Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
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Identification
- Generic Name
- Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
- DrugBank Accession Number
- DB02872
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 686.434
Monoisotopic: 684.09468089 - Chemical Formula
- C31H34Br2N4O4
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UE3 ubiquitin-protein ligase Mdm2 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
- Kingdom
- Organic compounds
- Super Class
- Phenylpropanoids and polyketides
- Class
- Stilbenes
- Sub Class
- Not Available
- Direct Parent
- Stilbenes
- Alternative Parents
- Piperazine carboxamides / Anisoles / Methoxybenzenes / Phenoxy compounds / Alkyl aryl ethers / Bromobenzenes / N-alkylpiperazines / Aryl bromides / Imidazolines / Ureas show 11 more
- Substituents
- 1,2-aminoalcohol / 1,4-diazinane / 2-imidazoline / Alcohol / Alkanolamine / Alkyl aryl ether / Amidine / Amine / Anisole / Aromatic heteromonocyclic compound show 33 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
- InChI Key
- PVRYEWOXWGDQHA-URLMMPGGSA-N
- InChI
- InChI=1S/C31H34Br2N4O4/c1-3-41-27-20-25(40-2)12-13-26(27)30-34-28(21-4-8-23(32)9-5-21)29(22-6-10-24(33)11-7-22)37(30)31(39)36-16-14-35(15-17-36)18-19-38/h4-13,20,28-29,38H,3,14-19H2,1-2H3/t28-,29+/m0/s1
- IUPAC Name
- 2-{4-[(4S,5R)-4,5-bis(4-bromophenyl)-2-(2-ethoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-1-yl}ethan-1-ol
- SMILES
- [H][C@]1(N=C(N(C(=O)N2CCN(CCO)CC2)[C@]1([H])C1=CC=C(Br)C=C1)C1=C(OCC)C=C(OC)C=C1)C1=CC=C(Br)C=C1
References
- General References
- Not Available
- External Links
- PubChem Compound
- 5288631
- PubChem Substance
- 46507913
- ChemSpider
- 4450754
- BindingDB
- 50392531
- ChEMBL
- CHEMBL407632
- ZINC
- ZINC000028467964
- PDBe Ligand
- IMZ
- PDB Entries
- 1rv1
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00547 mg/mL ALOGPS logP 5.06 ALOGPS logP 5.52 Chemaxon logS -5.1 ALOGPS pKa (Strongest Acidic) 15.59 Chemaxon pKa (Strongest Basic) 6.77 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 77.84 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 166.88 m3·mol-1 Chemaxon Polarizability 65.61 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9915 Blood Brain Barrier + 0.5935 Caco-2 permeable - 0.5361 P-glycoprotein substrate Substrate 0.8255 P-glycoprotein inhibitor I Non-inhibitor 0.5093 P-glycoprotein inhibitor II Inhibitor 0.6315 Renal organic cation transporter Inhibitor 0.5308 CYP450 2C9 substrate Non-substrate 0.7307 CYP450 2D6 substrate Non-substrate 0.8218 CYP450 3A4 substrate Substrate 0.5999 CYP450 1A2 substrate Non-inhibitor 0.7705 CYP450 2C9 inhibitor Non-inhibitor 0.659 CYP450 2D6 inhibitor Non-inhibitor 0.8227 CYP450 2C19 inhibitor Non-inhibitor 0.7251 CYP450 3A4 inhibitor Non-inhibitor 0.7628 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.5508 Ames test Non AMES toxic 0.6789 Carcinogenicity Non-carcinogens 0.7377 Biodegradation Not ready biodegradable 1.0 Rat acute toxicity 2.6041 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.6617 hERG inhibition (predictor II) Inhibitor 0.662
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 234.60994 predictedDeepCCS 1.0 (2019) [M+H]+ 236.82684 predictedDeepCCS 1.0 (2019) [M+Na]+ 242.60875 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsE3 ubiquitin-protein ligase Mdm2
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by bindi...
- Gene Name
- MDM2
- Uniprot ID
- Q00987
- Uniprot Name
- E3 ubiquitin-protein ligase Mdm2
- Molecular Weight
- 55232.39 Da
References
Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52