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Identification
NameP-Nitrophenol
Accession NumberDB04417  (EXPT02385)
TypeSmall Molecule
GroupsExperimental
DescriptionNot Available
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIY92ZL45L4R
CAS number100-02-7
WeightAverage: 139.1088
Monoisotopic: 139.026943031
Chemical FormulaC6H5NO3
InChI KeyInChIKey=BTJIUGUIPKRLHP-UHFFFAOYSA-N
InChI
InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H
IUPAC Name
4-nitrophenol
SMILES
OC1=CC=C(C=C1)[N+]([O-])=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as nitrophenols and derivatives. These are compounds containing a nitrophenol moiety, which consists of a benzene ring bearing both a hydroxyl group and a nitro group on two different ring carbon atoms.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenols and derivatives
Direct ParentNitrophenols and derivatives
Alternative Parents
Substituents
  • Nitrophenol derivative
  • Nitrobenzene
  • Organic nitro compound
  • Organic nitrite
  • C-nitro compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Allyl-type 1,3-dipolar organic compound
  • Organic oxoazanium
  • Hydrocarbon derivative
  • Organic salt
  • Organooxygen compound
  • Organonitrogen compound
  • Organic zwitterion
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationNot Available
PharmacodynamicsNot Available
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9864
Blood Brain Barrier+0.7201
Caco-2 permeable+0.5667
P-glycoprotein substrateNon-substrate0.8778
P-glycoprotein inhibitor INon-inhibitor0.8776
P-glycoprotein inhibitor IINon-inhibitor0.9865
Renal organic cation transporterNon-inhibitor0.8919
CYP450 2C9 substrateNon-substrate0.7621
CYP450 2D6 substrateNon-substrate0.8076
CYP450 3A4 substrateNon-substrate0.5179
CYP450 1A2 substrateInhibitor0.5893
CYP450 2C9 inhibitorNon-inhibitor0.8259
CYP450 2D6 inhibitorNon-inhibitor0.952
CYP450 2C19 inhibitorNon-inhibitor0.8826
CYP450 3A4 inhibitorNon-inhibitor0.8723
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.812
Ames testNon AMES toxic0.7376
CarcinogenicityNon-carcinogens0.5316
BiodegradationNot ready biodegradable0.7261
Rat acute toxicity2.7067 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.6671
hERG inhibition (predictor II)Non-inhibitor0.9204
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point113.8 °CPhysProp
boiling point279 °CPhysProp
water solubility1.16E+004 mg/L (at 20 °C)SCHWARZENBACH,RP ET AL (1988)
logP1.91HANSCH,C ET AL. (1995)
logS-0.74ADME Research, USCD
pKa7.15 (at 25 °C)SERJEANT,EP & DEMPSEY,B (1979)
Predicted Properties
PropertyValueSource
Water Solubility3.6 mg/mLALOGPS
logP1.93ALOGPS
logP1.61ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)7.04ChemAxon
pKa (Strongest Basic)-7.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area66.05 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity35.36 m3·mol-1ChemAxon
Polarizability12.18 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MSNot Available
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-00dl-0900000000-653240f82298b3880e70View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-014l-9100000000-1dd6a69ee33aeb4207a3View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-014r-9000000000-397a0913b382e58ae418View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-7M) , Positivesplash10-00kr-9200000000-039471e02c3307757a0cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-6M) , Positivesplash10-00or-9500000000-a23a22fc322241325904View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (Unknown) , Positivesplash10-000i-9400000000-12717928037244536b6bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-60) , Positivesplash10-000i-9400000000-f133ed564f0a12bd3871View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-80) , Positivesplash10-05n0-9300000000-d39a8dbf21962717a2eeView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0002-9200000000-bff0a2a3c15629cc6ec2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-052r-0900000000-1279a141e229fec8dbd4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-00kr-9300000000-d76f14df8da868057d44View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with P-Nitrophenol.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with P-Nitrophenol.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with P-Nitrophenol.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with P-Nitrophenol.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with P-Nitrophenol.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with P-Nitrophenol.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with P-Nitrophenol.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with P-Nitrophenol.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with P-Nitrophenol.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with P-Nitrophenol.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with P-Nitrophenol.
AtenololThe serum concentration of Atenolol can be increased when it is combined with P-Nitrophenol.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with P-Nitrophenol.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with P-Nitrophenol.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with P-Nitrophenol.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with P-Nitrophenol.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with P-Nitrophenol.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with P-Nitrophenol.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with P-Nitrophenol.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with P-Nitrophenol.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with P-Nitrophenol.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with P-Nitrophenol.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with P-Nitrophenol.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with P-Nitrophenol.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with P-Nitrophenol.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with P-Nitrophenol.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with P-Nitrophenol.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with P-Nitrophenol.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with P-Nitrophenol.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with P-Nitrophenol.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with P-Nitrophenol.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with P-Nitrophenol.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with P-Nitrophenol.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with P-Nitrophenol.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with P-Nitrophenol.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with P-Nitrophenol.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with P-Nitrophenol.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with P-Nitrophenol.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with P-Nitrophenol.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with P-Nitrophenol.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with P-Nitrophenol.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with P-Nitrophenol.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with P-Nitrophenol.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with P-Nitrophenol.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with P-Nitrophenol.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with P-Nitrophenol.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with P-Nitrophenol.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with P-Nitrophenol.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with P-Nitrophenol.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with P-Nitrophenol.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with P-Nitrophenol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with P-Nitrophenol.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with P-Nitrophenol.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with P-Nitrophenol.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with P-Nitrophenol.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with P-Nitrophenol.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with P-Nitrophenol.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with P-Nitrophenol.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with P-Nitrophenol.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with P-Nitrophenol.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with P-Nitrophenol.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with P-Nitrophenol.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with P-Nitrophenol.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with P-Nitrophenol.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with P-Nitrophenol.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with P-Nitrophenol.
EstriolThe serum concentration of Estriol can be increased when it is combined with P-Nitrophenol.
EstroneThe serum concentration of Estrone can be increased when it is combined with P-Nitrophenol.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with P-Nitrophenol.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with P-Nitrophenol.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with P-Nitrophenol.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with P-Nitrophenol.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with P-Nitrophenol.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with P-Nitrophenol.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with P-Nitrophenol.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with P-Nitrophenol.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with P-Nitrophenol.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with P-Nitrophenol.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with P-Nitrophenol.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with P-Nitrophenol.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with P-Nitrophenol.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with P-Nitrophenol.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with P-Nitrophenol.
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with P-Nitrophenol.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with P-Nitrophenol.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with P-Nitrophenol.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with P-Nitrophenol.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with P-Nitrophenol.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with P-Nitrophenol.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with P-Nitrophenol.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with P-Nitrophenol.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with P-Nitrophenol.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with P-Nitrophenol.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with P-Nitrophenol.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with P-Nitrophenol.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with P-Nitrophenol.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with P-Nitrophenol.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with P-Nitrophenol.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with P-Nitrophenol.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with P-Nitrophenol.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with P-Nitrophenol.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with P-Nitrophenol.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with P-Nitrophenol.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with P-Nitrophenol.
LosartanThe serum concentration of Losartan can be increased when it is combined with P-Nitrophenol.
MannitolThe serum concentration of Mannitol can be increased when it is combined with P-Nitrophenol.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with P-Nitrophenol.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with P-Nitrophenol.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with P-Nitrophenol.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with P-Nitrophenol.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with P-Nitrophenol.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with P-Nitrophenol.
MorphineThe serum concentration of Morphine can be increased when it is combined with P-Nitrophenol.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with P-Nitrophenol.
NadololThe serum concentration of Nadolol can be increased when it is combined with P-Nitrophenol.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with P-Nitrophenol.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with P-Nitrophenol.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with P-Nitrophenol.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with P-Nitrophenol.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with P-Nitrophenol.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with P-Nitrophenol.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with P-Nitrophenol.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with P-Nitrophenol.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with P-Nitrophenol.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with P-Nitrophenol.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with P-Nitrophenol.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with P-Nitrophenol.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with P-Nitrophenol.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with P-Nitrophenol.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with P-Nitrophenol.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with P-Nitrophenol.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with P-Nitrophenol.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with P-Nitrophenol.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with P-Nitrophenol.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with P-Nitrophenol.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with P-Nitrophenol.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with P-Nitrophenol.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with P-Nitrophenol.
PropranololThe serum concentration of Propranolol can be increased when it is combined with P-Nitrophenol.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with P-Nitrophenol.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with P-Nitrophenol.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with P-Nitrophenol.
QuinineThe serum concentration of Quinine can be increased when it is combined with P-Nitrophenol.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with P-Nitrophenol.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with P-Nitrophenol.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with P-Nitrophenol.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with P-Nitrophenol.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with P-Nitrophenol.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with P-Nitrophenol.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with P-Nitrophenol.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with P-Nitrophenol.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with P-Nitrophenol.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with P-Nitrophenol.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with P-Nitrophenol.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with P-Nitrophenol.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with P-Nitrophenol.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with P-Nitrophenol.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with P-Nitrophenol.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with P-Nitrophenol.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with P-Nitrophenol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with P-Nitrophenol.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with P-Nitrophenol.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with P-Nitrophenol.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with P-Nitrophenol.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with P-Nitrophenol.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with P-Nitrophenol.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with P-Nitrophenol.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with P-Nitrophenol.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with P-Nitrophenol.
TimololThe serum concentration of Timolol can be increased when it is combined with P-Nitrophenol.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with P-Nitrophenol.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with P-Nitrophenol.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with P-Nitrophenol.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with P-Nitrophenol.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with P-Nitrophenol.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with P-Nitrophenol.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with P-Nitrophenol.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with P-Nitrophenol.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with P-Nitrophenol.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with P-Nitrophenol.
VincristineThe serum concentration of Vincristine can be increased when it is combined with P-Nitrophenol.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with P-Nitrophenol.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with P-Nitrophenol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sulfotransferase activity
Specific Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so ...
Gene Name:
SULT1A1
Uniprot ID:
P50225
Molecular Weight:
34165.13 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
AMY2B
Uniprot ID:
P19961
Molecular Weight:
57709.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. [PubMed:11743742 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:24