DrugBank: D-tartaric acid (DB01694)

targets (13)

Identification

Name

D-tartaric acid

Accession Number

DB01694 (EXPT03007)

Type

small molecule

Groups

experimental

Description

Not Available

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

(-)-Tartaric acid
(2S,3S)-Tartaric acid
(S,S)-Tartaric acid
(S,S)-Tartrate
D-Tartrate
D-threaric acid
Levotartaric Acid

Salts

Not Available

Brand names

Not Available

Brand mixtures

Not Available

Categories

Not Available

CAS number

147-71-7

Weight

Average: 150.0868
Monoisotopic: 150.016437924

Chemical Formula

C₄H₆O₆

InChI Key

InChIKey=FEWJPZIEWOKRBE-XIXRPRMCSA-N

InChI

InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2+

Plain Text

IUPAC Name

(2R,3S)-2,3-dihydroxybutanedioic acid

SMILES

O[C@@H]([C@@H](O)C(O)=O)C(O)=O

Plain Text

Mass Spec

Not Available

Taxonomy

Kingdom

Not Available

Classes

Not Available

Substructures

Not Available

Pharmacology

Indication

Not Available

Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Not Available

Pathways

Not Available

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage forms

Not Available

Prices

Not Available

Patents

Not Available

Properties

State

solid

Experimental Properties

Property	Value	Source
melting point	172.5 °C	PhysProp
water solubility	1E+006 mg/L (at 25 °C)	YALKOWSKY,SH & DANNENFELSER,RM (1992)

Predicted Properties

Property	Value	Source
water solubility	1.61e+02 g/l	ALOGPS
logP	-1.3	ALOGPS
logP	-1.8	ChemAxon
logS	0.03	ALOGPS
pKa (strongest acidic)	2.72	ChemAxon
pKa (strongest basic)	-4.3	ChemAxon
physiological charge	-2	ChemAxon
hydrogen acceptor count	6	ChemAxon
hydrogen donor count	4	ChemAxon
polar surface area	115.06	ChemAxon
rotatable bond count	3	ChemAxon
refractivity	26.21	ChemAxon
polarizability	11.69	ChemAxon

References

Synthesis Reference

Not Available

General Reference

Not Available

External Links

Resource	Link
KEGG Compound	C02107
PubChem Compound	447315
PubChem Substance	46508249
ChemSpider	852
ChEBI	15672
ChEMBL	15672
HET	TAR
Wikipedia	http://en.wikipedia.org/wiki/Tartaric_acid

ATC Codes

Not Available

AHFS Codes

Not Available

PDB Entries

1RQW

FDA label

Not Available

MSDS

Not Available

Interactions

Drug Interactions

Not Available

Food Interactions

Not Available

Targets
1. 2,3-diketo-L-gulonate reductase Pharmacological action: unknown Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate Organism class: bacterial UniProt ID: P37672 Gene: dlgD Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 2. Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Pharmacological action: unknown Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity:stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group Organism class: human UniProt ID: Q9P2W7 Gene: B3GAT1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 3. Triggering receptor expressed on myeloid cells 1 Pharmacological action: unknown Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock Organism class: human UniProt ID: Q9NP99 Gene: TREM1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 4. Probable ATP-dependent RNA helicase DDX6 Pharmacological action: unknown In the process of mRNA degradation, may play a role in mRNA decapping Organism class: human UniProt ID: P26196 Gene: DDX6 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 5. Cytochrome P450 Pharmacological action: unknown Organism class: bacterial UniProt ID: Q746J6 Gene: TT_P0059 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 6. Hypoxia-inducible factor 1 alpha inhibitor Pharmacological action: unknown Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases Organism class: human UniProt ID: Q9NWT6 Gene: HIF1AN Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 7. D-3-phosphoglycerate dehydrogenase Pharmacological action: unknown 3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH Organism class: bacterial UniProt ID: P0A544 Gene: serA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 8. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Pharmacological action: unknown Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Organism class: bacterial UniProt ID: O25927 Gene: lpxA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 9. V-type proton ATPase subunit C 1 Pharmacological action: unknown Organism class: human UniProt ID: P21283 Gene: ATP6V1C1 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 10. DTDP-4-dehydrorhamnose 3,5-epimerase Pharmacological action: unknown dTDP-4-dehydro-6-deoxy-D-glucose = dTDP-4- dehydro-6-deoxy-L-mannose Organism class: bacterial UniProt ID: Q9HU21 Gene: rmlC Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 11. Hypothetical protein VC0232 Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9KVB4 Gene: VC_0232 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 12. Phosphonoacetate hydrolase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q51782 Gene: phnA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 13. Hypothetical protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q97NR6 Gene: SP_1951 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report

Targets

1. 2,3-diketo-L-gulonate reductase

Pharmacological action: unknown

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate

Organism class: bacterial
UniProt ID: P37672 Link_out

Gene: dlgD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

Pharmacological action: unknown

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity:stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group

Organism class: human
UniProt ID: Q9P2W7 Link_out

Gene: B3GAT1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

3. Triggering receptor expressed on myeloid cells 1

Pharmacological action: unknown

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock

Organism class: human
UniProt ID: Q9NP99 Link_out

Gene: TREM1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. Probable ATP-dependent RNA helicase DDX6

Pharmacological action: unknown

In the process of mRNA degradation, may play a role in mRNA decapping

Organism class: human
UniProt ID: P26196 Link_out

Gene: DDX6
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

5. Cytochrome P450

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q746J6 Link_out

Gene: TT_P0059
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

6. Hypoxia-inducible factor 1 alpha inhibitor

Pharmacological action: unknown

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases

Organism class: human
UniProt ID: Q9NWT6 Link_out

Gene: HIF1AN
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

7. D-3-phosphoglycerate dehydrogenase

Pharmacological action: unknown

3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH

Organism class: bacterial
UniProt ID: P0A544 Link_out

Gene: serA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

8. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Pharmacological action: unknown

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)

Organism class: bacterial
UniProt ID: O25927 Link_out

Gene: lpxA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

9. V-type proton ATPase subunit C 1

Pharmacological action: unknown
Organism class: human
UniProt ID: P21283 Link_out

Gene: ATP6V1C1
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

10. DTDP-4-dehydrorhamnose 3,5-epimerase

Pharmacological action: unknown

dTDP-4-dehydro-6-deoxy-D-glucose = dTDP-4- dehydro-6-deoxy-L-mannose

Organism class: bacterial
UniProt ID: Q9HU21 Link_out

Gene: rmlC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

11. Hypothetical protein VC0232

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9KVB4 Link_out

Gene: VC_0232
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

12. Phosphonoacetate hydrolase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q51782 Link_out

Gene: phnA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

13. Hypothetical protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q97NR6 Link_out

Gene: SP_1951
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

Comments

Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:20