Banner
targets (36) enzymes (1)
for drugs
Identification
Name S-Adenosyl-L-Homocysteine
Accession Number DB01752 (EXPT02842)
Type small molecule
Groups experimental
Description

5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. [PubChem]
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names Not Available
Brand mixtures Not Available
Categories Not Available
CAS number 979-92-0
Weight Average: 384.411
Monoisotopic: 384.12158847
Chemical Formula C14H20N6O5S
InChI Key InChIKey=ZJUKTBDSGOFHSH-SRMDEQNCSA-N
InChI
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7-,9-,10+,13+/m0/s1
Plain Text
IUPAC Name
(2S)-2-amino-4-({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid
SMILES
N[C@@H](CCSC[C@@H]1O[C@H]([C@H](O)[C@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 4.08e+00 g/l ALOGPS
logP -2.4 ALOGPS
logP -4 ChemAxon
logS -2 ALOGPS
pKa (strongest acidic) 1.81 ChemAxon
pKa (strongest basic) 9.5 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 10 ChemAxon
hydrogen donor count 5 ChemAxon
polar surface area 182.63 ChemAxon
rotatable bond count 7 ChemAxon
refractivity 92.72 ChemAxon
polarizability 38.21 ChemAxon
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
KEGG Compound C00021 Link_out
PubChem Compound 46936206 Link_out
PubChem Substance 46508993 Link_out
ChemSpider 188 Link_out
ChEBI 16680 Link_out
ChEMBL 16680 Link_out
HET SAH Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Protein methyltransferase hemK

Pharmacological action: unknown

Methylates the translation termination release factor RF1 on 'Gln-235' and RF2 on 'Gln-252'

Organism class: bacterial
UniProt ID: P0ACC1 Link_out
Gene: hemK
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. Cap-specific mRNA

Pharmacological action: unknown

Methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-o-methylpurine cap. Also act as a regulatory subunit of polymerase that creates the 3' poly(A) tail of mRNA's; the regulatory subunit binds to poly(A) but has no catalytic activity

Organism class: viral
UniProt ID: P07617 Link_out
Gene: PAPS
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

3. Cobalt-precorrin-4 C(11)-methyltransferase

Pharmacological action: unknown

Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5

Organism class: bacterial
UniProt ID: O87696 Link_out
Gene: cbiF
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. Protein-L-isoaspartate(D-aspartate) O-methyltransferase

Pharmacological action: unknown

Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl- terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein

Organism class: human
UniProt ID: P22061 Link_out
Gene: PCMT1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

5. Genome polyprotein

Pharmacological action: unknown

The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function. NS5 may play a role in the viral RNA replication. The NS2B/NS3 protease complex processes the viral polyprotein

Organism class: viral
UniProt ID: P12823 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

6. Phenylethanolamine N-methyltransferase

Pharmacological action: unknown

Converts noradrenaline to adrenaline

Organism class: human
UniProt ID: P11086 Link_out
Gene: PNMT Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

7. Cyclopropane-fatty-acyl-phospholipid synthase 2

Pharmacological action: unknown

Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge. Mycolic acids, which represent the major constituent of mycobacterial cell wall complex, act as substrates

Organism class: bacterial
UniProt ID: P0A5P0 Link_out
Gene: cmaA2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

8. Modification methylase RsrI

Pharmacological action: unknown

This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-? on both strands, and protects the DNA from cleavage by the RsrI endonuclease

Organism class: bacterial
UniProt ID: P14751 Link_out
Gene: rsrIM
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. HemK protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WYV8 Link_out
Gene: TM_0488
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

10. Protein arginine N-methyltransferase 3

Pharmacological action: unknown
Organism class: human
UniProt ID: O60678 Link_out
Gene: PRMT3
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

11. Histamine N-methyltransferase

Pharmacological action: unknown

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine

Organism class: human
UniProt ID: P50135 Link_out
Gene: HNMT
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

12. S-adenosyl-L-methionine-dependent methyltransferase mraW

Pharmacological action: unknown

Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity)

Organism class: bacterial
UniProt ID: Q9WZX6 Link_out
Gene: rsmH
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

13. rRNA adenine N-6-methyltransferase

Pharmacological action: unknown

This protein produces a dimethylation of the adenine residue at position 2058 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics

Organism class: bacterial
UniProt ID: P13956 Link_out
Gene: ermC'
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

14. tRNA

Pharmacological action: unknown

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)

Organism class: human
UniProt ID: O14717 Link_out
Gene: TRDMT1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

15. Glycine N-methyltransferase

Pharmacological action: unknown

Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine

Organism class: human
UniProt ID: Q14749 Link_out
Gene: GNMT Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

16. Probable tRNA/rRNA methyltransferase HI0766

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P44868 Link_out
Gene: trmL
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

17. Modification methylase PvuII

Pharmacological action: unknown

This methylase recognizes the double-stranded sequence CAGCTG, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the PvuII endonuclease

Organism class: bacterial
UniProt ID: P11409 Link_out
Gene: pvuIIM
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

18. DNA adenine methylase

Pharmacological action: unknown

This methylase recognizes the double-stranded sequence GATC, causes specific methylation on A-2 on both strands

Organism class: viral
UniProt ID: P04392 Link_out
Gene: DAM
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

19. Mycolic acid synthase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7D9R5 Link_out
Gene: pcaA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

20. Protein arginine N-methyltransferase 1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q99873 Link_out
Gene: PRMT1
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

21. Siroheme synthase

Pharmacological action: unknown

Multifunctional enzyme that catalyze the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme

Organism class: bacterial
UniProt ID: P25924 Link_out
Gene: cysG
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

22. Modification methylase HhaI

Pharmacological action: unknown

This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease

Organism class: bacterial
UniProt ID: P05102 Link_out
Gene: hhaIM
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

23. Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7

Pharmacological action: unknown

Histone methyltransferase. Methylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation

Organism class: human
UniProt ID: Q8WTS6 Link_out
Gene: SETD7
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

24. tRNA

Pharmacological action: unknown

Specifically methylates guanosine-37 in various tRNAs (By similarity)

Organism class: bacterial
UniProt ID: P43912 Link_out
Gene: trmD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

25. METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q79FX6 Link_out
Gene: mmaA2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

26. Diphthine synthase

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9H2P9 Link_out
Gene: DPH5
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

27. RdmB

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q54527 Link_out
Gene: rdmB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

28. tRNA

Pharmacological action: unknown

Specifically methylates guanosine-37 in various tRNAs (By similarity)

Organism class: bacterial
UniProt ID: P0A876 Link_out
Gene: trmD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

29. Uroporphyrinogen-III C-methyltransferase

Pharmacological action: unknown

Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin

Organism class: bacterial
UniProt ID: P21631 Link_out
Gene: cobA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

30. Hypothetical protein TTHA0667

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q5SKH6 Link_out
Gene: TTHA0667
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

31. Chemotaxis protein methyltransferase

Pharmacological action: unknown

Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP

Organism class: bacterial
UniProt ID: P07801 Link_out
Gene: cheR
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

32. Modification methylase TaqI

Pharmacological action: unknown

This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the TaqI endonuclease

Organism class: bacterial
UniProt ID: P14385 Link_out
Gene: taqIM
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

33. Protein-L-isoaspartate O-methyltransferase

Pharmacological action: unknown

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

Organism class: bacterial
UniProt ID: Q56308 Link_out
Gene: pcm
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

34. Catechol O-methyltransferase domain-containing protein 1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q86VU5 Link_out
Gene: COMTD1
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

35. Carminomycin 4-O-methyltransferase

Pharmacological action: unknown

Catalyzes the conversion of carminomycin to daunorubicin

Organism class: bacterial
UniProt ID: Q06528 Link_out
Gene: dnrK
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

36. Guanidinoacetate N-methyltransferase

Pharmacological action: unknown
Organism class: human
UniProt ID: Q14353 Link_out
Gene: GAMT Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed
Enzymes

1. Histamine N-methyltransferase

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine

UniProt ID: P50135 Link_out
Gene: HNMT
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out
Comments
Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:20