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Identification
NameRanitidine
Accession NumberDB00863  (APRD00254)
TypeSmall Molecule
GroupsApproved
Description

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
RANNot AvailableNot Available
RanitidinaNot AvailableNot Available
RanitidinumNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Zantactablet, film coated150 mgoralGlaxo Smith Kline Llc1989-10-01Not AvailableUs
Zantactablet, film coated300 mgoralGlaxo Smith Kline Llc1989-10-01Not AvailableUs
Zantacinjection, solution25 mg/mLintramuscular; intravenousCovis Pharmaceuticals, Inc.2013-03-15Not AvailableUs
Zantacinjection, solution25 mg/mLintramuscular; intravenousCovis Pharmaceuticals, Inc.2013-06-14Not AvailableUs
Zantacinjection, solution25 mg/mLintramuscular; intravenousCovis Pharmaceuticals, Inc.2013-06-14Not AvailableUs
Zantacinjection, solution25 mg/mLintramuscular; intravenousCardinal Health1989-10-01Not AvailableUs
Zantactablet150 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada
Zantactablet300 mgoralGlaxosmithkline IncNot AvailableNot AvailableCanada
Zantacsolution25 mgintramuscularGlaxosmithkline IncNot AvailableNot AvailableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ranitidinesolution15 mg/mLoralPharmaceutical Associates, Inc.2009-09-19Not AvailableUs
Ranitidinesolution15 mg/mLoralPharmaceutical Associates, Inc.2009-09-19Not AvailableUs
Ranitidinetablet, film coated150 mgoralIVAX Pharmaceuticals, Inc.1997-09-12Not AvailableUs
Ranitidinetablet, film coated300 mgoralIVAX Pharmaceuticals, Inc.1998-04-01Not AvailableUs
Ranitidinetablet150 mgoralLiberty Pharmaceuticals, Inc.2009-12-16Not AvailableUs
Ranitidinesolution15 mg/mLoralActavis Mid Atlantic LLC2007-03-15Not AvailableUs
Ranitidinesolution75 mg/5mLoralQualitest Pharmaceuticals2010-07-01Not AvailableUs
Ranitidine Hydrochloridecapsule150 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1997-10-22Not AvailableUs
Ranitidinetablet, film coated150 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-11-06Not AvailableUs
Ranitidinetablet, film coated300 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-11-06Not AvailableUs
Ranitidine Hydrochloridetablet, film coated150 mgoralSandoz Inc1997-08-29Not AvailableUs
Ranitidine Hydrochloridetablet, film coated300 mgoralSandoz Inc1997-08-29Not AvailableUs
Ranitidine Hydrochloridecapsule150 mgoralSandoz Inc1997-10-22Not AvailableUs
Ranitidine Hydrochloridecapsule300 mgoralSandoz Inc1997-10-22Not AvailableUs
Ranitidinesyrup15 mg/mLtopicalSandoz Inc.2011-10-252020-10-25Us
Ranitidinetablet150 mgoralMajor Pharmaceuticals2010-07-23Not AvailableUs
Ranitidinetablet300 mgoralMajor Pharmaceuticals2010-07-23Not AvailableUs
Ranitidinetablet150 mgoralSTAT Rx USA LLC2009-12-16Not AvailableUs
Ranitidinetablet300 mgoralSTAT Rx USA LLC2009-12-16Not AvailableUs
Ranitidinesolution15 mg/mLoralAtlantic Biologicals Corps2010-03-12Not AvailableUs
Ranitidinetablet150 mgoralRebel Distributors2009-12-17Not AvailableUs
Ranitidinetablet300 mgoralRebel Distributors2009-12-17Not AvailableUs
Ranitidine Hydrochloridecapsule150 mgoralRebel Distributors Corp1997-10-22Not AvailableUs
Ranitidine Hydrochloridecapsule300 mgoralRebel Distributors Corp1997-10-22Not AvailableUs
Ranitidinesyrup15 mg/mLoralHeritage Pharmaceuticals Inc.2013-07-15Not AvailableUs
Ranitidinetablet150 mgoralAidarex Pharmaceuticals LLC2009-12-16Not AvailableUs
Ranitidinetablet300 mgoralAidarex Pharmaceuticals LLC2009-12-16Not AvailableUs
Ranitidinetablet150 mgoralRx Change Co.2014-11-25Not AvailableUs
Ranitidinetablet150 mgoralLake Erie Medical DBA Quality Care Products LLC2009-12-16Not AvailableUs
Ranitidinetablet300 mgoralLake Erie Medical DBA Quality Care Products LLC2009-12-16Not AvailableUs
Ranitidinetablet150 mgoralAv Kare, Inc.2014-08-18Not AvailableUs
Ranitidinetablet300 mgoralAv Kare, Inc.2014-08-18Not AvailableUs
Ranitidinetablet300 mgoralSTAT Rx USA LLC1998-12-17Not AvailableUs
Ranitidinetablet300 mgoralPd Rx Pharmaceuticals, Inc.2009-12-16Not AvailableUs
Ranitidine Hydrochloridetablet300 mgoralREMEDYREPACK INC.2013-07-31Not AvailableUs
Ranitidine Hydrochloridetablet300 mgoralREMEDYREPACK INC.2013-12-05Not AvailableUs
Ranitidine Hydrochloridetablet300 mgoralREMEDYREPACK INC.2010-10-25Not AvailableUs
Ranitidine Hydrochloridetablet300 mgoralREMEDYREPACK INC.2012-01-12Not AvailableUs
Ranitidinetablet150 mgoralREMEDYREPACK INC.2010-12-06Not AvailableUs
Ranitidine Hydrochloridetablet150 mgoralREMEDYREPACK INC.2011-04-14Not AvailableUs
Ranitidine Hydrochloridetablet150 mgoralREMEDYREPACK INC.2011-08-11Not AvailableUs
Ranitidine Hydrochloridetablet300 mgoralREMEDYREPACK INC.2011-10-03Not AvailableUs
Ranitidinetablet300 mgoralPar Pharmaceutical Inc1999-01-28Not AvailableUs
Ranitidinesolution15 mg/mLoralHi Tech Pharmacal Co., Inc.2011-03-22Not AvailableUs
Ranitidinesyrup15 mg/mLoralUnit Dose Services2013-07-15Not AvailableUs
Ranitidinetablet, film coated150 mgoralUnit Dose Services2008-11-19Not AvailableUs
Ranitidinetablet, film coated300 mgoralUnit Dose Services2008-11-19Not AvailableUs
Ranitidine Hydrochloridetablet, film coated150 mgoralMylan Institutional Inc.2012-09-25Not AvailableUs
Ranitidinetablet150 mgoralNorthwind Pharmaceuticals, LLC2014-09-15Not AvailableUs
Ranitidinetablet, film coated150 mgoralREMEDYREPACK INC.2013-03-26Not AvailableUs
Ranitidinetablet, film coated150 mgoralREMEDYREPACK INC.2013-05-09Not AvailableUs
Ranitidinetablet, film coated150 mgoralREMEDYREPACK INC.2013-07-08Not AvailableUs
Ranitidine 75tablet75 mgoralREMEDYREPACK INC.2013-09-26Not AvailableUs
Ranitidinetablet150 mgoralAmneal Pharmaceuticals2009-12-16Not AvailableUs
Ranitidinetablet300 mgoralAmneal Pharmaceuticals2009-12-16Not AvailableUs
Ranitidinetablet, film coated150 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Ranitidinetablet150 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Ranitidinetablet150 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Ranitidine Hydrochloridetablet, film coated150 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Ranitidinesolution15 mg/mLoralSilarx Pharmaceuticals, Inc2010-12-10Not AvailableUs
Ranitidinetablet150 mgoralPhysicians Total Care, Inc.1999-09-21Not AvailableUs
Ranitidinetablet300 mgoralPhysicians Total Care, Inc.2003-09-19Not AvailableUs
Ranitidinesolution150 mg/mLoralPhysicians Total Care, Inc.2007-10-03Not AvailableUs
Ranitidine Hydrochloridecapsule150 mgoralDr. Reddy's Laboratories Limited2001-01-12Not AvailableUs
Ranitidine Hydrochloridecapsule300 mgoralDr. Reddy's Laboratories Limited2001-04-01Not AvailableUs
Ranitidinesyrup15 mg/mLoralDr. Reddy's Laboratories Limited2009-05-26Not AvailableUs
Ranitidinetablet150 mgoralCardinal Health2009-12-16Not AvailableUs
Ranitidinetablet150 mgoralCardinal Health2010-07-23Not AvailableUs
Ranitidinetablet150 mgoralCardinal Health2010-01-14Not AvailableUs
Ranitidinetablet, film coated150 mgoralCardinal Health2008-11-19Not AvailableUs
Ranitidine Hydrochloridetablet, film coated150 mgoralCardinal Health2011-05-20Not AvailableUs
Ranitidinetablet, film coated150 mgoralCardinal Health2009-11-06Not AvailableUs
Ranitidinetablet150 mgoralPd Rx Pharmaceuticals, Inc.2009-12-16Not AvailableUs
Ranitidinetablet, film coated300 mgoralPd Rx Pharmaceuticals, Inc.2009-11-06Not AvailableUs
Ranitidinetablet150 mgoralWockhardt Limited2009-12-11Not AvailableUs
Ranitidinesyrup15 mg/mLoralWockhardt Limited2009-05-26Not AvailableUs
Ranitidinetablet300 mgoralWockhardt Limited2009-12-11Not AvailableUs
Ranitidinetablet150 mgoralWockhardt Limited1998-12-17Not AvailableUs
Ranitidinetablet300 mgoralWockhardt Limited1998-12-17Not AvailableUs
Ranitidinesyrup15 mg/mLoralSun Pharmaceutical Industries, Inc.2011-10-03Not AvailableUs
Ranitidinetablet, film coated150 mgoralClinical Solutions Wholesale2008-11-19Not AvailableUs
Ranitidinetablet, film coated300 mgoralClinical Solutions Wholesale2008-11-19Not AvailableUs
Ranitidinetablet150 mgoralClinical Solutions Wholesale2009-12-16Not AvailableUs
Ranitidinetablet, film coated150 mgoralApotex Corp1997-09-13Not AvailableUs
Ranitidinetablet, film coated300 mgoralApotex Corp1997-09-13Not AvailableUs
Ranitidinetablet300 mgoralSt Marys Medical Park Pharmacy2014-01-30Not AvailableUs
Ranitidine Hydrochloridetablet, film coated150 mgoralREMEDYREPACK INC.2014-11-24Not AvailableUs
Ranitidine Hydrochloridetablet, film coated150 mgoralREMEDYREPACK INC.2014-10-13Not AvailableUs
Ranitidine Hydrochloridetablet150 mgoralDIRECT RX2014-01-01Not AvailableUs
Ranitidinetablet, film coated150 mgoralProficient Rx LP2008-11-19Not AvailableUs
Ranitidinetablet, film coated150 mgoralProficient Rx LP2008-11-19Not AvailableUs
Ranitidinetablet150 mgoralbryant ranch prepack2009-12-16Not AvailableUs
Ranitidine Hydrochloridetablet, film coated300 mgoralbryant ranch prepack1997-08-29Not AvailableUs
Good Sense Acid Reducertablet75 mgoralbryant ranch prepack2009-05-21Not AvailableUs
Ranitidinetablet150 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2004-07-01Not AvailableUs
Ranitidinetablet150 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2012-11-06Not AvailableUs
Ranitidinetablet150 mgoralWockhardt USA LLC.2009-12-11Not AvailableUs
Ranitidinesyrup15 mg/mLoralWOCKHARDT USA LLC2009-05-26Not AvailableUs
Ranitidinetablet300 mgoralWockhardt USA LLC.2009-12-11Not AvailableUs
Ranitidinetablet150 mgoralWOCKHARDT USA LLC1998-12-17Not AvailableUs
Ranitidinetablet300 mgoralWOCKHARDT USA LLC1998-12-17Not AvailableUs
Ranitidinesolution15 mg/mLoralAmneal Pharmaceuticals2010-03-12Not AvailableUs
Ranitidine Hydrochlorideinjection25 mg/mLintramuscular; intravenousCadila Healthcare Limited2013-03-01Not AvailableUs
Ranitidine Hydrochlorideinjection25 mg/mLintramuscular; intravenousCadila Healthcare Limited2013-03-01Not AvailableUs
Ranitidinesyrup15 mg/mLoralAurobindo Pharma Limited2010-07-28Not AvailableUs
Ranitidinetablet, film coated150 mgoralMed Vantx, Inc.1997-09-12Not AvailableUs
Ranitidinetablet150 mgoralContract Pharmacy Services Pa2010-03-11Not AvailableUs
Ranitidinetablet150 mgoralContract Pharmacy Services Pa2010-06-30Not AvailableUs
Ranitidinetablet150 mgoralAmerican Health Packaging2012-03-01Not AvailableUs
Ranitidinetablet150 mgoralAmerican Health Packaging2014-07-07Not AvailableUs
Ranitidine Hydrochloridesolution150 mg/10mLoralPrecision Dose Inc.2003-08-21Not AvailableUs
Ranitidine Hydrochloridesolution75 mg/5mLoralPrecision Dose Inc.2006-10-13Not AvailableUs
Ranitidine Hydrochloridesolution15 mg/mLoralPrecision Dose Inc.2011-04-25Not AvailableUs
Ranitidinetablet150 mgoralCarilion Materials Management2009-12-16Not AvailableUs
Ranitidine Hydrochlorideinjection25 mg/mLintramuscular; intravenousZydus Pharmaceuticals (USA) Inc.2013-03-01Not AvailableUs
Ranitidine Hydrochlorideinjection25 mg/mLintramuscular; intravenousZydus Pharmaceuticals (USA) Inc.2013-03-01Not AvailableUs
Ranitidine Hydrochloridetablet, film coated150 mgoralKeltman Pharmaceuticals Inc.2009-07-01Not AvailableUs
Ranitidinetablet, film coated150 mgoralGlenmark Generics Inc., USA2008-11-19Not AvailableUs
Ranitidinetablet, film coated300 mgoralGlenmark Generics Inc., USA2008-11-19Not AvailableUs
Ranitidinetablet300 mgoralPreferred Pharmaceuticals, Inc2012-02-27Not AvailableUs
Ranitidinetablet150 mgoralPreferred Pharmaceuticals, Inc2012-02-27Not AvailableUs
Ranitidinetablet, film coated150 mgoralMc Kesson Contract Packaging2011-10-26Not AvailableUs
Ranitidinetablet150 mgoralSanis Health IncNot AvailableNot AvailableCanada
Ranitidinetablet300 mgoralSanis Health IncNot AvailableNot AvailableCanada
Ranitidinetablet150 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Ranitidinetablet300 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acid Reducer Maximum Strengthtablet150 mgoralL. Perrigo Company2008-02-19Not AvailableUs
Good Sense Acid Reducertablet75 mgoralL Perrigo Company2009-05-21Not AvailableUs
Good Sense Acid Reducertablet, film coated150 mgoralL. Perrigo Company2008-02-19Not AvailableUs
Good Sense Acid Reducertablet, film coated150 mgoralL Perrigo Company2011-10-21Not AvailableUs
Wal Zan Acid Reducer maximum strengthtablet150 mgoralWalgreen Company2008-02-04Not AvailableUs
Wal Zan 75tablet75 mgoralWalgreen Company2009-02-24Not AvailableUs
Ranitidinetablet, film coated75 mgoralWalgreen Company2013-09-24Not AvailableUs
Wal-zantablet150 mgoralWalgreen Company2011-06-28Not AvailableUs
Wal Zan 150tablet, film coated150 mgoralWalgreen Company2011-09-17Not AvailableUs
Ranitidinetablet, film coated150 mgoralLiberty Pharmaceuticals, Inc.2013-07-15Not AvailableUs
Zantac Maximum Strength 150 Cool Minttablet, coated150 mgoralBoehringer Ingelheim Pharmaceuticals Inc.2006-12-21Not AvailableUs
Maximum Strength Zantactablet, coated150 mgoralBoehringer Ingelheim Pharmaceuticals Inc.2006-12-21Not AvailableUs
Zantac 75tablet, coated75 mgoralBoehringer Ingelheim Pharmaceuticals Inc.2006-12-21Not AvailableUs
Ranitidine 75tablet75 mgoralMajor Pharmaceuticals2009-05-26Not AvailableUs
Major Ranitidine Maximum Strengthtablet150 mgoralMajor Pharmaceuticals2008-02-18Not AvailableUs
Ranitidinetablet, film coated75 mgoralMajor Pharmaceuticals2013-10-01Not AvailableUs
Acid Reducertablet150 mgoralMajor Pharmaceuticals2013-10-01Not AvailableUs
Formu Care Ranitidinetablet150 mgoralAccess Business Group LLC2010-09-24Not AvailableUs
Formucare Ranitidinetablet75 mgoralAccess Business Group International LLC2009-09-09Not AvailableUs
7 Select Acid Reducertablet, film coated150 mgoral7 Eleven2014-04-22Not AvailableUs
Acid Reducertablet150 mgoralRite Aid Corporation2008-12-03Not AvailableUs
Acid Reducertablet75 mgoralRite Aid Corporation2011-11-04Not AvailableUs
Acid Reducertablet, film coated150 mgoralRite Aid Corporation2009-04-20Not AvailableUs
Cool Mint Acid Reducertablet, film coated150 mgoralRite Aid Corporation2011-12-07Not AvailableUs
Non-prescription Strength Acid Reducertablet75 mgoralRite Aid2013-06-15Not AvailableUs
Acid Reducertablet150 mgoralSelect Brand2012-03-30Not AvailableUs
Ranitidine Hydrochloridetablet, film coated75 mgoralSelect Brand2012-07-10Not AvailableUs
Acid Reducertablet150 mgoralSafeway2008-02-20Not AvailableUs
Acid Reducertablet75 mgoralSafeway2009-05-29Not AvailableUs
Acid Reducer 150tablet, film coated150 mgoralSafeway2011-09-29Not AvailableUs
Good Neighbor Pharmacy Acid Control 150 Maximum Strengthtablet150 mgoralAmerisource Bergen2008-02-19Not AvailableUs
Good Neighbor Pharmacy Acid Controltablet75 mgoralAmerisource Bergen2009-05-16Not AvailableUs
Heartburn Relieftablet150 mgoralKroger Company2008-02-25Not AvailableUs
Heartburn Relief Acid Reducertablet75 mgoralKroger Company2009-05-22Not AvailableUs
Heartburn Relieftablet, film coated150 mgoralKroger Company2013-08-31Not AvailableUs
Heartburn Relieftablet, film coated150 mgoralKroger Company2011-09-20Not AvailableUs
Maximum Strength Heartburn Relieftablet150 mgoralGreenbrier International, Inc.2013-06-15Not AvailableUs
Topcare Heartburn Relief 150tablet150 mgoralTopco Associates LLC2008-02-13Not AvailableUs
Topcare Heartburn Relieftablet75 mgoralTopco Associates LLC2009-06-11Not AvailableUs
Topcare Heartburn Relief 150tablet, film coated150 mgoralTopco Associates LLC2008-02-15Not AvailableUs
Topcare Heartburn Relief 150tablet, film coated150 mgoralTopco Associates LLC2011-10-10Not AvailableUs
Acid Reducertablet150 mgoralShopko Stores Operating Co., LLC2013-06-05Not AvailableUs
Ranitidinetablet150 mgoralShopko Stores Operating Co., LLC.2010-07-11Not AvailableUs
Acid Reducertablet75 mgoralShopko Stores Operating Co., LLC2013-06-10Not AvailableUs
Ranitidinetablet150 mgoralShopko Stores Operating Co., LLC2012-03-30Not AvailableUs
Acid Reducertablet, film coated150 mgoralShopko Stores Operating Co., LLC2013-06-05Not AvailableUs
Acid Reducertablet, film coated150 mgoralShopko Stores Operating Co., LLC2013-06-05Not AvailableUs
Leader Acid Control Acid Reducertablet75 mgoralCardinal Health2009-05-21Not AvailableUs
Leader Acid Controltablet, film coated150 mgoralCardinal Health2011-11-11Not AvailableUs
Leader Acid Control Maximum Strengthtablet150 mgoralCardinal Health2008-02-20Not AvailableUs
Leader Acid Controltablet, film coated150 mgoralCardinal Health2011-11-11Not AvailableUs
Rx Act Heartburn Relieftablet150 mgoralH E B2008-02-20Not AvailableUs
Acid Reducertablet150 mgoralH E B2014-04-11Not AvailableUs
Heartburn Relieftablet, film coated150 mgoralH E B2013-07-23Not AvailableUs
Heartburn Relieftablet, film coated150 mgoralH E B2011-11-25Not AvailableUs
Maximum Strength Heartburn Relieftablet150 mgoralSUPERVALU INC.2013-06-15Not AvailableUs
Equaline Heartburn Relieftablet75 mgoralSupervalu Inc2009-05-11Not AvailableUs
Heartburn Relieftablet75 mgoralSUPERVALU INC.2013-06-15Not AvailableUs
Equaline Heartburn Relieftablet, film coated150 mgoralSupervalu Inc2012-07-25Not AvailableUs
Shoprite Acid Reducertablet150 mgoralWakefern Food Corporation2013-06-16Not AvailableUs
Shoprite Acid Reducer Maximum Strengthtablet, film coated150 mgoralWakefern Food Corporation2013-06-16Not AvailableUs
Shoprite Acid Reducertablet, film coated150 mgoralWakefern Food Corporation2013-06-20Not AvailableUs
Acid Reducer maximum strengthtablet150 mgoralMeijer Distribution Inc2008-02-13Not AvailableUs
Acid Reducertablet75 mgoralMeijer Distribution Inc1998-09-29Not AvailableUs
Acid Reducertablet, film coated150 mgoralMeijer Distribution Inc2013-08-23Not AvailableUs
Acid Reducertablet, film coated150 mgoralMeijer Distribution Inc2011-09-21Not AvailableUs
Acid Reducertablet75 mgoralHannaford Brothers Company2009-08-11Not AvailableUs
Care One Acid Reducertablet150 mgoralAmerican Sales Company2008-02-13Not AvailableUs
Careone Acid Reducertablet75 mgoralAmerican Sales Company2009-05-29Not AvailableUs
Careone Acid Reducertablet, film coated150 mgoralAmerican Sales Company2013-11-30Not AvailableUs
Careone Acid Reducertablet, film coated150 mgoralAmerican Sales Company2013-09-22Not AvailableUs
Acid Reducer maximum strengthtablet150 mgoralHy Vee Inc2008-02-17Not AvailableUs
Acid Reducertablet75 mgoralHy Vee Inc2009-11-23Not AvailableUs
Ranitidine Acid Reducertablet, film coated150 mgoralHy Vee Inc2013-12-02Not AvailableUs
Acid Reducer 150tablet, film coated150 mgoralHy Vee Inc2012-09-17Not AvailableUs
Good Neighbor Pharmacy Acid Control 150tablet, film coated150 mgoralAmerisource Bergen2011-10-04Not AvailableUs
Ranitidinetablet, film coated75 mgoralAmerisource Bergen2013-09-06Not AvailableUs
Good Neighbor Pharmacy Acid Control 150tablet, film coated150 mgoralAmerisource Bergen2008-02-19Not AvailableUs
Being Well Heartburn Relief acid reducertablet150 mgoralSave A Lot Food Stores Ltd2010-03-23Not AvailableUs
Being Well Heartburn Relieftablet, film coated150 mgoralSave A Lot Food Stores Ltd2013-09-09Not AvailableUs
Acid Reducertablet150 mgoralWal Mart Stores, Inc2013-09-09Not AvailableUs
Ranitidinetablet, film coated75 mgoralWal Mart Stores, Inc2012-07-10Not AvailableUs
Equate Ranitidinetablet, film coated150 mgoralWal Mart Stores Inc2012-02-12Not AvailableUs
Equate Ranitidine Acid Reducertablet, film coated150 mgoralWal Mart Stores Inc2013-02-22Not AvailableUs
Equate Acid Reducertablet, film coated150 mgoralWal Mart Stores Inc2012-02-12Not AvailableUs
Acid Reducertablet150 mgoralMc Kesson2014-01-07Not AvailableUs
Ranitidinetablet, film coated75 mgoralSunmark2013-09-20Not AvailableUs
Sunmark Acid Reducertablet75 mgoralMc Kesson2009-07-10Not AvailableUs
Sunmark Acid Reducer Maximum Strengthtablet150 mgoralMc Kesson2008-02-13Not AvailableUs
Acid Reducertablet75 mgoralMedicine Shoppe International Inc2009-06-11Not AvailableUs
Smart Sense Acid Reducertablet150 mgoralKmart Corporation2010-11-24Not AvailableUs
Smart Sense Ranitidinetablet150 mgoralKmart Corporation2010-11-24Not AvailableUs
Smart Sense Acid Reducertablet75 mgoralKmart Corporation2010-12-15Not AvailableUs
Smart Sense Ranitidinetablet, film coated150 mgoralKmart Corporation2014-03-21Not AvailableUs
Smart Sense Ranitidinetablet, film coated150 mgoralKmart Corporation2010-11-24Not AvailableUs
Acid Reducer Regular Strengthtablet75 mgoralKmart Corporation2013-06-15Not AvailableUs
Smart Sense Acid Reducertablet, film coated150 mgoralKmart Corporation2011-11-22Not AvailableUs
Ranitidinetablet, film coated75 mgoralCardinal Health2013-09-25Not AvailableUs
Acid Reducertablet150 mgoralCardinal Health2013-09-25Not AvailableUs
Leader Acid Controltablet, film coated150 mgoralCardinal Health2008-02-20Not AvailableUs
Leader Acid Controltablet, film coated150 mgoralCardinal Health2014-03-11Not AvailableUs
Acid Reducertablet, film coated75 mgoralGood Sense2013-10-11Not AvailableUs
Regular Strength Acid Reducertablet75 mgoralL.N.K. International, Inc.2013-06-15Not AvailableUs
Maximum Strength Acid Reducertablet150 mgoralL.N.K. International, Inc.2013-06-15Not AvailableUs
Acid Reducertablet150 mgoralOhm Laboratories Inc.2011-06-28Not AvailableUs
Ranitidinetablet150 mgoralMedline Industries, Inc.2012-03-30Not AvailableUs
Ranitidinetablet75 mgoralDr. Reddy's Laboratories Limited2000-03-01Not AvailableUs
Ranitidine Hydrochloridetablet, coated168 mgoralDr. Reddy's Laboratories Limited2009-12-02Not AvailableUs
Exchange Select Acid Reducertablet75 mgoralArmy & Air Force Exchange Service2012-09-12Not AvailableUs
Exchange Select Acid Reducertablet, film coated150 mgoralArmy & Air Force Exchange Service2014-01-06Not AvailableUs
Acid Reducertablet150 mgoralWestern Family Foods Inc2008-03-14Not AvailableUs
Acid Relieftablet75 mgoralWestern Family Foods Inc2009-05-28Not AvailableUs
Acid Relieftablet, film coated150 mgoralWestern Family Foods Inc2013-11-27Not AvailableUs
Acid Relieftablet, film coated150 mgoralWestern Family Foods Inc2011-10-03Not AvailableUs
Acid Reducertablet150 mgoralFred's Inc.2012-03-30Not AvailableUs
Ranitidinetablet, film coated75 mgoralFred's Inc.2013-09-01Not AvailableUs
Healthy Accents Ranitidinetablet150 mgoralDZA Brands LLC2008-11-12Not AvailableUs
Healthy Accents Ranitidinetablet, film coated150 mgoralDZA Brands LLC2013-10-09Not AvailableUs
Family Wellness Acid Reducertablet75 mgoralFamily Dollar Services Inc2012-08-02Not AvailableUs
Regular Strength Acid Reducertablet150 mgoralFamily Dollar2011-06-28Not AvailableUs
Regular Strength Acid Reducertablet75 mgoralFamily Dollar2013-09-24Not AvailableUs
Regular Strength Acid Reducertablet75 mgoralFamily Dollar2013-06-15Not AvailableUs
Maximum Strength Acid Reducertablet150 mgoralFamily Dollar2013-06-15Not AvailableUs
Ranitidinetablet, coated75 mgoralWockhardt Limited2008-07-31Not AvailableUs
Ranitidinetablet, coated150 mgoralWockhardt Limited2007-11-26Not AvailableUs
Dg Health Acid Reducer Maximum Strengthtablet150 mgoralDolgencorp Inc2010-02-06Not AvailableUs
Dg Health Acid Reducertablet75 mgoralDolgencorp Inc2010-03-27Not AvailableUs
Dg Health Acid Reducertablet, film coated150 mgoralDolgencorp, LLC2013-08-29Not AvailableUs
Rexall Heartburn Relieftablet, film coated150 mgoralDolgencorp, LLC2011-10-03Not AvailableUs
Maximum Strengthtablet150 mgoralPublix Super Markets Inc2009-01-27Not AvailableUs
Acid Reducertablet75 mgoralPublix Super Markets Inc2009-06-08Not AvailableUs
Maximum Strength Ranitidinetablet, film coated150 mgoralPublix Super Markets Inc2013-11-25Not AvailableUs
Maximum Strength Heartburn Relief 150tablet150 mgoralSalado Sales, Inc.2013-06-15Not AvailableUs
Ranitidinetablet150 mgoralShasun Pharmaceuticals Limited2011-06-28Not AvailableUs
Ranitidinetablet75 mgoralShasun Pharmaceuticals Limited2012-02-29Not AvailableUs
Acid Reducertablet150 mgoralP and L Development of New York Corporation2013-03-25Not AvailableUs
Ranitidinetablet75 mgoralP and L Development of New York Corporation2013-03-19Not AvailableUs
Acid Reducertablet150 mgoralCVS Pharmacy2012-08-21Not AvailableUs
Ranitidinetablet, film coated75 mgoralCVS Pharmacy, Inc2013-09-19Not AvailableUs
Acid Reducertablet, film coated150 mgoralCVS Pharmacy2011-09-21Not AvailableUs
Ranitidinetablet, film coated150 mgoralApotex Corp.2013-07-15Not AvailableUs
Ranitidinetablet, film coated75 mgoralApotex Corp.2005-01-24Not AvailableUs
Acid Reducertablet150 mgoralPreferred Plus (Kinray)2014-01-27Not AvailableUs
Acid Reducertablet, film coated75 mgoralPreferred Plus (Kinray)2014-01-27Not AvailableUs
Health Mart Acid Reducertablet75 mgoralMc Kesson2012-03-20Not AvailableUs
Health Mart Acid Reducertablet150 mgoralMc Kesson2012-03-20Not AvailableUs
Health Mart Acid Reducertablet, film coated150 mgoralMcKesson2012-03-20Not AvailableUs
Ranitidinetablet, film coated75 mgoralHealth Mart2013-09-20Not AvailableUs
Acid Reducertablet150 mgoralMc Kesson2014-01-07Not AvailableUs
Acid Reducertablet150 mgoralChain Drug Marketing Association Inc.2012-03-30Not AvailableUs
Ranitidinetablet, film coated75 mgoralChain Drug Marketing Association Inc.2012-07-10Not AvailableUs
Ranitidinetablet, film coated75 mgoralValu Merchandisers Company2012-07-10Not AvailableUs
Kirkland Signature Acid Reducertablet, film coated150 mgoralCostco Wholesale Company2013-04-24Not AvailableUs
Ranitidinetablet, coated75 mgoralWockhardt USA LLC.2008-07-31Not AvailableUs
Ranitidinetablet, coated150 mgoralWockhardt USA LLC.2007-11-26Not AvailableUs
Zantac 150 Acid Reducertablet150 mgoralLil' Drug Store Products, Inc2010-11-01Not AvailableUs
Acid Reducertablet150 mgoralWin Co Foods, Llc2012-08-15Not AvailableUs
Acid Reducertablet150 mgoralPremier Value2012-03-30Not AvailableUs
Zantac 75tablet, coated75 mgoralCarilion Materials Management2006-12-21Not AvailableUs
Acid Reducertablet150 mgoralNash Finch Company2013-06-15Not AvailableUs
International Brands
NameCompany
AlquenNot Available
CoralenNot Available
GastrolavNot Available
GastrosedolNot Available
KuracidNot Available
Nu-RanitNot Available
Pep-RaniNot Available
PtinolinNot Available
RaniberlNot Available
RaniblocNot Available
RanicuxNot Available
RanidilNot Available
RanidinNot Available
RanidineNot Available
RaniduraNot Available
RanifurNot Available
RanigastNot Available
RaniplexNot Available
RanisanNot Available
RanitabNot Available
RaniticNot Available
RanitidinNot Available
RanitinNot Available
RanitineNot Available
RanobelNot Available
RantacidNot Available
RanuberNot Available
RenatacNot Available
SostrilNot Available
TanidinaNot Available
ToriolNot Available
UlcodinNot Available
ZandidNot Available
ZanticNot Available
Brand mixtures
Brand NameIngredients
Tritecranitidine +bismuth + citrate salt
Salts
Name/CASStructureProperties
Ranitidine Hydrochloride
66357-59-3
Thumb
  • InChI Key: GGWBHVILAJZWKJ-KJEVSKRMSA-N
  • Monoisotopic Mass: 350.117939019
  • Average Mass: 350.865
DBSALT000487
Categories
CAS number66357-35-5
WeightAverage: 314.404
Monoisotopic: 314.14126128
Chemical FormulaC13H22N4O3S
InChI KeyVMXUWOKSQNHOCA-UKTHLTGXSA-N
InChI
InChI=1S/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+
IUPAC Name
dimethyl[(5-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}furan-2-yl)methyl]amine
SMILES
CN\C(NCCSCC1=CC=C(CN(C)C)O1)=C/[N+]([O-])=O
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassHeterocyclic Compounds
ClassFurans
SubclassNot Available
Direct parentFurans
Alternative parentsNitro Compounds; Tertiary Amines; Nitronic Acids; Polyamines; Organic Oxoazanium Compounds; Thioethers
Substituentsnitronic acid; nitro compound; tertiary amine; organic oxoazanium; polyamine; thioether; amine; organonitrogen compound
Classification descriptionThis compound belongs to the furans. These are compounds containing a furan ring, which is a five-member aromatic ring with one oxygen atom, four carbon atoms.
Pharmacology
IndicationUsed in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
PharmacodynamicsRanitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Mechanism of actionThe H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.
AbsorptionApproximately 50% bioavailability orally.
Volume of distribution
  • 1.4 L/kg
  • 1.76 L/kg [clinically significant renal function impairment (creatinine clearance 25 to 35 mL/min)]
Protein binding15%
Metabolism

Hepatic. Ranitidine is metabolized to the N-oxide, S-oxide, and N-desmethyl metabolites, accounting for approximately 4%, 1%, and 1% of the dose, respectively.

Route of eliminationThe principal route of excretion is the urine (active tubular excretion, renal clearance 410mL/min), with approximately 30% of the orally administered dose collected in the urine as unchanged drug in 24 hours.
Half life2.8-3.1 hours
Clearance
  • 29 mL/min [clinically significant renal function impairment]
  • 3 mL/min/Kg [neonatal patients]
ToxicityLD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption + 0.9936
Blood Brain Barrier - 0.8783
Caco-2 permeable - 0.5838
P-glycoprotein substrate Substrate 0.8527
P-glycoprotein inhibitor I Non-inhibitor 0.8782
P-glycoprotein inhibitor II Non-inhibitor 0.8893
Renal organic cation transporter Non-inhibitor 0.8177
CYP450 2C9 substrate Non-substrate 0.7702
CYP450 2D6 substrate Substrate 0.7414
CYP450 3A4 substrate Non-substrate 0.5565
CYP450 1A2 substrate Non-inhibitor 0.9046
CYP450 2C9 substrate Non-inhibitor 0.9071
CYP450 2D6 substrate Non-inhibitor 0.923
CYP450 2C19 substrate Non-inhibitor 0.9025
CYP450 3A4 substrate Non-inhibitor 0.8308
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.7819
Ames test Non AMES toxic 0.9132
Carcinogenicity Non-carcinogens 0.8077
Biodegradation Not ready biodegradable 0.9249
Rat acute toxicity 2.0903 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Strong inhibitor 0.8628
hERG inhibition (predictor II) Non-inhibitor 0.8734
Pharmacoeconomics
Manufacturers
  • Dr reddys laboratories ltd
  • Genpharm inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Glaxosmithkline
  • Bedford laboratories div ben venue laboratories inc
  • Ben venue laboratories inc
  • Alpharma us pharmaceuticals division
  • Amneal pharmaceuticals
  • Apotex inc
  • Aurobindo pharma usa inc
  • Cypress pharmaceutical inc
  • Pharmaceutical assoc inc div beach products
  • Ranbaxy laboratories ltd
  • Vintage pharmaceuticals inc
  • Wockhardt ltd
  • Boehringer ingelheim pharmaceuticals inc
  • Amneal pharmaceuticals ny llc
  • Boehringer ingelheim corp
  • Contract pharmacal corp
  • Dr reddys laboratories inc
  • Glenmark generics inc usa
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Par pharmaceutical inc
  • L perrigo co
  • Ranbaxy pharmaceuticals inc
  • Torpharm inc
  • Watson laboratories inc
  • Wockhardt americas inc
  • Boehringer ingelheim
Packagers
Dosage forms
FormRouteStrength
Capsuleoral150 mg
Capsuleoral300 mg
Injectionintramuscular; intravenous25 mg/mL
Injection, solutionintramuscular; intravenous25 mg/mL
Solutionintramuscular25 mg
Solutionoral15 mg/mL
Solutionoral150 mg/10mL
Solutionoral150 mg/mL
Solutionoral75 mg/5mL
Syruporal15 mg/mL
Syruptopical15 mg/mL
Tabletoral150 mg
Tabletoral300 mg
Tabletoral75 mg
Tablet, coatedoral150 mg
Tablet, coatedoral168 mg
Tablet, coatedoral75 mg
Tablet, film coatedoral150 mg
Tablet, film coatedoral300 mg
Tablet, film coatedoral75 mg
Prices
Unit descriptionCostUnit
Zantac 300 mg tablet7.96USDtablet
Ranitidine hcl powder5.2USDg
Zantac EFFERdose 25 mg Effervescent Tabs4.18USDtab
Zantac 25 efferdose tablet4.02USDtablet
Zantac 150 mg tablet3.11USDtablet
Ranitidine HCl 300 mg capsule2.85USDcapsule
Ranitidine HCl 300 mg tablet2.79USDtablet
Ranitidine 300 mg tablet2.69USDtablet
Ranitidine hcl 25 mg/ml vial2.0USDml
Zantac 25 mg/ml vial2.0USDml
Ranitidine HCl 150 mg capsule1.58USDcapsule
Zantac 25 mg/ml1.58USDml
Ranitidine HCl 150 mg tablet1.54USDtablet
Ranitidine 150 mg tablet1.48USDtablet
Ranitidine 25 mg/ml1.26USDml
Ranitidine HCl 15 mg/ml Syrup1.0USDml
Ratio-Ranitidine 300 mg Tablet0.82USDtablet
Apo-Ranitidine 300 mg Tablet0.82USDtablet
Co Ranitidine 300 mg Tablet0.82USDtablet
Mylan-Ranitidine 300 mg Tablet0.82USDtablet
Nu-Ranit 300 mg Tablet0.82USDtablet
Pms-Ranitidine 300 mg Tablet0.82USDtablet
Ran-Ranitidine 300 mg Tablet0.82USDtablet
Zantac 15 mg/ml Syrup0.81USDml
Zantac 75 tablet0.49USDtablet
Apo-Ranitidine 150 mg Tablet0.42USDtablet
Co Ranitidine 150 mg Tablet0.42USDtablet
Mylan-Ranitidine 150 mg Tablet0.42USDtablet
Nu-Ranit 150 mg Tablet0.42USDtablet
Pms-Ranitidine 150 mg Tablet0.42USDtablet
Ran-Ranitidine 150 mg Tablet0.42USDtablet
Ratio-Ranitidine 150 mg Tablet0.42USDtablet
Novo-Ranidine 300 mg Tablet0.38USDtablet
Phl-Ranitidine 300 mg Tablet0.38USDtablet
Sandoz Ranitidine 300 mg Tablet0.38USDtablet
Zantac 300 mg Tablet0.38USDtablet
Zantac 75 mg tablet0.28USDtablet
Wal-zan 75 mg tablet0.27USDtablet
Zantac 15 mg/ml Solution0.23USDml
Ranitidine hcl 75 mg tablet0.22USDtablet
Sm acid reducer 75 mg tablet0.22USDtablet
Acid reducer 150 mg tablet0.2USDtablet
Wal-zan 75 tablet0.2USDtablet
Novo-Ranidine 150 mg Tablet0.19USDtablet
Phl-Ranitidine 150 mg Tablet0.19USDtablet
Sandoz Ranitidine 150 mg Tablet0.19USDtablet
Zantac 150 mg Tablet0.19USDtablet
CVS Pharmacy ranitidine 75 mg tablet0.15USDtablet
Apo-Ranitidine 15 mg/ml Solution0.12USDml
Novo-Ranidine 15 mg/ml Solution0.12USDml
Acid reducer 75 mg tablet0.11USDtablet
CVS Pharmacy acid reducer 75 mg tablet0.11USDtablet
Qc ranitidine 75 mg tablet0.07USDtablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada13326101994-10-182011-10-18
United States50987151993-12-202010-12-20
United States51026651992-12-232009-12-23
Properties
Statesolid
Experimental Properties
PropertyValueSource
melting point69-70 °CPhysProp
water solubility24.7 mg/mLNot Available
logP0.27SANGSTER (1993)
Caco2 permeability-6.31ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.0795ALOGPS
logP0.79ALOGPS
logP0.98ChemAxon
logS-3.6ALOGPS
pKa (Strongest Basic)8.08ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area86.26 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity95.15 m3·mol-1ChemAxon
Polarizability33.58 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
SpectraMS/MSLC-MS1D NMR2D NMR
References
Synthesis Reference

John W. Clitherow, “Intermediates in the preparation of ranitidine.” U.S. Patent US4413135, issued November, 1981.

US4413135
General ReferenceNot Available
External Links
ResourceLink
KEGG DrugD00422
PubChem Compound3001055
PubChem Substance46505543
ChemSpider2272523
BindingDB22893
ChEBI8776
ChEMBLCHEMBL1790041
Therapeutic Targets DatabaseDAP000340
PharmGKBPA451224
IUPHAR1234
Guide to Pharmacology1234
RxListhttp://www.rxlist.com/cgi/generic2/ranitbc.htm
Drugs.comhttp://www.drugs.com/ranitidine.html
WikipediaRanitidine
ATC CodesA02BA02A02BA07
AHFS Codes
  • 56:28.12
PDB EntriesNot Available
FDA labelshow(247 KB)
MSDSshow(73.9 KB)
Interactions
Drug Interactions
Drug
AcenocoumarolRanitidine may increase the anticoagulant effect of acenocoumarol. (Conflicting evidence)
AnisindioneRanitidine may increase the anticoagulant effect of anisindione. (Conflicting evidence)
AtazanavirRanitidine may decrease the levels/effects of atazanavir.
CefditorenH2-Antagonists such as ranitidine may decrease the serum concentration of cefditoren. Cefditoren prescribing information recommends to avoid concomitant use with H2-antagonists (eg, famotidine, ranitidine) and antacids as well. Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of H2-antagonists can not be avoided.
DabrafenibH2-receptor antagonists may alter the solubility of dabrafenib and reduce its bioavailability.
DasatinibRanitidine may decrease the serum level of dasatinib.
DicoumarolRanitidine may increase the anticoagulant effect of dicumarol. (Conflicting evidence)
ItraconazoleThe H2-receptor antagonist, ranitidine, may decrease the absorption of itraconazole.
KetoconazoleThe H2-receptor antagonist, ranitidine, may decrease the absorption of ketoconazole.
ProcainamideThe histamine H2-receptor antagonist, ranitidine, may increase the effect of procainamide.
RilpivirineHistamine-2 receptor antagonists increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
TolazolineAnticipated loss of efficacy of tolazoline
VismodegibVismodegib serum concentrations may be decreased by histamine 2 receptor antagonists such as ranitidine.
WarfarinRanitidine may increase the anticoagulant effect of warfarin. (Conflicting evidence)
Food Interactions
  • Avoid alcohol.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take without regard to meals.

Targets

1. Histamine H2 receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Histamine H2 receptor P25021 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Pattichis K, Louca LL: Histamine, histamine H2-receptor antagonists, gastric acid secretion and ulcers: an overview. Drug Metabol Drug Interact. 1995;12(1):1-36. Pubmed

Enzymes

1. Cytochrome P450 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

2. Cytochrome P450 2C19

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 2D6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

4. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

5. Cytochrome P450 3A5

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A5 P20815 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Transporters

1. Solute carrier family 22 member 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 1 O15245 Details

References:

  1. Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. Pubmed

2. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE: Influence of passive permeability on apparent P-glycoprotein kinetics. Pharm Res. 2000 Dec;17(12):1456-60. Pubmed
  2. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. Pubmed
  3. Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. Pubmed
  4. Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. Pubmed

3. Solute carrier family 22 member 8

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Solute carrier family 22 member 8 Q8TCC7 Details

References:

  1. Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y: Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther. 2006 Mar;316(3):1187-94. Epub 2005 Nov 16. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:12