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Identification
NameGlutethimide
Accession NumberDB01437
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA hypnotic and sedative. Its use has been largely superseded by other drugs. [PubChem]
Structure
Thumb
Synonyms
2-Ethyl-2-phenylglutarimide
Doriden
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
DoridenU.S.V .
ElrodormNot Available
GlimidPolfa Pabianice
GlutethimidBalkanpharma
NoxyronNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIC8I4BVN78E
CAS number77-21-4
WeightAverage: 217.2637
Monoisotopic: 217.110278729
Chemical FormulaC13H15NO2
InChI KeyInChIKey=JMBQKKAJIKAWKF-UHFFFAOYSA-N
InChI
InChI=1S/C13H15NO2/c1-2-13(10-6-4-3-5-7-10)9-8-11(15)14-12(13)16/h3-7H,2,8-9H2,1H3,(H,14,15,16)
IUPAC Name
3-ethyl-3-phenylpiperidine-2,6-dione
SMILES
CCC1(CCC(=O)NC1=O)C1=CC=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPiperidines
Sub ClassPhenylpiperidines
Direct ParentPhenylpiperidines
Alternative Parents
Substituents
  • Phenylpiperidine
  • Piperidinedione
  • Piperidinone
  • Dicarboximide
  • Delta-lactam
  • Benzenoid
  • Monocyclic benzene moiety
  • Carboxylic acid imide, n-unsubstituted
  • Carboxylic acid imide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of insomnia.
PharmacodynamicsGlutethimide is a hypnotic sedative that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similarly severe withdrawal symptoms.
Mechanism of actionGlutethimide seems to be a GABA agonist which helps induced sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) to morphine. The general sedative effect also adds to the power of the combination.
Related Articles
AbsorptionVariable
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic. Glutethimide is almost completely metabolized.

Route of eliminationglutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces.
Half life10-12 hours
ClearanceNot Available
ToxicityIn adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9973
Blood Brain Barrier+0.996
Caco-2 permeable+0.5931
P-glycoprotein substrateSubstrate0.6677
P-glycoprotein inhibitor INon-inhibitor0.5334
P-glycoprotein inhibitor IINon-inhibitor0.9611
Renal organic cation transporterNon-inhibitor0.7747
CYP450 2C9 substrateNon-substrate0.7785
CYP450 2D6 substrateNon-substrate0.894
CYP450 3A4 substrateSubstrate0.5173
CYP450 1A2 substrateNon-inhibitor0.8856
CYP450 2C9 inhibitorNon-inhibitor0.9101
CYP450 2D6 inhibitorNon-inhibitor0.8664
CYP450 2C19 inhibitorNon-inhibitor0.8671
CYP450 3A4 inhibitorNon-inhibitor0.863
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8527
Ames testNon AMES toxic0.8254
CarcinogenicityNon-carcinogens0.8911
BiodegradationNot ready biodegradable0.9927
Rat acute toxicity2.5276 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9778
hERG inhibition (predictor II)Non-inhibitor0.7311
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point78-81Hoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc.
water solubility999 mg/L (at 30 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.90HANSCH,C ET AL. (1995)
logS-2.34ADME Research, USCD
pKa9.2SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.327 mg/mLALOGPS
logP1.89ALOGPS
logP2.13ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)11.69ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.17 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity60.65 m3·mol-1ChemAxon
Polarizability23.15 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (9.43 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Hoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc.

General ReferencesNot Available
External Links
ATC CodesN05CE01
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when Glutethimide is combined with 7-Nitroindazole.
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Glutethimide.
AcepromazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Glutethimide is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Glutethimide.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Glutethimide.
AmisulprideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amitriptyline.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Glutethimide.
AmoxapineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amperozide.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Glutethimide.
ArticaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Asenapine.
AzaperoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Azaperone.
AzelastineGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Glutethimide.
BaclofenThe risk or severity of adverse effects can be increased when Glutethimide is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Barbital.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Glutethimide.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Glutethimide is combined with Benzyl alcohol.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
BrimonidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Glutethimide.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Glutethimide.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Glutethimide.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Glutethimide.
ButacaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Glutethimide.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Glutethimide.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Glutethimide.
CarbinoxamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Glutethimide.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Glutethimide.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Glutethimide.
ChlorphenamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Glutethimide.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Glutethimide.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Glutethimide.
CitalopramThe risk or severity of adverse effects can be increased when Glutethimide is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Glutethimide is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Glutethimide.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Glutethimide.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Glutethimide.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Glutethimide.
CyclizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Glutethimide.
CyproheptadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Glutethimide.
DapoxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dapoxetine.
deramciclaneThe risk or severity of adverse effects can be increased when Glutethimide is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Glutethimide.
DesipramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Glutethimide.
DextromoramideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Glutethimide.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Glutethimide.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Glutethimide.
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Glutethimide.
DifenoxinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Glutethimide.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Glutethimide.
DoramectinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
DoxylamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Glutethimide is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Glutethimide.
DrotebanolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Glutethimide.
EcgonineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Glutethimide is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Glutethimide is combined with Efavirenz.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Glutethimide.
EntacaponeThe risk or severity of adverse effects can be increased when Glutethimide is combined with Entacapone.
EscitalopramThe risk or severity of adverse effects can be increased when Glutethimide is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Glutethimide.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Glutethimide.
EthanolGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Glutethimide.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Glutethimide.
EthosuximideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethotoin.
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Glutethimide.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Glutethimide.
EtoperidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etorphine.
EzogabineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Glutethimide.
FexofenadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flunitrazepam.
FluoxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Glutethimide.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Glutethimide.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Glutethimide.
FluspirileneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fospropofol.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Glutethimide.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Glutethimide is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Glutethimide is combined with Gamma Hydroxybutyric Acid.
GuanfacineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Glutethimide.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Glutethimide.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Glutethimide.
HeroinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Heroin.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Glutethimide.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Glutethimide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Glutethimide.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
HydroxyzineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Indalpine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Glutethimide.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Glutethimide.
KetazolamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ketobemidone.
LamotrigineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Glutethimide.
LevocabastineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Glutethimide.
LevomilnacipranThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Glutethimide.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Glutethimide.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Glutethimide.
LofentanilThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Glutethimide.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Glutethimide.
Lu AA21004The risk or severity of adverse effects can be increased when Glutethimide is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Glutethimide.
MelperoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Glutethimide.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Glutethimide.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Glutethimide.
MetaxaloneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Glutethimide.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Glutethimide.
MethapyrileneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Glutethimide.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Glutethimide.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Glutethimide.
MethsuximideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Glutethimide.
MetyrosineGlutethimide may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Glutethimide.
MilnacipranThe risk or severity of adverse effects can be increased when Glutethimide is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
MirtazapineGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Glutethimide.
MolindoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Glutethimide.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
NabiloneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nabilone.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Glutethimide.
NitrazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Glutethimide.
OpiumThe risk or severity of adverse effects can be increased when Glutethimide is combined with Opium.
OrphenadrineGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Glutethimide.
OsanetantThe risk or severity of adverse effects can be increased when Glutethimide is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Glutethimide.
OxprenololThe risk or severity of adverse effects can be increased when Glutethimide is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Glutethimide.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Glutethimide.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Glutethimide.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Glutethimide.
ParaldehydeGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Glutethimide.
ParoxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Glutethimide.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Glutethimide.
PerampanelThe risk or severity of adverse effects can be increased when Glutethimide is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Glutethimide is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Glutethimide.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Glutethimide.
PhenindioneThe metabolism of Phenindione can be increased when combined with Glutethimide.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Glutethimide.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenoxyethanol.
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Glutethimide.
PhenytoinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Glutethimide.
PipamperoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pomalidomide.
PramipexoleGlutethimide may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Glutethimide.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Glutethimide.
PrimidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Glutethimide.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Glutethimide.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Glutethimide.
PromethazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Glutethimide.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Glutethimide.
PropoxycaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Glutethimide is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Glutethimide.
RamelteonThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ramelteon.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Glutethimide.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Glutethimide.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Glutethimide.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Glutethimide.
RomifidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Romifidine.
RopiniroleGlutethimide may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Glutethimide.
RotigotineGlutethimide may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Glutethimide.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Glutethimide is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Glutethimide.
SertindoleThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Glutethimide.
Sodium oxybateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sodium oxybate.
StiripentolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Glutethimide.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Glutethimide.
SuvorexantThe risk or severity of adverse effects can be increased when Glutethimide is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tasimelteon.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Glutethimide.
TetrabenazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetrodotoxin.
ThalidomideGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Glutethimide.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Glutethimide.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Glutethimide.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Glutethimide.
ThiothixeneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tiletamine.
TizanidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Glutethimide.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Glutethimide.
TrazodoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Glutethimide.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Glutethimide.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Glutethimide.
TrimipramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Glutethimide.
VigabatrinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Vilazodone.
VortioxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Vortioxetine.
WarfarinThe metabolism of Warfarin can be increased when combined with Glutethimide.
XylazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Glutethimide.
ZiconotideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Glutethimide.
ZolazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Glutethimide.
ZonisamideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Glutethimide.
ZotepineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By si...
Gene Name:
GABRA1
Uniprot ID:
P14867
Molecular Weight:
51801.395 Da
References
  1. Skerritt JH, Johnston GA: Interactions of some anaesthetic, convulsant, and anticonvulsant drugs at GABA-benzodiazepine receptor-ionophore complexes in rat brain synaptosomal membranes. Neurochem Res. 1983 Oct;8(10):1351-62. [PubMed:6318143 ]
Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. ChEMBL Compound Report Card [Link]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name:
CYP11A1
Uniprot ID:
P05108
Molecular Weight:
60101.87 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Pearson MW, Roberts CJ: Drug induction of hepatic enzymes in the elderly. Age Ageing. 1984 Sep;13(5):313-6. [PubMed:6496244 ]
  2. Petik D, Acs N, Banhidy F, Czeizel AE: A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetuses. Toxicol Ind Health. 2008 Feb-Mar;24(1-2):69-78. doi: 10.1177/0748233708089014. [PubMed:18818183 ]
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Drug created on July 26, 2007 13:33 / Updated on August 17, 2016 12:23