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Identification
NameChlorphenamine
Accession NumberDB01114  (APRD00001, DB09440)
TypeSmall Molecule
GroupsApproved
Description

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]

Structure
Thumb
Synonyms
1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
1-(P-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine
2-[P-chloro-alpha-[2-(dimethylamino)Ethyl]benzyl]pyridine
3-(P-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
Chlorophenylpyridamine
Chlorphenamin
Chlorphenamine
Chlorphenaminum
Chlorpheniramine
Chlorpheniraminum
Clofeniramina
Clorfenamina
Clorfeniramina
gamma-(4-Chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
Haynon
γ-(4-chlorophenyl)-γ-(2-pyridyl)propyldimethylamine
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chlorpheniramine Maleate Injection USPliquid10 mgintramuscular; intravenous; subcutaneousOmega Laboratories LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chlorpheniramine Maleate Tab 4mgtablet4 mgBionatal Drug Co1979-12-311999-07-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chlorpheniramine Maleate Tab 4mgtablet4 mgEverest Pharmaceuticals Ltd.1979-12-311999-07-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chlortripolon Inj 10mg/mlliquid10 mgintramuscular; intravenous; subcutaneousSchering Plough Canada Inc1953-12-311999-08-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription ProductsNot Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
4 Hour Allergy Relieftablet4 mg/1oralBetter Living Brands, Llc1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Aller-chlortablet4 mg/1oralRugby Laboratories1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Aller-chlorsyrup2 mg/5mLoralRugby Laboratories, Inc.2003-01-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Aller-chlorsyrup2 mg/5mLoralRugby Laboratories2014-03-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralHy Vee Inc1991-07-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralA S Medication Solutions Llc1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralAidarex Pharmaceuticals LLC1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralSUPERVALU INC.1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralKroger Company1987-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralMajor Pharmaceuticals1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralH E B1994-10-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralA S Medication Solutions Llc1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralCardinal Health1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet4 mg/1oralAllegiant Health2014-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Nitetablet4 mgoralBayer Inc Consumer CareNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Allergy Relieftablet, coated4 mg/1oralChain Drug Marketing Association2014-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet4 mg/1oralKareway Product, Inc.2011-08-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet4 mg/1oralCVS Pharmacy1987-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet4 mg/1oralKroger Company1987-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet4 mg/1oralGeri Care Pharmaceutical Corp2004-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet4 mg/1oralFamily Dollar1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet4 mg/1oralChain Drug Consortium1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet4 mg/1oralRite Aid1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relief 4 Hourtablet4 mg/1oralWin Co Foods, Llc1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Timetablet4 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Timetablet4 mg/1oralTIME CAP LABS INC2011-02-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Anti Allergytablet4 mg/1oralAdvance Pharmaceutical Inc.2002-01-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Allergy Relieftablet4 mg/1oralAmerican Sales Company2004-05-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlor-allergy 4-hourtablet4 mg/1oralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlor-trimeton 12 Hourtablet, extended release12 mg/1oralSchering Plough Health Care Products2010-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlor-trimeton 4hourtablet4 mg/1oralMSD Consumer Care, Inc.1975-12-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlor-tripolontablet4 mgoralBayer Inc Consumer Care1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chlor-tripolon 12 Hourtablet (extended-release)12 mgoralBayer Inc Consumer Care1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chlor-tripolon Night Time Allergy Relieftablet12 mgoralSchering Plough Canada IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chlorphen SRtablet, film coated, extended release12 mg/1oralGm Pharmaceuticals2010-06-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniraminetablet4 mg/1oralL&R Distributors, Inc.1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralCardinal Health2011-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralContract Pharmacy Services Pa2010-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet, film coated, extended release12 mg/1oralKvk Tech, Inc.2010-06-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralContract Pharmacy Services Pa2010-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralContract Pharmacal Corp2001-01-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralClinical Solutions Wholesale2000-05-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralContract Pharmacy Services Pa2011-01-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralSDA Laboratories, Inc.2010-05-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralRugby Laboratories Inc.2000-05-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet4 mg/1oralbryant ranch prepack2000-05-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleatetablet, film coated, extended release12 mg/1oralCARDINAL HEALTH, INC.2010-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlorpheniramine Maleate 4mg Tablettablet4 mgoralJamp Pharma Corporation2005-02-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chlorpheniramine Tablets, 4 mgtablet4 mgoralLogan Pharmaceuticals Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chlortabtablet4 mg/1oralWestern Family Foods Inc2007-05-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlortabstablet4 mg/1oralWal Mart Stores Inc1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Chlortripolon Syr 2.5mg/5mlsyrup2.5 mgoralSchering Plough Canada Inc1951-12-312007-08-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Clear Choice Allergy Relieftablet4 mg/1oralAthlete's Needs Inc2012-08-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cvshealth Childrens Allergy Relief Popslozenge2 mg/1oralCVS Pharmacy, Inc.2015-10-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ed Chlorpedliquid2 mL/mLoralEDWARDS PHARMACEUTICALS, INC.2011-04-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ed Chlorped Jrliquid2 mg/5mLoralEDWARDS PHARMACEUTICALS, INC.2011-03-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ed-chlortantablet, coated4 mg/1oralEDWARDS PHARMACEUTICALS, INC.2011-06-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Allergytablet4 mg/1oralSupervalu Inc2004-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Allergytablet4 mg/1oralAmerisource Bergen1989-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Allergytablet4 mg/1oralL Perrigo Company1991-07-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Allergy Relief 4 Hourtablet4 mg/1oralL. Perrigo Company1991-07-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Haben Herbcapsule1.25 mg/1oralBeverly Hills Holdings Co,. Ltd.2014-08-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Allergy Relieftablet4 mg/1oralMc Kesson2012-01-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Histalon Tab 4mgtablet4 mgoralIcn Canada Ltd.1962-12-311998-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Medique Chlorphentablet4 mg/1oralUnifirst First Aid Corporation2011-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Novo-pheniramtablet4 mgoralTeva Canada Limited1967-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sun Mark Allergy Antihistaminetablet4 mg/1oralMc Kesson2003-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Teldrin Allergy Relieftablet4 mg/1oralGemini Pharmaceuticals, Inc.2010-07-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Allergytablet4 mg/1oralTopco Associates LLC1995-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Allergy Relief 4 Hourtablet4 mg/1oralTopco Associates LLC1995-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Wal-finatetablet4 mg/1oralWALGREEN CO.1992-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
International Brands
NameCompany
Chlo-AmineNot Available
Chlor-TrimetonSchering-Plough
HaynonNot Available
PiritonGlaxoSmithKline
Brand mixtures
NameLabellerIngredients
999 Cold RemedyChina Resources Sanjiu Medical & Pharmaceutical Co Ltd
999 Cold Remedy GranularChina Resources Sanjiu Medical & Pharmaceutical Co Ltd
999 Ganmaoling ColdKingsway
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine HydrochlorideAAA Pharmaceutical, Inc.
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine HydrochlorideAAA Pharmaceutical, Inc.
Acti PEP & L Development, LLC
Actifed PEMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Actifed PE PlusMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Adult Flu and Cough SanafluGrandall Distributing Co., Inc.
Advil Allergy and Congestion ReliefPfizer Consumer Healthcare
Advil Allergy SinusPfizer Consumer Healthcare
Advil Cold and Sinus NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold and Sinus PlusPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Alka-seltzer PlusLil' Drug Store Products, Inc
Alka-seltzer Plus Cold and CoughBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Cold and Cough FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Cold Formula (cherry Burst)Bayer Health Care Consumer Care
Alka-seltzer Plus Cold Formula (orange Zest)Bayer Health Care Consumer Care
Alka-seltzer Plus Cold Medicine Sparkling OriginalBayer Health Care Consumer Care
Alka-seltzer Plus Fast Crystals Packs Cold FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Fast Packs Cold and Flu FormulaBayer Corporation Consumer Care Division
Alka-seltzer Plus Flu FormulaBayer Corporation Consumer Care Division
Alka-seltzer Plus Severe Cold and Flu FormulaBayer Health Care Llc Consumer Care
Alka-seltzer Plus Severe Sinus and ColdBayer Health Care Consumer Care
Alka-seltzer Plus-D Multi-symptom Sinus and ColdBayer Health Care Llc, Consumer Care
Allerest PEInsight Pharmaceuticals
AllerfedL&R Distributors, Inc.
Allerfed Cold and AllergyChain Drug Marketing Association Inc
Allerfed Cold and Allergy PEWestern Family Foods, Inc.
Allergie Extra FortTherapharma Inc.
AllergyL. Perrigo Company
Allergy + Sinus Relief Extra Strength TabletsPharmetics (2011) Inc
Allergy + Sinus Relief Extra Strength Tablets PEPharmetics (2011) Inc
Allergy + Sinus Relief Regular CapletsPharmetics (2011) Inc
Allergy and Pain Relief Multi-symptomWin Co Foods, Llc
Allergy and Sinus PE Maximum StrengthMeijer
Allergy and Sinus Relief Extra StrengthJamp Pharma Corporation
Allergy and Stuffy NoseAccudial Pharmaceutical, Inc.
Allergy Multi SymptomKroger Company
Allergy Multi-symptomL&R Distributors, Inc.
Allergy Multi-symptom ReliefFRED'S, INC.
Allergy Mutli-symptomArmy and Air Force Exchange Service
Allergy Pain ReliefHy Vee Inc
Allergy ReliefKroger Company
Allergy Relief Multi-symptomDolgencorp, LLC
Allergy Relief MultisymptomSelect Corporation
Allergy Sinus MedicationLil' Drug Store Products Inc
Allergy Sinus Medication - CapletWestcan Pharmaceuticals Ltd.
Allergy Sinus PEPublix Super Markets Inc
Allergy Sinus PE Pain ReliefPublix Super Markets Inc
Allpanto SSAMSUNG PHARM IND. CO., LTD.
Altilan ClAlternative Pharmacal Corporation
Ana-kit (2mg/tab Orl, 1mg/ml Liq Sc Im)Hollister Stier Laboratories Llc
Anakit Insect Sting Treatment KitHollister Stier, Unit Pharm, Division Of Miles Canada Inc.
Aphedrid Cold and AllergyArmy and Air Force Exchange Service
Atuss DS Tannate SuspensionAtley Pharmaceuticals, Inc.
Bactimicina Childrens Cough and ColdDLC Laboratories, Inc.
Baczol Cold MedicineLex Inc
Balamine DM SyrupBallay Pharmaceuticals, Inc.
Benylin 1 Nightime With MenthactinMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin A-D-AH Extra Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin A-D-AH Regular Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Night Extra Strength SyrupMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Cold & Sinus PlusMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Cold and Sinus NightMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin D-AH for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D-AH Chewables for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D-AH for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Extra Strength All-IN-one Cold and Flu NightimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Extra Strength Mucus & Phlegm Plus Cold Relief NightMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children All-IN-one Cold & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children All-IN-one Cold and FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children Cough Stuffy and Runny NoseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Bio-B KidsAdvanced Generic Corporation
Bio-rytussAdvanced Generic Corporation
Broncochem Cold and Flu TeaLaboratorio Magnachem International Srl
BronkidsPortal Pharmaceutical
Buckley's Complete Extra Strength Cough, Cold and Flu NightThe Buckley's Company
CapcofCapital Pharmaceutical, Llc
Carbaphen ChGil Pharmaceutical Corp
Carbaphen Ped ChGil Pharmaceutical Corp
Care One Cold and AllergyAmerican Sales Company
Care One Cold Head CongestionAmerican Sales Company
Care One Cold Multi SymptomAmerican Sales Company
Care One Sinus and Allergy PEAmerican Sales Company
CarepantoSAMSUNG PHARM IND. CO., LTD.
Children's Advil Cold & Flu Multi-symptomPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Children's Coltalin Fruit Flavor Chewable Cold TabletsFortune Pharmacal Co. Ltd.
Children's Nicold MedicineTanta Pharmaceuticals Inc
Children's Nyquil LiquidProcter & Gamble Inc
Children's Tylenol ColdMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold and CoughMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold Chewable TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold LiquidMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold Liquid With DMMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold SuspensionMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Complete Cold, Cough & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cough and Runny NoseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Childrens ColtalinFortune Pharmacal Company Limited
Childrens Dimetapp Long Acting Cough Plus ColdRichmond Division of Wyeth
Childrens Dimetapp Multisymptom Cold and FluRichmond Division of Wyeth
Childrens Flu ReliefCVS Pharmacy
Childrens Multi Symptom Fever and ColdKroger Company
Childrens Multi-symptom Cold Plus Dye-freeQUALITY CHOICE (Chain Drug Marketing Association)
Childrens Plus ColdWalgreens
Childrens Plus Cold GrapeCVS
Childrens Plus Cough and Runny NoseWalgreens
Childrens Plus FluWalgreens
Childrens Plus Flu With PECVS
Childrens Plus Multi Symptom ColdWalgreens
Childrens Plus Multi Symptom Cold Dye FreeAmerisource Bergen (Good Neighbor Pharmacy) 46122
Childrens Plus Multi-symptom Cold Grape With PERite Aid
Childrens Plus Multi-symptom Grape With PEBest Choice
Childrens Plus Multi-symptom With PEKinray, Inc
Childrens Robitussin Cough and Cold Long-actingRichmond Division of Wyeth
Childrens Robitussin Nighttime Cough Long-acting DMRichmond Division of Wyeth
Chlor Tripolon Decongest SyrSchering Plough Canada Inc
Chlor-tripolon Decon Ext Str Repetabs 12Schering Plough Canada Inc
Chlorpheniramine Maleate, Phenylephrine HydrochlorideAAA Pharmaceutical, Inc.
Codar ArRespa Pharmaceuticals, Inc.
Codeine and Chlorpheniramine Maleate ERNexgen Pharma, Inc.
ColdHy Vee Inc
Cold & CoughPharma Strides Canada Corporation
Cold & Cough Extra StrengthPharma Strides Canada Corporation
Cold & Stuffy NoseAccudial Pharmaceutical Inc
Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus PlusVita Health Products Inc
Cold and AllergyMeijer Distribution Inc
Cold and Allergy Maximum StrengthAmerisource Bergen (Good Neighbor Pharmacy)
Cold and Allergy PEKroger Company
Cold and Allergy ReliefRite Aid
Cold and Cough High Blood PressureVALUE MERCHANDISERS COMPANY, INC.
Cold and FluRite Aid
Cold and Flu BPL&R Distributors, Inc.
Cold and Flu HbpWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Cold and Flu Nighttime Relief Syrup Extra StrengthPharmetics (2011) Inc
Cold and Flu Relief Hbp Maximum Strength Multi-symptomRite Aid
Cold and Nasal Congestion Relief Nighttime Extra StrengthPharmetics (2011) Inc
Cold and Sinus PlusInternational Pharmaceutical Generics Ltd
Cold Head Congestion Daytime / NighttimeAAA Pharmaceutical, Inc.
Cold Head Congestion Night TimeDolgencorp, LLC
Cold Head Congestion NighttimeAmerican Sales Company
Cold Medication Extra Strength Night TimePharmascience Inc
Cold Medication Reg Strength N TabProdemdis Enr.
Cold Medication Regular Nighttime TabletsPharmetics (2011) Inc
Cold Medication Regular Nighttime Tablets PEPharmetics (2011) Inc
Cold Medicine XL-3 for ChildrenSelder, S.A. de C.V.
Cold Medicine Xl3Selder, S.A. de C.V.
Cold Multi Symptom Daytime NighttimeChain Drug Marketing Association
Cold Multi Symptom NighttimeChain Drug Marketing Association
Cold Multi-symptom Daytime NighttimeAAA Pharmaceutical, Inc.
Cold Multi-symptom Night-timeAllegiant Health
Cold Multi-symptom NighttimeAmerican Sales Company
Cold PEHy Vee Inc
Cold ReliefMeijer Distribution Inc
Cold Relief Multi SymptomMeijer Distribution Inc
Cold Relief Multi-symptomTop Care
Cold Relief Nightime TabletJamp Pharma Corporation
Cold Remedy Gan Mao LingInternational Nature Nutraceuticals
Cold Remedy SoothingInternational Nature Nutraceuticals
Cold,sore Throat Pain & Cough Ultra StrengthThe Winning Combination Inc.
Coldaside ColdTanta Pharmaceuticals Inc
Coldaside Cold & Flu Extra StrengthTanta Pharmaceuticals Inc
Coldaside Cough & ColdTanta Pharmaceuticals Inc
ColtalinFortune Pharmacal Company Limited
Coltalin Cold & Allergy TabletsFortune Pharmacal Co. Ltd.
Coltalin-DMFortune Pharmacal Company Limited
Complete Allergy and Sinus Multi SymptomGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.
Complete One Cold and Flu Nightime Extra Strength LiquidTanta Pharmaceuticals Inc
Comtrex Cough and Cold Day/nightDucere Pharma LLC
Conrx Allergy SinusEagle Distributors,Inc
Conrx Allergy Sinus Multi-symptomsEagle Distributors,Inc.
Contac Cold and Flu Maximum StrengthMeda Consumer Healthcare Inc.
Contac Cold and Flu NightMeda Consumer Healthcare Inc.
Contac Cold CapsulesSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contac Cold Extra Strength CapsulesSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contac Cold Nasal Congestion-nighttimeGlaxosmithkline Consumer Healthcare Inc.
Contac Cough Cold and Flu CapletsSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contac Night Cough SyrupGlaxosmithkline Consumer Healthcare Inc.
Contact C SrcSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
CopantoSAMSUNG PHARM IND. CO., LTD.
Coricidin Cold & FluBayer Inc Consumer Care
Coricidin Cold & Flu Extra StrengthBayer Inc Consumer Care
Coricidin Cold & Flu Multi-symptomBayer Inc Consumer Care
Coricidin Cough & ColdBayer Inc Consumer Care
Coricidin D Flu, Nasal and SinusSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.
Coricidin D Long Acting TabSchering Plough Canada Inc
Coricidin D TabSchering Plough Canada Inc
Coricidin Hbp Cold and FluMSD Consumer Care, Inc.
Coricidin Hbp Cough and Cold Cough Suppressant, AntihistamineMSD Consumer Care, Inc.
Coricidin Hbp Day and NightMSD Consumer Care, Inc.
Coricidin Hbp Maximum Strength FluMSD Consumer Care, Inc.
Coricidin Sinus Headache TabSchering Plough Canada Inc
Coricidin TabSchering Plough Canada Inc
Corsym SuspensionCiba Self Medication
Cough & ColdAccudial Pharmaceutical Inc
Cough and ColdMajor Pharmaceuticals
Cough and Cold HbpSafeway
Cough and Cold Hbp Decongestant-freeL.N.K. International, Inc.
Cough and Cold Relief HbpSUPERVALU INC.
Cough and Cold Xl3 XtraProgela, S.A. De C.V.
Cough and Runny Nose Childrens PlusTOP CARE (Topco Associates LLC)
Cough, Cold & Flu Super StrengthThe Winning Combination Inc.
Counteract Sinus and AllergyMelaleuca Of Canada Inc.
Dallergy DropsLaser Pharmaceuticals, LLC
De-chlor DMCypress Pharmaceutical, Inc.
Defensol DMenper Distributors, Inc.
Defensol D (multi Symptom Effervescent Tablets)Menper Distributors Inc.
Dg Health Allergy Multi SymptomDolgencorp, LLC
Dg Health Cold and AllergyDolgencorp Inc
Dg Health Cold Head CongestionDolgencorp, LLC
Dg Health Cold Multi Symptom Nite TimeDolgencorp Inc
Dg Health Sinus Congestion and PainDolgencorp, LLC
Dimetapp Nighttime Cold Extra Strength CapletsPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetapp Nighttime Cold TabletsWyeth Consumer Healthcare Inc.
Dometuss-DADomel Laboratories
DonatussinLaser Pharmaceuticals, LLC
Donatussin DM Drops DMLaser Pharmaceuticals, LLC
Dristan CapsulesWhitehall Robins Inc.
Dristan Cold MultisymptomPfizer Consumer Healthcare
Dristan Extra Strength CapletsPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dristan TabletsPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
DrymaxJay Mac Pharmaceuticals Llc
Drymax AFJay Mac Pharmaceuticals
Ed A-histEDWARDS PHARMACEUTICALS, INC.
Ed A-hist DMEDWARDS PHARMACEUTICALS, INC.
Ed Chlorped DEDWARDS PHARMACEUTICALS, INC.
Ed-A-hist DMEDWARDS PHARMACEUTICALS, INC.
Effervescent Cold ReliefCardinal Health, Inc
Endacof CLarken Laboratories, Inc.
Entre-SBrookstone Pharmaceuticals, Inc.
Equaline Childrens ColdSupervalu Inc
Equaline Nighttime Cold Multi SymptomSupervalu Inc
Extra Strength Allergy and Sinus ReliefPendopharm Division Of De Pharmascience Inc
Extra Strength Allergy Plus Sinus ReliefKsl Pharmaceuticals
Extra Strength Allergy Sinus MedicationStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Extra Strength Cold Medication Night Time ReliefGenvion Corporation
Extra Strength Cold Medication Nighttime ReliefVita Health Products Inc
Extra Strength Cold Medication Nighttime RlfStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Extra Strength Contac C - SrcSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Extra Strength Neocitran Flu NightNovartis Consumer Health Canada Inc.
Extra Strength Neocitran Total NightNovartis Consumer Health Canada Inc.
Extra Strength Nighttime Cold ReliefPendopharm Division Of De Pharmascience Inc
Extra Strength Nighttime Cold Relief PEVita Health Products Inc
Extra Strength Nighttime Cold Relief-capletKsl Pharmaceuticals
Extra Strength Nighttime Flu PEVita Health Products Inc
Extra Strength Tylenol AllergyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Allergy Sinus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold & Sinus NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold and Flu PowderMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold Nighttime CapletMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Sinus NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Sinus Pain and Congestion NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Flu Bp Maximum StrengthL&R Distributors, Inc.
Flu HbpWALGREEN CO.
Flu Hbp Maxium StrengthChain Drug Marketing Association Inc
Flu Relief ChildrensTOP CARE (Topco Associates LLC)
FluactPharmaline Incorporated
Formule 115 DMFrega Inc.
Fulton Street Market ColdAccess Business Group LLC
Ganmaoling 999Kingsway Trading
GencontussKramer Novis
Good Neighbor Pharmacy Allergy Multi SymptomAmerisource Bergen
Good Neighbor Pharmacy ColdAmerisource Bergen
Good Neighbor Pharmacy Cold and Allergy PEAmerisource Bergen
Good Neighbor Pharmacy Cold Head CongestionAmerisource Bergen
Good Neighbor Pharmacy Cold Plus Multi SymptomAmerisource Bergen
Good Neighbor Pharmacy Sinus and Allergy PEAmerisource Bergen
Good Neighbor Pharmacy Sinus Congestion and PainAmerisource Bergen
Good Sense Allergy Multi SymptomL. Perrigo Company
Good Sense ColdL Perrigo Company
Good Sense Cold and AllergyL Perrigo Company
Good Sense Sinus and Allergy PEL Perrigo Company
Grippalin & C TabDistributions Multi Pro Inc.
Grippe Extra Fort NuitTherapharma Inc.
HanshinnocolHan Kook Shin Yak Pharmaceutical Co., Ltd.
Head Congestion Cold ReliefWoonsocket Prescription Center, Incorporated
Health Mart Multi Symptom Fever and Cold ChildrensDZA Brands LLC
Healthy Accents Allergy Multi SymptomDZA Brands LLC
Healthy Accents Cold Head CongestionDZA Brands LLC
Healthy Accents Multi Symptom ColdDZA Brands LLC
High Blood Pressure Cold and FluBedrock Brands, Llc
Hot Lemon Night Time Total Extra StrengthPharmetics (2011) Inc
Hot Lemon Relief for Sore Throat and Cough Extra StrengthJamp Pharma Corporation
Hot Lemon Relief for Symptoms Of Cough, Cold and FluPatheon Laboratories
Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Extra StrengthPharmetics (2011) Inc
Hybrid CFHybrid Rx Llc
Hydrocodone Bitartrate and Chlorpheniramine Maleate SolutionTris Pharma Inc
Hydrocodone Bitartrate, Chlorpheniramine Maleate and Pseudoephedrine HydrochloridePaddock Laboratories, LLC
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine HClCypress Pharmaceutical, Inc.
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine Hydrochloride Oral SolutionTris Pharma Inc
Hydrocodone Polistirex and Chlorpheniramine PolisitrexAtlantic Biologicals Corps
Hydrocodone Polistirex and Chlorpheniramine PolistirexPhysicians Total Care, Inc.
Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-releaseAristos Phamaceuticals, Inc.
Hydrocodone Polistirex and Chlorpheniramine Polistirex PennkineticAtlantic Biologicals Corps
Infants Tylenol Cold Suspension DropsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Jack & Jill Children's Formula Cough LiquidThe Buckley's Company
Jack & Jill CompleteThe Buckley's Company
Jack & Jill Cough and ColdThe Buckley's Company
Jack & Jill Cough, Cold & Flu Junior Strength TabletsThe Buckley's Company
Junior Strength Cold DM - TabletVita Health Products Inc
Junior Strength Tylenol Cold and CoughMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Junior Strength Tylenol Complete Cold, Cough & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Kgs Allergy SoothingKingsway
Kidkare Cough/coldRugby Laboratories, Inc.
Kirkland Signature ColdCostco Wholesale Company
Leader Allergy Multi SymptomCardinal Health
Leader Cold and AllergyCardinal Health
Leader Cold Head CongestionCardinal Health
Leader Sinus and Allergy PECardinal Health
Lexuss 210Centurion Labs
Lil Drug Store Allergy Sinus ReliefLil' Drug Store Products, Inc.
Lohist DLarken Laboratories, Inc.
M-end DMR.A. Mc Neil Company
Maux De Gorge Et De LA Toux Extra-fortPharmalab Inc.
Maximum Strength Allergy SinusWALGREEN CO.
Maximum Strength FluRite Aid
Maximum Strength Flu HbpDolgencorp, LLC
Medicament Pour Le Rhume, NuitLaboratoire Riva Inc
Medique Medicidin DUnifirst First Aid Corporation
Medique Onset ForteUnifirst First Aid Corporation
Members Mark AllergySam's West Inc
Metreton TabSchering Plough Canada Inc
Multi Symptom Cold ChildrensKroger Company
Multi Symptom Cold Childrens PlusQUALITY CHOICE (Chain Drug Marketing Association)
Multi Symptom Cold Plus ChildrensWestern Family Foods Inc
Multi Symptom Cold Plus Childrens Pain ReliefHy Vee Inc
Multi Symptom Cold Relief ChildrensCVS Pharmacy
Multi Symptom Fever and Cold ChildrensHy Vee Inc
Multi-symptom AllergyWALGREEN CO.
Multi-symptom ColdVALUE MERCHANDISERS COMPANY, INC.
Multi-symptom Cold ReliefWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Nasal + Sinus Cold FormulaVita Health Products Inc
Neo DM Drops DMLaser Pharmaceuticals, LLC
Neo Tuss SyrNeolab Inc
Neocitran Cough & Cold SyrupNovartis Consumer Health Canada Inc.
Night Time Cold Multi-symptomDolgencorp, LLC
Night Time Sinus Congestion and PainKroger Company
Night Time Total Extra StrengthPharmetics (2011) Inc
Nighttime ColdPublix Super Markets Inc
Nighttime Cold Head CongestionFRED'S, INC.
Nighttime Cold Relief Extra Strength TabletsPharmetics (2011) Inc
Nighttime Cold Relief Extra Strength Tablets PEPharmetics (2011) Inc
Nighttime Extra Strength Contac Cold & Sore ThroatValeant Canada Lp Valeant Canada S.E.C.
Nighttime Extra Strength Contac Complete Cough, Cold & FluValeant Canada Lp Valeant Canada S.E.C.
Nighttime Extra Strength Contac Complete Cough, Cold & Flu Plus Vitamin CGlaxosmithkline Consumer Healthcare Inc.
Nighttime Multi-symptom ColdWALGREEN CO.
Nighttime Regular Strength Contac Cold Nasal CongestionGlaxosmithkline Consumer Healthcare Inc.
Nighttime Total Super StrengthThe Winning Combination Inc.
Nite Time (children's)Perrigo International
Nitetime Cold Relief Extra StrengthJamp Pharma Corporation
Nohist DMLarken Laboratories, Inc.
Nohist LqLarken Laboratories, Inc.
Norel AdUs Pharmaceutical Corporation
Norelcs CsUs Pharmaceutical Corporation
Once-A-day Benylin Cold CapKv Pharmaceutical Company
Ornade AF LiquidSmithkline Beecham Pharma Division Of Smithkline Beecham Inc
Ornade AF Spansule SrcSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade DM 10 LiqSmithkline Beecham Pharma Division Of Smithkline Beecham Inc
Ornade DM 15 LiqSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade DM 30 LiqSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade Expectorant Cough FormulaSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade LiquidSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade Spansule SrcSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Otis Clapp ValihistUnifirst First Aid Corporation
Pain & Fever + ColdAccudial Pharmaceutical Inc
Pain & Fever + Cold & CoughAccudial Pharmaceutical Inc
Pain Relief PlusMeijer Distribution Inc
Pain Reliever Fever ReducerVelocity Pharma
Pancold SKafus Co., Ltd
Panto ASAMSUNG PHARM IND. CO., LTD.
Panto FluSAMSUNG PHARM IND. CO., LTD.
Pedia ReliefMajor Pharmaceuticals, Inc
Pediacare Childrens Plus Cough and Runny NoseBlacksmith Brands, Inc.
Pediacare Childrens Plus FluBlacksmith Brands, Inc.
Pediacare Childrens Plus Multisymptom ColdBlacksmith Brands, Inc.
Pediatric Cough and Cold MedicineSilarx Pharmaceuticals, Inc
Pentuss SrsRhone Poulenc Rorer Canada Inc.
Phenylhistine DhQualitest Pharmaceuticals
Physicianscare Allergy Multi-symptom ReliefAcme United Corporation
Plus Multi Symptom Cold Childrens Pain ReliefHannaford Brothers Company
Poly Hist PdPoly Pharmaceuticals, Inc.
Poly-tussin DMPoly Pharmaceuticals, Inc.
Prime's Sore Throat, Cough and Colds CapsulesPrime Health Ltd.
Pseudoephedrine PlusContract Pharmacal Corp
Quality Choice Effervescent Cold Relief PlusChain Drug Marketing Association
R-tannaPd Rx Pharmaceuticals, Inc.
R-tanna Pediatric SuspensionPrasco Laboratories
Rapid Release Multi-symptom Allergy ReliefWal Mart Stores Inc
Reg.str.cold Medic.(night Time Relief)capletWestcan Pharmaceuticals Ltd.
Regular Strength Tylenol Cold and Flu PowderMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Regular Strength Tylenol Cold NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Regular Strength Tylenol Cold Nighttime CapletMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Relief-PENor Med
Relievol Allergy Sinus Caplets Extra StrengthTanta Pharmaceuticals Inc
Rescon DMCapellon Pharmaceuticals, LLC
Rhume Extra Fort NuitTherapharma Inc.
Robitussin Peak Cold Nighttime Nasal ReliefRichmond Division of Wyeth
Robitussin Total Cough, Cold & Flu Extra StrengthPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Rx Act Sinus and Allergy PEH E B
Rycontuss Cherry FlavorOkendpharma, Inc.
Sanatos Cold Multi-symptomPharmadel LLC
Scot-tussin DM Maximum Strength Cough Suppressant and Cold ReliefIri Sys, Llc
Scot-tussin DM Sf Maximum Strength Cough ColdScot Tussin Pharmacal Co., Inc.
Shoprite AllergyWakefern Food Corporation
Shoprite Childrens Multi Symptom Cold ReliefWakefern Food Corporation
Sildec PE DMRebel Distributors Corp
Sine Off Sinus/cold MedicineGemini Pharmaceuticals, Inc.
Sine-off Allergy TabSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Sinus and AllergyL&R Distributors, Inc.
Sinus and Allergy Maximum StrengthWestern Family Foods Inc
Sinus and Allergy PESafeway
Sinus and Allergy PE Maximum StrengthKroger Company
Sinus and Allergy Regular StrengthPharmetics (2011) Inc
Sinus and Allergy Releif PEP And L Development Of New York Corporation (Ready In Case)
Sinus and Allergy ReliefSafeway
Sinus and Allergy Relief PERite Aid
Sinus Congestion and PainL&R Distributors, Inc.
Sinus Congestion and Pain Daytime NighttimeAAA Pharmaceutical, Inc.
Sinus Congestion and Pain NighttimeFRED'S, INC.
Sinus Extra Fort NuitTherapharma Inc.
Sinus Nighttime Extra Strength CapletsPharmetics (2011) Inc
Sinus Pain and Congestion NighttimeWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Sinus PE Plus Allergy Maximum StrengthWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Sinus Plus Allergy PE Maximum StrengthSUPERVALU INC.
Sinus Ultra Strength TabletJamp Pharma Corporation
Sinusales Extra Fort NuitProdemdis Enr.
Sinutab Extra Strength TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab PE Extra StrengthMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab PE NightimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab Regular Strength TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab With Codeine TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Smart Sense Childrens Multi Symptom Cold ReliefKmart Corporation
Smart Sense Multi Symptom ColdKmart Corporation
Smart Sense Multi Symptom Fever and Cold ChildrensKmart Corporation
Sohmed Allergy SinusSOHM Inc.
Sore Throat & Cough Ultra StrengthPharmascience Inc
StonaSato Pharmaceutical Co., Ltd.
Stona for ChildrenSato Pharmaceutical Co., Ltd.
Stona-SSato Pharmaceutical Co., Ltd.
StonarhiniSato Pharmaceutical Co., Ltd.
Sudafed Sinus & AllergyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
SudogestMajor Pharmaceuticals
Sunmark Allergy Multi SymptomMc Kesson
Sunmark ColdMc Kesson
Sunmark Cold and AllergyMc Kesson
Sunmark Sinus and Allergy PE Maximum StrengthMc Kesson
Suphedrine PEWal Mart Stores Inc
Suphedrine PE Sinus Plus AllergyArmy and Air Force Exchange Service
Tabcin 500Salimex, S.A.
Theraflu Flu Cold and Cough MedicineSandoz Canada Inc
Theraflu Warming Relief Nighttime Multi-symptom Cold CapletsNovartis Consumer Health, Inc.
Topcare Allergy Multi SymptomTopco Associates LLC
Topcare ColdTopco Associates LLC
Topcare Cold and AllergyTopco Associates LLC
Topcare Cold Head Congestion NighttimeTopco Associates LLC
Topcare Cold Nighttime Multi SymptomTopco Associates LLC
Topcare Sinus and Allergy PE Maximum StrengthTopco Associates LLC
Topcare Sinus Congestion and PainTopco Associates LLC
Total FluPharmetics (2011) Inc
Toux Rhume Et Grippe (extra-fort)Prodemdis Enr.
Triaminic Childrens Cold and AllergyNovartis Consumer Health, Inc.
Triaminic Cold & Nighttime CoughNovartis Consumer Health Canada Inc.
Triaminic Cold and AllergyNovartis Consumer Health Canada Inc.
Triaminic Cold and Allergy SyrupNovartis Consumer Health Canada Inc.
Triaminic Cold and CoughNovartis Consumer Health Canada Inc.
Triaminic Cold Cough and FeverNovartis Consumer Health Canada Inc.
Triaminic DM Expectorant SyrNovartis Consumer Health Canada Inc.
Triaminic Expectorant SyrNovartis Consumer Health Canada Inc.
Triaminic Multi-symptom FeverNovartis Consumer Health, Inc.
Triaminic Multi-symptom Fever and ColdNovartis Consumer Health, Inc.
Triaminic Softchews Cold and AllergyNovartis Consumer Health Canada Inc.
Triaminic Softchews Cough and ColdNovartis Consumer Health Canada Inc.
Triaminic Total Cold With Cough & Fever ReliefNovartis Consumer Health Canada Inc.
Triaminicol DM SyrupNovartis Consumer Health Canada Inc.
Tricode ArRespa Pharmaceuticals, Inc.
TussicapsECR Pharmaceuticals
Tussilyn DMLes Laboratoires Vachon Inc.
Tussionex PennkineticUnither Manufacturing, LLC
Tuzistra XRVernalis Therapeutics, Inc.
Tylenol AllergyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Cold Nightime Rapid ReleaseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Sinus NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Ultra Strength Neocitran Flu NightNovartis Consumer Health Canada Inc.
Up and Up Childrens Multi Symptom Cold Pain Relief PlusTarget Corporation
VasofrinicLaboratoires Trianon Inc
Vasofrinic DhLaboratoires Trianon Inc
Vasofrinic Plus SiropLaboratoires Trianon Inc
Vasofrinic SiropLaboratoires Trianon Inc
Vicks Alcohol Free Nyquil Cold and Flu Nighttime ReliefProcter & Gamble Manufacturing Company
Vicks Children's Nyquil Cold & Cough Multi-symptom ReliefProcter & Gamble Inc
Vicks Childrens Nyquil Cold and Cough Multi-symptom ReliefThe Procter & Gamble Manufacturing Company
Vicks Custom Care Cough & Cold PMProcter & Gamble Inc
Vicks Formula 44m LiqProcter & Gamble Inc
Vicks Nyquil Cold and Flu Nighttime Relief and Vicks Childrens Nyquil Cold and CoughThe Procter & Gamble Manufacturing Company
Vicks Pediatric Formula 44m LiqProcter & Gamble Inc
VituzHawthorn Pharmaceuticals, Inc.
Wal-finate DWALGREEN CO.
Wal-phedWALGREEN CO.
Wal-phed PEWALGREEN CO.
Winco Foods Effervescent Cold ReliefWin Co Foods, Llc
Xl3 XtraTeresa Cecena Dba Genesis
YinchiaoTianjin Zhongxin Pharmaceutical Group Corp Ltd Longshunrong Pharmaceutical Factory
Z-tuss AcMagna Pharmaceuticals, Inc.
Zodryl Ac 25Coda Dose, Inc.
Zodryl Ac 30Coda Dose, Inc.
Zodryl Ac 40Coda Dose, Inc.
Zodryl Ac 50Coda Dose, Inc.
Zodryl Ac 60Coda Dose, Inc.
Zodryl Ac 80Coda Dose, Inc.
ZutriproHawthorn Pharmaceuticals, Inc.
Salts
Name/CASStructureProperties
Chlorpheniramine maleate
ThumbNot applicableDBSALT000987
Chlorpheniramine polistirex
ThumbNot applicableDBSALT001601
Chlorpheniramine tannate
ThumbNot applicableDBSALT001556
Categories
CAS number132-22-9
WeightAverage: 274.788
Monoisotopic: 274.123676325
Chemical FormulaC16H19ClN2
InChI KeyInChIKey=SOYKEARSMXGVTM-UHFFFAOYSA-N
InChI
InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
IUPAC Name
[3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
SMILES
CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pheniramines. These are compounds containing a pheniramine moiety, which is structurally characterized by the presence of a 2-benzylpyridine linked to an dimethyl(propyl)amine to form a dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine skeleton.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPheniramines
Direct ParentPheniramines
Alternative Parents
Substituents
  • Pheniramine
  • Phenylpropylamine
  • Aralkylamine
  • Halobenzene
  • Chlorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.
PharmacodynamicsIn allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Mechanism of actionChlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
AbsorptionWell absorbed in the gastrointestinal tract.
Volume of distributionNot Available
Protein binding72%
Metabolism

Primarily hepatic via Cytochrome P450 (CYP450) enzymes.

Route of eliminationNot Available
Half life21-27 hours
ClearanceNot Available
ToxicityOral LD50 (rat): 306 mg/kg; Oral LD50 (mice): 130 mg/kg; Oral LD50 (guinea pig): 198 mg/kg [Registry of Toxic Effects of Chemical Substances. Ed. D. Sweet, US Dept. of Health & Human Services: Cincinatti, 2010.] Also a mild reproductive toxin to women of childbearing age.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9754
Blood Brain Barrier+0.962
Caco-2 permeable+0.8749
P-glycoprotein substrateSubstrate0.6136
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.9376
Renal organic cation transporterInhibitor0.7916
CYP450 2C9 substrateNon-substrate0.8026
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.6472
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9096
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9023
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7501
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9183
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.3361 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8702
hERG inhibition (predictor II)Inhibitor0.7145
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Granuleoral
Capsule, gelatin coatedoral
Capsule, liquid filledoral
Tablet, effervescentoral
Granule, effervescentoral
Powder, for solutionoral
Syruporal2 mg/5mL
Liquid; tabletintramuscular; oral; subcutaneous
Liquid; tabletoral; parenteral (unspecified)
Granule, for solutionoral
Tablet, chewableoral
Liquidoral
Solutionoral
Tablet, extended releaseoral12 mg/1
Tablet (extended-release)oral12 mg
Tabletoral12 mg
Tablet, film coated, extended releaseoral12 mg/1
Tablet4 mg
Liquidintramuscular; intravenous; subcutaneous10 mg
Syruporal2.5 mg
Tablet, extended releaseoral
Tablet (extended-release)oral
Kit
Tablet, sugar coatedoral
Lozengeoral2 mg/1
Liquidoral2 mL/mL
Liquidoral2 mg/5mL
Tablet, coatedoral4 mg/1
Package; powderoral
Tabletoral4 mg/1
Tablet, film coatedoral
Capsuleoral1.25 mg/1
Suspension, extended releaseoral
Tablet (chewable)oral
Capsule, delayed release pelletsoral
Capsuleoral
Tablet, multilayeroral
Tabletoral4 mg
Capsule (sustained-release)oral
Powderoral
Syrup (extended-release)oral
Tabletoral
Powder for solutionoral
Tablet, coatedoral
Syruporal
Suspensionoral
Capsule, extended releaseoral
Prices
Unit descriptionCostUnit
Ahist 12 mg tablet1.1USD tablet
Myci chlor-tan 8 mg caplet0.75USD caplet
Chlorpheniramine powder0.67USD g
Chlor-trimeton allergy0.31USD each
Chlor-trimeton 8 mg repetab0.24USD tablet
Aller-chlor 4 mg tablet0.06USD tablet
Pediacare allergy solution0.05USD ml
Allergy 4 mg tablet0.04USD tablet
Chlorpheniramine 4 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateLiquid
Experimental Properties
PropertyValueSource
boiling point142 °CNot Available
water solubility5500 mg/L (at 37 °C)BEILSTEIN
logP3.38HANSCH,C ET AL. (1995)
pKa9.13 (at 25 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
Water Solubility0.0519 mg/mLALOGPS
logP3.74ALOGPS
logP3.58ChemAxon
logS-3.7ALOGPS
pKa (Strongest Basic)9.47ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area16.13 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity80.85 m3·mol-1ChemAxon
Polarizability30.82 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-ez00000000-ea4ccfd2afe05f49fc7aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-00z0000000-9e46eb080de95d4f8f8eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-4za0000000-d2d2acf559d9070a1d47View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (Unknown) , Positivesplash10-n7z0000000-2ca3230cde716588805eView in MoNA
MSMass Spectrum (Electron Ionization)splash10-qfz0000000-8e58cd1c686f23a7dac6View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Anil M. Salpekar, John Johnson, “Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom.” U.S. Patent US4631284, issued April, 1975.

US4631284
General References
External Links
ATC CodesR06AB04
AHFS Codes
  • 04:04.20
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (72.8 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Chlorphenamine can be increased when it is combined with Abiraterone.
AcepromazineAcepromazine may increase the hypotensive activities of Chlorphenamine.
AcetazolamideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Acetazolamide.
AclidiniumAclidinium may increase the anticholinergic activities of Chlorphenamine.
AmilorideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Amiloride.
AmphetamineAmphetamine may decrease the sedative activities of Chlorphenamine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Chlorphenamine.
AzelastineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Chlorphenamine.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Bendroflumethiazide.
Benzylpenicilloyl PolylysineChlorphenamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Chlorphenamine.
Botulinum Toxin Type AChlorphenamine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BChlorphenamine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
BumetanideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Bumetanide.
BuprenorphineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
ButorphanolButorphanol may decrease the analgesic activities of Chlorphenamine.
CathinoneCathinone may decrease the sedative activities of Chlorphenamine.
ChlorothiazideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Chlorothiazide.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Chlorthalidone.
Cimetropium BromideChlorphenamine may increase the anticholinergic activities of Cimetropium Bromide.
CobicistatThe serum concentration of Chlorphenamine can be increased when it is combined with Cobicistat.
CyclothiazideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Cyclothiazide.
DarunavirThe serum concentration of Chlorphenamine can be increased when it is combined with Darunavir.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
EluxadolineChlorphenamine may increase the activities of Eluxadoline.
Ethacrynic acidThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ethacrynic acid.
EthanolChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthoxzolamideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ethoxzolamide.
FluoxetineThe metabolism of Chlorphenamine can be decreased when combined with Fluoxetine.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Chlorphenamine.
FurosemideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Furosemide.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Glucagon recombinant.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Chlorphenamine.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Hydrochlorothiazide.
HydrocodoneChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Hydroflumethiazide.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
IndapamideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Indapamide.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Chlorphenamine.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Chlorphenamine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorphenamine.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
MethotrimeprazineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetolazoneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Metolazone.
MetyrosineChlorphenamine may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Chlorphenamine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
MirabegronThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Mirabegron.
MirtazapineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MorphineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
OctreotideThe metabolism of Chlorphenamine can be decreased when combined with Octreotide.
OrphenadrineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
PanobinostatThe serum concentration of Chlorphenamine can be increased when it is combined with Panobinostat.
ParaldehydeChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Paroxetine.
Peginterferon alfa-2bThe serum concentration of Chlorphenamine can be decreased when it is combined with Peginterferon alfa-2b.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Chlorphenamine.
Potassium ChlorideChlorphenamine may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleChlorphenamine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Chlorphenamine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Chlorphenamine.
RamosetronChlorphenamine may increase the activities of Ramosetron.
RitonavirThe metabolism of Chlorphenamine can be decreased when combined with Ritonavir.
RopiniroleChlorphenamine may increase the sedative activities of Ropinirole.
RotigotineChlorphenamine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chlorphenamine.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Chlorphenamine.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
SpironolactoneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Spironolactone.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Chlorphenamine.
SuvorexantChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Chlorphenamine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
ThalidomideChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThioridazineChlorphenamine may increase the arrhythmogenic activities of Thioridazine.
TiclopidineThe metabolism of Chlorphenamine can be decreased when combined with Ticlopidine.
TicrynafenThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ticrynafen.
TiotropiumChlorphenamine may increase the anticholinergic activities of Tiotropium.
TopiramateThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Topiramate.
TorasemideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Torasemide.
TriamtereneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Triamterene.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Chlorphenamine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Chlorphenamine.
ZolpidemChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Avoid alcohol.
  • Take with food.

Targets

1. Histamine H1 receptor

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Histamine H1 receptor P35367 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Iwata R, Fujii T, Komemushi S, Ido T, Itoh M, Sasaki H, Watanabe T, Yanai K: Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine. Br J Clin Pharmacol. 2001 Nov;52(5):501-9. Pubmed
  3. Salata JJ, Jurkiewicz NK, Wallace AA, Stupienski RF 3rd, Guinosso PJ Jr, Lynch JJ Jr: Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circ Res. 1995 Jan;76(1):110-9. Pubmed
  4. Hasenohrl RU, Kuhlen A, Frisch C, Galosi R, Brandao ML, Huston JP: Comparison of intra-accumbens injection of histamine with histamine H1-receptor antagonist chlorpheniramine in effects on reinforcement and memory parameters. Behav Brain Res. 2001 Oct 15;124(2):203-11. Pubmed
  5. Yasuda SU, Wellstein A, Likhari P, Barbey JT, Woosley RL: Chlorpheniramine plasma concentration and histamine H1-receptor occupancy. Clin Pharmacol Ther. 1995 Aug;58(2):210-20. Pubmed
  6. Nicholson AN, Pascoe PA, Turner C, Ganellin CR, Greengrass PM, Casy AF, Mercer AD: Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene. Br J Pharmacol. 1991 Sep;104(1):270-6. Pubmed

2. Sodium-dependent serotonin transporter

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent serotonin transporter P31645 Details

References:

  1. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. Pubmed

3. Sodium-dependent noradrenaline transporter

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent noradrenaline transporter P23975 Details

References:

  1. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. Pubmed

4. Sodium-dependent dopamine transporter

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent dopamine transporter Q01959 Details

References:

  1. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. Pubmed

Enzymes

1. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.

2. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. Pubmed
  2. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 3A5

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A5 P20815 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.

4. Cytochrome P450 3A7

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A7 P24462 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.

Transporters

1. Solute carrier family 22 member 2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 2 O15244 Details

References:

  1. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. Pubmed

2. Solute carrier family 22 member 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 1 O15245 Details

References:

  1. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on December 03, 2015 13:41