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targets (15)
for drugs
Identification
Name Cysteinesulfonic Acid
Accession Number DB03661 (EXPT02415)
Type small molecule
Groups experimental
Description

Beta-Sulfoalanine. An amino acid with a C-terminal sulfonic acid group which has been isolated from human hair oxidized with permanganate. It occurs normally in the outer part of the sheep's fleece, where the wool is exposed to light and weather. [PubChem]
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names Not Available
Brand mixtures Not Available
Categories Not Available
CAS number Not Available
Weight Average: 169.156
Monoisotopic: 169.004493029
Chemical Formula C3H7NO5S
InChI Key InChIKey=XVOYSCVBGLVSOL-REOHCLBHSA-N
InChI
InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1
Plain Text
IUPAC Name
(2R)-2-amino-3-sulfopropanoic acid
SMILES
N[C@@H](CS(O)(=O)=O)C(O)=O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 7.36e+01 g/l ALOGPS
logP -2.4 ALOGPS
logP -3 ChemAxon
logS -0.36 ALOGPS
pKa (strongest acidic) -1.7 ChemAxon
pKa (strongest basic) 8.79 ChemAxon
physiological charge -1 ChemAxon
hydrogen acceptor count 6 ChemAxon
hydrogen donor count 3 ChemAxon
polar surface area 117.69 ChemAxon
rotatable bond count 3 ChemAxon
refractivity 30.44 ChemAxon
polarizability 13.48 ChemAxon
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
PubChem Compound 72886 Link_out
PubChem Substance 46508940 Link_out
ChEBI 17285 Link_out
ChEMBL 17285 Link_out
HET OCS Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Metallo beta-lactamase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9K2N0 Link_out
Gene: blaVIM-2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

2. Sugar-phosphate isomerase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9X0G9 Link_out
Gene: TM_1080
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

3. Cathepsin L

Pharmacological action: unknown

Important for the overall degradation of proteins in lysosomes

Organism class: human
UniProt ID: P07711 Link_out
Gene: CTSL Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

4. Methylaspartate ammonia-lyase

Pharmacological action: unknown

L-threo-3-methylaspartate = mesaconate + NH(3)

Organism class: bacterial
UniProt ID: Q05514 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

5. Peroxiredoxin

Pharmacological action: unknown
Organism class: parasitic
UniProt ID: Q5MYR6 Link_out
Gene: prx
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

6. Peptide deformylase

Pharmacological action: unknown

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)

Organism class: bacterial
UniProt ID: P43522 Link_out
Gene: def
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

7. Golgi-associated plant pathogenesis-related protein 1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9H4G4 Link_out
Gene: GLIPR2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

8. Hypothetical protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9X0P2 Link_out
Gene: TM_1158
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

9. Peptide deformylase

Pharmacological action: unknown

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)

Organism class: bacterial
UniProt ID: P96113 Link_out
Gene: def
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

10. 3-oxoacyl-[acyl-carrier-protein] synthase 3

Pharmacological action: unknown

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain

Organism class: bacterial
UniProt ID: P0A6R0 Link_out
Gene: fabH
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

11. Tyrosine-protein phosphatase non-receptor type 1

Pharmacological action: unknown

May play an important role in CKII- and p60c-src-induced signal transduction cascades

Organism class: human
UniProt ID: P18031 Link_out
Gene: PTPN1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

12. Penicillin acylase

Pharmacological action: unknown

The enzyme catalyzes the conversion of penicillin to 6- aminopenicillanate The precursor, furthermore, acts as a self- processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase

Organism class: bacterial
UniProt ID: P12256 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

13. S-ribosylhomocysteine lyase

Pharmacological action: unknown

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)

Organism class: bacterial
UniProt ID: O34667 Link_out
Gene: luxS
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

14. Deoxynucleotide monophosphate kinase

Pharmacological action: unknown

Acts on dGMP, dTMP and 5-hydroxymethyl-dCMP while excluding dCMP and dAMP

Organism class: viral
UniProt ID: P04531 Link_out
Gene: 1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

15. M-phase inducer phosphatase 2

Pharmacological action: unknown

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. The three isoforms seem to have a different level of activity

Organism class: human
UniProt ID: P30305 Link_out
Gene: CDC25B Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:22