N-Formylmethionine

Identification

Generic Name
N-Formylmethionine
DrugBank Accession Number
DB04464
Background

N-Formylmethionine is effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well as in the mitochondria of eucaryotic cells.

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 177.221
Monoisotopic: 177.045963913
Chemical Formula
C6H11NO3S
Synonyms
  • (2S)-2-(formylamino)-4-(methylthio)butanoic acid
  • Formyl-methionine
  • L-N-Formylmethionine
  • N-formyl-L-methionine

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UGeranylgeranyl transferase type-2 subunit alphaNot AvailableHumans
UGeranylgeranyl transferase type-2 subunit betaNot AvailableHumans
UPhotosynthetic reaction center cytochrome c subunitNot AvailableRhodopseudomonas viridis
UReaction center protein H chainNot AvailableRhodopseudomonas viridis
UReaction center protein L chainNot AvailableRhodopseudomonas viridis
UReaction center protein M chainNot AvailableRhodopseudomonas viridis
ULight-harvesting protein B-800/820 alpha chainNot AvailableRhodopseudomonas acidophila
ULight-harvesting protein B-800/820 beta chainNot AvailableRhodopseudomonas acidophila
ULight-harvesting protein B-800/850 alpha chainNot AvailableRhodopseudomonas acidophila
ULight-harvesting protein B-800/850 beta chainNot AvailableRhodopseudomonas acidophila
UAntithrombin-IIINot AvailableHumans
UBeta-2-microglobulinNot AvailableHumans
UNADH-ubiquinone oxidoreductase chain 1Not AvailableHumans
UHLA class I histocompatibility antigen, B-27 alpha chainNot AvailableHumans
URespiratory nitrate reductase 1 alpha chainNot AvailableEscherichia coli (strain K12)
URespiratory nitrate reductase 1 beta chainNot AvailableEscherichia coli (strain K12)
URespiratory nitrate reductase 1 gamma chainNot AvailableEscherichia coli (strain K12)
UProtein S100-GNot AvailableHumans
URubredoxinNot AvailableDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
UCytochrome c oxidase subunit 4 isoform 1, mitochondrialNot AvailableHumans
UCytochrome c oxidase subunit 1Not AvailableHumans
UCytochrome c oxidase subunit 2Not AvailableHumans
UCytochrome c oxidase subunit 3Not AvailableHumans
UCytochrome c oxidase subunit 5A, mitochondrialNot AvailableHumans
UCytochrome c oxidase subunit 5B, mitochondrialNot AvailableHumans
UCytochrome c oxidase subunit 6CNot AvailableHumans
UCytochrome c oxidase subunit 7B, mitochondrialNot AvailableHumans
UCytochrome c oxidase subunit 7C, mitochondrialNot AvailableHumans
UCytochrome c oxidase subunit 8A, mitochondrialNot AvailableHumans
UCytochrome c oxidase subunit 6A2, mitochondrialNot AvailableHumans
UCytochrome c oxidase subunit 6B1Not AvailableHumans
UCytochrome c oxidase subunit 7A1, mitochondrialNot AvailableHumans
UMethionyl-tRNA formyltransferaseNot AvailableEscherichia coli (strain K12)
UStreptavidinNot AvailableStreptomyces avidinii
UProtein S100-BNot AvailableHumans
UDelta-hemolysinNot AvailableStaphylococcus aureus
UPolyubiquitin-CNot AvailableHumans
UAtpHNot AvailableArthrospira platensis HN01
UProbable L-ascorbate-6-phosphate lactonase UlaGNot AvailableEscherichia coli (strain K12)
UImmunoglobulin G-binding protein GNot AvailableStreptococcus sp. group G
UGlutamate--cysteine ligaseNot AvailableEscherichia coli (strain K12)
URibonuclease pancreaticNot AvailableHumans
UPutative ATP-dependent Clp protease proteolytic subunit, mitochondrialNot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as methionine and derivatives. These are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Methionine and derivatives
Alternative Parents
N-acyl-L-alpha-amino acids / N-formyl-alpha amino acids / Thia fatty acids / Secondary carboxylic acid amides / Sulfenyl compounds / Monocarboxylic acids and derivatives / Dialkylthioethers / Carboxylic acids / Organopnictogen compounds / Organonitrogen compounds
show 3 more
Substituents
Aliphatic acyclic compound / Carbonyl group / Carboxamide group / Carboxylic acid / Dialkylthioether / Fatty acid / Fatty acyl / Hydrocarbon derivative / Methionine or derivatives / Monocarboxylic acid or derivatives
show 14 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
proteinogenic amino acid, L-methionine derivative, N-formyl amino acid (CHEBI:16552) / Other amino acids (C03145)
Affected organisms
Not Available

Chemical Identifiers

UNII
PS9357B4XH
CAS number
4289-98-9
InChI Key
PYUSHNKNPOHWEZ-YFKPBYRVSA-N
InChI
InChI=1S/C6H11NO3S/c1-11-3-2-5(6(9)10)7-4-8/h4-5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
IUPAC Name
(2S)-2-formamido-4-(methylsulfanyl)butanoic acid
SMILES
[H]C(=O)N[C@@H](CCSC)C(O)=O

References

General References
Not Available
KEGG Compound
C03145
PubChem Compound
439750
PubChem Substance
46505840
ChemSpider
388809
ChEBI
16552
ZINC
ZINC000001529464
PDBe Ligand
FME
Wikipedia
N-Formylmethionine
PDB Entries
1bq9 / 1dce / 1dxr / 1dza / 1ijd / 1kzu / 1lk6 / 1mhc / 1prc / 1q16 …
show 540 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility9.75 mg/mLALOGPS
logP-0.61ALOGPS
logP-0.16Chemaxon
logS-1.3ALOGPS
pKa (Strongest Acidic)3.93Chemaxon
pKa (Strongest Basic)-1.4Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area66.4 Ã…2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity42.54 m3·mol-1Chemaxon
Polarizability17.27 Ã…3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9413
Blood Brain Barrier+0.9176
Caco-2 permeable-0.6728
P-glycoprotein substrateNon-substrate0.5324
P-glycoprotein inhibitor INon-inhibitor0.9525
P-glycoprotein inhibitor IINon-inhibitor0.985
Renal organic cation transporterNon-inhibitor0.933
CYP450 2C9 substrateNon-substrate0.7296
CYP450 2D6 substrateNon-substrate0.787
CYP450 3A4 substrateNon-substrate0.6463
CYP450 1A2 substrateNon-inhibitor0.849
CYP450 2C9 inhibitorNon-inhibitor0.9239
CYP450 2D6 inhibitorNon-inhibitor0.9684
CYP450 2C19 inhibitorNon-inhibitor0.9381
CYP450 3A4 inhibitorNon-inhibitor0.9824
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9951
Ames testNon AMES toxic0.8335
CarcinogenicityNon-carcinogens0.9495
BiodegradationNot ready biodegradable0.6075
Rat acute toxicity1.2614 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9831
hERG inhibition (predictor II)Non-inhibitor0.973
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MS (2 TMS)GC-MSsplash10-0pdi-1920000000-7ead52d367d0c14c2f83
GC-MS Spectrum - GC-MS (1 TMS)GC-MSsplash10-002r-9800000000-d6bd1c4a45710fcff139
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-000y-9200000000-10205de54a16e96cf3ad
GC-MS Spectrum - EI-BGC-MSsplash10-004i-1900000000-dbd5e7526844833f2769
GC-MS Spectrum - EI-BGC-MSsplash10-002b-1931000000-f6d54f9e00989580bf16
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0zi1-0920000000-eff4a723ccd21264f857
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-002r-6900000000-f44202a7297064bce497
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0pdj-0920000000-4d46bd9a6a5f645fdee9
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-9410000000-0d6268555c7a6ebf60ef
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-004i-0900000000-a5b03aa018c68be71432
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-002b-9600000000-e2a1a85ea82026c67c40
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-9000000000-4f909deb0784221401df
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-9000000000-e07240ba0c7d6b253cf3
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-9000000000-04ba3fa1d5a4d4da730a
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-004i-4900000000-b9244ecfa5c3afeec4c8
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03fr-0900000000-6cef5cfd02af4e4f5603
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0fc0-2900000000-ca29f2380d125436464f
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0gx0-9600000000-d8211d4ecddfb71549d2
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0bu0-9200000000-95443fc05ab3a30f1736
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03di-9100000000-61580bdacfbf4ccd3b72
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-8900000000-a0baa1f0d498b5592629
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9300000000-c432965c9afa08362ac1
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-01q0-9200000000-c48c476fbace131de14c
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-dbd0c4175a10dd51e002
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-03di-9000000000-2574d90ed7ef35706690
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-e15405a266f15b1a65ab
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (â„«2)Source typeSource
[M-H]-138.4358638
predicted
DarkChem Lite v0.1.0
[M-H]-131.52379
predicted
DeepCCS 1.0 (2019)
[M+H]+138.9914638
predicted
DarkChem Lite v0.1.0
[M+H]+135.3538
predicted
DeepCCS 1.0 (2019)
[M+Na]+138.4916638
predicted
DarkChem Lite v0.1.0
[M+Na]+144.02219
predicted
DeepCCS 1.0 (2019)

Targets

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insights and accelerate drug research.
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Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A ...
Gene Name
RABGGTA
Uniprot ID
Q92696
Uniprot Name
Geranylgeranyl transferase type-2 subunit alpha
Molecular Weight
65071.06 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A ...
Gene Name
RABGGTB
Uniprot ID
P53611
Uniprot Name
Geranylgeranyl transferase type-2 subunit beta
Molecular Weight
36924.04 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Rhodopseudomonas viridis
Pharmacological action
Unknown
General Function
Iron ion binding
Specific Function
The reaction center of purple bacteria contains a tightly bound cytochrome molecule which re-reduces the photo oxidized primary electron donor.
Gene Name
pufC
Uniprot ID
P07173
Uniprot Name
Photosynthetic reaction center cytochrome c subunit
Molecular Weight
39370.915 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Rhodopseudomonas viridis
Pharmacological action
Unknown
General Function
Electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
Specific Function
The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
Gene Name
puhA
Uniprot ID
P06008
Uniprot Name
Reaction center protein H chain
Molecular Weight
28498.245 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Rhodopseudomonas viridis
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
Gene Name
pufL
Uniprot ID
P06009
Uniprot Name
Reaction center protein L chain
Molecular Weight
30578.225 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Rhodopseudomonas viridis
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
Gene Name
pufM
Uniprot ID
P06010
Uniprot Name
Reaction center protein M chain
Molecular Weight
36035.285 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Rhodopseudomonas acidophila
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
Gene Name
Not Available
Uniprot ID
P35089
Uniprot Name
Light-harvesting protein B-800/820 alpha chain
Molecular Weight
5545.65 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Rhodopseudomonas acidophila
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
Gene Name
Not Available
Uniprot ID
P35094
Uniprot Name
Light-harvesting protein B-800/820 beta chain
Molecular Weight
4725.425 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Rhodopseudomonas acidophila
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
Gene Name
Not Available
Uniprot ID
P26789
Uniprot Name
Light-harvesting protein B-800/850 alpha chain
Molecular Weight
5653.73 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Rhodopseudomonas acidophila
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
Gene Name
Not Available
Uniprot ID
P26790
Uniprot Name
Light-harvesting protein B-800/850 beta chain
Molecular Weight
4554.18 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Serine-type endopeptidase inhibitor activity
Specific Function
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory a...
Gene Name
SERPINC1
Uniprot ID
P01008
Uniprot Name
Antithrombin-III
Molecular Weight
52601.935 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Identical protein binding
Specific Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Gene Name
B2M
Uniprot ID
P61769
Uniprot Name
Beta-2-microglobulin
Molecular Weight
13714.43 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Nadh dehydrogenase (ubiquinone) activity
Specific Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the tra...
Gene Name
MT-ND1
Uniprot ID
P03886
Uniprot Name
NADH-ubiquinone oxidoreductase chain 1
Molecular Weight
35660.055 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Peptide antigen binding
Specific Function
Involved in the presentation of foreign antigens to the immune system.
Gene Name
HLA-B
Uniprot ID
P01889
Uniprot Name
HLA class I histocompatibility antigen, B-27 alpha chain
Molecular Weight
40427.835 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Nitrate reductase activity
Specific Function
The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The alpha chain is the actual site of nitrate reduction.
Gene Name
narG
Uniprot ID
P09152
Uniprot Name
Respiratory nitrate reductase 1 alpha chain
Molecular Weight
140488.49 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters invo...
Gene Name
narH
Uniprot ID
P11349
Uniprot Name
Respiratory nitrate reductase 1 beta chain
Molecular Weight
58065.915 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Nitrate reductase activity
Specific Function
The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, whi...
Gene Name
narI
Uniprot ID
P11350
Uniprot Name
Respiratory nitrate reductase 1 gamma chain
Molecular Weight
25497.16 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Vitamin d binding
Specific Function
Not Available
Gene Name
S100G
Uniprot ID
P29377
Uniprot Name
Protein S100-G
Molecular Weight
9016.14 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Pharmacological action
Unknown
General Function
Iron ion binding
Specific Function
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule....
Gene Name
rub
Uniprot ID
P00269
Uniprot Name
Rubredoxin
Molecular Weight
5574.145 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name
COX4I1
Uniprot ID
P13073
Uniprot Name
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Molecular Weight
19576.6 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Iron ion binding
Specific Function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic su...
Gene Name
MT-CO1
Uniprot ID
P00395
Uniprot Name
Cytochrome c oxidase subunit 1
Molecular Weight
57040.91 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the ...
Gene Name
MT-CO2
Uniprot ID
P00403
Uniprot Name
Cytochrome c oxidase subunit 2
Molecular Weight
25564.73 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
Subunits I, II and III form the functional core of the enzyme complex.
Gene Name
MT-CO3
Uniprot ID
P00414
Uniprot Name
Cytochrome c oxidase subunit 3
Molecular Weight
29950.6 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name
COX5A
Uniprot ID
P20674
Uniprot Name
Cytochrome c oxidase subunit 5A, mitochondrial
Molecular Weight
16761.985 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name
COX5B
Uniprot ID
P10606
Uniprot Name
Cytochrome c oxidase subunit 5B, mitochondrial
Molecular Weight
13695.57 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name
COX6C
Uniprot ID
P09669
Uniprot Name
Cytochrome c oxidase subunit 6C
Molecular Weight
8781.36 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) de...
Gene Name
COX7B
Uniprot ID
P24311
Uniprot Name
Cytochrome c oxidase subunit 7B, mitochondrial
Molecular Weight
9160.485 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name
COX7C
Uniprot ID
P15954
Uniprot Name
Cytochrome c oxidase subunit 7C, mitochondrial
Molecular Weight
7245.45 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name
COX8A
Uniprot ID
P10176
Uniprot Name
Cytochrome c oxidase subunit 8A, mitochondrial
Molecular Weight
7579.0 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name
COX6A2
Uniprot ID
Q02221
Uniprot Name
Cytochrome c oxidase subunit 6A2, mitochondrial
Molecular Weight
10815.32 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
Connects the two COX monomers into the physiological dimeric form.
Gene Name
COX6B1
Uniprot ID
P14854
Uniprot Name
Cytochrome c oxidase subunit 6B1
Molecular Weight
10192.345 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Cytochrome-c oxidase activity
Specific Function
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name
COX7A1
Uniprot ID
P24310
Uniprot Name
Cytochrome c oxidase subunit 7A1, mitochondrial
Molecular Weight
9117.44 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Methyltransferase activity
Specific Function
Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its...
Gene Name
fmt
Uniprot ID
P23882
Uniprot Name
Methionyl-tRNA formyltransferase
Molecular Weight
34168.16 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Streptomyces avidinii
Pharmacological action
Unknown
General Function
Not Available
Specific Function
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
Gene Name
Not Available
Uniprot ID
P22629
Uniprot Name
Streptavidin
Molecular Weight
18833.61 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the b...
Gene Name
S100B
Uniprot ID
P04271
Uniprot Name
Protein S100-B
Molecular Weight
10712.985 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Staphylococcus aureus
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Lyses erythrocytes and many other mammalian cells.
Gene Name
hld
Uniprot ID
P0C1V1
Uniprot Name
Delta-hemolysin
Molecular Weight
2978.515 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Protease binding
Specific Function
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubi...
Gene Name
UBC
Uniprot ID
P0CG48
Uniprot Name
Polyubiquitin-C
Molecular Weight
77038.08 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Arthrospira platensis HN01
Pharmacological action
Unknown
General Function
Hydrogen ion transmembrane transporter activity
Specific Function
Not Available
Gene Name
atpH
Uniprot ID
A5HEI4
Uniprot Name
AtpH
Molecular Weight
8180.505 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Manganese ion binding
Specific Function
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions. Also shows phosphodiesterase activity, hydrolyz...
Gene Name
ulaG
Uniprot ID
P39300
Uniprot Name
Probable L-ascorbate-6-phosphate lactonase UlaG
Molecular Weight
40060.435 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Streptococcus sp. group G
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
spg
Uniprot ID
P19909
Uniprot Name
Immunoglobulin G-binding protein G
Molecular Weight
63291.11 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
gshA
Uniprot ID
P0A6W9
Uniprot Name
Glutamate--cysteine ligase
Molecular Weight
58268.695 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Ribonuclease a activity
Specific Function
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
Gene Name
RNASE1
Uniprot ID
P07998
Uniprot Name
Ribonuclease pancreatic
Molecular Weight
17644.125 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Serine-type endopeptidase activity
Specific Function
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, ...
Gene Name
CLPP
Uniprot ID
Q16740
Uniprot Name
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Molecular Weight
30179.76 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]

Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52