You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameSelenium Sulfide
Accession NumberDB00971  (APRD01323)
TypeSmall Molecule
GroupsApproved
Description

Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children.

Structure
Thumb
Synonyms
Selenii disulfidum
Selenium disulfide
Selenium disulphide
Selenium sulfide, micronized
Selenium sulphide
Selenium sulphide, micronized
Selenium(IV) disulfide
Selenium(IV) disulphide
Selenium(IV) sulfide
Selenium(IV) sulphide
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Selenium Sulfidelotion2.5 mg/100mLtopicalPerrigo New York Inc2006-09-25Not applicableUs
Selenium Sulfidelotion25 mg/mLtopicalCentral Texas Community Health Centers1983-09-01Not applicableUs
Selenium Sulfidelotion25 mg/mLtopicalMorton Grove Pharmaceuticals, Inc.1983-09-01Not applicableUs
Selenium Sulfidelotion2.5 g/100mLtopicalPhysicians Total Care, Inc.2006-09-25Not applicableUs
Selenium Sulfidelotion2.5 mg/100mLtopicalA S Medication Solutions Llc2006-09-25Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Antidandruff Medicatedshampoo1 mL/100mLtopicalSAFEWAY INC2010-08-05Not applicableUs
Antidandruff Medicatedshampoo1 mL/100mLtopicalCVS Pharmacy Inc2010-07-06Not applicableUs
Care One Medicatedliquid10 mg/mLtopicalAmerican Sales Company2013-08-15Not applicableUs
Care One Moisturizingliquid10 mg/mLtopicalAmerican Sales Company2013-07-15Not applicableUs
Careone Medicated Dandruffliquid10 mg/mLtopicalAmerican Sales Company2014-11-17Not applicableUs
Careone Moisturizing Dandruffliquid10 mg/mLtopicalAmerican Sales Company2015-01-13Not applicableUs
Careone Moisturizing Dandruffshampoo1 mL/100mLtopicalAmerican Sales Company2011-08-19Not applicableUs
Cvs Pharmacy Dandruff Moisturizing With Aloeshampoo1 mL/100mLtopicalCVS Pharmacy Inc2010-10-15Not applicableUs
Cvs Pharmacy Maximum Strength Dandruffliquid10 mg/mLtopicalCVS Pharmacy2014-11-17Not applicableUs
Cvs Pharmacy Medicatedliquid10 mg/mLtopicalCVS Pharmacy2013-07-08Not applicableUs
Dandruffshampoo10 mg/mLtopicalCVS2012-12-09Not applicableUs
Dandruffshampoo10 mg/mLtopicalMeijer Distribution2013-06-01Not applicableUs
Dandruffshampoo10 mg/mLtopicalKroger2013-06-01Not applicableUs
Daylogic Maximum Strength Dandruffliquid10 mg/mLtopicalRite Aid Corporation2013-03-26Not applicableUs
Dg Body Medicated Dandruffshampoo1 mL/100mLtopicalDolgencorp Inc2010-09-29Not applicableUs
Equaline Aloeliquid10 mg/mLtopicalSUPERVALU INC.2013-06-10Not applicableUs
Equaline Clinical Strengthliquid10 mg/mLtopicalSUPERVALU INC.2013-02-14Not applicableUs
Equaline Medicated Dandruffshampoo1 mL/100mLtopicalSupervalu Inc2010-09-29Not applicableUs
Equaline Medicated Dandruffshampoo1 mL/100mLtopicalSUPERVALU INC.2012-04-30Not applicableUs
Equaline Mentholliquid10 mg/mLtopicalSUPERVALU INC.2013-06-10Not applicableUs
Equaline Moisturizing Dandruffshampoo1 mL/100mLtopicalSUPERVALU INC.2012-03-23Not applicableUs
Equaline Moisturizing Dandruff Medicated Formulashampoo1 mL/100mLtopicalSupervalu Inc2010-10-15Not applicableUs
Equateliquid10 mg/mLtopicalWal Mart Stores Inc.2013-06-21Not applicableUs
Equate Aloeliquid10 mg/mLtopicalWal Mart Stores Inc2013-11-25Not applicableUs
Equate Clinical Strength Dandruffliquid10 mg/mLtopicalWal Mart Stores Inc2014-08-17Not applicableUs
Equate Critical Strengthliquid10 mg/mLtopicalWal Mart Stores Inc.2012-09-19Not applicableUs
Equate Medicated Dandruffliquid10 mg/mLtopicalWal Mart Stores Inc2014-08-17Not applicableUs
Equate Moisturizing Dandruffliquid10 mg/mLtopicalWal Mart Stores Inc2014-08-17Not applicableUs
Head and Shoulders Clinical Strengthlotion/shampoo1 g/100mLtopicalProcter & Gamble Manufacturing Co.2010-07-01Not applicableUs
Healthy Accentsliquid10 mg/mLtopicalDZA Brands LLC2013-07-02Not applicableUs
Healthy Accents Medicated Dandruffshampoo1 mL/100mLtopicalDZA Brands LLC2010-09-29Not applicableUs
Healthy Accents Medicated Dandruffliquid10 mg/mLtopicalDZA Brands LLC2014-08-17Not applicableUs
Heb Dandruffshampoo1 mL/100mLtopicalH E B2011-08-08Not applicableUs
Kroger Medicated Dandruffliquid10 mg/mLtopicalTHE KROGER COMPANY2014-06-24Not applicableUs
Lethechniq Dandruff Moisturizingshampoo1 mL/100mLtopicalHy Vee, Inc2010-10-15Not applicableUs
Medicated Dandruffshampoo10 mg/mLtopicalSUPERVALU INC.2015-01-19Not applicableUs
Medicated Dandruffshampoo1 kg/100LtopicalKroger co1990-01-15Not applicableUs
Medicated Dandruffshampoo1 kg/100LtopicalDolgencorp.LLC2011-11-03Not applicableUs
Medicated Dandruffshampoo1 mL/100mLtopicalAmerican Sales Company2011-08-19Not applicableUs
Medicated Dandruffshampoo1 kg/100Ltopicaltarget Corp1990-02-15Not applicableUs
Medicated Dandruff Maximum Strengthshampoo1 mL/100mLtopicalWal Mart Stores Inc2011-08-19Not applicableUs
Moisturizing Selsun Blueshampoo1.0 %topicalChattem Canada1996-12-312008-07-20Canada
Naturaltech Purifying Anti-dandruffshampoo.6 mL/100mLtopicalDavines S.p.A.2012-02-29Not applicableUs
Renewal Dandruff Moisturizingliquid10 mg/mLtopicalRite Aid Corporation2015-03-03Not applicableUs
Renewal Medicatedliquid10 mg/mLtopicalRite Aid Corporation2014-01-13Not applicableUs
Rexall Aloeliquid10 mg/mLtopicalDOLGENCORP INC.2013-07-31Not applicableUs
Rexall Aloeliquid1 mL/100mLtopicalDOLGENCORP INC.2012-09-25Not applicableUs
Rite Aid Medicated Dandruffshampoo1 mL/100mLtopicalRite Aid Corporation2010-09-29Not applicableUs
Rite Aid Moisturizing Dandruff Medicated Formulashampoo1 mL/100mLtopicalRite Aid Corporation2012-03-20Not applicableUs
Rite Aid Renewalliquid10 mg/mLtopicalRite Aid Corporation2013-06-20Not applicableUs
Rite Aid Renewal Medicatedliquid10 mg/mLtopicalRite Aid Corporation2013-07-15Not applicableUs
Rugby Anti-dandruffshampoo10 mg/mLtopicalRugby Laboratories, Inc.2012-05-01Not applicableUs
Safewayliquid10 mg/mLtopicalSafeway Inc.2013-06-20Not applicableUs
Safeway Care Medicated Dandruffliquid10 mg/mLtopicalSAFEWAY INC2014-02-25Not applicableUs
Safeway Medicated Dandruffshampoo1 mL/100mLtopicalSafeway Inc.2012-06-04Not applicableUs
Selenium Sulfideshampoo10 mg/mLtopicalSonar Products, Inc2012-02-08Not applicableUs
Selsun Azul Revitalizanteshampoo1 g/100mLtopicalChattem, Inc.2012-12-01Not applicableUs
Selsun Azul Suave Y Manejable Humectanteshampoo1 g/100mLtopicalChattem, Inc.2012-12-01Not applicableUs
Selsun Blue 2-IN-1shampoo1 g/100mLtopicalChattem, Inc.2002-04-01Not applicableUs
Selsun Blue Accion Humetanteshampoo1 g/100mLtopicalChattem, Inc.2012-12-01Not applicableUs
Selsun Blue Medicatedshampoo1 g/100mLtopicalChattem, Inc.2002-04-01Not applicableUs
Selsun Blue Moisturizingshampoo1 g/100mLtopicalChattem, Inc.2002-04-01Not applicableUs
Selsun Blue Normal To Oilyshampoo1 g/100mLtopicalChattem, Inc.2002-04-01Not applicableUs
Selsun Blue, 2-IN-1shampoo1 %topicalChattem Canada1986-12-312008-07-20Canada
Selsun Blue, Normal Oily Hairshampoo1.0 %topicalChattem Canada1980-12-312008-07-20Canada
Selsun Oroshampoo.025 g/mLtopicalChattem, Inc.1952-08-01Not applicableUs
Topcare Gentle Dandruff Clinical Strengthliquid10 mg/mLtopicalTopco Associates LLC2014-07-28Not applicableUs
Topcare Medicated Dandruffshampoo1 mL/100mLtopicalTopco Associates LLC2010-09-29Not applicableUs
Topcare Medicated Dandruffliquid10 mg/mLtopicalTopco Associates LLC2014-11-17Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Selenium Sulfideshampoo22.5 mg/mLtopicalMethod Pharmaceuticals, Llc2015-06-01Not applicableUs
Selenium Sulfideshampoo22.5 mg/mLtopicalRochester Pharmaceuticals2011-03-30Not applicableUs
Selenium Sulfideshampoo22.5 mg/mLtopicalBi Coastal Pharma International Llc2011-06-01Not applicableUs
Selrxshampoo23 mg/mLtopicalArtesa Labs, Llc2011-08-31Not applicableUs
Tersiaerosol, foam1.44 g/70gtopicalQuinnova Pharmaceuticals, Inc.2009-12-01Not applicableUs
International Brands
NameCompany
Exsel Lotion ShampooNot Available
Glo-SelNot Available
Head & Shoulders Intensive TreatmentNot Available
Versel LotionNot Available
Brand mixtures
NameLabellerIngredients
Clease and TreatQuinnova Pharmaceuticals, Inc.
SaltsNot Available
Categories
UNIIZ69D9E381Q
CAS number7488-56-4
WeightAverage: 143.09
Monoisotopic: 143.860663208
Chemical FormulaS2Se
InChI KeyJNMWHTHYDQTDQZ-UHFFFAOYSA-N
InChI
InChI=1S/S2Se/c1-3-2
IUPAC Name
thione
SMILES
S=[Se]=S
Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other nonmetals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative Parents
Substituents
  • Homogeneous other non metal
  • Inorganic sulfide
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp.
PharmacodynamicsSelenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.
Mechanism of actionTopical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione.
Related Articles
AbsorptionThere is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNo documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity.
Affected organisms
  • Humans and other mammals
  • Fungi
  • Bacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9946
Blood Brain Barrier+0.9786
Caco-2 permeable+0.6224
P-glycoprotein substrateNon-substrate0.908
P-glycoprotein inhibitor INon-inhibitor0.9531
P-glycoprotein inhibitor IINon-inhibitor0.9963
Renal organic cation transporterNon-inhibitor0.9254
CYP450 2C9 substrateNon-substrate0.8623
CYP450 2D6 substrateNon-substrate0.8451
CYP450 3A4 substrateNon-substrate0.8077
CYP450 1A2 substrateNon-inhibitor0.7526
CYP450 2C9 inhibitorNon-inhibitor0.7658
CYP450 2D6 inhibitorNon-inhibitor0.9304
CYP450 2C19 inhibitorNon-inhibitor0.8352
CYP450 3A4 inhibitorNon-inhibitor0.891
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7268
Ames testNon AMES toxic0.8363
CarcinogenicityCarcinogens 0.6874
BiodegradationNot ready biodegradable0.9612
Rat acute toxicity2.2807 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.933
hERG inhibition (predictor II)Non-inhibitor0.9694
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Allergan herbert div allergan inc
  • Actavis mid atlantic llc
  • Ivax pharmaceuticals inc
  • Perrigo new york inc
  • Taro pharmaceuticals usa inc
  • Wockhardt eu operations (swiss) ag
  • Chattem inc
Packagers
Dosage forms
FormRouteStrength
Clothtopical
Lotion/shampootopical1 g/100mL
Shampootopical1 kg/100L
Shampootopical.6 mL/100mL
Liquidtopical10 mg/mL
Liquidtopical1 mL/100mL
Shampootopical1 mL/100mL
Shampootopical10 mg/mL
Lotiontopical2.5 mg/100mL
Lotiontopical2.5 g/100mL
Lotiontopical25 mg/mL
Shampootopical22.5 mg/mL
Shampootopical23 mg/mL
Shampootopical1 g/100mL
Shampootopical1 %
Shampootopical1.0 %
Shampootopical.025 g/mL
Aerosol, foamtopical1.44 g/70g
Prices
Unit descriptionCostUnit
Selenium Sulfide 2.5% Lotion 118ml Bottle19.99USD bottle
Selenium Sulfide 2.5% Lotion 120ml Bottle19.99USD bottle
Selenium sulfide 99% powder5.64USD g
Tersi 2.25% foam2.05USD g
Selenium sulfide 2.25% shampoo0.33USD ml
Selenium sulf 2.5% shampoo0.17USD ml
Selenium 2.5% lotion-shampoo0.1USD ml
Selenium sulfide 2.5% lotion0.1USD ml
Selsun blue shampoo x-medic0.04USD ml
Selsun blue 1% shampoo0.03USD ml
Selsun blue daily shampoo0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point100 °CNot Available
water solubilityPractically insolubleNot Available
Predicted Properties
PropertyValueSource
logP0.91ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity31.98 m3·mol-1ChemAxon
Polarizability9.59 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4. [PubMed:10821151 ]
  2. Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.x. Epub 2010 Aug 24. [PubMed:20735804 ]
External Links
ATC CodesD01AE13
AHFS Codes
  • 84:04.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.8 KB)
Interactions
Drug InteractionsNo interactions found.
Food InteractionsNot Available
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on May 06, 2016 10:08