Showing BioInteractions for Imipenem (DB01598)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Penicillin-binding protein 1A inhibitor | ||
| 1 | Penicillin-binding protein 1A inhibitors | Cefacetrile, Cefazolin, Cefmetazole, Cefonicid, Cefoperazone, Cefoxitin, Cefpiramide, Cefradine, Ceftazidime, Ceftibuten, Ceftizoxime, Doripenem, Ertapenem, Latamoxef |
| 2 | Penicillin-binding protein 1A antagonists | Doripenem |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Penicillin-binding protein 1B inhibitor | ||
| 1 | Penicillin-binding protein 1B inhibitors | Cefacetrile, Cefazolin, Cefmetazole, Cefonicid, Cefoperazone, Cefoxitin, Cefpiramide, Cefroxadine, Ceftazidime, Ceftibuten, Ceftizoxime, Doripenem, Ertapenem, Latamoxef |
| 2 | Penicillin-binding protein 1B antagonists | Cephaloglycin, Doripenem |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Penicillin-binding protein 2 inhibitor | ||
| 1 | Penicillin-binding protein 2 inhibitors | Amdinocillin, Cefazolin, Cefepime, Cefonicid, Cefoperazone, Ceftazidime, Ceftibuten, Ceftolozane, Doripenem, Ertapenem, Mezlocillin |
| 2 | Penicillin-binding protein 2 antagonists | Doripenem |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Penicillin-binding protein 3 inhibitor | ||
| 1 | Penicillin-binding protein 3 inhibitors | Aztreonam, Cefotaxime, Latamoxef |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Dipeptidase 1 substrate | ||
| 1 | Dipeptidase 1 inhibitors | Cilastatin |
| 2 | Dipeptidase 1 substrates | Doripenem |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Beta-lactamase SHV-1 substrate | ||
| 1 | Beta-lactamase SHV-1 inhibitors | Avibactam, Relebactam, Tazobactam |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Beta-lactamase TEM substrate | ||
| 1 | Beta-lactamase TEM inhibitors | Avibactam, Relebactam, Vaborbactam |
| 2 | Beta-lactamase TEM substrates | Benzylpenicillin |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Beta-lactamase CTX-M substrate | ||
| 1 | Beta-lactamase CTX-M inhibitors | Avibactam, Relebactam, Vaborbactam |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Imipenem is a Beta-lactamase (KPC-2) substrate | ||
| 1 | Beta-lactamase (KPC-2) inhibitors | Relebactam, Vaborbactam |