointment.5 mg/gtopicalCarolina Medical Products Company1995-03-23Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalPreferred Pharmaceuticals, Inc.2008-06-10Not applicableUs
Triamcinolone Acetonideaerosol, spray.147 mg/gtopicalPerrigo New York Inc2015-04-17Not applicableUs
Triamcinolone Acetonidepaste1 mg/gtopicalRising Pharmaceuticals, Inc.2010-07-07Not applicableUs
Triamcinolone Acetonidepaste1 mg/gtopicalAv Kare, Inc.2012-03-28Not applicableUs
Triamcinolone Acetonideointment1 mg/gtopicalRebel Distributors Corp2009-10-07Not applicableUs
Triamcinolone Acetonidelotion1 mg/mLtopicalG&W Laboratories, Inc.2015-04-01Not applicableUs
Triamcinolone Acetonideointment1 mg/gtopicalG&W Laboratories, Inc.2015-09-10Not applicableUs
Triamcinolone Acetonideointment.25 mg/gtopicalPhysicians Total Care, Inc.1994-11-22Not applicableUs
Triamcinolone Acetonidelotion1 mg/mLtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2003-04-21Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalA S Medication Solutions Llc1978-03-09Not applicableUs
Triamcinolone Acetonidecream.025 mg/gtopicalProficient Rx LP1978-03-09Not applicableUs
Triamcinolone Acetonidelotion1 mg/mLtopicalMorton Grove Pharmaceuticals, Inc.1985-04-03Not applicableUs
Triamcinolone Acetonidecream1 mg/1topicalREMEDYREPACK INC.2013-04-12Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalUnit Dose Services2012-04-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalMedsource Pharmaceuticals2012-04-01Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalPreferred Pharmaceuticals, Inc.2014-08-20Not applicableUs
Triamcinolone Acetonideointment.25 mg/gtopicalRebel Distributors Corp2009-10-07Not applicableUs
Triamcinolone Acetonideointment.25 mg/gtopicalRebel Distributors Corp2009-10-07Not applicableUs
Triamcinolone Acetonidelotion1 mg/mLtopicalQualitest Pharmaceuticals2006-12-13Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalPhysicians Total Care, Inc.1994-11-22Not applicableUs
Triamcinolone Acetonidelotion.25 mg/mLtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2003-04-21Not applicableUs
Triamcinolone Acetonideointment1 mg/gtopicalA S Medication Solutions Llc1978-02-14Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalProficient Rx LP1978-03-09Not applicableUs
Triamcinolone Acetonidelotion.25 mg/mLtopicalMorton Grove Pharmaceuticals, Inc.1985-04-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalREMEDYREPACK INC.2013-06-13Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalCentral Texas Community Health Centers2006-09-28Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalPerrigo New York Inc2006-05-17Not applicableUs
Triamcinolone Acetonideointment5 mg/gtopicalDispensing Solutions, Inc.2006-11-10Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1997-11-26Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalRebel Distributors Corp1978-03-09Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalQualitest Pharmaceuticals2006-06-09Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalPhysicians Total Care, Inc.1995-02-22Not applicableUs
Triamcinolone Acetonideointment1 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1978-02-14Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalA S Medication Solutions Llc1978-03-09Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalProficient Rx LP2012-04-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalPerrigo New York Inc2006-09-28Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalAscend Laboratories, LLC2012-04-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1978-03-09Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalRebel Distributors Corp1978-03-09Not applicableUs
Triamcinolone Acetonideointment1 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1994-09-30Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalPerrigo New York Inc2006-10-09Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalAscend Laboratories, LLC2012-04-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalRebel Distributors Corp1978-03-09Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalQualitest Pharmaceuticals2006-06-09Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalPhysicians Total Care, Inc.1995-02-22Not applicableUs
Triamcinolone Acetonideointment.25 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1978-02-14Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalA S Medication Solutions Llc1978-03-09Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalDIRECT RX2014-01-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalClinical Solutions Wholesale2012-04-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalSTAT RX LLC USA1981-04-09Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalA S Medication Solutions Llc1978-03-09Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1978-03-09Not applicableUs
Triamcinolone Acetonideointment1 mg/gtopicalA S Medication Solutions Llc1978-02-14Not applicableUs
Triamcinolone Acetonideointment5 mg/gtopicalREMEDYREPACK INC.2015-03-02Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalLake Erie Medical DBA Quality Care Products LLC2012-04-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1997-11-26Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalG&W Laboratories, Inc.2015-04-14Not applicableUs
Triamcinolone Acetonideointment1 mg/gtopicalPerrigo New York Inc2006-08-04Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalAscend Laboratories, LLC2012-04-01Not applicableUs
Triamcinolone Acetonidepaste1 mg/gtopicalA S Medication Solutions Llc2010-07-07Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1978-03-09Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalA S Medication Solutions Llc1978-03-09Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalREMEDYREPACK INC.2014-09-10Not applicableUs
Triamcinolone Acetonidespray, metered55 ug/1nasalPhysicians Total Care, Inc.2011-09-14Not applicableUs
Triamcinolone Acetonidepaste1 mg/gdentalTaro Pharmaceuticals U.S.A., Inc.1986-10-01Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalG&W Laboratories, Inc.2015-04-14Not applicableUs
Triamcinolone Acetonideointment.25 mg/gtopicalPerrigo New York Inc2006-05-12Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalArbor Pharmaceuticals Inc.1997-11-26Not applicableUs
Triamcinolone Acetonideinjection, suspension40 mg/mLintra-articular; intramuscularSandoz Inc2009-05-27Not applicableUs
Triamcinolone Acetonideointment.25 mg/gtopicalA S Medication Solutions Llc2006-05-12Not applicableUs
Triamcinolone Acetonidecream5 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1978-03-09Not applicableUs
Triamcinolone Acetonidecream.25 mg/gtopicalAidarex Pharmaceuticals LLC2006-06-09Not applicableUs
Triamcinolone Acetonidelotion1 mg/mLtopicalVersa Pharm Incorporated2013-05-21Not applicableUs
Triamcinolone Acetonidelotion1 mg/mLtopicalPhysicians Total Care, Inc.2005-01-26Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-20Not applicableUs
Triamcinolone Acetonidecream1 mg/gtopicalPreferred Pharmaceuticals, Inc2012-02-14Not applicableUs
Triamcinolone Acetonideointment5 mg/gtopicalPerrigo New York Inc2006-11-10Not applicableUs
Triamcinolone Acetonidespray, metered55 ug/1nasalMed Vantx, Inc.2011-04-06Not applicableUs
Triamcinolone Acetonidepaste1 mg/gtopicalRebel Distributors Corp2010-07-07Not applicableUs
Triamcinolone Acetonideinjection, suspension10 mg/mLintra-articular; intrabursal; intradermal; intralesionalSandoz Inc2009-05-27Not applicableUs
Trianexointment.5 mg/gtopicalUpsher Smith Laboratories, Inc.2011-05-27Not applicableUs
Trianex 0.05%ointment.5 mg/gtopicalPromius Pharma, LLC2015-02-18Not applicableUs
Tridermcream5 mg/gtopicalCrown Laboratories1984-03-19Not applicableUs
Tridermcream1 mg/gtopicalCrown Laboratories1984-03-19Not applicableUs
Tridermcream.25 mg/gtopicalCrown Laboratories1984-03-19Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Nasal Allergyspray, suspension55 ug/1nasalKroger Company2016-04-10Not applicableUs
Allergy Nasalspray, suspension55 ug/1nasalWalgreen Company2016-04-10Not applicableUs
Childrens Nasacort Allergy 24hrspray, metered55 ug/1nasalChattem, Inc.2015-07-01Not applicableUs
Equate Nasal Allergyspray, suspension55 ug/1nasalWal Mart Stores Inc2016-04-17Not applicableUs
Nasacort Allergy 24hrspray, metered55 ug/1nasalChattem, Inc.2014-02-03Not applicableUs
Nasacort Allergy 24hrspray, metered dose55 mcgnasalSanofi Aventis Canada Inc2015-07-06Not applicableCanada
Nasal Allergyspray, suspension55 ug/1nasalCVS Pharmacy2016-04-10Not applicableUs
Nasal Allergy 24 Hourspray, metered55 ug/1nasalGeiss, Destin & Dunn Inc.2015-06-19Not applicableUs
Nasal Spray Allergy 24hrspray, metered dose55 mcgnasalApotex IncNot applicableNot applicableCanada
Unapproved/Other Products Not Available
International Brands
NameCompany
AristocortNot Available
DelphicortNot Available
FlutexNot Available
KenacortNot Available
Omcilon-ANot Available
OracortNot Available
Tri-NasalNot Available
TriacetNot Available
TriacortNot Available
TriadermNot Available
TricortoneNot Available
TriloneNot Available
TristojectNot Available
Brand mixtures
NameLabellerIngredients
Aristoform R Crm 0.1%Lederle Cyanamid Canada Inc.
Kenacomb CreamWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb Mild CreamWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb Mild OintmentWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb OintmentWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb OntSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.
Mecomb Crm 0.1%Medic Laboratory LtÉe
Nystatin and TriamcinoloneSTAT RX LLC USA
Nystatin and Triamcinolone AcetonideE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
Physician Ez Use Joint Tunnel and Trigger KitAsclemed Usa, Inc.
Ratio-triacombTeva Canada Limited
Readysharp-KTerrain Pharmaceuticals
Theraderm CreamBimeda Mtc Animal Health Inc
Viaderm Kc CrmTaro Pharmaceuticals Inc
Viaderm Kc OntTaro Pharmaceuticals Inc
Salts
Name/CASStructureProperties
Triamcinolone acetonide
ThumbNot applicableDBSALT000860
Triamcinolone diacetate
ThumbNot applicableDBSALT000859
Triamcinolone hexacetonide
ThumbNot applicableDBSALT000861
Categories
UNII1ZK20VI6TY
CAS number124-94-7
WeightAverage: 394.4339
Monoisotopic: 394.179166801
Chemical FormulaC21H27FO6
InChI KeyInChIKey=GFNANZIMVAIWHM-OBYCQNJPSA-N
InChI
InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
IUPAC Name
(1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one
SMILES
[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[[email protected]](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • 21-hydroxysteroid
  • Progestogin-skeleton
  • Pregnane-skeleton
  • 20-oxosteroid
  • 17-hydroxysteroid
  • 16-hydroxysteroid
  • 11-hydroxysteroid
  • 16-alpha-hydroxysteroid
  • 11-beta-hydroxysteroid
  • Oxosteroid
  • Halo-steroid
  • 9-halo-steroid
  • 3-oxosteroid
  • 3-oxo-delta-1,4-steroid
  • Delta-1,4-steroid
  • Tertiary alcohol
  • Cyclic alcohol
  • Alpha-hydroxy ketone
  • Cyclic ketone
  • Secondary alcohol
  • Polyol
  • Ketone
  • Halohydrin
  • Fluorohydrin
  • 1,2-diol
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Organofluoride
  • Organohalogen compound
  • Carbonyl group
  • Alkyl halide
  • Alkyl fluoride
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of perennial and seasonal allergic rhinitis.
PharmacodynamicsTriamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.
Mechanism of actionThe antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Related Articles
AbsorptionRapid absorption following oral administration
Volume of distributionNot Available
Protein binding68%
Metabolism

Hepatic.

Route of eliminationNot Available
Half life88 minutes
ClearanceNot Available
ToxicityLD50=>500mg/kg (in rats)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9823
Blood Brain Barrier+0.9528
Caco-2 permeable+0.7397
P-glycoprotein substrateSubstrate0.8204
P-glycoprotein inhibitor INon-inhibitor0.8759
P-glycoprotein inhibitor IINon-inhibitor0.9725
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.8858
CYP450 2D6 substrateNon-substrate0.9006
CYP450 3A4 substrateSubstrate0.7049
CYP450 1A2 substrateNon-inhibitor0.9144
CYP450 2C9 inhibitorNon-inhibitor0.8939
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.911
CYP450 3A4 inhibitorNon-inhibitor0.9007
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.942
Ames testNon AMES toxic0.8858
CarcinogenicityNon-carcinogens0.9521
BiodegradationNot ready biodegradable0.9952
Rat acute toxicity2.3369 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9562
hERG inhibition (predictor II)Inhibitor0.6125
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Astellas pharma us inc
  • Bristol myers squibb co
  • Barr laboratories inc
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Abbott laboratories
  • Sanofi aventis us llc
  • Ivax pharmaceuticals inc
  • Apothecon inc div bristol myers squibb
  • Solvay pharmaceuticals
  • Actavis mid atlantic llc
  • Alpharma us pharmaceuticals division
  • Altana inc
  • Ambix laboratories div organics corp america
  • G and w laboratories inc
  • Morton grove pharmaceuticals inc
  • Perrigo new york inc
  • Pharmaderm div altana inc
  • Pharmafair inc
  • Taro pharmaceuticals inc
  • Taro pharmaceuticals usa inc
  • Topiderm inc
  • Vintage pharmaceuticals llc
  • Del ray laboratories inc
  • Savage laboratories inc div altana inc
  • Parnell pharmaceuticals inc
  • Sandoz canada inc
  • Allergan inc
  • Alcon inc
  • Bristol myers squibb co pharmaceutical research institute
  • Wockhardt eu operations (swiss) ag
  • Carolina medical products co
  • Lyne laboratories inc
  • Lupin atlantis holding sa switzerland
  • Ranbaxy laboratories inc
  • Akorn inc
Packagers
Dosage forms
FormRouteStrength
Spray, suspensionnasal55 ug/1
Spray, meterednasal.5 mg/mL
Syruporal.4 mg
Creamtopical0.5 %
Creamtopical5 mg
Creamtopical.25 mg
Liquidintra-articular; intramuscular; intrasynovial40 mg
Liquidintra-articular; intradermal; intramuscular25 mg
Ointmenttopical0.1 %
Creamtopical1 mg
Ointmenttopical.1 %
Syruporal2 mg
Tabletoral2 mg
Tabletoral4 mg
Injection, suspensionintra-articular; parenteral20 mg/mL
Injection, suspensionintralesional; parenteral5 mg/mL
Suspensionintra-articular20 mg
Metered-dose aerosolinhalation200 mcg
Kit
Aerosol, spraytopical.147 mg/g
Pastedental1 mg
Injection, suspensionintra-articular; intralesional10 mg/mL
Suspensionintra-articular; intrabursal; intradermal; intrasynovial10 mg
Injection, suspensionintra-articular; intramuscular40 mg/mL
Injection, suspensionintramuscular40 mg/mL
Injection, suspensionintramuscular40 mg/1
Suspensionintra-articular; intramuscular40 mg
Metered-dose aerosolnasal100 mcg
Spray, meterednasal55 ug/1
Spray, metered dosenasal55 mcg
Creamtopical
Ointmenttopical
Pastedental.1 %
Kit
Kitinfiltration; intra-articular; intramuscular; respiratory (inhalation); topical
Kitepidural; infiltration; intra-articular; intramuscular; topical
Suspensionintramuscular40 mg
Creamtopical.025 %
Creamtopical0.1 %
Ointmenttopical0.25 mg
Ointmenttopical1 mg
Creamtopical.025 mg/g
Creamtopical.25 mg/g
Creamtopical1 mg/1
Creamtopical1 mg/g
Creamtopical5 mg/g
Injection, suspensionintra-articular; intrabursal; intradermal; intralesional10 mg/mL
Lotiontopical.25 mg/mL
Lotiontopical1 mg/mL
Ointmenttopical.25 mg/g
Ointmenttopical1 mg/g
Ointmenttopical5 mg/g
Pastedental1 mg/g
Pastetopical1 mg/g
Suspensionintra-articular; intrabursal; intramuscular40 mg
Suspensionintralesional40 mg
Suspensionintra-articular; intradermal; intralesional; intramuscular40 mg
Ointmenttopical.5 mg/g
Injection, suspensionophthalmic40 mg/mL
Suspensionintravitreal40 mg
Prices
Unit descriptionCostUnit
Triesence 40 mg/ml vial148.8USD ml
Kenalog Aerosol 63 gm Can118.99USD can
Nasacort AQ 55 mcg/act Aerosol (Nasal Spray)118.74USD inhaler
Triamcinolone Acetonide 0.1% Paste 5 gm Tube71.7USD tube
Kenalog 0.5% Cream 20 gm Tube54.99USD tube
Kenalog 0.1% Lotion 60ml Bottle51.99USD bottle
Kenalog 0.025% Lotion 60ml Bottle46.99USD bottle
Triamcinolone Acetonide 0.025% Lotion 60ml Bottle40.99USD bottle
Triamcinolone diacetate powder26.01USD g
Triamcinolone powder20.29USD g
Kenalog 0.1% Cream 15 gm Tube18.99USD tube
Triamcinolone Acetonide 0.1% Ointment 80 gm Tube18.99USD tube
Triamcinolone Acetonide 0.5% Ointment 15 gm Tube14.99USD tube
Aristospan 20 mg/ml vial14.19USD ml
Oralone 0.1% paste13.57USD g
Triamcinolone Acetonide 0.025% Cream 80 gm Tube12.99USD tube
Triamcinolone Acetonide 0.1% Cream 80 gm Tube12.99USD tube
Triamcinolone Acetonide 0.5% Cream 15 gm Tube12.99USD tube
Triamcinolone Acetonide 0.025% Cream 15 gm Tube11.99USD tube
Triamcinolone Acetonide 0.025% Ointment 80 gm Tube11.99USD tube
Triamcinolone Acetonide 0.1% Cream 15 gm Tube11.99USD tube
Triamcinolone Acetonide 0.1% Ointment 15 gm Tube11.99USD tube
Kenalog-40 40 mg/ml vial8.99USD ml
Triamcinolone acet 40 mg/ml sus8.42USD ml
Kenalog-40 40 mg/ml7.53USD ml
Nasacort aq nasal spray6.99USD g
Triamcinolone 0.1% paste6.4USD g
Triamcinolone Acetonide 40 mg/ml6.29USD ml
Triamcinolone Acetonide Usp 40 mg/ml5.76USD ml
Aristospan 5 mg/ml vial3.54USD ml
Kenalog-10 10 mg/ml3.24USD ml
Triamcinolone Acetonide 10 mg/ml2.71USD ml
Kenalog-10 10 mg/ml vial2.32USD ml
Triamcinolone acet 10 mg/ml sus2.18USD ml
Aristocort C 0.5 % Cream1.3USD g
Oracort 0.1 % Paste1.19USD g
Triderm 0.1% cream0.47USD g
Triamcinolone 0.5% cream0.22USD g
Aristocort R 0.1 % Cream0.15USD g
Aristocort R 0.1 % Ointment0.15USD g
Triamcinolone Acetonide 0.1% Cream0.07USD gm
Triaderm Regular 0.1 % Cream0.07USD g
Triamcinolone 0.025% cream0.06USD g
Triamcinolone Acetonide 0.1% Ointment0.05USD gm
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2268927 No2003-09-232017-07-02Canada
US5976573 No1996-07-032016-07-03Us
US6143329 No1996-07-032016-07-03Us
US6395294 No2000-01-132020-01-13Us
US7977045 No1996-07-032016-07-03Us
US8128960 No2009-12-172029-12-17Us
US8211880 No2009-03-102029-03-10Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point270 °CPhysProp
water solubility80 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.16HANSCH,C ET AL. (1995)
logS-3.69ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.847 mg/mLALOGPS
logP0.84ALOGPS
logP0.24ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)11.75ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area115.06 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity99.38 m3·mol-1ChemAxon
Polarizability39.79 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (9.24 KB)
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-00di-2931000000-ee37afbf8c285181a340View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
References
Synthesis Reference

Abu Alam, “Triamcinolone formulations and methods for their preparation and use.” U.S. Patent US20040186084, issued September 23, 2004.

US20040186084
General ReferencesNot Available
External Links
ATC CodesA01AC01C05AA12D07AB09D07BB03D07CB01D07XB02H02AB08R01AD11R03BA06S01BA05S02CA04
AHFS Codes
  • 52:08.08
  • 68:04.00
  • 84:06.00
PDB EntriesNot Available
FDA labelDownload (150 KB)
MSDSDownload (72.6 KB)
Interactions
Drug Interactions
Drug
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Triamcinolone.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Triamcinolone.
AldesleukinTriamcinolone may decrease the antineoplastic activities of Aldesleukin.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Triamcinolone.
Amphotericin BTriamcinolone may increase the hypokalemic activities of Amphotericin B.
AprepitantThe serum concentration of Triamcinolone can be increased when it is combined with Aprepitant.
Atracurium besylateAtracurium besylate may increase the adverse neuromuscular activities of Triamcinolone.
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Triamcinolone.
CalcitriolThe therapeutic efficacy of Calcitriol can be decreased when used in combination with Triamcinolone.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Triamcinolone.
CapromabTriamcinolone may decrease effectiveness of Capromab as a diagnostic agent.
CeritinibTriamcinolone may increase the hyperglycemic activities of Ceritinib.
ChlorotrianiseneThe serum concentration of Triamcinolone can be increased when it is combined with Chlorotrianisene.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Triamcinolone.
Corticorelin ovine triflutateThe therapeutic efficacy of Corticorelin can be decreased when used in combination with Triamcinolone.
DeferasiroxThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Deferasirox.
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Triamcinolone.
DesmopressinThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Desmopressin.
DihydrotestosteroneTriamcinolone may increase the fluid retaining activities of Dihydrotestosterone.
FosaprepitantThe serum concentration of Triamcinolone can be increased when it is combined with Fosaprepitant.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Triamcinolone.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Triamcinolone.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Triamcinolone.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Triamcinolone.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Triamcinolone.
IcosapentThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Icosapent.
IndacaterolIndacaterol may increase the hypokalemic activities of Triamcinolone.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Triamcinolone.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Triamcinolone.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Triamcinolone.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Triamcinolone.
Insulin HumanThe therapeutic efficacy of Insulin Regular can be decreased when used in combination with Triamcinolone.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Triamcinolone.
IsoniazidThe serum concentration of Isoniazid can be decreased when it is combined with Triamcinolone.
LeflunomideThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Leflunomide.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Triamcinolone.
LopinavirThe risk or severity of adverse effects can be increased when Lopinavir is combined with Triamcinolone.
LoxapineThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Loxapine.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Triamcinolone.
MifepristoneThe therapeutic efficacy of Triamcinolone can be decreased when used in combination with Mifepristone.
MitotaneThe serum concentration of Triamcinolone can be decreased when it is combined with Mitotane.
NatalizumabThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Natalizumab.
NelfinavirThe serum concentration of Triamcinolone can be increased when it is combined with Nelfinavir.
NicorandilThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Nicorandil.
OxandroloneTriamcinolone may increase the fluid retaining activities of Oxandrolone.
PhenytoinThe serum concentration of Triamcinolone can be decreased when it is combined with Phenytoin.
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Triamcinolone.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Triamcinolone.
RitonavirThe risk or severity of adverse effects can be increased when Ritonavir is combined with Triamcinolone.
RoflumilastRoflumilast may increase the immunosuppressive activities of Triamcinolone.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Triamcinolone.
Sipuleucel-TThe therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Triamcinolone.
SparfloxacinThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Sparfloxacin.
TacrineThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Tacrine.
TacrolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Triamcinolone.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Triamcinolone.
TestosteroneTriamcinolone may increase the fluid retaining activities of Testosterone.
TofacitinibTriamcinolone may increase the immunosuppressive activities of Tofacitinib.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Triamcinolone.
TorasemideTriamcinolone may increase the hypokalemic activities of Torasemide.
TrastuzumabTrastuzumab may increase the neutropenic activities of Triamcinolone.
TrichlormethiazideTriamcinolone may increase the hypokalemic activities of Trichlormethiazide.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Triamcinolone.
WarfarinTriamcinolone may increase the anticoagulant activities of Warfarin.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon grow...
Gene Name:
NR3C1
Uniprot ID:
P04150
Molecular Weight:
85658.57 Da
References
  1. Nehme A, Lobenhofer EK, Stamer WD, Edelman JL: Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics. 2009 Sep 10;2:58. doi: 10.1186/1755-8794-2-58. [PubMed:19744340 ]
  2. Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. [PubMed:16507850 ]
  3. Shahin V, Ludwig Y, Schafer C, Nikova D, Oberleithner H: Glucocorticoids remodel nuclear envelope structure and permeability. J Cell Sci. 2005 Jul 1;118(Pt 13):2881-9. [PubMed:15976447 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Dort K, Padia S, Wispelwey B, Moore CC: Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report. AIDS Res Ther. 2009 Jun 8;6:10. doi: 10.1186/1742-6405-6-10. [PubMed:19505306 ]
  2. Hagan JB, Erickson D, Singh RJ: Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone. Pain Med. 2010 Jul;11(7):1132-5. doi: 10.1111/j.1526-4637.2010.00852.x. Epub 2010 Apr 29. [PubMed:20456080 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, p...
Gene Name:
PTGS2
Uniprot ID:
P35354
Molecular Weight:
68995.625 Da
References
  1. Schaefer EC, Stewart AA, Durgam SS, Byron CR, Stewart MC: Effects of sodium hyaluronate and triamcinolone acetonide on glucosaminoglycan metabolism in equine articular chondrocytes treated with interleukin-1. Am J Vet Res. 2009 Dec;70(12):1494-501. doi: 10.2460/ajvr.70.12.1494. [PubMed:19951121 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Identical protein binding
Specific Function:
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Gene Name:
BCHE
Uniprot ID:
P06276
Molecular Weight:
68417.575 Da
References
  1. Ehrich M, Jortner BS, Gross WB: Types of adrenocorticoids and their effect on organophosphorus-induced delayed neuropathy in chickens. Toxicol Appl Pharmacol. 1988 Feb;92(2):214-23. [PubMed:3341034 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Steroid binding
Specific Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name:
SERPINA6
Uniprot ID:
P08185
Molecular Weight:
45140.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Groyer A, Le Bouc Y, Joab I, Radanyi C, Renoir JM, Robel P, Baulieu EE: Chick oviduct glucocorticosteroid receptor. Specific binding of the synthetic steroid RU 486 and immunological studies with antibodies to chick oviduct progesterone receptor. Eur J Biochem. 1985 Jun 3;149(2):445-51. [PubMed:3996417 ]
  4. Svec F, Harrison RW: Conditions affecting AtT-20 cell glucocorticoid uptake. Steroids. 1981 Feb;37(2):143-56. [PubMed:7222146 ]
  5. Eisen HJ: An antiserum to the rat liver glucocorticoid receptor. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3893-7. [PubMed:7001446 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on June 28, 2016 01:51