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Identification
NameCarfentanil
Accession NumberDB01535
TypeSmall Molecule
GroupsIllicit, Vet Approved
DescriptionCarfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl, with activity in humans starting at about 1 microgram. It is marketed under the trade name Wildnil as a general anaesthetic agent for large animals. Carfentanil is intended for large-animal use only as its extreme potency makes it inappropriate for use in humans. Currently sufentanil, approximately 10–20 times less potent (500 to 1000 times the efficacy of morphine per weight) than carfentanil, is the maximum strength fentanyl analog for use in humans.
Structure
Thumb
Synonyms
Carfentanyl
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Carfentanil citrate
ThumbNot applicableDBSALT001611
Categories
UNIILA9DTA2L8F
CAS number59708-52-0
WeightAverage: 394.5066
Monoisotopic: 394.225642836
Chemical FormulaC24H30N2O3
InChI KeyYDSDEBIZUNNPOB-UHFFFAOYSA-N
InChI
InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3
IUPAC Name
methyl 1-(2-phenylethyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate
SMILES
CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC2=CC=CC=C2)CC1)C(=O)OC
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as fentanyls. These are compounds containing the fentanyl moiety or a derivative, which is based on a N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide skeleton.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPiperidines
Sub ClassFentanyls
Direct ParentFentanyls
Alternative Parents
Substituents
  • Fentanyl
  • Alpha-amino acid or derivatives
  • Anilide
  • Piperidinecarboxylic acid
  • Phenethylamine
  • Aralkylamine
  • 4-aminopiperidine
  • Benzenoid
  • Monocyclic benzene moiety
  • Methyl ester
  • Tertiary carboxylic acid amide
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxylic acid ester
  • Carboxamide group
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationCarfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals.
PharmacodynamicsCarfentanil acts primarily on the mu (some kappa and delta) opioid receptors as an agonist. It will induce similar effects of analgesia as other opioids, however, due to its potency, it will also induce strong side effects such as sedation. Consequently, that is why it is used as a tranquilizer for large animals. Carfentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the brain, spinal cord, and other tissues. It exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Carfentanil also depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.
Mechanism of actionCarfentanil binds very strongly to mu opioid receptors and acts as a competitive agonist. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
Pathways
PathwayCategorySMPDB ID
Carfentanil Action PathwayDrug actionSMP00414
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8605
Blood Brain Barrier+0.9762
Caco-2 permeable-0.5069
P-glycoprotein substrateSubstrate0.7011
P-glycoprotein inhibitor IInhibitor0.8424
P-glycoprotein inhibitor IINon-inhibitor0.6298
Renal organic cation transporterNon-inhibitor0.6504
CYP450 2C9 substrateNon-substrate0.8368
CYP450 2D6 substrateNon-substrate0.8791
CYP450 3A4 substrateSubstrate0.6667
CYP450 1A2 substrateNon-inhibitor0.9279
CYP450 2C9 inhibitorNon-inhibitor0.7664
CYP450 2D6 inhibitorNon-inhibitor0.8561
CYP450 2C19 inhibitorNon-inhibitor0.7325
CYP450 3A4 inhibitorNon-inhibitor0.6284
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6023
Ames testNon AMES toxic0.7779
CarcinogenicityNon-carcinogens0.869
BiodegradationNot ready biodegradable0.9474
Rat acute toxicity2.9219 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9613
hERG inhibition (predictor II)Inhibitor0.6716
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0259 mg/mLALOGPS
logP3.7ALOGPS
logP3.67ChemAxon
logS-4.2ALOGPS
pKa (Strongest Basic)8.05ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area49.85 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity114.38 m3·mol-1ChemAxon
Polarizability44.6 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Louis P. Reiff, Paul B. Sollman, “Process of making carfentanil and related analgesics.” U.S. Patent US5106983, issued January, 1981.

US5106983
General References
  1. Wax PM, Becker CE, Curry SC: Unexpected "gas" casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5. [PubMed:12712038 ]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Carfentanil.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Carfentanil.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with 7-Nitroindazole.
AcepromazineAcepromazine may increase the hypotensive activities of Carfentanil.
AcepromazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Aceprometazine.
AcetazolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Acetazolamide.
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Carfentanil.
adipiplonThe risk or severity of adverse effects can be increased when Carfentanil is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Carfentanil.
AlimemazineAlimemazine may increase the hypotensive activities of Carfentanil.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Carfentanil.
AlvimopanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alvimopan.
AmilorideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amiloride.
AmisulprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amitriptyline.
Ammonium chlorideAmmonium chloride may increase the excretion rate of Carfentanil which could result in a higher serum level.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Carfentanil.
AmoxapineCarfentanil may increase the serotonergic activities of Amoxapine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Carfentanil.
AmperozideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amperozide.
AmphetamineAmphetamine may increase the analgesic activities of Carfentanil.
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Carfentanil.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Carfentanil.
ArticaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Asenapine.
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Carfentanil.
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Carfentanil.
AzaperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Azaperone.
AzelastineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Carfentanil.
AzosemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Azosemide.
BaclofenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Carfentanil.
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Carfentanil.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bendroflumethiazide.
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Carfentanil.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Carfentanil.
BenzphetamineBenzphetamine may increase the analgesic activities of Carfentanil.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Carfentanil is combined with Benzyl alcohol.
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Carfentanil.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
BrimonidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brotizolam.
BumetanideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bumetanide.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Carfentanil.
BuprenorphineBuprenorphine may decrease the analgesic activities of Carfentanil.
BuprenorphineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Carfentanil.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Carfentanil.
ButacaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Carfentanil.
ButorphanolButorphanol may decrease the analgesic activities of Carfentanil.
ButorphanolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butorphanol.
Canrenoic acidThe risk or severity of adverse effects can be increased when Carfentanil is combined with Canrenoic acid.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Carfentanil.
CarbinoxamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Carbinoxamine.
CarisoprodolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carfentanil.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Carfentanil.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Carfentanil.
ChlorothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorothiazide.
ChlorphenamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorphenamine.
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Carfentanil.
ChlorphentermineChlorphentermine may increase the analgesic activities of Carfentanil.
ChlorpromazineChlorpromazine may increase the hypotensive activities of Carfentanil.
ChlorpromazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Carfentanil.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorthalidone.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Carfentanil.
CitalopramCarfentanil may increase the serotonergic activities of Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with clomethiazole.
ClomipramineCarfentanil may increase the serotonergic activities of Clomipramine.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Carfentanil.
ClonazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Carfentanil.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Carfentanil.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Carfentanil.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Carfentanil.
ConivaptanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Conivaptan.
CyclizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Carfentanil.
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Carfentanil.
CyclothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyclothiazide.
CyproheptadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Carfentanil.
DapoxetineCarfentanil may increase the serotonergic activities of Dapoxetine.
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Carfentanil.
deramciclaneThe risk or severity of adverse effects can be increased when Carfentanil is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Carfentanil.
DesipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Carfentanil.
DesmopressinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Desmopressin.
DetomidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dexbrompheniramine.
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Carfentanil.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Carfentanil.
DextroamphetamineDextroamphetamine may increase the analgesic activities of Carfentanil.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Carfentanil.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Carfentanil.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Carfentanil.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Carfentanil.
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Carfentanil.
DifenoxinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Carfentanil.
DihydromorphineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carfentanil.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Carfentanil.
DoramectinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
DoxylamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Carfentanil is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Carfentanil.
DrospirenoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Drospirenone.
DrotebanolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Carfentanil.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Carfentanil.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Carfentanil is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Carfentanil is combined with Efavirenz.
EfonidipineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Efonidipine.
EluxadolineCarfentanil may increase the constipating activities of Eluxadoline.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Carfentanil.
EntacaponeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Entacapone.
EplerenoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Eplerenone.
EscitalopramCarfentanil may increase the serotonergic activities of Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Carfentanil.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Carfentanil.
Etacrynic acidThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etacrynic acid.
EthanolCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Carfentanil.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Carfentanil.
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Carfentanil.
EthosuximideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethotoin.
EthoxzolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethoxzolamide.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Carfentanil.
EtidocaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Carfentanil.
EtoperidoneCarfentanil may increase the serotonergic activities of Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Carfentanil.
EzogabineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Carfentanil.
FenfluramineCarfentanil may increase the serotonergic activities of Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Carfentanil.
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Carfentanil.
FexofenadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flunitrazepam.
FluoxetineCarfentanil may increase the serotonergic activities of Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Carfentanil.
FluphenazineFluphenazine may increase the hypotensive activities of Carfentanil.
FluphenazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Carfentanil.
FluspirileneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluticasone Propionate.
FluvoxamineCarfentanil may increase the serotonergic activities of Fluvoxamine.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Carfentanil.
FosphenytoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fospropofol.
FurosemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Furosemide.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Carfentanil.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Carfentanil is combined with gabapentin enacarbil.
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Carfentanil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Carfentanil.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carfentanil.
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Carfentanil.
GuanfacineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Carfentanil.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Carfentanil.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Carfentanil.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Carfentanil.
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Carfentanil.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Carfentanil.
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Carfentanil.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Hydrochlorothiazide.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Carfentanil.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Hydroflumethiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Carfentanil.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Carfentanil.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
HydroxyzineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Hydroxyzine.
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Carfentanil.
IloperidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Imipramine.
IndalpineCarfentanil may increase the serotonergic activities of Indalpine.
IndapamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Indapamide.
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Carfentanil.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Carfentanil.
IsosorbideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Isosorbide.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Carfentanil.
KetazolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ketobemidone.
KW-3902The risk or severity of adverse effects can be increased when Carfentanil is combined with KW-3902.
LamotrigineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Carfentanil.
LevocabastineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Carfentanil.
LevomilnacipranCarfentanil may increase the serotonergic activities of Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Carfentanil.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carfentanil.
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Carfentanil.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Carfentanil.
LofentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carfentanil.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Carfentanil.
Lu AA21004Carfentanil may increase the serotonergic activities of Lu AA21004.
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Carfentanil.
LurasidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Magnesium Sulfate.
MannitolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mannitol.
MaprotilineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Maprotiline.
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Carfentanil.
MeclizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Carfentanil.
MelperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Melperone.
MephentermineMephentermine may increase the analgesic activities of Carfentanil.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Carfentanil.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Carfentanil.
MersalylThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mersalyl.
MesoridazineMesoridazine may increase the hypotensive activities of Carfentanil.
MesoridazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Carfentanil.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carfentanil.
MethamphetamineMethamphetamine may increase the analgesic activities of Carfentanil.
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Carfentanil.
MethapyrileneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methaqualone.
MethazolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methazolamide.
MethocarbamolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Carfentanil.
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Carfentanil.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Carfentanil.
MethsuximideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methsuximide.
MethyclothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methyclothiazide.
Methylene blueMethylene blue may increase the hypotensive activities of Carfentanil.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Carfentanil.
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Carfentanil.
MetolazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Metolazone.
MetyrosineCarfentanil may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Carfentanil.
MilnacipranCarfentanil may increase the serotonergic activities of Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
MirtazapineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Carfentanil.
MolindoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Molindone.
MoricizineMoricizine may increase the hypotensive activities of Carfentanil.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Carfentanil.
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Carfentanil.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
NabiloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nabilone.
NalbuphineNalbuphine may decrease the analgesic activities of Carfentanil.
NalbuphineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nalbuphine.
NaltrexoneThe therapeutic efficacy of Carfentanil can be decreased when used in combination with Naltrexone.
NitrazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nortriptyline.
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Carfentanil.
OlanzapineCarfentanil may increase the serotonergic activities of Olanzapine.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Carfentanil.
OlopatadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Carfentanil.
OpiumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Opium.
OrphenadrineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Carfentanil.
OsanetantThe risk or severity of adverse effects can be increased when Carfentanil is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Carfentanil.
OxprenololThe risk or severity of adverse effects can be increased when Carfentanil is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Carfentanil.
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Carfentanil.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Carfentanil.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Carfentanil.
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Carfentanil.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Carfentanil.
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Carfentanil.
ParaldehydeCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Carfentanil.
ParoxetineCarfentanil may increase the serotonergic activities of Paroxetine.
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Carfentanil.
PentazocinePentazocine may decrease the analgesic activities of Carfentanil.
PentazocineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Carfentanil.
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Carfentanil.
PerampanelThe risk or severity of adverse effects can be increased when Carfentanil is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Perospirone.
PerphenazinePerphenazine may increase the hypotensive activities of Carfentanil.
PerphenazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Carfentanil.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Carfentanil.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenoxyethanol.
PhenterminePhentermine may increase the analgesic activities of Carfentanil.
PhenytoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Carfentanil.
PipamperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pipamperone.
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Carfentanil.
PipotiazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pipotiazine.
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Carfentanil.
PiretanideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Piretanide.
PizotifenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pizotifen.
PolythiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Polythiazide.
PomalidomideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pomalidomide.
PotassiumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Potassium.
Potassium CitrateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Potassium Citrate.
PramipexoleCarfentanil may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carfentanil.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Carfentanil.
PrimidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Carfentanil.
ProchlorperazineProchlorperazine may increase the hypotensive activities of Carfentanil.
ProchlorperazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Carfentanil.
PromazinePromazine may increase the hypotensive activities of Carfentanil.
PromazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Promazine.
PromethazinePromethazine may increase the hypotensive activities of Carfentanil.
PromethazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Promethazine.
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Carfentanil.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Carfentanil.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Carfentanil.
PropoxycaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Carfentanil is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Carfentanil.
QuinethazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Quinethazone.
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Carfentanil.
RamelteonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ramelteon.
RamosetronCarfentanil may increase the constipating activities of Ramosetron.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Carfentanil.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Carfentanil.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Carfentanil.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Carfentanil.
RomifidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Romifidine.
RopiniroleCarfentanil may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Carfentanil.
RotigotineCarfentanil may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Carfentanil.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Carfentanil is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Carfentanil.
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Carfentanil.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Carfentanil.
SertindoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with Sertindole.
SertralineCarfentanil may increase the serotonergic activities of Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Carfentanil.
Sodium oxybateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Sodium oxybate.
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Carfentanil.
SpironolactoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Spironolactone.
StiripentolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Stiripentol.
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Carfentanil.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Carfentanil.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Carfentanil.
SuvorexantThe risk or severity of adverse effects can be increased when Carfentanil is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tasimelteon.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Carfentanil.
TetrabenazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetrodotoxin.
ThalidomideCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Carfentanil.
TheobromineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Theobromine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Carfentanil.
ThiethylperazineThiethylperazine may increase the hypotensive activities of Carfentanil.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Carfentanil.
ThioridazineThioridazine may increase the hypotensive activities of Carfentanil.
ThioridazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tiagabine.
TicrynafenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ticrynafen.
TiletamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tiletamine.
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Carfentanil.
TizanidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tolcapone.
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Carfentanil.
TolvaptanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tolvaptan.
TopiramateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Topiramate.
TorasemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Torasemide.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Carfentanil.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Carfentanil.
TrazodoneCarfentanil may increase the serotonergic activities of Trazodone.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Carfentanil.
TriamtereneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Triamterene.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Carfentanil.
TrichlormethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trichlormethiazide.
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Carfentanil.
TrifluoperazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trifluoperazine.
TriflupromazineTriflupromazine may increase the hypotensive activities of Carfentanil.
TriflupromazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Triflupromazine.
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Carfentanil.
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Carfentanil.
TrimipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Triprolidine.
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Carfentanil.
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Carfentanil.
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Carfentanil.
UlaritideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ularitide.
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Carfentanil.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Carfentanil.
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Carfentanil.
VigabatrinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Vigabatrin.
VilazodoneCarfentanil may increase the serotonergic activities of Vilazodone.
VortioxetineCarfentanil may increase the serotonergic activities of Vortioxetine.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Carfentanil.
XylazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Carfentanil.
ZiconotideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ziconotide.
ZimelidineCarfentanil may increase the serotonergic activities of Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Carfentanil.
ZolazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Carfentanil.
ZonisamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Carfentanil.
ZotepineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Bencherif B, Wand GS, McCaul ME, Kim YK, Ilgin N, Dannals RF, Frost JJ: Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence. Biol Psychiatry. 2004 Feb 1;55(3):255-62. [PubMed:14744466 ]
  2. Bencherif B, Stumpf MJ, Links JM, Frost JJ: Application of MRI-based partial-volume correction to the analysis of PET images of mu-opioid receptors using statistical parametric mapping. J Nucl Med. 2004 Mar;45(3):402-8. [PubMed:15001679 ]
  3. Jewett DM, Kilbourn MR: In vivo evaluation of new carfentanil-based radioligands for the mu opiate receptor. Nucl Med Biol. 2004 Apr;31(3):321-5. [PubMed:15028244 ]
  4. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  5. Bartenstein PA, Prevett MC, Duncan JS, Hajek M, Wieser HG: Quantification of opiate receptors in two patients with mesiobasal temporal lobe epilepsy, before and after selective amygdalohippocampectomy, using positron emission tomography. Epilepsy Res. 1994 Jun;18(2):119-25. [PubMed:7957034 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurot...
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular Weight:
40368.235 Da
References
  1. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  2. Barry U, Zuo Z: Opioids: old drugs for potential new applications. Curr Pharm Des. 2005;11(10):1343-50. [PubMed:15853689 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  2. Barry U, Zuo Z: Opioids: old drugs for potential new applications. Curr Pharm Des. 2005;11(10):1343-50. [PubMed:15853689 ]
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Drug created on July 31, 2007 07:10 / Updated on August 17, 2016 12:23