Rutin

Identification

Summary

Rutin is a flavonoid found in over-the-counter vitamin supplements.

Generic Name
Rutin
DrugBank Accession Number
DB01698
Background

A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility.

Type
Small Molecule
Groups
Approved, Experimental, Investigational
Structure
Weight
Average: 610.5175
Monoisotopic: 610.153384912
Chemical Formula
C27H30O16
Synonyms
  • 3-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 3-Rhamnoglucosylquercetin
  • 3-Rutinosyl quercetin
  • Phytomelin
  • Quercetin 3-rutinoside
  • Quercetin-3-rutinoside
  • Rutin
  • Rutoside
  • Rutosido
  • Rutosidum
  • Sophorin
  • Vitamin P
External IDs
  • C.I. 75730
  • NSC-9220

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
For therapyAnemia••• •••••••••
For therapyAnemia••• •••••••••
For therapyGeneral surgery••• •••••••••
For therapyPregnancy••• •••••••••
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UCarbonyl reductase [NADPH] 1Not AvailableHumans
UAldo-keto reductase family 1 member C3Not AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Rutin.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Rutin.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Rutin.
AripiprazoleThe metabolism of Aripiprazole can be decreased when combined with Rutin.
Aripiprazole lauroxilThe metabolism of Aripiprazole lauroxil can be decreased when combined with Rutin.
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Rutoside trihydrateRF4N03853G250249-75-3NLLBWFFSGHKUSY-JPRRWYCFSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
NAT-CRutin (50 mg) + Ascorbic acid (421.053 mg) + Calcium ascorbate dihydrate (412.372 mg) + Citrus bioflavonoids (50 mg) + Hesperidin (50 mg) + Malpighia emarginata extract (12.5 mg) + Rosa canina fruit (62.5 mg) + Sodium ascorbate (353.535 mg)Tablet, film coatedบริษัท เมก้า ไลฟ์ไซแอ็นซ์ จำกัด (มหาชน)2009-08-06Not applicableThailand flag
NAT-C 1000Rutin (50 mg) + Ascorbic acid (421.053 mg) + Calcium ascorbate (412.372 mg) + Citrus bioflavonoids (50 mg) + Hesperidin (50 mg) + Malpighia emarginata extract (12.5 mg) + Rosa canina fruit (62.5 mg) + Sodium ascorbate (353.535 mg)Tablet, film coatedบริษัท เมก้า ไลฟ์ไซแอ็นซ์ จำกัด (มหาชน)2019-04-18Not applicableThailand flag
Phlogenzym - FilmtablettenRutoside trihydrate (100 mg) + Bromelains (250 FIP units) + Trypsin (1440 FIP units)Tablet, film coatedOralMucos Pharma Gmb H & Co.Kg1998-10-28Not applicableAustria flag
Rose Hips 500plus Nu LifeRutin (50 mg) + Ascorbic acid (500 mg) + Citrus bioflavonoids (100 mg) + Hesperidin (100 mg)TabletOralNu Life Nutrition Ltd.1972-12-312005-03-15Canada flag
Rutozym - FilmtablettenRutoside trihydrate (100 mg) + Bromelains (450 FIP units) + Trypsin (1440 FIP units)Tablet, film coatedOralMucos Pharma Gmb H & Co.Kg2001-08-02Not applicableAustria flag

Categories

ATC Codes
C05CA51 — Rutoside, combinationsC05CA01 — Rutoside
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as flavonoid-3-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C3-position.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Flavonoids
Sub Class
Flavonoid glycosides
Direct Parent
Flavonoid-3-O-glycosides
Alternative Parents
3'-hydroxyflavonoids / 4'-hydroxyflavonoids / 5-hydroxyflavonoids / 7-hydroxyflavonoids / Flavones / O-glycosyl compounds / Chromones / Disaccharides / Catechols / Pyranones and derivatives
show 12 more
Substituents
1-benzopyran / 1-hydroxy-2-unsubstituted benzenoid / 1-hydroxy-4-unsubstituted benzenoid / 3'-hydroxyflavonoid / 4'-hydroxyflavonoid / 5-hydroxyflavonoid / 7-hydroxyflavonoid / Acetal / Alcohol / Aromatic heteropolycyclic compound
show 25 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
rutinoside, disaccharide derivative, tetrahydroxyflavone, quercetin O-glucoside (CHEBI:28527) / flavonols (C05625)
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
5G06TVY3R7
CAS number
153-18-4
InChI Key
IKGXIBQEEMLURG-NVPNHPEKSA-N
InChI
InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-/m0/s1
IUPAC Name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-one
SMILES
C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OC3=C(OC4=CC(O)=CC(O)=C4C3=O)C3=CC(O)=C(O)C=C3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

References

Synthesis Reference

Yukio Suzuki, Kei Suzuki, Masaru Yoneyama, Toshio Miyake, "4.sup.G -alpha-D-glucopyranosyl rutin, and its preparation and uses." U.S. Patent US5171573, issued October, 1979.

US5171573
General References
Not Available
Human Metabolome Database
HMDB0003249
KEGG Compound
C05625
PubChem Compound
5280805
PubChem Substance
46508549
ChemSpider
4444362
RxNav
9500
ChEBI
28527
ChEMBL
CHEMBL226335
ZINC
ZINC000004096846
PharmGKB
PA451291
PDBe Ligand
RUT
Wikipedia
Rutin
PDB Entries
1ry8 / 8c3q
MSDS
Download (72 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentAnemia, Pernicious / Megaloblastic anemia1
Not AvailableCompletedNot AvailableGlaucoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • V Sab Medical Labs Inc.
Dosage Forms
FormRouteStrength
CapsuleOral
TabletOral
Tablet, film coated
Tablet, film coatedOral
Tablet, delayed releaseOral
Capsule
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)125 °CPhysProp
water solubility125 mg/LMERCK (1989)
Predicted Properties
PropertyValueSource
Water Solubility3.54 mg/mLALOGPS
logP0.15ALOGPS
logP-0.87Chemaxon
logS-2.2ALOGPS
pKa (Strongest Acidic)6.37Chemaxon
pKa (Strongest Basic)-3.7Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count16Chemaxon
Hydrogen Donor Count10Chemaxon
Polar Surface Area265.52 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity140.15 m3·mol-1Chemaxon
Polarizability57.08 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.8041
Blood Brain Barrier-0.8542
Caco-2 permeable-0.9172
P-glycoprotein substrateSubstrate0.6901
P-glycoprotein inhibitor INon-inhibitor0.8759
P-glycoprotein inhibitor IINon-inhibitor0.8546
Renal organic cation transporterNon-inhibitor0.8977
CYP450 2C9 substrateNon-substrate0.7639
CYP450 2D6 substrateNon-substrate0.8962
CYP450 3A4 substrateNon-substrate0.5374
CYP450 1A2 substrateNon-inhibitor0.8673
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9545
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9249
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6787
Ames testNon AMES toxic0.5118
CarcinogenicityNon-carcinogens0.9608
BiodegradationNot ready biodegradable0.8339
Rat acute toxicity2.4984 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9814
hERG inhibition (predictor II)Non-inhibitor0.7469
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-052p-7581190000-d9593c696e6c6e2454ed
MS/MS Spectrum - Quattro_QQQ 10V, PositiveLC-MS/MSsplash10-03di-0000009000-a6b8403579a83c69506b
MS/MS Spectrum - Quattro_QQQ 25V, PositiveLC-MS/MSsplash10-03di-0002009000-ffacf122369038644c02
MS/MS Spectrum - Quattro_QQQ 40V, PositiveLC-MS/MSsplash10-0w29-5009015000-f74826ba5205775d12b8
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 5V, PositiveLC-MS/MSsplash10-03di-0003109000-85542c3510756d258e11
LC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , PositiveLC-MS/MSsplash10-0ik9-0008109000-f0d08078ad4b887cce0d
LC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , NegativeLC-MS/MSsplash10-0a4i-0000009000-f07697affe03ff93dad3
LC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , PositiveLC-MS/MSsplash10-0udi-0009000000-1b117e308c1ab00aa4a7
MS/MS Spectrum - ESI-TOF , NegativeLC-MS/MSsplash10-0a4i-0000009000-270308e3f77a0404dea8
MS/MS Spectrum - ESI-TOF 10V, NegativeLC-MS/MSsplash10-0a4i-0010009000-f94b0edacf4c3bc9c9e3
MS/MS Spectrum - ESI-TOF 40V, NegativeLC-MS/MSsplash10-0udi-0049001000-8327d9d15b0d22a0c968
MS/MS Spectrum - ESI-TOF , NegativeLC-MS/MSsplash10-0a4i-0000009000-270308e3f77a0404dea8
MS/MS Spectrum - ESI-TOF 10V, NegativeLC-MS/MSsplash10-0a4i-0010009000-f94b0edacf4c3bc9c9e3
MS/MS Spectrum - ESI-TOF 40V, NegativeLC-MS/MSsplash10-0udi-0049001000-8327d9d15b0d22a0c968
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSsplash10-0udi-0009100000-dfc0a2b72193a5072dde
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0a4i-0000009000-dd163a2a17fe559c3482
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0a4i-0000009000-7b408d31853f85c12619
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0a4i-0001009000-3a559cbd175dfd7bafc9
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0udi-0009005000-a090fd87b44b66b9f0c0
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0udi-0009000000-8454cc7afaccaa2be7ac
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-188aab377f9eecd8695d
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-8027e3471abd62fb2791
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-5ec73bcca3286a80f7c6
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-ea0de1e1b0699fa8401d
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-a8dce85d4d31db22026b
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-2376e0472b15420aba8f
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0a4i-0000009002-ae4978beb8ec8448d966
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0a4i-0000009002-c7f26693cd399d8d8302
LC-MS/MS Spectrum - LC-ESI-TOF , negativeLC-MS/MSsplash10-0udi-0049001000-8327d9d15b0d22a0c968
MS/MS Spectrum - , negativeLC-MS/MSsplash10-0zfr-0118009000-bbfe9a963d6e073b31aa
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-03di-0004409000-c9657d18e3d38620d7c0
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009300000-ff0584aa53087380857c
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-d8e250bcd87201ff91d8
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-cb501d427defe87144e1
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-382e4e2175615ff65850
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0wmi-0009506000-98ca7f7c8f3072af4481
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0wmi-0009506000-717207d912e0da3f0ec1
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-c8c1fc25375ea6875243
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0019000000-92c9eb453c2b2bb6047f
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009300000-d5183f81716bf8deb8ee
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-a790b0597ebf4b0f07f0
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-707a876bedc341afce24
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0029300000-a6374dbb49e6d5bf31ae
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0uxr-0029400000-47da08e5dc97e23c44bf
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0549220000-79a7fad4164d8e1f5d57
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0179020000-363093d6c7189d2ca5b7
LC-MS/MS Spectrum - LC-ESI-ITTOF , positiveLC-MS/MSsplash10-0udi-0009000000-1b117e308c1ab00aa4a7
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009100000-580b79451bd64dfcab03
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009100000-8bbfe0044ae8800be3c8
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009300000-caaa9f9ce4563b800c19
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009300000-e598235294a3f55f962b
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009200000-f9d3912b5e9bcc4aa4a6
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009200000-031817287b54fa353ecd
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009200000-2bf263364eccf1425f98
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009200000-6c976c714e8f9a7558af
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0001319000-2f06049e21fa11589fb7
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0001319000-4c4d3b0053f951060192
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009200000-e1502b5888ff7ad6d318
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009100000-6d0bd005bd7b223c7cf5
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009100000-3b95244720444d2f3d13
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009200000-25001dbcf8355eaf8bd0
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0006-0016951000-1a24ae1c026ee49c0b0b
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0006-0017961000-90d27c883fd31667a17c
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001r-1010105009-fe5059a016b66f6e6508
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-1010105009-aca266334d999e83075f
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0ika-0080109107-1d617056ba5c260c56b0
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udm-0230119117-ddbbc348bb71199c4af9
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udi-0009100000-c5715285ddf62f77c126
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udi-0009000000-4a64a91365b6888199d3
MS/MS Spectrum - , positiveLC-MS/MSsplash10-001i-0001009000-be5fbd1a3dc6eb89cea6
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0i00-0204924000-4566a608b760010d0a4a
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-0601159000-92c9f3ccc79221fa2da5
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0j4j-0819735000-48737f8093c460fe38e2
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4l-2112393000-baa44d599b2c603c6d23
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-01ot-2545952000-7c3fed41b16a1234d9d0
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0kmi-1692011000-b64918fdc816b0dcd80a
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-228.272102
predicted
DarkChem Lite v0.1.0
[M-H]-214.9401103
predicted
DarkChem Standard v0.1.0
[M-H]-233.031302
predicted
DarkChem Lite v0.1.0
[M-H]-228.78703
predicted
DeepCCS 1.0 (2019)
[M+H]+228.355802
predicted
DarkChem Lite v0.1.0
[M+H]+227.7752149
predicted
DarkChem Standard v0.1.0
[M+H]+234.857302
predicted
DarkChem Lite v0.1.0
[M+H]+230.89938
predicted
DeepCCS 1.0 (2019)
[M+Na]+229.211902
predicted
DarkChem Lite v0.1.0
[M+Na]+247.7863025
predicted
DarkChem Standard v0.1.0
[M+Na]+234.122302
predicted
DarkChem Lite v0.1.0
[M+Na]+236.91771
predicted
DeepCCS 1.0 (2019)

Targets

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insights and accelerate drug research.
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Prostaglandin-e2 9-reductase activity
Specific Function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. ...
Gene Name
CBR1
Uniprot ID
P16152
Uniprot Name
Carbonyl reductase [NADPH] 1
Molecular Weight
30374.73 Da
References
  1. Carlquist M, Frejd T, Gorwa-Grauslund MF: Flavonoids as inhibitors of human carbonyl reductase 1. Chem Biol Interact. 2008 Jul 30;174(2):98-108. doi: 10.1016/j.cbi.2008.05.021. Epub 2008 May 23. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Specific Function
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2....
Gene Name
AKR1C3
Uniprot ID
P42330
Uniprot Name
Aldo-keto reductase family 1 member C3
Molecular Weight
36852.89 Da
References
  1. Skarydova L, Zivna L, Xiong G, Maser E, Wsol V: AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44. doi: 10.1016/j.cbi.2008.10.015. Epub 2008 Oct 19. [Article]
  2. Barski OA, Tipparaju SM, Bhatnagar A: The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug Metab Rev. 2008;40(4):553-624. doi: 10.1080/03602530802431439. [Article]

Enzymes

Details
1. Cytochrome P450 3A4
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Yu CP, Wu PP, Hou YC, Lin SP, Tsai SY, Chen CT, Chao PD: Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4. J Agric Food Chem. 2011 May 11;59(9):4644-8. doi: 10.1021/jf104786t. Epub 2011 Apr 5. [Article]

Drug created at June 13, 2005 13:24 / Updated at May 06, 2021 01:09