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Identification
NamePolythiazide
Accession NumberDB01324
TypeSmall Molecule
GroupsApproved
DescriptionA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
Structure
Thumb
Synonyms
Renese
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII36780APV5N
CAS number346-18-9
WeightAverage: 439.882
Monoisotopic: 438.970880311
Chemical FormulaC11H13ClF3N3O4S3
InChI KeyInChIKey=CYLWJCABXYDINA-UHFFFAOYSA-N
InChI
InChI=1S/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,(H2,16,19,20)
IUPAC Name
6-chloro-2-methyl-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide
SMILES
CN1C(CSCC(F)(F)F)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzothiadiazines. These are organic compounds containing a benzene fused to a thiadiazine ring (a six-member ring with two nitrogen atoms and a sulfur atom).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassThiadiazines
Sub ClassBenzothiadiazines
Direct ParentBenzothiadiazines
Alternative Parents
Substituents
  • Benzothiadiazine
  • Benzenesulfonamide
  • Secondary aliphatic/aromatic amine
  • Chlorobenzene
  • Benzenoid
  • Aryl halide
  • Aryl chloride
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Azacycle
  • Dialkylthioether
  • Sulfenyl compound
  • Thioether
  • Secondary amine
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organonitrogen compound
  • Organofluoride
  • Organochloride
  • Organohalogen compound
  • Amine
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationPolythiazide is a thiazide diuretic used to decrease edema and decrease blood pressure.
PharmacodynamicsAs a thiazide diuretic, Polythiazide inhibits the sodium-chloride symporter which decreases solute reabsorption leading to a retention of water in the urine, as water normally follows solutes. More frequent urination is due to the increased loss of water that has not been retained from the body as a result of a concomitant relationship with sodium loss from the convoluted tubule. The short-term anti-hypertensive action is based on the fact that thiazides decrease preload, decreasing blood pressure
Mechanism of actionAs a diuretic, polythiazide inhibits active chloride reabsorption at the early distal tubule via the thiazide-sensitive Na-Cl cotransporter (TSC), resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like polythiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of polythiazide may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Polythiazide Action PathwayDrug actionSMP00080
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9884
Blood Brain Barrier-0.5727
Caco-2 permeable-0.6601
P-glycoprotein substrateSubstrate0.6985
P-glycoprotein inhibitor INon-inhibitor0.7714
P-glycoprotein inhibitor IINon-inhibitor0.8974
Renal organic cation transporterNon-inhibitor0.776
CYP450 2C9 substrateNon-substrate0.6019
CYP450 2D6 substrateNon-substrate0.8108
CYP450 3A4 substrateNon-substrate0.5091
CYP450 1A2 substrateNon-inhibitor0.7786
CYP450 2C9 inhibitorNon-inhibitor0.5713
CYP450 2D6 inhibitorNon-inhibitor0.8479
CYP450 2C19 inhibitorNon-inhibitor0.7738
CYP450 3A4 inhibitorInhibitor0.6198
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6625
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.8224
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.3534 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8884
hERG inhibition (predictor II)Non-inhibitor0.8734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point214 °CPhysProp
logP1.90SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.264 mg/mLALOGPS
logP2.13ALOGPS
logP1.1ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)9.31ChemAxon
pKa (Strongest Basic)-3.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area109.57 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity90.52 m3·mol-1ChemAxon
Polarizability37.56 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesC03AA05C03AB05
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
4-Androstenedione4-Androstenedione may increase the hypokalemic activities of Polythiazide.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Polythiazide.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Polythiazide.
AcebutololAcebutolol may increase the hypotensive activities of Polythiazide.
AceclofenacThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Aceclofenac.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Polythiazide.
AcetyldigitoxinThe risk or severity of adverse effects can be increased when Polythiazide is combined with Acetyldigitoxin.
Acetylsalicylic acidThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Acetylsalicylic acid.
AclidiniumThe serum concentration of Polythiazide can be increased when it is combined with Aclidinium.
AdapaleneThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Adapalene.
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Polythiazide.
AlclometasoneAlclometasone may increase the hypokalemic activities of Polythiazide.
AldosteroneAldosterone may increase the hypokalemic activities of Polythiazide.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Polythiazide.
AlfuzosinAlfuzosin may increase the hypotensive activities of Polythiazide.
AliskirenPolythiazide may increase the hypotensive activities of Aliskiren.
AllopurinolThe risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Polythiazide.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Polythiazide.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Polythiazide.
AlprenololAlprenolol may increase the hypotensive activities of Polythiazide.
AmbrisentanPolythiazide may increase the hypotensive activities of Ambrisentan.
AmcinonideAmcinonide may increase the hypokalemic activities of Polythiazide.
AmifostinePolythiazide may increase the hypotensive activities of Amifostine.
AmlodipineAmlodipine may increase the hypotensive activities of Polythiazide.
AmobarbitalAmobarbital may increase the orthostatic hypotensive activities of Polythiazide.
AmoxapineAmoxapine may increase the hyponatremic activities of Polythiazide.
Anisotropine MethylbromideThe serum concentration of Polythiazide can be increased when it is combined with Anisotropine Methylbromide.
AntipyrineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Antipyrine.
ApremilastThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Apremilast.
ArbutamineArbutamine may increase the hypokalemic activities of Polythiazide.
ArformoterolArformoterol may increase the hypokalemic activities of Polythiazide.
AtenololAtenolol may increase the hypotensive activities of Polythiazide.
Atracurium besylateThe serum concentration of Polythiazide can be increased when it is combined with Atracurium besylate.
AtropineThe serum concentration of Polythiazide can be increased when it is combined with Atropine.
AzapropazoneThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Azapropazone.
AzelastineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Azelastine.
BalsalazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Balsalazide.
BambuterolBambuterol may increase the hypokalemic activities of Polythiazide.
BarbitalBarbital may increase the orthostatic hypotensive activities of Polythiazide.
Beclomethasone dipropionateBeclomethasone dipropionate may increase the hypokalemic activities of Polythiazide.
BenactyzineThe serum concentration of Polythiazide can be increased when it is combined with Benactyzine.
BenazeprilBenazepril may increase the hypotensive activities of Polythiazide.
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Polythiazide.
BenmoxinBenmoxin may increase the hypotensive activities of Polythiazide.
BenoxaprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Benoxaprofen.
BenzatropineThe serum concentration of Polythiazide can be increased when it is combined with Benzatropine.
BepridilBepridil may increase the hypotensive activities of Polythiazide.
BetamethasoneBetamethasone may increase the hypokalemic activities of Polythiazide.
BetaxololBetaxolol may increase the hypotensive activities of Polythiazide.
BethanidineBethanidine may increase the hypotensive activities of Polythiazide.
BezitramideThe risk or severity of adverse effects can be increased when Bezitramide is combined with Polythiazide.
BimatoprostBimatoprost may increase the hypotensive activities of Polythiazide.
BiperidenThe serum concentration of Polythiazide can be increased when it is combined with Biperiden.
BisoprololBisoprolol may increase the hypotensive activities of Polythiazide.
BosentanBosentan may increase the hypotensive activities of Polythiazide.
BretyliumBretylium may increase the hypotensive activities of Polythiazide.
BrimonidinePolythiazide may increase the hypotensive activities of Brimonidine.
BrimonidineBrimonidine may increase the antihypertensive activities of Polythiazide.
BromfenacThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Bromfenac.
BudesonideBudesonide may increase the hypokalemic activities of Polythiazide.
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Polythiazide.
BupranololPolythiazide may increase the hypotensive activities of Bupranolol.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Polythiazide.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Polythiazide.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Polythiazide.
CandesartanCandesartan may increase the hypotensive activities of Polythiazide.
CandoxatrilCandoxatril may increase the hypotensive activities of Polythiazide.
CaptoprilCaptopril may increase the hypotensive activities of Polythiazide.
CarbamazepineThe risk or severity of adverse effects can be increased when Polythiazide is combined with Carbamazepine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Polythiazide.
CaroxazoneCaroxazone may increase the hypotensive activities of Polythiazide.
CarprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Carprofen.
CarteololCarteolol may increase the hypotensive activities of Polythiazide.
CarvedilolCarvedilol may increase the hypotensive activities of Polythiazide.
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Polythiazide.
CelecoxibThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Celecoxib.
CeliprololPolythiazide may increase the hypotensive activities of Celiprolol.
ChloroquineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Chloroquine.
ChlorothiazideChlorothiazide may increase the hypotensive activities of Polythiazide.
ChlorphenoxamineThe serum concentration of Polythiazide can be increased when it is combined with Chlorphenoxamine.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Polythiazide.
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Polythiazide.
CholestyramineCholestyramine can cause a decrease in the absorption of Polythiazide resulting in a reduced serum concentration and potentially a decrease in efficacy.
CiclesonideCiclesonide may increase the hypokalemic activities of Polythiazide.
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Polythiazide.
CilazaprilPolythiazide may increase the hypotensive activities of Cilazapril.
CitalopramCitalopram may increase the hyponatremic activities of Polythiazide.
ClenbuterolClenbuterol may increase the hypokalemic activities of Polythiazide.
Clobetasol propionateClobetasol propionate may increase the hypokalemic activities of Polythiazide.
ClocortoloneClocortolone may increase the hypokalemic activities of Polythiazide.
ClomipramineClomipramine may increase the hyponatremic activities of Polythiazide.
ClonidineClonidine may increase the hypotensive activities of Polythiazide.
ClonixinThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Clonixin.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Polythiazide.
ColesevelamColesevelam can cause a decrease in the absorption of Polythiazide resulting in a reduced serum concentration and potentially a decrease in efficacy.
ColestipolColestipol can cause a decrease in the absorption of Polythiazide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cortisone acetateCortisone acetate may increase the hypokalemic activities of Polythiazide.
CryptenamineCryptenamine may increase the hypotensive activities of Polythiazide.
CyclopentolateThe serum concentration of Polythiazide can be increased when it is combined with Cyclopentolate.
CyclophosphamideThe risk or severity of adverse effects can be increased when Polythiazide is combined with Cyclophosphamide.
CyclothiazideCyclothiazide may increase the hypotensive activities of Polythiazide.
D-LimoneneThe therapeutic efficacy of Polythiazide can be decreased when used in combination with D-Limonene.
DapoxetineDapoxetine may increase the hyponatremic activities of Polythiazide.
DarifenacinThe serum concentration of Polythiazide can be increased when it is combined with Darifenacin.
DebrisoquinPolythiazide may increase the hypotensive activities of Debrisoquin.
DehydroepiandrosteroneDehydroepiandrosterone may increase the hypokalemic activities of Polythiazide.
dehydroepiandrosterone sulfatedehydroepiandrosterone sulfate may increase the hypokalemic activities of Polythiazide.
DeserpidinePolythiazide may increase the hypotensive activities of Deserpidine.
DeslanosideThe risk or severity of adverse effects can be increased when Polythiazide is combined with Deslanoside.
DesloratadineThe serum concentration of Polythiazide can be increased when it is combined with Desloratadine.
DesoximetasoneDesoximetasone may increase the hypokalemic activities of Polythiazide.
Desoxycorticosterone acetateDesoxycorticosterone acetate may increase the hypokalemic activities of Polythiazide.
DexamethasoneDexamethasone may increase the hypokalemic activities of Polythiazide.
Dexamethasone isonicotinateDexamethasone isonicotinate may increase the hypokalemic activities of Polythiazide.
DexetimideThe serum concentration of Polythiazide can be increased when it is combined with Dexetimide.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Polythiazide.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Polythiazide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Polythiazide.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Polythiazide.
DiazoxideDiazoxide may increase the hypotensive activities of Polythiazide.
DiazoxideThe risk or severity of adverse effects can be increased when Polythiazide is combined with Diazoxide.
DiclofenacThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Diclofenac.
DicyclomineThe serum concentration of Polythiazide can be increased when it is combined with Dicyclomine.
DiflorasoneDiflorasone may increase the hypokalemic activities of Polythiazide.
DiflunisalThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Diflunisal.
DifluocortoloneDifluocortolone may increase the hypokalemic activities of Polythiazide.
DifluprednateDifluprednate may increase the hypokalemic activities of Polythiazide.
DigitoxinThe risk or severity of adverse effects can be increased when Polythiazide is combined with Digitoxin.
DigoxinThe risk or severity of adverse effects can be increased when Polythiazide is combined with Digoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Polythiazide.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Polythiazide.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Polythiazide.
DiltiazemDiltiazem may increase the hypotensive activities of Polythiazide.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Polythiazide.
DipivefrinDipivefrin may increase the hypokalemic activities of Polythiazide.
DobutamineDobutamine may increase the hypokalemic activities of Polythiazide.
DofetilidePolythiazide may increase the QTc-prolonging activities of Dofetilide.
DorzolamideDorzolamide may increase the hypotensive activities of Polythiazide.
DoxazosinDoxazosin may increase the hypotensive activities of Polythiazide.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Polythiazide.
DroxicamThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Droxicam.
DroxidopaDroxidopa may increase the hypokalemic activities of Polythiazide.
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Polythiazide.
EfonidipinePolythiazide may increase the hypotensive activities of Efonidipine.
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Polythiazide.
EnalaprilEnalapril may increase the hypotensive activities of Polythiazide.
EnalaprilatPolythiazide may increase the hypotensive activities of Enalaprilat.
EphedraEphedra may increase the hypokalemic activities of Polythiazide.
EpinephrineEpinephrine may increase the hypokalemic activities of Polythiazide.
EpirizoleThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Epirizole.
EpoprostenolEpoprostenol may increase the hypotensive activities of Polythiazide.
EprosartanEprosartan may increase the hypotensive activities of Polythiazide.
EquileninEquilenin may increase the hypokalemic activities of Polythiazide.
EquilinEquilin may increase the hypokalemic activities of Polythiazide.
EscitalopramEscitalopram may increase the hyponatremic activities of Polythiazide.
EstroneEstrone may increase the hypokalemic activities of Polythiazide.
EtanerceptThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Etanercept.
EthanolEthanol may increase the orthostatic hypotensive activities of Polythiazide.
EthopropazineThe serum concentration of Polythiazide can be increased when it is combined with Ethopropazine.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Polythiazide.
EtodolacThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Etodolac.
EtofenamateThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Etofenamate.
EtoperidoneEtoperidone may increase the hyponatremic activities of Polythiazide.
EtoricoxibThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Etoricoxib.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Polythiazide.
Evening primrose oilThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Evening primrose oil.
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Polythiazide.
exisulindThe therapeutic efficacy of Polythiazide can be decreased when used in combination with exisulind.
FelodipineFelodipine may increase the hypotensive activities of Polythiazide.
FenbufenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Fenbufen.
FenfluramineFenfluramine may increase the hyponatremic activities of Polythiazide.
FenoldopamFenoldopam may increase the hypotensive activities of Polythiazide.
FenoprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Fenoprofen.
FenoterolFenoterol may increase the hypokalemic activities of Polythiazide.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Polythiazide.
FesoterodineThe serum concentration of Polythiazide can be increased when it is combined with Fesoterodine.
FloctafenineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Floctafenine.
FludrocortisoneFludrocortisone may increase the hypokalemic activities of Polythiazide.
FlumethasoneFlumethasone may increase the hypokalemic activities of Polythiazide.
FlunisolideFlunisolide may increase the hypokalemic activities of Polythiazide.
FlunixinThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Flunixin.
Fluocinolone AcetonideFluocinolone Acetonide may increase the hypokalemic activities of Polythiazide.
FluocinonideFluocinonide may increase the hypokalemic activities of Polythiazide.
FluocortoloneFluocortolone may increase the hypokalemic activities of Polythiazide.
FluorometholoneFluorometholone may increase the hypokalemic activities of Polythiazide.
FluoxetineFluoxetine may increase the hyponatremic activities of Polythiazide.
FluprednideneFluprednidene may increase the hypokalemic activities of Polythiazide.
FluprednisoloneFluprednisolone may increase the hypokalemic activities of Polythiazide.
FlurandrenolideFlurandrenolide may increase the hypokalemic activities of Polythiazide.
FlurbiprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Flurbiprofen.
Fluticasone furoateFluticasone furoate may increase the hypokalemic activities of Polythiazide.
Fluticasone PropionateFluticasone Propionate may increase the hypokalemic activities of Polythiazide.
FluvoxamineFluvoxamine may increase the hyponatremic activities of Polythiazide.
FormoterolFormoterol may increase the hypokalemic activities of Polythiazide.
FosinoprilFosinopril may increase the hypotensive activities of Polythiazide.
FurazolidoneFurazolidone may increase the hypotensive activities of Polythiazide.
Gallamine TriethiodideThe serum concentration of Polythiazide can be increased when it is combined with Gallamine Triethiodide.
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Polythiazide.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Polythiazide.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Polythiazide.
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Polythiazide.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Polythiazide.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Polythiazide.
GlycopyrroniumThe serum concentration of Polythiazide can be increased when it is combined with Glycopyrronium.
GuanabenzGuanabenz may increase the hypotensive activities of Polythiazide.
GuanadrelGuanadrel may increase the hypotensive activities of Polythiazide.
GuanethidineGuanethidine may increase the hypotensive activities of Polythiazide.
GuanfacineGuanfacine may increase the hypotensive activities of Polythiazide.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Polythiazide.
HexamethoniumPolythiazide may increase the hypotensive activities of Hexamethonium.
HexobarbitalHexobarbital may increase the orthostatic hypotensive activities of Polythiazide.
HMPL-004The therapeutic efficacy of Polythiazide can be decreased when used in combination with HMPL-004.
HomatropineThe serum concentration of Polythiazide can be increased when it is combined with Homatropine.
HydracarbazineHydracarbazine may increase the hypotensive activities of Polythiazide.
HydralazineHydralazine may increase the hypotensive activities of Polythiazide.
HydrochlorothiazideHydrochlorothiazide may increase the hypotensive activities of Polythiazide.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Polythiazide.
HydrocortisoneHydrocortisone may increase the hypokalemic activities of Polythiazide.
HydroflumethiazideHydroflumethiazide may increase the hypotensive activities of Polythiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Polythiazide.
HyoscyamineThe serum concentration of Polythiazide can be increased when it is combined with Hyoscyamine.
IbuprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Ibuprofen.
IbuproxamThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Ibuproxam.
IcatibantThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Icatibant.
IloprostIloprost may increase the hypotensive activities of Polythiazide.
IndacaterolIndacaterol may increase the hypokalemic activities of Polythiazide.
IndalpineIndalpine may increase the hyponatremic activities of Polythiazide.
IndapamideIndapamide may increase the hypotensive activities of Polythiazide.
IndenololPolythiazide may increase the hypotensive activities of Indenolol.
IndomethacinThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Indomethacin.
IndoprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Indoprofen.
IndoraminPolythiazide may increase the hypotensive activities of Indoramin.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Polythiazide.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Polythiazide.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Polythiazide.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Polythiazide.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Polythiazide.
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Polythiazide.
Ipratropium bromideThe serum concentration of Polythiazide can be increased when it is combined with Ipratropium bromide.
IproclozideIproclozide may increase the hypotensive activities of Polythiazide.
IproniazidIproniazid may increase the hypotensive activities of Polythiazide.
IrbesartanIrbesartan may increase the hypotensive activities of Polythiazide.
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Polythiazide.
IsoetarineIsoetarine may increase the hypokalemic activities of Polythiazide.
IsoprenalineIsoprenaline may increase the hypokalemic activities of Polythiazide.
IsoxicamThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Isoxicam.
IsradipineIsradipine may increase the hypotensive activities of Polythiazide.
IvabradinePolythiazide may increase the arrhythmogenic activities of Ivabradine.
KebuzoneThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Kebuzone.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Polythiazide.
KetoprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Ketoprofen.
KetorolacThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Ketorolac.
LabetalolLabetalol may increase the hypotensive activities of Polythiazide.
LacidipinePolythiazide may increase the hypotensive activities of Lacidipine.
LatanoprostLatanoprost may increase the hypotensive activities of Polythiazide.
LeflunomideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Leflunomide.
LercanidipineLercanidipine may increase the hypotensive activities of Polythiazide.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Polythiazide.
LevomilnacipranLevomilnacipran may increase the hyponatremic activities of Polythiazide.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Polythiazide.
LicoriceLicorice may increase the hypokalemic activities of Polythiazide.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Polythiazide.
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Polythiazide.
LisinoprilLisinopril may increase the hypotensive activities of Polythiazide.
LithiumPolythiazide may decrease the excretion rate of Lithium which could result in a lower serum level and potentially a reduction in efficacy.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Polythiazide.
LofexidinePolythiazide may increase the hypotensive activities of Lofexidine.
LornoxicamThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Lornoxicam.
LosartanLosartan may increase the hypotensive activities of Polythiazide.
LoxoprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Loxoprofen.
Lu AA21004Lu AA21004 may increase the hyponatremic activities of Polythiazide.
LumiracoxibThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Lumiracoxib.
MacitentanPolythiazide may increase the hypotensive activities of Macitentan.
Magnesium salicylateThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Magnesium salicylate.
ManidipinePolythiazide may increase the hypotensive activities of Manidipine.
MasoprocolThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Masoprocol.
MebanazineMebanazine may increase the hypotensive activities of Polythiazide.
MecamylamineThe risk or severity of adverse effects can be increased when Polythiazide is combined with Mecamylamine.
MecamylamineMecamylamine may increase the hypotensive activities of Polythiazide.
Meclofenamic acidThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Meclofenamic acid.
MedrysoneMedrysone may increase the hypokalemic activities of Polythiazide.
Mefenamic acidThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Mefenamic acid.
MelengestrolMelengestrol may increase the hypokalemic activities of Polythiazide.
MeloxicamThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Meloxicam.
MesalazineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Mesalazine.
MetamizoleThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Metamizole.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Polythiazide.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Polythiazide.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Polythiazide.
MethanthelineThe serum concentration of Polythiazide can be increased when it is combined with Methantheline.
MethohexitalMethohexital may increase the orthostatic hypotensive activities of Polythiazide.
MethyldopaMethyldopa may increase the hypotensive activities of Polythiazide.
Methylene blueMethylene blue may increase the hypotensive activities of Polythiazide.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Polythiazide.
MethylphenobarbitalMethylphenobarbital may increase the orthostatic hypotensive activities of Polythiazide.
MethylprednisoloneMethylprednisolone may increase the hypokalemic activities of Polythiazide.
MetipranololMetipranolol may increase the hypotensive activities of Polythiazide.
MetixeneThe serum concentration of Polythiazide can be increased when it is combined with Metixene.
MetolazoneMetolazone may increase the hypotensive activities of Polythiazide.
MetoprololMetoprolol may increase the hypotensive activities of Polythiazide.
MibefradilPolythiazide may increase the hypotensive activities of Mibefradil.
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Polythiazide.
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Polythiazide.
MilnacipranMilnacipran may increase the hyponatremic activities of Polythiazide.
MinaprineMinaprine may increase the hypotensive activities of Polythiazide.
MinoxidilMinoxidil may increase the hypotensive activities of Polythiazide.
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Polythiazide.
MoclobemideMoclobemide may increase the hypotensive activities of Polythiazide.
MoexiprilMoexipril may increase the hypotensive activities of Polythiazide.
MolsidomineMolsidomine may increase the hypotensive activities of Polythiazide.
MometasoneMometasone may increase the hypokalemic activities of Polythiazide.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Polythiazide.
MoxonidinePolythiazide may increase the hypotensive activities of Moxonidine.
Mycophenolate mofetilThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Mycophenolate mofetil.
Mycophenolic acidThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Mycophenolic acid.
N-butylscopolammonium bromideThe serum concentration of Polythiazide can be increased when it is combined with N-butylscopolammonium bromide.
NabumetoneThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Nabumetone.
NadololNadolol may increase the hypotensive activities of Polythiazide.
NaftifineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Naftifine.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Polythiazide.
NaproxenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Naproxen.
NateglinideThe therapeutic efficacy of Nateglinide can be decreased when used in combination with Polythiazide.
NCX 4016The therapeutic efficacy of Polythiazide can be decreased when used in combination with NCX 4016.
NebivololPolythiazide may increase the hypotensive activities of Nebivolol.
NepafenacThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Nepafenac.
NialamideNialamide may increase the hypotensive activities of Polythiazide.
NicardipineNicardipine may increase the hypotensive activities of Polythiazide.
NicorandilPolythiazide may increase the hypotensive activities of Nicorandil.
Niflumic AcidThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Niflumic Acid.
NiguldipinePolythiazide may increase the hypotensive activities of Niguldipine.
NilvadipinePolythiazide may increase the hypotensive activities of Nilvadipine.
NimesulideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Nimesulide.
NimodipineNimodipine may increase the hypotensive activities of Polythiazide.
NisoldipineNisoldipine may increase the hypotensive activities of Polythiazide.
NitrendipineNitrendipine may increase the hypotensive activities of Polythiazide.
NitroprussideNitroprusside may increase the hypotensive activities of Polythiazide.
NorepinephrineNorepinephrine may increase the hypokalemic activities of Polythiazide.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Polythiazide.
NVA237The serum concentration of Polythiazide can be increased when it is combined with NVA237.
ObinutuzumabPolythiazide may increase the hypotensive activities of Obinutuzumab.
OctamoxinOctamoxin may increase the hypotensive activities of Polythiazide.
OlanzapineOlanzapine may increase the hyponatremic activities of Polythiazide.
OlmesartanOlmesartan may increase the hypotensive activities of Polythiazide.
OlodaterolOlodaterol may increase the hypokalemic activities of Polythiazide.
OlopatadineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Olopatadine.
OlsalazineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Olsalazine.
OmapatrilatOmapatrilat may increase the hypotensive activities of Polythiazide.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Polythiazide.
OrciprenalineOrciprenaline may increase the hypokalemic activities of Polythiazide.
OrgoteinThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Orgotein.
OrphenadrineThe serum concentration of Polythiazide can be increased when it is combined with Orphenadrine.
OuabainThe risk or severity of adverse effects can be increased when Polythiazide is combined with Ouabain.
OxaprozinThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Oxaprozin.
OxcarbazepineThe risk or severity of adverse effects can be increased when Polythiazide is combined with Oxcarbazepine.
OxprenololPolythiazide may increase the hypotensive activities of Oxprenolol.
OxybutyninThe serum concentration of Polythiazide can be increased when it is combined with Oxybutynin.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Polythiazide.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Polythiazide.
OxyphenbutazoneThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Oxyphenbutazone.
OxyphenoniumThe serum concentration of Polythiazide can be increased when it is combined with Oxyphenonium.
PancuroniumThe serum concentration of Polythiazide can be increased when it is combined with Pancuronium.
ParamethasoneParamethasone may increase the hypokalemic activities of Polythiazide.
ParecoxibThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Parecoxib.
PargylinePolythiazide may increase the hypotensive activities of Pargyline.
ParoxetineParoxetine may increase the hyponatremic activities of Polythiazide.
PenbutololPolythiazide may increase the hypotensive activities of Penbutolol.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Polythiazide.
PentobarbitalPentobarbital may increase the orthostatic hypotensive activities of Polythiazide.
PentoliniumPentolinium may increase the hypotensive activities of Polythiazide.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Polythiazide.
PerindoprilPerindopril may increase the hypotensive activities of Polythiazide.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Polythiazide.
PhenelzinePhenelzine may increase the hypotensive activities of Polythiazide.
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Polythiazide.
PheniprazinePheniprazine may increase the hypotensive activities of Polythiazide.
PhenobarbitalPhenobarbital may increase the orthostatic hypotensive activities of Polythiazide.
PhenoxybenzaminePhenoxybenzamine may increase the hypotensive activities of Polythiazide.
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Polythiazide.
PhentolaminePhentolamine may increase the hypotensive activities of Polythiazide.
PhenylbutazoneThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Phenylbutazone.
PhenylpropanolaminePhenylpropanolamine may increase the hypokalemic activities of Polythiazide.
PimecrolimusThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Pimecrolimus.
PinacidilPolythiazide may increase the hypotensive activities of Pinacidil.
PindololPindolol may increase the hypotensive activities of Polythiazide.
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Polythiazide.
PipecuroniumThe serum concentration of Polythiazide can be increased when it is combined with Pipecuronium.
PirbuterolPirbuterol may increase the hypokalemic activities of Polythiazide.
PirenzepineThe serum concentration of Polythiazide can be increased when it is combined with Pirenzepine.
PirfenidoneThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Pirfenidone.
PirlindolePirlindole may increase the hypotensive activities of Polythiazide.
PiroxicamThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Piroxicam.
PivhydrazinePivhydrazine may increase the hypotensive activities of Polythiazide.
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Polythiazide.
PrazosinPrazosin may increase the hypotensive activities of Polythiazide.
PrednicarbatePrednicarbate may increase the hypokalemic activities of Polythiazide.
PrednisolonePrednisolone may increase the hypokalemic activities of Polythiazide.
PrednisonePrednisone may increase the hypokalemic activities of Polythiazide.
PregnenolonePregnenolone may increase the hypokalemic activities of Polythiazide.
PrimidonePrimidone may increase the orthostatic hypotensive activities of Polythiazide.
ProcaterolProcaterol may increase the hypokalemic activities of Polythiazide.
ProcyclidineThe serum concentration of Polythiazide can be increased when it is combined with Procyclidine.
PropacetamolThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Propacetamol.
PropanthelineThe serum concentration of Polythiazide can be increased when it is combined with Propantheline.
PropranololPropranolol may increase the hypotensive activities of Polythiazide.
PTC299The therapeutic efficacy of Polythiazide can be decreased when used in combination with PTC299.
QuinaprilQuinapril may increase the hypotensive activities of Polythiazide.
QuinidineThe serum concentration of Polythiazide can be increased when it is combined with Quinidine.
QuinineQuinine may increase the hypotensive activities of Polythiazide.
RamiprilRamipril may increase the hypotensive activities of Polythiazide.
RasagilineRasagiline may increase the hypotensive activities of Polythiazide.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Polythiazide.
RemikirenRemikiren may increase the hypotensive activities of Polythiazide.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Polythiazide.
RescinnaminePolythiazide may increase the hypotensive activities of Rescinnamine.
ReserpineReserpine may increase the hypotensive activities of Polythiazide.
ResveratrolThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Resveratrol.
RimexoloneRimexolone may increase the hypokalemic activities of Polythiazide.
RiociguatPolythiazide may increase the hypotensive activities of Riociguat.
RitodrineRitodrine may increase the hypokalemic activities of Polythiazide.
RituximabPolythiazide may increase the hypotensive activities of Rituximab.
RofecoxibThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Rofecoxib.
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Polythiazide.
SafrazineSafrazine may increase the hypotensive activities of Polythiazide.
SalbutamolSalbutamol may increase the hypokalemic activities of Polythiazide.
SalicylamideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Salicylamide.
Salicylic acidThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Salicylic acid.
SalmeterolSalmeterol may increase the hypokalemic activities of Polythiazide.
SalsalateThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Salsalate.
SaprisartanPolythiazide may increase the hypotensive activities of Saprisartan.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Polythiazide.
ScopolamineThe serum concentration of Polythiazide can be increased when it is combined with Scopolamine.
Scopolamine butylbromideThe serum concentration of Polythiazide can be increased when it is combined with Scopolamine butylbromide.
SecobarbitalSecobarbital may increase the orthostatic hypotensive activities of Polythiazide.
SelegilineSelegiline may increase the hypotensive activities of Polythiazide.
SelexipagPolythiazide may increase the hypotensive activities of Selexipag.
SeratrodastThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Seratrodast.
SertralineSertraline may increase the hyponatremic activities of Polythiazide.
SildenafilSildenafil may increase the antihypertensive activities of Polythiazide.
SitagliptinThe therapeutic efficacy of Sitagliptin can be decreased when used in combination with Polythiazide.
SitaxentanPolythiazide may increase the hypotensive activities of Sitaxentan.
SolifenacinThe serum concentration of Polythiazide can be increased when it is combined with Solifenacin.
SpiraprilPolythiazide may increase the hypotensive activities of Spirapril.
SRT501The therapeutic efficacy of Polythiazide can be decreased when used in combination with SRT501.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Polythiazide.
SulfasalazineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Sulfasalazine.
SulindacThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Sulindac.
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Polythiazide.
SulpirideThe risk or severity of adverse effects can be increased when Polythiazide is combined with Sulpiride.
SuprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Suprofen.
TadalafilTadalafil may increase the antihypertensive activities of Polythiazide.
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Polythiazide.
TelmisartanTelmisartan may increase the hypotensive activities of Polythiazide.
TemocaprilPolythiazide may increase the hypotensive activities of Temocapril.
TenoxicamThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Tenoxicam.
TepoxalinThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Tepoxalin.
TerbutalineTerbutaline may increase the hypokalemic activities of Polythiazide.
TeriflunomideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Teriflunomide.
TerlipressinPolythiazide may increase the hypotensive activities of Terlipressin.
ThiamylalThiamylal may increase the orthostatic hypotensive activities of Polythiazide.
ThiopentalThiopental may increase the orthostatic hypotensive activities of Polythiazide.
Tiaprofenic acidThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Tiaprofenic acid.
TibolonePolythiazide may increase the hypotensive activities of Tibolone.
TicrynafenPolythiazide may increase the hypotensive activities of Ticrynafen.
TimololTimolol may increase the hypotensive activities of Polythiazide.
TiotropiumThe serum concentration of Polythiazide can be increased when it is combined with Tiotropium.
TixocortolTixocortol may increase the hypokalemic activities of Polythiazide.
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Polythiazide.
TolazolineTolazoline may increase the hypotensive activities of Polythiazide.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Polythiazide.
Tolfenamic AcidThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Tolfenamic Acid.
TolmetinThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Tolmetin.
ToloxatoneToloxatone may increase the hypotensive activities of Polythiazide.
TolterodineThe serum concentration of Polythiazide can be increased when it is combined with Tolterodine.
TopiramatePolythiazide may increase the hypokalemic activities of Topiramate.
TorasemideTorasemide may increase the hypotensive activities of Polythiazide.
ToremifenePolythiazide may increase the hypercalcemic activities of Toremifene.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Polythiazide.
TrandolaprilTrandolapril may increase the hypotensive activities of Polythiazide.
TranilastThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Tranilast.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Polythiazide.
TranylcypromineTranylcypromine may increase the hypotensive activities of Polythiazide.
TravoprostTravoprost may increase the hypotensive activities of Polythiazide.
TrazodoneTrazodone may increase the hyponatremic activities of Polythiazide.
TreprostinilTreprostinil may increase the hypotensive activities of Polythiazide.
TriamcinoloneTriamcinolone may increase the hypokalemic activities of Polythiazide.
TrichlormethiazideTrichlormethiazide may increase the hypotensive activities of Polythiazide.
TrihexyphenidylThe serum concentration of Polythiazide can be increased when it is combined with Trihexyphenidyl.
TrimazosinPolythiazide may increase the hypotensive activities of Trimazosin.
TrimethaphanTrimethaphan may increase the hypotensive activities of Polythiazide.
Trisalicylate-cholineThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Trisalicylate-choline.
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Polythiazide.
TropicamideThe serum concentration of Polythiazide can be increased when it is combined with Tropicamide.
TrospiumThe serum concentration of Polythiazide can be increased when it is combined with Trospium.
TubocurarineThe serum concentration of Polythiazide can be increased when it is combined with Tubocurarine.
UdenafilUdenafil may increase the antihypertensive activities of Polythiazide.
UmeclidiniumThe serum concentration of Polythiazide can be increased when it is combined with Umeclidinium.
UnoprostonePolythiazide may increase the hypotensive activities of Unoprostone.
ValdecoxibThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Valdecoxib.
ValsartanValsartan may increase the hypotensive activities of Polythiazide.
VardenafilVardenafil may increase the antihypertensive activities of Polythiazide.
VecuroniumThe serum concentration of Polythiazide can be increased when it is combined with Vecuronium.
VilanterolVilanterol may increase the hypokalemic activities of Polythiazide.
VilazodoneVilazodone may increase the hyponatremic activities of Polythiazide.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Polythiazide.
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Polythiazide.
VortioxetineVortioxetine may increase the hyponatremic activities of Polythiazide.
XylometazolinePolythiazide may increase the hypotensive activities of Xylometazoline.
YohimbineYohimbine may decrease the antihypertensive activities of Polythiazide.
ZaltoprofenThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Zaltoprofen.
ZileutonThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Zileuton.
ZimelidineZimelidine may increase the hyponatremic activities of Polythiazide.
ZomepiracThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Zomepirac.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption.
Gene Name:
SLC12A3
Uniprot ID:
P55017
Molecular Weight:
113138.04 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Monroy A, Plata C, Hebert SC, Gamba G: Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9. [PubMed:10894798 ]
  3. Frindt G, McNair T, Dahlmann A, Jacobs-Palmer E, Palmer LG: Epithelial Na channels and short-term renal response to salt deprivation. Am J Physiol Renal Physiol. 2002 Oct;283(4):F717-26. [PubMed:12217863 ]
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Drug created on June 30, 2007 11:21 / Updated on August 17, 2016 12:23