Showing BioInteractions for Bumetanide (DB00887)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 12 member 1 inhibitor
1	Solute carrier family 12 member 1 inhibitors	Chlorthalidone, Etacrynic acid, Furosemide, Hydroflumethiazide, Methyclothiazide, Piretanide, Quinethazone, Torasemide
2	Solute carrier family 12 member 1 inducers	Chlormerodrin
3	Solute carrier family 12 member 1 binders	Potassium chloride
4	Solute carrier family 12 member 1 substrates	Potassium bicarbonate, Potassium chloride, Potassium gluconate
5	Solute carrier family 12 member 1 ligands	Potassium

	Interacting Group	Interacting Drugs
	Bumetanide is a Cystic fibrosis transmembrane conductance regulator antagonist
1	Cystic fibrosis transmembrane conductance regulator antagonists	Crofelemer, Glyburide
2	Cystic fibrosis transmembrane conductance regulator potentiators	Ivacaftor
3	Cystic fibrosis transmembrane conductance regulator inhibitors	Colforsin, Dexibuprofen, Ibuprofen
4	Cystic fibrosis transmembrane conductance regulator modulators	Elexacaftor, Lumacaftor
5	Cystic fibrosis transmembrane conductance regulator cofactors	ATP
6	Cystic fibrosis transmembrane conductance regulator activators	Tezacaftor

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 12 member 2 inhibitor
1	Solute carrier family 12 member 2 inhibitors	Quinethazone, Torasemide
2	Solute carrier family 12 member 2 substrates	Potassium bicarbonate, Potassium chloride

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 12 member 4 inhibitor
1	Solute carrier family 12 member 4 substrates	Potassium chloride

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 12 member 5 inhibitor
1	Solute carrier family 12 member 5 substrates	Potassium chloride

	Interacting Group	Interacting Drugs
	Bumetanide is a Prostaglandin G/H synthase 2 inducer
1	Prostaglandin G/H synthase 2 inhibitors	Aceclofenac, Acetaminophen, Acetylsalicylic acid, Aminosalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Cannabidiol, Capsaicin, Carprofen, Celecoxib, Chlorphenesin, Choline magnesium trisalicylate, Cimicoxib, Cisplatin, Clodronic acid, Dexibuprofen, Dexketoprofen, Diclofenac, Diflunisal, Drospirenone, Droxicam, Etodolac, Etoricoxib, Fenoprofen, Fish oil, Flurbiprofen, Ginseng, Ibuprofen, Icosapent, Indomethacin, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Medical Cannabis, Mefenamic acid, Meloxicam, Mesalazine, Morniflumate, Nabiximols, Nabumetone, Naproxen, Nepafenac, Niflumic acid, Nimesulide, Oxaprozin, Parecoxib, Phenylbutazone, Piroxicam, Pomalidomide, Resveratrol, Rofecoxib, Salicylic acid, Salsalate, Seliciclib, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Triamcinolone, Trolamine salicylate, Valdecoxib
2	Prostaglandin G/H synthase 2 negative modulators	Lenalidomide
3	Prostaglandin G/H synthase 2 antagonists	Acemetacin, Alclofenac, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Thalidomide, Tolfenamic acid
4	Prostaglandin G/H synthase 2 substrates	Dapsone, Etoposide, Omega-3 fatty acids, Omega-6 fatty acids, Thalidomide
5	Prostaglandin G/H synthase 2 inducers	Aldesleukin, Bryostatin 1, Desmopressin, Drospirenone, Nonoxynol-9, Prasterone sulfate, Risedronic acid, Sapropterin, Sar9, Met (O2)11-Substance P, Semaxanib, Tafluprost

	Interacting Group	Interacting Drugs
	Bumetanide is a Sodium/bile acid cotransporter substrate
1	Sodium/bile acid cotransporter inhibitors	Bulevirtide, Cholic Acid, Conjugated estrogens, Cyclosporine, Ethinylestradiol, Probenecid, Progesterone, Remdesivir, Simeprevir, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid
2	Sodium/bile acid cotransporter substrates	Cholic Acid, Deoxycholic acid, Glycochenodeoxycholic Acid, Indomethacin, Liothyronine, Liotrix, Pitavastatin, Taurocholic acid, Thyroid, porcine, Ursodeoxycholic acid

	Interacting Group	Interacting Drugs
	Bumetanide is a Sodium/bile acid cotransporter inhibitor
1	Sodium/bile acid cotransporter inhibitors	Bulevirtide, Cholic Acid, Conjugated estrogens, Cyclosporine, Ethinylestradiol, Probenecid, Progesterone, Remdesivir, Simeprevir, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid
2	Sodium/bile acid cotransporter substrates	Cholic Acid, Deoxycholic acid, Glycochenodeoxycholic Acid, Indomethacin, Liothyronine, Liotrix, Pitavastatin, Taurocholic acid, Thyroid, porcine, Ursodeoxycholic acid

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 22 member 6 substrate
1	Solute carrier family 22 member 6 inhibitors	Acamprosate, Acetazolamide, Acetylsalicylic acid, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Indomethacin, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acamprosate, Acetylcysteine, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Indomethacin, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 22 member 6 inhibitor
1	Solute carrier family 22 member 6 inhibitors	Acamprosate, Acetazolamide, Acetylsalicylic acid, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Indomethacin, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acamprosate, Acetylcysteine, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Indomethacin, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 22 member 8 inhibitor
1	Solute carrier family 22 member 8 inhibitors	Acetylsalicylic acid, Acyclovir, Aminohippuric acid, Apalutamide, Artesunate, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Favipiravir, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Hydroflumethiazide, Ibuprofen, Indomethacin, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Novobiocin, Osilodrostat, Ouabain, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rimegepant, Rosuvastatin, Rucaparib, Salicylic acid, Tafamidis, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Valproic acid, Zidovudine
2	Solute carrier family 22 member 8 inducers	Methyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3	Solute carrier family 22 member 8 substrates	Acamprosate, Acyclovir, Allopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Betamethasone phosphate, Budesonide, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cortisone acetate, Cyclic adenosine monophosphate, Dexamethasone, Dexamethasone acetate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Empagliflozin, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Hydroflumethiazide, Leucovorin, Levocarnitine, Medrysone, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Oxytetracycline, Pemetrexed, Piperacillin, Polythiazide, Pravastatin, Prednisolone phosphate, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Valproic acid, Zidovudine

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 22 member 11 inhibitor
1	Solute carrier family 22 member 11 inhibitors	Aminohippuric acid, Aspartame, Benzylpenicillin, Caprylic acid, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Ceftriaxone, Cimetidine, Diclofenac, Dinoprostone, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Furosemide, Glutaric Acid, Ibuprofen, Indomethacin, Ketoprofen, Lesinurad, Novobiocin, Oxytetracycline, Phenylbutazone, Piroxicam, Probenecid, Salicylic acid, Tetracycline
2	Solute carrier family 22 member 11 substrates	Aminohippuric acid, Conjugated estrogens, Hydrochlorothiazide, Levocetirizine, Methotrexate, Oxytetracycline, Pravastatin, Relebactam

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier family 22 member 7 inhibitor
1	Solute carrier family 22 member 7 inhibitors	Cefalotin, Cefamandole, Cefoperazone, Cefotaxime, Cholic Acid, Cimetidine, Clarithromycin, Dinoprostone, Enalapril, Ganciclovir, Glyburide, Ketoprofen, Minocycline, Oxtriphylline, Oxytetracycline, Probenecid, Rifampicin, Testosterone, Tetracycline, Theophylline
2	Solute carrier family 22 member 7 substrates	Allopurinol, Aminohippuric acid, Cimetidine, Cyclic adenosine monophosphate, Dinoprostone, Docetaxel, Fluorouracil, Glutaric Acid, Indomethacin, Methotrexate, Oxytetracycline, Pravastatin, Salicylic acid, Tegafur-uracil, Valproic acid, Zalcitabine
3	Solute carrier family 22 member 7 inducers	Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate

	Interacting Group	Interacting Drugs
	Bumetanide is a Solute carrier organic anion transporter family member 1A2 substrate
1	Solute carrier organic anion transporter family member 1A2 substrates	Aminohippuric acid, Atorvastatin, Bilastine, Budesonide, Cholic Acid, Conjugated estrogens, Deoxycholic acid, Digoxin, Dinoprostone, Enalapril, Erythromycin, Fexofenadine, Glycochenodeoxycholic Acid, Indomethacin, Levofloxacin, Levothyroxine, Lifitegrast, Liothyronine, Liotrix, Medrysone, Methotrexate, Mirabegron, Ouabain, Prasterone, Pravastatin, Rocuronium, Taurocholic acid, Ursodeoxycholic acid
2	Solute carrier organic anion transporter family member 1A2 inhibitors	Aldosterone, Betamethasone phosphate, Cholic Acid, Conjugated estrogens, Cortisone acetate, Deoxycholic acid, Dexamethasone, Dexamethasone acetate, Digitoxin, Erythromycin, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Everolimus, Glyburide, Glycochenodeoxycholic Acid, Hydrocortisone, Hydroxychloroquine, Ibuprofen, Indinavir, Indomethacin, Ketoprofen, Lovastatin, Methyltestosterone, Naloxone, Naproxen, Nelfinavir, Ouabain, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Probenecid, Quinidine, Quinine, Rifampicin, Rifamycin, Ritonavir, Saquinavir, Simvastatin, Spironolactone, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tolbutamide, Ursodeoxycholic acid, Verapamil
3	Solute carrier organic anion transporter family member 1A2 inducers	Cholic Acid, Methyltestosterone, Sumatriptan, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid