Showing BioInteractions for Mebendazole (DB00643)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 2
Enzyme Mediated Interactions 2

	Interacting Group	Interacting Drugs
	Mebendazole is a Tubulin alpha-1A chain inhibitor
1	Tubulin alpha-1A chain inhibitors	Albendazole
2	Tubulin alpha-1A chain ligands	Artenimol
3	Tubulin alpha-1A chain binders	Colchiceine

	Interacting Group	Interacting Drugs
	Mebendazole is a Tubulin beta-4B chain inhibitor
1	Tubulin beta-4B chain inhibitors	Albendazole

	Interacting Group	Interacting Drugs
	Mebendazole is a Cytochrome P450 1A1 inducer
1	Cytochrome P450 1A1 substrates	(R)-warfarin, Amiodarone, Amodiaquine, Azelastine, Azimilide, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Copanlisib, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquine, Difloxacin, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Istradefylline, Loratadine, Lorcaserin, Melatonin, Nicotine, Omeprazole, Pentamidine, Perospirone, Phenacetin, Pioglitazone, Progesterone, Resveratrol, Riluzole, Riociguat, Risdiplam, Romidepsin, Solifenacin, Tamoxifen, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Theophylline, Toremifene, Tretinoin, Triclabendazole
2	Cytochrome P450 1A1 inhibitors	Amlodipine, Azelastine, Benzyl alcohol, Caffeine, Cannabidiol, Cholecalciferol, Dexamethasone, Dexamethasone acetate, Dexmedetomidine, Ellagic acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Ketoconazole, Manidipine, Medical Cannabis, Melatonin, Menadione, Methoxsalen, Nabiximols, Nifedipine, Nitroprusside, Norfloxacin, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Safinamide, Sulindac, Theophylline, Topiroxostat
3	Cytochrome P450 1A1 inducers	Albendazole, Bezafibrate, Clofibrate, Clozapine, Dexamethasone, Dexamethasone acetate, Dovitinib, Ellagic acid, Fluvastatin, Itraconazole, Ketoconazole, Lansoprazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Picrotoxin, Primaquine, Propylthiouracil, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Triclocarban, Troglitazone

	Interacting Group	Interacting Drugs
	Mebendazole is a Cytochrome P450 3A Subfamily substrate
1	Cytochrome P450 3A Subfamily inhibitors	Crizotinib, Diacerein, Fluvoxamine, Glecaprevir, Istradefylline, Lemborexant, Lonafarnib, Lopinavir, Lorlatinib, Midostaurin, Nefazodone, Olanzapine, Phenelzine, Pibrentasvir, Remoxipride, Rhein, Risdiplam, Selpercatinib
2	Cytochrome P450 3A Subfamily substrates	Acalabrutinib, Ambroxol acefyllinate, Budesonide, Dolutegravir, Ebastine, Elagolix, Ethosuximide, Foretinib, Glecaprevir, Lonafarnib, Lorlatinib, Loxoprofen, Methylprednisolone, Midostaurin, Mirodenafil, Moxisylyte, Naldemedine, Omega-3-carboxylic acids, Relugolix, Tazemetostat, Thiopental, Tucatinib, Zanubrutinib
3	Cytochrome P450 3A Subfamily inducers	Brigatinib, Budesonide, Lemborexant, Methylprednisolone, Midostaurin, Myrrh, Prednisolone phosphate, Prednisone, Relugolix, Rifapentine, Ursodeoxycholic acid