Kaolin

Identification

Summary

Kaolin is a natural ingredient used for the short-term symptomatic treatment of various conditions including diarrhea, skin dryness, and minor skin bleeding.

Brand Names
Gold Bond Baby Cornstarch Plus
Generic Name
Kaolin
DrugBank Accession Number
DB01575
Background

Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 258.156
Monoisotopic: 257.9024618
Chemical Formula
Al2H4O9Si2
Synonyms
  • Kaolin
  • Kaolin, light

Pharmacology

Indication

Used for upset stomach and diarrhea, a traditional medicine used in China, South America and Africa. Kaolin is also used to treat AIDs-related diarrhea. Kaolin based bandages are also under investigation.

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatDiaper rash••• •••
Used in combination for symptomatic treatment ofDiarrheaCombination Product in combination with: Pectin (DB11158)••• •••••••••••••
Used in combination to treatDiarrheaCombination Product in combination with: Neomycin (DB00994), Furazolidone (DB00614)••••••••••••••••••••••
Used in combination to treatDysenteryCombination Product in combination with: Furazolidone (DB00614), Neomycin (DB00994)••••••••••••••••••••••
Used in combination to treatEnteritis infectiousCombination Product in combination with: Neomycin (DB00994), Furazolidone (DB00614)••••••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Kaolin is an adsorptive agent.

Mechanism of action

Kaolin adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be decreased when it is combined with Kaolin.
CarbamazepineKaolin can cause a decrease in the absorption of Carbamazepine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chenodeoxycholic acidKaolin can cause a decrease in the absorption of Chenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
ChloroquineKaolin can cause a decrease in the absorption of Chloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholic AcidKaolin can cause a decrease in the absorption of Cholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Food Interactions
No interactions found.

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Derladie Vegan Pink Clay Mask Deep Pore TighteningCream25 g/100gTopicalLAON COMMERCE co ltd2023-12-01Not applicableUS flag
Dr Pore Tightening GLACIAL CLAY FACIAL MASKCream8.0 g/100mLTopicalLab & Company Inc.2017-11-01Not applicableUS flag
Dr Pore Tightening PINK CLAY FACIAL MASKCream4.0 g/100gTopicalLab & Company Inc.2017-11-01Not applicableUS flag
Druide Biolove for Diaper RashPaste4 g/100gTopicalLaboratoires Druide Inc2019-12-16Not applicableUS flag
Look At Me Mud Face Mask Mini Pack AloePaste4.5 g/30mLTopicalYoungwon Costech Co., Ltd.2018-03-30Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
2% Salicylic Acid FACIAL CLEANSERKaolin (20 mg/236mL) + Azelaic acid (10 mg/236mL) + Glycerin (50 mg/236mL) + Zinc pidolate (10 mg/236mL) + Salicylic acid (20 mg/236mL)LiquidTopicalVolans Epic LLC2023-04-06Not applicableUS flag
AXCEL KAOPEC SUSPENSIONKaolin (1 g/5ml) + Pectin (20 mg/5ml)SuspensionOralKOTRA PHARMA (M) SDN. BHD.2020-09-08Not applicableMalaysia flag
AXCEL KAOPEC SUSPENSIONKaolin (1 g/5ml) + Pectin (5 mg/5ml)SuspensionOralKOTRA PHARMA MARKETING1991-08-19Not applicableSingapore flag
BEAKOPECTIN SUSPENSIONKaolin (6000 mg/30ml) + Pectin (130 mg/30ml)SuspensionOralBEACONS PHARMACEUTICALS PTE. LTD.1991-05-23Not applicableSingapore flag
BIOGASTRIN TOZ, 60 GKaolin (300 mg) + Anise oil (5 mg) + Belladonna (20 mg) + Calcium carbonate (500 mg) + Sodium bicarbonate (250 mg)OralBİOFARMA İLAÇ SAN. VE TİC. A.Ş.1968-05-24Not applicableTurkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Derladie Vegan Pink Clay Mask Deep Pore TighteningKaolin (25 g/100g)CreamTopicalLAON COMMERCE co ltd2023-12-01Not applicableUS flag
Mefactory Pig Collagen 1step Piggy Nose PackKaolin (0.002 g/0.2g)PatchTopicalMeFactory Co., Ltd.2016-12-01Not applicableUS flag
Pore Tightening Pearl Clay MaskKaolin (30.8 g/110g)CreamTopicalRacce Co., Ltd.2018-10-012018-12-01US flag
Sonatural Facial Design Deep Black Clay MaskKaolin (3.5 g/14g)PatchTopicalSonatural Global Co.,ltd2017-10-012018-12-01US flag
Sonatural Facial Design Pink Mud MaskKaolin (2.8 g/14g)PatchTopicalSonatural Global Co.,ltd2017-03-022018-12-01US flag

Categories

ATC Codes
A07BC02 — Kaolin
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as post-transition metal silicates. These are inorganic compounds in which the largest oxoanion is silicate, and in which the heaviest atom not in an oxoanion is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal oxoanionic compounds
Sub Class
Post-transition metal silicates
Direct Parent
Post-transition metal silicates
Alternative Parents
Miscellaneous silicates / Post-transition metal salts / Metalloid salts / Inorganic salts / Inorganic oxides
Substituents
Inorganic metalloid salt / Inorganic oxide / Inorganic post-transition metal salt / Inorganic salt / Post-transition metal silicate / Silicate
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
24H4NWX5CO
CAS number
1332-58-7
InChI Key
KGOIAFZMMLWXLM-UHFFFAOYSA-N
InChI
InChI=1S/2Al.O7Si2.2H2O/c;;1-8(2,3)7-9(4,5)6;;/h;;;2*1H2/q2*+3;-6;;
IUPAC Name
dialuminium(3+) ion [(trioxidosilyl)oxy]silanetris(olate) dihydrate
SMILES
O.O.[Al+3].[Al+3].[O-][Si]([O-])([O-])O[Si]([O-])([O-])[O-]

References

Synthesis Reference

Joseph C. Muhler, Mark S. Putt, "Dentifrice preparation comprising purified, calcined kaolin abrasives." U.S. Patent US4122163, issued April, 1948.

US4122163
General References
  1. Trabattoni D, Gatto P, Bartorelli AL: A new kaolin-based hemostatic bandage use after coronary diagnostic and interventional procedures. Int J Cardiol. 2012 Apr 5;156(1):53-4. doi: 10.1016/j.ijcard.2010.10.030. Epub 2010 Nov 18. [Article]
PubChem Compound
92024769
PubChem Substance
46508763
ChemSpider
21241417
RxNav
6102
PharmGKB
PA10457
Drugs.com
Drugs.com Drug Page
Wikipedia
Kaolin
MSDS
Download (74.1 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Chattem Chemicals Inc.
  • Mallinckrodt Inc.
  • Pharmacia Inc.
Dosage Forms
FormRouteStrength
LiquidTopical
SuspensionOral
SuspensionOral1 g/5ml
SuspensionOral6000 mg/30ml
GelTopical
CreamTopical25 g/100g
CreamTopical8.0 g/100mL
CreamTopical4.0 g/100g
PasteTopical4 g/100g
LiquidOral
OintmentTopical
PasteTopical4.5 g/30mL
PatchTopical0.002 g/0.2g
Tablet, chewableOral
TabletOral
SprayTopical
CreamTopical30.8 g/110g
PowderTopical
CreamTopical
PasteTopical5 g/100mL
SolutionOral
PatchTopical3.5 g/14g
PatchTopical2.8 g/14g
CreamTopical45.5 g/130g
CreamTopical15 g/100mL
Powder
Tablet
Prices
Unit descriptionCostUnit
Kaopectate 262 mg caplet0.37USD each
Kaopectate 240 mg softgel0.25USD each
Kaolin powder0.03USD g
Kaopectate children's susp0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-3.9Chemaxon
pKa (Strongest Acidic)8.24Chemaxon
pKa (Strongest Basic)-4.7Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area147.59 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity10.01 m3·mol-1Chemaxon
Polarizability9.46 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at August 29, 2007 14:49 / Updated at September 28, 2021 21:54