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targets (16)
for drugs
Identification
Name alpha-D-Xylopyranose
Accession Number DB03389 (EXPT03270)
Type small molecule
Groups experimental
Description Not Available
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names Not Available
Brand mixtures Not Available
Categories Not Available
CAS number Not Available
Weight Average: 150.1299
Monoisotopic: 150.05282343
Chemical Formula C5H10O5
InChI Key InChIKey=SRBFZHDQGSBBOR-LECHCGJUSA-N
InChI
InChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3+,4-,5+/m1/s1
Plain Text
IUPAC Name
(2S,3R,4S,5R)-oxane-2,3,4,5-tetrol
SMILES
O[C@@H]1CO[C@H](O)[C@H](O)[C@H]1O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 1.22e+03 g/l ALOGPS
logP -2.6 ALOGPS
logP -2.3 ChemAxon
logS 0.91 ALOGPS
pKa (strongest acidic) 11.31 ChemAxon
pKa (strongest basic) -3.5 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 5 ChemAxon
hydrogen donor count 4 ChemAxon
polar surface area 90.15 ChemAxon
rotatable bond count 0 ChemAxon
refractivity 29.96 ChemAxon
polarizability 13.18 ChemAxon
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
KEGG Compound C02205 Link_out
ChEBI 28518 Link_out
ChEMBL 28518 Link_out
HET XYS Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Chondroitinase B

Pharmacological action: unknown

Cleaves the glycosaminoglycan, dermatan sulfate

Organism class: bacterial
UniProt ID: Q46079 Link_out
Gene: cslB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. Chondroitinase AC

Pharmacological action: unknown

Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4- enuronosyl groups

Organism class: bacterial
UniProt ID: Q59288 Link_out
Gene: cslA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

3. Exoglucanase/xylanase [Includes: Exoglucanase

Pharmacological action: unknown

The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes:(1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) Beta-1,4- glucosidases which hydrolyze the cellobiose and other short cello- oligosaccharides to glucose

Organism class: bacterial
UniProt ID: P07986 Link_out
Gene: cex
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. Aldose 1-epimerase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9ZB17 Link_out
Gene: galM
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

5. Endo-beta-1,4-xylanase

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans

Organism class: bacterial
UniProt ID: Q59675 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

6. Xylanase Y

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9KB30 Link_out
Gene: BH2105
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

7. Endo-1,4-beta-xylanase

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans

Organism class: bacterial
UniProt ID: P40943 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

8. Glycoside hydrolase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7SIE2 Link_out
Protein Sequence: FASTA

9. Endo-1,4-beta-xylanase A

Pharmacological action: unknown

Endoxylanase that degrades arabinoxylan and glucuronoxylan to xylobiose and xylotriose (in vitro)

Organism class: bacterial
UniProt ID: Q8GJ44 Link_out
Gene: xynA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

10. Endo-1,4-beta-xylanase A

Pharmacological action: unknown

Contributes to hydrolyze hemicellulose, the major component of plant cell-walls. XLNA and XLNB seem to act sequentially on the substrate to yield xylobiose and xylose as carbon sources

Organism class: bacterial
UniProt ID: P26514 Link_out
Gene: xlnA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

11. Endo-1,4-beta-xylanase

Pharmacological action: unknown

Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans

Organism class: bacterial
UniProt ID: P09850 Link_out
Gene: xlnA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

12. Hydrolase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7SI98 Link_out
Protein Sequence: FASTA

13. Endo-1,4-beta-xylanase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q8RJN8 Link_out
Gene: xyl
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

14. Lactase-phlorizin hydrolase

Pharmacological action: unknown

LPH splits lactose in the small intestine

Organism class: human
UniProt ID: P09848 Link_out
Gene: LCT Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

15. Endoxylanase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O68541 Link_out
Gene: xynC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

16. Beta-amylase

Pharmacological action: unknown

Hydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains

Organism class: bacterial
UniProt ID: P36924 Link_out
Gene: spoII
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:22