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Identification
NameSphingosine
Accession NumberDB03203  (EXPT02945)
TypeSmall Molecule
GroupsExperimental
DescriptionAn amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIINGZ37HRE42
CAS number123-78-4
WeightAverage: 299.4919
Monoisotopic: 299.282429433
Chemical FormulaC18H37NO2
InChI KeyInChIKey=WWUZIQQURGPMPG-BXDGKWANSA-N
InChI
InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14-/t17-,18+/m1/s1
IUPAC Name
(2R,3S,4Z)-2-aminooctadec-4-ene-1,3-diol
SMILES
[H][C@@](N)(CO)[C@@]([H])(O)\C=C/CCCCCCCCCCCCC
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as sphingolipids. These are lipids containing backbone of sphingoid bases (e.g. Sphinogsine, sphinganine) usually bound to a fatty acid derivative through N-acylation.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSphingolipids
Sub ClassNot Available
Direct ParentSphingolipids
Alternative Parents
Substituents
  • Sphingoid base
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Hydrocarbon derivative
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Amine
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Pharmacology
IndicationNot Available
PharmacodynamicsNot Available
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.995
Blood Brain Barrier+0.5839
Caco-2 permeable-0.573
P-glycoprotein substrateSubstrate0.5295
P-glycoprotein inhibitor INon-inhibitor0.9155
P-glycoprotein inhibitor IINon-inhibitor0.7564
Renal organic cation transporterNon-inhibitor0.8759
CYP450 2C9 substrateNon-substrate0.8247
CYP450 2D6 substrateNon-substrate0.706
CYP450 3A4 substrateNon-substrate0.7191
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9151
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7332
Ames testNon AMES toxic0.7957
CarcinogenicityNon-carcinogens0.7754
BiodegradationReady biodegradable0.748
Rat acute toxicity1.6142 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8822
hERG inhibition (predictor II)Non-inhibitor0.854
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point67 °CPhysProp
Predicted Properties
PropertyValueSource
Water Solubility0.0039 mg/mLALOGPS
logP5.15ALOGPS
logP4.57ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)14.12ChemAxon
pKa (Strongest Basic)9.23ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area66.48 Å2ChemAxon
Rotatable Bond Count15ChemAxon
Refractivity91.89 m3·mol-1ChemAxon
Polarizability39.36 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Dennis Liotta, Alfred H. Merrill, “Method of preparing sphingosine derivatives.” U.S. Patent US5110987, issued August, 1976.

US5110987
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AcetaminophenThe serum concentration of Sphingosine can be increased when it is combined with Acetaminophen.
AfatinibThe serum concentration of Sphingosine can be increased when it is combined with Afatinib.
AlbendazoleThe serum concentration of Sphingosine can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Sphingosine can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Sphingosine can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Sphingosine can be increased when it is combined with Alfentanil.
AmantadineThe serum concentration of Sphingosine can be increased when it is combined with Amantadine.
Aminohippuric acidThe serum concentration of Sphingosine can be increased when it is combined with Aminohippuric acid.
AmiodaroneThe serum concentration of Sphingosine can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Sphingosine can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Sphingosine can be increased when it is combined with Amlodipine.
AmprenavirThe serum concentration of Sphingosine can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Sphingosine can be increased when it is combined with Amsacrine.
AstemizoleThe serum concentration of Sphingosine can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Sphingosine can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Sphingosine can be increased when it is combined with Atenolol.
AtorvastatinThe serum concentration of Sphingosine can be increased when it is combined with Atorvastatin.
AzelastineThe serum concentration of Sphingosine can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Sphingosine can be increased when it is combined with Azithromycin.
BenzocaineThe serum concentration of Sphingosine can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Sphingosine can be increased when it is combined with Bepridil.
BiperidenThe serum concentration of Sphingosine can be increased when it is combined with Biperiden.
BosutinibThe serum concentration of Sphingosine can be increased when it is combined with Bosutinib.
BromocriptineThe serum concentration of Sphingosine can be increased when it is combined with Bromocriptine.
BuprenorphineThe serum concentration of Sphingosine can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Sphingosine can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Sphingosine can be increased when it is combined with Cabazitaxel.
CaffeineThe serum concentration of Sphingosine can be increased when it is combined with Caffeine.
CanagliflozinThe serum concentration of Sphingosine can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Sphingosine can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Sphingosine can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Sphingosine can be decreased when it is combined with Carbamazepine.
CarvedilolThe serum concentration of Sphingosine can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Sphingosine can be increased when it is combined with Caspofungin.
ChloroquineThe serum concentration of Sphingosine can be increased when it is combined with Chloroquine.
ChlorpromazineThe serum concentration of Sphingosine can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Sphingosine can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Sphingosine can be increased when it is combined with Chlorprothixene.
CholesterolThe serum concentration of Sphingosine can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Sphingosine can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Sphingosine can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Sphingosine can be decreased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Sphingosine can be increased when it is combined with Ciprofloxacin.
CitalopramThe serum concentration of Sphingosine can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Sphingosine can be increased when it is combined with Clarithromycin.
ClofazimineThe serum concentration of Sphingosine can be increased when it is combined with Clofazimine.
ClomipramineThe serum concentration of Sphingosine can be increased when it is combined with Clomipramine.
ClotrimazoleThe serum concentration of Sphingosine can be decreased when it is combined with Clotrimazole.
CobicistatThe serum concentration of Sphingosine can be increased when it is combined with Cobicistat.
ColchicineThe serum concentration of Sphingosine can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Sphingosine can be increased when it is combined with Colforsin.
CrizotinibThe serum concentration of Sphingosine can be increased when it is combined with Crizotinib.
CyclophosphamideThe serum concentration of Sphingosine can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Sphingosine can be decreased when it is combined with Cyclosporine.
DaclatasvirThe serum concentration of Sphingosine can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Sphingosine can be increased when it is combined with Dactinomycin.
DasatinibThe serum concentration of Sphingosine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Sphingosine can be decreased when it is combined with Daunorubicin.
DesipramineThe serum concentration of Sphingosine can be increased when it is combined with Desipramine.
DesloratadineThe serum concentration of Sphingosine can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Sphingosine can be decreased when it is combined with Dexamethasone.
DextromethorphanThe serum concentration of Sphingosine can be increased when it is combined with Dextromethorphan.
DiclofenacThe serum concentration of Sphingosine can be increased when it is combined with Diclofenac.
DigoxinThe serum concentration of Sphingosine can be decreased when it is combined with Digoxin.
DihydroergotamineThe serum concentration of Sphingosine can be increased when it is combined with Dihydroergotamine.
DiltiazemThe serum concentration of Sphingosine can be increased when it is combined with Diltiazem.
DipyridamoleThe serum concentration of Sphingosine can be increased when it is combined with Dipyridamole.
DoxazosinThe serum concentration of Sphingosine can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Sphingosine can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Sphingosine can be decreased when it is combined with Doxorubicin.
DronabinolThe serum concentration of Sphingosine can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Sphingosine can be increased when it is combined with Dronedarone.
ElbasvirThe serum concentration of Sphingosine can be increased when it is combined with Elbasvir.
EnalaprilThe serum concentration of Sphingosine can be increased when it is combined with Enalapril.
EnzalutamideThe serum concentration of Sphingosine can be increased when it is combined with Enzalutamide.
ErgonovineThe serum concentration of Sphingosine can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Sphingosine can be increased when it is combined with Ergotamine.
ErythromycinThe serum concentration of Sphingosine can be decreased when it is combined with Erythromycin.
EstramustineThe serum concentration of Sphingosine can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Sphingosine can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Sphingosine can be decreased when it is combined with Estrone.
EtoposideThe serum concentration of Sphingosine can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Sphingosine can be increased when it is combined with Etravirine.
FelodipineThe serum concentration of Sphingosine can be increased when it is combined with Felodipine.
FentanylThe serum concentration of Sphingosine can be increased when it is combined with Fentanyl.
FexofenadineThe serum concentration of Sphingosine can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Sphingosine can be increased when it is combined with Fidaxomicin.
FluconazoleThe serum concentration of Sphingosine can be increased when it is combined with Fluconazole.
FluoxetineThe serum concentration of Sphingosine can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Sphingosine can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Sphingosine can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Sphingosine can be increased when it is combined with Flurazepam.
FluvoxamineThe serum concentration of Sphingosine can be increased when it is combined with Fluvoxamine.
GefitinibThe serum concentration of Sphingosine can be increased when it is combined with Gefitinib.
GenisteinThe serum concentration of Sphingosine can be increased when it is combined with Genistein.
GlyburideThe serum concentration of Sphingosine can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Sphingosine can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Sphingosine can be increased when it is combined with Gramicidin D.
GrepafloxacinThe serum concentration of Sphingosine can be increased when it is combined with Grepafloxacin.
HaloperidolThe serum concentration of Sphingosine can be increased when it is combined with Haloperidol.
HydrocortisoneThe serum concentration of Sphingosine can be increased when it is combined with Hydrocortisone.
IdelalisibThe serum concentration of Sphingosine can be increased when it is combined with Idelalisib.
ImatinibThe serum concentration of Sphingosine can be increased when it is combined with Imatinib.
ImipramineThe serum concentration of Sphingosine can be increased when it is combined with Imipramine.
IndinavirThe serum concentration of Sphingosine can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Sphingosine can be increased when it is combined with Indomethacin.
IsavuconazoniumThe serum concentration of Sphingosine can be increased when it is combined with Isavuconazonium.
ItraconazoleThe serum concentration of Sphingosine can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Sphingosine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Sphingosine can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Sphingosine can be increased when it is combined with Ketamine.
KetoconazoleThe serum concentration of Sphingosine can be increased when it is combined with Ketoconazole.
LansoprazoleThe serum concentration of Sphingosine can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Sphingosine can be increased when it is combined with Lapatinib.
LevofloxacinThe serum concentration of Sphingosine can be increased when it is combined with Levofloxacin.
LevothyroxineThe serum concentration of Sphingosine can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Sphingosine can be increased when it is combined with Lidocaine.
LiothyronineThe serum concentration of Sphingosine can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Sphingosine can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Sphingosine can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Sphingosine can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Sphingosine can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Sphingosine can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Sphingosine can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Sphingosine can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Sphingosine can be increased when it is combined with Lovastatin.
LumacaftorThe serum concentration of Sphingosine can be decreased when it is combined with Lumacaftor.
MaprotilineThe serum concentration of Sphingosine can be increased when it is combined with Maprotiline.
MebendazoleThe serum concentration of Sphingosine can be increased when it is combined with Mebendazole.
MefloquineThe serum concentration of Sphingosine can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Sphingosine can be increased when it is combined with Megestrol acetate.
MeprobamateThe serum concentration of Sphingosine can be increased when it is combined with Meprobamate.
MethadoneThe serum concentration of Sphingosine can be increased when it is combined with Methadone.
MetoprololThe serum concentration of Sphingosine can be increased when it is combined with Metoprolol.
MibefradilThe serum concentration of Sphingosine can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Sphingosine can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Sphingosine can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Sphingosine can be decreased when it is combined with Mifepristone.
MitomycinThe serum concentration of Sphingosine can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Sphingosine can be decreased when it is combined with Mitoxantrone.
MorphineThe serum concentration of Sphingosine can be increased when it is combined with Morphine.
NaltrexoneThe serum concentration of Sphingosine can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Sphingosine can be increased when it is combined with Naringenin.
NefazodoneThe serum concentration of Sphingosine can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Sphingosine can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Sphingosine can be increased when it is combined with Neostigmine.
NicardipineThe serum concentration of Sphingosine can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Sphingosine can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Sphingosine can be increased when it is combined with Nilotinib.
NisoldipineThe serum concentration of Sphingosine can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Sphingosine can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Sphingosine can be increased when it is combined with Nitrendipine.
NorethisteroneThe serum concentration of Sphingosine can be decreased when it is combined with Norethisterone.
OmeprazoleThe serum concentration of Sphingosine can be increased when it is combined with Omeprazole.
P-NitrophenolThe serum concentration of Sphingosine can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Sphingosine can be increased when it is combined with Paclitaxel.
Palmitic AcidThe serum concentration of Sphingosine can be increased when it is combined with Palmitic Acid.
PantoprazoleThe serum concentration of Sphingosine can be increased when it is combined with Pantoprazole.
ParoxetineThe serum concentration of Sphingosine can be increased when it is combined with Paroxetine.
PerindoprilThe serum concentration of Sphingosine can be increased when it is combined with Perindopril.
PhenobarbitalThe serum concentration of Sphingosine can be decreased when it is combined with Phenobarbital.
PimozideThe serum concentration of Sphingosine can be increased when it is combined with Pimozide.
Platelet Activating FactorThe serum concentration of Sphingosine can be decreased when it is combined with Platelet Activating Factor.
PonatinibThe serum concentration of Sphingosine can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Sphingosine can be increased when it is combined with Posaconazole.
PravastatinThe serum concentration of Sphingosine can be increased when it is combined with Pravastatin.
PrazosinThe serum concentration of Sphingosine can be increased when it is combined with Prazosin.
PrednisoneThe serum concentration of Sphingosine can be increased when it is combined with Prednisone.
ProbenecidThe serum concentration of Sphingosine can be increased when it is combined with Probenecid.
ProgesteroneThe serum concentration of Sphingosine can be decreased when it is combined with Progesterone.
PromethazineThe serum concentration of Sphingosine can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Sphingosine can be increased when it is combined with Propafenone.
PropranololThe serum concentration of Sphingosine can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Sphingosine can be increased when it is combined with Protriptyline.
QuercetinThe serum concentration of Sphingosine can be increased when it is combined with Quercetin.
QuinacrineThe serum concentration of Sphingosine can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Sphingosine can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Sphingosine can be increased when it is combined with Quinine.
RanitidineThe serum concentration of Sphingosine can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Sphingosine can be increased when it is combined with Ranolazine.
ReboxetineThe serum concentration of Sphingosine can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Sphingosine can be increased when it is combined with Regorafenib.
ReserpineThe serum concentration of Sphingosine can be decreased when it is combined with Reserpine.
RifampicinThe serum concentration of Sphingosine can be decreased when it is combined with Rifampicin.
RilpivirineThe serum concentration of Sphingosine can be increased when it is combined with Rilpivirine.
RitonavirThe serum concentration of Sphingosine can be decreased when it is combined with Ritonavir.
RolapitantThe serum concentration of Sphingosine can be increased when it is combined with Rolapitant.
SaquinavirThe serum concentration of Sphingosine can be decreased when it is combined with Saquinavir.
ScopolamineThe serum concentration of Sphingosine can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Sphingosine can be increased when it is combined with Selegiline.
SertralineThe serum concentration of Sphingosine can be increased when it is combined with Sertraline.
SimeprevirThe serum concentration of Sphingosine can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Sphingosine can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Sphingosine can be decreased when it is combined with Sirolimus.
SorafenibThe serum concentration of Sphingosine can be increased when it is combined with Sorafenib.
SpironolactoneThe serum concentration of Sphingosine can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Sphingosine can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Sphingosine can be increased when it is combined with Staurosporine.
StreptozocinThe serum concentration of Sphingosine can be decreased when it is combined with Streptozocin.
SulfinpyrazoneThe serum concentration of Sphingosine can be increased when it is combined with Sulfinpyrazone.
SumatriptanThe serum concentration of Sphingosine can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Sphingosine can be increased when it is combined with Sunitinib.
TacrineThe serum concentration of Sphingosine can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Sphingosine can be decreased when it is combined with Tacrolimus.
TamoxifenThe serum concentration of Sphingosine can be decreased when it is combined with Tamoxifen.
Taurocholic AcidThe serum concentration of Sphingosine can be increased when it is combined with Taurocholic Acid.
TelmisartanThe serum concentration of Sphingosine can be increased when it is combined with Telmisartan.
TemsirolimusThe serum concentration of Sphingosine can be increased when it is combined with Temsirolimus.
TerazosinThe serum concentration of Sphingosine can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Sphingosine can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Sphingosine can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Sphingosine can be increased when it is combined with Testosterone.
TicagrelorThe serum concentration of Sphingosine can be increased when it is combined with Ticagrelor.
TolvaptanThe serum concentration of Sphingosine can be increased when it is combined with Tolvaptan.
TrazodoneThe serum concentration of Sphingosine can be decreased when it is combined with Trazodone.
TrifluoperazineThe serum concentration of Sphingosine can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Sphingosine can be increased when it is combined with Triflupromazine.
TrimethoprimThe serum concentration of Sphingosine can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Sphingosine can be increased when it is combined with Trimipramine.
TroleandomycinThe serum concentration of Sphingosine can be increased when it is combined with Troleandomycin.
VenlafaxineThe serum concentration of Sphingosine can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Sphingosine can be decreased when it is combined with Verapamil.
VinblastineThe serum concentration of Sphingosine can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Sphingosine can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Sphingosine can be increased when it is combined with Vinorelbine.
ZimelidineThe serum concentration of Sphingosine can be increased when it is combined with Zimelidine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Lipid binding
Specific Function:
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.
Gene Name:
GLTP
Uniprot ID:
Q9NZD2
Molecular Weight:
23849.6 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Poliovirus type 1 (strain Mahoney)
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor PVR to provide virion attachment to targe...
Gene Name:
Not Available
Uniprot ID:
P03300
Molecular Weight:
246538.14 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
HRV-14
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host ICAM1 to provide virion attachment to target host cells...
Gene Name:
Not Available
Uniprot ID:
P03303
Molecular Weight:
242989.38 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
SVDV
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host CXADR to provide virion attachment to target host cells...
Gene Name:
Not Available
Uniprot ID:
P13900
Molecular Weight:
243363.48 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor to provide virion attachment to target ho...
Gene Name:
Not Available
Uniprot ID:
P03302
Molecular Weight:
246162.675 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Virus receptor activity
Specific Function:
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. Ma...
Gene Name:
PVR
Uniprot ID:
P15151
Molecular Weight:
45302.3 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M: Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells. Biosci Biotechnol Biochem. 2004 Dec;68(12):2541-6. [PubMed:15618625 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23