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Identification
NameDezocine
Accession NumberDB01209  (APRD00912)
TypeSmall Molecule
GroupsApproved
DescriptionDezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.
Structure
Thumb
Synonyms
(-)-13beta-amino-5,6,7,8,9,10,11alpha,12-Octahydro-5alpha-methyl-5,11-methanobenzocyclodecen-3-ol
Dezocina
Dezocinum
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
DalganNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIVHX8K5SV4X
CAS number53648-55-8
WeightAverage: 245.3599
Monoisotopic: 245.177964363
Chemical FormulaC16H23NO
InChI KeyInChIKey=VTMVHDZWSFQSQP-VBNZEHGJSA-N
InChI
InChI=1S/C16H23NO/c1-16-8-4-2-3-5-12(15(16)17)9-11-6-7-13(18)10-14(11)16/h6-7,10,12,15,18H,2-5,8-9,17H2,1H3/t12-,15-,16+/m0/s1
IUPAC Name
(1R,9S,15S)-15-amino-1-methyltricyclo[7.5.1.0²,⁷]pentadeca-2,4,6-trien-4-ol
SMILES
[H][C@@]12CC3=CC=C(O)C=C3[C@@](C)(CCCCC1)[[email protected]]2N
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tetralins. These are polycyclic aromatic compounds containing a tetralin moiety, which consists of a benzene fused to a cyclohexane.
KingdomOrganic compounds
Super ClassBenzenoids
ClassTetralins
Sub ClassNot Available
Direct ParentTetralins
Alternative Parents
Substituents
  • Tetralin
  • Aralkylamine
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Amine
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationIndicated in the treatment of moderate to severe pain.
PharmacodynamicsDezocine is a parenteral narcotic analgesic possessing both agonist and antagonist activity. It is similar to morphine with respect to analgesic potency and onset and duration of action. The narcotic antagonist activity is greater than that of pentazocine.
Mechanism of actionDezocine is a opioid analgesic drug of mixed agonist-antagonist type. It binds with stereospecific receptors at many sites within the central nervous system (CNS) to alter processes affecting both the perception of pain and the emotional response to pain. At least 2 of these types of receptors (mu and kappa) mediate analgesia. Mu receptors are widely distributed throughout the CNS, especially in the limbic system (frontal cortex, temporal cortex, amygdala, and hippocampus), thalamus, striatum, hypothalamus, and midbrain as well as laminae I, II, IV, and V of the dorsal horn in the spinal cord. Kappa receptors are localized primarily in the spinal cord and in the cerebral cortex.
Related Articles
AbsorptionRapid and complete following intramuscular administration.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic, via conjugation (glucuronidation).

Route of eliminationNot Available
Half lifeElimination half-life following intramuscular administration averages 2.2 hours. Elimination half-life following a 5mg intravenous dose averages 1.7 to 2.6 hours (range 0.6 to 4.4 hours) while a 10mg dose averages 2.4 to 2.6 hours (range 1.2 to 7.4 hours). In patients with hepatic cirrhosis, the half-life is increased by 30 to 50%.
ClearanceNot Available
ToxicitySymptoms of overdose include cold and clammy skin, confusion, nervousness, or severe restlessness, convulsions (seizures), severe dizziness, severe drowsiness, low blood pressure, pinpoint pupils of eyes, slow heartbeat, slow or troubled breathing and severe weakness.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Dezocine Action PathwayDrug actionSMP00676
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9932
Blood Brain Barrier+0.9403
Caco-2 permeable+0.6275
P-glycoprotein substrateSubstrate0.6181
P-glycoprotein inhibitor INon-inhibitor0.9556
P-glycoprotein inhibitor IINon-inhibitor0.8905
Renal organic cation transporterNon-inhibitor0.7672
CYP450 2C9 substrateNon-substrate0.7337
CYP450 2D6 substrateNon-substrate0.6473
CYP450 3A4 substrateSubstrate0.5845
CYP450 1A2 substrateInhibitor0.5521
CYP450 2C9 inhibitorNon-inhibitor0.7985
CYP450 2D6 inhibitorNon-inhibitor0.8933
CYP450 2C19 inhibitorNon-inhibitor0.7939
CYP450 3A4 inhibitorNon-inhibitor0.7701
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5
Ames testNon AMES toxic0.7561
CarcinogenicityNon-carcinogens0.8934
BiodegradationNot ready biodegradable0.9865
Rat acute toxicity2.4549 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8997
hERG inhibition (predictor II)Inhibitor0.6053
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP3.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.014 mg/mLALOGPS
logP3.77ALOGPS
logP3.23ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)10.43ChemAxon
pKa (Strongest Basic)9.67ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area46.25 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity74.19 m3·mol-1ChemAxon
Polarizability28.49 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN02AX03
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Dezocine.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Dezocine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Dezocine is combined with 7-Nitroindazole.
AcepromazineAcepromazine may increase the hypotensive activities of Dezocine.
AcepromazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Aceprometazine.
AcetazolamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Acetazolamide.
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Dezocine.
adipiplonThe risk or severity of adverse effects can be increased when Dezocine is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Dezocine is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Dezocine is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dezocine.
AlimemazineAlimemazine may increase the hypotensive activities of Dezocine.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Dezocine is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dezocine.
AlvimopanThe risk or severity of adverse effects can be increased when Dezocine is combined with Alvimopan.
AmilorideThe risk or severity of adverse effects can be increased when Dezocine is combined with Amiloride.
AmisulprideThe risk or severity of adverse effects can be increased when Dezocine is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Dezocine is combined with Amitriptyline.
Ammonium chlorideAmmonium chloride may increase the excretion rate of Dezocine which could result in a higher serum level.
AmobarbitalThe risk or severity of adverse effects can be increased when Dezocine is combined with Amobarbital.
AmoxapineDezocine may increase the serotonergic activities of Amoxapine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Dezocine.
AmperozideThe risk or severity of adverse effects can be increased when Dezocine is combined with Amperozide.
AmphetamineAmphetamine may increase the analgesic activities of Dezocine.
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Dezocine.
AripiprazoleThe risk or severity of adverse effects can be increased when Dezocine is combined with Aripiprazole.
ArticaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Dezocine is combined with Asenapine.
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Dezocine.
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Dezocine.
AzaperoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Azaperone.
AzelastineDezocine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Dezocine.
AzosemideThe risk or severity of adverse effects can be increased when Dezocine is combined with Azosemide.
BaclofenThe risk or severity of adverse effects can be increased when Dezocine is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Dezocine is combined with Barbital.
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Dezocine.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Bendroflumethiazide.
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Dezocine.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dezocine.
BenzphetamineBenzphetamine may increase the analgesic activities of Dezocine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Dezocine is combined with Benzyl alcohol.
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Dezocine.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Dezocine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
BrimonidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Dezocine is combined with Brotizolam.
BumetanideThe risk or severity of adverse effects can be increased when Dezocine is combined with Bumetanide.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dezocine.
BuprenorphineBuprenorphine may decrease the analgesic activities of Dezocine.
BuprenorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Dezocine.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Dezocine.
ButacaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Dezocine is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Dezocine is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Dezocine is combined with Butethal.
ButorphanolButorphanol may decrease the analgesic activities of Dezocine.
ButorphanolThe risk or severity of adverse effects can be increased when Dezocine is combined with Butorphanol.
Canrenoic acidThe risk or severity of adverse effects can be increased when Dezocine is combined with Canrenoic acid.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Dezocine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Dezocine is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Dezocine is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Dezocine is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dezocine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dezocine.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Dezocine.
ChlorothiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorothiazide.
ChlorphenamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorphenamine.
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Dezocine.
ChlorphentermineChlorphentermine may increase the analgesic activities of Dezocine.
ChlorpromazineChlorpromazine may increase the hypotensive activities of Dezocine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorprothixene.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorthalidone.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Dezocine.
CitalopramDezocine may increase the serotonergic activities of Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Dezocine is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Dezocine is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Dezocine is combined with clomethiazole.
ClomipramineDezocine may increase the serotonergic activities of Clomipramine.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Dezocine.
ClonazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Dezocine.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Dezocine.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Dezocine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Dezocine.
ConivaptanThe risk or severity of adverse effects can be increased when Dezocine is combined with Conivaptan.
CyclizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dezocine.
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Dezocine.
CyclothiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Cyclothiazide.
CyproheptadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Dezocine is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Dezocine.
DapoxetineDezocine may increase the serotonergic activities of Dapoxetine.
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Dezocine.
deramciclaneThe risk or severity of adverse effects can be increased when Dezocine is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Dezocine.
DesipramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Dezocine.
DesmopressinThe risk or severity of adverse effects can be increased when Dezocine is combined with Desmopressin.
DetomidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Dexbrompheniramine.
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Dezocine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Dezocine.
DextroamphetamineDextroamphetamine may increase the analgesic activities of Dezocine.
DextromoramideThe risk or severity of adverse effects can be increased when Dezocine is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dezocine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Dezocine.
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Dezocine.
DifenoxinThe risk or severity of adverse effects can be increased when Dezocine is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dezocine is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Dezocine is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dezocine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Dezocine.
DoramectinThe risk or severity of adverse effects can be increased when Dezocine is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Dezocine is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
DoxylamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Dezocine is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Dezocine.
DrospirenoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Drospirenone.
DrotebanolThe risk or severity of adverse effects can be increased when Dezocine is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Dezocine.
EcgonineThe risk or severity of adverse effects can be increased when Dezocine is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Dezocine is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Dezocine is combined with Efavirenz.
EfonidipineThe risk or severity of adverse effects can be increased when Dezocine is combined with Efonidipine.
EluxadolineDezocine may increase the constipating activities of Eluxadoline.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Dezocine.
EntacaponeThe risk or severity of adverse effects can be increased when Dezocine is combined with Entacapone.
EplerenoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Eplerenone.
EscitalopramDezocine may increase the serotonergic activities of Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Dezocine is combined with Estazolam.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Dezocine.
Etacrynic acidThe risk or severity of adverse effects can be increased when Dezocine is combined with Etacrynic acid.
EthanolDezocine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Dezocine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Dezocine.
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Dezocine.
EthosuximideThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethotoin.
EthoxzolamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethoxzolamide.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Dezocine is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Dezocine is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Dezocine.
EtoperidoneDezocine may increase the serotonergic activities of Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Etorphine.
EzogabineThe risk or severity of adverse effects can be increased when Dezocine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Dezocine is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Fencamfamine.
FenfluramineDezocine may increase the serotonergic activities of Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Dezocine.
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Dezocine.
FexofenadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Dezocine is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Flunitrazepam.
FluoxetineDezocine may increase the serotonergic activities of Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Dezocine.
FluphenazineFluphenazine may increase the hypotensive activities of Dezocine.
FluphenazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Dezocine.
FluspirileneThe risk or severity of adverse effects can be increased when Dezocine is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Dezocine is combined with Fluticasone Propionate.
FluvoxamineDezocine may increase the serotonergic activities of Fluvoxamine.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Dezocine.
FosphenytoinThe risk or severity of adverse effects can be increased when Dezocine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Dezocine is combined with Fospropofol.
FurosemideThe risk or severity of adverse effects can be increased when Dezocine is combined with Furosemide.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Dezocine.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Dezocine is combined with gabapentin enacarbil.
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Dezocine.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Dezocine is combined with Gamma Hydroxybutyric Acid.
GlutethimideThe risk or severity of adverse effects can be increased when Dezocine is combined with Glutethimide.
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Dezocine.
GuanfacineThe risk or severity of adverse effects can be increased when Dezocine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Dezocine.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Dezocine.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Dezocine.
HeroinThe risk or severity of adverse effects can be increased when Dezocine is combined with Heroin.
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Dezocine.
HexobarbitalThe risk or severity of adverse effects can be increased when Dezocine is combined with Hexobarbital.
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Dezocine.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Hydrochlorothiazide.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Dezocine.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Hydroflumethiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Dezocine.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Dezocine.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
HydroxyzineThe risk or severity of adverse effects can be increased when Dezocine is combined with Hydroxyzine.
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Dezocine.
IloperidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Imipramine.
IndalpineDezocine may increase the serotonergic activities of Indalpine.
IndapamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Indapamide.
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dezocine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Dezocine.
IsosorbideThe risk or severity of adverse effects can be increased when Dezocine is combined with Isosorbide.
KetamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Dezocine is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Ketobemidone.
KW-3902The risk or severity of adverse effects can be increased when Dezocine is combined with KW-3902.
LamotrigineThe risk or severity of adverse effects can be increased when Dezocine is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Dezocine is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Dezocine.
LevocabastineThe risk or severity of adverse effects can be increased when Dezocine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Dezocine is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Dezocine is combined with Levomethadyl Acetate.
LevomilnacipranDezocine may increase the serotonergic activities of Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Dezocine.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dezocine.
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Dezocine.
LithiumThe risk or severity of adverse effects can be increased when Dezocine is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Dezocine is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dezocine.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Dezocine.
Lu AA21004Dezocine may increase the serotonergic activities of Lu AA21004.
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Dezocine.
LurasidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Dezocine is combined with Magnesium Sulfate.
MannitolThe risk or severity of adverse effects can be increased when Dezocine is combined with Mannitol.
MaprotilineThe risk or severity of adverse effects can be increased when Dezocine is combined with Maprotiline.
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Dezocine.
MeclizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Dezocine.
MelperoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Melperone.
MephentermineMephentermine may increase the analgesic activities of Dezocine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Dezocine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Dezocine.
MersalylThe risk or severity of adverse effects can be increased when Dezocine is combined with Mersalyl.
MesoridazineMesoridazine may increase the hypotensive activities of Dezocine.
MesoridazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Dezocine is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Dezocine.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Dezocine is combined with Methadyl Acetate.
MethamphetamineMethamphetamine may increase the analgesic activities of Dezocine.
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Dezocine.
MethapyrileneThe risk or severity of adverse effects can be increased when Dezocine is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Methaqualone.
MethazolamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Methazolamide.
MethocarbamolThe risk or severity of adverse effects can be increased when Dezocine is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Dezocine.
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Dezocine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Dezocine.
MethsuximideThe risk or severity of adverse effects can be increased when Dezocine is combined with Methsuximide.
MethyclothiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Methyclothiazide.
Methylene blueMethylene blue may increase the hypotensive activities of Dezocine.
MethylnaltrexoneThe risk or severity of adverse effects can be increased when Methylnaltrexone is combined with Dezocine.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Dezocine.
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Dezocine.
MetolazoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Metolazone.
MetyrosineDezocine may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Dezocine.
MilnacipranDezocine may increase the serotonergic activities of Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
MirtazapineDezocine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Dezocine.
MolindoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Molindone.
MoricizineMoricizine may increase the hypotensive activities of Dezocine.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Dezocine.
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Dezocine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
NabiloneThe risk or severity of adverse effects can be increased when Dezocine is combined with Nabilone.
NalbuphineNalbuphine may decrease the analgesic activities of Dezocine.
NalbuphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Nalbuphine.
NaloxegolThe risk or severity of adverse effects can be increased when Dezocine is combined with Naloxegol.
NaltrexoneThe therapeutic efficacy of Dezocine can be decreased when used in combination with Naltrexone.
NitrazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Dezocine is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Dezocine is combined with Nortriptyline.
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Dezocine.
OlanzapineDezocine may increase the serotonergic activities of Olanzapine.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Dezocine.
OlopatadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Dezocine.
OpiumThe risk or severity of adverse effects can be increased when Dezocine is combined with Opium.
OrphenadrineDezocine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Dezocine.
OsanetantThe risk or severity of adverse effects can be increased when Dezocine is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Dezocine.
OxprenololThe risk or severity of adverse effects can be increased when Dezocine is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Dezocine.
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Dezocine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dezocine.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Dezocine.
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Dezocine.
PaliperidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Paliperidone.
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Dezocine.
ParaldehydeDezocine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Dezocine.
ParoxetineDezocine may increase the serotonergic activities of Paroxetine.
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Dezocine.
PentazocinePentazocine may decrease the analgesic activities of Dezocine.
PentazocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Dezocine.
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Dezocine.
PerampanelThe risk or severity of adverse effects can be increased when Dezocine is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Dezocine is combined with Perospirone.
PerphenazinePerphenazine may increase the hypotensive activities of Dezocine.
PerphenazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Dezocine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Dezocine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Dezocine is combined with Phenoxyethanol.
PhenterminePhentermine may increase the analgesic activities of Dezocine.
PhenytoinThe risk or severity of adverse effects can be increased when Dezocine is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Dezocine.
PipamperoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Pipamperone.
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Dezocine.
PipotiazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Pipotiazine.
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Dezocine.
PiretanideThe risk or severity of adverse effects can be increased when Dezocine is combined with Piretanide.
PizotifenThe risk or severity of adverse effects can be increased when Dezocine is combined with Pizotifen.
PolythiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Polythiazide.
PomalidomideThe risk or severity of adverse effects can be increased when Dezocine is combined with Pomalidomide.
PotassiumThe risk or severity of adverse effects can be increased when Dezocine is combined with Potassium.
Potassium CitrateThe risk or severity of adverse effects can be increased when Dezocine is combined with Potassium Citrate.
PramipexoleDezocine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dezocine.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dezocine.
PrimidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Dezocine.
ProchlorperazineProchlorperazine may increase the hypotensive activities of Dezocine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Dezocine.
PromazinePromazine may increase the hypotensive activities of Dezocine.
PromazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Promazine.
PromethazinePromethazine may increase the hypotensive activities of Dezocine.
PromethazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Promethazine.
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Dezocine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dezocine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Dezocine.
PropoxycaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Dezocine is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Dezocine is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Dezocine is combined with Quetiapine.
QuinethazoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Quinethazone.
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Dezocine.
RamelteonThe risk or severity of adverse effects can be increased when Dezocine is combined with Ramelteon.
RamosetronDezocine may increase the constipating activities of Ramosetron.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Dezocine.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Dezocine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Dezocine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Dezocine.
RomifidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Romifidine.
RopiniroleDezocine may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Dezocine.
RotigotineDezocine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Dezocine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Dezocine is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Dezocine.
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Dezocine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Dezocine.
SertindoleThe risk or severity of adverse effects can be increased when Dezocine is combined with Sertindole.
SertralineDezocine may increase the serotonergic activities of Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Dezocine is combined with Sevoflurane.
Sodium oxybateThe risk or severity of adverse effects can be increased when Dezocine is combined with Sodium oxybate.
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Dezocine.
SpironolactoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Spironolactone.
StiripentolThe risk or severity of adverse effects can be increased when Dezocine is combined with Stiripentol.
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Dezocine.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Dezocine.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Dezocine.
SuvorexantThe risk or severity of adverse effects can be increased when Dezocine is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Dezocine is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Dezocine is combined with Tasimelteon.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Dezocine.
TetrabenazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Dezocine is combined with Tetrodotoxin.
ThalidomideDezocine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Dezocine.
TheobromineThe risk or severity of adverse effects can be increased when Dezocine is combined with Theobromine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Dezocine.
ThiethylperazineThiethylperazine may increase the hypotensive activities of Dezocine.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Dezocine.
ThioridazineThioridazine may increase the hypotensive activities of Dezocine.
ThioridazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Dezocine is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tiagabine.
TicrynafenThe risk or severity of adverse effects can be increased when Dezocine is combined with Ticrynafen.
TiletamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tiletamine.
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Dezocine.
TizanidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Dezocine is combined with Tolcapone.
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Dezocine.
TolvaptanThe risk or severity of adverse effects can be increased when Dezocine is combined with Tolvaptan.
TopiramateThe risk or severity of adverse effects can be increased when Dezocine is combined with Topiramate.
TorasemideThe risk or severity of adverse effects can be increased when Dezocine is combined with Torasemide.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Dezocine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Dezocine.
TrazodoneDezocine may increase the serotonergic activities of Trazodone.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Dezocine.
TriamtereneThe risk or severity of adverse effects can be increased when Dezocine is combined with Triamterene.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Dezocine.
TrichlormethiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Trichlormethiazide.
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Dezocine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Trifluoperazine.
TriflupromazineTriflupromazine may increase the hypotensive activities of Dezocine.
TriflupromazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Triflupromazine.
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Dezocine.
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Dezocine.
TrimipramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Triprolidine.
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Dezocine.
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Dezocine.
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Dezocine.
UlaritideThe risk or severity of adverse effects can be increased when Dezocine is combined with Ularitide.
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Dezocine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Dezocine.
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Dezocine.
VigabatrinThe risk or severity of adverse effects can be increased when Dezocine is combined with Vigabatrin.
VilazodoneDezocine may increase the serotonergic activities of Vilazodone.
VortioxetineDezocine may increase the serotonergic activities of Vortioxetine.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Dezocine.
XylazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Dezocine.
ZiconotideThe risk or severity of adverse effects can be increased when Dezocine is combined with Ziconotide.
ZimelidineDezocine may increase the serotonergic activities of Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Dezocine.
ZolazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Dezocine.
ZonisamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Dezocine.
ZotepineThe risk or severity of adverse effects can be increased when Dezocine is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Dezocine is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Picker MJ: Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists. J Pharmacol Exp Ther. 1997 Dec;283(3):1009-17. [PubMed:9399970 ]
  2. Barrett AC, Cook CD, Terner JM, Craft RM, Picker MJ: Importance of sex and relative efficacy at the mu opioid receptor in the development of tolerance and cross-tolerance to the antinociceptive effects of opioids. Psychopharmacology (Berl). 2001 Nov;158(2):154-64. [PubMed:11702089 ]
  3. Cook CD, Barrett AC, Roach EL, Bowman JR, Picker MJ: Sex-related differences in the antinociceptive effects of opioids: importance of rat genotype, nociceptive stimulus intensity, and efficacy at the mu opioid receptor. Psychopharmacology (Berl). 2000 Jul;150(4):430-42. [PubMed:10958085 ]
  4. Gharagozlou P, Demirci H, David Clark J, Lameh J: Activity of opioid ligands in cells expressing cloned mu opioid receptors. BMC Pharmacol. 2003 Jan 4;3:1. Epub 2003 Jan 4. [PubMed:12513698 ]
  5. Morgan D, Cook CD, Smith MA, Picker MJ: An examination of the interactions between the antinociceptive effects of morphine and various mu-opioids: the role of intrinsic efficacy and stimulus intensity. Anesth Analg. 1999 Feb;88(2):407-13. [PubMed:9972766 ]
  6. Jacobs AM, Youngblood F: Opioid receptor affinity for agonist-antagonist analgesics. J Am Podiatr Med Assoc. 1992 Oct;82(10):520-4. [PubMed:1361946 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J: Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC Pharmacol. 2006 Jan 25;6:3. [PubMed:16433932 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23