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Identification
NameFexofenadine
Accession NumberDB00950  (APRD00349)
TypeSmall Molecule
GroupsApproved
DescriptionFexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.
Structure
Thumb
Synonyms
4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid
Carboxyterfenadine
Fexofenadine
Terfenadine acid metabolite
Terfenadine carboxylate
Terfenadine-COOH
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Allegrasuspension6 mg/mLoralSanofi Aventis U.S. Llc2006-10-16Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-02-25Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-02-25Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Fexofenadine Hydrochloridetablet60 mg/1oralREMEDYREPACK INC.2011-08-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralPd Rx Pharmaceuticals, Inc.2010-05-21Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Fexofenadine Hydrochloridetablet60 mg/1oralRebel Distributors Corp2009-12-09Not applicableUs
Fexofenadine Hydrochloridetablet60 mg/1oralREMEDYREPACK INC.2011-08-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralDIRECT RX2015-12-03Not applicableUs
Fexofenadine Hydrochloridetablet, film coated30 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralPhysicians Total Care, Inc.2007-04-04Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralRebel Distributors Corp2009-12-09Not applicableUs
Fexofenadine Hydrochloridetablet60 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2009-12-09Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralbryant ranch prepack2006-04-12Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralPhysicians Total Care, Inc.2006-08-07Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAphena Pharma Solutions Tennessee, Inc.2010-07-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-06-07Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralbryant ranch prepack2006-04-12Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine Hydrochloridetablet, film coated30 mg/1oralPhysicians Total Care, Inc.2005-11-09Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Allergytablet180 mg/1oralLIVE BETTER (The Great Atlantic & Pacific Tea Company)2013-03-20Not applicableUs
7 Select Allergy Relieftablet, film coated180 mg/1oral7 Eleven2014-04-17Not applicableUs
Allegra 12 Hourtablet60 mgoralSanofi Aventis Canada Inc1997-07-10Not applicableCanada
Allegra 24 Hour (120mg)tablet120 mgoralSanofi Aventis Canada Inc2001-01-09Not applicableCanada
Allegra Allergytablet, film coated180 mg/1oralChattem, Inc.2011-03-03Not applicableUs
Allegra Allergytablet180 mg/1oralLil' Drug Store Products, Inc2014-09-01Not applicableUs
Allegra Allergytablet, film coated180 mg/1oralChattem, Inc.2011-03-03Not applicableUs
Allegra Allergytablet180 mg/1oralNavajo Manufacturing Co., Inc.2015-05-12Not applicableUs
Allegra Allergytablet, coated180 mg/1oralChattem, Inc.2014-12-17Not applicableUs
Allegra Allergytablet, film coated60 mg/1oralChattem, Inc.2011-03-03Not applicableUs
Aller Easetablet, film coated180 mg/1oralMeijer Distribution Inc2011-04-14Not applicableUs
Aller Easetablet, film coated60 mg/1oralMeijer Distribution Inc2011-08-24Not applicableUs
Allergy 24-HRtablet, film coated60 mg/1oralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy 24-HRtablet, film coated180 mg/1oralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy 24-HRtablet, film coated30 mg/1oralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralHy Vee Inc2014-02-12Not applicableUs
Allergy Relieftablet180 mg/1oralWal Mart Stores, Inc.2011-04-13Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralSafeway2015-02-02Not applicableUs
Allergy Relieftablet, film coated60 mg/1oralH E B2011-08-24Not applicableUs
Allergy Relieftablet, film coated60 mg/1oralMeijer Distribution Inc2015-01-30Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralHy Vee Inc2015-03-07Not applicableUs
Allergy Relieftablet, film coated60 mg/1oralKroger Company2013-12-19Not applicableUs
Allergy Relieftablet180 mg/1oralP and L Development of New York Corporation2013-03-28Not applicableUs
Allergy Relieftablet180 mg/1oralSAFEWAY INC2013-04-22Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralWestern Family Foods Inc2014-09-17Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralMeijer Distribution Inc2015-03-02Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralShopko Stores Operating Co., LLC2013-07-08Not applicableUs
Allergy Relieftablet, film coated60 mg/1oralCVS Pharmacy2011-08-31Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralPublix Super Markets Inc2012-01-30Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralKroger Company2011-04-16Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralH E B2011-06-22Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralRite Aid Corporation2011-04-15Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralMeijer Distribution Inc2014-06-27Not applicableUs
Berkley and Jensen Allergy Relieftablet, film coated180 mg/1oralBJWC2011-08-11Not applicableUs
Care One Aller Easetablet, film coated180 mg/1oralAmerican Sales Company2011-04-15Not applicableUs
Childrens Allegra Allergytablet, orally disintegrating30 mg/1oralChattem, Inc.2014-01-02Not applicableUs
Childrens Allegra Allergytablet, orally disintegrating30 mg/1oralChattem, Inc.2011-03-03Not applicableUs
Childrens Allegra Allergysuspension6 mg/mLoralChattem, Inc.2011-03-03Not applicableUs
Childrens Allergysuspension30 mg/5mLoralTopco Associates LLC2016-03-21Not applicableUs
Childrens Allergysuspension30 mg/5mLoralSupervalu Inc2016-03-01Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralRugby Laboratories2014-12-19Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralPreferred Plus (Kinray)2015-03-01Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralMeijer Distribution Inc2014-12-19Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralActavis Pharma, Inc.2014-12-22Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralChain Drug Consortium, LLC2014-12-19Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralRite Aid2014-12-19Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralKroger Company2015-07-01Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralHEB2015-07-01Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralWal Mart Stores, Inc.2015-07-01Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralCVS Pharmacy2014-12-19Not applicableUs
Childrens Wal-fexsuspension30 mg/5mLoralWalgreen Company2014-12-19Not applicableUs
Dg Health Aller Easetablet, film coated180 mg/1oralDolgencorp, LLC2011-06-06Not applicableUs
Equaline Aller Easetablet, film coated180 mg/1oralSupervalu Inc2011-04-14Not applicableUs
Equate Allergy Relieftablet, film coated180 mg/1oralWal Mart Stores Inc2011-04-14Not applicableUs
Exchange Select Aller Easetablet, film coated180 mg/1oralArmy & Air Force Exchange Service2015-12-23Not applicableUs
Exchange Select Allergy Relieftablet, film coated180 mg/1oralArmy & Air Force Exchange Service2011-09-26Not applicableUs
Fexo Fenadinetablet, film coated180 mg/1oralKroger Company2011-04-16Not applicableUs
Fexo Fenadinetablet, film coated180 mg/1oralHy Vee Inc2011-04-17Not applicableUs
Fexo Fenadinetablet, film coated60 mg/1oralKroger Company2011-08-16Not applicableUs
Fexofenadinetablet, film coated180 mg/1oralWockhardt Limited2012-02-08Not applicableUs
Fexofenadinetablet, film coated60 mg/1oralHy Vee Inc2011-10-24Not applicableUs
Fexofenadinetablet, film coated30 mg/1oralWockhardt Limited2012-02-08Not applicableUs
Fexofenadinetablet, film coated180 mg/1oralAmerican Health Packaging2016-02-01Not applicableUs
Fexofenadinetablet, film coated60 mg/1oralWockhardt Limited2012-02-08Not applicableUs
Fexofenadine HCltablet180 mg/1oralValu Merchandisers Company (Best Choice)2012-06-04Not applicableUs
Fexofenadine HCltablet, film coated180 mg/1oralCamber Consumer Care2015-09-16Not applicableUs
Fexofenadine HCltablet, film coated180 mg/1oralCVS Pharmacy2015-09-16Not applicableUs
Fexofenadine HCltablet180 mg/1oralShopko Stores Operating Co., LLC.2012-06-11Not applicableUs
Fexofenadine HCltablet180 mg/1oralPreferred Plus (Kinray)2013-03-31Not applicableUs
Fexofenadine HCltablet180 mg/1oralChain Drug Marketing Association2012-08-27Not applicableUs
Fexofenadine HCltablet, film coated60 mg/1oralScie Gen Pharmaceuticals, Inc.2014-12-26Not applicableUs
Fexofenadine HCltablet180 mg/1oralChain Drug Consortium, LLC2012-06-18Not applicableUs
Fexofenadine HCltablet, film coated180 mg/1oralScie Gen Pharmaceuticals, Inc.2014-12-26Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralSt Marys Medical Park Pharmacy2013-01-10Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMajor Pharmaceuticals2011-04-14Not applicableUs
Fexofenadine Hydrochloridetablet, film coated30 mg/1oralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralChain Drug Consortium, LLC2014-04-01Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralPhysicians Total Care, Inc.2011-07-27Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAurohealth LLC2015-01-15Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMylan Institutional Inc.2012-02-13Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAv Kare, Inc.2015-05-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-04-14Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralREMEDYREPACK INC.2013-05-20Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralWestern Family Foods Inc2011-04-14Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralAurolife Pharma, LLC2015-08-26Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMylan Pharmaceuticals Inc.2011-08-25Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralMajor Pharmaceuticals2012-09-04Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralRebel Distributors Corp2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralWal Mart Stores, Inc2015-09-30Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralCarilion Materials Management2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralDr. Reddy's Laboratories Limited2011-01-03Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMylan Institutional Inc.2011-09-27Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAvera Mc Kennan Hospital2015-03-13Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralGolden State Medical Supply, Inc.2014-03-20Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAurolife Pharma, LLC2014-11-19Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralPerrigo New York Inc2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralDispensing Solutions, Inc.2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMylan Pharmaceuticals Inc.2011-08-25Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralRebel Distributors Corp2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralCarilion Materials Management2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralMeijer Distribution, Inc2014-12-29Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralChain Drug Marketing Associate2014-04-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralFred's2015-01-15Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralGolden State Medical Supply, Inc.2014-03-20Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralSafeway2011-04-15Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralPerrigo New York Inc2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralDispensing Solutions, Inc.2011-04-14Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralProficient Rx LP2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralBlenheim Pharmacal, Inc.2013-11-13Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralAv Kare, Inc.2015-10-16Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAidarex Pharmaceuticals LLC2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralProficient Rx LP2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralAvera Mc Kennan Hospital2015-06-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralDiscount Drug Mart2015-05-06Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralClinical Solutions Wholesale2011-04-22Not applicableUs
Fexofenadine Hydrochloride 180tablet180 mg/1oralKaiser Permanente2012-07-05Not applicableUs
Fexofenodine Hydrochloridetablet, film coated60 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-08-08Not applicableUs
Good Neighbor Pharmacy Allergy Relieftablet, film coated180 mg/1oralAmerisource Bergen2011-06-22Not applicableUs
Good Neighbor Pharmacy Allergy Relieftablet, film coated180 mg/1oralAmerisource Bergen2014-08-15Not applicableUs
Good Sense Aller Easetablet, film coated60 mg/1oralL Perrigo Company2011-09-14Not applicableUs
Good Sense Aller Easetablet, film coated180 mg/1oralL Perrigo Company2011-04-14Not applicableUs
Harris Teeter Allergy Relieftablet, film coated180 mg/1oralHarris Teeter, LLC2015-06-24Not applicableUs
Health Mart Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMc Kesson2012-01-18Not applicableUs
Health Mart Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMc Kesson2012-01-26Not applicableUs
Health Mart Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMc Kesson2014-04-01Not applicableUs
Healthy Accents Aller Ease 24 Hourtablet, film coated180 mg/1oralDZA Brands LLC2011-06-15Not applicableUs
Healthy Accents Allergy Relieftablet, film coated180 mg/1oralDZA Brands LLC2011-06-15Not applicableUs
Kirkland Signature Aller Fextablet, film coated180 mg/1oralCostco Wholesale Company2011-04-23Not applicableUs
Leader Aller Easetablet, film coated180 mg/1oralCardinal Health2014-02-05Not applicableUs
Leader Aller Easetablet, film coated180 mg/1oralCardinal Health2011-05-16Not applicableUs
Members Mark Fexofenadinetablet, film coated180 mg/1oralSam's West Inc2011-04-14Not applicableUs
Mucinex Allergytablet180 mg/1oralReckitt Benckiser LLC2014-01-02Not applicableUs
Preferred Plus Aller Easetablet, film coated180 mg/1oralKinray2014-06-17Not applicableUs
Preferred Plus Allergy Relieftablet, film coated180 mg/1oralKinray2014-09-22Not applicableUs
Rugby Fexofenadine Hydrochloridetablet, film coated180 mg/1oralRugby Laboratories2015-01-28Not applicableUs
Shoprite Aller Easetablet, film coated60 mg/1oralWakefern Food Corporation2013-07-09Not applicableUs
Shoprite Aller Easetablet, film coated180 mg/1oralWakefern Food Corporation2013-07-09Not applicableUs
Signature Care Allergy Relieftablet, film coated180 mg/1oralSafeway2015-08-11Not applicableUs
Smart Sense Allergy Relieftablet, film coated180 mg/1oralKmart Corporation2014-08-21Not applicableUs
Smart Sense Allergy Relieftablet, film coated60 mg/1oralKmart Corporation2011-09-01Not applicableUs
Smart Sense Allergy Relieftablet, film coated180 mg/1oralKmart Corporation2011-06-23Not applicableUs
Sunmark Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMc Kesson2011-04-14Not applicableUs
Sunmark Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMc Kesson2011-09-06Not applicableUs
Topcare Allergy Relieftablet, film coated180 mg/1oralTopco Associates LLC2015-01-07Not applicableUs
Topcare Fexofenadine Hydrochloridetablet, film coated180 mg/1oralTopco Associates LLC2011-04-14Not applicableUs
Topcare Fexofenadine Hydrochloridetablet, film coated60 mg/1oralTopco Associates LLC2011-09-02Not applicableUs
Up and Up Allergy Relieftablet, film coated180 mg/1oralTarget Corporation2011-04-13Not applicableUs
Up and Up Allergy Relieftablet, film coated180 mg/1oralTarget Corporation2015-03-25Not applicableUs
Wal Fextablet, film coated60 mg/1oralWalgreen Company2011-08-22Not applicableUs
Wal Fex 24 Hour Allergytablet, film coated180 mg/1oralWalgreen Company2014-03-06Not applicableUs
Wal Fex Allergytablet, film coated60 mg/1oralWalgreen Company2011-08-22Not applicableUs
Wal Fex Allergytablet, film coated180 mg/1oralWalgreen Company2011-04-14Not applicableUs
Wal-fextablet180 mg/1oralWalgreens Company2011-04-13Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
FastofenNot Available
FexidineNot Available
TelfastNot Available
VifasNot Available
Brand mixtures
NameLabellerIngredients
Allegra D 12 Hour Allergy and CongestionRebel Distributors Corp
Allegra D-12 HourSanofi Aventis U.S. Llc
Allegra--d 24 HourSanofi Aventis U.S. Llc
Allegra-Dbryant ranch prepack
Allegra-D 24 HourSTAT Rx USA LLC
Allegra-D Allergy and CongestionChattem, Inc.
Fexofenadine HCl and Pseudoephedrine HciWalgreens Company
Fexofenadine HCl and Pseudoephedrine HClDr.Reddy's Laboratories Limited
Fexofenadine Hydrochloride and Pseudoephedrine HydrochlorideRebel Distributors Corp
Salts
Name/CASStructureProperties
Fexofenadine hydrochloride
ThumbNot applicableDBSALT001227
Categories
UNIIE6582LOH6V
CAS number83799-24-0
WeightAverage: 501.6564
Monoisotopic: 501.287908741
Chemical FormulaC32H39NO4
InChI KeyInChIKey=RWTNPBWLLIMQHL-UHFFFAOYSA-N
InChI
InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)
IUPAC Name
2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid
SMILES
CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • 2-phenylpropanoic-acid
  • Phenylbutylamine
  • Phenylacetate
  • Phenylpropane
  • Aralkylamine
  • Piperidine
  • Tertiary alcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • Azacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor management of Seasonal allergic rhinitis
PharmacodynamicsFexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential of terfenadine, since it does not block the potassium channel involved in repolarization of cardiac cells.
Mechanism of actionLike other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Fexofenadine exhibits no anticholinergic, antidopaminergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.
Related Articles
Absorption33%
Volume of distributionNot Available
Protein binding60%-70%
Metabolism

Approximately 5% of the total dose is metabolized, by cytochrome P450 3A4 and by intestinal microflora.

Route of eliminationNot Available
Half life14.4 hours
ClearanceNot Available
ToxicitySide effects include dizziness, drowsiness, and dry mouth.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7881
Blood Brain Barrier-0.8574
Caco-2 permeable+0.5
P-glycoprotein substrateSubstrate0.8641
P-glycoprotein inhibitor INon-inhibitor0.6791
P-glycoprotein inhibitor IINon-inhibitor0.8779
Renal organic cation transporterNon-inhibitor0.5166
CYP450 2C9 substrateNon-substrate0.836
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6458
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9162
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8421
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9756
Ames testNon AMES toxic0.9122
CarcinogenicityNon-carcinogens0.9163
BiodegradationNot ready biodegradable0.8428
Rat acute toxicity2.3481 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8469
hERG inhibition (predictor II)Inhibitor0.6258
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Sanofi aventis us llc
  • Barr laboratories inc
  • Dr reddys laboratories ltd
  • Mylan pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Sanofi-Aventis
Packagers
Dosage forms
FormRouteStrength
Suspensionoral6 mg/mL
Tabletoral60 mg
Tabletoral120 mg
Tablet, coatedoral180 mg/1
Tablet, extended releaseoral
Tablet, film coatedoral
Tablet (extended-release)oral
Tablet, orally disintegratingoral30 mg/1
Suspensionoral30 mg/5mL
Tabletoral60 mg/1
Tablet, film coatedoral30 mg/1
Tabletoral180 mg/1
Tablet, film coated, extended releaseoral
Tablet, film coatedoral180 mg/1
Tablet, film coatedoral60 mg/1
Prices
Unit descriptionCostUnit
Allegra ODT 60 30 mg Dispersible Tablet Box126.0USD box
Allegra-D 24 Hour 180-240 mg 24 Hour tablet5.01USD tablet
Allegra-d 24 hour tablet4.98USD tablet
Allegra 180 mg tablet2.89USD tablet
Allegra-D 12 Hour 60-120 mg 12 Hour tablet2.72USD tablet
Allegra-d 12 hour tablet2.49USD tablet
Fexofenadine hcl 180 mg tablet2.47USD tablet
Allegra odt 30 mg tablet1.98USD tablet
Allegra 60 mg tablet1.64USD tablet
Fexofenadine hcl 60 mg tablet1.43USD tablet
Allegra 30 mg tablet0.81USD tablet
Fexofenadine hcl 30 mg tablet0.71USD tablet
Allegra 30 mg/5ml Suspension0.25USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2134211 No1999-06-292013-04-06Canada
CA2301267 No2004-07-132018-07-21Canada
US5178878 No1993-01-122010-01-12Us
US5738872 Yes1995-08-282015-08-28Us
US5855912 Yes1995-08-282015-08-28Us
US5932247 Yes1995-08-282015-08-28Us
US6037353 Yes1997-09-142017-09-14Us
US6039974 No1998-07-312018-07-31Us
US6113942 Yes1995-08-282015-08-28Us
US6613357 No2000-12-252020-12-25Us
US6723348 No2001-11-262021-11-26Us
US8933097 No2012-08-162032-08-16Us
USRE39069 No1998-05-292018-05-29Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point142.5 °CPhysProp
water solubilitySlightly solubleNot Available
logP5.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00266 mg/mLALOGPS
logP5.02ALOGPS
logP2.94ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)4.04ChemAxon
pKa (Strongest Basic)9.01ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area81 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity147.98 m3·mol-1ChemAxon
Polarizability57.42 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Federico Milla, “Processes for the production of fexofenadine.” U.S. Patent US20030166682, issued September 04, 2003.

US20030166682
General References
  1. Smith SM, Gums JG: Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):813-22. doi: 10.1517/17425250903044967. [PubMed:19545214 ]
  2. Bachert C: A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther. 2009 May;31(5):921-44. doi: 10.1016/j.clinthera.2009.05.017. [PubMed:19539095 ]
  3. Markham A, Wagstaff AJ: Fexofenadine. Drugs. 1998 Feb;55(2):269-74; discussion 275-6. [PubMed:9506246 ]
  4. Golightly LK, Greos LS: Second-generation antihistamines: actions and efficacy in the management of allergic disorders. Drugs. 2005;65(3):341-84. [PubMed:15669879 ]
  5. Molimard M, Diquet B, Benedetti MS: Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. Fundam Clin Pharmacol. 2004 Aug;18(4):399-411. [PubMed:15312146 ]
External Links
ATC CodesR06AX26
AHFS Codes
  • 04:08.00
PDB EntriesNot Available
FDA labelDownload (43.7 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Fexofenadine.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Fexofenadine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Fexofenadine.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Fexofenadine.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fexofenadine.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fexofenadine.
AcetaminophenThe serum concentration of Fexofenadine can be increased when it is combined with Acetaminophen.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Fexofenadine.
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Fexofenadine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Fexofenadine.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Fexofenadine.
AlbendazoleThe serum concentration of Fexofenadine can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Fexofenadine can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Fexofenadine.
AlectinibThe serum concentration of Fexofenadine can be increased when it is combined with Alectinib.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Fexofenadine.
AlfentanilThe serum concentration of Fexofenadine can be increased when it is combined with Alfentanil.
AlfentanilThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Alfentanil.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Fexofenadine.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Fexofenadine.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fexofenadine.
Aluminum hydroxideThe serum concentration of Fexofenadine can be decreased when it is combined with Aluminum hydroxide.
Aluminum phosphateThe serum concentration of Fexofenadine can be decreased when it is combined with Aluminum phosphate.
AmantadineThe serum concentration of Fexofenadine can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Fexofenadine.
Aminohippuric acidThe serum concentration of Fexofenadine can be increased when it is combined with Aminohippuric acid.
AmiodaroneThe serum concentration of Fexofenadine can be decreased when it is combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Fexofenadine.
AmitriptylineThe serum concentration of Fexofenadine can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Fexofenadine can be increased when it is combined with Amlodipine.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Fexofenadine.
AmoxapineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Fexofenadine.
AmphetamineAmphetamine may decrease the sedative activities of Fexofenadine.
AmprenavirThe serum concentration of Fexofenadine can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Fexofenadine can be increased when it is combined with Amsacrine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fexofenadine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fexofenadine.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Fexofenadine.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Fexofenadine.
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Fexofenadine.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Fexofenadine.
AstemizoleThe serum concentration of Fexofenadine can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Fexofenadine.
AtenololThe serum concentration of Fexofenadine can be increased when it is combined with Atenolol.
AtorvastatinThe serum concentration of Fexofenadine can be increased when it is combined with Atorvastatin.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Fexofenadine.
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Fexofenadine.
AzelastineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe serum concentration of Fexofenadine can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Fexofenadine can be increased when it is combined with Azithromycin.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Fexofenadine.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Fexofenadine.
BenzocaineThe serum concentration of Fexofenadine can be increased when it is combined with Benzocaine.
BenzocaineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Benzocaine.
BenzphetamineBenzphetamine may decrease the sedative activities of Fexofenadine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Fexofenadine.
Benzylpenicilloyl PolylysineFexofenadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BepridilThe serum concentration of Fexofenadine can be increased when it is combined with Bepridil.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Fexofenadine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Fexofenadine.
BiperidenThe serum concentration of Fexofenadine can be increased when it is combined with Biperiden.
Bismuth SubcitrateThe serum concentration of Fexofenadine can be decreased when it is combined with Bismuth Subcitrate.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Fexofenadine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fexofenadine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Fexofenadine.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
BrimonidineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Fexofenadine.
BromocriptineThe serum concentration of Fexofenadine can be increased when it is combined with Bromocriptine.
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Fexofenadine.
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Fexofenadine.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fexofenadine.
BuprenorphineThe serum concentration of Fexofenadine can be increased when it is combined with Buprenorphine.
BuprenorphineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Buprenorphine.
BuspironeThe serum concentration of Fexofenadine can be increased when it is combined with Buspirone.
BuspironeThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Buspirone.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Fexofenadine.
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Fexofenadine.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Fexofenadine.
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Fexofenadine.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Fexofenadine.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Fexofenadine.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Fexofenadine.
CaffeineThe serum concentration of Fexofenadine can be increased when it is combined with Caffeine.
Calcium carbonateThe serum concentration of Fexofenadine can be decreased when it is combined with Calcium carbonate.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Fexofenadine.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Fexofenadine.
CandesartanThe serum concentration of Fexofenadine can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Fexofenadine can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Fexofenadine can be decreased when it is combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Fexofenadine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Fexofenadine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fexofenadine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Fexofenadine.
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Fexofenadine.
CarvedilolThe serum concentration of Fexofenadine can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Fexofenadine can be increased when it is combined with Caspofungin.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Fexofenadine.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Fexofenadine.
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Fexofenadine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fexofenadine.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fexofenadine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fexofenadine.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Fexofenadine.
ChloroquineThe serum concentration of Fexofenadine can be increased when it is combined with Chloroquine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Chlorphenamine.
ChlorphentermineChlorphentermine may decrease the sedative activities of Fexofenadine.
ChlorpromazineThe serum concentration of Fexofenadine can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Fexofenadine can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Fexofenadine can be increased when it is combined with Chlorprothixene.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Fexofenadine.
CholesterolThe serum concentration of Fexofenadine can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Fexofenadine can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Fexofenadine can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Fexofenadine can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Fexofenadine.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Fexofenadine.
CiprofloxacinThe serum concentration of Fexofenadine can be increased when it is combined with Ciprofloxacin.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Fexofenadine.
CitalopramThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Citalopram.
CitalopramThe serum concentration of Fexofenadine can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Fexofenadine can be increased when it is combined with Clarithromycin.
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Fexofenadine.
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Fexofenadine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Fexofenadine.
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Fexofenadine.
ClofazimineThe serum concentration of Fexofenadine can be increased when it is combined with Clofazimine.
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Fexofenadine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Fexofenadine.
ClomipramineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Clomipramine.
ClomipramineThe serum concentration of Fexofenadine can be increased when it is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Clonazepam.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Fexofenadine.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Fexofenadine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Fexofenadine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Fexofenadine.
ClotrimazoleThe serum concentration of Fexofenadine can be decreased when it is combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Fexofenadine.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Fexofenadine.
CobicistatThe serum concentration of Fexofenadine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Fexofenadine.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Fexofenadine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Fexofenadine.
ColchicineThe serum concentration of Fexofenadine can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Fexofenadine can be increased when it is combined with Colforsin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Fexofenadine.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Fexofenadine.
CyclizineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fexofenadine.
CyclophosphamideThe serum concentration of Fexofenadine can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Fexofenadine can be decreased when it is combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Fexofenadine.
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Fexofenadine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Fexofenadine.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Fexofenadine.
DaclatasvirThe serum concentration of Fexofenadine can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Fexofenadine can be increased when it is combined with Dactinomycin.
DantroleneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Dantrolene.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Fexofenadine.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Fexofenadine.
DapoxetineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Dapoxetine.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Fexofenadine.
DaunorubicinThe serum concentration of Fexofenadine can be decreased when it is combined with Daunorubicin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Fexofenadine.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Fexofenadine.
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Fexofenadine.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Fexofenadine.
DesipramineThe serum concentration of Fexofenadine can be increased when it is combined with Desipramine.
DesipramineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Desipramine.
DesloratadineThe serum concentration of Fexofenadine can be increased when it is combined with Desloratadine.
DesloratadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Fexofenadine.
DexamethasoneThe serum concentration of Fexofenadine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Fexofenadine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Fexofenadine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Fexofenadine.
DextroamphetamineDextroamphetamine may decrease the sedative activities of Fexofenadine.
DextromethorphanThe serum concentration of Fexofenadine can be increased when it is combined with Dextromethorphan.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Fexofenadine.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fexofenadine.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Fexofenadine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fexofenadine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Fexofenadine.
DiclofenacThe serum concentration of Fexofenadine can be increased when it is combined with Diclofenac.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Fexofenadine.
DifenoxinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Difenoxin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Fexofenadine.
DigoxinThe serum concentration of Fexofenadine can be decreased when it is combined with Digoxin.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Fexofenadine.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Fexofenadine.
DihydroergotamineThe serum concentration of Fexofenadine can be increased when it is combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Fexofenadine.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Fexofenadine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fexofenadine.
DiltiazemThe serum concentration of Fexofenadine can be increased when it is combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fexofenadine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Fexofenadine.
DipyridamoleThe serum concentration of Fexofenadine can be increased when it is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Fexofenadine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fexofenadine.
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Fexofenadine.
DoxazosinThe serum concentration of Fexofenadine can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Fexofenadine can be increased when it is combined with Doxepin.
DoxepinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Doxepin.
DoxorubicinThe serum concentration of Fexofenadine can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fexofenadine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
DoxylamineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Fexofenadine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
DronedaroneThe serum concentration of Fexofenadine can be increased when it is combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Fexofenadine.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Fexofenadine.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Fexofenadine.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Fexofenadine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Fexofenadine.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Fexofenadine.
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Fexofenadine.
ElbasvirThe serum concentration of Fexofenadine can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fexofenadine.
EnalaprilThe serum concentration of Fexofenadine can be increased when it is combined with Enalapril.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Fexofenadine.
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Fexofenadine.
EnzalutamideThe serum concentration of Fexofenadine can be increased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Fexofenadine.
ErgonovineThe serum concentration of Fexofenadine can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Fexofenadine can be increased when it is combined with Ergotamine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Fexofenadine.
ErythromycinThe serum concentration of Fexofenadine can be increased when it is combined with Erythromycin.
EscitalopramThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Fexofenadine.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Fexofenadine.
EstramustineThe serum concentration of Fexofenadine can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Fexofenadine can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Fexofenadine.
EstroneThe serum concentration of Fexofenadine can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Fexofenadine.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Fexofenadine.
EthanolFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Fexofenadine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Fexofenadine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fexofenadine.
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Fexofenadine.
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Fexofenadine.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Fexofenadine.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Fexofenadine.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Fexofenadine.
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Fexofenadine.
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Fexofenadine.
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Fexofenadine.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Fexofenadine.
EtoperidoneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Etoperidone.
EtoposideThe serum concentration of Fexofenadine can be increased when it is combined with Etoposide.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Fexofenadine.
EtravirineThe serum concentration of Fexofenadine can be increased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fexofenadine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Fexofenadine.
EzogabineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Fexofenadine.
FelodipineThe serum concentration of Fexofenadine can be increased when it is combined with Felodipine.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Fexofenadine.
FenfluramineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Fenfluramine.
FentanylThe serum concentration of Fexofenadine can be increased when it is combined with Fentanyl.
FentanylThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Fentanyl.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Flibanserin.
FluconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Fexofenadine.
FlunarizineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Fexofenadine.
FluoxetineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Fluoxetine.
FluoxetineThe serum concentration of Fexofenadine can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Fexofenadine can be increased when it is combined with Flupentixol.
FlupentixolThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Flupentixol.
FluphenazineThe serum concentration of Fexofenadine can be increased when it is combined with Fluphenazine.
FluphenazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Fluphenazine.
FlurazepamThe serum concentration of Fexofenadine can be increased when it is combined with Flurazepam.
FlurazepamThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Fexofenadine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Fexofenadine.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Fexofenadine.
FluvoxamineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Fluvoxamine.
FluvoxamineThe serum concentration of Fexofenadine can be increased when it is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Fexofenadine.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Fexofenadine.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Fexofenadine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Fexofenadine.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Fexofenadine.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Fexofenadine.
GenisteinThe serum concentration of Fexofenadine can be increased when it is combined with Genistein.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fexofenadine.
GlyburideThe serum concentration of Fexofenadine can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Fexofenadine can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Fexofenadine can be increased when it is combined with Gramicidin D.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Fexofenadine.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Fexofenadine.
GuanfacineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Fexofenadine.
HaloperidolThe serum concentration of Fexofenadine can be increased when it is combined with Haloperidol.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Fexofenadine.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Fexofenadine.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Fexofenadine.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Fexofenadine.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Fexofenadine.
HydrocortisoneThe serum concentration of Fexofenadine can be increased when it is combined with Hydrocortisone.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Fexofenadine.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Fexofenadine.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
HydroxyzineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Hydroxyzine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Fexofenadine.
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Fexofenadine.
IloperidoneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Iloperidone.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fexofenadine.
ImipramineThe serum concentration of Fexofenadine can be increased when it is combined with Imipramine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Fexofenadine.
IndalpineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Indalpine.
IndinavirThe serum concentration of Fexofenadine can be decreased when it is combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Fexofenadine.
IndomethacinThe serum concentration of Fexofenadine can be increased when it is combined with Indomethacin.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Fexofenadine.
IsavuconazoniumThe serum concentration of Fexofenadine can be increased when it is combined with Isavuconazonium.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Fexofenadine.
ItraconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Fexofenadine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Fexofenadine can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Fexofenadine can be increased when it is combined with Ketamine.
KetamineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Fexofenadine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Fexofenadine.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Fexofenadine.
KetoconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Fexofenadine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Fexofenadine.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fexofenadine.
LansoprazoleThe serum concentration of Fexofenadine can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Fexofenadine can be increased when it is combined with Lapatinib.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Fexofenadine.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Fexofenadine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Fexofenadine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Fexofenadine.
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Fexofenadine.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Fexofenadine.
LevocabastineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Levodopa.
LevofloxacinThe serum concentration of Fexofenadine can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Fexofenadine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Fexofenadine.
LevothyroxineThe serum concentration of Fexofenadine can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Fexofenadine can be increased when it is combined with Lidocaine.
LidocaineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Fexofenadine.
LiothyronineThe serum concentration of Fexofenadine can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Fexofenadine can be decreased when it is combined with Liotrix.
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Fexofenadine.
LisinoprilThe serum concentration of Fexofenadine can be increased when it is combined with Lisinopril.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Fexofenadine.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Fexofenadine.
LomitapideThe serum concentration of Fexofenadine can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Fexofenadine can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Fexofenadine can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Fexofenadine can be increased when it is combined with Loratadine.
LoratadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fexofenadine.
LosartanThe serum concentration of Fexofenadine can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Fexofenadine can be increased when it is combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Fexofenadine.
Lu AA21004The risk or severity of adverse effects can be increased when Fexofenadine is combined with Lu AA21004.
LumacaftorThe serum concentration of Fexofenadine can be decreased when it is combined with Lumacaftor.
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Fexofenadine.
MagaldrateThe serum concentration of Fexofenadine can be decreased when it is combined with Magaldrate.
Magnesium carbonateThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium carbonate.
Magnesium hydroxideThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium hydroxide.
Magnesium oxideThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium oxide.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Magnesium Sulfate.
Magnesium TrisilicateThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium Trisilicate.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Fexofenadine.
MaprotilineThe serum concentration of Fexofenadine can be increased when it is combined with Maprotiline.
MaprotilineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Maprotiline.
MebendazoleThe serum concentration of Fexofenadine can be increased when it is combined with Mebendazole.
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fexofenadine.
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Fexofenadine.
MefloquineThe serum concentration of Fexofenadine can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Fexofenadine can be increased when it is combined with Megestrol acetate.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Fexofenadine.
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Fexofenadine.
MephentermineMephentermine may decrease the sedative activities of Fexofenadine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Fexofenadine.
MeprobamateThe serum concentration of Fexofenadine can be increased when it is combined with Meprobamate.
MeprobamateThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Meprobamate.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Fexofenadine.
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Fexofenadine.
MethadoneThe serum concentration of Fexofenadine can be increased when it is combined with Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Methadone.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fexofenadine.
MethamphetamineMethamphetamine may decrease the sedative activities of Fexofenadine.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Fexofenadine.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Fexofenadine.
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Fexofenadine.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Fexofenadine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Fexofenadine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Fexofenadine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Fexofenadine.
MethsuximideThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Fexofenadine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Fexofenadine.
MetoprololThe serum concentration of Fexofenadine can be increased when it is combined with Metoprolol.
MetyrosineFexofenadine may increase the sedative activities of Metyrosine.
MibefradilThe serum concentration of Fexofenadine can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Fexofenadine can be decreased when it is combined with Midazolam.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Fexofenadine.
MifepristoneThe serum concentration of Fexofenadine can be decreased when it is combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Fexofenadine.
MirtazapineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Fexofenadine.
MitomycinThe serum concentration of Fexofenadine can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Fexofenadine can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Fexofenadine.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Fexofenadine.
MorphineThe serum concentration of Fexofenadine can be increased when it is combined with Morphine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Fexofenadine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
NabiloneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Nabilone.
NadololThe serum concentration of Nadolol can be increased when it is combined with Fexofenadine.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Fexofenadine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fexofenadine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Fexofenadine.
NaltrexoneThe serum concentration of Fexofenadine can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Fexofenadine can be increased when it is combined with Naringenin.
NefazodoneThe serum concentration of Fexofenadine can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Fexofenadine can be decreased when it is combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Fexofenadine.
NeostigmineThe serum concentration of Fexofenadine can be increased when it is combined with Neostigmine.
NicardipineThe serum concentration of Fexofenadine can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Fexofenadine can be decreased when it is combined with Nifedipine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Fexofenadine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Fexofenadine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Fexofenadine.
NisoldipineThe serum concentration of Fexofenadine can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Fexofenadine can be increased when it is combined with Nitrazepam.
NitrazepamThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Nitrazepam.
NitrendipineThe serum concentration of Fexofenadine can be increased when it is combined with Nitrendipine.
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fexofenadine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Fexofenadine.
NorethisteroneThe serum concentration of Fexofenadine can be decreased when it is combined with Norethisterone.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Fexofenadine.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Fexofenadine.
OlanzapineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Fexofenadine.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Fexofenadine.
OmeprazoleThe serum concentration of Fexofenadine can be increased when it is combined with Omeprazole.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Fexofenadine.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Fexofenadine.
OrphenadrineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Fexofenadine.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Fexofenadine.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Fexofenadine.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Fexofenadine.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Fexofenadine.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Fexofenadine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fexofenadine.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Fexofenadine.
P-NitrophenolThe serum concentration of Fexofenadine can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Fexofenadine can be increased when it is combined with Paclitaxel.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Fexofenadine.
Palmitic AcidThe serum concentration of Fexofenadine can be increased when it is combined with Palmitic Acid.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Fexofenadine.
PantoprazoleThe serum concentration of Fexofenadine can be increased when it is combined with Pantoprazole.
ParaldehydeFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Fexofenadine.
ParoxetineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Paroxetine.
ParoxetineThe serum concentration of Fexofenadine can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Fexofenadine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Fexofenadine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Fexofenadine.
PerampanelThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Perampanel.
PerindoprilThe serum concentration of Fexofenadine can be increased when it is combined with Perindopril.
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Fexofenadine.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Fexofenadine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Fexofenadine.
PhenobarbitalThe serum concentration of Fexofenadine can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Fexofenadine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Fexofenadine.
PhenterminePhentermine may decrease the sedative activities of Fexofenadine.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Fexofenadine.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Fexofenadine.
PimozideThe serum concentration of Fexofenadine can be increased when it is combined with Pimozide.
PimozideThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Pimozide.
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Fexofenadine.
PipotiazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Pipotiazine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Fexofenadine.
PizotifenThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Pizotifen.
Platelet Activating FactorThe serum concentration of Fexofenadine can be decreased when it is combined with Platelet Activating Factor.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Fexofenadine.
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Fexofenadine.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Fexofenadine.
PosaconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Posaconazole.
PramipexoleFexofenadine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Fexofenadine.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Fexofenadine.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Fexofenadine.
PrazosinThe serum concentration of Fexofenadine can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Fexofenadine.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Fexofenadine.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fexofenadine.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fexofenadine.
PrimidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Fexofenadine.
ProbenecidThe serum concentration of Fexofenadine can be increased when it is combined with Probenecid.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Fexofenadine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Fexofenadine.
ProgesteroneThe serum concentration of Fexofenadine can be decreased when it is combined with Progesterone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Fexofenadine.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Fexofenadine.
PromethazineThe serum concentration of Fexofenadine can be increased when it is combined with Promethazine.
PromethazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Promethazine.
PropafenoneThe serum concentration of Fexofenadine can be increased when it is combined with Propafenone.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fexofenadine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Fexofenadine.
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Fexofenadine.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Fexofenadine.
ProtriptylineThe serum concentration of Fexofenadine can be increased when it is combined with Protriptyline.
ProtriptylineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Fexofenadine.
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Fexofenadine.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Fexofenadine.
QuercetinThe serum concentration of Fexofenadine can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Fexofenadine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Fexofenadine.
QuinacrineThe serum concentration of Fexofenadine can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Fexofenadine can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Fexofenadine can be increased when it is combined with Quinine.
RamelteonThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ramelteon.
RanitidineThe serum concentration of Fexofenadine can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fexofenadine.
ReboxetineThe serum concentration of Fexofenadine can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Fexofenadine can be increased when it is combined with Regorafenib.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Fexofenadine.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Fexofenadine.
ReserpineThe serum concentration of Fexofenadine can be decreased when it is combined with Reserpine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Fexofenadine.
RifampicinThe serum concentration of Fexofenadine can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Fexofenadine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Fexofenadine.
RilpivirineThe serum concentration of Fexofenadine can be increased when it is combined with Rilpivirine.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Fexofenadine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Fexofenadine.
RitonavirThe serum concentration of Fexofenadine can be decreased when it is combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Fexofenadine.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Fexofenadine.
RolapitantThe serum concentration of Fexofenadine can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Fexofenadine.
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Fexofenadine.
RopiniroleFexofenadine may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Fexofenadine.
RotigotineFexofenadine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Fexofenadine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Fexofenadine.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Fexofenadine.
SaquinavirThe serum concentration of Fexofenadine can be decreased when it is combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Fexofenadine.
ScopolamineThe serum concentration of Fexofenadine can be increased when it is combined with Scopolamine.
ScopolamineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Fexofenadine.
SelegilineThe serum concentration of Fexofenadine can be increased when it is combined with Selegiline.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Fexofenadine.
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Fexofenadine.
SertralineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Sertraline.
SertralineThe serum concentration of Fexofenadine can be increased when it is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Fexofenadine.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Fexofenadine.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fexofenadine.
SimvastatinThe serum concentration of Fexofenadine can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Fexofenadine can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Fexofenadine.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Fexofenadine.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Fexofenadine.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Fexofenadine.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Fexofenadine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Fexofenadine.
SpironolactoneThe serum concentration of Fexofenadine can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Fexofenadine can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Fexofenadine can be increased when it is combined with Staurosporine.
StiripentolThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Stiripentol.
StreptozocinThe serum concentration of Fexofenadine can be decreased when it is combined with Streptozocin.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Fexofenadine.
SulfinpyrazoneThe serum concentration of Fexofenadine can be increased when it is combined with Sulfinpyrazone.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Fexofenadine.
SumatriptanThe serum concentration of Fexofenadine can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Fexofenadine can be increased when it is combined with Sunitinib.
SuvorexantThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Suvorexant.
TacrineThe serum concentration of Fexofenadine can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Fexofenadine can be decreased when it is combined with Tacrolimus.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Fexofenadine.
TamoxifenThe serum concentration of Fexofenadine can be decreased when it is combined with Tamoxifen.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Fexofenadine.
TapentadolThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Tasimelteon.
Taurocholic AcidThe serum concentration of Fexofenadine can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fexofenadine.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Fexofenadine.
TelmisartanThe serum concentration of Fexofenadine can be increased when it is combined with Telmisartan.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Fexofenadine.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Fexofenadine.
TerazosinThe serum concentration of Fexofenadine can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Fexofenadine can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Fexofenadine can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Fexofenadine can be increased when it is combined with Testosterone.
TetrabenazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Fexofenadine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Fexofenadine.
ThalidomideFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Fexofenadine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Fexofenadine.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Fexofenadine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Fexofenadine.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Fexofenadine.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Fexofenadine.
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Fexofenadine.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Fexofenadine.
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Fexofenadine.
TimololThe serum concentration of Timolol can be increased when it is combined with Fexofenadine.
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Fexofenadine.
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Fexofenadine.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fexofenadine.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Fexofenadine.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Fexofenadine.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Fexofenadine.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Fexofenadine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Fexofenadine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Fexofenadine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Fexofenadine.
TrazodoneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Trazodone.
TrazodoneThe serum concentration of Fexofenadine can be decreased when it is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Fexofenadine.
TrifluoperazineThe serum concentration of Fexofenadine can be increased when it is combined with Trifluoperazine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Fexofenadine can be increased when it is combined with Triflupromazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Triflupromazine.
TrimethoprimThe serum concentration of Fexofenadine can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Fexofenadine can be increased when it is combined with Trimipramine.
TrimipramineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Fexofenadine.
TroleandomycinThe serum concentration of Fexofenadine can be increased when it is combined with Troleandomycin.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fexofenadine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Fexofenadine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Fexofenadine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Fexofenadine.
VenlafaxineThe serum concentration of Fexofenadine can be increased when it is combined with Venlafaxine.
VerapamilThe bioavailability of Fexofenadine can be increased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Fexofenadine.
VigabatrinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Vilazodone.
VinblastineThe serum concentration of Fexofenadine can be decreased when it is combined with Vinblastine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Fexofenadine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Fexofenadine.
VincristineThe serum concentration of Fexofenadine can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Fexofenadine can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Fexofenadine.
VortioxetineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Fexofenadine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Fexofenadine.
ZiconotideThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ziconotide.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Fexofenadine.
ZimelidineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Zimelidine.
ZimelidineThe serum concentration of Fexofenadine can be increased when it is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Fexofenadine.
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Fexofenadine.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Fexofenadine.
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Fexofenadine.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Fexofenadine.
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Fexofenadine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Fexofenadine.
Food Interactions
  • Grapefruit and grapefruit juice should be avoided throughout treatment as grapefruit can significantly decrease serum levels of this product.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Amon U, Amon S, Gibbs BF: In vitro studies with fexofenadine, a new nonsedating histamine H1 receptor antagonist, on isolated human basophils. Inflamm Res. 2000 Apr;49 Suppl 1:S13-4. [PubMed:10864400 ]
  3. Abbas MN, Abdel Fattah AA, Zahran E: A novel membrane sensor for histamine H1-receptor antagonist "fexofenadine". Anal Sci. 2004 Aug;20(8):1137-42. [PubMed:15352500 ]
  4. Grzelewska-Rzymowska I, Kroczynska-Bednarek J, Pietrzkowicz M: [Effect of fexofenadine--selective antagonist of histamine receptor (H1) on histamine-induced bronchoconstriction]. Pol Merkur Lekarski. 2003 Jan;14(79):43-6. [PubMed:12712828 ]
  5. Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, Aoki M, Funaki Y, Itoh M, Iwata R, Wong DF, Yanai K: Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol. 2004 Aug;44(8):890-900. [PubMed:15286093 ]
  6. Cavero I, Mestre M, Guillon JM, Heuillet E, Roach AG: Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans? Drug Saf. 1999;21 Suppl 1:19-31; discussion 81-7. [PubMed:10597865 ]
  7. Devillier P, Roche N, Faisy C: Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. Clin Pharmacokinet. 2008;47(4):217-30. [PubMed:18336052 ]
  8. Dhanya NB, Thasleem Z, Rai R, Srinivas CR: Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test. Indian J Dermatol Venereol Leprol. 2008 Jul-Aug;74(4):361-3. [PubMed:18797058 ]
  9. Smith SM, Gums JG: Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):813-22. doi: 10.1517/17425250903044967. [PubMed:19545214 ]
  10. Markham A, Wagstaff AJ: Fexofenadine. Drugs. 1998 Feb;55(2):269-74; discussion 275-6. [PubMed:9506246 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
  2. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ: Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr;16(4):478-85. [PubMed:10227700 ]
  3. Petri N, Tannergren C, Rungstad D, Lennernas H: Transport characteristics of fexofenadine in the Caco-2 cell model. Pharm Res. 2004 Aug;21(8):1398-404. [PubMed:15359574 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. [PubMed:14610227 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y: Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos. 2005 Oct;33(10):1477-81. Epub 2005 Jul 13. [PubMed:16014768 ]
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Drug created on June 13, 2005 07:24 / Updated on September 26, 2016 03:28