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Identification
NameFamotidine
Accession NumberDB00927  (APRD00296)
TypeSmall Molecule
GroupsApproved
Description

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
(1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamideNot AvailableNot Available
3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamideNot AvailableNot Available
3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidineNot AvailableNot Available
FamotidinaSpanishINN
FamotidinumLatinINN
N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamideNot AvailableNot Available
PepcidNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Famotidinepowder, for suspension40 mg/5mLoralPaddock Laboratories, Inc.2010-05-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcidtablet, film coated20 mgoralMarathon Pharmaceuticals, LLC1986-10-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcidtablet, film coated40 mgoralMarathon Pharmaceuticals, LLC1986-10-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcidtablet, film coated20 mgoralPd Rx Pharmaceuticals, Inc.1986-10-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcidpowder, for suspension40 mg/5mLoralSalix Pharmaceuticals, Inc.1987-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Famotidineinjection, solution10 mg/mLintravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection, solution10 mg/mLintravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection, solution10 mg/mLintravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralIVAX Pharmaceuticals, Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralIVAX Pharmaceuticals, Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralKAISER FOUNDATION HOSPITALS2005-02-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection, solution20 mg/50mLintravenousBaxter Healthcare Corporation2001-05-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralMylan Pharmaceuticals Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralMylan Pharmaceuticals Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection10 mg/mLintravenousWest Ward Pharmaceutical Corp.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection10 mg/mLintravenousWest Ward Pharmaceutical Corp.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection10 mg/mLintravenousWest Ward Pharmaceutical Corp.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralMajor Pharmaceuticals2009-06-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralMajor Pharmaceuticals2009-06-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralSTAT Rx USA LLC2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralNorth Star Rx Llc2009-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralNorth Star Rx Llc2009-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralAidarex Pharmaceuticals LLC2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralAidarex Pharmaceuticals LLC2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralLake Erie Medical DBA Quality Care Products LLC2012-07-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralLake Erie Medical DBA Quality Care Products LLC2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinefor suspension40 mg/5mLoralNovel Laboratories, Inc.2012-12-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralAv Kare, Inc.2013-09-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcidtablet, film coated20 mgoralMarathon Pharmaceuticals, LLC2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcidtablet, film coated40 mgoralMarathon Pharmaceuticals, LLC2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcidtablet, film coated20 mgoralMarathon Pharmaceuticals2014-05-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcidtablet, film coated40 mgoralMarathon Pharmaceuticals2014-05-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralPd Rx Pharmaceuticals, Inc.2011-02-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralPd Rx Pharmaceuticals, Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinefor suspension40 mg/5mLoralGAVIS Pharmaceuticals, LLC2012-12-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralREMEDYREPACK INC.2013-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralREMEDYREPACK INC.2013-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralREMEDYREPACK INC.2013-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralAv Pak2014-10-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralAv Pak2014-10-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralUnit Dose Services2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralUnit Dose Services2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralMylan Institutional Inc.2012-12-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralNorthwind Pharmaceuticals,LLC2014-08-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralNorthwind Pharmaceuticals2014-12-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralREMEDYREPACK INC.2013-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralPhysicians Total Care, Inc.2007-07-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralPhysicians Total Care, Inc.2002-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralDr.Reddy's Laboratories Limited2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralDr.Reddy's Laboratories Limited2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralCardinal Health2009-06-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralCardinal Health2013-07-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralCardinal Health2010-10-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralCardinal Health2010-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralCardinal Health2010-05-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralCardinal Health2010-05-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralPd Rx Pharmaceuticals, Inc.2011-02-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralWockhardt Limited2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralWockhardt Limited2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralGolden State Medical Supply, Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralGolden State Medical Supply, Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralSt Marys Medical Park Pharmacy2014-04-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralSt Marys Medical Park Pharmacy2013-07-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralCarlsbad Technology, Inc2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralCarlsbad Technology, Inc2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralREMEDYREPACK INC.2014-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralREMEDYREPACK INC.2014-10-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection, solution10 mg/mLintravenousAPP Pharmaceuticals, LLC2001-07-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection, solution10 mg/mLintravenousAPP Pharmaceuticals, LLC2001-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet10 mgoralbryant ranch prepack2010-02-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-06-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralWockhardt USA LLC.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralWockhardt USA LLC.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralDispensing Solutions, Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection10 mg/mLintravenousMylan Institutional LLC2008-06-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection10 mg/mLintravenousMylan Institutional LLC2008-06-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidineinjection10 mg/mLintravenousMylan Institutional LLC2008-06-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralBlue Point Laboratories2014-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralBlue Point Laboratories2014-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralAmerican Health Packaging2013-07-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralCarilion Materials Management2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralCarilion Materials Management2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinepowder, for suspension40 mg/5mLoralLupin Pharmaceuticals, Inc2010-06-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinepowder, for suspension40 mg/5mLoralZydus Pharmaceuticals USA Inc2010-05-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralLegacy Pharmaceutical Packaging2009-10-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralLegacy Pharmaceutical Packaging2009-10-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralPreferred Pharmaceuticals, Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralPreferred Pharmaceuticals, Inc.2013-12-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated40 mgoralPreferred Pharmaceuticals, Inc.2012-07-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralMc Kesson Contract Packaging2011-10-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Pepcid Actablet, chewable20 mgoralMc Neil Consumer Pharmaceuticals Co.2008-02-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcid Ac Maximum Strengthtablet, film coated20 mgoralMc Neil Consumer Pharmaceuticals Co.2003-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pepcid Ac Original Strengthtablet, film coated10 mgoralMc Neil Consumer Pharmaceuticals Co.1995-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet10 mgoralTeva Pharmaceuticals USA Inc2014-05-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Acid Reducertablet10 mgoralL Perrigo Company2009-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Acid Reducertablet20 mgoralL Perrigo Company2007-03-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducertablet10 mgoralL. Perrigo Company2014-07-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet10 mgoralIVAX Pharmaceuticals, Inc.2010-02-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralWalgreen Company2013-11-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Controller Original Strengthtablet10 mgoralWalgreen Company2009-08-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Controllertablet20 mgoralWalgreen Company2006-09-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Heartburn Relief original strengthtablet10 mgoralMajor Pharmaceuticals2009-09-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Major Heartburn Relief Maximum Strengthtablet20 mgoralMajor Pharmaceuticals2006-09-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
7 Select Acid Controllertablet20 mgoral7 Eleven2014-08-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducer original strengthtablet10 mgoralRite Aid Corporation2009-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducer maximum strengthtablet20 mgoralRite Aid Corporation2006-09-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated10 mgoralSelect Brand2012-02-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Controller original strengthtablet10 mgoralSafeway2009-12-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Controller Maximum Strengthtablet20 mgoralSafeway2007-06-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Acid Reducertablet, coated10 mgoralAmerisource Bergen2001-06-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Acid Reducer Maximum Strengthtablet20 mgoralAmerisource Bergen2006-10-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Heartburn Prevention original strengthtablet10 mgoralKroger Company2009-10-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Heartburn Preventiontablet20 mgoralKroger Company2015-02-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Acid Reducertablet10 mgoralTopco Associates LLC2009-09-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Acid Reducertablet20 mgoralTopco Associates LLC2006-09-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralShopko Stores Operating Co., LLC2010-07-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Controllertablet20 mgoralShopko Stores Operating Co., LLC2013-07-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Acid Reducer original strengthtablet10 mgoralCardinal Health2009-10-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Acid Reducer Maximum Strengthtablet20 mgoralCardinal Health2006-11-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralHEB2014-04-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Heartburn Prevention acid reducertablet10 mgoralH E B2009-09-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rx Act Heartburn Prevention maximum strengthtablet20 mgoralH E B2006-09-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Heartburn Preventiontablet20 mgoralSupervalu Inc2014-12-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Heartburn Preventiontablet10 mgoralSupervalu Inc2009-09-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Shoprite Acid Reducertablet10 mgoralWakefern Food Corporation2013-08-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Shoprite Acid Reducertablet20 mgoralWakefern Food Corporation2013-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducer original strengthtablet10 mgoralMeijer Distribution Inc2009-10-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducer Maximum Strengthtablet20 mgoralMeijer Distribution Inc2006-09-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducer original strengthtablet10 mgoralHannaford Brothers Company2010-02-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Care One Acid Reducer original strengthtablet10 mgoralAmerican Sales Company2009-10-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducer original strengthtablet10 mgoralHy Vee Inc2009-10-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducer Original Strengthtablet, coated10 mgoralHy Vee Inc2001-09-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralAmerisource Bergen2010-07-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Acid Reducertablet10 mgoralAmerisource Bergen2009-10-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralSafecor Health, LLC2014-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet10 mgoralWal Mart Stores Inc2012-07-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidine original strengthtablet10 mgoralEQUATE (Walmart Stores, Inc.)2012-12-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Acid Controller Original Strengthtablet10 mgoralWal Mart Stores Inc2009-10-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralWalmart Stores Inc.2011-11-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Famotidinetablet20 mgoralWal Mart Stores Inc2007-05-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Acid Reducertablet10 mgoralMcKesson2009-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Acid Reducertablet, coated10 mgoralMc Kesson2003-08-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Acid Reducer maximum strengthtablet20 mgoralMc Kesson2007-06-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Control original strengthtablet10 mgoralMedicine Shoppe International Inc2009-10-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Acid Reducertablet10 mgoralKmart Corporation2010-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Acid Reducer Maximum Strengthtablet20 mgoralKmart Corporation2010-12-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Famotidinetablet10 mgoralKmart Corporation2014-02-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Famotidinetablet20 mgoralKmart Corporation2014-02-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Maximum Strength Acid Reducertablet20 mgoralL.N.K. International, Inc.2013-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidine - Acid Controllertablet, film coated10 mgoralOhm Laboratories Inc.2010-06-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidine - Acid Controllertablet, film coated20 mgoralOhm Laboratories Inc.2010-07-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Heartburn Relieftablet10 mgoralSelect Corporation2014-03-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralH.J. Harkins Company, Inc.2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet10 mgoralDr.Reddys Laboratories Limited2006-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralDr.Reddys Laboratories Limited2006-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducer original strengthtablet10 mgoralWestern Family Foods Inc2009-10-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated10 mgoralFred's Inc.2010-06-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthy Accents Famotidinetablet10 mgoralDZA Brands LLC2009-12-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthy Accents Famotidine maximum strengthtablet20 mgoralDZA Brands LLC2008-04-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Family Wellness Acid Reducertablet10 mgoralFamily Dollar Services Inc2013-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Family Wellness Acid Reducertablet20 mgoralFamily Dollar Services Inc2013-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralWockhardt Limited2010-08-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dg Health Heartburn Prevention original strengthtablet10 mgoralDolgencorp, LLC2010-03-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dg Health Heartburn Preventiontablet20 mgoralDolgencorp Inc2010-02-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Reducertablet10 mgoralPublix Super Markets Inc2009-11-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Maximum Strengthtablet20 mgoralPublix Super Markets Inc2007-12-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet10 mgoralIpca Laboratories Limited2010-06-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralIpca Laboratories Limited2010-07-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Controller original strengthtablet10 mgoralCVS Pharmacy2009-10-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Acid Controllertablet20 mgoralCVS Pharmacy2006-09-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated10 mgoralKinray2011-10-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralKinray2012-02-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Famotidinetablet10 mgoralMc Kesson2012-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Famotidinetablet20 mgoralMc Kesson2012-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet40 mgoralbryant ranch prepack2001-04-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralbryant ranch prepack2010-08-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralChain Drug Marketing Association Inc.2010-07-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated10 mgoralChain Drug Marketing Association Inc.2010-06-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated10 mgoralValu Merchandisers Company2010-06-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated20 mgoralValu Merchandisers Company2010-07-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kirkland Signature Acid Controllertablet20 mgoralCostco Wholesale Company2007-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet20 mgoralWockhardt USA LLC.2010-08-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet10 mgoralWockhardt USA LLC.2005-03-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidine - Acid Controllertablet, film coated20 mgoralWin Co Foods, Llc2012-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidine - Acid Controllertablet, film coated10 mgoralWin Co Foods, Llc2012-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Premier Value Famotidinetablet, film coated20 mgoralPremier Value2010-07-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Premier Value Famotidinetablet, film coated10 mgoralPremier Value2010-06-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Famotidinetablet20 mgoralSam's West Inc2006-09-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Famotidinetablet20 mgoralSam's West Inc2012-01-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet, film coated, extended release10 mgoralSPIRIT PHARMACEUTICALS,LLC2013-08-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Famotidinetablet10 mgoralOUR FAMILY (Nash Finch Company)2013-10-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
International Brands
NameCompany
AmfamoxNot Available
AntodineNot Available
ConfobosNot Available
CronolNot Available
DigervinNot Available
DispromilNot Available
DuovelNot Available
DuraterNot Available
FamocidNot Available
FamosanNot Available
FamotepNot Available
FamoxNot Available
FamoxalNot Available
FamtacNot Available
FamulcerNot Available
FanosinNot Available
FluxidNot Available
GasterNot Available
LecedilNot Available
MotiaxNot Available
Mylanta ARNot Available
NotidinNot Available
NulceranNot Available
PanalbaNot Available
Pepcid RPDNot Available
PepcidinNot Available
PepcidineNot Available
PepdineNot Available
PepfaminNot Available
QuamatelNot Available
RenapepsaNot Available
RubacinaNot Available
Sedanium-RNot Available
SupertidineNot Available
TairalNot Available
TipodexNot Available
UlfagelNot Available
UlfamidNot Available
UlgarineNot Available
VagostalNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
CAS number76824-35-6
WeightAverage: 337.445
Monoisotopic: 337.044934829
Chemical FormulaC8H15N7O2S3
InChI KeyXUFQPHANEAPEMJ-UHFFFAOYSA-N
InChI
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
IUPAC Name
3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide
SMILES
NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzoles
Sub ClassThiazoles
Direct Parent2,4-disubstituted thiazoles
Alternative Parents
Substituents
  • 2,4-disubstituted 1,3-thiazole
  • Heteroaromatic compound
  • Organic sulfuric acid or derivatives
  • Guanidine
  • Azacycle
  • Dialkylthioether
  • Sulfenyl compound
  • Carboximidamide
  • Thioether
  • Amidine
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organonitrogen compound
  • Imine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
PharmacodynamicsFamotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Mechanism of actionFamotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.
AbsorptionThe bioavailability of oral doses is 40-45%.
Volume of distributionNot Available
Protein binding15-20%
Metabolism

Hepatic.

Route of eliminationRenal clearance is 250-450 mL/min, indicating some tubular excretion.
Half life2.5-3.5 hours
Clearance
  • renal cl=250-450 mL/min
ToxicityIntravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9156
Blood Brain Barrier+0.9382
Caco-2 permeable-0.8957
P-glycoprotein substrateNon-substrate0.5839
P-glycoprotein inhibitor INon-inhibitor0.9044
P-glycoprotein inhibitor IINon-inhibitor0.8701
Renal organic cation transporterNon-inhibitor0.6802
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateNon-substrate0.7558
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 substrateNon-inhibitor0.9071
CYP450 2D6 substrateNon-inhibitor0.9231
CYP450 2C19 substrateNon-inhibitor0.9025
CYP450 3A4 substrateNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9297
Ames testNon AMES toxic0.5827
CarcinogenicityNon-carcinogens0.9182
BiodegradationNot ready biodegradable0.9324
Rat acute toxicity1.9523 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8366
hERG inhibition (predictor II)Inhibitor0.6481
Pharmacoeconomics
Manufacturers
  • Lupin ltd
  • Navinta llc
  • Salix pharmaceuticals inc
  • Akorn strides llc
  • Apotex inc richmond hill
  • Apothecon inc div bristol myers squibb
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Baxter healthcare corp
  • Bedford laboratories div ben venue laboratories inc
  • Hospira inc
  • Ben venue laboratories inc
  • Claris lifesciences ltd
  • Abbott laboratories
  • Baxter healthcare internati0nal specialty therapies div
  • Merck research laboratories div merck co inc
  • L perrigo co
  • Schwarz pharma inc
  • Actavis elizabeth llc
  • Alembic ltd
  • Apotex inc
  • Carlsbad technology inc
  • Dr reddys laboratories ltd
  • Genpharm inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Perrigo co
  • Ranbaxy laboratories inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Wockhardt ltd
  • Wockhardt americas inc
Packagers
Dosage forms
FormRouteStrength
For suspensionoral40 mg/5mL
Injectionintravenous10 mg/mL
Injection, solutionintravenous10 mg/mL
Injection, solutionintravenous20 mg/50mL
Powder, for suspensionoral40 mg/5mL
Tabletoral10 mg
Tabletoral20 mg
Tabletoral40 mg
Tablet, chewableoral20 mg
Tablet, coatedoral10 mg
Tablet, film coatedoral10 mg
Tablet, film coatedoral20 mg
Tablet, film coatedoral40 mg
Tablet, film coated, extended releaseoral10 mg
Prices
Unit descriptionCostUnit
Pepcid 30 40 mg tablet Bottle125.5USD bottle
Pepcid 40 mg/5ml Suspension 50ml Bottle123.88USD bottle
Pepcid 30 20 mg tablet Bottle64.13USD bottle
Mylanta Double-Strength 400-400-40 mg/5ml Suspension 710ml Bottle10.15USD bottle
Mylanta 200-200-20 mg/5ml Suspension 710ml Bottle9.23USD bottle
Mylanta 200-200-20 mg/5ml Suspension 355ml Bottle7.99USD bottle
Mylanta Double-Strength 400-400-40 mg/5ml Suspension 355ml Bottle7.99USD bottle
Famotidine 40 mg tablet3.43USD tablet
Pepcid 40 mg tablet3.02USD tablet
Famotidine powder2.74USD g
Famotidine 20 mg tablet1.76USD tablet
Pepcid 20 mg tablet1.6USD tablet
Apo-Famotidine 40 mg Tablet1.11USD tablet
Mylan-Famotidine 40 mg Tablet1.11USD tablet
Novo-Famotidine 40 mg Tablet1.11USD tablet
Nu-Famotidine 40 mg Tablet1.11USD tablet
Pepcid ac 10 mg tablet0.72USD tablet
Famotidine 40 mg/4 ml vial0.71USD ml
Famotidine 500 mg/50 ml vial0.71USD ml
Apo-Famotidine 20 mg Tablet0.62USD tablet
Mylan-Famotidine 20 mg Tablet0.62USD tablet
Novo-Famotidine 20 mg Tablet0.62USD tablet
Nu-Famotidine 20 mg Tablet0.62USD tablet
Pepcid ac 20 mg tablet0.58USD tablet
Famotidine-ns 20 mg/10 ml syrg0.54USD ml
Pepcid ac 10 mg gelcap0.48USD capsule
Pepcid complete tablet chew0.4USD tablet
Famotidine 20 mg/2 ml vial0.36USD ml
Famotidine 10 mg/ml vial0.28USD ml
CVS Pharmacy acid controller 20 mg tablet0.24USD tablet
CVS Pharmacy acid controller tablet0.24USD tablet
Acid reducer 20 mg tablet0.22USD tablet
Acid controller 10 mg tablet0.21USD tablet
Mylanta gas 125 mg tablet chew0.16USD tablet
Acid reducer 10 mg tablet0.15USD tablet
Famotidine 10 mg tablet0.15USD tablet
Famotidine 20 mg piggyback0.13USD ml
Mylanta gelcap0.12USD capsule
Mylanta ultimate-strength tablet0.07USD tablet
Mylanta ultra chew tablet0.06USD tablet
Pv acid reducer 10 mg tablet0.05USD tablet
Mylanta liq0.02USD ml
Mylanta supreme antacid liq0.02USD ml
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Patents
CountryPatent NumberApprovedExpires (estimated)
Canada20526791997-12-022011-08-21
Canada21782772000-11-142016-06-05
United States50751141993-05-232010-05-23
United States68149782002-02-262022-02-26
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point163.5 °CPhysProp
water solubility1000 mg/L (at 20 °C)MERCK INDEX (1996)
logP-0.64ISLAM,MS & NARURKAR,MM (1993)
Predicted Properties
PropertyValueSource
Water Solubility0.271 mg/mLALOGPS
logP-0.2ALOGPS
logP-2ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)9.29ChemAxon
pKa (Strongest Basic)8.38ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area175.83 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity80.46 m3·mol-1ChemAxon
Polarizability32.02 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraMS/MS1D NMR2D NMR
References
Synthesis Reference

Montserrat Ballester-Rodes, Francisco E. Palomo-Nicolau, Antonio L. Palomo-Coli, “Famotidine polymorphic forms and their preparation process.” U.S. Patent US5021582, issued March, 1987.

US5021582
General ReferenceNot Available
External Links
ATC CodesA02BA03
AHFS Codes
  • 56:28.12
PDB EntriesNot Available
FDA labelDownload (1.05 MB)
MSDSDownload (73.8 KB)
Interactions
Drug Interactions
Drug
AtazanavirH2-Antagonists may decrease the serum concentration of Atazanavir.
BosutinibH2-Antagonists may decrease the serum concentration of Bosutinib.
BupropionMay increase the serum concentration of OCT2 Substrates.
CefditorenH2-Antagonists may decrease the serum concentration of Cefditoren.
CefpodoximeH2-Antagonists may decrease the absorption of Cefpodoxime. Separate oral doses by at least 2 hours.
CefuroximeH2-Antagonists may decrease the absorption of Cefuroxime. Separate oral doses by at least 2 hours.
DabrafenibH2-Antagonists may decrease the serum concentration of Dabrafenib.
DasatinibH2-Antagonists may decrease the absorption of Dasatinib.
DelavirdineH2-Antagonists may decrease the serum concentration of Delavirdine.
DexmethylphenidateH2-Antagonists may increase the absorption of Dexmethylphenidate. Specifically, H2-antagonists may interfere with the normal release of drug from the extended-release capsules (Focalin XR brand), which could result in both increased absorption (early) and decreased delayed absorption.
ErlotinibH2-Antagonists may decrease the serum concentration of Erlotinib.
FosamprenavirH2-Antagonists may decrease the serum concentration of Fosamprenavir. Cimetidine may also inhibit the metabolism of the active metabolite amprenavir, making its effects on fosamprenavir/amprenavir concentrations difficult to predict.
GefitinibH2-Antagonists may decrease the serum concentration of Gefitinib.
IndinavirH2-Antagonists may decrease the serum concentration of Indinavir.
ItraconazoleH2-Antagonists may decrease the serum concentration of Itraconazole.
LedipasvirH2-Antagonists may decrease the serum concentration of Ledipasvir.
MethylphenidateH2-Antagonists may increase the absorption of Methylphenidate. Specifically, H2-antagonists may interfere with the normal release of drug from the extended-release capsules (Ritalin LA brand), which could result in both increased absorption (early) and decreased delayed absorption.
MifepristoneMay enhance the QTc-prolonging effect of QTc-Prolonging Agents (Indeterminate Risk and Risk Modifying).
NelfinavirH2-Antagonists may decrease the serum concentration of Nelfinavir. Concentrations of the active M8 metabolite may also be reduced.
NilotinibH2-Antagonists may decrease the serum concentration of Nilotinib.
PazopanibH2-Antagonists may decrease the serum concentration of PAZOPanib.
PosaconazoleH2-Antagonists may decrease the serum concentration of Posaconazole.
RilpivirineH2-Antagonists may decrease the serum concentration of Rilpivirine.
RisedronateH2-Antagonists may increase the serum concentration of Risedronate. This applies specifically to delayed-release risedronate.
SaquinavirH2-Antagonists may increase the serum concentration of Saquinavir.
VareniclineH2-Antagonists may increase the serum concentration of Varenicline.
VismodegibH2-Antagonists may decrease the serum concentration of Vismodegib.
Food Interactions
  • Avoid alcohol.
  • Limit caffeine intake.
  • Take without regard to meals, food may slightly increase the product's bioavailability.

Targets

1. Histamine H2 receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Histamine H2 receptor P25021 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Fukuda M, Tanaka S, Suzuki S, Kusama K, Kaneko T, Sakashita H: Cimetidine induces apoptosis of human salivary gland tumor cells. Oncol Rep. 2007 Mar;17(3):673-8. Pubmed
  3. Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. Epub 2006 May 24. Pubmed
  4. Kesiova M, Alexandrova A, Yordanova N, Kirkova M, Todorov S: Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacol Rep. 2006 Mar-Apr;58(2):221-8. Pubmed
  5. Lesclous P, Schramm F, Gallina S, Baroukh B, Guez D, Saffar JL: Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats. Exp Physiol. 2006 May;91(3):561-70. Epub 2006 Mar 2. Pubmed
  6. Amagase K, Okabe S: On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion. J Pharmacol Sci. 2003 Jun;92(2):124-36. Pubmed
  7. Weydert JA, Ball TM, Davis MF: Systematic review of treatments for recurrent abdominal pain. Pediatrics. 2003 Jan;111(1):e1-11. Pubmed
  8. Miyata K, Kamato T, Nishida A, Honda K: Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol. 1991 Feb;55(2):211-22. Pubmed
  9. Leurs R, Brozius MM, Smit MJ, Bast A, Timmerman H: Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine. Br J Pharmacol. 1991 Jan;102(1):179-85. Pubmed
  10. Inan A, Sen M, Surgit O, Ergin M, Bozer M: Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo). 2009;64(6):567-70. Pubmed
  11. Ojiako K, Shingala H, Schorr C, Gerber DR: Famotidine versus pantoprazole for preventing bleeding in the upper gastrointestinal tract of critically ill patients receiving mechanical ventilation. Am J Crit Care. 2008 Mar;17(2):142-7. Pubmed

Enzymes

1. Cytochrome P450 2C19

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Transporters

1. Solute carrier family 22 member 2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 2 O15244 Details

References:

  1. Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. Pubmed

2. Solute carrier family 22 member 8

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 8 Q8TCC7 Details

References:

  1. Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. Pubmed
  2. Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. Pubmed
  3. Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y: Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther. 2006 Mar;316(3):1187-94. Epub 2005 Nov 16. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:12