| Version |
2.5 |
| Creation Date |
2005-06-13 13:24:05 |
| Update Date |
2009-06-23 18:07:29 |
| Primary Accession Number |
DB00971 |
| Secondary Accession Number |
|
| Name |
Selenium Sulfide |
| Drug Type |
|
| Description |
Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children. |
| Synonyms |
- SeS
- Selenium Disulfide
- Selenium sulfide red powder
- Selenium sulphide
- Sulfur selenide
|
| Brand Names |
- Exsel
- Exsel Lotion Shampoo
- Glo-Sel
- Head & Shoulders Intensive Treatment 2 in 1 (Persistent Dandruff Shampoo plus Conditioner in One) Formula Dandruff Lotion Shampoo
- Head & Shoulders Intensive Treatment Conditioning Formula Dandruff Lotion Shampoo
- Head & Shoulders Intensive Treatment Regular Formula Dandruff Lotion Shampoo
- Sebusan
- Selenium(IV) sulfide
- Selensulfid
- Selsun
- Selsun Blue
- Selsun Blue Dry Formula
- Selsun Blue Extra Conditioning Formula
- Selsun Blue Extra Medicated Formula
- Selsun Blue Oily Formula
- Selsun Blue Regular Formula
- Versel Lotion
|
| Brand Mixtures |
- Alphasel tablets (calcium phosphate [dibasic] + cobalt sulfate + D-alpha tocopheryl acetate + selenium sulfide)
- Previte (neomycin sulfate + selenium sulfide + streptomycin sulfate + vitamin A + vitamin D + vitamin E + vitamin K1)
|
| Chemical IUPAC Name |
Not Available |
| Chemical Formula |
SSe |
| Chemical Structure |
 |
| CAS Registry Number |
7446-34-6 |
| InChI Identifier |
InChI=1/SSe/c1-2 |
| InChI Key |
VIDTVPHHDGRGAF-UHFFFAOYAR |
| KEGG Drug |
Not Available |
| KEGG Compound |
Not Available |
| PubChem Compound |
24011  |
| PubChem Substance |
7852757 |
| ChEBI ID |
Not Available |
| PharmGKB ID |
PA451322 |
| HET ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
00418293 |
| RxList Link |
http://www.rxlist.com/cgi/generic/selsun.htm |
| PDRhealth Link |
Not Available |
| Wikipedia Link |
http://en.wikipedia.org/wiki/Selenium_sulfide |
| FDA Label |
Not Available |
| Material Safety Data Sheet (MSDS) |
|
| Synthesis Reference |
Not Available |
| Average Molecular Weight |
111.0300 |
| Monoisotopic Molecular Weight |
111.8886 |
| State |
Solid |
| Melting Point |
100 oC |
| Experimental Water Solubility |
Practically insoluble
Source: PhysProp
|
| Predicted Water Solubility |
Not Available
Calculated using ALOGPS
|
| Experimental LogP/Hydrophobicity |
Not Available
Source: PhysProp
|
| Predicted LogP |
Not Available
Calculated using ALOGPS
|
| Experimental LogS |
Not Available |
| Predicted LogS |
Not Available
Calculated using ALOGPS
|
| Experimental Caco2 Permeability |
Not Available |
| pKa/Isoelectric Point |
Not Available |
| Mass Spectrum |
Not Available
|
| MOL File |
Show | Download |
| SDF File |
Show | Download |
| PDB File |
Show | Download |
| 2D Structure |
|
| 3D Structure |
|
| Experimental PDB ID |
Not Available |
| Isomeric SMILES |
S=[Se] |
| Canonical SMILES |
S=[Se] |
| Drug Category |
- Antifungals for Topical Use
|
| ATC Codes |
|
| AHFS Codes |
|
| Indication |
For treatment of tinea versicolor, dandruff and seborrheic dermatitis of the scalp. |
| Pharmacology |
Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff. |
| Mechanism of Action |
Topical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione. |
| Absorption |
There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine. |
| Toxicity |
No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity. |
| Protein Binding |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Dosage Forms |
| Form |
Route |
| Liquid |
Topical |
| Lotion |
Topical |
| Shampoo |
Topical |
|
| Patient Information |
Not Available |
| Contraindications |
Show |
| Interactions |
Not Available |
| Drug Interactions |
Not Available
|
| Food Interactions |
Not Available
|
| Pathways |
Not Available
|
| General References |
- Drugs.com
- Wikipedia
- RxList
|
| Organisms Affected |
- Bacteria
- Fungi
- Humans and other mammals
|
