| Identification |
|---|
| Name |
Selenium Sulfide |
| Accession Number |
DB00971
(APRD01323)
|
| Type |
small molecule |
| Groups |
approved |
| Description |
Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children. |
| Structure |
Download:
MOL |
SDF |
SMILES |
InChI
Display:
2D Structure |
3D Structure
|
| Synonyms |
| Selenium Disulfide |
| Selenium sulfide red powder |
| Selenium sulphide |
|
| Salts |
Not Available |
| Brand names |
| Name |
Company |
| Exsel |
|
| Exsel Lotion Shampoo |
|
| Glo-Sel |
|
| Head & Shoulders Intensive Treatment 2 in 1 (Persistent Dandruff Shampoo plus Conditioner in One) Formula Dandruff Lotion Shampoo |
|
| Head & Shoulders Intensive Treatment Conditioning Formula Dandruff Lotion Shampoo |
|
| Head & Shoulders Intensive Treatment Regular Formula Dandruff Lotion Shampoo |
|
| Sebusan |
|
| Selenium(IV) sulfide |
|
| Selensulfid |
|
| Selsun |
|
| Selsun Blue |
|
| Selsun Blue Dry Formula |
|
| Selsun Blue Extra Conditioning Formula |
|
| Selsun Blue Extra Medicated Formula |
|
| Selsun Blue Oily Formula |
|
| Selsun Blue Regular Formula |
|
| Versel Lotion |
|
|
| Brand mixtures |
| Brand Name |
Ingredients |
| Alphasel tablets |
calcium phosphate [dibasic] + cobalt sulfate + D-alpha tocopheryl acetate + selenium sulfide |
| Previte |
neomycin sulfate + selenium sulfide + streptomycin sulfate + vitamin A + vitamin D + vitamin E + vitamin K1 |
|
| Categories |
- Antifungals for Topical Use
|
| CAS number |
7446-34-6 |
| Weight |
Average: 111.03
Monoisotopic: 111.888592518
|
| Chemical Formula |
SSe |
| InChI Key |
InChIKey=VIDTVPHHDGRGAF-UHFFFAOYSA-N |
| InChI |
InChI=1S/SSe/c1-2
Plain Text
|
| IUPAC Name |
sulfaneselone
|
| SMILES |
S=[Se]
Plain Text
|
| Mass Spec |
Not Available
|
| Taxonomy |
|---|
| Kingdom |
Inorganic |
| Classes |
|
| Substructures |
|
| Pharmacology |
|---|
| Indication |
For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp. |
| Pharmacodynamics |
Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff. |
| Mechanism of action |
Topical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione. |
| Absorption |
There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine. |
| Volume of distribution |
Not Available |
| Protein binding |
Not Available |
| Metabolism |
Not Available |
| Route of elimination |
Not Available |
| Half life |
Not Available |
| Clearance |
Not Available |
| Toxicity |
No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity. |
| Affected organisms |
- Humans and other mammals
- Fungi
- Bacteria
|
| Pathways |
Not Available |
| Pharmacoeconomics |
|---|
| Manufacturers |
- Allergan herbert div allergan inc
- Actavis mid atlantic llc
- Ivax pharmaceuticals inc
- Perrigo new york inc
- Taro pharmaceuticals usa inc
- Wockhardt eu operations (swiss) ag
- Chattem inc
|
| Packagers |
|
| Dosage forms |
| Form |
Route |
Strength |
| Liquid |
Topical |
|
| Lotion |
Topical |
|
| Shampoo |
Topical |
|
|
| Prices |
| Unit description |
Cost |
Unit |
| Selenium Sulfide 2.5% Lotion 118ml Bottle |
19.99 USD |
bottle |
| Selenium Sulfide 2.5% Lotion 120ml Bottle |
19.99 USD |
bottle |
| Selenium sulfide 99% powder |
5.64 USD |
g |
| Tersi 2.25% foam |
2.05 USD |
g |
| Selenium sulfide 2.25% shampoo |
0.33 USD |
ml |
| Selenium sulf 2.5% shampoo |
0.17 USD |
ml |
| Selenium 2.5% lotion-shampoo |
0.1 USD |
ml |
| Selenium sulfide 2.5% lotion |
0.1 USD |
ml |
| Selsun blue shampoo x-medic |
0.04 USD |
ml |
| Selsun blue 1% shampoo |
0.03 USD |
ml |
| Selsun blue daily shampoo |
0.03 USD |
ml |
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational
purposes only.
|
| Patents |
Not Available |
| Properties |
|---|
| State |
solid |
| Experimental Properties |
| Property |
Value |
Source |
| melting point |
100 °C |
Not Available |
| water solubility |
Practically insoluble |
Not Available |
|
| Predicted Properties |
|
| References |
|---|
| Synthesis Reference |
Not Available
|
| General Reference |
- Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4. Pubmed
- Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.×. Epub 2010 Aug 24. Pubmed
|
| External Links |
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| ATC Codes |
|
| AHFS Codes |
|
| PDB Entries |
Not Available |
| FDA label |
Not Available
|
| MSDS |
show (73.8 KB)
|
| Interactions |
|---|
| Drug Interactions |
| Drug |
Interaction |
| Eltrombopag |
Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours. |
|
| Food Interactions |
Not Available |
