Showing BioInteractions for Oxymetazoline (DB00935)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 11
Enzyme Mediated Interactions 2

	Interacting Group	Interacting Drugs
	Oxymetazoline is a Alpha-1A adrenergic receptor partial agonist
1	Alpha-1A adrenergic receptor agonists	4-Methoxyamphetamine, Apraclonidine, Benzphetamine, Bromocriptine, Cirazoline, Clonidine, Dipivefrin, Droxidopa, Ephedrine, Epinephrine, Ergometrine, Isometheptene, Lofexidine, Metaraminol, Methoxamine, Midodrine, Naphazoline, Norepinephrine, Pergolide, Phendimetrazine, Phenylephrine, Pseudoephedrine, Racepinephrine, Tetryzoline, Xylometazoline
2	Alpha-1A adrenergic receptor antagonists	Acepromazine, Alfuzosin, Amitriptyline, Amoxapine, Aripiprazole, Aripiprazole lauroxil, Asenapine, Bevantolol, Bromocriptine, Carvedilol, Chlorpromazine, Clozapine, Dapiprazole, Doxazosin, Doxepin, Dronedarone, Droperidol, Flupentixol, Iloperidone, Imipramine, Indoramin, Methotrimeprazine, Nefazodone, Nicardipine, Nicergoline, Niguldipine, Nortriptyline, Olanzapine, Paliperidone, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Promazine, Propiomazine, Propiverine, Quinidine, Risperidone, Silodosin, Tamsulosin, Terazosin, Thioproperazine, Thioridazine, Tolazoline, Trazodone, Trifluoperazine, Trimipramine, Verapamil, Ziprasidone, Zuclopenthixol
3	Alpha-1A adrenergic receptor partial agonists	Ergotamine, Xylometazoline
4	Alpha-1A adrenergic receptor potentiators	Carvedilol
5	Alpha-1A adrenergic receptor inhibitors	Amitriptyline, Fenoldopam, Lamotrigine
6	Alpha-1A adrenergic receptor binders	Cabergoline, Loxapine

	Interacting Group	Interacting Drugs
	Oxymetazoline is a Alpha-2A adrenergic receptor agonist
1	Alpha-2A adrenergic receptor agonists	4-Methoxyamphetamine, Amitriptyline, Apomorphine, Apraclonidine, Benzphetamine, Brimonidine, Bromocriptine, Clonidine, Dexmedetomidine, Dihydroergotamine, Dipivefrin, DL-Methylephedrine, Droxidopa, Ephedra sinica root, Epinephrine, Guanabenz, Guanfacine, Lofexidine, Metamfetamine, Moxonidine, Naphazoline, Norepinephrine, Pramipexole, Pseudoephedrine, Racepinephrine, Xylometazoline
2	Alpha-2A adrenergic receptor antagonists	Amitriptyline, Amoxapine, Aripiprazole, Asenapine, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Methotrimeprazine, Mianserin, Mirtazapine, Nefazodone, Paliperidone, Periciazine, Phenoxybenzamine, Phentolamine, Pipamperone, Pirlindole, Pizotifen, Quetiapine, Tolazoline, Trazodone, Yohimbine, Ziprasidone, Zuclopenthixol
3	Alpha-2A adrenergic receptor partial agonists	Ergotamine
4	Alpha-2A adrenergic receptor binders	Loxapine, Prazosin
5	Alpha-2A adrenergic receptor inhibitors	Lamotrigine

	Interacting Group	Interacting Drugs
	Oxymetazoline is a Alpha-2A adrenergic receptor partial agonist
1	Alpha-2A adrenergic receptor agonists	4-Methoxyamphetamine, Amitriptyline, Apomorphine, Apraclonidine, Benzphetamine, Brimonidine, Bromocriptine, Clonidine, Dexmedetomidine, Dihydroergotamine, Dipivefrin, DL-Methylephedrine, Droxidopa, Ephedra sinica root, Epinephrine, Guanabenz, Guanfacine, Lofexidine, Metamfetamine, Moxonidine, Naphazoline, Norepinephrine, Pramipexole, Pseudoephedrine, Racepinephrine, Xylometazoline
2	Alpha-2A adrenergic receptor antagonists	Amitriptyline, Amoxapine, Aripiprazole, Asenapine, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Methotrimeprazine, Mianserin, Mirtazapine, Nefazodone, Paliperidone, Periciazine, Phenoxybenzamine, Phentolamine, Pipamperone, Pirlindole, Pizotifen, Quetiapine, Tolazoline, Trazodone, Yohimbine, Ziprasidone, Zuclopenthixol
3	Alpha-2A adrenergic receptor partial agonists	Ergotamine
4	Alpha-2A adrenergic receptor binders	Loxapine, Prazosin
5	Alpha-2A adrenergic receptor inhibitors	Lamotrigine

	Interacting Group	Interacting Drugs
	Oxymetazoline is a Alpha-2C adrenergic receptor agonist
1	Alpha-2C adrenergic receptor antagonists	Aripiprazole, Asenapine, Brexpiprazole, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Iloperidone, Lurasidone, Methotrimeprazine, Mianserin, Phenoxybenzamine, Pizotifen, Quetiapine, Risperidone, Yohimbine, Ziprasidone
2	Alpha-2C adrenergic receptor agonists	Agmatine, Apomorphine, Brimonidine, Bromocriptine, Clonidine, Droxidopa, Ephedra sinica root, Metamfetamine, Norepinephrine, Paliperidone, Racepinephrine, Xylometazoline
3	Alpha-2C adrenergic receptor binders	Loxapine, Tolazoline

	Interacting Group	Interacting Drugs
	Oxymetazoline is a Alpha-2B adrenergic receptor agonist
1	Alpha-2B adrenergic receptor antagonists	Aripiprazole, Asenapine, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Methotrimeprazine, Mianserin, Paliperidone, Phenoxybenzamine, Pizotifen, Quetiapine, Risperidone, Rotigotine, Yohimbine, Ziprasidone
2	Alpha-2B adrenergic receptor agonists	Apomorphine, Apraclonidine, Brimonidine, Bromocriptine, Clonidine, Droxidopa, Ephedra sinica root, Epinephrine, Etomidate, Metamfetamine, Norepinephrine, Racepinephrine, Xylometazoline
3	Alpha-2B adrenergic receptor ligands	Aripiprazole
4	Alpha-2B adrenergic receptor binders	Guanabenz, Guanfacine, Loxapine, Prazosin, Tolazoline

	Interacting Group	Interacting Drugs
	Oxymetazoline is a Alpha-1B adrenergic receptor agonist
1	Alpha-1B adrenergic receptor antagonists	Acepromazine, Alfuzosin, Amitriptyline, Aripiprazole, Aripiprazole lauroxil, Brexpiprazole, Bromocriptine, Carvedilol, Chlorpromazine, Clozapine, Dapiprazole, Dextroamphetamine, Doxepin, Dronedarone, Imipramine, Methotrimeprazine, Nicardipine, Nortriptyline, Olanzapine, Paliperidone, Periciazine, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Quinidine, Risperidone, Silodosin, Tamsulosin, Terazosin, Thioproperazine, Thioridazine, Trimipramine, Verapamil, Ziprasidone
2	Alpha-1B adrenergic receptor partial agonists	Cirazoline, Ergotamine, Modafinil
3	Alpha-1B adrenergic receptor agonists	Bromocriptine, Clonidine, Droxidopa, Epinephrine, Methoxamine, Midodrine, Norepinephrine, Pergolide, Phendimetrazine, Phenylephrine, Racepinephrine, Xylometazoline
4	Alpha-1B adrenergic receptor binders	Cabergoline, Loxapine
5	Alpha-1B adrenergic receptor inhibitors	Fenoldopam

	Interacting Group	Interacting Drugs
	Oxymetazoline is a Alpha-1D adrenergic receptor agonist
1	Alpha-1D adrenergic receptor antagonists	Alfuzosin, Amitriptyline, Carvedilol, Dapiprazole, Doxazosin, Doxepin, Dronedarone, Epinephrine, Imipramine, Methotrimeprazine, Nicardipine, Nortriptyline, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Quinidine, Racepinephrine, Silodosin, Tamsulosin, Terazosin, Verapamil
2	Alpha-1D adrenergic receptor agonists	Bromocriptine, Clonidine, Droxidopa, Midodrine, Norepinephrine, Pergolide, Phenylephrine, Xylometazoline
3	Alpha-1D adrenergic receptor partial agonists	Cirazoline, Ergotamine
4	Alpha-1D adrenergic receptor inhibitors	Fenoldopam
5	Alpha-1D adrenergic receptor binders	Cabergoline, Methoxamine

	Interacting Group	Interacting Drugs
	Oxymetazoline is a 5-hydroxytryptamine receptor 1A agonist
1	5-hydroxytryptamine receptor 1A partial agonists	Aripiprazole, Aripiprazole lauroxil, Brexpiprazole, Buspirone, Cariprazine, Perospirone, Quetiapine, Trazodone, Yohimbine
2	5-hydroxytryptamine receptor 1A agonists	5-methoxy-N,N-dimethyltryptamine, Apomorphine, Brexpiprazole, Bromocriptine, Cabergoline, Cannabidiol, Cariprazine, Cinitapride, Eletriptan, Ergotamine, Fenfluramine, Flibanserin, Lisuride, Lofexidine, Methysergide, Naluzotan, Naratriptan, Pergolide, Pramipexole, Rotigotine, SEP-363856, Sumatriptan, Tetrahydrocannabivarin, Vilazodone, Vortioxetine, Ziprasidone, Zolmitriptan
3	5-hydroxytryptamine receptor 1A antagonists	Acepromazine, Alprenolol, Alverine, Amoxapine, Asenapine, Chlorpromazine, Clozapine, Dosulepin, Doxepin, Iloperidone, Lurasidone, Molindone, Nefazodone, Nortriptyline, Paliperidone, Penbutolol, Pindolol, Pipotiazine, Pirlindole, Pizotifen, Quetiapine, Risperidone, Trazodone, Trimipramine
4	5-hydroxytryptamine receptor 1A inhibitors	Amitriptyline, Escitalopram, Tianeptine
5	5-hydroxytryptamine receptor 1A inducers	Amitriptyline
6	5-hydroxytryptamine receptor 1A binders	Desipramine, Dopamine, Loxapine
7	5-hydroxytryptamine receptor 1A activators	Imipramine
8	5-hydroxytryptamine receptor 1A blockers	Mianserin

	Interacting Group	Interacting Drugs
	Oxymetazoline is a 5-hydroxytryptamine receptor 1B agonist
1	5-hydroxytryptamine receptor 1B agonists	Almotriptan, Apomorphine, Bromocriptine, Cabergoline, Dihydroergotamine, Eletriptan, Ergotamine, Frovatriptan, Lisuride, Naratriptan, Pergolide, Rizatriptan, Sumatriptan, Zolmitriptan
2	5-hydroxytryptamine receptor 1B antagonists	Amoxapine, Aripiprazole, Asenapine, Clozapine, Penbutolol, Pizotifen, Ziprasidone
3	5-hydroxytryptamine receptor 1B ligands	Aripiprazole, Quetiapine
4	5-hydroxytryptamine receptor 1B partial agonists	Vortioxetine, Yohimbine
5	5-hydroxytryptamine receptor 1B binders	Amitriptyline, Loxapine, Methysergide

	Interacting Group	Interacting Drugs
	Oxymetazoline is a 5-hydroxytryptamine receptor 1D agonist
1	5-hydroxytryptamine receptor 1D agonists	Almotriptan, Apomorphine, Bromocriptine, Cabergoline, Dihydroergotamine, Eletriptan, Ergotamine, Fenfluramine, Frovatriptan, Lisuride, Lofexidine, Naratriptan, Pergolide, Rizatriptan, Sumatriptan, Zolmitriptan
2	5-hydroxytryptamine receptor 1D antagonists	Aripiprazole, Clozapine, Paliperidone, Pizotifen, Risperidone, Ziprasidone
3	5-hydroxytryptamine receptor 1D ligands	Aripiprazole, Quetiapine
4	5-hydroxytryptamine receptor 1D partial agonists	Yohimbine
5	5-hydroxytryptamine receptor 1D binders	Amitriptyline, Loxapine, Trimipramine

	Interacting Group	Interacting Drugs
	Oxymetazoline is a 5-hydroxytryptamine receptor 1C partial agonist
1	5-hydroxytryptamine receptor 1C antagonists	Amitriptyline, Nortriptyline, Trazodone
2	5-hydroxytryptamine receptor 1C binders	Trimipramine
3	5-hydroxytryptamine receptor 1C partial agonists	Trazodone

	Interacting Group	Interacting Drugs
	Oxymetazoline is a UDP-glucuronosyltransferase 1-9 substrate
1	UDP-glucuronosyltransferase 1-9 substrates	Acetaminophen, Ambrisentan, Artenimol, Artesunate, Ataluren, Cabotegravir, Canagliflozin, Dabigatran etexilate, Dapagliflozin, Dexibuprofen, Diclofenac, Dolutegravir, Empagliflozin, Enasidenib, Entacapone, Ertugliflozin, Ethinylestradiol, Etodolac, Ezogabine, Febuxostat, Fenofibrate, Flurbiprofen, Formoterol, Fostamatinib, Gavestinel, Gemfibrozil, Glasdegib, Haloperidol, Ibuprofen, Indomethacin, Irinotecan, Ketobemidone, Labetalol, Lumiracoxib, Mycophenolate mofetil, Mycophenolic acid, Naproxen, Nateglinide, Oxazepam, Phenytoin, Propacetamol, Propofol, Regorafenib, Seratrodast, Sorafenib, Tapentadol, Topiroxostat, Troglitazone, Umifenovir, Vadimezan, Valdecoxib, Valproic acid, Vericiguat, Zileuton
2	UDP-glucuronosyltransferase 1-9 inhibitors	Deferasirox, Diflunisal, Eltrombopag, Fosphenytoin, Isavuconazole, Mefenamic acid, Methylene blue, Morniflumate, Niflumic acid, Phenytoin, Regorafenib, Rifampicin, Sorafenib, Umifenovir

	Interacting Group	Interacting Drugs
	Oxymetazoline is a Cytochrome P450 2C19 substrate
1	Cytochrome P450 2C19 substrates	(R)-warfarin, (S)-Warfarin, Acenocoumarol, Adinazolam, Albendazole, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Bupivacaine, Cannabidiol, Capravirine, Carisoprodol, Cenobamate, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clobazam, Clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Dexibuprofen, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Doxazosin, Doxepin, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esketamine, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Fedratinib, Fenfluramine, Flunitrazepam, Fluoxetine, Formoterol, Fosphenytoin, Gliclazide, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Hydrocodone, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Lonafarnib, Loratadine, Lorcaserin, Lorlatinib, Lovastatin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Methadone, Methsuximide, Methylene blue, Methylphenobarbital, Moclobemide, Nabiximols, Nebivolol, Nelfinavir, Nicotine, Nilutamide, Norethisterone, Nortriptyline, Oliceridine, Omeprazole, Ospemifene, Oxiconazole, Pantoprazole, Paroxetine, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Pirfenidone, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Rilpivirine, Romidepsin, Rupatadine, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Simvastatin, St. John's Wort, Stiripentol, Tamoxifen, Tapentadol, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Triclabendazole, Trimethadione, Trimipramine, Valproic acid, Verapamil, Vilazodone, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Zolpidem, Zonisamide
2	Cytochrome P450 2C19 inhibitors	Abiraterone, Alpelisib, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Avasimibe, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Casimersen, Cenobamate, Chloramphenicol, Cimetidine, Cisapride, Citalopram, Clascoterone, Clevidipine, Clinafloxacin, Clozapine, Curcumin sulfate, Cyclosporine, Dabrafenib, Delavirdine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Duloxetine, Elexacaftor, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Esomeprazole, Ethambutol, Ethanol, Ethinylestradiol, Etoricoxib, Etravirine, Felbamate, Fenofibrate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gestodene, Idelalisib, Imipramine, Indomethacin, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Letrozole, Lobeglitazone, Lonafarnib, Lopinavir, Loratadine, Losartan, Luliconazole, Lynestrenol, Manidipine, Memantine, Menadione, Mephenytoin, Methimazole, Methsuximide, Methylene blue, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Osilodrostat, Oxcarbazepine, Pantoprazole, Phenelzine, Piperaquine, Progesterone, Quinine, Rabeprazole, Rifamycin, Rilpivirine, Rucaparib, Safinamide, Seproxetine, Sertraline, Sildenafil, Sitaxentan, Somapacitan, Somatotropin, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Tirbanibulin, Topiramate, Topiroxostat, Tranylcypromine, Triclabendazole, Troglitazone, Ubrogepant, Valproic acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3	Cytochrome P450 2C19 inducers	Acetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Betamethasone, Budesonide, Carbamazepine, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enzalutamide, Hydrocortisone, Hydroxyprogesterone caproate, Letermovir, Lumacaftor, Methylprednisolone, Midostaurin, Nelfinavir, Norethisterone, Opicapone, Phenobarbital, Phenytoin, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, St. John's Wort