Showing BioInteractions for Pemetrexed (DB00642)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Pemetrexed is a Thymidylate synthase inhibitor
1	Thymidylate synthase inhibitors	Capecitabine, Gemcitabine, Methotrexate, Pralatrexate, Raltitrexed, Tegafur, Trifluridine
2	Thymidylate synthase substrates	Fluorouracil, Methotrexate
3	Thymidylate synthase antagonists	Tegafur-uracil

	Interacting Group	Interacting Drugs
	Pemetrexed is a Dihydrofolate reductase inhibitor
1	Dihydrofolate reductase inhibitors	Aminopterin, Lamotrigine, Methotrexate, Pralatrexate, Proguanil, Pyrimethamine, Trimetrexate
2	Dihydrofolate reductase substrates	Folic acid, Methotrexate, Trimetrexate

	Interacting Group	Interacting Drugs
	Pemetrexed is a Trifunctional purine biosynthetic protein adenosine-3 inhibitor

	Interacting Group	Interacting Drugs
	Pemetrexed is a Bifunctional purine biosynthesis protein PURH inhibitor
1	Bifunctional purine biosynthesis protein PURH cofactors	Tetrahydrofolic acid
2	Bifunctional purine biosynthesis protein PURH inhibitors	Methotrexate

	Interacting Group	Interacting Drugs
	Pemetrexed is a Deoxycytidine kinase inducer
1	Deoxycytidine kinase substrates	2'-Deoxycytidine, Cladribine, Clofarabine, Cytarabine, Decitabine, Emtricitabine, Gemcitabine, Lamivudine, Nelarabine, Zalcitabine
2	Deoxycytidine kinase agonists	Fludarabine
3	Deoxycytidine kinase activators	Troxacitabine

	Interacting Group	Interacting Drugs
	Pemetrexed is a Equilibrative nucleoside transporter 1 inducer
1	Equilibrative nucleoside transporter 1 inhibitors	Cannabidiol, Fostamatinib, Medical Cannabis, Nabiximols, Troglitazone
2	Equilibrative nucleoside transporter 1 substrates	Adenosine, Cytarabine, Fludarabine, Fluorouracil, Gemcitabine, Mercaptopurine, Ribavirin, Tegafur-uracil, Trifluridine

	Interacting Group	Interacting Drugs
	Pemetrexed is a Solute carrier family 22 member 8 substrate
1	Solute carrier family 22 member 8 inhibitors	Acetylsalicylic acid, Acyclovir, Aminohippuric acid, Apalutamide, Artesunate, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Favipiravir, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Hydroflumethiazide, Ibuprofen, Indomethacin, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Novobiocin, Osilodrostat, Ouabain, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rimegepant, Rosuvastatin, Rucaparib, Salicylic acid, Tafamidis, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Valproic acid, Zidovudine
2	Solute carrier family 22 member 8 inducers	Methyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3	Solute carrier family 22 member 8 substrates	Acamprosate, Acyclovir, Allopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Betamethasone phosphate, Budesonide, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cortisone acetate, Cyclic adenosine monophosphate, Dexamethasone, Dexamethasone acetate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Empagliflozin, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Hydroflumethiazide, Leucovorin, Levocarnitine, Medrysone, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Oxytetracycline, Piperacillin, Polythiazide, Pravastatin, Prednisolone phosphate, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Valproic acid, Zidovudine