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Showing drug card for Menthol (DB00825)

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Version 2.5
Creation Date 2005-06-13 13:24:05
Update Date 2009-04-16 16:48:02
Primary Accession Number DB00825
Secondary Accession Number
  • APRD01604
Name Menthol
Drug Type
  • Approved
  • Small Molecule
Description Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (-)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.
Synonyms
  1. (-)-menthol
  2. (r)-(-)-menthol
  3. L-(-)-menthol
  4. L-menthol
  5. Levomenthol
Brand Names Not Available
Brand Mixtures
  1. A.P.R 15 (lidocaine hydrochloride + menthol)
  2. Absorbine JR antifungal liq (menthol + tolnaftate)
  3. Absorbine JR extra strength liniment (chloroxylenol + menthol)
  4. Absorbine analgesic creme (camphor + eucalyptus oil + menthol + methyl salicylate)
  5. Absorbine arthritis strength liquid (capsicum + menthol)
  6. Absorbine junior patch (camphor + eucalyptus oil + menthol)
  7. Absorbine power gel (chloroxylenol + menthol)
  8. Acti bleu lotion (camphor + menthol + methyl salicylate)
  9. Acti poultice (eucalyptus oil + magnesium sulfate + menthol + methyl salicylate + thymol)
  10. Acti vapo (camphor + eucalyptus oil + menthol)
  11. Adult formula (belladonna + bryonia + drosera rotundifolia + ipecac + menthol + oil of turpentine + peppermint + spongia tosta + sticta pulmonaria + wild thyme)
  12. Amber mouthwash - liq (eucalyptol + menthol + thymol)
  13. Amol (cinnamon oil + clove oil + lavender oil + menthol + myristica oil + oil of citronella + oil of lemon + peppermint oil)
  14. Analgesic sport stick (menthol + methyl salicylate)
  15. Anbesol liquid (benzocaine + camphor + menthol + phenol)
  16. Anifen cough DPS (fennel oil + menthol + oil of anise)
  17. Antiseptic mouth rinse - liq (eucalyptol + menthol + thymol)
  18. Antiseptic mouthwash cool mint (eucalyptol + menthol + thymol)
  19. Antiseptic mouthwash mint (eucalyptol + menthol + thymol)
  20. Arthricare for women nighttime (menthol + methyl nicotinate + methyl salicylate)
  21. Arthricare for women ultra strength (capsaicin (capsicum oleoresin) + menthol)
  22. Arthriflex (eucalyptol + menthol)
  23. Arthritis pain reliever herbalife (camphor + menthol + methyl salicylate)
  24. Arthro rheuma cream (camphor + menthol)
  25. Arthrocare lotion (camphor + eucalyptus oil + histamine dihydrochloride + menthol + methyl salicylate)
  26. Artrikor creme analgesique (camphor + capsaicin + eucalyptus oil + menthol)
  27. Artritol creme rubefiante (menthol + methyl salicylate)
  28. Avon healthy remedies menthol & camphor soothing relief gel (camphor + menthol)
  29. Balminil camphorub (camphor + eucalyptol + menthol)
  30. Balminil nasal ointment (camphor + chlorobutanol + ephedrine hydrochloride + eucalyptol + l-menthol)
  31. Banana boat sooth-a-caine spray gel (lidocaine + menthol)
  32. Baumodyne gel (menthol + methyl salicylate)
  33. Beech nut black cough drop (menthol + oil of anise)
  34. Beech nut black cough drops (menthol + oil of anise)
  35. Beech nut honey lemon cough drop (eucalyptus oil + menthol)
  36. Beech nut honey lemon cough drops (eucalyptus + menthol)
  37. Beech nut menthol cough drop (anethole + eucalyptus oil + menthol)
  38. Beech nut wild cherry cough DPS (eucalyptus oil + menthol)
  39. Beech nut wild cherry cough drop (eucalyptus oil + menthol)
  40. Beech nut wild cherry cough drops (eucalyptus oil + menthol)
  41. Beech-nut menthol cough drops (anethole + eucalyptus oil + menthol)
  42. Ben-gay arthritis pain rub ont (menthol + methyl salicylate)
  43. Ben-gay ultra strength pain relieving rub (camphor + menthol + methyl salicylate)
  44. Bengay arthritis extra strength (menthol + methyl salicylate)
  45. Bengay muscle pain regular strength (menthol + methyl salicylate)
  46. Bengay muscle pain ultra strength (camphor + menthol + methyl salicylate)
  47. Bentasil cherry (anethole + menthol)
  48. Bentasil extra strength eucalyptus (eucalyptus oil + menthol)
  49. Bentasil extra strength menthol (eucalyptus oil + menthol)
  50. Bentasil green (anethole + eucalyptol + menthol)
  51. Bentasil honey-lemon (anethole + menthol)
  52. Bentasil red (anethole + menthol)
  53. Bentasil yellow (anethole + menthol)
  54. Benylin DM-d-e extra strength with menthactin (dextromethorphan hydrobromide + guaifenesin + menthol + pseudoephedrine hydrochloride)
  55. Benylin DM-e extra strength with menthactin (dextromethorphan hydrobromide + guaifenesin + menthol)
  56. Benylin e extra strength with menthactin (guaifenesin + menthol)
  57. Benylin first defense cough lozenges (echinacea (echinacea angustifolia, echinacea purpurea) + menthol (peppermint oil))
  58. Benylin first defense herbal syrup (echinacea (echinacea angustifolia) + menthol (peppermint oil))
  59. Bigeloil (alcohol anhydrous + menthol + methyl salicylate + salicylic acid + thymol)
  60. Bigeloil liquid gel (alcohol anhydrous + menthol + methyl salicylate + thymol)
  61. Biofreeze (camphor + menthol)
  62. Bite relief (benzocaine + camphor + menthol + phenol)
  63. Braceoil (alcohol anhydrous + camphor + menthol + methyl salicylate + salicylic acid + thymol)
  64. Bronchex cough syrup (ammonia + ammonium carbonate + ammonium chloride + glycerine + glycyrrhiza glabra + menthol + oil of fir + white pine)
  65. Bronchilon cough pastilles (eucalyptus + menthol)
  66. Broncho rub (camphor + menthol + oil of cajeput + turpentine)
  67. Bronchodex vapo ont (camphor + eucalyptus oil + menthol)
  68. Bronchodex-rub (camphor + eucalyptus oil + menthol + methyl salicylate)
  69. Bronchyl SYR (alcohol anhydrous + beechwood creosote + cocillana + eucalyptus + guaiacol oleate + ipecac + lobelia inflata + menthol + myroxylon balsamum + theophylline + white pine)
  70. Buckley's bedtime (diphenhydramine hydrochloride + menthol)
  71. Buckley's complete (acetaminophen + menthol)
  72. Buckley's mixture (ammonium carbonate + camphor + menthol + potassium bicarbonate)
  73. Buckley's pain relief rub (menthol + methyl salicylate)
  74. Buckley's white rub (camphor + menthol + methyl salicylate + thymol)
  75. Cal mo dol ont (camphor + eucalyptol + menthol + methyl salicylate + oil of turpentine + peppermint oil)
  76. Calmitol itching relief ont (camphor + chloral hydrate + hyoscyamine + menthol + zinc oxide)
  77. Campho rex (camphor + menthol)
  78. Camphorated ointment compound (camphor + eucalyptol + menthol)
  79. Camphro septhal ont (camphor + eucalyptus + menthol + methyl salicylate)
  80. Carboseptol (eucalyptol + menthol + methyl salicylate + thymol + zinc oxide)
  81. Chapstick medicated lip balm - STK (camphor + menthol + petrolatum + phenol)
  82. Chapstick medicated lip balm - tube (camphor + menthol + petrolatum + phenol)
  83. Chase coldsorex (benzoin + camphor + menthol + MYRRH)
  84. Chest rub ont (camphor + eucalyptus oil + menthol)
  85. Chloraseptic sore throat lozenges - cherry (benzocaine + menthol)
  86. Chloraseptic sore throat lozenges - menthol (benzocaine + menthol)
  87. Chloraseptic sore throat relief strips (benzocaine + menthol)
  88. Choates veterinary horse liniment (camphor + capsicum + menthol)
  89. Cold sore lotion (benzoin + camphor + menthol)
  90. Cool mint antiseptic mouthwash (eucalyptol + menthol + thymol)
  91. Coolmint antiseptic mouthwash (eucalyptol + menthol + thymol)
  92. Cou formula (belladonna + bryonia + drosera rotundifolia + ipecac + menthol + spongia tosta + sticta pulmonaria + wild thyme)
  93. Cuticura medicated body powder (menthol + zinc oxide)
  94. DR. C's itch not lotion (camphor + menthol)
  95. DR.'s cream (capsaicin + menthol + methyl salicylate)
  96. Deep heating ultra strength rub CRM (menthol + methyl salicylate)
  97. Denorex medicated shampoo - regular (chloroxylenol + coal tar + menthol)
  98. Denorex medicated shampoo spring fresh (chloroxylenol + coal tar + menthol)
  99. Dentalgar liq (benzocaine + camphor + clove oil + guaiacol + menthol)
  100. Dermarest plus - gel (diphenhydramine hydrochloride + menthol)
  101. Dermoplast (benzocaine + menthol)
  102. Dermoplast aerosol spray (benzethonium chloride + benzocaine + menthol + oxyquinoline benzoate)
  103. Eagle brand medicated oil (eucalyptus oil + menthol + methyl salicylate)
  104. Em eukal cough DPS (eucalyptus oil + menthol)
  105. Eucamenth (eucalyptus oil + menthol + oil of camphor)
  106. Expectorine (ammonium chloride + eucalyptus oil + menthol)
  107. Extra strength gold bond (menthol + zinc oxide)
  108. Flex-o-flex (capsaicin + menthol)
  109. Flex-o-flex extra-fort (capsaicin + menthol)
  110. Flex-o-flex kamu (camphor + menthol)
  111. Flexall stick (menthol + menthyl salicylate)
  112. Flexogan arthritis pain (camphor + menthol + methyl salicylate)
  113. Flexogan muscle pain (camphor + menthol)
  114. Flexogan sport (camphor + menthol)
  115. Flexogan sport ultra (camphor + menthol + methyl salicylate)
  116. Formula t.t. cold sore cream (camphor + menthol + phenol)
  117. Formule 12 (eucalyptol + menthol)
  118. Forshner's blue lotion (camphor + eucalyptus oil + menthol + methyl salicylate)
  119. Freeze liq (camphor + ethyl ether + glycerine + isopropyl alcohol + menthol)
  120. Fresh taste antiseptic mouthwash (eucalyptol + menthol + thymol)
  121. Gold bond (menthol + zinc oxide)
  122. Gold bond extra strength medicated body lotion (dimethicone + menthol)
  123. Gold bond medicated body powder (menthol + zinc oxide)
  124. Gold bond medicated cream 28G (menthol + pramoxine hydrochloride)
  125. Gold bond medicated lotion (regular strength) (dimethicone + menthol)
  126. Gouttes dentaires (benzocaine + camphor + clove oil + guaiacol + menthol)
  127. Halls blueberry (eucalyptus oil + menthol)
  128. Halls centres cherry lozenges (eucalyptus oil + menthol)
  129. Halls centres honey lemon (eucalyptus oil + menthol)
  130. Halls centres honey-lemon loz (eucalyptus oil + menthol)
  131. Halls centres regular (eucalyptus oil + menthol)
  132. Halls extra strong (eucalyptus oil + menthol)
  133. Halls extra strong mentho-lyptus cough tab (eucalyptus oil + menthol)
  134. Halls extra strong mentho-lyptus cough tablets (eucalyptus oil + menthol)
  135. Halls lemon-lime (eucalyptus oil + menthol)
  136. Halls mentho lyptus cough tab (eucalyptus oil + menthol)
  137. Halls mentho lyptus cough tab black currant (eucalyptus oil + menthol)
  138. Halls mentho lyptus cough tab cherry (eucalyptus oil + menthol)
  139. Halls mentho lyptus cough tab honey lemon (eucalyptus oil + menthol)
  140. Halls mentho lyptus tab coolmint (eucalyptus oil + menthol)
  141. Halls mentho-lyptus cough tablets black cherry (eucalyptus oil + menthol)
  142. Halls mentho-lyptus cough tablets black currant (eucalyptus oil + menthol)
  143. Halls mentho-lyptus cough tablets cherry (eucalyptus oil + menthol)
  144. Halls mentho-lyptus cough tablets cool mint (eucalyptus oil + menthol)
  145. Halls mentho-lyptus cough tablets honey lemon (eucalyptus oil + menthol)
  146. Halls mentho-lyptus cough tablets mountain menthol (eucalyptus oil + menthol)
  147. Halls mentho-lyptus cough tablets orange (eucalyptus oil + menthol)
  148. Halls mentho-lyptus cough tablets regular (eucalyptus oil + menthol)
  149. Halls mentho-lyptus cough tablets strawberry (eucalyptus oil + menthol)
  150. Heat rub (camphor + eucalyptus oil + menthol + methyl salicylate)
  151. Herbal medicated lozenge (echinacea angustifolia + echinacea purpurea + menthol)
  152. Herbal throat lozenges (camphor + elm bark + horehound + menthol + parsley + thyme)
  153. Herbon cough drops adventurous tingle with a hint of orange flavour (echinacea (echinacea angustifolia, echinacea purpurea) + glycyrrhiza glabra + menthol)
  154. Herbon cough drops glacial mint (chamomile + echinacea (echinacea angustifolia, echinacea purpurea) + eucalyptus oil + fritillaria cirrhosa + horehound + menthol + salvia + thyme)
  155. Herbon lemon honey flavour herbal throat drops (echinacea (echinacea angustifolia, echinacea purpurea) + menthol)
  156. Herbon wild cherry flavour throat drops (echinacea (echinacea angustifolia, echinacea purpurea) + glycyrrhiza glabra + lime tree flower + menthol + sambucus nigra + wild cherry)
  157. Honey lemon menthol eucalyptus cough DPS (eucalyptus oil + menthol)
  158. Infraline liq (eucalyptol + menthol + methyl salicylate)
  159. Inno rheuma massage oil (lavender oil + menthol + rosemary oil)
  160. Instant rub ointment (menthol + methyl salicylate)
  161. Itch nix (camphor + menthol)
  162. Kama sutra pleasure balm (benzocaine + camphor + menthol)
  163. Kiro rub (menthol + methyl salicylate)
  164. Kiro rub ont (camphor + eucalyptus oil + menthol + methyl salicylate)
  165. Kiro-rub (eucalyptol + menthol + methyl salicylate)
  166. Kiroflex (camphor + eucalyptus oil + menthol + thymol)
  167. Kobi - CRM (menthol + methyl salicylate)
  168. Koffex DM-d-e - liq (dextromethorphan hydrobromide + guaifenesin + pseudoephedrine hydrochloride)
  169. Kwan loong oil (eucalyptus oil + menthol + methyl salicylate)
  170. Kwan tak hing plaster - pad-PLS (borneol + menthol)
  171. Lakota topical pain reliever (capsaicin + menthol)
  172. Lakota topical pain reliever - extra strength (capsaicin + menthol)
  173. Lamberts SYR (menthol + pine tar)
  174. Leg paint & sweat (glycerine + iodine + isopropyl alcohol + menthol + phenol + potassium iodide)
  175. Leg solution (iodine + menthol + methyl salicylate + potassium iodide + thymol)
  176. Lin o gel (camphor + clove oil + iodine + isopropyl alcohol + menthol + thymol + turpentine)
  177. Lip conditioner lip balm (camphor + menthol + meradimate + padimate o + phenol)
  178. Lip medex (camphor + menthol + phenol)
  179. Lipsorex (benzethonium chloride + menthol + thymol)
  180. Lipsorex - gel (benzethonium chloride + menthol + thymol)
  181. Lipsorex plus (benzethonium chloride + lidocaine + menthol + thymol)
  182. Lipsorex-gel (benzethonium chloride + menthol + thymol)
  183. Listerine antiseptic mouthwash (eucalyptol + menthol + thymol)
  184. Listerine antiseptic mouthwash with fluoride (eucalyptol + menthol + sodium fluoride + thymol)
  185. Listerine antiseptic tartar control mouthwash (eucalyptol + menthol + thymol + zinc chloride)
  186. Lofthouse origin ext-strong fisherman friend (eucalyptus oil + menthol)
  187. Lotion bleu (camphor + menthol + methyl salicylate)
  188. Lotion pour feux sauvages (benzoin + camphor + menthol + MYRRH)
  189. MÉdi-rub (eucalyptus oil + menthol + methyl salicylate)
  190. Marathon deep heat rub (menthol + methyl salicylate)
  191. Marco rub camphorated ont (camphor + eucalyptol + menthol)
  192. Medi-kool pak (aluminum sulfate + arnica + boric acid + calcium acetate + camphor + menthol + methyl salicylate + tannic acid)
  193. Medi-kool titener (arnica + camphor + menthol + methyl salicylate + tannic acid)
  194. Medicated blistex DCT lip balm (camphor + menthol + meradimate + padimate o + phenol)
  195. Medicated blistex DCT lip balm (camphor + menthol + octinoxate + oxybenzone + phenol)
  196. Medicated body powder (menthol + zinc oxide)
  197. Medicated chest rub (camphor + eucalyptus oil + menthol)
  198. Medicated chest rub - ont (camphor + eucalyptus oil + menthol)
  199. Medicated chest rub - ont top (camphor + eucalyptus oil + menthol)
  200. Medicated ointment (camphor + eucalyptus oil + menthol)
  201. Medicated vapourizer fluid (camphor + eucalyptus oil + menthol)
  202. Medimentol ont (camphor + eucalyptus oil + menthol + oil of camphor + oil of fir + turpentine)
  203. Menthacin - cream (capsaicin + menthol)
  204. Menthacin cream (capsaicin + menthol)
  205. Menthacin lotion (capsaicin + menthol)
  206. Mentholatum cough drops (eucalyptus oil + menthol)
  207. Mentholatum deep heating lot (menthol + methyl salicylate)
  208. Mentholatum deep heating rub (menthol + methyl salicylate)
  209. Mentholatum extra strength ont (camphor + eucalyptus oil + menthol)
  210. Mentholatum ont (camphor + menthol)
  211. Minard's joint relief (menthol + methyl salicylate)
  212. Multi rub (eucalyptol + menthol + methyl salicylate)
  213. Multi-freeze ont (camphor + isopropyl alcohol + menthol)
  214. Muscle liniment (camphor + isopropyl alcohol + menthol + oil of dwarf pine needles)
  215. Muscle mist (clove oil + menthol)
  216. Myoflex extra strength ice (menthol + trolamine salicylate)
  217. Myoflex ice cold plus - gel (menthol + trolamine salicylate)
  218. Myoflex ice plus - CRM (menthol + trolamine salicylate)
  219. Natur 911 (camphor + eucalyptus oil + menthol + phenol + thymol)
  220. Naturland sports cream (camphor + menthol)
  221. Nose head clear (camphor + eucalyptus oil + menthol)
  222. Obus form therapeutic heat rub (menthol + methyl salicylate)
  223. Onguent camphre menthol alsi (camphor + eucalyptol + menthol)
  224. Onguent vaporisant (camphor + eucalyptus oil + menthol)
  225. Orajel denture plus (benzocaine + menthol)
  226. Orajel multi-action cold sore medicine (allantoin + benzocaine + camphor + dimethicone + menthol + white petrolatum)
  227. Orajel ultra canker sore medicine (benzocaine + menthol)
  228. Original antiseptic mouthwash (eucalyptol + menthol + thymol)
  229. Orthorub (eucalyptol + menthol + methyl salicylate)
  230. Pain buster 2000 (camphor + eucalyptus oil + menthol + methyl salicylate)
  231. Pain relieving ointment (camphor + cinnamon oil + clove oil + mentha arvensis + menthol + oil of cajeput)
  232. Pain relieving salonpas patch (camphor + l-menthol + methyl salicylate)
  233. Pain-a-trate cream (camphor + menthol + methyl salicylate)
  234. Pastilles valda (eucalyptol + guaiacol + menthol + terpin hydrate + thymol)
  235. Penetrating rub ont (eucalyptus oil + menthol + methyl salicylate + oil of cajeput + oil of mustard expressed)
  236. Physio-rub (eucalyptol + menthol + methyl salicylate)
  237. Physiorub plus (eucalyptol + menthol + methyl salicylate)
  238. Phytorub ont (eucalyptol + menthol + methyl salicylate)
  239. Polar ice paste (camphor + isopropyl alcohol + menthol)
  240. Pommade au the des bois (camphor + eucalyptol + menthol + methyl salicylate)
  241. Poudre (menthol + zinc oxide)
  242. Pramegel 1% (menthol + pramoxine hydrochloride)
  243. Prosync muscle rub (menthol + methyl salicylate)
  244. Pulmoll menthol - eucalyptol pastilles (eucalyptus oil + menthol + peppermint oil)
  245. Pulmoll pastilles (glycyrrhizin + menthol)
  246. Pulmosirum decongestionnant sirop (beechwood creosote + cocillana + eucalyptus + guaiacol + ipecac + lobelia inflata + menthol + myroxylon balsamum + pseudoephedrine hydrochloride + white pine)
  247. Pulmosirum plus expectorant (ammonium chloride + beechwood creosote + cocillana + eucalyptus oil + guaiacol + guaifenesin + ipecac + lobelia inflata + menthol + myroxylon balsamum + white pine)
  248. R76 (aconite + ammi visnaga + convallaria majalis + drosera rotundifolia + lobelia inflata + menthol + potassium iodide + stramonium)
  249. Rheila medicated cough DPS (glycyrrhiza glabra + menthol)
  250. Rheumalan ont (belladonna + camphor + capsicum oleoresin + croton oil + eucalyptus oil + menthol + methyl salicylate + oil of mustard expressed + salicylic acid)
  251. Rhino-vaccin (camphor + chlorobutanol + eucalyptol + l-ephedrine hydrochloride + menthol)
  252. Rub a 535 ancient secret - natural source (camphor (cinnamomum camphora) + eucalyptus oil (eucalyptus globulus, eucalyptus fructicetorum, eucalyptus smithII) + menthol (peppermint) + methyl salicylate (wintergreen leaf))
  253. Rub a 535 dual action (camphor + eucalyptus oil + menthol + methyl salicylate)
  254. Salonpas - PLS top (camphor + glycol salicylate + l-menthol + methyl salicylate + thymol)
  255. Salonpas gel-patch (camphor + glycol salicylate + l-menthol)
  256. Savex with sunscreen ont (camphor + menthol + salicylic acid)
  257. Scalpicin (menthol + salicylic acid)
  258. Scarlet oil pump spray (eucalyptus oil + menthol + oil of camphor + oil of thyme + peruvian balsam + phenol + pine oil)
  259. Solucodan syrup (hydrocodone bitartrate + menthol + potassium guaiacol sulphonate + sodium citrate)
  260. Solucodan-h (diphenylpyraline hydrochloride + hydrocodone bitartrate + menthol + potassium guaiacol sulphonate + sodium citrate)
  261. Sore throat lozenges menthol flavour (benzocaine + menthol)
  262. Sore throat lozenges with benzocaine and menthol (benzocaine + menthol)
  263. Star-vi-dol (ammonium chloride + eucalyptol + menthol + myroxylon balsamum + white pine + wild cherry)
  264. Strepsils cherry (amylmetacresol + dichlorobenzyl alcohol + menthol)
  265. Sucrets cherry vapour action loz (hexylresorcinol + menthol)
  266. Tensol (iodine + menthol + potassium iodide)
  267. Thera patch (camphor + menthol + methyl salicylate)
  268. Therapatch vapor - chest (camphor + eucalyptus oil + menthol)
  269. Therapatch vapour - nose & chin (camphor + eucalyptus oil + menthol)
  270. Thermo-gel (benzocaine + camphor + menthol + thymol)
  271. Thuna balsam salve ont (eucalyptus oil + menthol + methyl salicylate)
  272. Thunas salve for rheumatic pains (camphor + menthol + methyl salicylate)
  273. Tiger balm arthritis rub (camphor + clove oil + dementholised mint oil + menthol + oil of cajeput)
  274. Tiger balm liniment (eucalyptus oil + menthol + methyl salicylate)
  275. Tiger balm patch warm (camphor + capsaicin + dementholised mint oil + eucalyptus oil + menthol)
  276. Tiger balm red extra strength (camphor + cinnamon oil + clove oil + menthol + oil of cajeput + peppermint oil)
  277. Tiger balm red strong (camphor + cinnamon oil + clove oil + menthol + oil of cajeput + peppermint oil)
  278. Tiger balm ultra (camphor + cinnamon oil + clove oil + menthol + oil of cajeput + peppermint oil)
  279. Tiger balm white extra strength (camphor + clove oil + menthol + oil of cajeput + peppermint oil)
  280. Tiger balm white regular (camphor + clove oil + menthol + oil of cajeput + peppermint oil)
  281. Tobtox (benzene + cactus grandiflorus + coffea tosta + daphne indica + delphinium staphisagria + eucalyptus + lobelia inflata + lycopodium clavatum + menthol + naphthalene + nitric acid + oats + phosphorus + potassium phosphate dibasic + tobacco)
  282. Trialine (menthol + methyl salicylate)
  283. Triaminic vapour patch (camphor + eucalyptus oil + menthol)
  284. Valda pastilles (eucalyptol + guaiacol + menthol + terpin hydrate + thymol)
  285. Valda pastilles lemon flavoured (eucalyptol + guaiacol + menthol + terpin hydrate + thymol)
  286. Vaporisateur medicamente (camphor + eucalyptol + menthol + thymol)
  287. Vaporisateur medicamente aero (camphor + eucalyptus oil + menthol + thymol)
  288. Vaporizing colds rub - ont (camphor + eucalyptus oil + menthol)
  289. Vapourizing colds rub (camphor + eucalyptus oil + menthol)
  290. Vicks inhaler (camphor + menthol)
  291. Vicks vapo steam medication (camphor + eucalyptus oil + lavender oil + menthol + methyl salicylate + peppermint oil)
  292. Vicks vaporub lemon ointment (camphor + eucalyptus oil + menthol)
  293. Vicks vaporub lotion (camphor + eucalyptus oil + menthol)
  294. Vitarub ont (eucalyptol + menthol + methyl salicylate)
  295. Watkins analgesic balm (capsicum oleoresin + menthol + methyl salicylate + oil of turpentine)
  296. Watkins medicated ointment (camphor + menthol)
  297. Watkins medicated ont (camphor + eucalyptus oil + menthol + oil of camphor + phenol)
  298. White flower analgesic balm (camphor + eucalyptus oil + menthol + methyl salicylate + peppermint oil)
  299. Wonder oil (alcohol anhydrous + camphor + clove oil + menthol + oil of sassafras)
  300. Wonder oil (clove oil + menthol)
  301. Wood lock medicated balm (camphor + menthol + methyl salicylate + oil of turpentine)
  302. Wrigley's alpine (eucalyptus oil + menthol)
  303. Wrigley's alpine cherry (eucalyptus oil + menthol)
  304. Youngflex massage ointment 168 (eucalyptus oil + menthol + oil of cajeput)
  305. Zev (ammonium carbonate + buckthorn + camphor + menthol + potassium bicarbonate + squill)
  306. Zilactin-lip (regular and cherry flavour) (dimethicone + homosalate + menthol + octinoxate + oxybenzone)
Chemical IUPAC Name (1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol
Chemical Formula C10H20O
Chemical Structure Structure
CAS Registry Number 2216-51-5
InChI Identifier InChI=1/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
InChI Key NOOLISFMXDJSKH-KXUCPTDWBX
KEGG Drug D00064 Link Image
KEGG Compound C00400 Link Image
PubChem Compound 16666 Link Image
PubChem Substance 3690 Link Image
ChEBI ID 15409 Link Image
PharmGKB ID PA450365 Link Image
HET ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 02241935 Link Image
RxList Link Not Available
PDRhealth Link Not Available
Wikipedia Link http://en.wikipedia.org/wiki/Menthol Link Image
FDA Label Not Available
Material Safety Data Sheet (MSDS)
Synthesis Reference Not Available
Average Molecular Weight 156.2652
Monoisotopic Molecular Weight 156.1514
State Solid
Melting Point 43 oC
Experimental Water Solubility 0.49 mg/mL at 25 oC [CHEM INSPECT TEST INST (1992)] Source: PhysProp
Predicted Water Solubility 5.58e-01 mg/mL Calculated using ALOGPS
Experimental LogP/Hydrophobicity 3.2 Source: PhysProp
Predicted LogP 2.68 Calculated using ALOGPS
Experimental LogS Not Available
Predicted LogS -2.45 Calculated using ALOGPS
Experimental Caco2 Permeability Not Available
pKa/Isoelectric Point Not Available
Mass Spectrum Not Available
MOL File Show Link Image | Download Link Image
SDF File Show Link Image | Download Link Image
PDB File Show Link Image | Download Link Image
2D Structure
3D Structure
Experimental PDB ID Not Available
Isomeric SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Canonical SMILES CC(C)C1CCC(C)CC1O
Drug Category
  • Antipruritics
ATC Codes
AHFS Codes
  • 48:01.00*
  • 52:92.00
  • 84:08.00
  • 84:08.01*
  • 84:24.04
  • 92:02.00*
Indication Used to treat occasional minor irritation, pain, sore mouth, and sore throat as well as cough associated with a cold or inhaled irritants.
Pharmacology Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Menthol's ability to chemically trigger cold-sensitive receptors in the skin is responsible for the well known cooling sensation that it provokes when inhalated, eaten, or applied to the skin. It should be noted that menthol does not cause an actual drop in temperature.
Mechanism of Action Menthol is classified as a calcium channel blocker. Calcium channel blockers are a class of drugs with effects on many excitable cells of the body, like the muscle of the heart, smooth muscles of the vessels or neuron cells. Calcium channel blockers work by blocking voltage-sensitive calcium channels in the heart and in the blood vessels. This prevents calcium levels from increasing as much in the cells when stimulated, leading to less contraction.
Absorption Not Available
Toxicity Menthol, DL: ORAL (LD50): Acute: 2900 mg/kg [Rat], 3100 mg/kg [Mouse]. DERMAL (LD50): Acute: 5001 mg/kg [Rabbit].
Protein Binding Not Available
Biotransformation Not Available
Half Life Not Available
Dosage Forms
Form Route
Cream Topical
Gel Topical
Liquid Nasal
Liquid Oral
Liquid Topical
Lozenge Oral
Ointment Topical
Patch Topical
Powder Topical
Solution / drops Oral
Spray Topical
Patient Information Not Available
Contraindications Not Available
Interactions Not Available
Drug Interactions Not Available
Food Interactions Not Available
Pathways Not Available
General References
  1. Drugs.com Link Image
  2. Wikipedia Link Image
Organisms Affected
  • Humans and other mammals
Targets
  1. Transient receptor potential cation channel subfamily A member 1
  2. Transient receptor potential cation channel subfamily M member 8
  3. Transient receptor potential cation channel subfamily V member 3
Drug Target 1 [top]
Target 1 ID 1944
Target 1 Name Transient receptor potential cation channel subfamily A member 1
Target 1 Synonyms
  1. Ankyrin-like with transmembrane domains protein 1
  2. Transformation sensitive-protein p120
Target 1 Gene Name TRPA1
Target 1 Protein Sequence >Transient receptor potential cation channel subfamily A member 1 
MKCSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKTCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLNKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
Target 1 Number of Residues 1137
Target 1 Molecular Weight 127381
Target 1 Theoretical pI 6.98
Target 1 GO Classification
Function
transporter activity
ion transporter activity
ion channel activity
Process
physiological process
cellular physiological process
transport
ion transport
Component
cell
membrane
Target 1 General Function Involved in ion channel activity
Target 1 Specific Function Receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Also involved in pain sensation triggered by capsaicin, the pungent ingredient in chilli peppers. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system
Target 1 Pathways Not Available
Target 1 Reactions Not Available
Target 1 Pfam Domain Function
Target 1 Signals
  • None
Target 1 Transmembrane Regions
  • 720-740
  • 773-793
  • 806-826
  • 830-850
  • 874-894
  • 941-961
Target 1 Essentiality Non-Essential
Target 1 GenBank ID Protein 3287188 Link Image
Target 1 UniProtKB/Swiss-Prot ID O75762 Link Image
Target 1 UniProtKB/Swiss-Prot Entry Name TRPA1_HUMAN Link Image
Target 1 PDB ID Not Available
Target 1 Cellular Location
  • Membrane
  • multi-pass membrane protein (Probable)
Target 1 Gene Sequence >3360 bp 
ATGAAGTGCAGCCTGAGGAAGATGTGGCGCCCTGGAGAAAAGAAGGAGCCCCAGGGCGTT
GTCTATGAGGATGTGCCGGACGACACGGAGGATTTCAAGGAATCGCTTAAGGTGGTTTTT
GAAGGAAGTGCATATGGATTACAAAACTTTAATAAGCAAAAGAAATTAAAAACATGTGAC
GATATGGACACCTTCTTCTTGCATTATGCTGCAGCAGAAGGCCAAATTGAGCTAATGGAG
AAGATCACCAGAGATTCCTCTTTGGAAGTGCTGCATGAAATGGATGATTATGGAAATACC
CCTCTGCATTGTGCTGTAGAAAAAAACCAAATTGAAAGCGTTAAGTTTCTTCTCAGCAGA
GGAGCAAACCCAAACCTCCGAAACTTCAACATGATGGCTCCTCTCCACATAGCTGTGCAG
GGCATGAATAATGAGGTGATGAAGGTCTTGCTTGAGCATAGAACTATTGATGTTAATTTG
GAAGGAGAAAATGGAAACACAGCTGTGATCATTGCGTGCACCACAAATAATAGCGAAGCA
TTGCAGATTTTGCTTAACAAAGGAGCTAAGCCATGTAAATCAAATAAATGGGGATGTTTC
CCTATTCACCAAGCTGCATTTTCAGGTTCCAAAGAATGCATGGAAATAATACTAAGGTTT
GGTGAAGAGCATGGGTACAGTAGACAGTTGCACATTAACTTTATGAATAATGGGAAAGCC
ACCCCTCTCCACCTGGCTGTGCAAAATGGTGACTTGGAAATGATCAAAATGTGCCTGGAC
AATGGTGCACAAATAGACCCAGTGGAGAAGGGAAGGTGCACAGCCATTCATTTTGCTGCC
ACCCAGGGAGCCACTGAGATTGTTAAACTGATGATATCGTCCTATTCTGGTAGCGTGGAT
ATTGTTAACACAACCGATGGATGTCATGAGACCATGCTTCACAGAGCTTCATTGTTTGAT
CACCATGAGCTAGCAGACTATTTAATTTCAGTGGGAGCAGATATTAATAAGATCGATTCT
GAAGGACGCTCTCCACTTATATTAGCAACTGCTTCTGCATCTTGGAATATTGTAAATTTG
CTACTCTCTAAAGGTGCCCAAGTAGACATAAAAGATAATTTTGGACGTAATTTTCTGCAT
TTAACTGTACAGCAACCTTATGGATTAAAAAATCTGCGACCTGAATTTATGCAGATGCAA
CAGATCAAAGAGCTGGTAATGGATGAAGACAACGATGGGTGTACTCCTCTACATTATGCA
TGTAGACAGGGGGGCCCTGGTTCTGTAAATAACCTACTTGGCTTTAATGTGTCCATTCAT
TCCAAAAGCAAAGATAAGAAATCACCTCTGCATTTTGCAGCCAGTTATGGGCGTATCAAT
ACCTGTCAGAGGCTCCTACAAGACATAAGTGATACGAGGCTTCTGAATGAAGGTGACCTT
CATGGAATGACTCCTCTCCATCTGGCAGCAAAGAATGGACATGATAAAGTAGTTCAGCTT
CTTCTGAAAAAAGGTGCATTGTTTCTCAGTGACCACAATGGCTGGACAGCTTTGCATCAT
GCGTCCATGGGCGGGTACACTCAGACCATGAAGGTCATTCTTGATACTAATTTGAAGTGC
ACAGATCGCTTGGATGAAGACGGGAACACTGCACTTCACTTTGCTGCAAGGGAAGGCCAC
GCCAAAGCCGTTGCGCTTCTTCTGAGCCACAATGCTGACATAGTCCTGAACAAGCAGCAG
GCCTCCTTTTTGCACCTTGCACTTCACAATAAGAGGAAGGAGGTTGTTCTTACGATCATC
AGGAGCAAAAGATGGGATGAATGTCTTAAGATTTTCAGTCATAATTCTCCAGGCAATAAA
TGTCCAATTACAGAAATGATAGAATACCTCCCTGAATGCATGAAGGTACTTTTAGATTTC
TGCATGTTGCATTCCACAGAAGACAAGTCCTGCCGAGACTATTATATCGAGTATAATTTC
AAATATCTTCAATGTCCATTAGAATTCACCAAAAAAACACCTACACAGGATGTTATATAT
GAACCGCTTACAGCCCTCAACGCAATGGTACAAAATAACCGCATAGAGCTTCTCAATCAT
CCTGTGTGTAAAGAATATTTACTCATGAAATGGTTGGCTTATGGATTTAGAGCTCATATG
ATGAATTTAGGATCTTACTGTCTTGGTCTCATACCTATGACCATTCTCGTTGTCAATATA
AAACCAGGAATGGCTTTCAACTCAACTGGCATCATCAATGAAACTAGTGATCATTCAGAA
ATACTAGATACCACGAATTCATATCTAATAAAAACTTGTATGATTTTAGTGTTTTTATCA
AGTATATTTGGGTATTGCAAAGAAGCGGGGCAAATTTTCCAACAGAAAAGGAATTATTTT
ATGGATATAAGCAATGTTCTTGAATGGATTATCTACACGACGGGCATCATTTTTGTGCTG
CCCTTGTTTGTTGAAATACCAGCTCATCTGCAGTGGCAATGTGGAGCAATTGCTGTTTAC
TTCTATTGGATGAATTTCTTATTGTATCTTCAAAGATTTGAAAATTGTGGAATTTTTATT
GTTATGTTGGAGGTAATTTTGAAAACTTTGTTGAGGTCTACAGTTGTATTTATCTTCCTT
CTTCTGGCTTTTGGACTCAGCTTTTACATCCTCCTGAATTTACAGGATCCCTTCAGCTCT
CCATTGCTTTCTATAATCCAGACCTTCAGCATGATGCTAGGAGATATCAATTATCGAGAG
TCCTTCCTAGAACCATATCTGAGAAATGAATTGGCACATCCAGTTCTGTCCTTTGCACAA
CTTGTTTCCTTCACAATATTTGTCCCAATTGTCCTCATGAATTTACTTATTGGTTTGGCA
GTTGGCGACATTGCTGAGGTCCAGAAACATGCATCATTGAAGAGGATAGCTATGCAGGTG
GAACTTCATACCAGCTTAGAGAAGAAGCTGCCACTTTGGTTTCTACGCAAAGTGGATCAG
AAATCCACCATCGTGTATCCCAACAAACCCAGATCTGGTGGGATGTTATTCCATATATTC
TGTTTTTTATTTTGCACTGGGGAAATAAGACAAGAAATACCAAATGCTGATAAATCTTTA
GAAATGGAAATATTAAAGCAGAAATACCGGCTGAAGGATCTTACTTTTCTCCTGGAAAAA
CAGCATGAGCTCATTAAACTGATCATTCAGAAGATGGAGATCATCTCTGAGACAGAGGAT
GATGATAGCCATTGTTCTTTTCAAGACAGGTTTAAGAAAGAGCAGATGGAACAAAGGAAT
AGCAGATGGAATACTGTGTTGAGAGCAGTCAAGGCAAAAACACACCATCTTGAGCCTTAG
Target 1 GenBank Gene ID
Target 1 GeneCard ID TRPA1 Link Image
Target 1 GenAtlas ID TRPA1 Link Image
Target 1 HGNC ID HGNC:497 Link Image
Target 1 Chromosome Location 8
Target 1 Locus 8q13
Target 1 SNPs SNPJam Report Link Image
Target 1 General References
  1. Jaquemar D, Schenker T, Trueb B: An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J Biol Chem. 1999 Mar 12;274(11):7325-33. [PubMed Link Image]
Target 1 Drug References
  1. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A: ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29. [PubMed Link Image]
  2. Namer B, Seifert F, Handwerker HO, Maihofner C: TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. Neuroreport. 2005 Jun 21;16(9):955-9. [PubMed Link Image]
  3. Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM: More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci. 2006 Aug;32(4):335-43. Epub 2006 Jul 7. [PubMed Link Image]
Drug Target 2 [top]
Target 2 ID 2162
Target 2 Name Transient receptor potential cation channel subfamily M member 8
Target 2 Synonyms
  1. LTrpC6
  2. Long transient receptor potential channel 6
  3. Transient receptor potential-p8
  4. Trp-p8
Target 2 Gene Name TRPM8
Target 2 Protein Sequence >Transient receptor potential cation channel subfamily M member 8 
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQY
LMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE
QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC
DEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY
FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH
RFRQLDTKLNDLKGLLKEIANKIK
Target 2 Number of Residues 1122
Target 2 Molecular Weight 127686
Target 2 Theoretical pI 7.25
Target 2 GO Classification Not Available
Target 2 General Function Not Available
Target 2 Specific Function Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Pfam Domain Function Not Available
Target 2 Signals
  • None
Target 2 Transmembrane Regions
  • 692-712
  • 735-755
  • 760-780
  • 795-815
  • 830-850
  • 959-979
Target 2 Essentiality Non-Essential
Target 2 GenBank ID Protein 20147036 Link Image
Target 2 UniProtKB/Swiss-Prot ID Q7Z2W7 Link Image
Target 2 UniProtKB/Swiss-Prot Entry Name TRPM8_HUMAN Link Image
Target 2 PDB ID Not Available
Target 2 Cellular Location
  • Membrane
  • multi-pass membrane protein (Probable)
Target 2 Gene Sequence >3315 bp 
ATGTCCTTTCGGGCAGCCAGGCTCAGCATGAGGAACAGAAGGAATGACACTCTGGACAGC
ACCCGGACCCTGTACTCCAGCGCGTCTCGGAGCACAGACTTGTCTTACAGTGAAAGCGAC
TTGGTGAATTTTATTCAAGCAAATTTTAAGAAACGAGAATGTGTCTTCTTTATCAAAGAT
TCCAAGGCCACGGAGAATGTGTGCAAGTGTGGCTATGCCCAGAGCCAGCACATGGAAGGC
ACCCAGATCAACCAAAGTGAGAAATGGAACTACAAGAAACACACCAAGGAATTTCCTACC
GACGCCTTTGGGGATATTCAGTTTGAGACACTGGGGAAGAAAGGGAAGTATATACGTCTG
TCCTGCGACACGGACGCGGAAATCCTTTACGAGCTGCTGACCCAGCACTGGCACCTGAAA
ACACCCAACCTGGTCATTTCTGTGACCGGGGGCGCCAAGAACTTCGCCCTGAAGCCGCGC
ATGCGCAAGATCTTCAGCCGGCTCATCTACATCGCGCAGTCCAAAGGTGCTTGGATTCTC
ACGGGAGGCACCCATTATGGCCTGATGAAGTACATCGGGGAGGTGGTGAGAGATAACACC
ATCAGCAGGAGTTCAGAGGAGAATATTGTGGCCATTGGCATAGCAGCTTGGGGCATGGTC
TCCAACCGGGACACCCTCATCAGGAATTGCGATGCTGAGGGCTATTTTTTAGCCCAGTAC
CTTATGGATGACTTCACAAGAGATCCACTGTATATCCTGGACAACAACCACACACATTTG
CTGCTCGTGGACAATGGCTGTCATGGACATCCCACTGTCGAAGCAAAGCTCCGGAATCAG
CTAGAGAAGTATATCTCTGAGCGCACTATTCAAGATTCCAACTATGGTGGCAAGATCCCC
ATTGTGTGTTTTGCCCAAGGAGGTGGAAAAGAGACTTTGAAAGCCATCAATACCTCCATC
AAAAATAAAATTCCTTGTGTGGTGGTGGAAGGCTCGGGCCAGATCGCTGATGTGATCGCT
AGCCTGGTGGAGGTGGAGGATGCCCTGACATCTTCTGCCGTCAAGGAGAAGCTGGTGCGC
TTTTTACCCCGCACGGTGTCCCGGCTGCCTGAGGAGGAGACTGAGAGTTGGATCAAATGG
CTCAAAGAAATTCTCGAATGTTCTCACCTATTAACAGTTATTAAAATGGAAGAAGCTGGG
GATGAAATTGTGAGCAATGCCATCTCCTACGCTCTATACAAAGCCTTCAGCACCAGTGAG
CAAGACAAGGATAACTGGAATGGGCAGCTGAAGCTTCTGCTGGAGTGGAACCAGCTGGAC
TTAGCCAATGATGAGATTTTCACCAATGACCGCCGATGGGAGTCTGCTGACCTTCAAGAA
GTCATGTTTACGGCTCTCATAAAGGACAGACCCAAGTTTGTCCGCCTCTTTCTGGAGAAT
GGCTTGAACCTACGGAAGTTTCTCACCCATGATGTCCTCACTGAACTCTTCTCCAACCAC
TTCAGCACGCTTGTGTACCGGAATCTGCAGATCGCCAAGAATTCCTATAATGATGCCCTC
CTCACGTTTGTCTGGAAACTGGTTGCGAACTTCCGAAGAGGCTTCCGGAAGGAAGACAGA
AATGGCCGGGACGAGATGGACATAGAACTCCACGACGTGTCTCCTATTACTCGGCACCCC
CTGCAAGCTCTCTTCATCTGGGCCATTCTTCAGAATAAGAAGGAACTCTCCAAAGTCATT
TGGGAGCAGACCAGGGGCTGCACTCTGGCAGCCCTGGGAGCCAGCAAGCTTCTGAAGACT
CTGGCCAAAGTGAAGAACGACATCAATGCTGCTGGGGAGTCCGAGGAGCTGGCTAATGAG
TACGAGACCCGGGCTGTTGAGCTGTTCACTGAGTGTTACAGCAGCGATGAAGACTTGGCA
GAACAGCTGCTGGTCTATTCCTGTGAAGCTTGGGGTGGAAGCAACTGTCTGGAGCTGGCG
GTGGAGGCCACAGACCAGCATTTCATCGCCCAGCCTGGGGTCCAGAATTTTCTTTCTAAG
CAATGGTATGGAGAGATTTCCCGAGACACCAAGAACTGGAAGATTATCCTGTGTCTGTTT
ATTATACCCTTGGTGGGCTGTGGCTTTGTATCATTTAGGAAGAAACCTGTCGACAAGCAC
AAGAAGCTGCTTTGGTACTATGTGGCGTTCTTCACCTCCCCCTTCGTGGTCTTCTCCTGG
AATGTGGTCTTCTACATCGCCTTCCTCCTGCTGTTTGCCTACGTGCTGCTCATGGATTTC
CATTCGGTGCCACACCCCCCCGAGCTGGTCCTGTACTCGCTGGTCTTTGTCCTCTTCTGT
GATGAAGTGAGACAGTGGTACGTAAATGGGGTGAATTATTTTACTGACCTGTGGAATGTG
ATGGACACGCTGGGGCTTTTTTACTTCATAGCAGGAATTGTATTTCGGCTCCACTCTTCT
AATAAAAGCTCTTTGTATTCTGGACGAGTCATTTTCTGTCTGGACTACATTATTTTCACT
CTAAGATTGATCCACATTTTTACTGTAAGCAGAAACTTAGGACCCAAGATTATAATGCTG
CAGAGGATGCTGATCGATGTGTTCTTCTTCCTGTTCCTCTTTGCGGTGTGGATGGTGGCC
TTTGGCGTGGCCAGGCAAGGGATCCTTAGGCAGAATGAGCAGCGCTGGAGGTGGATATTC
CGTTCGGTCATCTACGAGCCCTACCTGGCCATGTTCGGCCAGGTGCCCAGTGACGTGGAT
GGTACCACGTATGACTTTGCCCACTGCACCTTCACTGGGAATGAGTCCAAGCCACTGTGT
GTGGAGCTGGATGAGCACAACCTGCCCCGGTTCCCCGAGTGGATCACCATCCCCCTGGTG
TGCATCTACATGTTATCCACCAACATCCTGCTGGTCAACCTGCTGGTCGCCATGTTTGGC
TACACGGTGGGCACCGTCCAGGAGAACAATGACCAGGTCTGGAAGTTCCAGAGGTACTTC
CTGGTGCAGGAGTACTGCAGCCGCCTCAATATCCCCTTCCCCTTCATCGTCTTCGCTTAC
TTCTACATGGTGGTGAAGAAGTGCTTCAAGTGTTGCTGCAAGGAGAAAAACATGGAGTCT
TCTGTCTGCTGTTTCAAAAATGAAGACAATGAGACTCTGGCATGGGAGGGTGTCATGAAG
GAAAACTACCTTGTCAAGATCAACACAAAAGCCAACGACACCTCAGAGGAAATGAGGCAT
CGATTTAGACAACTGGATACAAAGCTTAATGATCTCAAGGGTCTTCTGAAAGAGATTGCT
AATAAAATCAAATAA
Target 2 GenBank Gene ID
Target 2 GeneCard ID TRPM8 Link Image
Target 2 GenAtlas ID TRPM8 Link Image
Target 2 HGNC ID HGNC:17961 Link Image
Target 2 Chromosome Location 2
Target 2 Locus 2q37.1
Target 2 SNPs SNPJam Report Link Image
Target 2 General References
  1. Tsavaler L, Shapero MH, Morkowski S, Laus R: Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res. 2001 May 1;61(9):3760-9. [PubMed Link Image]
Target 2 Drug References
  1. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A: ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29. [PubMed Link Image]
  2. Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R: Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. Epub 2004 Feb 2. [PubMed Link Image]
  3. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A: Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004 Mar 25;41(6):849-57. [PubMed Link Image]
  4. Andersson DA, Chase HW, Bevan S: TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci. 2004 Jun 9;24(23):5364-9. [PubMed Link Image]
  5. Stein RJ, Santos S, Nagatomi J, Hayashi Y, Minnery BS, Xavier M, Patel AS, Nelson JB, Futrell WJ, Yoshimura N, Chancellor MB, De Miguel F: Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. J Urol. 2004 Sep;172(3):1175-8. [PubMed Link Image]
Drug Target 3 [top]
Target 3 ID 5838
Target 3 Name Transient receptor potential cation channel subfamily V member 3
Target 3 Synonyms
  1. TrpV3
  2. VRL-3
  3. Vanilloid receptor-like 3
Target 3 Gene Name TRPV3
Target 3 Protein Sequence >Transient receptor potential cation channel subfamily V member 3 
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS
PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK
KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN
PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD
VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL
HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI
LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML
TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG
WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY
LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG
FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT
YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE
EVEEFPETSV
Target 3 Number of Residues 803
Target 3 Molecular Weight 90637
Target 3 Theoretical pI 6.56
Target 3 GO Classification
Function
transporter activity
ion transporter activity
ion channel activity
Process
physiological process
cellular physiological process
transport
ion transport
Component
cell
membrane
Target 3 General Function Involved in ion channel activity
Target 3 Specific Function Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity
Target 3 Pathways Not Available
Target 3 Reactions Not Available
Target 3 Pfam Domain Function
Target 3 Signals
  • None
Target 3 Transmembrane Regions
  • 440-460
  • 488-508
  • 524-544
  • 546-566
  • 590-610
  • 650-670
Target 3 Essentiality Non Essential
Target 3 GenBank ID Protein Not Available
Target 3 UniProtKB/Swiss-Prot ID Q8NET8 Link Image
Target 3 UniProtKB/Swiss-Prot Entry Name TRPV3_HUMAN Link Image
Target 3 PDB ID Not Available
Target 3 Cellular Location
  • Membrane
Target 3 Gene Sequence >2373 bp 
ATGAAAGCCCACCCCAAGGAGATGGTGCCTCTCATGGGCAAGAGAGTTGCTGCCCCCAGT
GGGAACCCTGCCGTCCTGCCAGAGAAGAGGCCGGCGGAGATCACCCCCACAAAGAAGAGT
GCACACTTCTTCCTGGAGATAGAAGGGTTTGAACCCAACCCCACAGTTGCCAAGACCTCT
CCTCCTGTCTTCTCCAAGCCCATGGATTCCAACATCCGGCAGTGCATCTCTGGTAACTGT
GATGACATGGACTCCCCCCAGTCTCCTCAGGATGATGTGACAGAGACCCCATCCAATCCC
AACAGCCCCAGTGCACAGCTGGCCAAGGAAGAGCAGAGGAGGAAAAAGGGGCGGCTGAAG
AAGCGCATCTTTGCAGCCGTGTCTGAGGGCTGCGTGGAGGAGTTGGTAGAGTTGCTGGTG
GAGCTGCAGGAGCTTTGCAGGCGGCGCCATGATGAGGATGTGCCTGACTTCCTCATGCAC
AAGCTGACGGCCTCCGACACGGGGAAGACCTGCCTGATGAAGGCCTTGTTAAACATCAAC
CCCAACACCAAGGAGATAGTGCGGATCCTGCTTGCCTTTGCTGAAGAGAACGACATCCTG
GGCAGGTTCATCAACGCCGAGTACACAGAGGAGGCCTATGAAGGGCAGACGGCGCTGAAC
ATCGCCATCGAGCGGCGGCAGGGGGACATCGCAGCCCTGCTCATCGCCGCCGGCGCCGAC
GTCAACGCGCACGCCAAGGGGGCCTTCTTCAACCCCAAGTACCAACACGAAGGCTTCTAC
TTCGGTGAGACGCCCCTGGCCCTGGCAGCATGCACCAACCAGCCCGAGATTGTGCAGCTG
CTGATGGAGCACGAGCAGACGGACATCACCTCGCGGGACTCACGAGGCAACAACATCCTT
CACGCCCTGGTGACCGTGGCCGAGGACTTCAAGACACAGAATGACTTTGTGAAGCGCATG
TACGACATGATCCTACTGCGGAGTGGCAACTGGGAGCTGGAGACCACTCGCAACAACGAT
GGCCTCACGCCGCTGCAGCTGGCCGCCAAGATGGGCAAGGCGGAGATCCTGAAGTACATC
CTCAGTCGTGAGATCAAGGAGAAGCGGCTCCGGAGCCTGTCCAGGAAGTTCACCGACTGG
GCGTACGGACCCGTGTCATCCTCCCTCTACGACCTCACCAACGTGGACACCACCACGGAC
AACTCAGTGCTGGAAATCACTGTCTACAACACCAACATCGACAACCGGCATGAGATGCTG
ACCCTGGAGCCGCTGCACACGCTGCTGCATATGAAGTGGAAGAAGTTTGCCAAGCACATG
TTCTTTCTGTCCTTCTGCTTTTATTTCTTCTACAACATCACCCTGACCCTCGTCTCGTAC
TACCGCCCCCGGGAGGAGGAGGCCATCCCGCACCCCTTGGCCCTGACGCACAAGATGGGG
TGGCTGCAGCTCCTAGGGAGGATGTTTGTGCTCATCTGGGCCATGTGCATCTCTGTGAAA
GAGGGCATTGCCATCTTCCTGCTGAGACCCTCGGATCTGCAGTCCATCCTCTCGGATGCC
TGGTTCCACTTTGTCTTTTTTATCCAAGCTGTGCTTGTGATACTGTCTGTCTTCTTGTAC
TTGTTTGCCTACAAAGAGTACCTCGCCTGCCTCGTGCTGGCCATGGCCCTGGGCTGGGCG
AACATGCTCTACTATACGCGGGGTTTCCAGTCCATGGGCATGTACAGCGTCATGATCCAG
AAGGTTATTTTGCATGATGTTCTGAAGTTCTTGTTTGTATATATCGTGTTTTTGCTTGGA
TTTGGAGTAGCCTTGGCCTCGCTGATCGAGAAGTGTCCCAAAGACAACAAGGACTGCAGC
TCCTACGGCAGCTTCAGCGACGCAGTGCTGGAACTCTTCAAGCTCACCATAGGCCTGGGT
GATCTGAACATCCAGCAGAACTCCAAGTATCCCATTCTCTTTCTGTTCCTGCTCATCACC
TATGTCATCCTCACCTTTGTTCTCCTCCTCAACATGCTCATTGCTCTGATGGGCGAGACT
GTGGAGAACGTCTCCAAGGAGAGCGAACGCATCTGGCGCCTGCAGAGAGCCAGGACCATC
TTGGAGTTTGAGAAAATGTTACCAGAATGGCTGAGGAGCAGATTCCGGATGGGAGAGCTG
TGCAAAGTGGCCGAGGATGATTTCCGACTGTGTTTGCGGATCAATGAGGTGAAGTGGACT
GAATGGAAGACGCACGTCTCCTTCCTTAACGAAGACCCGGGGCCTGTAAGACGAACAGAT
TTCAACAAAATCCAAGATTCTTCCAGGAACAACAGCAAAACCACTCTCAATGCATTTGAA
GAAGTCGAGGAATTCCCGGAAACCTCGGTGTAG
Target 3 GenBank Gene ID
Target 3 GeneCard ID Not Available
Target 3 GenAtlas ID TRPV3 Link Image
Target 3 HGNC ID HGNC:18084 Link Image
Target 3 Chromosome Location 17
Target 3 Locus 17p13.3
Target 3 SNPs SNPJam Report Link Image
Target 3 General References
  1. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE: TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 2002 Jul 11;418(6894):181-6. Epub 2002 Jun 23. [PubMed Link Image]
  2. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB: TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature. 2002 Jul 11;418(6894):186-90. Epub 2002 Jun 23. [PubMed Link Image]
Target 3 Drug References
  1. Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM: More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci. 2006 Aug;32(4):335-43. Epub 2006 Jul 7. [PubMed Link Image]

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.