You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NamePhenol
Accession NumberDB03255  (EXPT01917)
TypeSmall Molecule
GroupsApproved, Experimental
Description

Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization. Research indicates that parental exposure to phenol and its related compounds are positively associated with spontaneous abortion. During the second world war, phenol injections were used as a means of execution by the Nazis. Phenol is a toxic compound whose vapours are corrosive to the skin, eyes, and respiratory tract.

Structure
Thumb
Synonyms
Acide carbolique
Acide phenique
Benzenol
Carbolic acid
Carbolsaeure
Hydroxybenzene
Karbolsaeure
Monohydroxybenzene
Oxybenzene
Phenic Acid
Phenol
Phenyl alcohol
Phenyl hydroxide
Phenylic Acid
Phenylic alcohol
PHOH
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Phenol 6%solution6 %intraganglionalSandoz Canada Incorporated1993-12-31Not applicableCanada
Sterile Diluent for Allergenic Extractinjection, solution.004 mL/mLintradermal; subcutaneousAntigen Laboratories, Inc.1974-03-23Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Aseptil Rojoliquid1 mg/mLoralMenper Distributors, Inc.2012-02-21Not applicableUs
Care One Sore Throatspray1.4 g/100mLoralAmerican Sales Company2003-11-19Not applicableUs
Castellani Paintliquid15 mg/mLtopicalStratus Pharamceuticals2014-04-01Not applicableUs
Castellani Paintliquid15 mg/mLtopicalPedinol Pharmacal, Inc.1972-01-01Not applicableUs
Castellani Paintliquid15 mg/mLtopicalPhysicians Total Care, Inc.2008-05-15Not applicableUs
Castellani Paintliquid15 mg/mLtopicalPedinol Pharmacal, Inc.1972-01-01Not applicableUs
Castellani Paint 1.5%liquid15 mg/mLtopicalThe Podiatree Company2013-07-01Not applicableUs
Castellani Paint 1.5%liquid15 mg/mLtopicalThe Podiatree Company2013-07-01Not applicableUs
Cepastat Cherrylozenge14.5 mg/1oralInsight Pharmaceuticals2009-06-29Not applicableUs
Cepastat Extra Strengthlozenge29 mg/1oralInsight Pharmaceuticals2009-07-07Not applicableUs
Chloraseptic Sore Throatspray3.5 mg/.7mLoralPrestige Brands Holdings, Inc.2010-09-01Not applicableUs
Chloraseptic Sore Throat Cherryspray3.5 mg/.7mLoralPrestige Brands Holdings, Inc.2010-09-01Not applicableUs
Chloraseptic Sore Throat Citrusspray3.5 mg/.7mLoralPrestige Brands Holdings, Inc.2010-09-01Not applicableUs
Chloraseptic Sore Throat Mentholspray3.5 mg/.7mLoralPrestige Brands Holdings, Inc.2010-09-01Not applicableUs
Chloraseptic Warming Sore Throatspray3.5 mg/.7mLoralPrestige Brands Holdings, Inc.2012-07-01Not applicableUs
Dg Health Sore Throatspray1.4 g/100mLoralDolgencorp, LLC2010-01-17Not applicableUs
Eos Medicated Pain Relieving Lip Balmstick.68 g/7gtopicalEos Products Llc2011-08-31Not applicableUs
Eos Medicated Pain Relieving Lip Balmstick.68 g/7gtopicalEos Products Llc2011-08-31Not applicableUs
Equaline Sore Throatspray1.4 g/100mLoralSupervalu Inc2004-08-30Not applicableUs
Equate Sore Throatspray1.4 g/100mLoralWal Mart Stores Inc2005-06-28Not applicableUs
Good Neighbor Pharmacy Sore Throatspray1.4 mL/100mLoralAmerisource Bergen1993-04-09Not applicableUs
Good Neighbor Pharmacy Sore Throatspray1.4 mL/100mLoralAmerisource Bergen1994-01-03Not applicableUs
Good Sense Sore Throatspray1.4 g/100mLoralL Perrigo Company1993-01-06Not applicableUs
Healthy Accents Sore Throatspray1.4 mL/100mLoralDZA Brands LLC2008-02-18Not applicableUs
Leader Sore Throatspray1.4 mL/100mLoralCardinal Health2000-11-04Not applicableUs
Leader Sore Throatspray10.628 mg/100mLoralCardinal Health2000-11-07Not applicableUs
Oral Reliefspray1.4 g/100mLoralWalgreens2012-02-01Not applicableUs
Pain A Layliquid1.4 %topicalLee Pharmaceuticals Inc.Not applicableNot applicableCanada
Phenolspray1.4 mg/mLoralPURINEPHARMA LLC2015-03-01Not applicableUs
Phenolliquid1.5 g/100mLoralAaron Industries, Inc.2009-08-01Not applicableUs
Phenolspray1.4 g/100mLoralPerrigo New York Inc2010-12-09Not applicableUs
Phenolspray1.4 mL/100mLoralPerrigo New York Inc2011-06-29Not applicableUs
Phylorinolliquid.25 mg/100mLoralSchaffer Laboratories2014-03-05Not applicableUs
Rx Act Sore Throatspray1.4 mL/100mLoralH E B1994-10-25Not applicableUs
Smart Sense Sore Throatspray1.4 g/100mLoralKmart Corporation2010-12-16Not applicableUs
Sore Throatspray1.5 g/100mLoralGood Sense (Geiss, Destin & Dunn, Inc.)2014-09-30Not applicableUs
Sore Throatspray1.4 g/100mLoralEQUATE (Walmart Stores, Inc.)2014-07-31Not applicableUs
Sore Throatspray1.5 g/100mLoralTOP CARE (Topco Associates LLC)2014-10-31Not applicableUs
Sore Throatspray1.4 mg/100mLoralMeijer Distribution Inc1993-09-03Not applicableUs
Sore Throatspray1.4 g/100mLoralPreferred Plus (Kinray)2014-10-31Not applicableUs
Sore Throatspray1.4 mL/100mLoralH E B1994-10-12Not applicableUs
Sore Throatspray1.4 g/100mLoralPreferred Plus (Kinray)2014-10-31Not applicableUs
Sore Throatspray1.4 g/100mLoralSafeway, Inc.2014-11-30Not applicableUs
Sore Throatspray1.4 g/100mLoralHy Vee Inc1992-11-19Not applicableUs
Sore Throatspray1.5 g/100mLoralGood Sense (Geiss, Destin & Dunn, Inc.)2014-09-30Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralKinray, Inc2009-08-01Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralSelect Brand2009-06-17Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralMajor Pharmaceuticals2012-09-01Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralCardinal Health (Leader) 497812014-07-31Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralMc Kesson (Health Mart)2014-07-31Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralSMART SENSE (Kmart)2014-11-30Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralHealth Mart2012-01-01Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralPublix Supermarkets, Inc.2014-09-30Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralMEIJER, INC.2014-05-01Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralREMEDYREPACK INC.2015-09-08Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralRugby2012-02-01Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralAmerisource Bergen (Good Neighbor Pharmacy) 461222014-07-31Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralBest Choice2009-08-01Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralFamily Dollar2009-08-01Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralQUALITY CHOICE (Chain Drug Marketing Association)2014-08-31Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralFamily Dollar (FAMILY WELLNESS)2014-06-30Not applicableUs
Sore Throat Cherryliquid1.5 g/100mLoralWalgreens2012-02-01Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralMc Kesson (Sunmark)2014-09-30Not applicableUs
Sore Throat Cherryspray1.4 g/100mLoralWalgreens2014-08-31Not applicableUs
Sore Throat Mentholspray1.4 g/100mLoralCare One (American Sales Company)2014-05-01Not applicableUs
Sore Throat Mentholspray1.4 g/100mLoralPublix Supermarkets, Inc.2014-09-30Not applicableUs
Sore Throat Mentholliquid1.5 g/100mLoralBest Choice (Valu Merchandisers Company)2009-08-01Not applicableUs
Sore Throat Mentholliquid1.4 g/100mLoralAmerisource Bergen (Good Neighbor Pharmacy) 461222014-08-31Not applicableUs
Sore Throat Mentholliquid1.4 g/100mLoralQUALITY CHOICE (Chain Drug Marketing Association)2014-08-31Not applicableUs
Sore Throat Mentholliquid1.5 g/100mLoralKinray, Inc2009-08-01Not applicableUs
Sore Throat Readyincasespray1.4 g/100mLoralAaron Industries Inc.2014-11-30Not applicableUs
Sore Throat Reliefliquid1.4 g/100mLoralWestern Family Foods, Inc.2014-06-30Not applicableUs
Sore Throat Reliefliquid1.4 g/100mLoralWestern Family Foods, Inc.2014-06-30Not applicableUs
Sore Throat Reliefspray1.4 g/100mLoralWin Co Foods, Llc2014-12-31Not applicableUs
Sore Throat Relief Cherryspray1.4 g/100mLoralBest Choice (Valu Merchandisers Company)2014-08-29Not applicableUs
Sore Throat Relief Cherry Flavorspray1.4 g/100mLoralChain Drug Consortium2014-12-31Not applicableUs
Sore Throat Relief Mentholspray1.4 g/100mLoralChain Drug Consortium2014-12-31Not applicableUs
Sore Throat Sprayspray10.628 mg/100mLoralKroger Company1993-01-21Not applicableUs
Sore Throat Sprayspray10.268 mg/100mLoralCVS Pharmacy2005-06-06Not applicableUs
Sore Throat Sprayspray1.4 mL/100mLoralSafeway1993-08-11Not applicableUs
Sore Throat Spray Cherryliquid1.5 g/100mLoralAaron Industries, Inc.2009-08-01Not applicableUs
Sunmark Sore Throatspray1.4 mL/100mLoralMc Kesson2003-09-14Not applicableUs
Sunmark Sore Throatspray1.4 mL/100mLoralMc Kesson2003-07-10Not applicableUs
Throat Reliefspray10.628 mg/100mLoralWestern Family Foods Inc1999-04-07Not applicableUs
Topcare Sore Throatspray1.4 mL/100mLoralTopco Associates LLC1993-01-19Not applicableUs
Topcare Sore Throatspray1.4 g/100mLoralTopco Associates LLC1992-11-17Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Liver Supplementpowder.8 g/100goralBionutrigen Co., Ltd.2011-09-15Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
"diluent for Allergenic Extract Sterile Normal Saline With Phenol (0.4%)"Jubilant Hollisterstier Llc
Ambix First AidOrganics Corporation Of America Dba Ambix Laboratories
Anbesol GelWyeth Consumer Healthcare Inc.
Anbesol LiquidWyeth Consumer Healthcare Inc.
Anbesol Maximum Strength LiquidWyeth Consumer Healthcare Inc.
Au Kah Chuen Skin LotionWing Quon Enterprises Ltd.
Balzarol OntRolmex International Inc.
Banana Boat Medicated Lip BalmThe Banana Boat Company
Bite ReliefPic Corporation
Blistex DctBlistex Corporation
Blistex LipHART Health
Blistex MedicatedBlistex Inc.
Budpak First AidBudpak Inc.
Calamine Phenolated Topical SuspensionHumco Holding Group, Inc
Campho Phenique Cold Sore TreatmentBayer Health Care Llc, Consumer Care
Campho-phenique Antiseptic GelBayer Health Care Llc, Consumer Care
Campho-phenique Pain Relieving Antiseptic LiquidCampho Phenique? Liquid
Camphor (synthetic) and PhenolCVS
Carmex Lip BalmCarma Laboratories Inc
Carmex Lip OintmentCarma Laboratories Inc
Chapice Camphor Phenol GelOra Labs
Chapstick MedicatedPfizer Consumer Healthcare
Chapstick Medicated Lip Balm - JarWhitehall Robins Inc.
Chapstick Medicated Lip Balm - StkWhitehall Robins Inc.
Chapstick Medicated Lip Balm - TubeWhitehall Robins Inc.
ChigaridColgin Inc
Chloraseptic Sore Throat MaxPrestige Brands Holdings, Inc.
Coghlan S Sting ReliefCoghlan's Ltd
Dermaphy OntProduits Phyto Inc.
Diluent SterileOmega Laboratories Ltd
Instant Antiseptic Pain ReliefChain Drug Market Association
Leader Camphor Phenol GelCardinal Health (Leader)
Lip Conditioner Lip BalmBlistex Corporation
Major Camphor and PhenolMajor Pharmaceuticals
Makesense First AidCherry Hill Sales Co
Mecca OintmentThe Mentholatum Company Of Canada Ltd
Medicated Blistex Dct Lip BalmBlistex Corporation
Medicated Lip BalmWalgreen Co
Medicated LipbalmNorwood Packaging Ltd
Natur 911Bratch Laboratories
Off Bite and Itch Relief First Aid AntisepticS. C. Johnson & Son, Inc.
Ozonol OntSterling Winthrop Inc.
Phen-oris - Ont TopGermiphene Corporation
Phenol Saline InjAlk Abello Inc
Phenoris OntE L Stickley And Co Ltd.
Poison OakDe Martini Spring Hill Pharmacy, Inc.
Preferred Plus Medicated Lip BalmKinray
Shopko Camphor Phenol GelShopko
Sterile Diluent for Allergenic ExtractAntigen Laboratories, Inc.
Sting EzeWisconsin Pharmacal Co. Llc
Sting Kure - LiqWisconsin Pharmacal Co. Llc
Sting-eze-liqWisconsin Pharmacal Co. Llc
Stingeze Insect Bite ReliefWisconsin Pharmacal Company
Stingeze Max Insect Bite ReliefWisconsin Pharmacal Company
Sunmark Phenolated CalamineMc Kesson
Vaseline Brand Lip Therapy Medicated TubeChesebrough Pond's Canada
Yat Tip XiaoHuangshi Hygenic Material Pharmacy Co. Ltd.
SaltsNot Available
Categories
UNII339NCG44TV
CAS number108-95-2
WeightAverage: 94.1112
Monoisotopic: 94.041864814
Chemical FormulaC6H6O
InChI KeyInChIKey=ISWSIDIOOBJBQZ-UHFFFAOYSA-N
InChI
InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
IUPAC Name
phenol
SMILES
OC1=CC=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenols and derivatives. These are compounds containing a phenol moiety, which is a benzene bearing a hydroxyl group.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenols and derivatives
Direct ParentPhenols and derivatives
Alternative Parents
Substituents
  • Phenol
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationPhenol is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity.
PharmacodynamicsNot Available
Mechanism of actionPhenol is a potent proteolytic agent. Concentrations in the 5% to 7% range dissolve tissue on contact via proteolysis. In high concentrations when injected next to a nerve, phenol produces a chemical neurolysis which is nonselective across nerve fiber size and most prominent on its outer aspect. Local anesthetic effects occur within 5-10 minutes.
Related Articles
AbsorptionPhenol is rapidly absorbed through the skin and into the lungs.
Volume of distribution

At I5 min after exposure, the liver contained the highest level of phenol, consisting mainly of free phenol. After 82 minutes post administration, phenol is uniformly distributed in the liver, blood, kidneys, lungs, along with the heart, testes, thymus and the spleen. With the passage of time, the proportion of free to conjugated phenol changed. By 360 minutes most phenol appears in conjugated forms.

Protein bindingNot Available
Metabolism

Phenyl sulfate, phenyl glucuronide, quinol sulfate, and quinol glucuronide were detected in human beings as phenol metabolites.

Route of eliminationThe kidney is the primary route of elimination of phenol.
Half lifeNot Available
Clearance

In rabbits, 72% is excreted in the urine, 1% in the feces, 4% in the carcass following sacrifice, and trace amounts were exhaled.

ToxicityMouse, Subcutaneous, LD50: 0.3-0.35 g/kg. (Duplay and Cazin, 1891; Tollens, 1905). Rat, Subcutaneous, LD50: 0.45. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.53. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.65. (Flickinger, 1976). Rat, Cutaneous, LD50: 0.67. (Conning and Hayes, 1970).
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Sulfate/Sulfite MetabolismMetabolicSMP00041
Sulfite oxidase deficiencyDiseaseSMP00532
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9931
Blood Brain Barrier+0.9076
Caco-2 permeable+0.9326
P-glycoprotein substrateNon-substrate0.8082
P-glycoprotein inhibitor INon-inhibitor0.979
P-glycoprotein inhibitor IINon-inhibitor0.9917
Renal organic cation transporterNon-inhibitor0.8704
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7558
CYP450 1A2 substrateNon-inhibitor0.6114
CYP450 2C9 inhibitorNon-inhibitor0.9654
CYP450 2D6 inhibitorNon-inhibitor0.9746
CYP450 2C19 inhibitorNon-inhibitor0.8981
CYP450 3A4 inhibitorNon-inhibitor0.9523
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8695
Ames testNon AMES toxic0.9454
CarcinogenicityNon-carcinogens0.7594
BiodegradationReady biodegradable0.7488
Rat acute toxicity2.5044 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8468
hERG inhibition (predictor II)Non-inhibitor0.9666
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Liquidintradermal; subcutaneous; percutaneous
Creamtopical
Geloral
Liquidbuccal
Liquidoral
Liquidoral1 mg/mL
Ointmenttopical
Lotiontopical
Geltopical
Liquidtopical
Liquidtopical15 mg/mL
Lozengeoral14.5 mg/1
Lozengeoral29 mg/1
Sprayoral3.5 mg/.7mL
Sprayoral
Spongetopical
Liquidsubcutaneous
Sticktopical.68 g/7g
Sprayoral1.4 g/100mL
Powderoral.8 g/100g
Salvetopical
Sticktopical
Solutiontopical
Liquidtopical1.4 %
Sprayoral1.4 mg/mL
Solutionintraganglional6 %
Liquidintradermal; subcutaneous
Liquidoral.25 mg/100mL
Sprayoral1.4 mg/100mL
Sprayoral1.5 g/100mL
Liquidoral1.5 g/100mL
Liquidoral1.4 g/100mL
Sprayoral1.4 mL/100mL
Sprayoral10.268 mg/100mL
Sprayoral10.628 mg/100mL
Injection, solutionintradermal; subcutaneous
Injection, solutionintradermal; subcutaneous.004 mL/mL
Plastertopical
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point40.9 °CPhysProp
boiling point181.8 °CPhysProp
water solubility8.28E+004 mg/L (at 25 °C)SOUTHWORTH,GR & KELLER,JL (1986)
logP1.46HANSCH,C ET AL. (1995)
logS0ADME Research, USCD
pKa9.99 (at 25 °C)SERJEANT,EP & DEMPSEY,B (1979)
Predicted Properties
PropertyValueSource
Water Solubility46.6 mg/mLALOGPS
logP1.39ALOGPS
logP1.67ChemAxon
logS-0.31ALOGPS
pKa (Strongest Acidic)10.02ChemAxon
pKa (Strongest Basic)-5.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity28.04 m3·mol-1ChemAxon
Polarizability9.81 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.52 KB)
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MS (1 TMS)splash10-0udi-3900000000-97dfa3be718a9ee7ace4View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Negative (Annotated)splash10-0006-9000000000-e67da0571423f0e6b4b8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Negative (Annotated)splash10-0006-9000000000-e0f57b1e970d0d46597eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Negative (Annotated)splash10-0006-9000000000-e67da0571423f0e6b4b8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-7M) , Positivesplash10-00kf-9000000000-7bfe3b897e928a8f3a2cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (JEOL JMS-01-SG-2) , Positivesplash10-0006-9000000000-78c83ab6ff1d3dfdbec6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-6L) , Positivesplash10-0006-9000000000-89b0c430b8924ee2afdeView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (JEOL JMS-D-3000) , Positivesplash10-0006-9000000000-fc01d0ad6740cfd70e13View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-80B) , Positivesplash10-0006-9000000000-ca4fa5905cccbfeab33aView in MoNA
MSMass Spectrum (Electron Ionization)splash10-00kf-9000000000-40b376f4e58c23369a01View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

http://en.wikipedia.org/wiki/Phenols#Synthesis_of_phenols

General References
  1. Chen X, Chen M, Xu B, Tang R, Han X, Qin Y, Xu B, Hang B, Mao Z, Huo W, Xia Y, Xu Z, Wang X: Parental phenols exposure and spontaneous abortion in Chinese population residing in the middle and lower reaches of the Yangtze River. Chemosphere. 2013 Sep;93(2):217-22. doi: 10.1016/j.chemosphere.2013.04.067. Epub 2013 May 25. [PubMed:23714150 ]
  2. Gracies JM, Elovic E, McGuire J, Simpson DM: Traditional pharmacological treatments for spasticity. Part I: Local treatments. Muscle Nerve Suppl. 1997;6:S61-91. [PubMed:9826983 ]
  3. Babich H, Davis DL: Phenol: a review of environmental and health risks. Regul Toxicol Pharmacol. 1981 Jun;1(1):90-109. [PubMed:6764550 ]
External Links
ATC CodesC05BB05D08AE03N01BX03R02AA19
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSDownload (51.6 KB)
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Geobacillus stearothermophilus
Pharmacological action
unknown
General Function:
Metalloendopeptidase activity
Specific Function:
Extracellular zinc metalloprotease.
Gene Name:
nprS
Uniprot ID:
P43133
Molecular Weight:
60616.22 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Enterobacteria phage T4
Pharmacological action
unknown
General Function:
Lysozyme activity
Specific Function:
Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
Gene Name:
E
Uniprot ID:
P00720
Molecular Weight:
18691.385 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
unknown
General Function:
Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Specific Function:
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
Gene Name:
cobT
Uniprot ID:
Q05603
Molecular Weight:
36612.305 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:20