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Identification
NameChlorphentermine
Accession NumberDB01556
TypeSmall Molecule
GroupsIllicit, Withdrawn
DescriptionA sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
Structure
Thumb
Synonyms
4-Chloro-a,a-dimethylbenzeneethanamine
4-Chloro-a,a-dimethylphenethylamine
a,a-Dimethyl-p-chlorophenethylamine
Chlorphenterminum
Clorfentermina
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ApsedonNot Available
DesopimonNot Available
LucofenNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Chlorphentermine hydrochloride
Thumb
  • InChI Key: WEJDYJKJPUPMLH-UHFFFAOYSA-N
  • Monoisotopic Mass: 219.058154899
  • Average Mass: 220.139
DBSALT000815
Categories
UNIINHW07912O7
CAS number461-78-9
WeightAverage: 183.678
Monoisotopic: 183.08147716
Chemical FormulaC10H14ClN
InChI KeyInChIKey=ZCKAMNXUHHNZLN-UHFFFAOYSA-N
InChI
InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3
IUPAC Name
1-(4-chlorophenyl)-2-methylpropan-2-amine
SMILES
CC(C)(N)CC1=CC=C(Cl)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenethylamines
Direct ParentAmphetamines and derivatives
Alternative Parents
Substituents
  • Amphetamine or derivatives
  • Phenylpropane
  • Aralkylamine
  • Halobenzene
  • Chlorobenzene
  • Aryl halide
  • Aryl chloride
  • Hydrocarbon derivative
  • Primary amine
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Primary aliphatic amine
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationUsed as an appetite suppressant.
PharmacodynamicsChlorphentermine is a relatively weak stimulant with little abuse potential. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.
Mechanism of actionNot Available
Related Articles
AbsorptionWell absorbed following oral administration.
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half life40 hours
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9966
Blood Brain Barrier+0.9792
Caco-2 permeable+0.7531
P-glycoprotein substrateNon-substrate0.6627
P-glycoprotein inhibitor INon-inhibitor0.9092
P-glycoprotein inhibitor IINon-inhibitor0.9805
Renal organic cation transporterNon-inhibitor0.8185
CYP450 2C9 substrateNon-substrate0.8464
CYP450 2D6 substrateSubstrate0.5148
CYP450 3A4 substrateNon-substrate0.5233
CYP450 1A2 substrateInhibitor0.6449
CYP450 2C9 inhibitorNon-inhibitor0.8526
CYP450 2D6 inhibitorInhibitor0.8286
CYP450 2C19 inhibitorNon-inhibitor0.752
CYP450 3A4 inhibitorNon-inhibitor0.5737
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7748
Ames testNon AMES toxic0.8728
CarcinogenicityNon-carcinogens0.6055
BiodegradationNot ready biodegradable0.9895
Rat acute toxicity2.8974 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9818
hERG inhibition (predictor II)Non-inhibitor0.738
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
boiling point100-102 °C at 2.00E+00 mm HgNot Available
logP2.60HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.105 mg/mLALOGPS
logP2.81ALOGPS
logP2.69ChemAxon
logS-3.2ALOGPS
pKa (Strongest Basic)10.24ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area26.02 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity53.15 m3·mol-1ChemAxon
Polarizability20.19 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73. [PubMed:13903304 ]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypertensive activities of Chlorphentermine.
AcebutololThe risk or severity of adverse effects can be increased when Acebutolol is combined with Chlorphentermine.
AcepromazineAcepromazine may decrease the stimulatory activities of Chlorphentermine.
AceprometazineAceprometazine may decrease the stimulatory activities of Chlorphentermine.
AcetazolamideAcetazolamide may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
AcetophenazineAcetophenazine may decrease the stimulatory activities of Chlorphentermine.
AcrivastineChlorphentermine may decrease the sedative activities of Acrivastine.
AlcaftadineChlorphentermine may decrease the sedative activities of Alcaftadine.
AlfentanilChlorphentermine may increase the analgesic activities of Alfentanil.
AlimemazineChlorphentermine may decrease the sedative activities of Alimemazine.
AlphacetylmethadolChlorphentermine may increase the analgesic activities of Alphacetylmethadol.
Aluminum hydroxideAluminum hydroxide may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
Aluminum phosphateAluminum phosphate may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
AmineptineAmineptine may increase the stimulatory activities of Chlorphentermine.
AmisulprideAmisulpride may decrease the stimulatory activities of Chlorphentermine.
AmitriptylineAmitriptyline may increase the stimulatory activities of Chlorphentermine.
Ammonium chlorideThe serum concentration of Chlorphentermine can be decreased when it is combined with Ammonium chloride.
AmperozideAmperozide may decrease the stimulatory activities of Chlorphentermine.
AmphetamineThe risk or severity of adverse effects can be increased when Amphetamine is combined with Chlorphentermine.
AntazolineChlorphentermine may decrease the sedative activities of Antazoline.
AripiprazoleAripiprazole may decrease the stimulatory activities of Chlorphentermine.
AsenapineAsenapine may decrease the stimulatory activities of Chlorphentermine.
AstemizoleChlorphentermine may decrease the sedative activities of Astemizole.
AtomoxetineAtomoxetine may increase the hypertensive activities of Chlorphentermine.
AzaperoneAzaperone may decrease the stimulatory activities of Chlorphentermine.
AzatadineChlorphentermine may decrease the sedative activities of Azatadine.
AzelastineChlorphentermine may decrease the sedative activities of Azelastine.
BenmoxinBenmoxin may increase the hypertensive activities of Chlorphentermine.
BenzphetamineThe risk or severity of adverse effects can be increased when Benzphetamine is combined with Chlorphentermine.
BezitramideChlorphentermine may increase the analgesic activities of Bezitramide.
BifeprunoxBifeprunox may decrease the stimulatory activities of Chlorphentermine.
Bismuth SubcitrateBismuth Subcitrate may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
BrexpiprazoleBrexpiprazole may decrease the stimulatory activities of Chlorphentermine.
BrompheniramineChlorphentermine may decrease the sedative activities of Brompheniramine.
BuclizineChlorphentermine may decrease the sedative activities of Buclizine.
BuprenorphineChlorphentermine may increase the analgesic activities of Buprenorphine.
Butanoic AcidChlorphentermine may decrease the sedative activities of Butanoic Acid.
ButorphanolChlorphentermine may increase the analgesic activities of Butorphanol.
Calcium carbonateCalcium carbonate may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
CarbinoxamineChlorphentermine may decrease the sedative activities of Carbinoxamine.
CarfentanilChlorphentermine may increase the analgesic activities of Carfentanil.
CariprazineCariprazine may decrease the stimulatory activities of Chlorphentermine.
CaroxazoneCaroxazone may increase the hypertensive activities of Chlorphentermine.
CeliprololThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Celiprolol.
CetirizineChlorphentermine may decrease the sedative activities of Cetirizine.
ChloropyramineChlorphentermine may decrease the sedative activities of Chloropyramine.
ChlorphenamineChlorphentermine may decrease the sedative activities of Chlorphenamine.
ChlorphenoxamineChlorphentermine may decrease the sedative activities of Chlorphenoxamine.
ChlorpromazineChlorpromazine may decrease the stimulatory activities of Chlorphentermine.
ChlorprothixeneChlorprothixene may decrease the stimulatory activities of Chlorphentermine.
CimetidineChlorphentermine may decrease the sedative activities of Cimetidine.
CinnarizineChlorphentermine may decrease the sedative activities of Cinnarizine.
ClemastineChlorphentermine may decrease the sedative activities of Clemastine.
ClenbuterolThe risk or severity of adverse effects can be increased when Clenbuterol is combined with Chlorphentermine.
ClomipramineClomipramine may increase the stimulatory activities of Chlorphentermine.
ClozapineClozapine may decrease the stimulatory activities of Chlorphentermine.
CodeineChlorphentermine may increase the analgesic activities of Codeine.
CyamemazineCyamemazine may decrease the stimulatory activities of Chlorphentermine.
CyclizineChlorphentermine may decrease the sedative activities of Cyclizine.
CyclobenzaprineCyclobenzaprine may increase the stimulatory activities of Chlorphentermine.
CyproheptadineChlorphentermine may decrease the sedative activities of Cyproheptadine.
DapiprazoleDapiprazole may decrease the stimulatory activities of Chlorphentermine.
DesipramineDesipramine may increase the stimulatory activities of Chlorphentermine.
DesloratadineChlorphentermine may decrease the sedative activities of Desloratadine.
DexbrompheniramineChlorphentermine may decrease the sedative activities of Dexbrompheniramine.
Dexchlorpheniramine maleateChlorphentermine may decrease the sedative activities of Dexchlorpheniramine maleate.
DextromoramideChlorphentermine may increase the analgesic activities of Dextromoramide.
DextropropoxypheneChlorphentermine may increase the analgesic activities of Dextropropoxyphene.
DezocineChlorphentermine may increase the analgesic activities of Dezocine.
DiclofenamideDiclofenamide may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
DihydrocodeineChlorphentermine may increase the analgesic activities of Dihydrocodeine.
DihydroetorphineChlorphentermine may increase the analgesic activities of Dihydroetorphine.
DihydromorphineChlorphentermine may increase the analgesic activities of Dihydromorphine.
DimenhydrinateChlorphentermine may decrease the sedative activities of Dimenhydrinate.
DimetindeneChlorphentermine may decrease the sedative activities of Dimetindene.
DimetotiazineChlorphentermine may decrease the sedative activities of Dimetotiazine.
DiphenhydramineChlorphentermine may decrease the sedative activities of Diphenhydramine.
DiphenoxylateChlorphentermine may increase the analgesic activities of Diphenoxylate.
DobutamineThe risk or severity of adverse effects can be increased when Dobutamine is combined with Chlorphentermine.
DopamineThe risk or severity of adverse effects can be increased when Dopamine is combined with Chlorphentermine.
DosulepinDosulepin may increase the stimulatory activities of Chlorphentermine.
DoxepinChlorphentermine may decrease the sedative activities of Doxepin.
DoxepinDoxepin may increase the stimulatory activities of Chlorphentermine.
DoxofyllineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Doxofylline.
DoxylamineChlorphentermine may decrease the sedative activities of Doxylamine.
DPDPEChlorphentermine may increase the analgesic activities of DPDPE.
DronabinolDronabinol may increase the tachycardic activities of Chlorphentermine.
DroperidolDroperidol may decrease the stimulatory activities of Chlorphentermine.
EmedastineChlorphentermine may decrease the sedative activities of Emedastine.
EphedrineThe risk or severity of adverse effects can be increased when Ephedrine is combined with Chlorphentermine.
EpinastineChlorphentermine may decrease the sedative activities of Epinastine.
EpinephrineThe risk or severity of adverse effects can be increased when Epinephrine is combined with Chlorphentermine.
EsmirtazapineChlorphentermine may decrease the sedative activities of Esmirtazapine.
EsmirtazapineEsmirtazapine may increase the stimulatory activities of Chlorphentermine.
EthopropazineChlorphentermine may decrease the sedative activities of Ethopropazine.
EthosuximideThe therapeutic efficacy of Ethosuximide can be decreased when used in combination with Chlorphentermine.
EthoxzolamideEthoxzolamide may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
EthylmorphineChlorphentermine may increase the analgesic activities of Ethylmorphine.
EtilefrineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Etilefrine.
EtorphineChlorphentermine may increase the analgesic activities of Etorphine.
FamotidineChlorphentermine may decrease the sedative activities of Famotidine.
FencamfamineFencamfamine may decrease the stimulatory activities of Chlorphentermine.
FenoterolThe risk or severity of adverse effects can be increased when Fenoterol is combined with Chlorphentermine.
FentanylChlorphentermine may increase the analgesic activities of Fentanyl.
FexofenadineChlorphentermine may decrease the sedative activities of Fexofenadine.
FlunarizineChlorphentermine may decrease the sedative activities of Flunarizine.
FlupentixolFlupentixol may decrease the stimulatory activities of Chlorphentermine.
FluphenazineFluphenazine may decrease the stimulatory activities of Chlorphentermine.
FluspirileneFluspirilene may decrease the stimulatory activities of Chlorphentermine.
FurazolidoneFurazolidone may increase the hypertensive activities of Chlorphentermine.
GuanethidineThe serum concentration of Chlorphentermine can be decreased when it is combined with Guanethidine.
HaloperidolHaloperidol may decrease the stimulatory activities of Chlorphentermine.
HeroinChlorphentermine may increase the analgesic activities of Heroin.
HexamethylenetetramineThe serum concentration of Chlorphentermine can be decreased when it is combined with Hexamethylenetetramine.
HydracarbazineHydracarbazine may increase the hypertensive activities of Chlorphentermine.
HydrocodoneChlorphentermine may increase the analgesic activities of Hydrocodone.
HydromorphoneChlorphentermine may increase the analgesic activities of Hydromorphone.
Hydroxyamphetamine hydrobromideThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Hydroxyamphetamine hydrobromide.
HydroxyzineChlorphentermine may decrease the sedative activities of Hydroxyzine.
IloperidoneIloperidone may decrease the stimulatory activities of Chlorphentermine.
ImipramineImipramine may increase the stimulatory activities of Chlorphentermine.
Ioflupane I-123Chlorphentermine may decrease effectiveness of Ioflupane I 123 as a diagnostic agent.
IproclozideIproclozide may increase the hypertensive activities of Chlorphentermine.
IproniazidIproniazid may increase the hypertensive activities of Chlorphentermine.
IsocarboxazidIsocarboxazid may increase the hypertensive activities of Chlorphentermine.
IsoprenalineThe risk or severity of adverse effects can be increased when Isoprenaline is combined with Chlorphentermine.
IsothipendylChlorphentermine may decrease the sedative activities of Isothipendyl.
IsoxsuprineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Isoxsuprine.
KetobemidoneChlorphentermine may increase the analgesic activities of Ketobemidone.
KetotifenChlorphentermine may decrease the sedative activities of Ketotifen.
L-Glutamic AcidThe serum concentration of Chlorphentermine can be decreased when it is combined with L-Glutamic Acid.
LabetalolThe risk or severity of adverse effects can be increased when Labetalol is combined with Chlorphentermine.
LevocabastineChlorphentermine may decrease the sedative activities of Levocabastine.
LevocetirizineChlorphentermine may decrease the sedative activities of Levocetirizine.
Levomethadyl AcetateChlorphentermine may increase the analgesic activities of Levomethadyl Acetate.
LevorphanolChlorphentermine may increase the analgesic activities of Levorphanol.
LinezolidLinezolid may increase the hypertensive activities of Chlorphentermine.
LithiumLithium may decrease the stimulatory activities of Chlorphentermine.
LodoxamideChlorphentermine may decrease the sedative activities of Lodoxamide.
LofentanilChlorphentermine may increase the analgesic activities of Lofentanil.
LoratadineChlorphentermine may decrease the sedative activities of Loratadine.
LoxapineLoxapine may decrease the stimulatory activities of Chlorphentermine.
LurasidoneLurasidone may decrease the stimulatory activities of Chlorphentermine.
MagaldrateMagaldrate may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium carbonateMagnesium carbonate may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium hydroxideMagnesium hydroxide may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium oxideMagnesium oxide may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium TrisilicateMagnesium Trisilicate may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
MebanazineMebanazine may increase the hypertensive activities of Chlorphentermine.
MeclizineChlorphentermine may decrease the sedative activities of Meclizine.
MelperoneMelperone may decrease the stimulatory activities of Chlorphentermine.
MephentermineThe risk or severity of adverse effects can be increased when Mephentermine is combined with Chlorphentermine.
MepyramineChlorphentermine may decrease the sedative activities of Mepyramine.
MequitazineChlorphentermine may decrease the sedative activities of Mequitazine.
MesoridazineMesoridazine may decrease the stimulatory activities of Chlorphentermine.
MetaraminolThe risk or severity of adverse effects can be increased when Metaraminol is combined with Chlorphentermine.
MethadoneChlorphentermine may increase the analgesic activities of Methadone.
Methadyl AcetateChlorphentermine may increase the analgesic activities of Methadyl Acetate.
MethamphetamineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Methamphetamine.
MethapyrileneChlorphentermine may decrease the sedative activities of Methapyrilene.
MethazolamideMethazolamide may decrease the excretion rate of Chlorphentermine which could result in a lower serum level and potentially a reduction in efficacy.
MethotrimeprazineMethotrimeprazine may decrease the stimulatory activities of Chlorphentermine.
MethoxamineThe risk or severity of adverse effects can be increased when Methoxamine is combined with Chlorphentermine.
Methylene blueMethylene blue may increase the hypertensive activities of Chlorphentermine.
MetiamideChlorphentermine may decrease the sedative activities of Metiamide.
MianserinChlorphentermine may decrease the sedative activities of Mianserin.
MidodrineThe risk or severity of adverse effects can be increased when Midodrine is combined with Chlorphentermine.
MinaprineMinaprine may increase the hypertensive activities of Chlorphentermine.
MirtazapineChlorphentermine may decrease the sedative activities of Mirtazapine.
MirtazapineMirtazapine may increase the stimulatory activities of Chlorphentermine.
MoclobemideMoclobemide may increase the hypertensive activities of Chlorphentermine.
MolindoneMolindone may decrease the stimulatory activities of Chlorphentermine.
MorphineChlorphentermine may increase the analgesic activities of Morphine.
NabiloneNabilone may increase the tachycardic activities of Chlorphentermine.
NalbuphineChlorphentermine may increase the analgesic activities of Nalbuphine.
NialamideNialamide may increase the hypertensive activities of Chlorphentermine.
NizatidineChlorphentermine may decrease the sedative activities of Nizatidine.
NorepinephrineThe risk or severity of adverse effects can be increased when Norepinephrine is combined with Chlorphentermine.
NormethadoneChlorphentermine may increase the analgesic activities of Normethadone.
NortriptylineNortriptyline may increase the stimulatory activities of Chlorphentermine.
NylidrinThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Nylidrin.
OctamoxinOctamoxin may increase the hypertensive activities of Chlorphentermine.
OlanzapineOlanzapine may decrease the stimulatory activities of Chlorphentermine.
OlopatadineChlorphentermine may decrease the sedative activities of Olopatadine.
OndansetronOndansetron may decrease the stimulatory activities of Chlorphentermine.
OpiumChlorphentermine may increase the analgesic activities of Opium.
OrciprenalineThe risk or severity of adverse effects can be increased when Orciprenaline is combined with Chlorphentermine.
OsanetantOsanetant may decrease the stimulatory activities of Chlorphentermine.
OxycodoneChlorphentermine may increase the analgesic activities of Oxycodone.
OxymetazolineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Chlorphentermine.
OxymorphoneChlorphentermine may increase the analgesic activities of Oxymorphone.
PaliperidonePaliperidone may decrease the stimulatory activities of Chlorphentermine.
PargylinePargyline may increase the hypertensive activities of Chlorphentermine.
PemirolastChlorphentermine may decrease the sedative activities of Pemirolast.
PentazocineChlorphentermine may increase the analgesic activities of Pentazocine.
PerospironePerospirone may decrease the stimulatory activities of Chlorphentermine.
PerphenazinePerphenazine may decrease the stimulatory activities of Chlorphentermine.
PethidineChlorphentermine may increase the analgesic activities of Pethidine.
PhenelzinePhenelzine may increase the hypertensive activities of Chlorphentermine.
PhenindamineChlorphentermine may decrease the sedative activities of Phenindamine.
PheniprazinePheniprazine may increase the hypertensive activities of Chlorphentermine.
PheniramineChlorphentermine may decrease the sedative activities of Pheniramine.
PhenmetrazineThe risk or severity of adverse effects can be increased when Phenmetrazine is combined with Chlorphentermine.
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Chlorphentermine.
PhenoxypropazinePhenoxypropazine may increase the hypertensive activities of Chlorphentermine.
PhentermineThe risk or severity of adverse effects can be increased when Phentermine is combined with Chlorphentermine.
PhenylephrineThe risk or severity of adverse effects can be increased when Phenylephrine is combined with Chlorphentermine.
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Chlorphentermine.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Chlorphentermine.
PimozidePimozide may decrease the stimulatory activities of Chlorphentermine.
PipamperonePipamperone may decrease the stimulatory activities of Chlorphentermine.
PipotiazinePipotiazine may decrease the stimulatory activities of Chlorphentermine.
PirlindolePirlindole may increase the hypertensive activities of Chlorphentermine.
PivhydrazinePivhydrazine may increase the hypertensive activities of Chlorphentermine.
ProcaterolThe risk or severity of adverse effects can be increased when Procaterol is combined with Chlorphentermine.
ProchlorperazineProchlorperazine may decrease the stimulatory activities of Chlorphentermine.
PromazinePromazine may decrease the stimulatory activities of Chlorphentermine.
PromethazineChlorphentermine may decrease the sedative activities of Promethazine.
PropericiazinePropericiazine may decrease the stimulatory activities of Chlorphentermine.
ProtriptylineProtriptyline may increase the stimulatory activities of Chlorphentermine.
PseudoephedrineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Pseudoephedrine.
QuetiapineQuetiapine may decrease the stimulatory activities of Chlorphentermine.
RacepinephrineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Racepinephrine.
RanitidineChlorphentermine may decrease the sedative activities of Ranitidine.
RasagilineRasagiline may increase the hypertensive activities of Chlorphentermine.
RemifentanilChlorphentermine may increase the analgesic activities of Remifentanil.
RemoxiprideRemoxipride may decrease the stimulatory activities of Chlorphentermine.
ReserpineReserpine may decrease the stimulatory activities of Chlorphentermine.
RisperidoneRisperidone may decrease the stimulatory activities of Chlorphentermine.
RitodrineThe risk or severity of adverse effects can be increased when Ritodrine is combined with Chlorphentermine.
Roxatidine acetateChlorphentermine may decrease the sedative activities of Roxatidine acetate.
SafrazineSafrazine may increase the hypertensive activities of Chlorphentermine.
SelegilineSelegiline may increase the hypertensive activities of Chlorphentermine.
SertindoleSertindole may decrease the stimulatory activities of Chlorphentermine.
Spaglumic AcidChlorphentermine may decrease the sedative activities of Spaglumic Acid.
SufentanilChlorphentermine may increase the analgesic activities of Sufentanil.
SulpirideSulpiride may decrease the stimulatory activities of Chlorphentermine.
SynephrineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Synephrine.
TapentadolChlorphentermine may increase the analgesic activities of Tapentadol.
Tedizolid PhosphateTedizolid Phosphate may increase the hypertensive activities of Chlorphentermine.
TerbutalineThe risk or severity of adverse effects can be increased when Terbutaline is combined with Chlorphentermine.
TerfenadineChlorphentermine may decrease the sedative activities of Terfenadine.
TesmilifeneChlorphentermine may decrease the sedative activities of Tesmilifene.
TetryzolineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Tetryzoline.
ThioproperazineThioproperazine may decrease the stimulatory activities of Chlorphentermine.
ThioridazineThioridazine may decrease the stimulatory activities of Chlorphentermine.
ThiothixeneThiothixene may decrease the stimulatory activities of Chlorphentermine.
ThonzylamineChlorphentermine may decrease the sedative activities of Thonzylamine.
TianeptineTianeptine may increase the stimulatory activities of Chlorphentermine.
ToloxatoneToloxatone may increase the hypertensive activities of Chlorphentermine.
TramadolChlorphentermine may increase the analgesic activities of Tramadol.
TranilastChlorphentermine may decrease the sedative activities of Tranilast.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypertensive activities of Chlorphentermine.
TranylcypromineTranylcypromine may increase the hypertensive activities of Chlorphentermine.
TrifluoperazineTrifluoperazine may decrease the stimulatory activities of Chlorphentermine.
TriflupromazineTriflupromazine may decrease the stimulatory activities of Chlorphentermine.
TrimipramineTrimipramine may increase the stimulatory activities of Chlorphentermine.
TripelennamineChlorphentermine may decrease the sedative activities of Tripelennamine.
TriprolidineChlorphentermine may decrease the sedative activities of Triprolidine.
TyramineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Tyramine.
Vitamin CThe serum concentration of Chlorphentermine can be decreased when it is combined with Vitamin C.
ZiprasidoneZiprasidone may decrease the stimulatory activities of Chlorphentermine.
ZotepineZotepine may decrease the stimulatory activities of Chlorphentermine.
ZuclopenthixolZuclopenthixol may decrease the stimulatory activities of Chlorphentermine.
Food InteractionsNot Available
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Drug created on July 31, 2007 07:10 / Updated on August 17, 2016 12:23