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Identification
NameChlorhexidine
Accession NumberDB00878  (APRD00545)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionA disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. [PubChem]
Structure
Thumb
Synonyms
1,1'-Hexamethylene bis(5-(P-chlorophenyl)biguanide)
Chlorhexidin
Chlorhexidine
Chlorhexidinum
Cloresidina
Clorhexidina
N,N'-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Antiseptic Skin Cleansersolution4 g/100mLtopicalCardinal Health2012-01-01Not applicableUs
Betaseptsolution.04 mg/mLtopicalPurdue Products LP1993-06-01Not applicableUs
Chlorhexidine Gluconate 0.12% Oral Rinse, USPliquid; mouthwash/gargle0.12 %oralSage Products LLC2016-02-03Not applicableCanada
Chlorhexidine Gluconate 0.12% Oral Rinse, USPliquid; mouthwash/gargle0.12 %oralXttrium Laboratories Inc.Not applicableNot applicableCanada
Denti-care Chlorhexidine Gluconate Oral Rinse 0.12%liquid; mouthwash/gargle0.12 %buccal; oralA.R. Medicom Inc.1999-11-26Not applicableCanada
E-Z Scrub 107sponge4 %topicalBecton DickinsonNot applicableNot applicableCanada
Gum Paroexmouthwash/gargle0.12 %buccalSunstar Americas Inc2012-10-01Not applicableCanada
Oro Clearliquid0.12 %buccalGermiphene Corporation2016-01-25Not applicableCanada
Oro-clense Oral Rinse - Liq 0.12%liquid0.12 %buccalGermiphene Corporation1996-12-31Not applicableCanada
Perichlorliquid0.12 %buccalPharmascience Inc2000-02-09Not applicableCanada
Peridexrinse1.2 mg/mLoral3 M Espe Dental Products1986-08-13Not applicableUs
Peridex Oral Rinseliquid; mouthwash/gargle0.12 %buccal3 M Canada Company1998-08-31Not applicableCanada
Peridex Oral Rinse 0.12%liquid; mouthwash/gargle0.12 %buccalProcter & Gamble Inc1994-12-311999-08-04Canada
Periochipinsert, extended release2.5 mg/1periodontalAdrian Pharmaceuticals, LLC1998-05-01Not applicableUs
Periochipinsert, extended release2.5 mg/1periodontalDexcel Pharma Technologies Ltd.1998-05-01Not applicableUs
Periogardliquid0.12 %buccal; oralColgate Palmolive Canada Inc1996-10-30Not applicableCanada
Periogard Alcohol Freesolution0.12 %buccalColgate Palmolive Canada IncNot applicableNot applicableCanada
Prevora Stage 1solution; kit10 %dentalChx Technologies Inc1993-12-31Not applicableCanada
Pro-dentx Chlorhexidene Oral Rinseliquid0.12 %buccalPdt Image Inc. Dba Pro Dentec Canada2000-06-052009-06-15Canada
Seaqua Xlotion2.0 %topicalSeaford Pharmaceuticals IncNot applicableNot applicableCanada
X-pur Chlorhexidineliquid0.12 %buccalPharmascience Inc2009-09-14Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acclean Chlorhexidine Gluconate 0.12% Oral Rinseliquid.12 mg/mLoralHenry Schein, Inc.2009-10-01Not applicableUs
Acclean Chlorhexidine Gluconate 0.12% Oral Rinseliquid.12 mg/mLoralHenry Schein, Inc.2013-02-01Not applicableUs
Apo-chlorhexidine Oral Rinseliquid0.12 %oralApotex Inc2000-08-29Not applicableCanada
Chlorhexidine Gluconaterinse1.2 mg/mLoralLLC Federal Solutions2013-06-24Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralXttrium Laboratories, Inc.2009-08-01Not applicableUs
Chlorhexidine Gluconaterinse1.2 mg/mLoralDen Mat Holdings, Llc2009-06-18Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralMedline Industries, Inc.2010-08-05Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralProficient Rx LP2009-08-01Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralCarilion Materials Management2009-08-01Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralAtlantic Biologicals Corps2009-08-01Not applicableUs
Chlorhexidine Gluconaterinse1.2 mg/mLoralHi Tech Pharmacal Co., Inc.1996-05-07Not applicableUs
Chlorhexidine Gluconateliquid.12 mg/mLoralPatterson Dental Supply Inc.2016-01-22Not applicableUs
Chlorhexidine Gluconaterinse1.2 mg/mLoralProficient Rx LP1996-05-07Not applicableUs
Chlorhexidine Gluconaterinse1.2 mg/mLoralPreferred Pharmaceuticals, Inc.2014-04-21Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralAtlantic Biologicals Corps2009-08-01Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralUnit Dose Services2009-08-01Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralPhysicians Total Care, Inc.1998-03-24Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralPreferred Pharmaceuticals, Inc.2013-10-22Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralRebel Distributors Corp2009-08-01Not applicableUs
Chlorhexidine Gluconaterinse.12 mg/mLoralBenco Dental2012-04-01Not applicableUs
Chlorhexidine Gluconaterinse1.2 mg/mLoralCardinal Health1996-05-07Not applicableUs
Chlorhexidine Gluconate 0.12% Oral Rinseliquid1.2 [iU]/mLbuccalSage Products LLC2014-01-20Not applicableUs
Denti-care Denti-rinse Chlorhexidine Gluconate Oral Rinseliquid.12 g/mLdentalAr Medicom Inc.2006-06-02Not applicableUs
Paroexrinse1.2 mg/mLoralSunstar Americas, Inc.2014-10-31Not applicableUs
Periogardrinse1.2 mg/mLbuccalColgate Oral Pharmaceuticals, Inc.1998-01-01Not applicableUs
Periogard Alcohol Freerinse1.2 mg/mLbuccalColgate Oral Pharmaceuticals, Inc.2016-01-29Not applicableUs
Superdent Chlorhexidine Gluconate Oral Rinseliquid.12 g/100mLdentalDarby Dental Supply, LLC2006-07-02Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Antiseptic Body Cleanserwipe2 %topicalSage Products LLC2006-02-14Not applicableCanada
Antiseptic Cleanser Solutionsolution2 %topicalNiagara Pharmaceuticals Inc.1996-08-202016-05-12Canada
Antiseptic First Aid Sprayliquid2 %topicalWasip Ltd.2007-06-112016-07-14Canada
Antiseptic Lotion Soap 2%lotion2 %topicalGOJO Industries, Inc.1997-08-132002-09-09Canada
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalWALGREEN CO.2011-05-01Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalRite Aid Corporation2013-01-01Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalMeijer Distribution, Inc.2014-01-01Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalChain Drug Marketing Association Inc.2014-05-01Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalTopco Associates LLC2013-11-01Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalKinray Inc.2013-08-03Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalChain Drug Consortium, LLC2012-10-30Not applicableUs
Antiseptic Skin Cleansersolution4 g/100mLtopicalXttrium Laboratories, Inc.2011-08-31Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalAmerisource Bergen Drug Corporation2013-04-01Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalMc Kesson2014-02-20Not applicableUs
Antiseptic Skin Cleanserliquid4 mg/100mLtopicalMc Kesson2014-02-20Not applicableUs
Antiseptic Skin Cleanserliquid2 %topicalCanadian Custom Packaging Company2009-09-23Not applicableCanada
Aplicare Antiseptic Chlorhexidine Gluconatesolution4 g/100mLtopicalAplicare, Inc.1998-09-01Not applicableUs
Aplicare Antiseptic Chlorhexidine Gluconatesolution4 g/100mLtopicalAplicare, Inc.1998-09-01Not applicableUs
Aplicare Antiseptic Chlorhexidine Gluconatesolution2 g/100gtopicalAplicare, Inc.1998-09-01Not applicableUs
Aplicare Antiseptic Chlorhexidine Gluconatesolution4 g/100mLtopicalAplicare, Inc.1998-09-01Not applicableUs
Aplicare Chlorhexidine Gluconate 2% Solutionsolution2 g/100mLtopicalAplicare, Inc.1998-09-01Not applicableUs
Avidene Surgical Scrubliquid2 %topicalMetrex Research1998-09-162001-07-23Canada
Bacti-stat Chgliquid2 %topicalEcolab Co1998-10-232000-07-31Canada
Bactigrasdressing.5 %topicalSmith & Nephew Inc1978-12-312011-11-07Canada
Bactoshieldsponge40 mg/mLtopicalSTERIS Corporation2003-03-27Not applicableUs
Bactoshield Chgsolution20 mg/mLtopicalSTERIS Corporation1999-10-04Not applicableUs
Bactoshield Chgsolution40 mg/mLtopicalSTERIS Corporation1999-10-04Not applicableUs
Bactoshield Chg 2%liquid2 %topicalSTERIS Corporation1998-08-182011-07-19Canada
Bactoshield Chg 4%liquid4 %topicalSTERIS Corporation1998-08-182011-07-19Canada
Baxedin Liq 0.05%liquid0.05 %topicalOmega Laboratories Ltd1989-12-31Not applicableCanada
Baxedin Liq 20%liquid20 %topicalOmega Laboratories Ltd1990-12-31Not applicableCanada
Baxedin Pre-OPsolution.5 %topicalOmega Laboratories Ltd1999-03-31Not applicableCanada
Bd E-Z Scrubsolution40 g/1000mLtopicalBecton Dickinson and Company2006-01-01Not applicableUs
Bd E-Z Scrubsolution20 mg/mLtopicalBecton Dickinson and Company2001-04-01Not applicableUs
Bd E-Z Scrub 107solution40 g/1000mLtopicalBecton Dickinson and Company2001-09-10Not applicableUs
Calgon Vestal 2% Chg Antimicrob.skin Cleans.liquid2 %topicalCalgon Vestal Laboratories Inc.1993-12-311997-04-25Canada
Calgon Vestal 4% Chg Antimicrob.skin Cleans.liquid4 %topicalCalgon Vestal Laboratories Inc.1993-12-311997-04-25Canada
Cardinal Healthliquid2 g/100mLtopicalCardinal Health2015-07-24Not applicableUs
Cardinal Health Antiseptic Skin Cleansersolution2 g/100mLtopicalCardinal Health2013-08-01Not applicableUs
Chlorhexidine 2% Antiseptic Hand Washsolution2 %topicalPartnar Animal Health Inc2008-03-03Not applicableCanada
Chlorhexidine 4% Antiseptic Hand Washsolution4 %topicalPartnar Animal Health Inc2008-03-03Not applicableCanada
Chlorhexidine Gluconatecloth500 mg/1topicalSage Products LLC2006-02-01Not applicableUs
Chlorhexidine Gluconate Solution 0.05%solution0.05 %topicalLaboratoire Atlas Inc1992-12-31Not applicableCanada
Chlorhexidine Gluconate Solution USP 20%solution20 %topicalGermiphene Corporation1994-12-31Not applicableCanada
Chlorhexidine Liq 0.05%liquid.05 %topicalBio Pharm Inc.1989-12-311996-09-09Canada
Chlorhexidine Solutionsolution2 %topicalPartnar Animal Health Inc2008-03-03Not applicableCanada
Chlorhexseptic-liq 0.5mg/mlliquid0.5 mgtopicalPharmascience Inc1995-12-31Not applicableCanada
Dermsafe Chlorhexidine Gluconate Hand Sanitizer Lotionlotion4 %topicalSkinvisible Pharmaceuticals IncNot applicableNot applicableCanada
Dermsafe Pclotion4 %topicalSkinvisible Pharmaceuticals Inc2012-02-23Not applicableCanada
Dexidin 2 Detergentliquid2 %topicalLaboratoire Atlas Inc1990-12-31Not applicableCanada
Dexidin 2 Solutionliquid2 %topicalLaboratoire Atlas Inc2000-03-28Not applicableCanada
Dexidin 20 Sol 20mgliquid20 %topicalLaboratoire Atlas Inc1989-12-31Not applicableCanada
Dexidin Liq 4%liquid4 %topicalLaboratoire Atlas Inc1990-12-31Not applicableCanada
Dyna-hex 2liquid2 g/100mLtopicalXttirum Laboratories, Inc.2014-01-01Not applicableUs
Dyna-hex 4liquid4 g/100mLtopicalXttrium Laboratories, Inc.2016-01-01Not applicableUs
Dyna-hex 4solution4 g/100mLtopicalWestern Medical Corporation1985-12-242015-12-29Us
Dyna-hex 75solution.75 mg/100mLtopicalBajaj Medical, Llc2014-09-30Not applicableUs
E-Z Scrub 747 4%liquid4 %topicalBecton Dickinson1991-12-31Not applicableCanada
E-Z Scrub Antimicrobial Foam Solution Containing 4% Chgliquid4.0 %topicalBecton Dickinson2000-10-192005-07-25Canada
Endure 400 Scrub-stat 4liquid4 %topicalEcolab Co1999-02-28Not applicableCanada
Endure 420 Cida-statliquid2 %topicalEcolab Co1999-12-15Not applicableCanada
First Aid Antiseptic Skin Cleanserliquid2 %topicalGermiphene Corporation2005-01-03Not applicableCanada
Foam Safeliquid4 g/100mLtopicalGermed Manufacturing Llc2013-01-01Not applicableUs
Germi Stat Gel 2%gel2 %topicalGermiphene Corporation1991-12-31Not applicableCanada
Germi Stat Gel 4%gel4 %topicalGermiphene Corporation1992-12-31Not applicableCanada
Germi-stat 2% Foaming Liquidliquid2 %topicalGermiphene Corporation2002-02-122012-07-18Canada
Henry Schein Antimicrobial Skin Cleansergel4 %topicalAbj Custom Packaging1993-12-31Not applicableCanada
Hexirex Antiseptic Skin Cleansersolution4 %topical (household)Imrex Inc.Not applicableNot applicableCanada
Hibiclenssolution213 g/1000mLtopicalA S Medication Solutions Llc1976-09-17Not applicableUs
Hibiclenssolution213 g/1000mLtopicalMolnlycke Health Care1976-09-17Not applicableUs
Hibiclenssolution213 g/1000mLtopicalPhysicians Total Care, Inc.2004-11-17Not applicableUs
Hibiclens Antiseptic/antimicrobial Skin Cleanserliquid4 %topicalRegent Medical Americas, Llc2002-09-242012-07-31Canada
Hibidilsolution0.05 %topicalRegent Medical Americas, Llc1993-12-312012-07-31Canada
Hibitane Skin Cleansersolution4 %topicalZoetis Canada Inc1972-12-31Not applicableCanada
Hibitane Skin Cleanser 2%liquid2 %topicalDurex Canada, Division Of Ssl Canada Inc.1993-12-312005-07-14Canada
Hibitane Skin Cleanser 4%liquid4 %topicalDurex Canada, Division Of Ssl Canada Inc.1994-12-312005-07-14Canada
Hibitane Skin Cleanser Liq 4%liquid4 %topicalWhitehall Robins Inc.1993-12-312005-07-28Canada
Hygenipak 2% Chg Skin Cleanserliquid2 %topicalDeb Canada2006-01-202011-06-17Canada
Hygienipak 2% Chg Foaming Skin Cleanserliquid2 %topicalDeb Canada2005-07-29Not applicableCanada
Hygienipak 4% Chg Foaming Skin Cleanserliquid4 %topicalDeb CanadaNot applicableNot applicableCanada
Hygienipak 4% Chg Skin Cleanserliquid4 %topicalDeb CanadaNot applicableNot applicableCanada
Laura Line Antibacterial Cream Soap 2%cream2 %topicalLaura Line, Division Of J.R. Phoenix Ltd.1997-09-272005-06-22Canada
Laura Line Chlorhexidine Antiseptic Soapliquid2 %topical3 M Canada Company2004-09-152014-03-26Canada
Loris 2% Chg Body Cleanser/nettoyant Pour Le Corpspad2 %topical (household)Lernapharm (Loris) Inc.Not applicableNot applicableCanada
Loris 2% Chg Solutionsolution2 %topical (household)Lernapharm (Loris) Inc.2014-07-10Not applicableCanada
Loris 2% Chg Wipe/serviettewipe2 %topical (household)Lernapharm (Loris) Inc.Not applicableNot applicableCanada
Oronine H Ointment 1%ointment1 %topicalClassical Remedia Ltd1994-12-312011-07-18Canada
Ostar Antimicrobial Hand Soap 2% - Liquidliquid2 %topicalUltravena Industries Limited1996-12-311997-03-13Canada
Perioselect Antimicrobial Sol 0.12%liquid.12 %topicalSultan Healthcare1992-12-311996-09-06Canada
Pre-scrub II Surgical Hand Scrubsolution1 mg/25mLtopicalBio Med Systems, Inc.1989-03-01Not applicableUs
Provon Antiseptic Lotion Soap With 2% Chglotion2 %topicalGOJO Industries, Inc.2002-09-09Not applicableCanada
Rougier Clean Dermsolution4 %topicalRougier Pharma Division Of Ratiopharm Inc2007-06-272015-10-01Canada
Rougier Vap-chlorhexidine Gluconate 2% W/Vsolution2 %topicalRougier Pharma Division Of Ratiopharm Inc2006-08-022015-10-01Canada
Rouhex G 20%liquid20 %topicalRougier Pharma Division Of Ratiopharm Inc1985-12-311999-09-27Canada
Rouhex G 4%liquid4 %topicalRougier Pharma Division Of Ratiopharm Inc1985-12-312000-09-07Canada
Rouhex G Liq 2%liquid2 %topicalRougier Pharma Division Of Ratiopharm Inc1985-12-311999-09-27Canada
Scrubsolution.75 mg/100mLtopicalBajaj Medical, Llc2014-09-30Not applicableUs
Scrub Caresolution4 mg/100mLtopicalProductos Urologos De Mexico, S.A. De C.V.1998-12-01Not applicableUs
Scrub Care Exidine -4 Chgliquid4 mg/100mLtopicalXttrium Laboratories, Inc.2012-11-01Not applicableUs
Scrub Care Exidine -4 Chgliquid4 mg/100mLtopicalXttrium Laboratories, Inc.2012-11-01Not applicableUs
Scrub Care Exidine-2 Chgsolution2 g/100mLtopicalXttrium Laboratories, Inc.2010-05-01Not applicableUs
Scrub Care Exidine-2 Chgsolution2 mg/100mLtopicalCVS Pharmacy, Inc.2015-12-01Not applicableUs
Scrub Care Exidine-2 Chgsolution2 g/100mLtopicalXttrium Laboratories, Inc.2010-05-01Not applicableUs
Scrub Care Surgical Scrub Brush/nail Cleaner With Exidine 4solution4 %topicalCardinal Health Medical Products And Services2005-07-212010-07-05Canada
Scrub Stat 4 Foam Liqliquid4 %topicalHuntington Laboratories, Ecolab Inc.1992-12-311999-08-10Canada
Scrub-statsolution20 mg/mLtopicalEcolab Inc.2010-12-03Not applicableUs
Scrub-statsolution20 mg/mLtopicalEcolab Inc.1986-07-22Not applicableUs
Scrub-statsolution40 mg/mLtopicalEcolab Inc.1986-07-22Not applicableUs
Scrub-statsolution40 mg/mLtopicalEcolab Inc.2011-03-01Not applicableUs
Skin Antisepsis, Oral Cleansing, Nasal AntisepsiskitSage Products, Inc.2012-02-06Not applicableUs
Skin Antisepsis, Oral Cleansing, Nasal AntisepsiskitSage Products, Inc.2012-02-06Not applicableUs
Skinvisible Chlorhexidine Formula Hand Sanitizer Lotionlotion2.25 %topicalSkinvisible Pharmaceuticals IncNot applicableNot applicableCanada
Soft Care 2% Chg Antimicrobial Skin Cleanserliquid2 %topicalDiversey Inc1999-03-012014-07-11Canada
Solunet C Brosse 4%liquid; sponge4 %topicalLes Entreprises Solumed Inc1995-12-312008-07-15Canada
Soluprep Antiseptic Skin Cleansersponge4 %topical (hospital/hc facilities)3 M Canada Company1996-12-31Not applicableCanada
Soluprep Antiseptic Skin Cleanser Preoperative Kitaerosol4 %topical3 M Canada Company1998-01-23Not applicableCanada
Soluprep AQsolution2 %topical3 M Canada Company2001-01-03Not applicableCanada
Soluprep AQ Applicatorsolution2 %topical (hospital/hc facilities)3 M Canada CompanyNot applicableNot applicableCanada
Soluprep AQ Spongesponge2 %topical (hospital/hc facilities)3 M Canada Company2014-02-20Not applicableCanada
Soluprep AQ Swabswab2 %topical (hospital/hc facilities)3 M Canada Company2015-09-10Not applicableCanada
Soluprep AQ Wipewipe2 %topical (hospital/hc facilities)3 M Canada Company2015-09-17Not applicableCanada
Soluprep Ld Spongesponge0.05 %topical (hospital/hc facilities)3 M Canada Company1997-09-03Not applicableCanada
Spectro Gram 2 Skin Cleanserliquid2 %topicalGlaxosmithkline Consumer Healthcare Inc.1989-12-312012-07-27Canada
Spray On Plastic Bandage Aerosolaerosol0.5 %topicalCmi Cosmetic Manufacturers Inc.Not applicableNot applicableCanada
Spray On Plastic Bandage Non-aerosolspray0.5 %topicalCmi Cosmetic Manufacturers Inc.Not applicableNot applicableCanada
Stanhexidine 20%liquid20 %topicalStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1988-12-311999-09-17Canada
Stanhexidine Red Tincture 0.5%liquid.5 %topicalStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1989-12-312002-07-31Canada
Stat Touch 2 Antimicrobial Skin Cleanserliquid2 %topicalColoplast Corp.1997-12-202001-06-22Canada
Steri-cleanspray2 %topical (household)Landco Import International IncNot applicableNot applicableCanada
Steri-stat Liq 2.0%liquid2 %topicalIngram And Bell Inc.1992-12-311999-08-05Canada
Steri-stat Liq 20%liquid20 %topicalIngram And Bell Inc.1992-12-311999-08-05Canada
Sterixin 0.05%solution0.05 %topicalLaboratoires Sterigen Inc2007-08-17Not applicableCanada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Antibacterial Protective Handlotion.07075 g/14.15gtopicalHANOVER PEN CORP dba HPC Global2013-02-01Not applicableUs
Antibacterial Protective Handlotion.0045 g/.9gtopicalHANOVER PEN CORP dba HPC Global2013-02-01Not applicableUs
Antiseptic Cleansing Wipesswab.0002 mg/mgtopicalFoshan Flying Medical Products Co., Ltd.2012-12-27Not applicableUs
Ezy-TMcloth2 g/100gtopicalJiangxi Sencen Hygienic Products Co., Ltd.2011-07-12Not applicableUs
Kleersightconcentrate2.36 mL/236mLirrigationBradley Fixtures Corporation2010-03-11Not applicableUs
Oris Chxrinse1.2 mg/mLdentalDentsply Professional1999-01-01Not applicableUs
Serdaensoap48 mg/3gtopicalBrowne Hansen Llc2013-06-01Not applicableUs
Serdaensoap24 mg/3gtopicalBrowne Hansen Llc2013-06-01Not applicableUs
International Brands
NameCompany
Cida-StatEcolab
CorsodylGlaxoSmithKline
Dyna-HexXttrium
ExidineXttrium
HexadolGreen Cross
HibiscrubAstraZeneca
HibisprayNot Available
HibitaneImperial Chemical Industries
MicrodermJohnson & Johnson
Oro-ClenseGermiphene
Periogard Oral RinseColgate
Pharmaseal Scrub CareCareFusion
Prevacare RJohnson & Johnson
RoterseptRoter
SterilonEmcure
TubulicidNot Available
Brand mixtures
NameLabellerIngredients
3m Avagard3 M Health Care
3m Soluprep Sponge3 M Canada Company
Avagard Chg3 M Canada Company
Baxedin 2% - 70%Omega Laboratories Ltd
Burn O Sol SprayProtector Canada Inc.
Chloraprep Liq 0.5%Medi Flex Inc.
Chloraprep One-stepCare Fusion 213 Llc
Chlorhexidine 0.5% LiqBio Pharm Inc.
Chlorhexidine and Isopropyl Alcohol Prep PadsProfessional Disposables International Inc.
Chlorhexidine and Isopropyl Alcohol SwabsticksProfessional Disposables International Inc.
Chlorhexidine-cetrimide Soltn ConcBio Pharm Inc.
Cida-stat FoamHuntington Laboratories, Ecolab Inc.
Cida-stat LiqHuntington Laboratories Canada Ltd.
Dexidin 0.5 SolutionLaboratoire Atlas Inc
Eyewash Station Additive ConcentrateNiagara Pharmaceuticals Inc.
Flamazine CSmith & Nephew Inc
Foam Care Chg Surgical Hand ScrubBallard Medical Products
Freeman Packing Alcohol WipeJiangxi Sencen Hygienic Products Co., Ltd.
Germi-stat 0.5% Antiseptic Prep GelGermiphene Corporation
Germi-stat Prep GelGermiphene Corporation
Hand WipesJiangmen Nowadays Daily Goods Co., Ltd.
Hexifoam-skin Disinfectant Aer 1%Soltec Research Pty Ltd.
HibistatMolnlycke Health Care US, LLC
Hibistat Germicidal Hand RinseRegent Medical Americas, Llc
Ic-gelGermiphene Corporation
InstillagelPendopharm Division Of De Pharmascience Inc
Loris - I.V.Lernapharm (Loris) Inc.
Microban MedicalNoveko Inc.
Oral Cleansing and Suctioning System, Q2Sage Products LLC
Oral Cleansing and Suctioning System, Q4Sage Products LLC
Physicianscare Eyewash Station Additive ConcentrateAcme United Corporation
Prevantics Maxi SwabstickProfessional Disposables International, Inc.
Prevantics SwabProfessional Disposables International, Inc.
PurmistMkr International Inc
Qcare Rx Oral Cleansing and Suctioning SystemSage Products LLC
Qcare Rx Oral Cleansing and Suctioning System, Q2Sage Products LLC
Qcare Rx Oral Cleansing and Suctioning System, Q4Sage Products LLC
Salvesept CrmProtector Canada Inc.
Scrub-stat IV 4%Huntington Laboratories Canada Ltd.
Soluprep3 M Canada Company
Soluprep Applicator3 M Canada Company
Soluprep Qd Solution3 M Canada Company
Soluprep Qd Swab3 M Canada Company
Soluprep Qd Wipe3 M Canada Company
Soluprep Swab3 M Canada Company
Soluprep Wipe3 M Canada Company
Spectro Tar Antiseptic ShampooSpectropharm Dermatology, A Division Of Draxis Health Inc.
Stanhexidine 2% With Isopropyl Alcohol 4%Omega Laboratories Ltd
Stanhexidine 4% With Isopropyl Alcohol 4%Omega Laboratories Ltd
Stanhexidine Aqueous 2% With 4% Isopropyl AlcoholOmega Laboratories Ltd
Steri-stat Liq 4.0%Ingram And Bell Inc.
Steri-stat Tincture (tinted) Antis Prep GelIngram And Bell Inc.
Sterigel Plus3 M Canada Company
Salts
Name/CASStructureProperties
Chlorhexidine acetate
ThumbNot applicableDBSALT001123
Chlorhexidine gluconate
Thumb
  • InChI Key: KUXUALPOSMRJSW-IFWQJVLJSA-N
  • Monoisotopic Mass: 700.261499162
  • Average Mass: 701.602
DBSALT000023
Chlorhexidine hydrochloride
ThumbNot applicableDBSALT001610
Categories
UNIIR4KO0DY52L
CAS number55-56-1
WeightAverage: 505.447
Monoisotopic: 504.203196424
Chemical FormulaC22H30Cl2N10
InChI KeyInChIKey=GHXZTYHSJHQHIJ-UHFFFAOYSA-N
InChI
InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)
IUPAC Name
N-(4-chlorophenyl)-1-3-(6-{N-[3-(4-chlorophenyl)carbamimidamidomethanimidoyl]amino}hexyl)carbamimidamidomethanimidamide
SMILES
ClC1=CC=C(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC2=CC=C(Cl)C=C2)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as chlorobenzenes. These are compounds containing one or more chlorine atoms attached to a benzene moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassHalobenzenes
Direct ParentChlorobenzenes
Alternative Parents
Substituents
  • Chlorobenzene
  • Biguanide
  • Aryl halide
  • Aryl chloride
  • Guanidine
  • Carboximidamide
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Imine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationFor reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in health-care personnel, general skin cleanser, and catheter site preparation and care.
PharmacodynamicsChlorhexidine, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action makes it highly unlikely for the development of bacterial resistance.
Mechanism of actionChlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
Related Articles
AbsorptionAbsorption of chlorhexidine from the gastrointestinal tract is very poor. Additionally, an in vivo study in 18 adult patients found no detectable plasma or urine chlorhexidine concentrations following insertion of four periodontal implants under clinical conditions.
Volume of distributionNot Available
Protein binding87%
MetabolismNot Available
Route of eliminationExcretion of chlorhexidine gluconate occurred primarily through the feces (~90%). Less than 1% of the chlorhexidine gluconate ingested by these subjects was excreted in the urine.
Half lifeNot Available
ClearanceNot Available
ToxicityLD50= 2g/kg (human, oral); LD50= 3 g/kg (rat, oral); LD50= 2.5 g/kg (mice, oral); LD50= 21 mg/kg (male rat, IV); LD50= 23 mg/kg (female rat, IV); LD50= 25 mg/kg (male mice, IV); LD50= 24 mg/kg (female mice, IV); LD50= 1g/kg (rat, subcutaneous); LD50= 637 mg/kg (male mice, subcutaneous); LD50= 632 mg/kg (female mice, subcutaneous)
Affected organisms
  • Bacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8984
Blood Brain Barrier+0.7872
Caco-2 permeable+0.5231
P-glycoprotein substrateSubstrate0.6016
P-glycoprotein inhibitor INon-inhibitor0.5733
P-glycoprotein inhibitor IIInhibitor0.9175
Renal organic cation transporterInhibitor0.7955
CYP450 2C9 substrateNon-substrate0.7033
CYP450 2D6 substrateNon-substrate0.6218
CYP450 3A4 substrateNon-substrate0.6532
CYP450 1A2 substrateInhibitor0.8025
CYP450 2C9 inhibitorNon-inhibitor0.6847
CYP450 2D6 inhibitorInhibitor0.927
CYP450 2C19 inhibitorNon-inhibitor0.5065
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.59
Ames testNon AMES toxic0.6532
CarcinogenicityNon-carcinogens0.857
BiodegradationNot ready biodegradable0.9896
Rat acute toxicity1.7711 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5579
hERG inhibition (predictor II)Non-inhibitor0.5661
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Xttrium laboratories inc
  • Sage products inc
  • Actavis mid atlantic llc
  • Hi tech pharmacal co inc
  • John o butler co
  • Novex pharma
  • Teva pharmaceuticals usa inc
  • Wockhardt eu operations (swiss) ag
  • 3m co
  • Colgate oral pharmaceuticals inc
  • Soapco inc
  • Ecolab inc
  • Regent medical americas llc
  • Johnson and johnson medical inc
  • Matrix medical corp
  • Kw griffen co
  • Becton dickinson and co
  • Kendall co
  • Becton dickinson surgical system
  • Molnlycke health care
  • Pharmaseal div baxter healthcare corp
  • Dexcel pharma technologies ltd
Packagers
Dosage forms
FormRouteStrength
Lotiontopical
Spongetopical (hospital/hc facilities)
Liquidoral.12 mg/mL
Lotiontopical.0045 g/.9g
Lotiontopical.07075 g/14.15g
Wipetopical2 %
Swabtopical.0002 mg/mg
Solutiontopical4 g/100mL
Solutiontopical2 g/100g
Liquidoral0.12 %
Lotiontopical (hospital/hc facilities)
Dressingtopical.5 %
Spongetopical40 mg/mL
Solutiontopical20 mg/mL
Solutiontopical40 mg/mL
Liquidtopical0.05 %
Solutiontopical.5 %
Solutiontopical40 g/1000mL
Solutiontopical.04 mg/mL
Spraytopical
Solutiontopical4 %
Padtopical
Swabtopical
Clothtopical500 mg/1
Rinseoral.12 mg/mL
Rinseoral1.2 mg/mL
Liquidbuccal1.2 [iU]/mL
Liquid; mouthwash/gargleoral0.12 %
Solutiontopical0.05 %
Solutiontopical20 %
Liquidtopical.05 %
Liquidtopical0.5 mg
Liquid; mouthwash/garglebuccal; oral0.12 %
Liquiddental.12 g/mL
Lotiontopical4 %
Liquidtopical2 %
Liquidtopical2 g/100mL
Liquidtopical4 g/100mL
Spongetopical4 %
Liquidtopical4.0 %
Liquidtopical4 %
Liquidophthalmic
Clothtopical2 g/100g
Creamtopical
Liquidtopical
Geltopical2 %
Geltopical
Mouthwash/garglebuccal0.12 %
Clothtopical
Geltopical4 %
Aerosoltopical
Solutiontopical (household)4 %
Solutiontopical213 g/1000mL
Concentrateirrigation2.36 mL/236mL
Creamtopical2 %
Padtopical (household)2 %
Solutiontopical (household)2 %
Wipetopical (household)2 %
Geltopical (household)
Kit
Rinsedental1.2 mg/mL
Liquidbuccal0.12 %
Ointmenttopical1 %
Liquid; mouthwash/garglebuccal0.12 %
Insert, extended releaseperiodontal2.5 mg/1
Liquidbuccal; oral0.12 %
Rinsebuccal1.2 mg/mL
Solutionbuccal0.12 %
Liquidtopical.12 %
Solutionophthalmic
Solutiontopical1 mg/25mL
Solutiontopical
Solution; kitdental10 %
Lotiontopical2 %
Solutiontopical.75 mg/100mL
Solutiontopical4 mg/100mL
Liquidtopical4 mg/100mL
Solutiontopical2 mg/100mL
Solutiontopical2 g/100mL
Soap bartopical
Lotiontopical2.0 %
Soaptopical24 mg/3g
Soaptopical48 mg/3g
Kit
Lotiontopical2.25 %
Liquid; spongetopical4 %
Solutiontopical (hospital/hc facilities)
Spongetopical (hospital/hc facilities)4 %
Aerosoltopical4 %
Solutiontopical2 %
Solutiontopical (hospital/hc facilities)2 %
Spongetopical (hospital/hc facilities)2 %
Swabtopical (hospital/hc facilities)2 %
Wipetopical (hospital/hc facilities)2 %
Spongetopical (hospital/hc facilities)0.05 %
Solution; spongetopical (hospital/hc facilities)
Swabtopical (hospital/hc facilities)
Wipetopical (hospital/hc facilities)
Shampootopical
Aerosoltopical0.5 %
Spraytopical0.5 %
Liquidtopical.5 %
Spraytopical (household)2 %
Liquidtopical20 %
Liquiddental.12 g/100mL
Prices
Unit descriptionCostUnit
Peridex 0.12% Solution 473ml Bottle23.99USD bottle
Periogard 0.12% Solution 473ml Bottle15.99USD bottle
Chlorhexidine Gluconate 0.12% Solution 473ml Bottle14.0USD bottle
Biopatch dressing4.21USD each
Hibistat towelette0.43USD each
Chlorhexidine gluc 20% soln0.16USD ml
Hibiclens 4% liquid0.04USD ml
Peridex 0.12% liquid0.04USD ml
Chlorhexidine 2% scrub0.03USD ml
Chlorhexidine 0.12% rinse0.02USD ml
Dynahex 4% liquid0.02USD ml
Dynahex 2% liquid0.01USD ml
Periogard 0.12% oral rinse0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5538353 No1995-08-252015-08-25Us
US5690958 No1996-09-302016-09-30Us
US5772346 No1997-04-222017-04-22Us
US5897031 No1996-06-212016-06-21Us
US6536975 No2000-11-102020-11-10Us
US6729786 No2003-03-142023-03-14Us
US6991394 No2004-01-312024-01-31Us
US7066916 No2004-02-172024-02-17Us
US7081246 No1996-08-032016-08-03Us
US7182536 No2003-12-302023-12-30Us
US7241065 No2003-03-142023-03-14Us
US7422388 No2007-04-252027-04-25Us
US7427574 No2006-04-252026-04-25Us
US7595021 No2003-05-122023-05-12Us
US7717889 No2005-02-272025-02-27Us
US7935093 No2007-10-022027-10-02Us
USD468424 No1997-01-072017-01-07Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point258-260Rose, F.L. and Swain, G.; US. Patent 2,684,924; July 27, 1954; assigned to Imperial Chemical Industries, Ltd.
water solubility800 mg/L (at 20 °C)MERCK INDEX (1996)
logP0.08HANSCH,C ET AL. (1995), ionized pH 5
pKa10.8 (at 25 °C)HANSCH,C & LEO,AJ (1985)
Predicted Properties
PropertyValueSource
Water Solubility0.0261 mg/mLALOGPS
logP2.71ALOGPS
logP4.51ChemAxon
logS-4.3ALOGPS
pKa (Strongest Basic)10.52ChemAxon
Physiological Charge4ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count10ChemAxon
Polar Surface Area167.58 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity181.71 m3·mol-1ChemAxon
Polarizability54.6 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Rose, F.L. and Swain, G.; US. Patent 2,684,924; July 27, 1954; assigned to Imperial Chemical Industries, Ltd.

US2684924
General References
  1. McBain AJ, Bartolo RG, Catrenich CE, Charbonneau D, Ledder RG, Gilbert P: Effects of a chlorhexidine gluconate-containing mouthwash on the vitality and antimicrobial susceptibility of in vitro oral bacterial ecosystems. Appl Environ Microbiol. 2003 Aug;69(8):4770-6. [PubMed:12902270 ]
External Links
ATC CodesS03AA04S02AA09D08AC02S01AX09R02AA05D08AC52A01AB03B05CA02D09AA12
AHFS Codes
  • 34:00.00
  • 52:04.92
  • 84:04.92
PDB EntriesNot Available
FDA labelDownload (56 KB)
MSDSDownload (73 KB)
Interactions
Drug InteractionsNo interactions found.
Food InteractionsNot Available

Targets

1. Bacterial outer membrane
Kind
Group
Organism
Pharmacological action
yes
Actions
incorporation into and destabilization
References
  1. Zorko M, Jerala R: Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics. J Antimicrob Chemother. 2008 Oct;62(4):730-7. doi: 10.1093/jac/dkn270. Epub 2008 Jul 16. [PubMed:18635521 ]
  2. Kuyyakanond T, Quesnel LB: The mechanism of action of chlorhexidine. FEMS Microbiol Lett. 1992 Dec 15;100(1-3):211-5. [PubMed:1335944 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Histamine n-methyltransferase activity
Specific Function:
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Gene Name:
HNMT
Uniprot ID:
P50135
Molecular Weight:
33294.765 Da
References
  1. Harle DG, Baldo BA: Structural features of potent inhibitors of rat kidney histamine N-methyltransferase. Biochem Pharmacol. 1988 Feb 1;37(3):385-8. [PubMed:3337739 ]
Kind
Protein
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pharmacological action
unknown
Actions
inhibitor
General Function:
Chloramphenicol o-acetyltransferase activity
Specific Function:
This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.
Gene Name:
cat
Uniprot ID:
P26841
Molecular Weight:
23524.385 Da
References
  1. Solov'eva NN, Belousova II, Tereshin IM: [Effect of biologically active substances on Escherichia coli chloramphenicol acetyltransferase activity]. Antibiotiki. 1979 Jun;24(6):436-40. [PubMed:378112 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on September 30, 2016 02:26