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Identification
NameOxymetazoline
Accession NumberDB00935  (APRD01158)
TypeSmall Molecule
GroupsApproved
Description

A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)

Structure
Thumb
Synonyms
2-(4-Tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline
3-[(4,5-dihydro-1H-Imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol
6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol
6-Tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol
Oximetazolinum
Oxymetazolina
Oxymetazolinum
Oxymethazoline
Oxymetozoline
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Clirol Nasal Sprayspray0.5 %nasalComplex Pharma Inc.Not applicableNot applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
12 Hour Nasalspray.05 g/100mLnasalAltaire Pharmaceuticals Inc.2001-06-01Not applicableUs
12 Hour Nasalspray.05 g/100mLnasalSelect Brand Distributors2000-03-01Not applicableUs
12 Hour Nasalspray.05 g/100mLnasalMeijer Distribution Inc2015-05-06Not applicableUs
12 Hour Original Nasal Decongestantliquid50 mg/100mLnasalFaria Llc Dba Sheffield Pharmaceutical2014-05-30Not applicableUs
7 Select Nasalspray.05 g/100mLnasal7 Eleven2014-08-05Not applicableUs
Afrin Coldspray0.05 mgnasalSchering Plough Canada Inc2002-09-282006-08-01Canada
Afrin No Drip Extra Moisturizingspray, metered.05 g/100mLnasalBayer Health Care Llc2000-08-31Not applicableUs
Afrin No Drip Original Pump Mistspray, metered.05 g/100mLnasalBayer Health Care Llc1999-08-31Not applicableUs
Afrin No Drip Severe Congestionspray, metered.05 g/100mLnasalBayer Health Care Llc2000-08-31Not applicableUs
Afrin No Drip Sinus Pump Mistspray, metered.05 g/100mLnasalMSD Consumer Care, Inc.2000-08-31Not applicableUs
Afrin Originalspray.05 g/100mLnasalMSD Consumer Care, Inc.1975-07-14Not applicableUs
Afrin Original Pump Mistspray, metered.05 g/100mLnasalMSD Consumer Care, Inc.1975-07-14Not applicableUs
Afrin Severe Congestionspray.05 g/100mLnasalMSD Consumer Care, Inc.2000-08-31Not applicableUs
Afrin Sinusspray.05 g/100mLnasalMSD Consumer Care, Inc.1996-08-30Not applicableUs
Anefrin Nasalspray.05 g/100mLnasalWalgreen Company2009-08-28Not applicableUs
Anefrin Nasal Extra Moisturizingspray.05 g/100mLnasalWalgreen Company1994-07-01Not applicableUs
Anefrin Nasal Originalspray.05 g/100mLnasalWalgreen Company1995-09-28Not applicableUs
Assured Nasal Reliefspray.05 mg/100mLnasalGreenbrier International, Inc.2013-04-30Not applicableUs
Assured Nasal Reliefspray.05 mg/100mLnasalUNITED EXCHANGE CORP.2013-11-20Not applicableUs
Assured Nasal Relief Originalspray.05 g/100mLnasalGreenbrier International, Inc.2011-03-08Not applicableUs
Assured Severe Congestion Nasal Reliefspray.2 mg/.4mLnasalGreenbrier International, Inc2015-05-14Not applicableUs
Being Well Nasal 12 Hourspray.05 g/100mLnasalSave A Lot Food Stores Ltd2006-02-25Not applicableUs
Breaze Nasal Moisturizingspray.5 mg/mLnasalSamson Pharmaceuticals, Inc.2015-01-01Not applicableUs
Breaze Nasal Sinus Colds and Allergiesspray.5 mg/mLnasalSamson Pharmaceuticals, Inc.2015-01-01Not applicableUs
Care One Nasalspray.05 g/100mLnasalAmerican Sales Company2004-07-20Not applicableUs
Care One Nasal Extra Moisturizingspray.05 g/100mLnasalAmerican Sales Company2004-06-01Not applicableUs
Care One Nasal Originalspray.05 g/100mLnasalAmerican Sales Company2004-05-24Not applicableUs
Care One Nasal Sinusspray.05 g/100mLnasalAmerican Sales Company2004-05-24Not applicableUs
Circle K Congestion Reliefspray.05 g/100mLnasalLil' Drug Store Products, Inc2014-11-01Not applicableUs
Claritin Allergy Decongestantsolution0.05 %nasalBayer Inc Consumer Care2001-05-02Not applicableCanada
Claritin Eye Allergy Reliefdrops.25 mgophthalmicSchering Plough Canada Inc2001-05-022012-07-24Canada
Clear Timespray.05 g/100mLnasalHy Vee Inc2015-07-19Not applicableUs
Cleartimespray.05 g/100mLnasalWestern Family Foods Inc2015-05-13Not applicableUs
Congestion Relief Lil Drug Store Productsspray.05 g/100mLnasalLil' Drug Store Products, Inc2014-12-01Not applicableUs
Cooling Menthol Nasal Sprayspray, metered dose0.05 %nasalActavis Pharma Company2015-07-08Not applicableCanada
Decongestant Nasalsolution.05 g/100mLnasalSalado Sales Inc.2000-02-01Not applicableUs
Decongestant Nasal Mist Long Lastingsolution0.05 %nasalLaboratoires Confab Inc1996-10-31Not applicableCanada
Dg Health Clear Timespray.05 g/100mLnasalDolgencorp, LLC2015-05-01Not applicableUs
Dg Health Nasal Originalspray.05 g/100mLnasalDolgencorp, LLC2010-01-08Not applicableUs
Dg Health Sinus Reliefspray.05 mg/100mLnasalDolgencorp Inc2010-02-22Not applicableUs
Dristan 12 Hrspray.5 mg/mLnasalPfizer Consumer Healthcare2004-01-01Not applicableUs
Drixoral Decongestant Nasal Spraysolution0.05 %nasalBayer Inc Consumer Care1986-12-31Not applicableCanada
Drixoral Nasal Congestionspray0.05 %nasalBayer Inc Consumer Care2012-08-15Not applicableCanada
Drixoral No Drip Extra Moisturizingspray0.05 %nasalBayer Inc Consumer Care2002-09-28Not applicableCanada
Drixoral No Drip Original Unscentedspray0.05 %nasalBayer Inc Consumer Care2002-09-28Not applicableCanada
Drixoral No Drip With Calming Chamomilespray0.05 %nasalBayer Inc Consumer Care2011-07-07Not applicableCanada
Drixoral No Drip With Cooling Mentholspray0.05 %nasalBayer Inc Consumer Care2002-09-28Not applicableCanada
Equaline Nasalspray.05 g/100mLnasalSupervalu Inc2014-07-15Not applicableUs
Equate Nasalspray.05 g/100mLnasalWal Mart Stores Inc2007-07-27Not applicableUs
Equate Nasal Originalspray.05 g/100mLnasalWal Mart Stores Inc1990-08-15Not applicableUs
Exchange Select Nasalspray.05 g/100mLnasalArmy & Air Force Exchange Service2014-01-06Not applicableUs
Exchange Select Nasalspray.05 g/100mLnasalArmy & Air Force Exchange Service2011-10-28Not applicableUs
Extra Moisturizingspray.05 g/100mLnasalPublix Super Markets Inc1998-05-07Not applicableUs
Extra Moisturizing Nasal Sprayspray, metered dose0.05 %nasalActavis Pharma Company2015-07-08Not applicableCanada
Family Care Nasal Reliefspray.05 g/100mLnasalUnited Exchange Corp2013-06-30Not applicableUs
Family Care Nasal Reliefspray5 g/100mLnasalUnited Exchange Corp2013-05-31Not applicableUs
Formucare Nasal Spray Originalspray.05 g/100mLnasalAccess Business Group International LLC2007-07-10Not applicableUs
Good Neighbor Pharmacy Nasalspray.05 g/100mLnasalAmerisource Bergen1995-03-16Not applicableUs
Good Neighbor Pharmacy Nasalspray.05 g/100mLnasalAmerisource Bergen2002-03-06Not applicableUs
Good Neighbor Pharmacy Nasalspray.05 g/100mLnasalAmerisource Bergen1990-01-15Not applicableUs
Good Neighbor Pharmacy Nasal Extra Moisturizingspray.05 g/100mLnasalAmerisource Bergen1995-05-04Not applicableUs
Good Sense Nasalspray.05 g/100mLnasalL Perrigo Company1994-03-23Not applicableUs
Good Sense Nasalspray.05 g/100mLnasalL. Perrigo Company1996-04-18Not applicableUs
Good Sense Nasalspray.05 g/100mLnasalL. Perrigo Company2002-05-13Not applicableUs
Good Sense Nasalspray.5 mg/mLnasalL. Perrigo Company1989-09-15Not applicableUs
Health Mart Nasalspray.05 g/100mLnasalMc Kesson2012-01-11Not applicableUs
Health Mart Nasalspray.05 g/100mLnasalMc Kesson2012-01-12Not applicableUs
Health Mart Nasalspray.05 g/100mLnasalMc Kesson2012-01-11Not applicableUs
Healthy Accents Nasalspray.05 g/100mLnasalDZA Brands LLC2008-02-24Not applicableUs
Healthy Accents Nasal Originalspray.05 g/100mLnasalDZA Brands LLC2008-04-01Not applicableUs
Leader Extra Moisturizing Nasalspray.05 mg/100mgnasalCardinal Health2013-08-29Not applicableUs
Leader Nasalspray.05 g/100mLnasalCardinal Health1992-01-22Not applicableUs
Leader Nasalspray.05 g/100mLnasalCardinal Health1996-12-05Not applicableUs
Leader Nasalspray.05 g/100mLnasalCardinal Health2014-12-11Not applicableUs
Leader Nasalspray.05 g/100mLnasalCardinal Health2014-12-04Not applicableUs
Leader Original Nasalspray.05 g/100mLnasalCardinal Health2012-09-30Not applicableUs
Leader Original Nasalspray.05 mg/100mgnasalCardinal Health2013-08-29Not applicableUs
Leader Severe Congestion Nasalspray.05 g/100mLnasalCardinal Health2012-02-14Not applicableUs
Long Lasting Decongestant Nasal Sprayspray0.05 %nasalCrlsNot applicableNot applicableCanada
Long Lasting Dristan Mentholated Nasal Sprayspray0.05 %nasalPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1992-12-31Not applicableCanada
Long Lasting Dristan Nasal Mistspray0.05 %nasalPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1992-12-31Not applicableCanada
Long Lasting Nasal Mistsolution0.05 %nasalJamp Pharma Corporation2004-06-30Not applicableCanada
Long Lasting Nasal Mistliquid0.05 %nasalStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1999-03-082002-07-31Canada
Long Lasting Nasal Mistspray0.05 %nasalPharmascience Inc2003-02-01Not applicableCanada
Mucinex Full Forcesolution.05 g/100mLnasalReckitt Benckiser LLC2011-07-01Not applicableUs
Mucinex Moisture Smartsolution.05 g/100mLnasalReckitt Benckiser LLC2011-07-01Not applicableUs
Mucinex Nasal Full Forcesolution.5 mg/mLnasalReckitt Benckiser LLC2010-06-30Not applicableUs
Mucinex Nasal Moisture Smartsolution.05 g/100mLnasalReckitt Benckiser LLC2011-10-20Not applicableUs
Mucinex Sinus-action Congestion & Sinus Nasal Sprayspray0.05 %nasalReckitt Benckiser (Canada) IncNot applicableNot applicableCanada
Mucinex Sinus-action Moisture Smart Nasal Sprayspray0.05 %nasalReckitt Benckiser (Canada) IncNot applicableNot applicableCanada
Mucinex Sinus-max Full Forcesolution.05 mg/100mLnasalReckitt Benckiser LLC2015-04-15Not applicableUs
Mucinex Sinus-max Full Forcesolution.05 mg/100mLnasalReckitt Benckiser LLC2012-09-01Not applicableUs
Nafrine Pediatric Nasal Spray/drops 0.025%drops; spray.025 %nasal; nilSchering Plough Canada Inc1964-12-312001-07-18Canada
Nasalspray.05 g/100mLnasalCVS Pharmacy1994-07-01Not applicableUs
Nasalspray.05 g/100mLnasalRite Aid Corporation1996-12-05Not applicableUs
Nasalspray.05 g/100mLnasalMeijer Distribution Inc1996-12-13Not applicableUs
Nasalspray5 g/100mLnasalA S Medication Solutions Llc2009-03-17Not applicableUs
Nasalspray.05 g/100mLnasalH E B2015-02-19Not applicableUs
Nasalspray.05 g/100mLnasalHy Vee Inc2002-05-13Not applicableUs
Nasalspray.05 g/100mLnasalShopko Stores Operating Co., LLC2013-07-11Not applicableUs
Nasalspray.05 g/100mLnasalMeijer Distribution Inc2002-09-11Not applicableUs
Nasalspray.05 g/100mLnasalL. Perrigo Company1991-07-29Not applicableUs
Nasalspray.05 g/100mLnasalKroger Company2001-09-24Not applicableUs
Nasalspray.05 g/100mLnasalShopko Stores Operating Co., LLC2013-08-19Not applicableUs
Nasalspray5 g/100mLnasalMajor Pharmaceuticals2009-03-17Not applicableUs
Nasalspray.05 g/100mLnasalRite Aid Corporation2013-09-30Not applicableUs
Nasalspray.05 g/100mLnasalKroger Company2002-11-20Not applicableUs
Nasalspray.05 g/100mLnasalH E B2015-02-03Not applicableUs
Nasalspray.05 g/100mLnasalKroger Company1990-11-15Not applicableUs
Nasalspray.05 g/100mLnasalH E B2014-12-02Not applicableUs
Nasalspray.05 g/100mLnasalRite Aid Corporation2013-12-19Not applicableUs
Nasalspray5 g/100mLnasalPreferred Pharmaceuticals, Inc.2009-03-17Not applicableUs
Nasal 12 Hourspray.05 g/100mLnasalMeijer Distribution Inc1991-12-06Not applicableUs
Nasal 12 Hourspray.05 g/100mLnasalMeijer Distribution Inc1994-05-03Not applicableUs
Nasal Congestion Sprayspray, metered dose0.05 %nasalActavis Pharma Company2015-07-08Not applicableCanada
Nasal Dspray.05 g/100mLnasalWestern Family Foods Inc2014-11-17Not applicableUs
Nasal Dspray.05 g/100mLnasalWestern Family Foods Inc2015-01-26Not applicableUs
Nasal D Originalspray.05 g/100mLnasalWestern Family Foods Inc2014-11-13Not applicableUs
Nasal Decongestantspray.05 g/100mLnasalSafeway2004-06-07Not applicableUs
Nasal Decongestantspray.05 g/100mLnasalSafeway2014-03-05Not applicableUs
Nasal Decongestantspray.05 g/100mLnasalNavarro Discount Pharmacies,LLC2012-10-26Not applicableUs
Nasal Decongestantspray.05 g/100mLnasalKareway Product, Inc.2015-11-23Not applicableUs
Nasal Decongestantspray.05 g/100mLnasalSafeway1994-08-17Not applicableUs
Nasal Decongestantspray.05 g/100mLnasalPromex, LLC2013-12-09Not applicableUs
Nasal Decongestantspray.05 g/100mLnasalKareway Product, Inc.2011-08-12Not applicableUs
Nasal Decongestant Extra Moisturizingspray.05 g/100mLnasalKareway Product, Inc.2011-08-12Not applicableUs
Nasal Decongestant Extra Moisturizing Premier Valuespray.05 mg/mLnasalChain Drug Consortium2014-11-04Not applicableUs
Nasal Decongestant Premier Valuespray.05 mg/mLnasalChain Drug Consortium2014-11-04Not applicableUs
Nasal Decongestant Sinus Premier Valuespray.05 mg/mLnasalChain Drug Consortium2014-11-04Not applicableUs
Nasal Extra Moisturizingspray.05 g/100mLnasalKroger Company1994-06-17Not applicableUs
Nasal Extra Moisturizingspray.05 g/100mLnasalHannaford Brothers Company2006-04-21Not applicableUs
Nasal Extra Moisturizingspray.05 g/100mLnasalHy Vee Inc1999-04-02Not applicableUs
Nasal Mistspray.05 g/100mLnasalShopko Stores Operating Co., LLC2014-09-24Not applicableUs
Nasal Mistspray.05 g/100mLnasalCVS Pharmacy2002-09-04Not applicableUs
Nasal Mist Cvsliquid.05 g/100mLtopicalCVS2015-10-01Not applicableUs
Nasal Mist Cvsliquid.05 g/100mLtopicalCVS2015-10-01Not applicableUs
Nasal Originalspray.05 g/100mLnasalCVS Pharmacy1991-09-18Not applicableUs
Nasal Originalspray.05 g/100mLnasalHy Vee Inc1991-11-18Not applicableUs
Nasal Originalspray.05 g/100mLnasalCVS Pharmacy1989-09-15Not applicableUs
Nasal Reliefspray.5 mg/mLnasalRugby Laboratories2014-07-14Not applicableUs
Nasal Relief 12-hourspray.05 g/100mLnasalRugby Laboratories2012-10-29Not applicableUs
Nasal Sinusspray.05 g/100mLnasalCVS Pharmacy1999-10-05Not applicableUs
Nasalub Nasal Reliefspray.05 g/100mLnasalGenomma Lab Usa, Inc2014-12-02Not applicableUs
No Dripspray.05 g/100mLnasalPublix Super Markets Inc2002-12-26Not applicableUs
No Drip Nasal Mist Originalspray.05 g/100mLnasalCVS Pharmacy2012-09-01Not applicableUs
No Drip Premier Valuespray.05 mg/mLnasalChain Drug Consortium2014-11-04Not applicableUs
No Drip Severe Congestion Premier Valuespray.05 mg/mLnasalChain Drug Consortium2014-11-04Not applicableUs
Nostrillaspray, metered.0005 mL/100mLnasalInsight Pharmaceuticals2009-06-08Not applicableUs
Nostrillaspray, metered.0005 mL/100mLnasalInsight Pharmaceuticals2009-06-08Not applicableUs
Ocuclear Oph Dps 0.025%drops.25 mgophthalmicSchering Plough Canada Inc1982-12-312003-07-14Canada
Originalspray.05 g/100mLnasalPublix Super Markets Inc1991-11-13Not applicableUs
Original Unscented Nasal Sprayspray, metered dose0.05 %nasalActavis Pharma CompanyNot applicableNot applicableCanada
Oxymetazoline HClspray.05 g/100mLnasalPerrigo New York Inc2005-12-05Not applicableUs
Oxymetazoline HClspray.5 mg/mLoralPURINEPHARMA LLC2015-02-09Not applicableUs
Oxymetazoline Hydrochloridespray, metered.2 mg/.4mLnasalDynamic Pharmaceuticals2009-11-04Not applicableUs
Oxymetazoline Hydrochloridespray, metered.5 mg/mLnasalZydus Pharmaceuticals (USA) Inc.2009-09-24Not applicableUs
Oxymetazoline Hydrochloridespray, metered.5 mg/mLnasalRebel Distributors Corp2008-12-11Not applicableUs
Oxymetazoline Hydrochloridespray, metered.5 mg/mLnasalCadila Healthcare Limited2009-09-24Not applicableUs
Oxymetazoline Hydrochloridespray, metered.2 mg/.4mLnasalDynamic Pharmaceuticals2009-11-04Not applicableUs
Oxymetazoline Hydrochloride 12-hourspray.05 g/100mLnasalTaro Pharmaceuticals U.S.A., Inc.2006-02-25Not applicableUs
Oxymetazoline Hydrochloride Nasal Spray 0.05%spray0.05 %nasalNovartis Consumer Health Canada Inc.Not applicableNot applicableCanada
Oxymetazoline Hydrochloride Nasal Spray 0.05% With Moisturizersspray0.05 %nasalNovartis Consumer Health Canada Inc.Not applicableNot applicableCanada
Preferred Plus 12 Hour Nasal Extra Moisturizingspray50 mg/100mLnasalKinray2008-01-31Not applicableUs
Preferred Plus 12 Hour Nasal Originalspray50 mg/100mLnasalKinray2008-01-31Not applicableUs
Preferred Plus Nasalspray.05 g/100mLnasalKinray2014-11-24Not applicableUs
Preferred Plus Nasalspray.05 g/100mLnasalKinray2014-11-24Not applicableUs
Rx Act Nasal Extra Moisturizingspray.05 g/100mLnasalH E B1995-10-12Not applicableUs
Rx Act Nasal Originalspray.05 g/100mLnasalH E B1992-02-03Not applicableUs
Rx Act Nasal Sinusspray.05 g/100mLnasalH E B2000-08-25Not applicableUs
Shopko Extra Moisturizing Nasalspray.05 g/100mLnasalUNITED EXCHANGE CORP.2012-03-01Not applicableUs
Shopko Original Nasalspray.05 g/100mLnasalUNITED EXCHANGE CORP.2012-03-01Not applicableUs
Shopko Severe Congestion Nasalspray.05 g/100mLnasalUNITED EXCHANGE CORP.2012-03-01Not applicableUs
Shoprite Nasalspray.05 g/100mLnasalWakefern Food Corporation2013-07-09Not applicableUs
Signature Care Nasal Decongestantspray.05 g/100mLnasalSafeway2015-07-09Not applicableUs
Signature Care Nasal Decongestantspray.05 g/100mLnasalSafeway2015-08-11Not applicableUs
Sinufrinspray0.05 %nasalNeilmed Pharmaceuticals Inc2015-05-10Not applicableCanada
Sinufrin Neilmedspray7.5 mg/15mLnasalNeil Med Pharmaceuticals Inc2012-07-15Not applicableUs
Sinufrin Plusspray0.05 %nasalNeilmed Pharmaceuticals Inc2015-05-10Not applicableCanada
Sinufrin Plus Neilmedspray7.5 mg/15mLnasalNeil Med Pharmaceuticals, Inc.2012-07-15Not applicableUs
Sinus Reliefspray.05 mg/100mLnasalHy Vee Inc2009-12-07Not applicableUs
Sinus Reliefspray.05 mg/100mLnasalMeijer Distribution Inc2003-08-13Not applicableUs
Sinus Reliefspray.05 mg/100mLnasalWestern Family Foods Inc2010-01-07Not applicableUs
Smart Sense Nasalspray.05 mg/100mLnasalKmart Corporation2014-04-01Not applicableUs
Smart Sense Nasalspray.05 g/100mLnasalKmart Corporation2011-01-26Not applicableUs
Smart Sense Nasal Extra Moisturizingspray.05 g/100mLnasalKmart Corporation2010-11-12Not applicableUs
Smart Sense Nasal Originalspray.05 g/100mLnasalKmart Corporation2010-09-03Not applicableUs
Smart Sense Pump Mistspray.05 g/100mLnasalKmart Corporation2014-01-28Not applicableUs
Smart Sense Sinus Reliefspray.05 mg/100mLnasalKmart Corporation2011-01-26Not applicableUs
Sound Body 12 Hour Nasal Originalspray50 mg/100mLnasalLee Pharmaceuticals2008-01-31Not applicableUs
Sunmark Nasalspray.05 g/100mLnasalMc Kesson2003-06-24Not applicableUs
Sunmark Nasalspray.05 g/100mLnasalMc Kesson2003-09-13Not applicableUs
Sunmark Nasalspray.05 g/100mLnasalMc Kesson2003-09-19Not applicableUs
Sunmark Nasalspray.05 g/100mLnasalMc Kesson2014-09-26Not applicableUs
Sunmark Nasal Originalspray.5 mg/mLnasalMc Kesson2003-06-27Not applicableUs
Sunmark No Dripspray.05 g/100mLnasalMc Kesson2003-09-19Not applicableUs
Todays Health Nasal Relief Extra Moisturizingspray.05 g/100mLnasalTAI GUK PHARM. CO., LTD.2010-11-11Not applicableUs
Todays Health Nasal Relief Originalspray.05 g/100mLnasalTAI GUK PHARM. CO., LTD.2010-10-22Not applicableUs
Todays Health Sinus Nasal Reliefspray.05 g/100mLnasalTAI GUK PHARM. CO., LTD.2010-10-25Not applicableUs
Topcare Clear Timespray.05 g/100mLnasalTopco Associates LLC2015-06-29Not applicableUs
Topcare Nasalspray.05 g/100mLnasalTopco Associates LLC2002-11-26Not applicableUs
Topcare Nasalspray.05 g/100mLnasalTopco Associates LLC1989-12-15Not applicableUs
Topcare Nasalspray.05 g/100mLnasalTopco Associates LLC2015-02-04Not applicableUs
Topcare Nasalspray.05 g/100mLnasalTopco Associates LLC1996-08-06Not applicableUs
Topcare Sinus Reliefspray.05 mg/100mLnasalTopco Associates LLC2009-07-29Not applicableUs
Ultra Fine Mist Premier Valuespray.05 mg/mLnasalChain Drug Consortium2014-11-04Not applicableUs
Up and Up Nasalspray.05 g/100mLnasalTarget Corporation2009-08-12Not applicableUs
Up and Up Nasal Extra Moisturizingspray.05 g/100mLnasalTarget Corporation2010-07-21Not applicableUs
Vicks Qlearquil 12 Hour Decongestant Moisturizingspray.512 mg/mLnasalThe Procter & Gamble Manufacturing Company2014-03-01Not applicableUs
Vicks Sinex 12 Hour Decongestantspray.0005095 g/mLnasalThe Procter & Gamble Manufacturing Company2015-04-27Not applicableUs
Vicks Sinex 12 Hour Decongestant Nasalspray.0005055 g/mLnasalThe Procter & Gamble Manufacturing Company2010-07-06Not applicableUs
Vicks Sinex 12 Hour Decongestant Ultra Fine Mistspray.0005095 g/mLnasalThe Procter & Gamble Manufacturing Company2015-04-27Not applicableUs
Vicks Sinex 12 Hour Decongestant Ultra Fine Mistspray.0005095 g/mLnasalThe Procter & Gamble Manufacturing Company2010-07-06Not applicableUs
Vicks Sinex 12 Hour Decongestant Ultra Fine Mist Moisturizingspray.000512 g/mLnasalThe Procter & Gamble Manufacturing Company2010-07-06Not applicableUs
Vicks Sinex 12 Hour Nasal Decongestant Ultra Fine Mist Moisturizingspray.0005095 g/mLnasalThe Procter & Gamble Manufacturing Company2015-04-27Not applicableUs
Vicks Sinex Decongestant Nasal Spray 0.05%liquid.05 %nasalProcter & Gamble Inc1985-12-31Not applicableCanada
Visine L.R.liquid.25 mg/mLophthalmicJohnson & Johnson Consumer Inc.2010-04-05Not applicableUs
Visine L.R. Ophthalmic Sol 0.025%liquid.025 %ophthalmicPfizer Canada Inc., Consumer Healthcare Division1991-12-311996-09-09Canada
Visine Workplacedrops0.025 %ophthalmicJohnson & Johnson Inc1995-12-31Not applicableCanada
Winco Foods Extra Moisturizing Nasal Reliefspray.005 g/100mLnasalWin Co Foods, Llc2014-11-26Not applicableUs
Winco Foods Original Nasalspray.05 g/100mLnasalWin Co Foods, Llc2014-11-26Not applicableUs
Winco Foods Severe Congestion Nasal Reliefspray.05 g/100mLnasalWin Co Foods, Llc2014-12-01Not applicableUs
Zicamspray.5 mg/mLnasalMatrixx Initiatives, Inc.2002-05-29Not applicableUs
Zicamspray.5 mg/mLnasalMatrixx Initiatives, Inc.2002-05-20Not applicableUs
Zicam Congestion Reliefsolution0.05 %nasalZicam Llc2008-11-272009-11-20Canada
Zicam Sinus Reliefsolution0.05 %nasalZicam Llc2008-11-272009-11-20Canada
Unapproved/Other Products Not Available
International Brands
NameCompany
AfrinNot Available
Dristan 12-HourNot Available
Duramist PlusNot Available
Genasal Nasal Spray Up to 12 Hour ReliefNot Available
IliadinNot Available
Neo-Synephrine 12 Hour SprayNot Available
NezerilNot Available
Nostrilla 12 Hour Nasal DecongestantNot Available
OcuClearNot Available
Vicks Sinex 12 Hour Nasal SprayNot Available
Vicks Sinex 12 Hour Ultra Fine Mist for Sinus ReliefNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Oxymetazoline hydrochloride
Thumb
  • InChI Key: BEEDODBODQVSIM-UHFFFAOYSA-N
  • Monoisotopic Mass: 296.165541139
  • Average Mass: 296.836
DBSALT000821
Categories
UNII8VLN5B44ZY
CAS number1491-59-4
WeightAverage: 260.3746
Monoisotopic: 260.1888634
Chemical FormulaC16H24N2O
InChI KeyInChIKey=WYWIFABBXFUGLM-UHFFFAOYSA-N
InChI
InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
IUPAC Name
6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
SMILES
CC1=CC(=C(O)C(C)=C1CC1=NCCN1)C(C)(C)C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylpropanes
Direct ParentPhenylpropanes
Alternative Parents
Substituents
  • Phenylpropane
  • P-cresol
  • O-cresol
  • Phenol
  • Imidolactam
  • 2-imidazoline
  • Azacycle
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Carboximidamide
  • Carboxylic acid amidine
  • Amidine
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor treatment of nasal congestion and redness associated with minor irritations of the eye
PharmacodynamicsOxymetazoline a adrenergic alpha-agonists, direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. Oxymetazoline elicits relief of conjunctival hyperemia by causing vasoconstriction of superficial conjunctival blood vessels. The drug's action has been demonstrated in acute allergic conjunctivitis and in chemical (chloride) conjunctivitis.
Mechanism of actionOxymetazoline is a direct acting sympathomimetic amine, which acts on alpha-adrenergic receptors in the arterioles of the conjunctiva and nasal mucosa. It produces vasoconstriction, resulting in decreased conjunctival congestion in ophthalmic. In nasal it produces constriction, resulting in decreased blood flow and decreased nasal congestion.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9761
Blood Brain Barrier-0.5388
Caco-2 permeable-0.567
P-glycoprotein substrateSubstrate0.8858
P-glycoprotein inhibitor INon-inhibitor0.9477
P-glycoprotein inhibitor IINon-inhibitor0.6585
Renal organic cation transporterInhibitor0.6039
CYP450 2C9 substrateNon-substrate0.7585
CYP450 2D6 substrateNon-substrate0.5707
CYP450 3A4 substrateNon-substrate0.5394
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8931
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.854
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.7951
CarcinogenicityNon-carcinogens0.8923
BiodegradationNot ready biodegradable1.0
Rat acute toxicity4.4155 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8402
hERG inhibition (predictor II)Non-inhibitor0.7432
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Schering plough healthcare products inc
  • Johnson and johnson group consumer companies
Packagers
Dosage forms
FormRouteStrength
Liquidnasal50 mg/100mL
Spraynasal0.05 mg
Spray, meterednasal.05 g/100mL
Spraynasal.05 mg/100mL
Spraynasal.2 mg/.4mL
Spraynasal0.5 %
Spray, metered dosenasal0.05 %
Solutionnasal0.05 %
Spraynasal.05 g/100mL
Spraynasal.5 mg/mL
Spraynasal.05 mg/100mg
Spraynasal0.05 %
Liquidnasal0.05 %
Solutionnasal.5 mg/mL
Solutionnasal.05 g/100mL
Solutionnasal.05 mg/100mL
Drops; spraynasal; nil.025 %
Spraynasal5 g/100mL
Spraynasal.05 mg/mL
Liquidtopical.05 g/100mL
Spray, meterednasal.0005 mL/100mL
Dropsophthalmic.25 mg
Sprayoral.5 mg/mL
Spray, meterednasal.2 mg/.4mL
Spray, meterednasal.5 mg/mL
Spraynasal7.5 mg/15mL
Spraynasal50 mg/100mL
Spraynasal.512 mg/mL
Spraynasal.0005055 g/mL
Spraynasal.000512 g/mL
Spraynasal.0005095 g/mL
Liquidnasal.05 %
Liquidophthalmic.25 mg/mL
Liquidophthalmic.025 %
Dropsophthalmic0.025 %
Spraynasal.005 g/100mL
Prices
Unit descriptionCostUnit
Oxymetazoline hcl powder84.42USD g
Afrin 0.05% nose spray0.62USD ml
Drixoral cold & allergy tablet sa0.4USD tablet
Afrin no drip sinus pump mist0.38USD ml
Oxymetazoline 0.05% spray0.38USD ml
Anefrin 0.05% nasal spray0.37USD ml
Afrin sinus spray0.33USD ml
Dristan long lasting mist0.32USD ml
Neo-synephrine 12 hour spray0.28USD ml
Visine long lasting eye drops0.27USD ml
12 hour nasal relief spray0.24USD ml
Dristan cold multi-symp tablet0.23USD tablet
Ocuclear eye drops0.23USD ml
CVS Pharmacy nasal spray 0.05%0.22USD ml
No drip 0.05% nasal spray0.13USD ml
Nasal spray 0.05%0.06USD ml
Sinus nasal spray0.06USD ml
Nasal decongestant 0.05% spray0.03USD ml
Pv nasal spray 0.05%0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point182 °CPhysProp
logP3.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0515 mg/mLALOGPS
logP3.7ALOGPS
logP3.03ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)10.91ChemAxon
pKa (Strongest Basic)10.15ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area44.62 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity79.8 m3·mol-1ChemAxon
Polarizability30.64 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (10.5 KB)
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesR01AA05R01AB07S01GA04
AHFS Codes
  • 52:32.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74.6 KB)
Interactions
Drug Interactions
Drug
AcebutololThe risk or severity of adverse effects can be increased when Acebutolol is combined with Oxymetazoline.
AcetaminophenThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Acetaminophen.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Acetylsalicylic acid.
AlfuzosinAlfuzosin may decrease the vasoconstricting activities of Oxymetazoline.
AminophyllineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Aminophylline.
AmitriptylineAmitriptyline may increase the activities of Oxymetazoline.
AmphetamineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Amphetamine.
ArformoterolThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Arformoterol.
ArmodafinilThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Armodafinil.
ArticaineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Articaine.
AtomoxetineAtomoxetine may increase the hypertensive activities of Oxymetazoline.
BenzphetamineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Benzphetamine.
ButalbitalThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Butalbital.
CabergolineCabergoline may increase the hypertensive activities of Oxymetazoline.
CaffeineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Caffeine.
ChlorphentermineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Oxymetazoline.
ClenbuterolThe risk or severity of adverse effects can be increased when Clenbuterol is combined with Oxymetazoline.
CocaineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Cocaine.
DexmethylphenidateThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Dexmethylphenidate.
DextroamphetamineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Dextroamphetamine.
DiethylpropionThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Diethylpropion.
DihydrocodeineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Dihydrocodeine.
DipivefrinThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Dipivefrin.
DobutamineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Dobutamine.
DopamineThe risk or severity of adverse effects can be increased when Dopamine is combined with Oxymetazoline.
DoxapramThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Doxapram.
DoxofyllineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Doxofylline.
DronabinolDronabinol may increase the tachycardic activities of Oxymetazoline.
DyphyllineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Dyphylline.
EphedrineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Ephedrine.
EpinephrineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Epinephrine.
FenoterolThe risk or severity of adverse effects can be increased when Fenoterol is combined with Oxymetazoline.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Oxymetazoline.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Fluticasone Propionate.
FormoterolThe risk or severity of adverse effects can be increased when Formoterol is combined with Oxymetazoline.
IndacaterolThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Indacaterol.
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Oxymetazoline.
Ipratropium bromideThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Ipratropium bromide.
IsomethepteneThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Isometheptene.
IsoprenalineThe risk or severity of adverse effects can be increased when Isoprenaline is combined with Oxymetazoline.
LabetalolThe risk or severity of adverse effects can be increased when Labetalol is combined with Oxymetazoline.
LevonordefrinThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Levonordefrin.
LinezolidLinezolid may increase the hypertensive activities of Oxymetazoline.
LisdexamfetamineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Lisdexamfetamine.
MephentermineThe risk or severity of adverse effects can be increased when Mephentermine is combined with Oxymetazoline.
MepivacaineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Mepivacaine.
MetaraminolThe risk or severity of adverse effects can be increased when Metaraminol is combined with Oxymetazoline.
MethamphetamineThe risk or severity of adverse effects can be increased when Methamphetamine is combined with Oxymetazoline.
MethoxamineThe risk or severity of adverse effects can be increased when Methoxamine is combined with Oxymetazoline.
MethylphenidateThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Methylphenidate.
MidodrineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Midodrine.
ModafinilThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Modafinil.
NabiloneNabilone may increase the tachycardic activities of Oxymetazoline.
NaphazolineThe risk or severity of adverse effects can be increased when Naphazoline is combined with Oxymetazoline.
NorepinephrineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Norepinephrine.
OlodaterolThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Olodaterol.
OrciprenalineThe risk or severity of adverse effects can be increased when Orciprenaline is combined with Oxymetazoline.
PhendimetrazineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Phendimetrazine.
PhenelzinePhenelzine may increase the hypertensive activities of Oxymetazoline.
PheniramineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Pheniramine.
PhenmetrazineThe risk or severity of adverse effects can be increased when Phenmetrazine is combined with Oxymetazoline.
PhentermineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Phentermine.
PhenylephrineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Phenylephrine.
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Oxymetazoline.
PirbuterolThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Pirbuterol.
PrazosinPrazosin may decrease the vasoconstricting activities of Oxymetazoline.
PropylhexedrineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Propylhexedrine.
PseudoephedrineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Pseudoephedrine.
RacepinephrineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Racepinephrine.
RitodrineThe risk or severity of adverse effects can be increased when Ritodrine is combined with Oxymetazoline.
SalbutamolThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Salbutamol.
SalmeterolThe risk or severity of adverse effects can be increased when Salmeterol is combined with Oxymetazoline.
Tedizolid PhosphateTedizolid Phosphate may increase the hypertensive activities of Oxymetazoline.
TerbutalineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Terbutaline.
TheophyllineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Theophylline.
TranylcypromineTranylcypromine may increase the hypertensive activities of Oxymetazoline.
TriprolidineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Triprolidine.
VilanterolThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Vilanterol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular Weight:
51486.005 Da
References
  1. Yang HT, Endoh M: (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart. Eur J Pharmacol. 1996 Oct 3;312(3):281-91. [PubMed:8894610 ]
  2. Deplanne V, Galzin AM: Functional characterization of alpha-1-adrenoceptor subtypes in the prostatic urethra and trigone of male rabbit. J Pharmacol Exp Ther. 1996 Aug;278(2):527-34. [PubMed:8768700 ]
  3. Shibata K, Taketani K: [Excitatory effect of noradrenaline on rat airway parasympathetic ganglion neurons]. Fukuoka Igaku Zasshi. 2001 Nov;92(11):377-83. [PubMed:11774707 ]
  4. Furukawa K, Rosario DJ, Smith DJ, Chapple CR, Uchiyama T, Chess-Williams R: Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens. Br J Pharmacol. 1995 Sep;116(1):1605-10. [PubMed:8564226 ]
  5. Gonzalez-Espinosa C, Romero-Avila MT, Mora-Rodriguez DM, Gonzalez-Espinosa D, Garcia-Sainz JA: Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor. Eur J Pharmacol. 2001 Aug 31;426(3):147-55. [PubMed:11527538 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Thioesterase binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianser...
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular Weight:
48956.275 Da
References
  1. MacKinnon AC, Kilpatrick AT, Kenny BA, Spedding M, Brown CM: [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification. Br J Pharmacol. 1992 Aug;106(4):1011-8. [PubMed:1327384 ]
  2. Mitrani P, Srinivasan M, Dodds C, Patel MS: Role of the autonomic nervous system in the development of hyperinsulinemia by high-carbohydrate formula feeding to neonatal rats. Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1069-78. Epub 2006 Dec 12. [PubMed:17164433 ]
  3. Lepretre N, Mironneau J: Alpha 2-adrenoceptors activate dihydropyridine-sensitive calcium channels via Gi-proteins and protein kinase C in rat portal vein myocytes. Pflugers Arch. 1994 Dec;429(2):253-61. [PubMed:7892112 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Protein homodimerization activity
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Gene Name:
ADRA2C
Uniprot ID:
P18825
Molecular Weight:
49521.585 Da
References
  1. Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bonisch H: Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. doi: 10.1111/j.1472-8206.2009.00805.x. [PubMed:20030735 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Epinephrine binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phent...
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular Weight:
49565.8 Da
References
  1. Uhlen S, Wikberg JE: Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound. Eur J Pharmacol. 1991 Sep 17;202(2):235-43. [PubMed:1666366 ]
  2. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP: ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1100-7. doi: 10.1093/nar/gkr777. Epub 2011 Sep 23. [PubMed:21948594 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bonisch H: Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. doi: 10.1111/j.1472-8206.2009.00805.x. [PubMed:20030735 ]
  2. Akinaga J, Lima V, Kiguti LR, Hebeler-Barbosa F, Alcantara-Hernandez R, Garcia-Sainz JA, Pupo AS: Differential phosphorylation, desensitization, and internalization of alpha1A-adrenoceptors activated by norepinephrine and oxymetazoline. Mol Pharmacol. 2013 Apr;83(4):870-81. doi: 10.1124/mol.112.082313. Epub 2013 Jan 30. [PubMed:23364786 ]
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP: ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1100-7. doi: 10.1093/nar/gkr777. Epub 2011 Sep 23. [PubMed:21948594 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Alpha1-adrenergic receptor activity
Specific Function:
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
Gene Name:
ADRA1D
Uniprot ID:
P25100
Molecular Weight:
60462.205 Da
References
  1. Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bonisch H: Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. doi: 10.1111/j.1472-8206.2009.00805.x. [PubMed:20030735 ]
  2. Akinaga J, Lima V, Kiguti LR, Hebeler-Barbosa F, Alcantara-Hernandez R, Garcia-Sainz JA, Pupo AS: Differential phosphorylation, desensitization, and internalization of alpha1A-adrenoceptors activated by norepinephrine and oxymetazoline. Mol Pharmacol. 2013 Apr;83(4):870-81. doi: 10.1124/mol.112.082313. Epub 2013 Jan 30. [PubMed:23364786 ]
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP: ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1100-7. doi: 10.1093/nar/gkr777. Epub 2011 Sep 23. [PubMed:21948594 ]
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:12