DrugBank: Beta-D-Glucose (DB02379)

targets (92) enzymes (1)

Identification

Name

Beta-D-Glucose

Accession Number

DB02379 (EXPT00455, EXPT00685, EXPT01603)

Type

small molecule

Groups

experimental

Description

A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. [PubChem]

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

Not Available

Salts

Not Available

Brand names

Not Available

Brand mixtures

Not Available

Categories

Sweetening Agents

CAS number

50-99-7

Weight

Average: 180.1559
Monoisotopic: 180.063388116

Chemical Formula

C₆H₁₂O₆

InChI Key

InChIKey=WQZGKKKJIJFFOK-QYESYBIKSA-N

InChI

InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m0/s1

Plain Text

IUPAC Name

(2S,3S,4R,5R,6S)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol

SMILES

OC[C@@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@H]1O

Plain Text

Mass Spec

Not Available

Taxonomy

Kingdom

Not Available

Classes

Not Available

Substructures

Not Available

Pharmacology

Indication

Not Available

Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Not Available

Pathways

Not Available

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage forms

Not Available

Prices

Not Available

Patents

Not Available

Properties

State

solid

Experimental Properties

Property	Value	Source
melting point	83 °C	PhysProp
water solubility	1.2E+006 mg/L (at 30 °C)	MULLIN,JW (1972)
logP	-3.24	SANGSTER (1994)
logS	0.74	ADME Research, USCD
pKa	12.9 (at 0 °C)	KORTUM,G ET AL (1961)

Predicted Properties

Property	Value	Source
water solubility	7.82e+02 g/l	ALOGPS
logP	-2.6	ALOGPS
logP	-2.9	ChemAxon
logS	0.64	ALOGPS
pKa (strongest acidic)	11.3	ChemAxon
pKa (strongest basic)	-3	ChemAxon
physiological charge	0	ChemAxon
hydrogen acceptor count	6	ChemAxon
hydrogen donor count	5	ChemAxon
polar surface area	110.38	ChemAxon
rotatable bond count	1	ChemAxon
refractivity	35.92	ChemAxon
polarizability	16.3	ChemAxon

References

Synthesis Reference

Not Available

General Reference

Not Available

External Links

Resource	Link
KEGG Drug	D00009
KEGG Compound	C00221
PubChem Compound	6992084
PubChem Substance	46505414
ChemSpider	201
BindingDB	34103
ChEBI	15903
ChEMBL	15903
HET	BGC
Drug Product Database	37915

ATC Codes

Not Available

AHFS Codes

Not Available

PDB Entries

1PIG

FDA label

Not Available

MSDS

Not Available

Interactions

Drug Interactions

Not Available

Food Interactions

Not Available

Targets
1. Glycogen phosphorylase, muscle form Pharmacological action: unknown Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties Organism class: human UniProt ID: P11217 Gene: PYGM Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 2. Xylose isomerase Pharmacological action: unknown Involved in D-xylose catabolism Organism class: bacterial UniProt ID: P15587 Gene: xylA Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 3. Glucokinase Pharmacological action: unknown Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage Organism class: human UniProt ID: P35557 Gene: GCK Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 4. Ferrichrome-iron receptor Pharmacological action: unknown This receptor binds the ferrichrome-iron ligand. It interacts with the tonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin Organism class: bacterial UniProt ID: P06971 Gene: fhuA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 5. Aldose 1-epimerase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9ZB17 Gene: galM Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 6. POSSIBLE CELLULASE CELA1 Pharmacological action: unknown Organism class: bacterial UniProt ID: Q79G13 Gene: celA1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 7. Glucokinase Pharmacological action: unknown Not highly important in E.coli as glucose is transported into the cell by the pts system already as glucose 6-phosphate Organism class: bacterial UniProt ID: P0A6V8 Gene: glk Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 8. Amylase Pharmacological action: unknown Organism class: bacterial UniProt ID: O82839 Protein Sequence: FASTA Gene Sequence: FASTA 9. Fucose-binding lectin PA-IIL Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9HYN5 Gene: lecB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 10. BH0236 protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9KG76 Gene: BH0236 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 11. Laminarinase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9WXN1 Gene: TM_0024 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 12. Endo-1,4-beta-xylanase A Pharmacological action: unknown Endoxylanase that degrades arabinoxylan and glucuronoxylan to xylobiose and xylotriose (in vitro) Organism class: bacterial UniProt ID: Q8GJ44 Gene: xynA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 13. Cellulase B Pharmacological action: unknown Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans Organism class: bacterial UniProt ID: O07653 Gene: celB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 14. Endoglucanase C Pharmacological action: unknown The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes:(1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) Beta-1,4- glucosidases which hydrolyze the cellobiose and other short cello- oligosaccharides to glucose Organism class: bacterial UniProt ID: P14090 Gene: cenC Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 15. Endoglucanase SS precursor Pharmacological action: unknown This enzyme catalyzes the endohydrolysis of 1,4-beta- glucosidic linkages in cellulose, lichenin and cereal beta-D- glucans Organism class: bacterial UniProt ID: P0C2S5 Gene: celS Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 16. D-galactose-binding periplasmic protein precursor Pharmacological action: unknown This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor Organism class: bacterial UniProt ID: P0AEE5 Gene: mglB Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 17. Glycosyltransferase 6 domain-containing protein 1 Pharmacological action: unknown Organism class: human UniProt ID: Q7Z4J2 Gene: GLT6D1 SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 18. Glucosamine-6-phosphate isomerase Pharmacological action: unknown D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3) Organism class: human UniProt ID: P46926 Gene: GNPDA1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 19. Beta-amylase Pharmacological action: unknown Hydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains Organism class: bacterial UniProt ID: P36924 Gene: spoII Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 20. ADP-ribose pyrophosphatase, mitochondrial Pharmacological action: unknown Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'- phosphate Organism class: human UniProt ID: Q9BW91 Gene: NUDT9 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 21. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Pharmacological action: unknown Organism class: human UniProt ID: O60264 Gene: SMARCA5 SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 22. Cyclomaltodextrin glucanotransferase Pharmacological action: unknown Degrades starch to alpha-, beta-, and gamma- cyclodextrins, as well as linear sugars Organism class: bacterial UniProt ID: P26827 Gene: amyA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 23. Enterotoxin type B Pharmacological action: unknown Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death Organism class: bacterial UniProt ID: P01552 Gene: entB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 24. Salivary alpha-amylase Pharmacological action: unknown Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides Organism class: human UniProt ID: P04745 Gene: AMY1A Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 25. Maltodextrin phosphorylase Pharmacological action: unknown Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties Organism class: bacterial UniProt ID: P00490 Gene: malP Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 26. Shiga toxin B-chain Pharmacological action: unknown The B-chain is responsible for binding the holotoxin to specific receptors on the target cell surface Organism class: viral UniProt ID: P69178 Gene: stxB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 27. Neurocan core protein Pharmacological action: unknown Organism class: human UniProt ID: O14594 Gene: NCAN SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 28. Beta-glucanase Pharmacological action: unknown Hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans containing 1,3- and 1,4-bonds Organism class: bacterial UniProt ID: P23904 Protein Sequence: FASTA Gene Sequence: FASTA References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 29. Quinoprotein glucose dehydrogenase-B Pharmacological action: unknown Oxidizes glucose to gluconolactone Organism class: bacterial UniProt ID: P13650 Gene: gdhB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 30. Alpha-amylase Pharmacological action: unknown Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides Organism class: bacterial UniProt ID: P00692 Protein Sequence: FASTA Gene Sequence: FASTA References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 31. DNA Pharmacological action: unknown DNA is the molecule of heredity, as it is responsible for the genetic propagation of most inherited traits. It is a polynucleic acid that carries genetic information on cell growth, division, and function. DNA consists of two long strands of nucleotides twisted into a double helix and held together by hydrogen bonds. The sequence of nucleotides determines hereditary characteristics. Each strand serves as the template for subsequent DNA replication and as a template for mRNA production, leading to protein synthesis via ribosomes. Gene Sequence: FASTA References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 32. Alpha-amylase Pharmacological action: unknown Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides Organism class: bacterial UniProt ID: P29957 Gene: amy Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 33. Cellulase B precursor Pharmacological action: unknown Organism class: bacterial UniProt ID: Q54331 Gene: celB Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 34. Chondroitinase B Pharmacological action: unknown Cleaves the glycosaminoglycan, dermatan sulfate Organism class: bacterial UniProt ID: Q46079 Gene: cslB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 35. Aspartate ammonia-lyase Pharmacological action: unknown L-aspartate = fumarate + NH(3) Organism class: bacterial UniProt ID: P0AC38 Gene: aspA Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 36. Endoglucanase 5A Pharmacological action: unknown Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans Organism class: bacterial UniProt ID: O85465 Gene: cel5A Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 37. Lactase-like protein Pharmacological action: unknown Organism class: human UniProt ID: Q6UWM7 Gene: LCTL Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 38. Amylosucrase Pharmacological action: unknown Catalyzes the synthesis of alpha-glucan from sucrose. Catalyzes, in addition, sucrose hydrolysis, maltose and maltotriose synthesis by successive transfers of the glucosyl moiety of sucrose onto the released glucose, and finally turanose and trehalulose synthesis, these two sucrose isomers being obtained by glucosyl transfer onto fructose Organism class: bacterial UniProt ID: Q9ZEU2 Gene: ams Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 39. Pancreatic alpha-amylase Pharmacological action: unknown Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides Organism class: human UniProt ID: P04746 Gene: AMY2A Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 40. YtnJ Pharmacological action: unknown Organism class: bacterial UniProt ID: O34974 Gene: moxC Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 41. Endoglucanase E1 Pharmacological action: unknown Has a very high specific activity on carboxymethylcellulose Organism class: bacterial UniProt ID: P54583 Gene: Acel_0614 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 42. D-galactose-binding periplasmic protein Pharmacological action: unknown This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor Organism class: bacterial UniProt ID: P23905 Gene: mglB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 43. Ecotin Pharmacological action: unknown General inhibitor of pancreatic serine proteases:inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity Organism class: bacterial UniProt ID: P23827 Gene: eco Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 44. A/G-specific adenine glycosylase Pharmacological action: unknown Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past go lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine Organism class: bacterial UniProt ID: P17802 Gene: mutY Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 45. Keratin-associated protein 5-2 Pharmacological action: unknown Organism class: human UniProt ID: Q701N4 Gene: KRTAP5-2 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 46. Sialoadhesin Pharmacological action: unknown Organism class: human UniProt ID: Q9BZZ2 Gene: SIGLEC1 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 47. Neopullulanase Pharmacological action: unknown Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form maltotriose Organism class: bacterial UniProt ID: P38940 Gene: nplT Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 48. Endo-1,4-beta-xylanase A Pharmacological action: unknown Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans Organism class: bacterial UniProt ID: Q60037 Gene: xynA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 49. Maltoporin Pharmacological action: unknown Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages Organism class: bacterial UniProt ID: P26466 Gene: lamB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 50. Hexokinase Pharmacological action: unknown ATP + D-hexose = ADP + D-hexose 6-phosphate Organism class: parasitic UniProt ID: Q26609 Protein Sequence: FASTA Gene Sequence: FASTA 51. Neopullulanase 1 Pharmacological action: unknown Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Also hydrolyzes cyclodextrins Organism class: bacterial UniProt ID: Q60053 Gene: tvaI Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 52. Endo-1,4-beta-xylanase Pharmacological action: unknown Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans Organism class: bacterial UniProt ID: P40943 Protein Sequence: FASTA Gene Sequence: FASTA 53. Cyclomaltodextrin glucanotransferase Pharmacological action: unknown Cyclizes part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond Organism class: bacterial UniProt ID: P43379 Gene: cgt Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 54. Maltoporin Pharmacological action: unknown Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic residues serves to guide and select the sugars for transport through the channel. Also acts as a receptor for several bacteriophages including lambda Organism class: bacterial UniProt ID: P02943 Gene: lamB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 55. Myoglobin Pharmacological action: unknown Organism class: human UniProt ID: P02144 Gene: MB SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 56. Galectin-2 Pharmacological action: unknown This protein binds beta-galactoside. Its physiological function is not yet known Organism class: human UniProt ID: P05162 Gene: LGALS2 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 57. Prostaglandin G/H synthase 1 Pharmacological action: unknown May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells Organism class: human UniProt ID: P23219 Gene: PTGS1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 58. Hexokinase-1 Pharmacological action: unknown ATP + D-hexose = ADP + D-hexose 6-phosphate Organism class: human UniProt ID: P19367 Gene: HK1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 59. Maltooligosyltrehalose trehalohydrolase, putative Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9RX51 Gene: treZ Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 60. Alpha-amylase Pharmacological action: unknown Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides Organism class: bacterial UniProt ID: P00691 Gene: amyE Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 61. Inorganic polyphosphate/ATP-glucomannokinase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q7WT42 Gene: ppgmk Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 62. Exoglucanase/xylanase [Includes: Exoglucanase Pharmacological action: unknown The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes:(1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) Beta-1,4- glucosidases which hydrolyze the cellobiose and other short cello- oligosaccharides to glucose Organism class: bacterial UniProt ID: P07986 Gene: cex Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 63. Acetoin(diacetyl) reductase Pharmacological action: unknown Catalyzes the reversible reduction of acetoin to 2,3- butanediol in the presence of NADH Organism class: bacterial UniProt ID: Q48436 Gene: budC Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 64. Cyclomaltodextrin glucanotransferase Pharmacological action: unknown Cyclizes part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond Organism class: bacterial UniProt ID: P05618 Gene: cgt Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 65. Coat protein VP1 Pharmacological action: unknown Organism class: viral UniProt ID: P49302 Protein Sequence: FASTA Gene Sequence: FASTA 66. Endoglucanase G Pharmacological action: unknown The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes:(1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) Beta-1,4- glucosidases which hydrolyze the cellobiose and other short cello- oligosaccharides to glucose Organism class: bacterial UniProt ID: P37700 Gene: celCCG Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 67. Hydrolase Pharmacological action: unknown Organism class: bacterial UniProt ID: Q7SI98 Protein Sequence: FASTA 68. Galectin-7 Pharmacological action: unknown Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release Organism class: human UniProt ID: P47929 Gene: LGALS7 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 69. Cholera enterotoxin subunit B Pharmacological action: unknown The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself Organism class: bacterial UniProt ID: P01556 Gene: ctxB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 70. Keratin-associated protein 5-3 Pharmacological action: unknown Organism class: human UniProt ID: Q6L8H2 Gene: KRTAP5-3 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 71. Dimethyl sulfoxide reductase Pharmacological action: unknown Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds Organism class: bacterial UniProt ID: Q57366 Gene: dmsA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 72. Endoglucanase C307 Pharmacological action: unknown This enzyme catalyzes the endohydrolysis of 1,4-beta- glucosidic linkages in cellulose, lichenin and cereal beta-D- glucans Organism class: bacterial UniProt ID: P23340 Gene: celC307 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 73. Alpha-amylase 2B Pharmacological action: unknown Organism class: human UniProt ID: P19961 Gene: AMY2B SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 74. Cyclomaltodextrin glucanotransferase Pharmacological action: unknown Cyclizes part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond Organism class: bacterial UniProt ID: P30920 Protein Sequence: FASTA Gene Sequence: FASTA References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 75. Endo-1,4-beta glucanase EngF Pharmacological action: unknown Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans Organism class: bacterial UniProt ID: P94622 Gene: engF Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 76. Neopullulanase 2 Pharmacological action: unknown Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form maltotriose Organism class: bacterial UniProt ID: Q08751 Gene: tvaII Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 77. Endoglucanase E-4 Pharmacological action: unknown Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans Organism class: bacterial UniProt ID: P26221 Gene: celD Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 78. Botulinum neurotoxin type B Pharmacological action: unknown Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-\|-Phe-77' bond of synaptobrevin-2 Organism class: bacterial UniProt ID: P10844 Gene: botB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 79. Slt-IIvB Pharmacological action: unknown Organism class: bacterial UniProt ID: Q47644 Gene: stxB2e Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 80. Tetanus toxin Pharmacological action: unknown Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe- 77' bond of synaptobrevin-2 Organism class: bacterial UniProt ID: P04958 Gene: tetX Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 81. Xylose isomerase Pharmacological action: unknown Involved in D-xylose catabolism Organism class: bacterial UniProt ID: P24300 Gene: xylA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 82. Glucan 1,4-alpha-maltohexaosidase Pharmacological action: unknown Hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends Organism class: bacterial UniProt ID: P19571 Protein Sequence: FASTA Gene Sequence: FASTA References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 83. Glucan 1,4-alpha-maltotetraohydrolase Pharmacological action: unknown Hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends Organism class: bacterial UniProt ID: P13507 Gene: amyP Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 84. Endoglucanase F Pharmacological action: unknown Probable endoglucanase involved in the degradation of cellulose or related beta-glucans Organism class: bacterial UniProt ID: P37698 Gene: celCCF Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 85. Glucose--fructose oxidoreductase Pharmacological action: unknown D-glucose + D-fructose = D-gluconolactone + D- glucitol Organism class: bacterial UniProt ID: Q07982 Gene: gfo Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 86. Bifunctional tail protein Pharmacological action: unknown Non-covalently bound to the neck of the phage capsid and essential for phage adsorption to the bacterial host. It displays endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O- glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide Organism class: viral UniProt ID: P12528 Gene: 9 Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 87. Glycogen phosphorylase, liver form Pharmacological action: unknown Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties Organism class: human UniProt ID: P06737 Gene: PYGL Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 88. Pulmonary surfactant-associated protein D Pharmacological action: unknown Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties Organism class: human UniProt ID: P35247 Gene: SFTPD Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 89. Interferon beta Pharmacological action: unknown Has antiviral, antibacterial and anticancer activities Organism class: human UniProt ID: P01574 Gene: IFNB1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 90. Maltose-binding periplasmic protein precursor Pharmacological action: unknown Involved in the high-affinity maltose membrane transport system malEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides Organism class: bacterial UniProt ID: P0AEX9 Gene: malE Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 91. Enoyl-[acyl-carrier-protein] reductase [NADH] Pharmacological action: unknown Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH Organism class: bacterial UniProt ID: P0AEK4 Gene: fabI Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 92. Endoglucanase A Pharmacological action: unknown This enzyme catalyzes the endohydrolysis of 1,4-beta- glucosidic linkages in cellulose, lichenin and cereal beta-D- glucans Organism class: bacterial UniProt ID: P0C2S2 Gene: celA Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Targets

1. Glycogen phosphorylase, muscle form

Pharmacological action: unknown

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

Organism class: human
UniProt ID: P11217 Link_out

Gene: PYGM Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

2. Xylose isomerase

Pharmacological action: unknown

Involved in D-xylose catabolism

Organism class: bacterial
UniProt ID: P15587 Link_out

Gene: xylA
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

3. Glucokinase

Pharmacological action: unknown

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage

Organism class: human
UniProt ID: P35557 Link_out

Gene: GCK

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. Ferrichrome-iron receptor

Pharmacological action: unknown

This receptor binds the ferrichrome-iron ligand. It interacts with the tonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin

Organism class: bacterial
UniProt ID: P06971 Link_out

Gene: fhuA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

5. Aldose 1-epimerase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9ZB17 Link_out

Gene: galM
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

6. POSSIBLE CELLULASE CELA1

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q79G13 Link_out

Gene: celA1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

7. Glucokinase

Pharmacological action: unknown

Not highly important in E.coli as glucose is transported into the cell by the pts system already as glucose 6-phosphate

Organism class: bacterial
UniProt ID: P0A6V8 Link_out

Gene: glk
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

8. Amylase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O82839 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

9. Fucose-binding lectin PA-IIL

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9HYN5 Link_out

Gene: lecB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

10. BH0236 protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9KG76 Link_out

Gene: BH0236
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

11. Laminarinase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WXN1 Link_out

Gene: TM_0024
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

12. Endo-1,4-beta-xylanase A

Pharmacological action: unknown

Endoxylanase that degrades arabinoxylan and glucuronoxylan to xylobiose and xylotriose (in vitro)

Organism class: bacterial
UniProt ID: Q8GJ44 Link_out

Gene: xynA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

13. Cellulase B

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans

Organism class: bacterial
UniProt ID: O07653 Link_out

Gene: celB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

14. Endoglucanase C

Pharmacological action: unknown

The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes:(1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) Beta-1,4- glucosidases which hydrolyze the cellobiose and other short cello- oligosaccharides to glucose

Organism class: bacterial
UniProt ID: P14090 Link_out

Gene: cenC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

15. Endoglucanase SS precursor

Pharmacological action: unknown

This enzyme catalyzes the endohydrolysis of 1,4-beta- glucosidic linkages in cellulose, lichenin and cereal beta-D- glucans

Organism class: bacterial
UniProt ID: P0C2S5 Link_out

Gene: celS
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

16. D-galactose-binding periplasmic protein precursor

Pharmacological action: unknown

This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor

Organism class: bacterial
UniProt ID: P0AEE5 Link_out

Gene: mglB
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

17. Glycosyltransferase 6 domain-containing protein 1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q7Z4J2 Link_out

Gene: GLT6D1
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

18. Glucosamine-6-phosphate isomerase

Pharmacological action: unknown

D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)

Organism class: human
UniProt ID: P46926 Link_out

Gene: GNPDA1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

19. Beta-amylase

Pharmacological action: unknown

Hydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains

Organism class: bacterial
UniProt ID: P36924 Link_out

Gene: spoII
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

20. ADP-ribose pyrophosphatase, mitochondrial

Pharmacological action: unknown

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'- phosphate

Organism class: human
UniProt ID: Q9BW91 Link_out

Gene: NUDT9 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Pharmacological action: unknown
Organism class: human
UniProt ID: O60264 Link_out

Gene: SMARCA5
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

22. Cyclomaltodextrin glucanotransferase

Pharmacological action: unknown

Degrades starch to alpha-, beta-, and gamma- cyclodextrins, as well as linear sugars

Organism class: bacterial
UniProt ID: P26827 Link_out

Gene: amyA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

23. Enterotoxin type B

Pharmacological action: unknown

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death

Organism class: bacterial
UniProt ID: P01552 Link_out

Gene: entB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

24. Salivary alpha-amylase

Pharmacological action: unknown

Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

Organism class: human
UniProt ID: P04745 Link_out

Gene: AMY1A Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

25. Maltodextrin phosphorylase

Pharmacological action: unknown

Organism class: bacterial
UniProt ID: P00490 Link_out

Gene: malP
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

26. Shiga toxin B-chain

Pharmacological action: unknown

The B-chain is responsible for binding the holotoxin to specific receptors on the target cell surface

Organism class: viral
UniProt ID: P69178 Link_out

Gene: stxB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

27. Neurocan core protein

Pharmacological action: unknown
Organism class: human
UniProt ID: O14594 Link_out

Gene: NCAN
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

28. Beta-glucanase

Pharmacological action: unknown

Hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans containing 1,3- and 1,4-bonds

Organism class: bacterial
UniProt ID: P23904 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

29. Quinoprotein glucose dehydrogenase-B

Pharmacological action: unknown

Oxidizes glucose to gluconolactone

Organism class: bacterial
UniProt ID: P13650 Link_out

Gene: gdhB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

30. Alpha-amylase

Pharmacological action: unknown

Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

Organism class: bacterial
UniProt ID: P00692 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

31. DNA

Pharmacological action: unknown

DNA is the molecule of heredity, as it is responsible for the genetic propagation of most inherited traits. It is a polynucleic acid that carries genetic information on cell growth, division, and function. DNA consists of two long strands of nucleotides twisted into a double helix and held together by hydrogen bonds. The sequence of nucleotides determines hereditary characteristics. Each strand serves as the template for subsequent DNA replication and as a template for mRNA production, leading to protein synthesis via ribosomes.

Gene Sequence: FASTA

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

32. Alpha-amylase

Pharmacological action: unknown

Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

Organism class: bacterial
UniProt ID: P29957 Link_out

Gene: amy
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

33. Cellulase B precursor

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q54331 Link_out

Gene: celB
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

34. Chondroitinase B

Pharmacological action: unknown

Cleaves the glycosaminoglycan, dermatan sulfate

Organism class: bacterial
UniProt ID: Q46079 Link_out

Gene: cslB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

35. Aspartate ammonia-lyase

Pharmacological action: unknown

L-aspartate = fumarate + NH(3)

Organism class: bacterial
UniProt ID: P0AC38 Link_out

Gene: aspA
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

36. Endoglucanase 5A

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans

Organism class: bacterial
UniProt ID: O85465 Link_out

Gene: cel5A
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

37. Lactase-like protein

Pharmacological action: unknown
Organism class: human
UniProt ID: Q6UWM7 Link_out

Gene: LCTL Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

38. Amylosucrase

Pharmacological action: unknown

Catalyzes the synthesis of alpha-glucan from sucrose. Catalyzes, in addition, sucrose hydrolysis, maltose and maltotriose synthesis by successive transfers of the glucosyl moiety of sucrose onto the released glucose, and finally turanose and trehalulose synthesis, these two sucrose isomers being obtained by glucosyl transfer onto fructose

Organism class: bacterial
UniProt ID: Q9ZEU2 Link_out

Gene: ams
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

39. Pancreatic alpha-amylase

Pharmacological action: unknown

Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

Organism class: human
UniProt ID: P04746 Link_out

Gene: AMY2A
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

40. YtnJ

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O34974 Link_out

Gene: moxC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

41. Endoglucanase E1

Pharmacological action: unknown

Has a very high specific activity on carboxymethylcellulose

Organism class: bacterial
UniProt ID: P54583 Link_out

Gene: Acel_0614
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

42. D-galactose-binding periplasmic protein

Pharmacological action: unknown

This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor

Organism class: bacterial
UniProt ID: P23905 Link_out

Gene: mglB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

43. Ecotin

Pharmacological action: unknown

General inhibitor of pancreatic serine proteases:inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity

Organism class: bacterial
UniProt ID: P23827 Link_out

Gene: eco
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

44. A/G-specific adenine glycosylase

Pharmacological action: unknown

Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past go lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine

Organism class: bacterial
UniProt ID: P17802 Link_out

Gene: mutY
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

45. Keratin-associated protein 5-2

Pharmacological action: unknown
Organism class: human
UniProt ID: Q701N4 Link_out

Gene: KRTAP5-2
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

46. Sialoadhesin

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9BZZ2 Link_out

Gene: SIGLEC1
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

47. Neopullulanase

Pharmacological action: unknown

Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form maltotriose

Organism class: bacterial
UniProt ID: P38940 Link_out

Gene: nplT
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

48. Endo-1,4-beta-xylanase A

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans

Organism class: bacterial
UniProt ID: Q60037 Link_out

Gene: xynA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

49. Maltoporin

Pharmacological action: unknown

Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages

Organism class: bacterial
UniProt ID: P26466 Link_out

Gene: lamB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

50. Hexokinase

Pharmacological action: unknown

ATP + D-hexose = ADP + D-hexose 6-phosphate

Organism class: parasitic
UniProt ID: Q26609 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

51. Neopullulanase 1

Pharmacological action: unknown

Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Also hydrolyzes cyclodextrins

Organism class: bacterial
UniProt ID: Q60053 Link_out

Gene: tvaI
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

52. Endo-1,4-beta-xylanase

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans

Organism class: bacterial
UniProt ID: P40943 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

53. Cyclomaltodextrin glucanotransferase

Pharmacological action: unknown

Cyclizes part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond

Organism class: bacterial
UniProt ID: P43379 Link_out

Gene: cgt
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

54. Maltoporin

Pharmacological action: unknown

Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic residues serves to guide and select the sugars for transport through the channel. Also acts as a receptor for several bacteriophages including lambda

Organism class: bacterial
UniProt ID: P02943 Link_out

Gene: lamB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

55. Myoglobin

Pharmacological action: unknown
Organism class: human
UniProt ID: P02144 Link_out

Gene: MB
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

56. Galectin-2

Pharmacological action: unknown

This protein binds beta-galactoside. Its physiological function is not yet known

Organism class: human
UniProt ID: P05162 Link_out

Gene: LGALS2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

57. Prostaglandin G/H synthase 1

Pharmacological action: unknown

May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells

Organism class: human
UniProt ID: P23219 Link_out

Gene: PTGS1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

58. Hexokinase-1

Pharmacological action: unknown

ATP + D-hexose = ADP + D-hexose 6-phosphate

Organism class: human
UniProt ID: P19367 Link_out

Gene: HK1

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

59. Maltooligosyltrehalose trehalohydrolase, putative

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9RX51 Link_out

Gene: treZ
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

60. Alpha-amylase

Pharmacological action: unknown

Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

Organism class: bacterial
UniProt ID: P00691 Link_out

Gene: amyE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

61. Inorganic polyphosphate/ATP-glucomannokinase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7WT42 Link_out

Gene: ppgmk
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

62. Exoglucanase/xylanase [Includes: Exoglucanase

Pharmacological action: unknown

Organism class: bacterial
UniProt ID: P07986 Link_out

Gene: cex
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

63. Acetoin(diacetyl) reductase

Pharmacological action: unknown

Catalyzes the reversible reduction of acetoin to 2,3- butanediol in the presence of NADH

Organism class: bacterial
UniProt ID: Q48436 Link_out

Gene: budC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

64. Cyclomaltodextrin glucanotransferase

Pharmacological action: unknown

Cyclizes part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond

Organism class: bacterial
UniProt ID: P05618 Link_out

Gene: cgt
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

65. Coat protein VP1

Pharmacological action: unknown
Organism class: viral
UniProt ID: P49302 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

66. Endoglucanase G

Pharmacological action: unknown

Organism class: bacterial
UniProt ID: P37700 Link_out

Gene: celCCG
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

67. Hydrolase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7SI98 Link_out

Protein Sequence: FASTA

68. Galectin-7

Pharmacological action: unknown

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release

Organism class: human
UniProt ID: P47929 Link_out

Gene: LGALS7 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

69. Cholera enterotoxin subunit B

Pharmacological action: unknown

The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself

Organism class: bacterial
UniProt ID: P01556 Link_out

Gene: ctxB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

70. Keratin-associated protein 5-3

Pharmacological action: unknown
Organism class: human
UniProt ID: Q6L8H2 Link_out

Gene: KRTAP5-3
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

71. Dimethyl sulfoxide reductase

Pharmacological action: unknown

Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds

Organism class: bacterial
UniProt ID: Q57366 Link_out

Gene: dmsA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

72. Endoglucanase C307

Pharmacological action: unknown

This enzyme catalyzes the endohydrolysis of 1,4-beta- glucosidic linkages in cellulose, lichenin and cereal beta-D- glucans

Organism class: bacterial
UniProt ID: P23340 Link_out

Gene: celC307
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

73. Alpha-amylase 2B

Pharmacological action: unknown
Organism class: human
UniProt ID: P19961 Link_out

Gene: AMY2B
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

74. Cyclomaltodextrin glucanotransferase

Pharmacological action: unknown

Cyclizes part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond

Organism class: bacterial
UniProt ID: P30920 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

75. Endo-1,4-beta glucanase EngF

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans

Organism class: bacterial
UniProt ID: P94622 Link_out

Gene: engF
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

76. Neopullulanase 2

Pharmacological action: unknown

Organism class: bacterial
UniProt ID: Q08751 Link_out

Gene: tvaII
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

77. Endoglucanase E-4

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans

Organism class: bacterial
UniProt ID: P26221 Link_out

Gene: celD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

78. Botulinum neurotoxin type B

Pharmacological action: unknown

Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2

Organism class: bacterial
UniProt ID: P10844 Link_out

Gene: botB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

79. Slt-IIvB

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q47644 Link_out

Gene: stxB2e
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

80. Tetanus toxin

Pharmacological action: unknown

Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe- 77' bond of synaptobrevin-2

Organism class: bacterial
UniProt ID: P04958 Link_out

Gene: tetX
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

81. Xylose isomerase

Pharmacological action: unknown

Involved in D-xylose catabolism

Organism class: bacterial
UniProt ID: P24300 Link_out

Gene: xylA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

82. Glucan 1,4-alpha-maltohexaosidase

Pharmacological action: unknown

Hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends

Organism class: bacterial
UniProt ID: P19571 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

83. Glucan 1,4-alpha-maltotetraohydrolase

Pharmacological action: unknown

Hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends

Organism class: bacterial
UniProt ID: P13507 Link_out

Gene: amyP
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

84. Endoglucanase F

Pharmacological action: unknown

Probable endoglucanase involved in the degradation of cellulose or related beta-glucans

Organism class: bacterial
UniProt ID: P37698 Link_out

Gene: celCCF
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

85. Glucose--fructose oxidoreductase

Pharmacological action: unknown

D-glucose + D-fructose = D-gluconolactone + D- glucitol

Organism class: bacterial
UniProt ID: Q07982 Link_out

Gene: gfo
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

86. Bifunctional tail protein

Pharmacological action: unknown

Non-covalently bound to the neck of the phage capsid and essential for phage adsorption to the bacterial host. It displays endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O- glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide

Organism class: viral
UniProt ID: P12528 Link_out

Gene: 9
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

87. Glycogen phosphorylase, liver form

Pharmacological action: unknown

Organism class: human
UniProt ID: P06737 Link_out

Gene: PYGL Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

88. Pulmonary surfactant-associated protein D

Pharmacological action: unknown

Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties

Organism class: human
UniProt ID: P35247 Link_out

Gene: SFTPD Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

89. Interferon beta

Pharmacological action: unknown

Has antiviral, antibacterial and anticancer activities

Organism class: human
UniProt ID: P01574 Link_out

Gene: IFNB1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

90. Maltose-binding periplasmic protein precursor

Pharmacological action: unknown

Involved in the high-affinity maltose membrane transport system malEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides

Organism class: bacterial
UniProt ID: P0AEX9 Link_out

Gene: malE
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

91. Enoyl-[acyl-carrier-protein] reductase [NADH]

Pharmacological action: unknown

Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH

Organism class: bacterial
UniProt ID: P0AEK4 Link_out

Gene: fabI
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

92. Endoglucanase A

Pharmacological action: unknown

This enzyme catalyzes the endohydrolysis of 1,4-beta- glucosidic linkages in cellulose, lichenin and cereal beta-D- glucans

Organism class: bacterial
UniProt ID: P0C2S2 Link_out

Gene: celA
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Enzymes
1. Pancreatic alpha-amylase Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides UniProt ID: P04746 Gene: AMY2A Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report

Comments

Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:21