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Identification
NameChlormezanone
Accession NumberDB01178  (APRD00865)
TypeSmall Molecule
GroupsApproved, Withdrawn
DescriptionA non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. [PubChem]
Structure
Thumb
Synonyms
(+-)-Chlormezanone
(±)-chlormezanone
2-(P-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
2-(P-Chlorphenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide
Chlormethazanone
Chlormezanona
Chlormezanone
Chlormezanonum
Clormezanona
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
FenaprimNot Available
TrancopalWinthropSreon
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIGP568V9G19
CAS number80-77-3
WeightAverage: 273.736
Monoisotopic: 273.022641652
Chemical FormulaC11H12ClNO3S
InChI KeyInChIKey=WEQAYVWKMWHEJO-UHFFFAOYSA-N
InChI
InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3
IUPAC Name
2-(4-chlorophenyl)-3-methyl-1λ⁶,3-thiazinane-1,1,4-trione
SMILES
CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as chlorobenzenes. These are compounds containing one or more chlorine atoms attached to a benzene moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassHalobenzenes
Direct ParentChlorobenzenes
Alternative Parents
Substituents
  • Chlorobenzene
  • 1,3-thiazinane
  • Aryl halide
  • Aryl chloride
  • Tertiary carboxylic acid amide
  • Sulfone
  • Tertiary amine
  • Lactam
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationUsed in the management of anxiety and in the treatment of muscle spasm.
PharmacodynamicsChlormezanone is a non-benzodiazepine muscle relaxant. It was discontinued worldwide in 1996 by its manufacturer due to confirmed serious and rare cutaneous reactions (toxic epidermal necrolysis).
Mechanism of actionChlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicitySymptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9167
Blood Brain Barrier+0.9383
Caco-2 permeable-0.5597
P-glycoprotein substrateNon-substrate0.6347
P-glycoprotein inhibitor INon-inhibitor0.6885
P-glycoprotein inhibitor IINon-inhibitor0.9959
Renal organic cation transporterNon-inhibitor0.7164
CYP450 2C9 substrateNon-substrate0.6022
CYP450 2D6 substrateNon-substrate0.7983
CYP450 3A4 substrateSubstrate0.6616
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9375
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5186
Ames testNon AMES toxic0.6263
CarcinogenicityNon-carcinogens0.7622
BiodegradationNot ready biodegradable0.6329
Rat acute toxicity2.6246 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9892
hERG inhibition (predictor II)Non-inhibitor0.7018
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point116.2-118.6Merck Index 2072
water solubility2500 mg/L (at 25 °C)MERCK INDEX (1996)
logP1.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.61 mg/mLALOGPS
logP0.84ALOGPS
logP0.92ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)19.07ChemAxon
pKa (Strongest Basic)-2.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area54.45 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity64.88 m3·mol-1ChemAxon
Polarizability25.89 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0udi-7900000000-6c729f1a3c9cb4241b45View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
References
Synthesis ReferenceNot Available
General References
  1. Wollina U, Hipler UC, Seeling A, Oelschlager H: Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro. Skin Pharmacol Physiol. 2005 May-Jun;18(3):132-8. [PubMed:15897685 ]
  2. Seeling A, Oelschlager H, Rothley D: [Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone]. Pharmazie. 2000 Apr;55(4):293-6. [PubMed:10798243 ]
  3. Oelschlager H, Klinger W, Rothley D, Seeling A, Bockhard H, Hofmann B, Machts H, Riederer H, Rackur H: [Cleavage and biotransformation of the central muscle relaxant chlormezanone]. Pharmazie. 1998 Sep;53(9):620-4. [PubMed:9770210 ]
  4. Gautier V, Vincon G, Demotes-Mainard F, Albin H: [Pharmacokinetics of chlormezanone in healthy volunteers]. Therapie. 1990 Jul-Aug;45(4):315-9. [PubMed:2399514 ]
External Links
ATC CodesM03BB02M03BB72M03BB52
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when Chlormezanone is combined with 7-Nitroindazole.
AcepromazineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Chlormezanone is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlormezanone.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlormezanone.
AmisulprideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Amitriptyline.
AmobarbitalThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Amobarbital.
AmoxapineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Amperozide.
AripiprazoleThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Aripiprazole.
ArticaineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Asenapine.
AzaperoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Azaperone.
AzelastineChlormezanone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Chlormezanone.
BaclofenThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Barbital.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chlormezanone.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Benzyl alcohol.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
BrimonidineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlormezanone.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Chlormezanone.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Chlormezanone.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Chlormezanone.
ButacaineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Butethal.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Chlormezanone.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Chlormezanone.
CarbinoxamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Chlormezanone.
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Chlormezanone.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Chlormezanone.
CitalopramThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Chlormezanone is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Chlormezanone.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Chlormezanone.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Chlormezanone.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chlormezanone.
CyclizineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chlormezanone.
CyproheptadineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Chlormezanone.
DapoxetineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dapoxetine.
deramciclaneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Desflurane.
DesipramineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Chlormezanone.
DextromoramideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlormezanone.
DezocineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dezocine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Chlormezanone.
DifenoxinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chlormezanone.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Chlormezanone.
DoramectinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
DoxylamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Chlormezanone is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Chlormezanone.
DrotebanolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Chlormezanone.
EcgonineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Chlormezanone is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Efavirenz.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Chlormezanone.
EntacaponeThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Entacapone.
EscitalopramThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Estazolam.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Chlormezanone.
EthanolChlormezanone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Chlormezanone.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chlormezanone.
EthosuximideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Chlormezanone.
EtoperidoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Etorphine.
EzogabineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Chlormezanone.
FexofenadineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Flunitrazepam.
FluoxetineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Chlormezanone.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Chlormezanone.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Chlormezanone.
FluspirileneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fospropofol.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Chlormezanone.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Chlormezanone is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Gamma Hydroxybutyric Acid.
GlutethimideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Glutethimide.
GuanfacineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Chlormezanone.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Chlormezanone.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Chlormezanone.
HeroinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Heroin.
HexobarbitalThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Hexobarbital.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Chlormezanone.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chlormezanone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
HydroxyzineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Indalpine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Chlormezanone.
KetamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ketobemidone.
LamotrigineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Chlormezanone.
LevocabastineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Levomethadyl Acetate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Chlormezanone.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlormezanone.
LithiumThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlormezanone.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Chlormezanone.
Lu AA21004The risk or severity of adverse effects can be increased when Chlormezanone is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Chlormezanone.
MelperoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Chlormezanone.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Chlormezanone.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Chlormezanone.
MetaxaloneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Chlormezanone.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Chlormezanone.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Chlormezanone.
MethsuximideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Chlormezanone.
MetyrosineChlormezanone may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Chlormezanone.
MilnacipranThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
MirtazapineChlormezanone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Chlormezanone.
MolindoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chlormezanone.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
NabiloneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Nabilone.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Chlormezanone.
NitrazepamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Chlormezanone.
OpiumThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Opium.
OrphenadrineChlormezanone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Chlormezanone.
OsanetantThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Chlormezanone.
OxprenololThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Chlormezanone.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlormezanone.
OxymorphoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Oxymorphone.
PaliperidoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Paliperidone.
ParaldehydeChlormezanone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Chlormezanone.
ParoxetineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Chlormezanone.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Chlormezanone.
PerampanelThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Chlormezanone.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chlormezanone.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Chlormezanone.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Phenoxyethanol.
PhenytoinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Chlormezanone.
PipamperoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Pomalidomide.
PramipexoleChlormezanone may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlormezanone.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chlormezanone.
PrimidoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Chlormezanone.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chlormezanone.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Chlormezanone.
PromethazineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chlormezanone.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Chlormezanone.
PropoxycaineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Chlormezanone is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Quetiapine.
RamelteonThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ramelteon.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Chlormezanone.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Chlormezanone.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Chlormezanone.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Chlormezanone.
RomifidineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Romifidine.
RopiniroleChlormezanone may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chlormezanone.
RotigotineChlormezanone may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chlormezanone.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Chlormezanone is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Chlormezanone.
SertindoleThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Sevoflurane.
Sodium oxybateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Sodium oxybate.
StiripentolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Chlormezanone.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Chlormezanone.
SuvorexantThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tasimelteon.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Chlormezanone.
TetrabenazineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tetrodotoxin.
ThalidomideChlormezanone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Chlormezanone.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Chlormezanone.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Chlormezanone.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Chlormezanone.
ThiothixeneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tiletamine.
TizanidineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chlormezanone.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Chlormezanone.
TrazodoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Chlormezanone.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Chlormezanone.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Chlormezanone.
TrimipramineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Chlormezanone.
VigabatrinThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Vilazodone.
VortioxetineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Xylazine.
YohimbineThe therapeutic efficacy of Chlormezanone can be decreased when used in combination with Yohimbine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Chlormezanone.
ZiconotideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Chlormezanone.
ZolazepamThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Chlormezanone.
ZonisamideThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Cholesterol binding
Specific Function:
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benz...
Gene Name:
TSPO
Uniprot ID:
P30536
Molecular Weight:
18827.81 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23