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Identification
NameFexofenadine
Accession NumberDB00950  (APRD00349)
TypeSmall Molecule
GroupsApproved
Description

Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.

Structure
Thumb
Synonyms
4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid
Carboxyterfenadine
Fexofenadine
Terfenadine acid metabolite
Terfenadine carboxylate
Terfenadine-COOH
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Allegrasuspension6 mg/mLoralSanofi Aventis U.S. Llc2006-10-16Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-02-25Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-02-25Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralbryant ranch prepack2006-04-12Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralDIRECT RX2015-12-03Not applicableUs
Fexofenadine Hydrochloridetablet60 mg/1oralREMEDYREPACK INC.2011-08-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralPd Rx Pharmaceuticals, Inc.2010-05-21Not applicableUs
Fexofenadine Hydrochloridetablet60 mg/1oralREMEDYREPACK INC.2011-08-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated30 mg/1oralPhysicians Total Care, Inc.2005-11-09Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAphena Pharma Solutions Tennessee, Inc.2010-07-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralPhysicians Total Care, Inc.2006-08-07Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralRebel Distributors Corp2009-12-09Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralPhysicians Total Care, Inc.2007-04-04Not applicableUs
Fexofenadine Hydrochloridetablet60 mg/1oralRebel Distributors Corp2009-12-09Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-06-07Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine Hydrochloridetablet60 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2009-12-09Not applicableUs
Fexofenadine Hydrochloridetablet, film coated30 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralbryant ranch prepack2006-04-12Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Allergytablet180 mg/1oralLIVE BETTER (The Great Atlantic & Pacific Tea Company)2013-03-20Not applicableUs
7 Select Allergy Relieftablet, film coated180 mg/1oral7 Eleven2014-04-17Not applicableUs
Allegra 12 Hourtablet60 mgoralSanofi Aventis Canada Inc1997-07-10Not applicableCanada
Allegra 24 Hour (120mg)tablet120 mgoralSanofi Aventis Canada Inc2001-01-09Not applicableCanada
Allegra Allergytablet, film coated60 mg/1oralChattem, Inc.2011-03-03Not applicableUs
Allegra Allergytablet180 mg/1oralNavajo Manufacturing Co., Inc.2015-05-12Not applicableUs
Allegra Allergytablet, coated180 mg/1oralChattem, Inc.2014-12-17Not applicableUs
Allegra Allergytablet180 mg/1oralLil' Drug Store Products, Inc2014-09-01Not applicableUs
Allegra Allergytablet, film coated180 mg/1oralChattem, Inc.2011-03-03Not applicableUs
Allegra Allergytablet, film coated180 mg/1oralChattem, Inc.2011-03-03Not applicableUs
Aller Easetablet, film coated180 mg/1oralMeijer Distribution Inc2011-04-14Not applicableUs
Aller Easetablet, film coated60 mg/1oralMeijer Distribution Inc2011-08-24Not applicableUs
Allergy 24-HRtablet, film coated180 mg/1oralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy 24-HRtablet, film coated60 mg/1oralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy 24-HRtablet, film coated30 mg/1oralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralHy Vee Inc2014-02-12Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralMeijer Distribution Inc2014-06-27Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralHy Vee Inc2015-03-07Not applicableUs
Allergy Relieftablet, film coated60 mg/1oralH E B2011-08-24Not applicableUs
Allergy Relieftablet180 mg/1oralWal Mart Stores, Inc.2011-04-13Not applicableUs
Allergy Relieftablet, film coated60 mg/1oralKroger Company2013-12-19Not applicableUs
Allergy Relieftablet, film coated60 mg/1oralCVS Pharmacy2011-08-31Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralShopko Stores Operating Co., LLC2013-07-08Not applicableUs
Allergy Relieftablet180 mg/1oralP and L Development of New York Corporation2013-03-28Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralRite Aid Corporation2011-04-15Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralKroger Company2011-04-16Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralMeijer Distribution Inc2015-03-02Not applicableUs
Allergy Relieftablet180 mg/1oralSAFEWAY INC2013-04-22Not applicableUs
Allergy Relieftablet, film coated60 mg/1oralMeijer Distribution Inc2015-01-30Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralWestern Family Foods Inc2014-09-17Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralPublix Super Markets Inc2012-01-30Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralSafeway2015-02-02Not applicableUs
Allergy Relieftablet, film coated180 mg/1oralH E B2011-06-22Not applicableUs
Berkley and Jensen Allergy Relieftablet, film coated180 mg/1oralBJWC2011-08-11Not applicableUs
Care One Aller Easetablet, film coated180 mg/1oralAmerican Sales Company2011-04-15Not applicableUs
Childrens Allegra Allergytablet, orally disintegrating30 mg/1oralChattem, Inc.2011-03-03Not applicableUs
Childrens Allegra Allergysuspension6 mg/mLoralChattem, Inc.2011-03-03Not applicableUs
Childrens Allegra Allergytablet, orally disintegrating30 mg/1oralChattem, Inc.2014-01-02Not applicableUs
Childrens Allergysuspension30 mg/5mLoralSupervalu Inc2016-03-01Not applicableUs
Childrens Allergysuspension30 mg/5mLoralTopco Associates LLC2016-03-21Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralChain Drug Consortium, LLC2014-12-19Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralMeijer Distribution Inc2014-12-19Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralPreferred Plus (Kinray)2015-03-01Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralRugby Laboratories2014-12-19Not applicableUs
Childrens Allergy Fexofenadine Hydrochloridesuspension30 mg/5mLoralActavis Pharma, Inc.2014-12-22Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralHEB2015-07-01Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralCVS Pharmacy2014-12-19Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralWal Mart Stores, Inc.2015-07-01Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralKroger Company2015-07-01Not applicableUs
Childrens Allergy Reliefsuspension30 mg/5mLoralRite Aid2014-12-19Not applicableUs
Childrens Wal-fexsuspension30 mg/5mLoralWalgreen Company2014-12-19Not applicableUs
Dg Health Aller Easetablet, film coated180 mg/1oralDolgencorp, LLC2011-06-06Not applicableUs
Equaline Aller Easetablet, film coated180 mg/1oralSupervalu Inc2011-04-14Not applicableUs
Equate Allergy Relieftablet, film coated180 mg/1oralWal Mart Stores Inc2011-04-14Not applicableUs
Exchange Select Aller Easetablet, film coated180 mg/1oralArmy & Air Force Exchange Service2015-12-23Not applicableUs
Exchange Select Allergy Relieftablet, film coated180 mg/1oralArmy & Air Force Exchange Service2011-09-26Not applicableUs
Fexo Fenadinetablet, film coated180 mg/1oralHy Vee Inc2011-04-17Not applicableUs
Fexo Fenadinetablet, film coated180 mg/1oralKroger Company2011-04-16Not applicableUs
Fexo Fenadinetablet, film coated60 mg/1oralKroger Company2011-08-16Not applicableUs
Fexofenadinetablet, film coated180 mg/1oralWockhardt Limited2012-02-08Not applicableUs
Fexofenadinetablet, film coated60 mg/1oralWockhardt Limited2012-02-08Not applicableUs
Fexofenadinetablet, film coated60 mg/1oralHy Vee Inc2011-10-24Not applicableUs
Fexofenadinetablet, film coated30 mg/1oralWockhardt Limited2012-02-08Not applicableUs
Fexofenadinetablet, film coated180 mg/1oralAmerican Health Packaging2016-02-01Not applicableUs
Fexofenadine HCltablet, film coated60 mg/1oralScie Gen Pharmaceuticals, Inc.2014-12-26Not applicableUs
Fexofenadine HCltablet, film coated180 mg/1oralScie Gen Pharmaceuticals, Inc.2014-12-26Not applicableUs
Fexofenadine HCltablet180 mg/1oralValu Merchandisers Company (Best Choice)2012-06-04Not applicableUs
Fexofenadine HCltablet, film coated180 mg/1oralCVS Pharmacy2015-09-16Not applicableUs
Fexofenadine HCltablet180 mg/1oralChain Drug Consortium, LLC2012-06-18Not applicableUs
Fexofenadine HCltablet180 mg/1oralChain Drug Marketing Association2012-08-27Not applicableUs
Fexofenadine HCltablet, film coated180 mg/1oralCamber Consumer Care2015-09-16Not applicableUs
Fexofenadine HCltablet180 mg/1oralShopko Stores Operating Co., LLC.2012-06-11Not applicableUs
Fexofenadine HCltablet180 mg/1oralPreferred Plus (Kinray)2013-03-31Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAidarex Pharmaceuticals LLC2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralSafeway2011-04-15Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralCarilion Materials Management2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralAvera Mc Kennan Hospital2015-06-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-04-14Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralWal Mart Stores, Inc2015-09-30Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralGolden State Medical Supply, Inc.2014-03-20Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralMajor Pharmaceuticals2012-09-04Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralChain Drug Consortium, LLC2014-04-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMylan Pharmaceuticals Inc.2011-08-25Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralMeijer Distribution, Inc2014-12-29Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMajor Pharmaceuticals2011-04-14Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralChain Drug Marketing Associate2014-04-01Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAurolife Pharma, LLC2014-11-19Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralDr. Reddy's Laboratories Limited2011-01-03Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralAurolife Pharma, LLC2015-08-26Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAv Kare, Inc.2015-05-01Not applicableUs
Fexofenadine Hydrochloridetablet180 mg/1oralPhysicians Total Care, Inc.2011-07-27Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralDiscount Drug Mart2015-05-06Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralProficient Rx LP2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAvera Mc Kennan Hospital2015-03-13Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralAv Kare, Inc.2015-10-16Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralAurohealth LLC2015-01-15Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralDispensing Solutions, Inc.2011-04-14Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralRebel Distributors Corp2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralREMEDYREPACK INC.2013-05-20Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralFred's2015-01-15Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralSt Marys Medical Park Pharmacy2013-01-10Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralClinical Solutions Wholesale2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralDispensing Solutions, Inc.2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralRebel Distributors Corp2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralPerrigo New York Inc2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMylan Institutional Inc.2011-09-27Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralGolden State Medical Supply, Inc.2014-03-20Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMylan Pharmaceuticals Inc.2011-08-25Not applicableUs
Fexofenadine Hydrochloridetablet, film coated30 mg/1oralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralProficient Rx LP2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralCarilion Materials Management2011-04-22Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralBlenheim Pharmacal, Inc.2013-11-13Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralPerrigo New York Inc2011-08-08Not applicableUs
Fexofenadine Hydrochloridetablet, film coated180 mg/1oralWestern Family Foods Inc2011-04-14Not applicableUs
Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMylan Institutional Inc.2012-02-13Not applicableUs
Fexofenadine Hydrochloride 180tablet180 mg/1oralKaiser Permanente2012-07-05Not applicableUs
Fexofenodine Hydrochloridetablet, film coated60 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-08-08Not applicableUs
Good Neighbor Pharmacy Allergy Relieftablet, film coated180 mg/1oralAmerisource Bergen2014-08-15Not applicableUs
Good Neighbor Pharmacy Allergy Relieftablet, film coated180 mg/1oralAmerisource Bergen2011-06-22Not applicableUs
Good Sense Aller Easetablet, film coated60 mg/1oralL Perrigo Company2011-09-14Not applicableUs
Good Sense Aller Easetablet, film coated180 mg/1oralL Perrigo Company2011-04-14Not applicableUs
Harris Teeter Allergy Relieftablet, film coated180 mg/1oralHarris Teeter, LLC2015-06-24Not applicableUs
Health Mart Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMc Kesson2014-04-01Not applicableUs
Health Mart Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMc Kesson2012-01-26Not applicableUs
Health Mart Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMc Kesson2012-01-18Not applicableUs
Healthy Accents Aller Ease 24 Hourtablet, film coated180 mg/1oralDZA Brands LLC2011-06-15Not applicableUs
Healthy Accents Allergy Relieftablet, film coated180 mg/1oralDZA Brands LLC2011-06-15Not applicableUs
Kirkland Signature Aller Fextablet, film coated180 mg/1oralCostco Wholesale Company2011-04-23Not applicableUs
Leader Aller Easetablet, film coated180 mg/1oralCardinal Health2014-02-05Not applicableUs
Leader Aller Easetablet, film coated180 mg/1oralCardinal Health2011-05-16Not applicableUs
Members Mark Fexofenadinetablet, film coated180 mg/1oralSam's West Inc2011-04-14Not applicableUs
Mucinex Allergytablet180 mg/1oralReckitt Benckiser LLC2014-01-02Not applicableUs
Preferred Plus Aller Easetablet, film coated180 mg/1oralKinray2014-06-17Not applicableUs
Preferred Plus Allergy Relieftablet, film coated180 mg/1oralKinray2014-09-22Not applicableUs
Rugby Fexofenadine Hydrochloridetablet, film coated180 mg/1oralRugby Laboratories2015-01-28Not applicableUs
Shoprite Aller Easetablet, film coated180 mg/1oralWakefern Food Corporation2013-07-09Not applicableUs
Shoprite Aller Easetablet, film coated60 mg/1oralWakefern Food Corporation2013-07-09Not applicableUs
Signature Care Allergy Relieftablet, film coated180 mg/1oralSafeway2015-08-11Not applicableUs
Smart Sense Allergy Relieftablet, film coated180 mg/1oralKmart Corporation2014-08-21Not applicableUs
Smart Sense Allergy Relieftablet, film coated180 mg/1oralKmart Corporation2011-06-23Not applicableUs
Smart Sense Allergy Relieftablet, film coated60 mg/1oralKmart Corporation2011-09-01Not applicableUs
Sunmark Fexofenadine Hydrochloridetablet, film coated60 mg/1oralMc Kesson2011-09-06Not applicableUs
Sunmark Fexofenadine Hydrochloridetablet, film coated180 mg/1oralMc Kesson2011-04-14Not applicableUs
Topcare Allergy Relieftablet, film coated180 mg/1oralTopco Associates LLC2015-01-07Not applicableUs
Topcare Fexofenadine Hydrochloridetablet, film coated180 mg/1oralTopco Associates LLC2011-04-14Not applicableUs
Topcare Fexofenadine Hydrochloridetablet, film coated60 mg/1oralTopco Associates LLC2011-09-02Not applicableUs
Up and Up Allergy Relieftablet, film coated180 mg/1oralTarget Corporation2015-03-25Not applicableUs
Up and Up Allergy Relieftablet, film coated180 mg/1oralTarget Corporation2011-04-13Not applicableUs
Wal Fextablet, film coated60 mg/1oralWalgreen Company2011-08-22Not applicableUs
Wal Fex 24 Hour Allergytablet, film coated180 mg/1oralWalgreen Company2014-03-06Not applicableUs
Wal Fex Allergytablet, film coated180 mg/1oralWalgreen Company2011-04-14Not applicableUs
Wal Fex Allergytablet, film coated60 mg/1oralWalgreen Company2011-08-22Not applicableUs
Wal-fextablet180 mg/1oralWalgreens Company2011-04-13Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
FastofenNot Available
FexidineNot Available
TelfastNot Available
VifasNot Available
Brand mixtures
NameLabellerIngredients
Allegra D 12 Hour Allergy and CongestionRebel Distributors Corp
Allegra D-12 HourSanofi Aventis U.S. Llc
Allegra--d 24 HourSanofi Aventis U.S. Llc
Allegra-Dbryant ranch prepack
Allegra-D 24 HourSTAT Rx USA LLC
Allegra-D Allergy and CongestionChattem, Inc.
Fexofenadine HCl and Pseudoephedrine HciWalgreens Company
Fexofenadine HCl and Pseudoephedrine HClDr.Reddy's Laboratories Limited
Fexofenadine Hydrochloride and Pseudoephedrine HydrochlorideRebel Distributors Corp
Salts
Name/CASStructureProperties
Fexofenadine hydrochloride
ThumbNot applicableDBSALT001227
Categories
UNIIE6582LOH6V
CAS number83799-24-0
WeightAverage: 501.6564
Monoisotopic: 501.287908741
Chemical FormulaC32H39NO4
InChI KeyInChIKey=RWTNPBWLLIMQHL-UHFFFAOYSA-N
InChI
InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)
IUPAC Name
2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid
SMILES
CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • 2-phenylpropanoic-acid
  • Phenylbutylamine
  • Phenylacetate
  • Phenylpropane
  • Aralkylamine
  • Piperidine
  • Tertiary alcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • Azacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor management of Seasonal allergic rhinitis
PharmacodynamicsFexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential of terfenadine, since it does not block the potassium channel involved in repolarization of cardiac cells.
Mechanism of actionLike other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Fexofenadine exhibits no anticholinergic, antidopaminergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.
Related Articles
Absorption33%
Volume of distributionNot Available
Protein binding60%-70%
Metabolism

Approximately 5% of the total dose is metabolized, by cytochrome P450 3A4 and by intestinal microflora.

Route of eliminationNot Available
Half life14.4 hours
ClearanceNot Available
ToxicitySide effects include dizziness, drowsiness, and dry mouth.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7881
Blood Brain Barrier-0.8574
Caco-2 permeable+0.5
P-glycoprotein substrateSubstrate0.8641
P-glycoprotein inhibitor INon-inhibitor0.6791
P-glycoprotein inhibitor IINon-inhibitor0.8779
Renal organic cation transporterNon-inhibitor0.5166
CYP450 2C9 substrateNon-substrate0.836
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6458
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9162
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8421
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9756
Ames testNon AMES toxic0.9122
CarcinogenicityNon-carcinogens0.9163
BiodegradationNot ready biodegradable0.8428
Rat acute toxicity2.3481 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8469
hERG inhibition (predictor II)Inhibitor0.6258
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Sanofi aventis us llc
  • Barr laboratories inc
  • Dr reddys laboratories ltd
  • Mylan pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Sanofi-Aventis
Packagers
Dosage forms
FormRouteStrength
Suspensionoral6 mg/mL
Tabletoral60 mg
Tabletoral120 mg
Tablet, coatedoral180 mg/1
Tablet, extended releaseoral
Tablet, film coatedoral
Tablet (extended-release)oral
Tablet, orally disintegratingoral30 mg/1
Suspensionoral30 mg/5mL
Tabletoral60 mg/1
Tablet, film coatedoral30 mg/1
Tabletoral180 mg/1
Tablet, film coated, extended releaseoral
Tablet, film coatedoral180 mg/1
Tablet, film coatedoral60 mg/1
Prices
Unit descriptionCostUnit
Allegra ODT 60 30 mg Dispersible Tablet Box126.0USD box
Allegra-D 24 Hour 180-240 mg 24 Hour tablet5.01USD tablet
Allegra-d 24 hour tablet4.98USD tablet
Allegra 180 mg tablet2.89USD tablet
Allegra-D 12 Hour 60-120 mg 12 Hour tablet2.72USD tablet
Allegra-d 12 hour tablet2.49USD tablet
Fexofenadine hcl 180 mg tablet2.47USD tablet
Allegra odt 30 mg tablet1.98USD tablet
Allegra 60 mg tablet1.64USD tablet
Fexofenadine hcl 60 mg tablet1.43USD tablet
Allegra 30 mg tablet0.81USD tablet
Fexofenadine hcl 30 mg tablet0.71USD tablet
Allegra 30 mg/5ml Suspension0.25USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2134211 No1999-06-292013-04-06Canada
CA2301267 No2004-07-132018-07-21Canada
US5178878 No1993-01-122010-01-12Us
US5738872 Yes1995-08-282015-08-28Us
US5855912 Yes1995-08-282015-08-28Us
US5932247 Yes1995-08-282015-08-28Us
US6037353 Yes1997-09-142017-09-14Us
US6039974 No1998-07-312018-07-31Us
US6113942 Yes1995-08-282015-08-28Us
US6613357 No2000-12-252020-12-25Us
US6723348 No2001-11-262021-11-26Us
US8933097 No2012-08-162032-08-16Us
USRE39069 No1998-05-292018-05-29Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point142.5 °CPhysProp
water solubilitySlightly solubleNot Available
logP5.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00266 mg/mLALOGPS
logP5.02ALOGPS
logP2.94ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)4.04ChemAxon
pKa (Strongest Basic)9.01ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area81 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity147.98 m3·mol-1ChemAxon
Polarizability57.42 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Federico Milla, “Processes for the production of fexofenadine.” U.S. Patent US20030166682, issued September 04, 2003.

US20030166682
General References
  1. Smith SM, Gums JG: Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):813-22. doi: 10.1517/17425250903044967. [PubMed:19545214 ]
  2. Bachert C: A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther. 2009 May;31(5):921-44. doi: 10.1016/j.clinthera.2009.05.017. [PubMed:19539095 ]
  3. Markham A, Wagstaff AJ: Fexofenadine. Drugs. 1998 Feb;55(2):269-74; discussion 275-6. [PubMed:9506246 ]
  4. Golightly LK, Greos LS: Second-generation antihistamines: actions and efficacy in the management of allergic disorders. Drugs. 2005;65(3):341-84. [PubMed:15669879 ]
  5. Molimard M, Diquet B, Benedetti MS: Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. Fundam Clin Pharmacol. 2004 Aug;18(4):399-411. [PubMed:15312146 ]
External Links
ATC CodesR06AX26
AHFS Codes
  • 04:08.00
PDB EntriesNot Available
FDA labelDownload (43.7 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AclidiniumAclidinium may increase the anticholinergic activities of Fexofenadine.
Aluminum hydroxideThe serum concentration of Fexofenadine can be decreased when it is combined with Aluminum hydroxide.
AmphetamineAmphetamine may decrease the sedative activities of Fexofenadine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fexofenadine.
AzelastineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Fexofenadine.
Benzylpenicilloyl PolylysineFexofenadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Fexofenadine.
Botulinum Toxin Type AFexofenadine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BFexofenadine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
BuprenorphineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Calcium carbonateThe serum concentration of Fexofenadine can be decreased when it is combined with Calcium carbonate.
CathinoneCathinone may decrease the sedative activities of Fexofenadine.
Cimetropium BromideFexofenadine may increase the anticholinergic activities of Cimetropium Bromide.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
EltrombopagThe serum concentration of Fexofenadine can be increased when it is combined with Eltrombopag.
EluxadolineFexofenadine may increase the activities of Eluxadoline.
ErythromycinThe serum concentration of Fexofenadine can be increased when it is combined with Erythromycin.
EthanolFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Glucagon recombinant.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Fexofenadine.
HydrocodoneFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Fexofenadine.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Fexofenadine.
ItraconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Itraconazole.
KetoconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Ketoconazole.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fexofenadine.
LumacaftorThe serum concentration of Fexofenadine can be decreased when it is combined with Lumacaftor.
Magnesium hydroxideThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium hydroxide.
Magnesium oxideThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium oxide.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
MethotrimeprazineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetyrosineFexofenadine may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Fexofenadine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
MirabegronThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Mirabegron.
MirtazapineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MorphineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
OrphenadrineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
ParaldehydeFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Paroxetine.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
Potassium ChlorideFexofenadine may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleFexofenadine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Fexofenadine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Fexofenadine.
RamosetronFexofenadine may increase the activities of Ramosetron.
RanolazineThe serum concentration of Fexofenadine can be increased when it is combined with Ranolazine.
RifampicinThe serum concentration of Fexofenadine can be decreased when it is combined with Rifampicin.
RopiniroleFexofenadine may increase the sedative activities of Ropinirole.
RotigotineFexofenadine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Fexofenadine.
SaquinavirThe serum concentration of Fexofenadine can be increased when it is combined with Saquinavir.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Fexofenadine.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Fexofenadine.
SuvorexantFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Fexofenadine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
TeriflunomideThe serum concentration of Fexofenadine can be increased when it is combined with Teriflunomide.
TesmilifeneThe serum concentration of Fexofenadine can be decreased when it is combined with Tesmilifene.
ThalidomideFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
TiotropiumFexofenadine may increase the anticholinergic activities of Tiotropium.
TopiramateThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Topiramate.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Fexofenadine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Fexofenadine.
VerapamilThe bioavailability of Fexofenadine can be increased when combined with Verapamil.
ZolpidemFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Grapefruit and grapefruit juice should be avoided throughout treatment as grapefruit can significantly decrease serum levels of this product.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Amon U, Amon S, Gibbs BF: In vitro studies with fexofenadine, a new nonsedating histamine H1 receptor antagonist, on isolated human basophils. Inflamm Res. 2000 Apr;49 Suppl 1:S13-4. [PubMed:10864400 ]
  3. Abbas MN, Abdel Fattah AA, Zahran E: A novel membrane sensor for histamine H1-receptor antagonist "fexofenadine". Anal Sci. 2004 Aug;20(8):1137-42. [PubMed:15352500 ]
  4. Grzelewska-Rzymowska I, Kroczynska-Bednarek J, Pietrzkowicz M: [Effect of fexofenadine--selective antagonist of histamine receptor (H1) on histamine-induced bronchoconstriction]. Pol Merkur Lekarski. 2003 Jan;14(79):43-6. [PubMed:12712828 ]
  5. Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, Aoki M, Funaki Y, Itoh M, Iwata R, Wong DF, Yanai K: Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol. 2004 Aug;44(8):890-900. [PubMed:15286093 ]
  6. Cavero I, Mestre M, Guillon JM, Heuillet E, Roach AG: Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans? Drug Saf. 1999;21 Suppl 1:19-31; discussion 81-7. [PubMed:10597865 ]
  7. Devillier P, Roche N, Faisy C: Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. Clin Pharmacokinet. 2008;47(4):217-30. [PubMed:18336052 ]
  8. Dhanya NB, Thasleem Z, Rai R, Srinivas CR: Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test. Indian J Dermatol Venereol Leprol. 2008 Jul-Aug;74(4):361-3. [PubMed:18797058 ]
  9. Smith SM, Gums JG: Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):813-22. doi: 10.1517/17425250903044967. [PubMed:19545214 ]
  10. Markham A, Wagstaff AJ: Fexofenadine. Drugs. 1998 Feb;55(2):269-74; discussion 275-6. [PubMed:9506246 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
  2. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ: Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr;16(4):478-85. [PubMed:10227700 ]
  3. Petri N, Tannergren C, Rungstad D, Lennernas H: Transport characteristics of fexofenadine in the Caco-2 cell model. Pharm Res. 2004 Aug;21(8):1398-404. [PubMed:15359574 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. [PubMed:14610227 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y: Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos. 2005 Oct;33(10):1477-81. Epub 2005 Jul 13. [PubMed:16014768 ]
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Drug created on June 13, 2005 07:24 / Updated on May 26, 2016 03:15