Showing BioInteractions for Procaine (DB00721)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Procaine is a Sodium channel protein type 10 subunit alpha inhibitor
1	Sodium channel protein type 10 subunit alpha inhibitors	Benzocaine, Bupivacaine, Chloroprocaine, Cinchocaine, Dyclonine, Hexylcaine, Levobupivacaine, Lidocaine, Mepivacaine, Orphenadrine, Oxybuprocaine, Proparacaine, Ropivacaine

	Interacting Group	Interacting Drugs
	Procaine is a Glutamate receptor ionotropic, NMDA 3A antagonist
1	Glutamate receptor ionotropic, NMDA 3A antagonists	Amantadine, Dextromethorphan, Ethanol, Halothane, Ketamine, Orphenadrine, Phencyclidine, Profenamine, Tenocyclidine
2	Glutamate receptor ionotropic, NMDA 3A activators	Acetylcysteine

	Interacting Group	Interacting Drugs
	Procaine is a 5-hydroxytryptamine receptor 3A antagonist
1	5-hydroxytryptamine receptor 3A antagonists	Alosetron, Amoxapine, Aripiprazole, Cannabidiol, Clozapine, Dolasetron, Granisetron, Memantine, Methadone, Metoclopramide, Olanzapine, Ondansetron, Palonosetron, Ramosetron, Rocuronium, Tropisetron, Tubocurarine, Vortioxetine
2	5-hydroxytryptamine receptor 3A agonists	Cisapride
3	5-hydroxytryptamine receptor 3A ligands	Quetiapine
4	5-hydroxytryptamine receptor 3A binders	Loxapine, Trimipramine
5	5-hydroxytryptamine receptor 3A inhibitors	Lamotrigine
6	5-hydroxytryptamine receptor 3A potentiators	Ketamine
7	5-hydroxytryptamine receptor 3A negative modulators	Bupropion

	Interacting Group	Interacting Drugs
	Procaine is a Sodium-dependent dopamine transporter inhibitor
1	Sodium-dependent dopamine transporter inhibitors	4-Methoxyamphetamine, Armodafinil, Benzatropine, Benzphetamine, Bupropion, Chloroprocaine, Chlorpheniramine, Cocaine, Desvenlafaxine, Dexmethylphenidate, Diethylpropion, Diphenylpyraline, Duloxetine, Escitalopram, Etoperidone, Fencamfamin, Imipramine, Mazindol, Meperidine, Methylphenidate, Modafinil, Nefazodone, Phenmetrazine, Phentermine, Procaine, Pseudoephedrine, Sertraline, Sibutramine, Trimipramine, Venlafaxine
2	Sodium-dependent dopamine transporter negative modulators	Amphetamine, Dextroamphetamine, Ephedra sinica root, Metamfetamine, Midomafetamine, MMDA
3	Sodium-dependent dopamine transporter binders	Amoxapine, Loxapine, Mianserin, Sertraline
4	Sodium-dependent dopamine transporter inducers	Dopamine
5	Sodium-dependent dopamine transporter antagonists	Armodafinil
6	Sodium-dependent dopamine transporter modulators	Aripiprazole

	Interacting Group	Interacting Drugs
	Procaine is a Neuronal acetylcholine receptor subunit alpha-2 antagonist
1	Neuronal acetylcholine receptor subunit alpha-2 agonists	Carbamoylcholine, Epibatidine, Nicotine
2	Neuronal acetylcholine receptor subunit alpha-2 antagonists	Atracurium besylate, Cisatracurium, Dextromethorphan, Doxacurium, Fluoxetine, Gallamine triethiodide, Hexamethonium, Mecamylamine, Metocurine, Metocurine iodide, Mivacurium, Pancuronium, Pipecuronium, Rocuronium, Tubocurarine, Vecuronium
3	Neuronal acetylcholine receptor subunit alpha-2 partial agonists	Decamethonium

	Interacting Group	Interacting Drugs
	Procaine is a DNA (cytosine-5)-methyltransferase 1 inhibitor
1	DNA (cytosine-5)-methyltransferase 1 inhibitors	Azacitidine, Decitabine, Epigallocatechin gallate

	Interacting Group	Interacting Drugs
	Procaine is a Calcium-activated potassium channel blocker
1	Calcium-activated potassium channel inhibitors	Miconazole, Trimebutine

	Interacting Group	Interacting Drugs
	Procaine is a Cytosolic phospholipase A2 inhibitor
1	Cytosolic phospholipase A2 inhibitors	Carbenicillin, Epirubicin, Fluticasone, Fluticasone propionate, Lancovutide, Orlistat, Quinacrine, Suramin
2	Cytosolic phospholipase A2 inducers	Aldesleukin, Carbamoylcholine, Streptokinase
3	Cytosolic phospholipase A2 substrates	Urethane

	Interacting Group	Interacting Drugs
	Procaine is a 60 kDa lysophospholipase inhibitor

	Interacting Group	Interacting Drugs
	Procaine is a Monoamine oxidase inhibitor
1	Monoamine oxidase inhibitors	Amphetamine, Procarbazine
2	Monoamine oxidase cofactors	Copper
3	Monoamine oxidase antagonists	Moclobemide
4	Monoamine oxidase substrates	Betahistine, Epinephrine, Escitalopram, Rauwolfia serpentina root

	Interacting Group	Interacting Drugs
	Procaine is a DNA (cytosine-5)-methyltransferase 3A inhibitor
1	DNA (cytosine-5)-methyltransferase 3A inhibitors	Decitabine

	Interacting Group	Interacting Drugs
	Procaine is a Cholinesterase substrate
1	Cholinesterase inhibitors	Ambenonium, Aprotinin, Bambuterol, Betaine, Capsaicin, Chlorpromazine, Cinchocaine, Cisplatin, Decamethonium, Demecarium, Diethylcarbamazine, Echothiophate, Edrophonium, Galantamine, Hexafluronium, Isoflurophate, Ketamine, Malathion, Mechlorethamine, Mefloquine, Methylphosphinic Acid, Neostigmine, Nizatidine, Pancuronium, Pegvisomant, Perindopril, Phenserine, Pipecuronium, Procainamide, Profenamine, Ramipril, Regramostim, Rivastigmine, Sulpiride, Tacrine, Terbutaline, Thiotepa, Tretamine, Triflupromazine
2	Cholinesterase substrates	Aclidinium, Bambuterol, Benzonatate, Butamben, Butyrylthiocholine, Chloroprocaine, Clevidipine, Cocaine, Cyclopentolate, Dipivefrin, Doxacurium, Ephedrine, Irinotecan, Mirabegron, Moxisylyte, Oxybuprocaine, Propacetamol, Sar9, Met (O2)11-Substance P, Succinylcholine, Trimethaphan, Tubocurarine
3	Cholinesterase ligands	Butyric Acid, Ethyl dihydrogen phosphate, Phosphorylisopropane
4	Cholinesterase antagonists	Pyridostigmine
5	Cholinesterase activators	Pralidoxime
6	Cholinesterase inducers	Chlorphenesin, Donepezil, Pentagastrin, Triamcinolone

	Interacting Group	Interacting Drugs
	Procaine is a Cholinesterase inhibitor
1	Cholinesterase inhibitors	Ambenonium, Aprotinin, Bambuterol, Betaine, Capsaicin, Chlorpromazine, Cinchocaine, Cisplatin, Decamethonium, Demecarium, Diethylcarbamazine, Echothiophate, Edrophonium, Galantamine, Hexafluronium, Isoflurophate, Ketamine, Malathion, Mechlorethamine, Mefloquine, Methylphosphinic Acid, Neostigmine, Nizatidine, Pancuronium, Pegvisomant, Perindopril, Phenserine, Pipecuronium, Procainamide, Profenamine, Ramipril, Regramostim, Rivastigmine, Sulpiride, Tacrine, Terbutaline, Thiotepa, Tretamine, Triflupromazine
2	Cholinesterase substrates	Aclidinium, Bambuterol, Benzonatate, Butamben, Butyrylthiocholine, Chloroprocaine, Clevidipine, Cocaine, Cyclopentolate, Dipivefrin, Doxacurium, Ephedrine, Irinotecan, Mirabegron, Moxisylyte, Oxybuprocaine, Propacetamol, Sar9, Met (O2)11-Substance P, Succinylcholine, Trimethaphan, Tubocurarine
3	Cholinesterase ligands	Butyric Acid, Ethyl dihydrogen phosphate, Phosphorylisopropane
4	Cholinesterase antagonists	Pyridostigmine
5	Cholinesterase activators	Pralidoxime
6	Cholinesterase inducers	Chlorphenesin, Donepezil, Pentagastrin, Triamcinolone

	Interacting Group	Interacting Drugs
	Procaine is a Sodium-dependent dopamine transporter inhibitor
1	Sodium-dependent dopamine transporter inhibitors	4-Methoxyamphetamine, Armodafinil, Benzatropine, Benzphetamine, Bupropion, Chloroprocaine, Chlorpheniramine, Cocaine, Desvenlafaxine, Dexmethylphenidate, Diethylpropion, Diphenylpyraline, Duloxetine, Escitalopram, Etoperidone, Fencamfamin, Imipramine, Mazindol, Meperidine, Methylphenidate, Modafinil, Nefazodone, Phenmetrazine, Phentermine, Procaine, Pseudoephedrine, Sertraline, Sibutramine, Trimipramine, Venlafaxine
2	Sodium-dependent dopamine transporter negative modulators	Amphetamine, Dextroamphetamine, Ephedra sinica root, Metamfetamine, Midomafetamine, MMDA
3	Sodium-dependent dopamine transporter binders	Amoxapine, Loxapine, Mianserin, Sertraline
4	Sodium-dependent dopamine transporter inducers	Dopamine
5	Sodium-dependent dopamine transporter antagonists	Armodafinil
6	Sodium-dependent dopamine transporter modulators	Aripiprazole

	Interacting Group	Interacting Drugs
	Procaine is a Sodium-dependent noradrenaline transporter inhibitor
1	Sodium-dependent noradrenaline transporter inhibitors	Amitriptyline, Amoxapine, Atomoxetine, Benzatropine, Bupropion, Chlorpheniramine, Clomipramine, Cocaine, Cyclobenzaprine, Desipramine, Desvenlafaxine, Dexmethylphenidate, Dextromethorphan, Diethylpropion, Dopamine, Dosulepin, Doxepin, Duloxetine, Escitalopram, Etoperidone, Ginkgo biloba, Imipramine, Ketamine, Levomilnacipran, Maprotiline, Mazindol, Meperidine, Methylphenidate, Mianserin, Milnacipran, Nefazodone, Netarsudil, Nortriptyline, Orphenadrine, Paroxetine, Phenmetrazine, Phentermine, Protriptyline, Pseudoephedrine, Rauwolfia serpentina root, Reboxetine, Sertraline, Sibutramine, Tapentadol, Tramadol, Trimipramine, Venlafaxine, Viloxazine
2	Sodium-dependent noradrenaline transporter partial agonists	Guanadrel
3	Sodium-dependent noradrenaline transporter inducers	Debrisoquine, Guanethidine
4	Sodium-dependent noradrenaline transporter negative modulators	Dextroamphetamine, Ephedra sinica root, Metamfetamine, Midomafetamine, MMDA, Phendimetrazine
5	Sodium-dependent noradrenaline transporter inverse agonists	Ephedrine
6	Sodium-dependent noradrenaline transporter substrates	Droxidopa, Iobenguane, Iobenguane sulfate I-123, Norepinephrine, Nortriptyline
7	Sodium-dependent noradrenaline transporter binders	Loxapine
8	Sodium-dependent noradrenaline transporter stimulators	Amphetamine
9	Sodium-dependent noradrenaline transporter blockers	Vortioxetine
10	Sodium-dependent noradrenaline transporter antagonists	Zotepine

	Interacting Group	Interacting Drugs
	Procaine is a Sodium-dependent serotonin transporter inhibitor
1	Sodium-dependent serotonin transporter inhibitors	4-Methoxyamphetamine, Amitriptyline, Amoxapine, Benzatropine, Butriptyline, Chlorpheniramine, Citalopram, Clomipramine, Cocaine, Cyclobenzaprine, Desipramine, Desvenlafaxine, Dexfenfluramine, Dexmethylphenidate, Dextromethorphan, Dopamine, Dosulepin, Doxepin, Duloxetine, Escitalopram, Etoperidone, Fenfluramine, Fluoxetine, Fluvoxamine, Imipramine, Levomilnacipran, Lumateperone, Mazindol, Mianserin, Milnacipran, Minaprine, Mirtazapine, Nefazodone, Nortriptyline, Paroxetine, Phentermine, Protriptyline, Pseudoephedrine, Sertraline, Sibutramine, Tapentadol, Tegaserod, Tramadol, Trazodone, Trimipramine, Venlafaxine, Vilazodone, Vortioxetine
2	Sodium-dependent serotonin transporter binders	Amphetamine, Atomoxetine, Loxapine, Sertraline
3	Sodium-dependent serotonin transporter negative modulators	Ephedra sinica root, Metamfetamine, Midomafetamine, MMDA
4	Sodium-dependent serotonin transporter substrates	Fenfluramine, Mirtazapine, Tegaserod
5	Sodium-dependent serotonin transporter bindings	Meperidine
6	Sodium-dependent serotonin transporter antagonists	Butriptyline, Lorpiprazole, Zotepine
7	Sodium-dependent serotonin transporter modulators	Aripiprazole