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Identification
NameFamotidine
Accession NumberDB00927  (APRD00296)
TypeSmall Molecule
GroupsApproved
Description

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. [PubChem]

Structure
Thumb
Synonyms
(1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide
3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide
3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine
Famotidina
Famotidinum
N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide
Pepcid
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Bci Famotidinetablet40 mgoralBaker Cummins IncNot applicableNot applicableCanada
Bci Famotidinetablet20 mgoralBaker Cummins IncNot applicableNot applicableCanada
Famotidinepowder, for suspension40 mg/5mLoralPaddock Laboratories, Inc.2010-05-28Not applicableUs
Famotidine 10mgtablet10 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Famotidine Injectionsolution10 mgintravenousFresenius Kabi Canada LtdNot applicableNot applicableCanada
Famotidine Injectionsolution10 mgintravenousMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Famotidine Injectionsolution10 mgintravenousMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Famotidine Injectionsolution10 mgintravenousHospira Healthcare CorporationNot applicableNot applicableCanada
Famotidine IV Injectionsolution10 mgintravenousTeva Canada LimitedNot applicableNot applicableCanada
Famotidine IV Injectionsolution10 mgintravenousTeva Canada LimitedNot applicableNot applicableCanada
Famotidine Omega -(with Preservative,benzyl Alcohol)solution10 mgintravenousOmega Laboratories Ltd2003-10-31Not applicableCanada
Famotidine Omega -(without Preservative)solution10 mgintravenousOmega Laboratories Ltd2003-10-30Not applicableCanada
Famotidine Tabletstablet20 mgoralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Famotidine Tabletstablet40 mgoralSanis Health Inc2010-06-15Not applicableCanada
Famotidine Tabletstablet20 mgoralSanis Health Inc2010-06-15Not applicableCanada
Famotidine Tabletstablet40 mgoralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Famotidine-20tablet20 mgoralPro Doc Limitee2000-05-232010-07-13Canada
Famotidine-40tablet40 mgoralPro Doc Limitee2000-05-232010-07-13Canada
Mylan-famotidinetablet40 mgoralMylan Pharmaceuticals Ulc1995-12-31Not applicableCanada
Mylan-famotidinetablet20 mgoralMylan Pharmaceuticals Ulc1995-12-31Not applicableCanada
Ntp-famotidinetablet40 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-famotidinetablet20 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-famotidine Tab 20mgtablet20 mgoralNu Pharm Inc1994-12-312012-09-04Canada
Nu-famotidine Tab 40mgtablet40 mgoralNu Pharm Inc1994-12-312012-09-04Canada
Penta-famotidinetablet40 mgoralPentapharm Ltd.Not applicableNot applicableCanada
Penta-famotidinetablet20 mgoralPentapharm Ltd.Not applicableNot applicableCanada
Pepcidpowder, for suspension40 mg/5mLoralSalix Pharmaceuticals, Inc.1987-06-01Not applicableUs
Pepcidtablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.1986-10-15Not applicableUs
Pepcidtablet, film coated40 mg/1oralMarathon Pharmaceuticals, LLC1986-10-15Not applicableUs
Pepcidtablet, film coated20 mg/1oralMarathon Pharmaceuticals, LLC1986-10-15Not applicableUs
Pepcid I.V. 10mg/mlsolution10 mgintravenousMerck Canada Inc1987-12-312006-11-10Canada
Pepcid Tab 20mgtablet20 mgoralMerck Canada Inc1986-12-312013-07-15Canada
Pepcid Tab 40mgtablet40 mgoralMerck Canada Inc1986-12-312013-07-15Canada
Ratio-famotidine 20mgtablet20 mgoralRatiopharm Inc Division Of Teva Canada Limited2000-07-112006-08-04Canada
Ratio-famotidine 40mgtablet40 mgoralRatiopharm Inc Division Of Teva Canada Limited2000-07-112006-08-04Canada
Rhoxal-famotidinetablet40 mgoralRhoxalpharma Inc1999-08-032004-08-02Canada
Rhoxal-famotidinetablet20 mgoralRhoxalpharma Inc1999-08-032004-08-02Canada
Riva-famotidine 20 mgtablet20 mgoralLaboratoire Riva Inc2000-05-152003-07-28Canada
Riva-famotidine 40 mgtablet40 mgoralLaboratoire Riva Inc2000-05-152003-07-28Canada
Teva-famotidinetablet40 mgoralTeva Canada Limited1993-12-31Not applicableCanada
Teva-famotidinetablet20 mgoralTeva Canada Limited1993-12-31Not applicableCanada
Ulcidinetablet20 mgoralValeant Canada Lp Valeant Canada S.E.C.1998-03-242014-07-30Canada
Ulcidinetablet40 mgoralValeant Canada Lp Valeant Canada S.E.C.1998-03-242014-07-30Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-famotidine Injectablesolution10 mgintravenousApotex Inc2003-11-172013-08-02Canada
Apo-famotidine Injectablesolution10 mgintravenousApotex Inc2004-05-272013-08-02Canada
Apo-famotidine Tab 20mg USPtablet20 mgoralApotex Inc1993-12-31Not applicableCanada
Apo-famotidine Tab 40mg USPtablet40 mgoralApotex Inc1993-12-31Not applicableCanada
Famotidineinjection10 mg/mLintravenousWest Ward Pharmaceutical Corp.2001-04-16Not applicableUs
Famotidinetablet, film coated20 mg/1oralMylan Institutional Inc.2001-05-01Not applicableUs
Famotidinetablet, film coated40 mg/1oralWockhardt Limited2001-04-16Not applicableUs
Famotidinetablet10 mg/1oralbryant ranch prepack2010-02-18Not applicableUs
Famotidinetablet, film coated20 mg/1oralCarilion Materials Management2001-04-16Not applicableUs
Famotidineinjection, solution10 mg/mLintravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not applicableUs
Famotidinetablet, film coated20 mg/1oralNorthwind Pharmaceuticals2014-12-29Not applicableUs
Famotidinetablet20 mg/1oralGolden State Medical Supply, Inc.2001-04-16Not applicableUs
Famotidinetablet20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-07-01Not applicableUs
Famotidinepowder, for suspension40 mg/5mLoralLupin Pharmaceuticals, Inc2010-06-29Not applicableUs
Famotidinetablet20 mg/1oralAlembic Pharmaceuticals Limited2016-01-29Not applicableUs
Famotidinetablet, film coated40 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Famotidineinjection, solution20 mg/50mLintravenousBaxter Healthcare Corporation2001-05-10Not applicableUs
Famotidinetablet, film coated20 mg/1oralREMEDYREPACK INC.2013-03-05Not applicableUs
Famotidinetablet, film coated20 mg/1oralCardinal Health2009-06-10Not applicableUs
Famotidinetablet, film coated20 mg/1oralREMEDYREPACK INC.2014-09-30Not applicableUs
Famotidinetablet40 mg/1oralDispensing Solutions, Inc.2001-04-16Not applicableUs
Famotidinetablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc.2013-12-30Not applicableUs
Famotidinetablet40 mg/1oralREMEDYREPACK INC.2015-03-20Not applicableUs
Famotidinetablet20 mg/1oralAidarex Pharmaceuticals LLC2001-04-16Not applicableUs
Famotidineinjection10 mg/mLintravenousWest Ward Pharmaceutical Corp.2001-04-16Not applicableUs
Famotidinetablet40 mg/1oralUnit Dose Services2001-04-16Not applicableUs
Famotidinetablet, film coated20 mg/1oralWockhardt Limited2001-04-16Not applicableUs
Famotidineinjection, solution10 mg/mLintravenousFresenius Kabi USA, LLC2001-03-15Not applicableUs
Famotidinetablet20 mg/1oralAmerican Health Packaging2007-03-202016-01-31Us
Famotidinetablet40 mg/1oralAv Kare, Inc.2015-11-16Not applicableUs
Famotidinetablet, film coated40 mg/1oralKAISER FOUNDATION HOSPITALS2005-02-16Not applicableUs
Famotidinetablet40 mg/1oralMedsource Pharmaceuticals2001-04-16Not applicableUs
Famotidinetablet, film coated40 mg/1oralDr.Reddy's Laboratories Limited2001-04-16Not applicableUs
Famotidinetablet40 mg/1oralCarlsbad Technology, Inc2001-04-16Not applicableUs
Famotidinetablet, film coated40 mg/1oralAurobindo Pharma Limited2015-12-22Not applicableUs
Famotidinetablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc.2001-04-16Not applicableUs
Famotidinetablet20 mg/1oralUnit Dose Services2001-04-16Not applicableUs
Famotidinetablet40 mg/1oralNorth Star Rx Llc2009-07-01Not applicableUs
Famotidineinjection10 mg/mLintravenousWest Ward Pharmaceutical Corp.2001-04-16Not applicableUs
Famotidinetablet40 mg/1oralAv Pak2014-10-06Not applicableUs
Famotidinetablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2011-02-11Not applicableUs
Famotidineinjection, solution10 mg/mLintravenousAPP Pharmaceuticals, LLC2001-07-19Not applicableUs
Famotidinetablet40 mg/1oralBlue Point Laboratories2014-04-07Not applicableUs
Famotidinetablet20 mg/1oralAv Kare, Inc.2013-09-18Not applicableUs
Famotidinetablet, film coated40 mg/1oralIVAX Pharmaceuticals, Inc.2001-04-16Not applicableUs
Famotidinefor suspension40 mg/5mLoralGAVIS Pharmaceuticals, LLC2012-12-17Not applicableUs
Famotidinetablet, film coated20 mg/1oralDr.Reddy's Laboratories Limited2001-04-16Not applicableUs
Famotidinetablet20 mg/1oralCarlsbad Technology, Inc2001-04-16Not applicableUs
Famotidinetablet, film coated20 mg/1oralAurobindo Pharma Limited2015-12-22Not applicableUs
Famotidinetablet20 mg/1oralPreferred Pharmaceuticals Inc.2015-08-26Not applicableUs
Famotidinepowder, for solution40 mg/5mLoralHi Tech Pharmacal Co., Inc.2016-03-16Not applicableUs
Famotidinetablet20 mg/1oralNorth Star Rx Llc2009-07-01Not applicableUs
Famotidinetablet, film coated40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-30Not applicableUs
Famotidinetablet20 mg/1oralAv Pak2014-10-06Not applicableUs
Famotidinetablet, film coated20 mg/1oralCardinal Health2010-05-07Not applicableUs
Famotidinetablet20 mg/1oralDIRECT RX2014-01-01Not applicableUs
Famotidinetablet20 mg/1oralBlue Point Laboratories2014-04-07Not applicableUs
Famotidinefor suspension40 mg/5mLoralNovel Laboratories, Inc.2012-12-17Not applicableUs
Famotidinetablet, film coated20 mg/1oralIVAX Pharmaceuticals, Inc.2001-04-16Not applicableUs
Famotidinetablet, film coated40 mg/1oralPd Rx Pharmaceuticals, Inc.2001-04-16Not applicableUs
Famotidinetablet, film coated40 mg/1oralPhysicians Total Care, Inc.2002-11-15Not applicableUs
Famotidinetablet40 mg/1oralSt Marys Medical Park Pharmacy2013-07-10Not applicableUs
Famotidinetablet, film coated40 mg/1oralWockhardt USA LLC.2001-04-16Not applicableUs
Famotidinetablet40 mg/1oralLegacy Pharmaceutical Packaging, Llc2009-10-26Not applicableUs
Famotidinetablet40 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Famotidinetablet, film coated20 mg/1oralSTAT Rx USA LLC2001-04-16Not applicableUs
Famotidinetablet, film coated20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-30Not applicableUs
Famotidinetablet20 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-272016-01-29Us
Famotidinetablet20 mg/1oralCardinal Health2010-09-01Not applicableUs
Famotidinetablet, film coated20 mg/1oralREMEDYREPACK INC.2015-06-16Not applicableUs
Famotidineinjection10 mg/mLintravenousMylan Institutional LLC2008-06-26Not applicableUs
Famotidinetablet, film coated20 mg/1oralMc Kesson Contract Packaging2011-10-25Not applicableUs
Famotidinetablet, film coated20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-04-16Not applicableUs
Famotidineinjection, solution10 mg/mLintravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not applicableUs
Famotidinetablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2011-02-11Not applicableUs
Famotidinetablet, film coated20 mg/1oralPhysicians Total Care, Inc.2007-07-10Not applicableUs
Famotidinetablet20 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Famotidinetablet, film coated20 mg/1oralWockhardt USA LLC.2001-04-16Not applicableUs
Famotidinetablet20 mg/1oralLegacy Pharmaceutical Packaging, Llc2009-10-26Not applicableUs
Famotidinetablet20 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Famotidinetablet, film coated20 mg/1oralApotheca Inc.2001-04-16Not applicableUs
Famotidinetablet, film coated40 mg/1oralMylan Pharmaceuticals Inc.2001-04-16Not applicableUs
Famotidinetablet, film coated40 mg/1oralREMEDYREPACK INC.2013-03-05Not applicableUs
Famotidinetablet20 mg/1oralCardinal Health2010-10-13Not applicableUs
Famotidinetablet, film coated20 mg/1oralREMEDYREPACK INC.2015-03-26Not applicableUs
Famotidineinjection10 mg/mLintravenousMylan Institutional LLC2008-06-26Not applicableUs
Famotidinetablet, film coated20 mg/1oralAvera Mc Kennan Hospital2015-03-01Not applicableUs
Famotidinetablet, film coated40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-07-27Not applicableUs
Famotidinetablet, film coated20 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Famotidinetablet40 mg/1oralNorthwind Pharmaceuticals,LLC2014-08-25Not applicableUs
Famotidinetablet20 mg/1oralClinical Solutions Wholesale, Llc2001-04-16Not applicableUs
Famotidinetablet, film coated20 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-06-12Not applicableUs
Famotidinetablet, film coated40 mg/1oralCarilion Materials Management2001-04-16Not applicableUs
Famotidinetablet40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-04-16Not applicableUs
Famotidineinjection, solution10 mg/mLintravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not applicableUs
Famotidinetablet20 mg/1oralREMEDYREPACK INC.2013-07-01Not applicableUs
Famotidinetablet40 mg/1oralGolden State Medical Supply, Inc.2001-04-16Not applicableUs
Famotidinetablet20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2001-04-16Not applicableUs
Famotidinepowder, for suspension40 mg/5mLoralZydus Pharmaceuticals USA Inc2010-05-27Not applicableUs
Famotidinetablet40 mg/1oralAlembic Pharmaceuticals Limited2016-01-29Not applicableUs
Famotidinetablet20 mg/1oralBlenheim Pharmacal, Inc.2015-03-25Not applicableUs
Famotidinetablet, film coated20 mg/1oralMylan Pharmaceuticals Inc.2001-04-16Not applicableUs
Famotidinetablet, film coated40 mg/1oralREMEDYREPACK INC.2013-03-05Not applicableUs
Famotidinetablet20 mg/1oralCardinal Health2013-07-05Not applicableUs
Famotidinetablet20 mg/1oralREMEDYREPACK INC.2014-10-30Not applicableUs
Famotidineinjection10 mg/mLintravenousMylan Institutional LLC2008-06-26Not applicableUs
Famotidinetablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc.2012-07-27Not applicableUs
Famotidinetablet, film coated40 mg/1oralAidarex Pharmaceuticals LLC2001-04-16Not applicableUs
Pepcidtablet, film coated20 mg/1oralMarathon Pharmaceuticals, LLC2001-04-16Not applicableUs
Pepcidtablet, film coated20 mg/1oralMarathon Pharmaceuticals2014-05-27Not applicableUs
Pepcidtablet, film coated40 mg/1oralMarathon Pharmaceuticals, LLC2001-04-16Not applicableUs
Pepcidtablet, film coated40 mg/1oralMarathon Pharmaceuticals2014-05-27Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Acid Controllertablet20 mg/1oral7 Eleven2014-08-05Not applicableUs
Acid Controltablet10 mgoralVita Health Products Inc1998-10-27Not applicableCanada
Acid Controltablet10 mgoralApotex Inc2000-07-11Not applicableCanada
Acid Controltablet10 mgoralTeva Canada Limited1997-06-17Not applicableCanada
Acid Controltablet20 mgoralApotex Inc2014-04-28Not applicableCanada
Acid Controltablet10 mgoralPendopharm Division Of De Pharmascience Inc1997-09-082015-01-19Canada
Acid Control Original Strengthtablet10 mg/1oralMedicine Shoppe International Inc2009-10-19Not applicableUs
Acid Controllertablet20 mg/1oralCVS Pharmacy2006-09-28Not applicableUs
Acid Controllertablet20 mg/1oralShopko Stores Operating Co., LLC2013-07-17Not applicableUs
Acid Controllertablet10 mg/1oralH E B2015-10-23Not applicableUs
Acid Controllertablet20 mg/1oralWalgreen Company2006-09-26Not applicableUs
Acid Controller Maximum Strengthtablet20 mg/1oralSafeway2007-06-15Not applicableUs
Acid Controller Original Strengthtablet10 mg/1oralCVS Pharmacy2009-10-17Not applicableUs
Acid Controller Original Strengthtablet10 mg/1oralWalgreen Company2009-08-28Not applicableUs
Acid Controller Original Strengthtablet10 mg/1oralSafeway2009-12-13Not applicableUs
Acid Reducertablet10 mg/1oralL. Perrigo Company2014-07-23Not applicableUs
Acid Reducertablet10 mg/1oralPublix Super Markets Inc2009-11-23Not applicableUs
Acid Reducer Maximum Strengthtablet20 mg/1oralMeijer Distribution Inc2006-09-29Not applicableUs
Acid Reducer Maximum Strengthtablet20 mg/1oralRite Aid Corporation2006-09-29Not applicableUs
Acid Reducer Original Strengthtablet10 mg/1oralMeijer Distribution Inc2009-10-14Not applicableUs
Acid Reducer Original Strengthtablet10 mg/1oralHannaford Brothers Company2010-02-03Not applicableUs
Acid Reducer Original Strengthtablet10 mg/1oralWestern Family Foods Inc2009-10-23Not applicableUs
Acid Reducer Original Strengthtablet10 mg/1oralRite Aid Corporation2009-09-10Not applicableUs
Acid Reducer Original Strengthtablet, coated10 mg/1oralHy Vee Inc2001-09-24Not applicableUs
Acid Reducer Original Strengthtablet10 mg/1oralHy Vee Inc2009-10-19Not applicableUs
Acttablet10 mgoralNovopharm LimitedNot applicableNot applicableCanada
Apo-famotidinetablet10 mgoralApotex Inc1999-01-30Not applicableCanada
Berkley and Jensen Acid Controllertablet20 mg/1oralBJWC2006-11-08Not applicableUs
Berkley and Jensen Famotidinetablet20 mg/1oralBJWC2013-12-09Not applicableUs
Calmicid Ac Acid Reducertablet, film coated20 mg/1oralMelaleuca, Inc.2011-01-20Not applicableUs
Care One Acid Reducer Original Strengthtablet10 mg/1oralAmerican Sales Company2009-10-09Not applicableUs
Dg Health Heartburn Preventiontablet20 mg/1oralDolgencorp Inc2010-02-14Not applicableUs
Dg Health Heartburn Prevention Original Strengthtablet10 mg/1oralDolgencorp, LLC2010-03-10Not applicableUs
Equaline Heartburn Preventiontablet10 mg/1oralSupervalu Inc2009-09-18Not applicableUs
Equaline Heartburn Preventiontablet20 mg/1oralSupervalu Inc2014-12-05Not applicableUs
Equate Acid Controller Original Strengthtablet10 mg/1oralWal Mart Stores Inc2009-10-30Not applicableUs
Equate Famotidinetablet20 mg/1oralWal Mart Stores Inc2007-05-02Not applicableUs
Equate Famotidinetablet10 mg/1oralWal Mart Stores Inc2016-01-04Not applicableUs
Family Wellness Acid Reducertablet20 mg/1oralFamily Dollar Services Inc2013-08-30Not applicableUs
Family Wellness Acid Reducertablet10 mg/1oralFamily Dollar Services Inc2013-09-19Not applicableUs
Famotidinetablet10 mg/1oralDr.Reddys Laboratories Limited2006-09-30Not applicableUs
Famotidinetablet10 mg/1oralTeva Pharmaceuticals USA Inc2014-05-15Not applicableUs
Famotidinetablet, film coated20 mg/1oralKinray2012-02-15Not applicableUs
Famotidinetablet20 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Famotidinetablet20 mg/1oralWockhardt Limited2010-08-06Not applicableUs
Famotidinetablet, film coated10 mg/1oralChain Drug Marketing Association Inc.2010-06-25Not applicableUs
Famotidinetablet20 mg/1oralIpca Laboratories Limited2010-07-23Not applicableUs
Famotidinetablet, film coated20 mg/1oralWalgreen Company2013-11-07Not applicableUs
Famotidinetablet, film coated20 mg/1oralHEB2014-04-09Not applicableUs
Famotidinetablet, film coated20 mg/1oralChain Drug Marketing Association Inc.2010-07-23Not applicableUs
Famotidinetablet40 mg/1oralH.J. Harkins Company, Inc.2001-04-16Not applicableUs
Famotidinetablet10 mg/1oralIpca Laboratories Limited2010-06-25Not applicableUs
Famotidinetablet10 mg/1oralWockhardt USA LLC.2005-03-07Not applicableUs
Famotidinetablet10 mg/1oralIVAX Pharmaceuticals, Inc.2010-02-182016-01-31Us
Famotidinetablet, film coated20 mg/1oralAmerisource Bergen2010-07-23Not applicableUs
Famotidinetablet20 mg/1oralbryant ranch prepack2010-08-06Not applicableUs
Famotidinetablet20 mg/1oralWalmart Stores Inc.2011-11-04Not applicableUs
Famotidinetablet20 mg/1oralWockhardt USA LLC.2010-08-06Not applicableUs
Famotidinetablet40 mg/1oralbryant ranch prepack2001-04-16Not applicableUs
Famotidinetablet, film coated, extended release10 mg/1oralSPIRIT PHARMACEUTICALS,LLC2013-08-19Not applicableUs
Famotidinetablet, film coated10 mg/1oralSelect Brand2012-02-13Not applicableUs
Famotidinetablet, film coated20 mg/1oralValu Merchandisers Company2010-07-23Not applicableUs
Famotidinetablet20 mg/1oralDr.Reddys Laboratories Limited2006-09-30Not applicableUs
Famotidinetablet, film coated10 mg/1oralKinray2011-10-03Not applicableUs
Famotidinetablet, film coated20 mg/1oralShopko Stores Operating Co., LLC2010-07-23Not applicableUs
Famotidinetablet, film coated10 mg/1oralFred's Inc.2010-06-25Not applicableUs
Famotidinetablet10 mg/1oralWal Mart Stores Inc2012-07-05Not applicableUs
Famotidinetablet, film coated10 mg/1oralValu Merchandisers Company2010-06-25Not applicableUs
Famotidinetablet10 mg/1oralOUR FAMILY (Nash Finch Company)2013-10-15Not applicableUs
Famotidine - Acid Controllertablet, film coated10 mg/1oralWin Co Foods, Llc2012-05-01Not applicableUs
Famotidine - Acid Controllertablet, film coated20 mg/1oralWin Co Foods, Llc2012-05-01Not applicableUs
Famotidine - Acid Controllertablet, film coated20 mg/1oralOhm Laboratories Inc.2010-07-23Not applicableUs
Famotidine - Acid Controllertablet, film coated10 mg/1oralOhm Laboratories Inc.2010-06-25Not applicableUs
Famotidine Original Strengthtablet10 mg/1oralEQUATE (Walmart Stores, Inc.)2012-12-18Not applicableUs
Good Neighbor Pharmacy Acid Reducertablet10 mg/1oralAmerisource Bergen2009-10-07Not applicableUs
Good Neighbor Pharmacy Acid Reducertablet, coated10 mg/1oralAmerisource Bergen2001-06-05Not applicableUs
Good Neighbor Pharmacy Acid Reducer Maximum Strengthtablet20 mg/1oralAmerisource Bergen2006-10-24Not applicableUs
Good Sense Acid Reducertablet20 mg/1oralL Perrigo Company2007-03-16Not applicableUs
Good Sense Acid Reducertablet10 mg/1oralL Perrigo Company2009-10-23Not applicableUs
Harris Teeter Acid Reducertablet20 mg/1oralHarris Teeter, LLC2015-03-24Not applicableUs
Health Mart Famotidinetablet20 mg/1oralMc Kesson2012-03-20Not applicableUs
Health Mart Famotidinetablet10 mg/1oralMc Kesson2012-03-20Not applicableUs
Healthy Accents Famotidinetablet10 mg/1oralDZA Brands LLC2009-12-10Not applicableUs
Healthy Accents Famotidine Maximum Strengthtablet20 mg/1oralDZA Brands LLC2008-04-13Not applicableUs
Heartburn Preventiontablet20 mg/1oralKroger Company2015-02-05Not applicableUs
Heartburn Prevention Acid Reducertablet10 mg/1oralH E B2009-09-11Not applicableUs
Heartburn Prevention Original Strengthtablet10 mg/1oralKroger Company2009-10-09Not applicableUs
Heartburn Relieftablet10 mg/1oralSelect Corporation2014-03-14Not applicableUs
Heartburn Relief Original Strengthtablet10 mg/1oralMajor Pharmaceuticals2009-09-09Not applicableUs
Kirkland Signature Acid Controllertablet20 mg/1oralCostco Wholesale Company2007-05-24Not applicableUs
Leader Acid Reducer Maximum Strengthtablet20 mg/1oralCardinal Health2006-11-02Not applicableUs
Leader Acid Reducer Original Strengthtablet10 mg/1oralCardinal Health2009-10-14Not applicableUs
Maalox H2 Acid Controllertablet10 mgoralApotex Inc1997-11-302011-08-05Canada
Major Heartburn Relief Maximum Strengthtablet20 mg/1oralMajor Pharmaceuticals2006-09-29Not applicableUs
Maximum Strengthtablet20 mg/1oralPublix Super Markets Inc2007-12-03Not applicableUs
Maximum Strength Acid Reducertablet20 mg/1oralL.N.K. International, Inc.2013-08-012016-02-10Us
Maximum Strength Pepcid Actablet20 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2007-04-16Not applicableCanada
Members Mark Famotidinetablet20 mg/1oralSam's West Inc2006-09-28Not applicableUs
Pepcid Actablet10 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Pepcid Actablet, chewable20 mg/1oralMc Neil Consumer Pharmaceuticals Co.2008-02-01Not applicableUs
Pepcid Actablet10 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1996-07-23Not applicableCanada
Pepcid Ac (chewable Tab) - 10mgtablet10 mgoralMerck Canada Inc1997-04-282007-07-31Canada
Pepcid Ac Maximum Strengthtablet, film coated20 mg/1oralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2003-09-01Not applicableUs
Pepcid Ac Original Strengthtablet, film coated10 mg/1oralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division1995-10-01Not applicableUs
Peptic Guardtablet10 mgoralMylan Pharmaceuticals Ulc1997-12-12Not applicableCanada
Premier Value Famotidinetablet, film coated10 mg/1oralPremier Value2010-06-25Not applicableUs
Premier Value Famotidinetablet, film coated20 mg/1oralPremier Value2010-07-23Not applicableUs
Rx Act Heartburn Prevention Maximum Strengthtablet20 mg/1oralH E B2006-09-28Not applicableUs
Shoprite Acid Reducertablet20 mg/1oralWakefern Food Corporation2013-06-20Not applicableUs
Shoprite Acid Reducertablet10 mg/1oralWakefern Food Corporation2013-08-02Not applicableUs
Signature Care Acid Controllertablet10 mg/1oralSafeway2015-09-04Not applicableUs
Signature Care Acid Controller Maximum Strengthtablet20 mg/1oralSafeway2015-09-04Not applicableUs
Simply Right Famotidinetablet20 mg/1oralSam's West Inc2012-01-26Not applicableUs
Smart Sense Acid Reducertablet10 mg/1oralKmart Corporation2010-12-14Not applicableUs
Smart Sense Acid Reducer Maximum Strengthtablet20 mg/1oralKmart Corporation2010-12-21Not applicableUs
Smart Sense Famotidinetablet20 mg/1oralKmart Corporation2014-02-07Not applicableUs
Smart Sense Famotidinetablet10 mg/1oralKmart Corporation2014-02-18Not applicableUs
Sound Body Acid Reducertablet20 mg/1oralBig Lots Stores, Inc.2015-05-21Not applicableUs
Sunmark Acid Reducertablet10 mg/1oralMcKesson2009-09-10Not applicableUs
Sunmark Acid Reducertablet, coated10 mg/1oralMc Kesson2003-08-11Not applicableUs
Sunmark Acid Reducer Maximum Strengthtablet20 mg/1oralMc Kesson2007-06-18Not applicableUs
Topcare Acid Reducertablet20 mg/1oralTopco Associates LLC2006-09-28Not applicableUs
Topcare Acid Reducertablet10 mg/1oralTopco Associates LLC2009-09-11Not applicableUs
Up and Up Acid Reducer Original Strengthtablet10 mg/1oralTarget Corporation2009-10-13Not applicableUs
Up and Up Acid Reducer Original Strengthtablet, coated10 mg/1oralTarget Corporation2009-07-09Not applicableUs
Up and Up Famotidinetablet20 mg/1oralTarget Corporation2012-05-03Not applicableUs
Up and Up Famotidinetablet10 mg/1oralTarget Corporation2015-03-13Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Famotidineinjection, solution2 mg/mLintravenousCantrell Drug Company2014-06-11Not applicableUs
International Brands
NameCompany
AmfamoxNot Available
AntodineNot Available
ConfobosNot Available
CronolNot Available
DigervinNot Available
DispromilNot Available
DuovelNot Available
DuraterNot Available
FamocidNot Available
FamosanNot Available
FamotepNot Available
FamoxNot Available
FamoxalNot Available
FamtacNot Available
FamulcerNot Available
FanosinNot Available
FluxidNot Available
GasterNot Available
LecedilNot Available
MotiaxNot Available
Mylanta ARNot Available
NotidinNot Available
NulceranNot Available
PanalbaNot Available
Pepcid RPDNot Available
PepcidinNot Available
PepcidineNot Available
PepdineNot Available
PepfaminNot Available
QuamatelNot Available
RenapepsaNot Available
RubacinaNot Available
Sedanium-RNot Available
SupertidineNot Available
TairalNot Available
TipodexNot Available
UlfagelNot Available
UlfamidNot Available
UlgarineNot Available
VagostalNot Available
Brand mixtures
NameLabellerIngredients
Acid Controller CompleteSafeway
Acid Controller Complete Dual ActionWalgreen Company
Acid Reducer CompleteRite Aid Corporation
Acid Reducer Plus AntacidRite Aid Corporation
Berkley and Jensen Acid Controller CompleteBJWC
Care One Acid Reducer and Antacid Dual ActionAmerican Sales Company
Care One Acid Reducer Plus Antacid Dual ActionAmerican Sales Company
CompleteKroger Company
Complete Dual ActionHy Vee Inc
Dg Health Dual Action CompleteDolgencorp Inc
Dual ActionPublix Super Markets Inc
Dual Action CompleteKroger Company
DuexisHorizon Pharma Inc.
Duo FusionBoehringer Ingelheim Pharmaceuticals, Inc.
Equaline Complete Dual ActionSupervalu Inc
Equate Acid Reducer CompleteWal Mart Stores Inc
Family Wellness Acid Controller CompleteFamily Dollar Services Inc
Good Neighbor Pharmacy CompleteAmerisource Bergen
Good Neighbor Pharmacy Dual Action CompleteAmerisource Bergen
Good Sense CompleteL Perrigo Company
Good Sense Dual Action CompleteL Perrigo Company
Health Mart CompleteMc Kesson
Health Mart Dual Action CompleteMc Kesson
Healthy Accents Famotidine Calcium Carbonate Magnesium HydroxideDZA Brands LLC
Leader Acid Reducer CompleteCardinal Health
Pepcid CompleteJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Preferred Plus CompleteKinray
Shoprite CompleteWakefern Food Corporation
Shoprite Dual Action CompleteWakefern Food Corporation
Signature Care Acid Controller CompleteSafeway
Signature Care Acid Reducer CompleteSafeway
Simply Right Famotidine CompleteSam's West Inc
Smart Sense CompleteKmart Corporation
Smart Sense Dual Action CompleteKmart Corporation
Sunmark CompleteMc Kesson
Sunmark Dual Action CompleteMc Kesson
Topcare CompleteTopco Associates LLC
Topcare Complete Acid Reducer Plus AntacidTopco Associates LLC
Topcare Dual Action CompleteTopco Associates LLC
Up and Up Acid Controller Complete Dual ActionTarget Corporation
Up and Up Dual Action Acid Controller CompleteTarget Corporation
Up and Up Famotidine CompleteTarget Corporation
SaltsNot Available
Categories
UNII5QZO15J2Z8
CAS number76824-35-6
WeightAverage: 337.445
Monoisotopic: 337.044934829
Chemical FormulaC8H15N7O2S3
InChI KeyInChIKey=XUFQPHANEAPEMJ-UHFFFAOYSA-N
InChI
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
IUPAC Name
3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide
SMILES
NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzoles
Sub ClassThiazoles
Direct Parent2,4-disubstituted thiazoles
Alternative Parents
Substituents
  • 2,4-disubstituted 1,3-thiazole
  • Heteroaromatic compound
  • Organic sulfuric acid or derivatives
  • Guanidine
  • Azacycle
  • Dialkylthioether
  • Sulfenyl compound
  • Carboximidamide
  • Thioether
  • Amidine
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organonitrogen compound
  • Imine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
PharmacodynamicsFamotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Mechanism of actionFamotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.
Related Articles
AbsorptionThe bioavailability of oral doses is 40-45%.
Volume of distributionNot Available
Protein binding15-20%
Metabolism

Hepatic.

Route of eliminationRenal clearance is 250-450 mL/min, indicating some tubular excretion.
Half life2.5-3.5 hours
Clearance
  • renal cl=250-450 mL/min
ToxicityIntravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Famotidine Action PathwayDrug actionSMP00231
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9156
Blood Brain Barrier+0.9382
Caco-2 permeable-0.8957
P-glycoprotein substrateNon-substrate0.5839
P-glycoprotein inhibitor INon-inhibitor0.9044
P-glycoprotein inhibitor IINon-inhibitor0.8701
Renal organic cation transporterNon-inhibitor0.6802
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateNon-substrate0.7558
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9297
Ames testNon AMES toxic0.5827
CarcinogenicityNon-carcinogens0.9182
BiodegradationNot ready biodegradable0.9324
Rat acute toxicity1.9523 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8366
hERG inhibition (predictor II)Inhibitor0.6481
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Lupin ltd
  • Navinta llc
  • Salix pharmaceuticals inc
  • Akorn strides llc
  • Apotex inc richmond hill
  • Apothecon inc div bristol myers squibb
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Baxter healthcare corp
  • Bedford laboratories div ben venue laboratories inc
  • Hospira inc
  • Ben venue laboratories inc
  • Claris lifesciences ltd
  • Abbott laboratories
  • Baxter healthcare internati0nal specialty therapies div
  • Merck research laboratories div merck co inc
  • L perrigo co
  • Schwarz pharma inc
  • Actavis elizabeth llc
  • Alembic ltd
  • Apotex inc
  • Carlsbad technology inc
  • Dr reddys laboratories ltd
  • Genpharm inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Perrigo co
  • Ranbaxy laboratories inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Wockhardt ltd
  • Wockhardt americas inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral20 mg
Tabletoral40 mg
Tablet, coatedoral
For suspensionoral40 mg/5mL
Injectionintravenous10 mg/mL
Injection, solutionintravenous10 mg/mL
Injection, solutionintravenous2 mg/mL
Injection, solutionintravenous20 mg/50mL
Powder, for solutionoral40 mg/5mL
Powder, for suspensionoral40 mg/5mL
Tabletoral10 mg/1
Tabletoral40 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral20 mg/1
Tablet, film coatedoral40 mg/1
Tablet, film coated, extended releaseoral10 mg/1
Solutionintravenous10 mg
Tabletoral20 mg/1
Tablet, chewableoral
Tabletoral10 mg
Tablet, chewableoral20 mg/1
Tablet (chewable)oral
Tablet, coatedoral10 mg/1
Prices
Unit descriptionCostUnit
Pepcid 30 40 mg tablet Bottle125.5USD bottle
Pepcid 40 mg/5ml Suspension 50ml Bottle123.88USD bottle
Pepcid 30 20 mg tablet Bottle64.13USD bottle
Mylanta Double-Strength 400-400-40 mg/5ml Suspension 710ml Bottle10.15USD bottle
Mylanta 200-200-20 mg/5ml Suspension 710ml Bottle9.23USD bottle
Mylanta 200-200-20 mg/5ml Suspension 355ml Bottle7.99USD bottle
Mylanta Double-Strength 400-400-40 mg/5ml Suspension 355ml Bottle7.99USD bottle
Famotidine 40 mg tablet3.43USD tablet
Pepcid 40 mg tablet3.02USD tablet
Famotidine powder2.74USD g
Famotidine 20 mg tablet1.76USD tablet
Pepcid 20 mg tablet1.6USD tablet
Apo-Famotidine 40 mg Tablet1.11USD tablet
Mylan-Famotidine 40 mg Tablet1.11USD tablet
Novo-Famotidine 40 mg Tablet1.11USD tablet
Nu-Famotidine 40 mg Tablet1.11USD tablet
Pepcid ac 10 mg tablet0.72USD tablet
Famotidine 40 mg/4 ml vial0.71USD ml
Famotidine 500 mg/50 ml vial0.71USD ml
Apo-Famotidine 20 mg Tablet0.62USD tablet
Mylan-Famotidine 20 mg Tablet0.62USD tablet
Novo-Famotidine 20 mg Tablet0.62USD tablet
Nu-Famotidine 20 mg Tablet0.62USD tablet
Pepcid ac 20 mg tablet0.58USD tablet
Famotidine-ns 20 mg/10 ml syrg0.54USD ml
Pepcid ac 10 mg gelcap0.48USD capsule
Pepcid complete tablet chew0.4USD tablet
Famotidine 20 mg/2 ml vial0.36USD ml
Famotidine 10 mg/ml vial0.28USD ml
CVS Pharmacy acid controller 20 mg tablet0.24USD tablet
CVS Pharmacy acid controller tablet0.24USD tablet
Acid reducer 20 mg tablet0.22USD tablet
Acid controller 10 mg tablet0.21USD tablet
Mylanta gas 125 mg tablet chew0.16USD tablet
Acid reducer 10 mg tablet0.15USD tablet
Famotidine 10 mg tablet0.15USD tablet
Famotidine 20 mg piggyback0.13USD ml
Mylanta gelcap0.12USD capsule
Mylanta ultimate-strength tablet0.07USD tablet
Mylanta ultra chew tablet0.06USD tablet
Pv acid reducer 10 mg tablet0.05USD tablet
Mylanta liq0.02USD ml
Mylanta supreme antacid liq0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2052679 No1997-12-022011-08-21Canada
CA2178277 No2000-11-142016-06-05Canada
US5075114 No1993-05-232010-05-23Us
US5667794 Yes1995-11-022015-11-02Us
US5854267 Yes1996-06-292016-06-29Us
US5989588 Yes1998-03-302018-03-30Us
US6024981 No1998-04-092018-04-09Us
US6221392 No1998-04-092018-04-09Us
US6814978 Yes2002-02-262022-02-26Us
US8067033 No2006-07-182026-07-18Us
US8067451 No2006-07-182026-07-18Us
US8309127 No2006-07-182026-07-18Us
US8318202 No2006-07-182026-07-18Us
US8449910 No2006-07-182026-07-18Us
US8501228 No2006-07-182026-07-18Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point163.5 °CPhysProp
water solubility1000 mg/L (at 20 °C)MERCK INDEX (1996)
logP-0.64ISLAM,MS & NARURKAR,MM (1993)
Predicted Properties
PropertyValueSource
Water Solubility0.271 mg/mLALOGPS
logP-0.2ALOGPS
logP-2ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)9.29ChemAxon
pKa (Strongest Basic)8.38ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area175.83 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity80.46 m3·mol-1ChemAxon
Polarizability32.02 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-000i-0029000000-087ab7a1109f0568738dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-0udi-0900000000-d8a9ef8fc58c0c705232View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-000i-0900000000-e245f325e8c6f31a5fd0View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Montserrat Ballester-Rodes, Francisco E. Palomo-Nicolau, Antonio L. Palomo-Coli, “Famotidine polymorphic forms and their preparation process.” U.S. Patent US5021582, issued March, 1987.

US5021582
General ReferencesNot Available
External Links
ATC CodesA02BA03A02BA53
AHFS Codes
  • 56:28.12
PDB EntriesNot Available
FDA labelDownload (1.05 MB)
MSDSDownload (73.8 KB)
Interactions
Drug Interactions
Drug
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Famotidine.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Famotidine.
BupropionThe serum concentration of Famotidine can be increased when it is combined with Bupropion.
CefditorenThe serum concentration of Cefditoren can be decreased when it is combined with Famotidine.
CefpodoximeFamotidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
CefuroximeFamotidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
CitalopramFamotidine may increase the QTc-prolonging activities of Citalopram.
CysteamineThe therapeutic efficacy of Cysteamine can be decreased when used in combination with Famotidine.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Famotidine.
DasatinibFamotidine can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Famotidine.
DexmethylphenidateFamotidine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
DofetilideFamotidine may increase the QTc-prolonging activities of Dofetilide.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Famotidine.
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Famotidine.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Famotidine.
GoserelinFamotidine may increase the QTc-prolonging activities of Goserelin.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Famotidine.
Iron DextranFamotidine can cause a decrease in the absorption of Iron Dextran resulting in a reduced serum concentration and potentially a decrease in efficacy.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Famotidine.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Famotidine.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Famotidine.
LeuprolideFamotidine may increase the QTc-prolonging activities of Leuprolide.
MesalazineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Famotidine.
MethylphenidateFamotidine can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
MifepristoneMifepristone may increase the QTc-prolonging activities of Famotidine.
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Famotidine.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Famotidine.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Famotidine.
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Famotidine.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Famotidine.
RisedronateThe serum concentration of Risedronate can be increased when it is combined with Famotidine.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Famotidine.
VareniclineThe serum concentration of Varenicline can be increased when it is combined with Famotidine.
Food Interactions
  • Avoid alcohol.
  • Limit caffeine intake.
  • Take without regard to meals, food may slightly increase the product's bioavailability.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) si...
Gene Name:
HRH2
Uniprot ID:
P25021
Molecular Weight:
40097.65 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Fukuda M, Tanaka S, Suzuki S, Kusama K, Kaneko T, Sakashita H: Cimetidine induces apoptosis of human salivary gland tumor cells. Oncol Rep. 2007 Mar;17(3):673-8. [PubMed:17273750 ]
  3. Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. Epub 2006 May 24. [PubMed:16723495 ]
  4. Kesiova M, Alexandrova A, Yordanova N, Kirkova M, Todorov S: Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacol Rep. 2006 Mar-Apr;58(2):221-8. [PubMed:16702624 ]
  5. Lesclous P, Schramm F, Gallina S, Baroukh B, Guez D, Saffar JL: Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats. Exp Physiol. 2006 May;91(3):561-70. Epub 2006 Mar 2. [PubMed:16513821 ]
  6. Amagase K, Okabe S: On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion. J Pharmacol Sci. 2003 Jun;92(2):124-36. [PubMed:12832840 ]
  7. Weydert JA, Ball TM, Davis MF: Systematic review of treatments for recurrent abdominal pain. Pediatrics. 2003 Jan;111(1):e1-11. [PubMed:12509588 ]
  8. Miyata K, Kamato T, Nishida A, Honda K: Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol. 1991 Feb;55(2):211-22. [PubMed:2067140 ]
  9. Leurs R, Brozius MM, Smit MJ, Bast A, Timmerman H: Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine. Br J Pharmacol. 1991 Jan;102(1):179-85. [PubMed:1646056 ]
  10. Inan A, Sen M, Surgit O, Ergin M, Bozer M: Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo). 2009;64(6):567-70. [PubMed:19578661 ]
  11. Ojiako K, Shingala H, Schorr C, Gerber DR: Famotidine versus pantoprazole for preventing bleeding in the upper gastrointestinal tract of critically ill patients receiving mechanical ventilation. Am J Crit Care. 2008 Mar;17(2):142-7. [PubMed:18310651 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [PubMed:15496291 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [PubMed:15496291 ]
  2. Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. [PubMed:15100168 ]
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Drug created on June 13, 2005 07:24 / Updated on July 30, 2016 03:07