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transporters (1)
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Identification
Name D-Proline
Accession Number DB02853 (EXPT01259)
Type small molecule
Groups experimental
Description

A non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons. [PubChem]
Structure Thumb
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Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names Not Available
Brand mixtures Not Available
Categories Not Available
CAS number 344-25-2
Weight Average: 115.1305
Monoisotopic: 115.063328537
Chemical Formula C5H9NO2
InChI Key InChIKey=ONIBWKKTOPOVIA-BYPYZUCNSA-N
InChI
InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
Plain Text
IUPAC Name
(2S)-pyrrolidine-2-carboxylic acid
SMILES
OC(=O)[C@@H]1CCCN1
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 3.65e+02 g/l ALOGPS
logP -2.7 ALOGPS
logP -2.6 ChemAxon
logS 0.5 ALOGPS
pKa (strongest acidic) 1.94 ChemAxon
pKa (strongest basic) 11.33 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 3 ChemAxon
hydrogen donor count 2 ChemAxon
polar surface area 49.33 ChemAxon
rotatable bond count 1 ChemAxon
refractivity 28.06 ChemAxon
polarizability 11.47 ChemAxon
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
KEGG Compound C00763 Link_out
PubChem Compound 145742 Link_out
PubChem Substance 46504839 Link_out
ChEBI 16313 Link_out
ChEMBL 16313 Link_out
IUPHAR 3314 Link_out
Guide to Pharmacology 3314 Link_out
HET DPR Link_out
Drug Product Database 285528 Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Transporters

1. Proton-coupled amino acid transporter 1

Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid

UniProt ID: Q7Z2H8 Link_out
Gene: SLC36A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Metzner L, Kalbitz J, Brandsch M: Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1. J Pharmacol Exp Ther. 2004 Apr;309(1):28-35. Epub 2004 Jan 12. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on March 01, 2013 18:38